Title: Structural principles of the globular organization of protein chains. A stereochemical theory of globular protein secondary structure
Abstract: The paper reveals the types of amino acid sequences of polypeptide chain regions of globular protein which form a regular (α or β) or irregular conformation in the native globule. The study was made taking into account general “architectural” principles of packing of polypeptide chains in globular proteins and considering the interactions of proteins with water molecules. An a priori theory is developed which permits the identification, in good agreement with experiment, of α-helical and β-structural regions in globular proteins from their primary structure.
Publication Year: 1974
Publication Date: 1974-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 352
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