Publication Information

{'id': 'https://openalex.org/W2056671431', 'doi': 'https://doi.org/10.1074/jbc.m204455200', 'title': 'A Role for Protein Phosphatase-2A in p38 Mitogen-activated Protein Kinase-mediated Regulation of the c-Jun NH2-terminal Kinase Pathway in Human Neutrophils', 'display_name': 'A Role for Protein Phosphatase-2A in p38 Mitogen-activated Protein Kinase-mediated Regulation of the c-Jun NH2-terminal Kinase Pathway in Human Neutrophils', 'publication_year': 2002, 'publication_date': '2002-10-01', 'ids': {'openalex': 'https://openalex.org/W2056671431', 'doi': 'https://doi.org/10.1074/jbc.m204455200', 'mag': '2056671431', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12186863'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m204455200', 'pdf_url': 'http://www.jbc.org/article/S0021925819721747/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819721747/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113628269', 'display_name': 'Natalie J. 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3700, 4277], 'the': [9, 41, 102, 109, 149, 169, 180, 186, 230, 235, 254, 286, 347, 354, 394, 414, 425, 431, 475, 480, 503, 633, 644, 772, 816, 823, 840, 879, 888, 895, 924, 931, 964, 1039, 1066, 1081, 1099, 1118, 1121, 1137, 1197, 1224, 1229, 1233, 1244, 1334, 1353, 1367, 1382, 1436, 1478, 1501, 1507, 1516, 1549, 1565, 1568, 1575, 1580, 1590, 1594, 1611, 1624, 2261, 2328, 2365, 2468, 2536, 2602, 2621, 2630, 2693, 2703, 2750, 2824, 2907, 2933, 2970, 2973, 2981, 2990, 2996, 3001, 3013, 3214, 3269, 3286, 3317, 3344, 3416, 3457, 3577, 3585, 3593, 3606, 3613, 3658, 3839, 3990, 4017, 4036, 4042, 4050, 4073, 4086, 4098, 4154, 4171, 4197, 4205, 4221, 4229, 4238, 4278, 4281, 4309, 4329, 4332, 4355, 4365, 4385, 4392], 'effective': [10, 255], 'control': [11, 256], 'of': [12, 17, 30, 35, 44, 55, 101, 115, 128, 171, 176, 214, 239, 257, 262, 275, 280, 289, 300, 346, 360, 373, 416, 421, 459, 484, 492, 505, 632, 643, 771, 775, 787, 835, 842, 882, 890, 897, 916, 947, 971, 1041, 1068, 1094, 1115, 1125, 1139, 1158, 1168, 1338, 1358, 1439, 1477, 1509, 1515, 1532, 1545, 1551, 1555, 1564, 1567, 1578, 1596, 1608, 1613, 1912, 2004, 2136, 2141, 2148, 2187, 2193, 2197, 2203, 2256, 2460, 2623, 2632, 2698, 2705, 2752, 2823, 2910, 2923, 2956, 2983, 2986, 3000, 3012, 3016, 3150, 3185, 3246, 3299, 3316, 3340, 3389, 3474, 3502, 3533, 3536, 3568, 3595, 3608, 3662, 3711, 3719, 3728, 3735, 3759, 3766, 3777, 3789, 3795, 3977, 3982, 3994, 4009, 4044, 4058, 4064, 4072, 4089, 4094, 4100, 4111, 4116, 4153, 4173, 4192, 4204, 4210, 4218, 4231, 4240, 4280, 4331, 4345, 4352, 4357, 4396, 4399], 'microbial': [13, 258], 'infections.': [14, 259], 'Although': [15, 260, 3254, 3786], 'exposure': [16, 141, 184, 261, 386, 429, 3374, 3473], 'neutrophils': [18, 67, 263, 312, 766, 1087, 1483, 2722, 2760, 2869, 2881, 2920, 3151, 3174, 3365, 3393, 3464, 3475, 3496, 3632, 3808, 3986, 4010, 4346, 4370, 4400], 'to': [19, 33, 62, 105, 142, 185, 206, 264, 278, 307, 350, 387, 430, 451, 495, 650, 745, 939, 963, 1333, 1366, 1571, 1904, 2041, 2047, 2180, 2235, 2318, 2327, 2364, 2453, 2467, 2605, 2608, 2689, 2833, 2890, 2980, 3213, 3336, 3353, 3375, 3385, 3476, 3481, 3497, 3715, 3792, 4033, 4080, 4129, 4182, 4187, 4377], 'cytokines': [20, 265, 664], 'such': [21, 242, 266, 487, 665, 1089, 1143, 2624, 2673, 3199, 3208], 'as': [22, 243, 267, 488, 666, 832, 1065, 1603, 1629, 1858, 1880, 1921, 2273, 2488, 2495, 2614, 2674, 2835, 3200, 3209, 4252], 'tumor': [23, 268, 526, 582], 'necrosis': [24, 269, 527, 583], 'factor-α': [25, 270], '(TNFα),': [26, 271], 'generated': [27, 272], 'at': [28, 273, 1206, 1968, 2019, 2169, 2214, 2225, 2433, 2440, 2446, 2481, 2627, 3022, 3491, 3592, 4041], 'sites': [29, 274], 'inflammation,': [31, 276], 'leads': [32, 277], 'activation': [34, 54, 279, 299, 504, 774, 889, 1494, 2719, 2816, 3192, 3229, 