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120, 219, 246], 'mutants': [19, 77, 94], 'differ': [20], 'considerably': [21, 118], 'including': [22, 201], 'copper-binding': [23, 80], 'abilities.': [24], 'Nevertheless,': [25], 'they': [26], 'cause': [27], 'the': [28, 66, 96, 107, 113, 129, 181, 189, 194, 202, 240], 'same': [29], 'disease': [30, 182, 195], 'phenotype,': [31], 'suggesting': [32], 'a': [33, 156, 173], 'common': [34, 88], 'neurotoxic': [35], 'pathway.': [36], 'We': [37, 221], 'previously': [39], 'reported': [40], 'that': [41, 84, 223, 226], 'copper': [42, 57, 85, 97, 101, 123, 159, 174, 231], 'homeostasis': [43], 'is': [44, 54, 59, 87], 'disturbed': [45], 'spinal': [47, 104, 130], 'cords': [48, 105], 'SOD1G93A': [50, 185], 'mice.': [51, 108], 'However,': [52], 'it': [53], 'unknown': [55], 'whether': [56], 'dyshomeostasis': [58, 86, 160], 'induced': [60], 'by': [61, 245], 'other': [62, 126], 'mutants.': [64, 91, 121], 'Using': [65], 'additional': [67], 'mouse': [68], 'strains': [69], 'SOD1G127insTGGG,': [70], 'SOD1G85R,': [71], 'and': [72, 151, 179, 207, 209], 'SOD1D90A,': [73], 'which': [74], 'express': [75], 'with': [78], 'different': [79], 'abilities,': [81], 'we': [82], 'show': [83], 'shifted': [95], 'trafficking': [98], 'systems': [99], 'toward': [100], 'accumulation': [102], 'Copper': [109], 'contents': [110], 'bound': [111, 124], 'active': [115], 'site': [116], 'varied': [117], 'between': [119], 'Still,': [122], 'ligands': [127], 'cord': [131], 'were': [132, 143], 'markedly': [133, 198], 'increased': [134], 'all.': [136], 'Zinc': [137], 'was': [138, 163, 191], 'also': [139], 'increased,': [140], 'whereas': [141], 'there': [142], 'no': [144], 'changes': [145], 'magnesium,': [147], 'calcium,': [148], 'aluminum,': [149], 'manganese': [150], 'iron.': [152], 'Further': [153], 'support': [154], 'for': [155, 239], 'role': [157], 'ALS': [162, 243], 'gained': [164], 'from': [165], 'results': [166], 'pharmacological': [168, 224], 'intervention.': [169], 'Ammonium': [170], 'tetrathiomolybdate': [171], '(TTM),': [172], 'chelating': [175], 'agent,': [176], 'prolonged': [177], 'survival': [178], 'slowed': [180], 'progression': [183], 'mice,': [186], 'even': [187], 'when': [188], 'treatment': [190, 241], 'started': [192], 'after': [193], 'onset.': [196], 'TTM': [197, 215], 'attenuated': [199], 'pathology,': [200], 'loss': [203], 'motor': [205], 'neurons': [206], 'axons,': [208], 'atrophy': [210], 'skeletal': [212], 'muscles.': [213], 'Additionally,': [214], 'decreased': [216], 'amounts': [217], 'aggregates.': [220], 'propose': [222], 'agents': [225], 'are': [227], 'capable': [228], 'modulating': [230], 'dyshomeostasis,': [232], 'such': [233], 'as': [234], 'TTM,': [235], 'might': [236], 'be': [237], 'beneficial': [238], 'caused': [244], 'mutations.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057097767', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-24T14:54:17.994796', 'created_date': '2016-06-24'}