Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2057002012', 'doi': 'https://doi.org/10.1021/np960165e', 'title': 'Anti-HIV Triterpene Acids from <i>Geum japonicum</i>', 'display_name': 'Anti-HIV Triterpene Acids from <i>Geum japonicum</i>', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W2057002012', 'doi': 'https://doi.org/10.1021/np960165e', 'mag': '2057002012', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8759159'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/np960165e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166799026', 'display_name': 'Journal of Natural Products', 'issn_l': '0163-3864', 'issn': ['0163-3864', '1520-6025'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034735808', 'display_name': 'Hong‐Xi Xu', 'orcid': 'https://orcid.org/0000-0001-6238-4511'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Hong-Xi Xu', 'raw_affiliation_strings': ['Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore'], 'affiliations': [{'raw_affiliation_string': 'Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019639042', 'display_name': 'Fa‐Quan Zeng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Fa-Quan Zeng', 'raw_affiliation_strings': ['Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore'], 'affiliations': [{'raw_affiliation_string': 'Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083120615', 'display_name': 'Min Wan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Min Wan', 'raw_affiliation_strings': ['Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore'], 'affiliations': [{'raw_affiliation_string': 'Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085685167', 'display_name': 'Keng‐Yeow Sim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Keng-Yeow Sim', 'raw_affiliation_strings': ['Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore'], 'affiliations': [{'raw_affiliation_string': 'Departments of Chemistry and Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.28, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 207, 'citation_normalized_percentile': {'value': 0.930796, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '59', 'issue': '7', 'first_page': '643', 'last_page': '645'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11889', 'display_name': 'Molecular Mechanisms and Medical Applications of Ginseng', 'score': 0.9739, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13221', 'display_name': 'Biological Activity of Diterpenoids and Biflavonoids', 'score': 0.9552, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ursolic-acid', 'display_name': 'Ursolic acid', 'score': 0.94212663}, {'id': 'https://openalex.org/keywords/anti-inflammatory-properties', 'display_name': 'Anti-inflammatory Properties', 'score': 0.42496}], 'concepts': [{'id': 'https://openalex.org/C2780527577', 'wikidata': 'https://www.wikidata.org/wiki/Q2915788', 'display_name': 'Triterpene', 'level': 3, 'score': 0.9649848}, {'id': 'https://openalex.org/C2779513101', 'wikidata': 'https://www.wikidata.org/wiki/Q416260', 'display_name': 'Ursolic acid', 'level': 2, 'score': 0.94212663}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5839019}, {'id': 'https://openalex.org/C2777583353', 'wikidata': 'https://www.wikidata.org/wiki/Q410261', 'display_name': 'HIV-1 protease', 'level': 4, 'score': 0.53307086}, {'id': 'https://openalex.org/C160492267', 'wikidata': 'https://www.wikidata.org/wiki/Q319616', 'display_name': 'Pharmacognosy', 'level': 4, 'score': 0.4846097}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.47901672}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.44239748}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40641353}, {'id': 'https://openalex.org/C116073593', 'wikidata': 'https://www.wikidata.org/wiki/Q864491', 'display_name': 'Biological activity', 'level': 3, 'score': 0.34141502}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33321226}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.25814897}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2279641}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.19432989}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017320', 'descriptor_name': 'HIV Protease Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014315', 'descriptor_name': 'Triterpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D017320', 'descriptor_name': 'HIV Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017320', 'descriptor_name': 'HIV Protease Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014315', 'descriptor_name': 'Triterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014315', 'descriptor_name': 'Triterpenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/np960165e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166799026', 'display_name': 'Journal of Natural Products', 'issn_l': '0163-3864', 'issn': ['0163-3864', '1520-6025'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8759159', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1981416132', 'https://openalex.org/W1993115150', 'https://openalex.org/W2007317838', 'https://openalex.org/W2017786352', 'https://openalex.org/W2025330536', 'https://openalex.org/W2032416673', 'https://openalex.org/W2038671526', 'https://openalex.org/W2043474268', 'https://openalex.org/W2043870086', 'https://openalex.org/W2081795703', 'https://openalex.org/W2119508100', 'https://openalex.org/W2322678346', 'https://openalex.org/W2330663019'], 'related_works': ['https://openalex.org/W349314872', 'https://openalex.org/W3049342150', 'https://openalex.org/W2808375843', 'https://openalex.org/W2386871319', 'https://openalex.org/W2362600930', 'https://openalex.org/W2361824795', 'https://openalex.org/W2358453218', 'https://openalex.org/W2184970650', 'https://openalex.org/W2057002012', 'https://openalex.org/W2026763161'], 'abstract_inverted_index': {'The': [0, 49], 'methanol': [1], 'extract': [2], 'from': [3], 'the': [4, 14, 24, 52], 'whole': [5], 'plant': [6], 'of': [7, 23, 51], 'Geum': [8], 'japonicum': [9], 'was': [10, 55], 'found': [11], 'to': [12, 68], 'inhibit': [13], 'human': [15], 'immunodeficiency': [16], 'virus': [17], '(HIV-1)': [18], 'protease.': [19, 88], 'Through': [20], 'bioassay-directed': [21], 'fractionation': [22], 'extract,': [25], 'a': [26], 'new': [27, 53], 'triterpene': [28, 34], 'acid': [29, 71, 81], 'along': [30], 'with': [31], 'five': [32], 'known': [33], 'acids,': [35], 'ursolic': [36, 77], 'acid,': [37, 39, 41, 43, 46, 78], 'epipomolic': [38], 'maslinic': [40, 80], 'euscaphic': [42], 'and': [44, 65, 79], 'tormentic': [45], 'were': [47], 'isolated.': [48], 'structure': [50], 'compound': [54], 'determined': [56], 'by': [57], 'spectral': [58], 'means': [59], 'including': [60], '1H−1H': [61], 'COSY,': [62], 'HMQC,': [63], 'HMBC,': [64], 'NOE': [66], 'experiments': [67], 'be': [69], '2α,19α-dihydroxy-3-oxo-12-ursen-28-oic': [70], '(1).': [72], 'Of': [73], 'these': [74], 'compounds,': [75], '1,': [76], 'showed': [82], 'potent': [83], 'inhibitory': [84], 'activity': [85], 'against': [86], 'HIV-1': [87]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2057002012', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-13T01:55:01.224684', 'created_date': '2016-06-24'}