3249, 3260, 3272, 3279, 3302, 3361, 3388, 3552, 4088, 4110, 4195, 4217, 4319, 4351, 4409], 'MAPK': [36, 46, 107, 117, 178, 281, 291, 352, 362, 423, 508, 827, 926, 949, 1043, 1078, 1095, 1198, 1201, 1225, 1475, 1493, 1547, 1582, 2754, 2774, 2925, 3306, 3329, 3342, 3391, 3587, 3610, 3750, 3979, 4069, 4084, 4194, 4213, 4313], 'pathways,': [37, 282, 622, 892, 2613], 'mechanisms': [38, 283, 813], 'responsible': [39, 284], 'fine': [42, 287], 'regulation': [43, 100, 288, 345, 1067, 1093, 1476, 1566], 'specific': [45, 290, 843, 1177, 2633, 3140], 'modules': [47, 292], 'remain': [48, 293, 819], 'unknown.': [49, 294], 'We': [50, 295, 1074, 1504, 3324, 3619, 4184], 'have': [51, 296, 767, 1135, 1429, 1505, 2713, 2837, 3382, 3620, 3798, 3832], 'previously': [52, 297, 1630, 1859, 1882, 1922, 2497, 2838, 3383, 3622, 3799], 'demonstrated': [53, 298, 1136, 2912, 2952, 3564, 3731], 'a': [56, 143, 164, 172, 226, 301, 388, 409, 417, 471, 783, 914, 1090, 1165, 1359, 1375, 1469, 1496, 1540, 1844, 2181, 2188, 2313, 2343, 2351, 2557, 2766, 2891, 2902, 3134, 3182, 3313, 3348, 3377, 3477, 3500, 3556, 3756, 3787, 4004, 4112, 4244, 4324, 4381], 'TNFα-mediated': [57, 302], 'JNK': [58, 103, 130, 151, 181, 196, 231, 303, 348, 375, 396, 426, 441, 476, 645, 817, 932, 956, 987, 1083, 1479, 1502, 1518, 1533, 1556, 1837, 1955, 2064, 2097, 2373, 2405, 2718, 2757, 2815, 2828, 2877, 2911, 2914, 2937, 2951, 2957, 2976, 2987, 3004, 3158, 3171, 3191, 3227, 3248, 3259, 3271, 3278, 3287, 3301, 3322, 3351, 3360, 3420, 3459, 3589, 3596, 3601, 3840, 4074, 4113, 4131, 4224, 4317, 4342, 4353, 4386, 4407], 'pathway': [59, 104, 304, 349, 646, 818, 927, 1071, 1084, 1480, 1534, 3228, 3288, 3319, 3602, 3722, 3841, 4038, 4075, 4318], 'module,': [60, 305], 'leading': [61, 306], 'apoptosis': [63, 154, 308, 399, 790, 2564], 'adherent': [65, 310, 764], 'human': [66, 311, 765, 1086, 1482, 1676, 2603, 2721, 2759, 3807], '(Avdi,': [68, 313], 'N.': [69, 314, 3915], 'J.,': [70, 315, 4292], 'Nick,': [71, 316], 'J.': [72, 91, 317, 336, 717, 805, 1000, 1010, 1025, 1214, 1264, 1409, 1644, 1759, 1871, 1897, 1938, 2081, 2390, 2512, 2589, 2645, 2741, 2786, 2794, 2854, 3068, 3101, 3129, 3408, 3439, 3647, 3823, 3851, 3939, 4163, 4259, 4265, 4298], 'A.,': [73, 79, 318, 324], 'Whitlock,': [74, 319], 'B.': [75, 320, 847, 1415, 1749, 3058, 4257], 'B.,': [76, 321, 3847], 'Billstrom,': [77, 322], 'M.': [78, 323, 669, 673, 675, 726, 734, 1258, 1399, 1637, 1757, 2641, 2659, 2776, 2780, 3066, 3110, 3125, 3855, 3870], 'Henson,': [80, 325], 'P.': [81, 326, 677, 707, 1866, 2643, 2655, 2661, 2784, 2800, 3112, 3114, 3127, 3403, 3434, 3882, 3890, 4158], 'M.,': [82, 327], 'Johnson,': [83, 328, 1850], 'G.': [84, 88, 329, 333], 'L.,': [85, 330], 'and': [86, 108, 121, 131, 192, 209, 237, 331, 353, 366, 376, 437, 454, 482, 627, 640, 652, 662, 741, 750, 758, 782, 933, 953, 957, 968, 973, 1017, 1047, 1104, 1123, 1161, 1170, 1181, 1200, 1240, 1243, 1303, 1307, 1312, 1406, 1522, 1524, 1553, 1574, 1619, 1669, 1704, 1796, 1830, 1835, 1856, 1915, 1958, 1996, 2033, 2039, 2100, 2121, 2145, 2163, 2200, 2209, 2233, 2237, 2244, 2266, 2276, 2303, 2316, 2321, 2399, 2408, 2457, 2519, 2528, 2554, 2563, 2574, 2695, 2772, 2813, 2861, 2918, 3010, 3137, 3203, 3234, 3240, 3252, 3505, 3549, 3588, 3617, 3626, 3660, 3666, 3669, 3699, 3830, 3992, 3997, 4070, 4118, 4120, 4132, 4149, 4220, 4225, 4288, 4337, 4394], 'Worthen,': [87, 332], 'S.': [89, 334, 698, 1262, 1423, 1761, 3070, 3861, 3898, 3921, 3936, 3949], '(2001)': [90, 335], 'Biol.': [92, 337, 806, 1011, 1152, 1252, 1276, 1288, 1645, 1898, 1939, 2082, 2391, 2513, 2590, 2742, 2855, 3648, 3824, 3940, 4164, 4303], 'Chem.276,': [93, 338], '2189–2199).': [94, 339], 'Herein,': [95, 340, 1464], 'evidence': [96, 341, 875, 922, 4276], 'presented': [98, 343], 'linking': [99, 344], 'p38': [106, 116, 160, 177, 223, 351, 361, 405, 422, 468, 625, 