Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2057016890', 'doi': 'https://doi.org/10.1021/ol000271e', 'title': 'Vinylogous Amide Analogues of Diaminopimelic Acid (DAP) as Inhibitors of Enzymes Involved in Bacterial Lysine Biosynthesis', 'display_name': 'Vinylogous Amide Analogues of Diaminopimelic Acid (DAP) as Inhibitors of Enzymes Involved in Bacterial Lysine Biosynthesis', 'publication_year': 2000, 'publication_date': '2000-11-01', 'ids': {'openalex': 'https://openalex.org/W2057016890', 'doi': 'https://doi.org/10.1021/ol000271e', 'mag': '2057016890', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11101437'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ol000271e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201989124', 'display_name': 'Organic Letters', 'issn_l': '1523-7052', 'issn': ['1523-7052', '1523-7060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055735574', 'display_name': 'Jennifer F. Caplan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}, {'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer F. Caplan', 'raw_affiliation_strings': ['Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I129975664', 'https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103396577', 'display_name': 'Renjian Zheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}, {'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Renjian Zheng', 'raw_affiliation_strings': ['Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I129975664', 'https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047974197', 'display_name': 'John S. Blanchard', 'orcid': 'https://orcid.org/0000-0002-9195-4402'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}, {'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'John S. Blanchard', 'raw_affiliation_strings': ['Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I129975664', 'https://openalex.org/I154425047']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007325812', 'display_name': 'John C. Vederas', 'orcid': 'https://orcid.org/0000-0002-2996-0326'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}, {'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'John C. Vederas', 'raw_affiliation_strings': ['Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I154425047', 'https://openalex.org/I129975664']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.084, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.819307, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '2', 'issue': '24', 'first_page': '3857', 'last_page': '3860'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Nucleotide Metabolism and Enzyme Regulation', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12441', 'display_name': 'Molecular Mechanisms of Heme Biosynthesis and Related Disorders', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/diaminopimelic-acid', 'display_name': 'Diaminopimelic acid', 'score': 0.75020266}, {'id': 'https://openalex.org/keywords/amide', 'display_name': 'Amide', 'score': 0.5637591}, {'id': 'https://openalex.org/keywords/transition-state-analogue-inhibitors', 'display_name': 'Transition State Analogue Inhibitors', 'score': 0.474019}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.83515203}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.7705792}, {'id': 'https://openalex.org/C2779425345', 'wikidata': 'https://www.wikidata.org/wiki/Q30126674', 'display_name': 'Diaminopimelic acid', 'level': 4, 'score': 0.75020266}, {'id': 'https://openalex.org/C2776016237', 'wikidata': 'https://www.wikidata.org/wiki/Q178430', 'display_name': 'Lysine', 'level': 3, 'score': 0.72606266}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.7119262}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.61870575}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.58925134}, {'id': 'https://openalex.org/C2778439535', 'wikidata': 'https://www.wikidata.org/wiki/Q188777', 'display_name': 'Amide', 'level': 2, 'score': 0.5637591}, {'id': 'https://openalex.org/C2777756961', 'wikidata': 'https://www.wikidata.org/wiki/Q620730', 'display_name': 'Glycine', 'level': 3, 'score': 0.4789096}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.3904652}, {'id': 'https://openalex.org/C2776634448', 'wikidata': 'https://www.wikidata.org/wiki/Q206920', 'display_name': 'Peptidoglycan', 'level': 3, 'score': 0.19126588}], 'mesh': [{'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D001419', 'descriptor_name': 'Bacteria', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D003960', 'descriptor_name': 'Diaminopimelic Acid', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D003960', 'descriptor_name': 'Diaminopimelic Acid', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D044925', 'descriptor_name': 'Oxidoreductases Acting on CH-CH Group Donors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000591', 'descriptor_name': 'Amino Acid Isomerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000591', 'descriptor_name': 'Amino Acid Isomerases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000594', 'descriptor_name': 'Amino Acid Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000594', 'descriptor_name': 'Amino Acid Oxidoreductases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001419', 'descriptor_name': 'Bacteria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001419', 'descriptor_name': 'Bacteria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003960', 'descriptor_name': 'Diaminopimelic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D003960', 'descriptor_name': 'Diaminopimelic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050746', 'descriptor_name': 'Dihydrodipicolinate Reductase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ol000271e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201989124', 'display_name': 'Organic Letters', 'issn_l': '1523-7052', 'issn': ['1523-7052', '1523-7060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11101437', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.57}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W1520607277', 'https://openalex.org/W1548124641', 'https://openalex.org/W1962497945', 'https://openalex.org/W2000974000', 'https://openalex.org/W2011771340', 'https://openalex.org/W2020244051', 'https://openalex.org/W2049163769', 'https://openalex.org/W2066997239', 'https://openalex.org/W2080702261', 'https://openalex.org/W2088908335'], 'related_works': ['https://openalex.org/W4232250374', 'https://openalex.org/W2334856061', 'https://openalex.org/W2319810038', 'https://openalex.org/W2148110240', 'https://openalex.org/W2059501078', 'https://openalex.org/W2028008798', 'https://openalex.org/W2022537905', 'https://openalex.org/W2015839901', 'https://openalex.org/W1984026504', 'https://openalex.org/W1964298537'], 'abstract_inverted_index': {'Vinylogous': [0], 'amides': [1], '5': [2, 41], 'and': [3, 11, 29], '6': [4], 'have': [5], 'been': [6], 'synthesized': [7], 'from': [8], 'l-propargyl': [9], 'glycine': [10], 'tested': [12], 'against': [13, 45], 'diaminopimelate': [14], '(DAP)': [15], 'enzymes': [16], 'involved': [17], 'in': [18, 35], 'bacterial': [19], 'lysine': [20], 'biosynthesis.': [21], 'Both': [22], 'are': [23], 'reversible': [24], 'inhibitors': [25], 'of': [26, 54, 73], 'DAP': [27, 30], 'd-dehydrogenase': [28], 'epimerase': [31], 'with': [32, 50], 'IC50': [33], 'values': [34], 'the': [36, 46, 61, 69, 74], '500': [37], 'μM': [38], 'range.': [39], 'Compound': [40], 'shows': [42], 'competitive': [43], 'inhibition': [44], 'l-dihydrodipicolinate': [47], '(DHDP)': [48], 'reductase': [49], 'a': [51], 'Ki': [52], 'value': [53], '32': [55], 'μM,': [56], 'which': [57], 'is': [58], 'comparable': [59], 'to': [60], 'planar': [62], 'dipicolinate': [63], '16': [64], '(Ki': [65], '=': [66], '26': [67], 'μM),': [68], 'best': [70], 'known': [71], 'inhibitor': [72], 'enzyme.': [75]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057016890', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-15T07:23:35.321847', 'created_date': '2016-06-24'}