884, 925, 948, 1042, 1077, 1162, 1474, 1492, 1510, 1546, 1581, 1597, 1960, 2753, 2924, 2991, 3141, 3222, 3281, 3305, 3311, 3318, 3328, 3341, 3368, 3390, 3478, 3487, 3507, 3530, 3562, 3569, 3578, 3586, 3609, 3689, 3749, 3978, 4037, 4068, 4083, 4175, 4193, 4212, 4242, 4312], 'Ser/Thr': [110, 187, 355, 432, 1207, 1241, 2358, 2411, 2425], 'protein': [111, 356, 515, 530, 534, 539, 546, 571, 586, 590, 595, 602, 657, 1108, 2058, 2958, 2988, 3205, 3737, 3779, 4283], 'phosphatase-2A': [112, 357], '(PP2A).': [113, 358], 'Inhibition': [114, 359], 'by': [118, 363, 502, 900, 1072, 1223, 2037, 2053, 2231, 2242, 3007, 3196, 3204, 3231, 3291, 3372, 3448, 3461, 3547, 3769, 4254], 'SB': [119, 364, 1702, 1705, 2675, 2764, 2872, 2883, 3008, 3017, 3180, 3186, 3238, 3664, 3695, 3706, 3712, 3995, 4012], '203580': [120, 365, 2873, 2884, 3009, 3018, 3239, 3665, 3696, 4013], 'M': [122, 367, 1710, 3143, 3153, 3241, 3265, 3667, 3701, 4374], '39': [123, 368, 1711, 3154, 3242, 3266, 3702, 4375], 'resulted': [124, 216, 369, 461, 3243, 3331, 4404], 'significant': [126, 371], 'augmentation': [127, 372, 3245, 3298, 3718, 3758, 4383], 'TNFα-induced': [129, 150, 153, 374, 395, 398, 773, 1082, 2756, 2814, 3003, 3157, 3170, 3359, 3458, 3720, 3760, 4018, 4316, 4341, 4366], 'MKK4': [132, 215, 377, 460, 1552, 2130, 2177, 3616, 3625, 3670, 3675, 3680, 3721, 3736, 3983, 4124, 4219, 4232, 4248], '(but': [133, 378], 'not': [134, 379, 2691, 3189, 3542, 3704, 3745, 3753, 3784, 4015, 4048, 4180, 4363], 'MKK7': [135, 380, 3627, 3761, 3778], 'or': [136, 381, 1063, 2051, 3312, 3598, 4201], 'MEKK1)': [137, 382, 1523], 'activation,': [138, 383, 959], 'whereas': [139, 384, 1195], 'prior': [140, 385, 3373, 3480, 4376], 'p38-activating': [144, 389], 'agent': [145, 390], '(platelet-activating': [146, 391], 'factor)': [147, 392], 'diminished': [148, 393], 'response.': [152, 397, 4367], 'was': [155, 204, 400, 449, 1678, 1685, 1693, 1713, 1776, 1786, 1811, 1822, 1851, 2012, 2044, 2057, 2178, 2324, 2348, 2397, 2428, 2451, 2464, 2486, 2565, 2817, 2829, 2864, 2886, 2930, 2978, 3145, 3188, 3362, 3446, 3488, 3544, 3553, 3672, 3682, 3691, 4000, 4078, 4103, 4250, 4388], 'also': [156, 401, 1097, 1525, 1918, 2702, 2887, 3267], 'greatly': [157, 402, 1036, 3683, 4108], 'enhanced': [158, 403, 3002, 3268, 3334, 4109, 4406], 'upon': [159, 404, 3472], 'inhibition.': [161, 406], 'Studies': [162, 407], 'with': [163, 408, 637, 1381, 1659, 1909, 2025, 2060, 2096, 2102, 2128, 2220, 2271, 2281, 2404, 2410, 2522, 2556, 2763, 2871, 2901, 2932, 2946, 3152, 3161, 3179, 3237, 3264, 3524, 4011, 4022, 4347, 4373, 4401], 'reconstituted': [165, 410, 4199], 'cell-free': [166, 411, 1972, 2206, 4061], 'system': [167, 412, 4062, 4200], 'indicated': [168, 413, 3538], 'absence': [170, 415, 3659, 3991, 4356, 4395], 'direct': [173, 418], 'inhibitory': [174, 419, 1498, 4190], 'effect': [175, 420, 1499, 1508, 2751], 'on': [179, 424, 763, 769, 1500, 1512, 1526, 2629, 2708, 2755, 3019, 3612, 3984, 4196, 4202, 4323, 4340], 'module.': [182, 427], 'Neutrophil': [183, 428], 'phosphatase': [188, 199, 433, 444, 1140, 1336, 2248, 2282, 2322, 4284], 'inhibitors': [189, 434, 1598, 2635, 2672, 3207, 4334], 'okadaic': [190, 435, 954, 4338, 4402], 'acid': [191, 436, 1692, 4339, 4403], 'calyculin': [193, 438, 4335, 4348, 4378], 'A': [194, 439, 1372, 3251, 4060, 4336, 4349, 4379], 'induced': [195, 440, 899, 3006, 3195, 3230, 4350], 'activation.': [197, 442, 1535, 1557, 4343], 'Increased': [198, 443, 2876], 'activity': [200, 445, 988, 1337, 2323, 2485, 2863, 2878, 2938, 2977, 3508, 3671, 3681, 3690, 3723, 3762, 3999, 4020, 4290], 'following': [201, 446, 2882, 2921, 3280, 3304], 'TNFα': [202, 447, 667, 1677, 2272, 2523, 2716, 4358], 'stimulation': [203, 448], 'shown': [205, 450, 2714, 3384, 3621, 3800, 3833], 'be': [207, 452, 1128, 2619, 2687, 3194, 3470, 4031, 4056], 'PP2A-associated': [208, 453], 'p38-dependent.': [210, 455], 'Furthermore,': [211, 456, 1536], 'PP2A-induced': [212, 457], 'dephosphorylation': [213, 458, 1550, 2103, 2137, 2142], 'its': [218, 463, 4122, 4321], 'inactivation.': [219, 464], 'Thus,': [220, 465, 3276], 'neutrophils,': [222, 467, 2370, 3262], 'MAPK,': [224, 469, 513, 569, 626, 885, 4176, 4243], 'through': [225, 470, 2312], 'PP2A-mediated': [227, 472], 'mechanism,': [228, 473], 'regulates': [229, 474, 929], 'pathway,': [232, 477, 789], 'thus': [233, 478, 893, 3575, 4135], 'determining': [234, 479], 'extent': [236, 481, 1122, 2893], 'nature': [238, 483], 'subsequent': [240, 485], 'responses': [241, 486, 491, 845], 'apoptosis.': [244, 489], 'The': [490, 1309, 1349, 2091, 2172, 2252, 2336, 3297, 4208], 'eukaryotic': [493, 917], 'cells': [494, 995, 1021, 1339, 2617, 3164, 4024], 'external': [496], 'stimuli': [497, 1573], 'are': [498, 1174, 1204, 3628], 'regulated': [499], 'part': [501], 'three': [506, 3292], 'major': [507, 1296], '1The': [509, 565], 'abbreviations': [510, 566], 'used': [511, 567, 1622, 3146], 'are:': [512, 568], 'mitogen-activated': [514, 533, 538, 545, 570, 589, 594, 601], 'kinase;': [516, 520, 524, 536, 543, 551, 572, 576, 580, 592, 599, 607], 'ERK,': [517, 573, 624, 1159], 'extracellular': [518, 574], 'signal-regulated': [519, 541, 548, 575, 597, 604], 'JNK,': [521, 577, 628, 776, 1160, 2199, 3543], 'c-Jun': [522, 578, 2005, 4133, 4226], 'NH2-terminal': [523, 579], 'TNFα,': [525, 581, 1910, 2834, 3337], 'factor-α;': [528, 584], 'PP,': [529, 585], 'phosphatase;': [531, 587], 'MKK,': [532, 588], 'kinase': [535, 542, 549, 550, 557, 591, 598, 605, 606, 613, 1202, 2189, 2612, 3515, 4006], 'MEK,': [537, 593], 'kinase/extracellular': [540, 547, 596, 603], 'MEKK,': [544, 600, 1828], 'GST,': [552, 608], 'glutathione': [553, 609], 'S-transferase;': [554, 610], 'SEK,': [555, 611], 'SAPK/ERK': [556, 612], '(SEK1);': [558, 614], 'MOPS,': [559, 615], '4-morpholinepropanesulfonic': [560, 616], 'acid;': [561, 617], 'PAF,': [562, 618, 3376], 'platelet-activating': [563, 619], 'factor.': [564, 620], 'signaling': [621, 780, 836, 935, 1070], 'p42/44': [623], 'which': [629, 1173, 1227, 1236, 1293, 1473, 2043, 2347, 2677, 2929, 3367, 3688], 'mediate': [630], 'many': [631, 746], 'cellular': [634, 748, 1116, 1454], 'processes': [635, 1146], 'associated': [636], 'growth,': [638], 'survival,': [639, 754], 'death.': [641], 'Activation': [642, 1157], 'occurs': [647, 3284, 3591], 'response': [649, 786, 938, 966, 1570, 2832, 3005, 3335, 3352, 3460, 4387], 'environmental': [651], 'physiological': [653], 'stresses,': [654], 'including': [655, 752, 2572, 4067], 'genotoxins,': [656], 'synthesis': [658, 970, 3206], 'inhibitors,': [659], 'oxidative': [660], 'agents,': [661], 'pro-inflammatory': [663, 1572, 3215], '(1Buscher': [668], 'Rahmsdorf': [670], 'H.J.': [671], 'Litfin': [672], 'Karin': [674, 733, 3854], 'Herrlich': [676], 'Oncogene.': [678, 981, 3115], '1988;': [679], '3:': [680, 3970], '301-311Google': [681], 'Scholar,': [682, 703, 724, 866, 1256, 1268, 1280, 2649, 2790, 3082, 3106, 3119, 3866, 3903, 3926, 3945, 3958], '2Sherman': [683], 'M.L.': [684], 'Datta': [685], 'R.': [686, 1004, 2782, 2798, 3874], 'Hallahan': [687], 'D.E.': [688, 855], 'Weichselbaum': [689], 'R.R.': [690], 'Kufe': [691], 'D.W.': [692], 'Proc.': [693, 1418, 3856, 3893, 3916], 'Natl.': [694, 1419, 3857, 3894, 3917], 'Acad.': [695, 1420, 3858, 3895, 3918], 'Sci.': [696, 1190, 1344, 1421, 3859, 3896, 3919], 'U.': [697, 1422, 3860, 3897, 3920], 'A.': [699, 728, 732, 978, 1260, 1411, 1424, 1735, 2778, 2792, 3044, 3862, 3899, 3922], '1990;': [700, 1327], '87:': [701], '5663-5666Google': [702], '3Kyriakis': [704], 'J.M.': [705], 'Banerjee': [706], 'Nikolakaki': [708], 'E.': [709, 1185, 1413, 1457, 3849, 3878], 'Dai': [710], 'T.': [711, 730, 1391, 3868, 3905, 3907, 3928, 3947, 3964, 4296], 'Rubie': [712], 'E.A.': [713, 1763, 3072], 'Ahmad': [714], 'M.F.': [715], 'Avruch': [716], 'Woodgett': [718], 'J.R.': [719], 'Nature.': [720], '1994;': [721, 1215], '369:': [722], '156-160Google': [723], '4Hibi': [725], 'Lin': [727, 1758, 3067], 'Smeal': [729], 'Minden': [731], 'Genes': [735, 907, 1400], 'Dev.': [736, 862, 908], '1993;': [737], '7:': [738], '2135-2148Google': [739], 'Scholar),': [740, 1194, 1292, 1650, 2396, 2812, 3133, 3829], 'has': [742, 1495, 1586, 1599], 'been': [743, 1601, 2960, 3177, 3370, 3739, 3781], 'linked': [744], 'important': [747, 1529, 1587], 'functions': [749], 'processes,': [751], 'cell': [753, 2277, 2570], 'death,': [755], 'gene': [756], 'expression,': [757], 'embryogenesis.': [759], 'Our': [760, 1045], 'previous': [761, 4137], 'studies': [762, 1134, 1385, 1467, 4138], 'focused': [768], 'characterization': [770], 'defining': [777], 'both': [778, 930, 951, 1196, 1238, 1511, 2770, 3624, 3663, 3693, 4390], 'upstream': [779, 3600, 3794, 3981, 4057], 'components': [781, 4148], 'downstream': [784, 1544, 3314, 4206], 'functional': [785, 1530, 2696], 'this': [788, 1126, 1446, 2862, 3492, 3551], '(26Avdi': [791, 1883, 1924, 2067, 2376, 2498, 2727, 2840, 3633, 3809], 'N.J.': [792, 1633, 1717, 1864, 1884, 1925, 2068, 2377, 2499, 2728, 2841, 3026, 3090, 3397, 3428, 3634, 3810], 'Nick': [793, 1885, 1926, 2069, 2378, 2500, 2579, 2729, 2842, 3635, 3811], 'J.A.': [794, 1862, 1886, 1927, 2070, 2379, 2501, 2580, 2730, 2843, 3084, 3395, 3426, 3636, 3812], 'Whitlock': [795, 1887, 1928, 2071, 2380, 2502, 2731, 2844, 3637, 3813], 'B.B.': [796, 1888, 1929, 2072, 2381, 2503, 2732, 2845, 3638, 3814], 'Billstrom': [797, 1889, 1930, 2073, 2382, 2504, 2733, 2846, 3639, 3815], 'M.A.': [798, 1890, 1931, 2074, 2383, 2505, 2734, 2847, 3640, 3816], 'Henson': [799, 1891, 1932, 2075, 2384, 2506, 2587, 2735, 2848, 3097, 3641, 3817, 3889], 'P.M.': [800, 1892, 1933, 2076, 2385, 2507, 2588, 2736, 2849, 3098, 3642, 3818], 'Johnson': [801, 1640, 1867, 1893, 1934, 2077, 2386, 2508, 2737, 2850, 3404, 3435, 3643, 3819, 3891, 3912, 3937, 3952, 3965, 4161], 'G.L.': [802, 1641, 1868, 1894, 1935, 2078, 2387, 2509, 2738, 2851, 3405, 3436, 3644, 3820, 3892, 3913, 3938, 3953, 3966, 4162], 'Worthen': [803, 1642, 1869, 1895, 1936, 2079, 2388, 2510, 2585, 2739, 2852, 3099, 3406, 3437, 3645, 3821], 'G.S.': [804, 1643, 1870, 1896, 1937, 2080, 2389, 2511, 2586, 2740, 2853, 3100, 3407, 3438, 3646, 3822], 'Chem.': [807, 1012, 1646, 1769, 1899, 1940, 2083, 2392, 2514, 2591, 2743, 2856, 3078, 3649, 3825, 3941, 4165], '2001;': [808, 1057, 1289, 1460, 1900, 1941, 2084, 2393, 2515, 2744, 2857, 3650, 3826, 4304], '276:': [809, 1901, 1942, 2085, 2394, 2516, 2745, 2858, 3651, 3827], '2189-2199Google': [810, 1902, 1943, 2086, 2395, 2517, 2746, 2859, 3652, 3828], 'Scholar).': [811, 873, 912, 985, 1156, 1218, 1348, 1463, 1773, 1876, 1944, 2595, 2669, 2747, 3414, 3653, 3972, 4169, 4274], 'However,': [812, 1092, 4368], 'that': [814, 838, 878, 923, 1076, 1120, 1491, 2541, 2715, 2768, 2953, 2972, 3175, 3309, 3326, 3380, 3486, 3539, 3550, 3565, 3623, 3732, 3774, 3801, 3834, 4035, 4052, 4140, 4311], 'regulate': [815, 839, 1080, 3321, 4315], 'poorly': [820], 'defined.': [821], 'In': [822, 913, 942, 3168, 3747, 4091, 4170, 4235], 'yeast': [824, 880, 1387], 'Saccharomyces': [825], 'cerevisiae,': [826], 'pathways': [828, 936, 1096, 3590], 'were': [829, 1621, 1651, 1671, 1707, 1800, 1838, 1878, 1917, 1963, 2023, 2031, 2035, 2093, 2126, 2218, 2229, 2240, 2250, 2269, 2279, 2308, 2402, 2438, 2479, 2493, 2533, 2545, 2549, 2761, 3522, 3570, 3655, 3987, 4185, 4371], 'initially': [830], 'conceptualized': [831], 'linear': [833], 'hierarchies': [834], 'molecules': [837], 'expression': [841], 'phenotypic': [844], '(5Errede': [846], 'Cade': [848], 'R.M.': [849], 'Yashar': [850], 'B.M.': [851], 'Kamada': [852], 'Y.': [853, 3843, 3880, 3886], 'Levin': [854], 'Irie': [856], 'K.': [857, 859, 1389, 1393, 1743, 3052, 3884], 'Matsumoto': [858], 'Mol.': [860, 4301], 'Reprod.': [861], '1995;': [863, 870, 1191, 2809, 4271], '42:': [864, 1771, 3080], '477-485Google': [865], '6Herskowitz': [867], 'I.': [868, 906], 'Cell.': [869, 1055, 1458, 4302], '80:': [871], '187-197Google': [872], 'Recent': [874, 1133, 4275], 'suggests,': [876], 'however,': [877], 'homolog': [881], 'mammalian': [883], 'Hog1,': [886], 'limits': [887], 'other': [891, 2709, 3020, 4053], 'altering': [894], 'repertoire': [896], 'MAPKs': [898, 1163], 'osmotic': [901], 'stress': [902], "(7O'Rourke": [903], 'S.M.': [904, 1148, 1248, 1729, 3038], 'Herskowitz': [905], '1998;': [909, 1013, 1425, 2592, 3955, 3969], '12:': [910, 1154, 1254], '2874-2886Google': [911], 'variety': [915, 3788], 'cells,': [918, 1913, 2680], 'there': [919], 'mounting': [921], 'negatively': [928], 'ERK': [934, 958, 3424], 'diverse': [940], 'stimuli.': [941, 3296], 'papilloma-producing': [943], 'mouse': [944], 'keratinocytes,': [945], 'inhibition': [946, 2922, 3223, 3307, 3330, 3611, 3751, 3976], 'augments': [950], 'native': [952], 'acid-induced': [955], 'increases': [960], 'AP-1': [961], 'binding': [962], '12-O-tetradecanoylphorbol-13-acetate': [965], 'element,': [967], 'enhances': [969], 'JunD': [972], 'FosB': [974], '(8Rosenberger': [975], 'S.F.': [976], 'Gupta': [977], 'Bowden': [979], 'G.T.': [980], '1999;': [982, 1770, 2664, 3079, 3116, 3923, 3942], '18:': [983, 3117], '3626-3632Google': [984], 'Similarly,': [986], 'osmotically': [990], 'stressed': [991], 'Madin-Darby': [992], 'canine': [993], 'kidney': [994], '(9Sheikh-Hamad': [996], 'D.,': [997], 'Di': [998], 'Mari': [999], 'Suki': [1001], 'W.N.': [1002], 'Safirstein': [1003], 'Watts': [1005], 'III,': [1006], 'B.A.': [1007], 'Rouse': [1008, 2793], 'D.': [1009, 3876], '273:': [1014, 2593], '1832-1837Google': [1015], 'Scholar)': [1016, 1034, 1060, 1330, 1405, 1428, 1903, 2087, 2518, 3445, 4307], '1,25-dihydroxyvitamin-differentiated': [1019], 'HL-60': [1020], '(10Wang': [1022], 'X.': [1023], 'Rao': [1024], 'Studzinski': [1026], 'G.P.': [1027], 'Exp.': [1028], 'Cell': [1029, 1151, 1251, 1275, 1287, 1813], 'Res.': [1030], '2000;': [1031, 1153, 1253, 1265, 2646, 3103, 3130, 3863, 3900], '258:': [1032], '425-437Google': [1033], 'increased': [1037, 2913, 3156, 3277], 'presence': [1040, 2982, 3661, 3993, 4099, 4172, 4239, 4393], 'inhibitors.': [1044], 'group': [1046], 'others': [1048, 3831, 4255], '(11Dumont': [1049], 'J.E.': [1050], 'Pecasse': [1051], 'F.': [1052], 'Maenhaut': [1053], 'C.': [1054, 3401, 3432, 3872], 'Signal.': [1056, 1459], '13:': [1058, 1216, 1290, 1461], '457-463Google': [1059], 'define': [1061], 'cross-talk': [1062], 'cross-signaling': [1064], 'one': [1069], 'another.': [1073], 'hypothesized': [1075, 3325], 'may': [1079, 2686, 3320, 4039, 4055, 4314], 'via': [1088, 1486, 4320], 'mechanism.': [1091], 'involves': [1098, 1164], 'dynamic': [1100], 'interplay': [1101], 'between': [1102, 2611, 3584], 'kinases': [1103, 1199, 1203, 2707, 3021, 3615, 3790], 'phosphatases.': [1105], 'Because': [1106, 2596], 'kinase-mediated': [1107], 'phosphorylation': [1109, 1167, 2238, 2822, 2915, 3159, 3172, 4093, 4230, 4249, 4408], 'utilized': [1111, 2688], 'every': [1113, 1453], 'aspect': [1114], 'function,': [1117], 'requirement': [1119, 1444], 'amplitude': [1124], 'action': [1127, 4322], 'tightly': [1129], 'controlled': [1130], 'essential.': [1132], 'importance': [1138], 'participation': [1141], 'regulatory': [1145, 1369, 1378], '(12Keyse': [1147, 1247], 'Curr.': [1149, 1249, 1273, 1285], 'Opin.': [1150, 1250, 1274, 1286], '186-192Google': [1155, 1255], 'reversible/dual': [1166], 'Tyr': [1169, 1239], 'Thr': [1171], 'residues,': [1172], 'located': [1175], 'motifs,': [1178], 'TEY,': [1179], 'TPY,': [1180], 'TGY,': [1182], 'respectively': [1183], '(13Cano': [1184], 'Mahadevan': [1186], 'L.C.': [1187], 'Trends': [1188, 1342], 'Biochem.': [1189, 1343, 2644, 3128], '20:': [1192], '117-122Google': [1193], 'phosphorylated': [1205, 3529], 'residues': [1208], '(14Zheng': [1209], 'C.F.': [1210, 1721, 1753, 3030, 3062], 'Guan': [1211], 'K.L.': [1212], 'EMBO': [1213, 2785], '1123-1131Google': [1217], 'Conversely,': [1219], 'inactivation': [1220], 'facilitated': [1222], 'phosphatases,': [1226, 1235], 'include': [1228], 'single-specificity': [1230], 'tyrosine': [1231], 'phosphatases;': [1232], 'dual-specificity': [1234], 'dephosphorylate': [1237], 'residues;': [1242], 'serine/threonine': [1245, 1335], 'phosphatases': [1246], '15Camps': [1257], 'Nichols': [1259], 'Arkinstall': [1261], 'FASEB': [1263], '14:': [1266], '6-16Google': [1267], '16Neel': [1269], 'B.G.': [1270, 1284], 'Tonks': [1271], 'N.K.': [1272, 1282], '1997;': [1277, 1345, 2787, 3411, 3442, 4166], '9:': [1278], '193-204Google': [1279], '17Tonks': [1281], 'Neel': [1283], '182-195Google': [1291], 'comprise': [1294], 'four': [1295], 'classes:': [1297], 'PP1,': [1298], 'PP2A': [1299, 1315, 1350, 1543, 1775, 2056, 2368, 4285], '(including': [1300], 'PP4,': [1301], 'PP5,': [1302], 'PP7),': [1304], 'PP2B': [1305], '(calcineurin),': [1306], 'PP2C.': [1308], 'highly': [1310, 3139], 'conserved': [1311], 'extremely': [1313], 'abundant': [1314], 'family': [1316], '(18Cohen': [1317], 'P.T.': [1318, 1341], 'Brewis': [1319], 'N.D.': [1320], 'Hughes': [1321], 'V.': [1322], 'Mann': [1323], 'D.J.': [1324], 'FEBS': [1325, 2662, 2807], 'Lett.': [1326, 2663, 2808], '268:': [1328], '355-359Google': [1329], 'contributes': [1331], 'extensively': [1332], '(19Cohen': [1340], '22:': [1346], '245-251Google': [1347], 'holoenzyme': [1351], 'comprises': [1352], 'core': [1354], 'enzyme': [1355, 1447], '(PP2AD),': [1356], 'consisting': [1357, 4115], '36-kDa': [1360], 'catalytic': [1361, 1437], 'subunit': [1362, 1371, 1379, 1438], '(PP2Ac)': [1363], 'strongly': [1364], 'bound': [1365], '65-kDa': [1368], 'scaffold-like': [1370], '(PR65),': [1373], 'while': [1374], 'third': [1376], 'B': [1377], 'associates': [1380], 'core.': [1383], 'Knockout': [1384], '(20Kinoshita': [1388], 'Nemoto': [1390], 'Nabeshima': [1392], 'Kondoh': [1394], 'H.': [1395, 1397, 2639, 3123], 'Niwa': [1396], 'Yanagida': [1398], 'Cells.': [1401], '1996;': [1402, 1647, 1873], '1:': [1403], '29-45Google': [1404], 'mice': [1407], '(21Gotz': [1408], 'Probst': [1410], 'Ehler': [1412], 'Hemmings': [1414], 'Kues': [1416], 'W.': [1417], '95:': [1426], '12370-12375Google': [1427], 'reported': [1430, 2839, 3014, 4253], 'embryonic': [1431], 'lethality': [1432], 'genes': [1434], 'encoding': [1435], 'PP2A,': [1440], 'demonstrating': [1441], 'an': [1442, 1528, 1604, 2015, 2454, 2724, 2947, 3333, 3512, 3525, 3599, 3708], 'absolute': [1443], '(which': [1448], 'involved': [1450, 2254, 2339, 3837], 'almost': [1452], 'process)': [1455], '(22Sontag': [1456], '7-16Google': [1462], 'we': [1465, 2712, 2836, 3219, 3381, 3494, 3604, 3797, 4327], 'present': [1466, 2628, 3571], 'detailing': [1468], 'novel': [1470], 'mechanism': [1471], 'mediated': [1485], 'PP2A.': [1487, 2267], 'These': [1488], 'results': [1489, 4150], 'demonstrate': [1490], 'profound': [1497], 'pathway.': [1503, 1583], 'defined': [1506], 'each': [1513], 'member': [1514], 'putative': [1517], 'module': [1519, 4076, 4114], '(JNK,': [1520], 'MKK4/7,': [1521, 3796], 'apoptosis,': [1527], 'consequence': [1531], 'our': [1537, 1562], 'data': [1538], 'support': [1539], 'role': [1541], 'attenuation': [1554], 'Together,': [1558], 'these': [1559, 2615, 2706, 2943, 3534, 3729, 3767, 4177], 'findings': [1560], 'advance': [1561], 'understanding': [1563], 'potential': [1576], 'effects': [1577, 2704, 3015, 3607, 4191, 4330], 'inhibiting': [1579], 'This': [1584, 3467, 4028], 'study': [1585, 2749], 'implications': [1588], 'clinical': [1591], 'setting': [1592], 'where': [1593], 'use': [1595, 2631], 'already': [1600], 'proposed': [1602], 'adjunct': [1605], 'treatment': [1607], 'patients': [1609], 'resolution': [1612], 'certain': [1614, 2682], 'responses.': [1616], 'Endotoxin-free': [1617], 'reagents': [1618], 'plasticware': [1620], 'throughout': [1623], 'experimental': [1625], 'process.': [1626], 'Neutrophils,': [1627], 'prepared': [1628], 'described': [1631, 1860, 1881, 1923, 2274, 2496], '(23Avdi': [1632], 'Winston': [1634], 'B.W.': [1635], 'Russel': [1636], 'Young': [1638, 2803, 3085, 3398, 3429], 'S.K.': [1639, 3086, 3399, 3430], '271:': [1648], '33598-33606Google': [1649], 'resuspended': [1652], 'Krebs-Ringer': [1654], 'phosphate': [1655, 2340], 'buffer': [1656, 1974, 2066, 2099, 2105, 2144, 2150, 2224, 2284, 2375, 2407, 2413, 2427], '(pH': [1657, 1979, 2119, 2155, 2289], '7.2)': [1658], '0.2%': [1660], 'dextrose.': [1661], 'Aprotinin,': [1662], 'leupeptin,': [1663, 2302], 'phenylmethylsulfonyl': [1664], 'fluoride,': [1665], 'sodium': [1666, 1991], 'orthovanadate,p-nitrophenyl': [1667], 'phosphate,': [1668], 'anisomycin': [1670, 3255], 'purchased': [1672, 1679, 1787, 1801], 'from': [1673, 1680, 1686, 1694, 1708, 1714, 1777, 1802, 1812, 1823, 1839, 1846, 2342, 2369, 2567, 2819, 3519, 3677], 'Sigma.': [1674], 'Recombinant': [1675], 'Pharmingen.': [1681], 'serum': [1683, 2113], 'albumin': [1684], 'Intergen': [1687], 'Co.': [1688], '(Purchase,': [1689], 'NY).': [1690], 'Okadaic': [1691], 'Alexis': [1695], 'Biochemicals': [1696], '(San': [1697], 'Diego,': [1698], 'CA).': [1699, 1808], 'Calyculin': [1700], 'A,': [1701], '203580,': [1703, 2676, 2765, 3187, 3713, 3996], '202474': [1706], 'Calbiochem.': [1709], '((S)-5-[2-(1-phenylethylamino)pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-2-(4-piperidinyl)imidazole)': [1712], 'Merck': [1715], '(24Liverton': [1716, 3025], 'Butcher': [1718, 3027], 'J.W.': [1719, 3028], 'Claiborne': [1720, 3029], 'Claremon': [1722, 3031], 'D.A.': [1723, 3032], 'Libby': [1724, 3033], 'B.E.': [1725, 3034], 'Nguyen': [1726, 3035], 'K.T.': [1727, 3036], 'Pitzenberger': [1728, 3037], 'Selnick': [1730, 3039], 'H.G.': [1731, 3040], 'Smith': [1732, 3041], 'G.R.': [1733, 3042, 3853, 3888, 3930, 3951, 3962], 'Tebben': [1734, 3043], 'Vacca': [1736, 3045], 'J.P.': [1737, 3046], 'Varga': [1738, 3047], 'S.L.': [1739, 3048], 'Agarwal': [1740, 3049], 'L.': [1741, 1849, 3050], 'Dancheck': [1742, 3051], 'Forsyth': [1744, 3053], 'A.J.': [1745, 3054], 'Fletcher': [1746, 3055], 'D.S.': [1747, 3056], 'Frantz': [1748, 3057], 'Hanlon': [1750, 3059], 'W.A.': [1751, 3060], 'Harper': [1752, 3061], 'Hofsess': [1754, 3063], 'S.J.': [1755, 1765, 3064, 3074], 'Kostura': [1756, 3065], 'Luell': [1760, 3069], "O'Neill": [1762, 3071], "O'Keefe": [1764, 3073], 'et': [1766, 3075], 'al.J.': [1767, 3076], 'Med.': [1768, 3077], '2180-2190Google': [1772, 3081], 'Purified': [1774, 2055], 'Upstate': [1778, 1824, 1840], 'Biotechnology,': [1779, 1825, 1841, 2356], 'Inc.': [1780, 1826, 1842], '(Lake': [1781], 'Placid,': [1782], 'New': [1783], 'York).': [1784], '[γ-32P]ATP': [1785], 'fromAmersham': [1788], 'Biosciences.': [1789], 'Anti-JNK': [1790], '(C-17),': [1791], 'anti-MEKK1': [1792], '(C-22),': [1793], 'anti-MKK7': [1794], '(T-19),': [1795], 'anti-MKK4': [1797], '(K-18)': [1798], 'antibodies': [1799], 'Santa': [1803], 'Cruz': [1804], 'Biotechnology': [1805], '(Santa': [1806], 'Cruz,': [1807], 'Anti-phospho-JNK': [1809], 'antibody': [1810, 1819, 2062, 2904, 2948, 3526], 'Signaling': [1814], 'Technology': [1815], '(Beverly,': [1816], 'MA).': [1817], 'Anti-PP2A': [1818], '(clone': [1820], '1D6)': [1821], 'Active': [1827, 1945, 4105], 'unactive': [1829, 1949], 'active': [1831, 1833, 1959, 2129, 2908, 3490, 4174, 4211, 4241], 'GST-MKK4/SEK1,': [1832], 'p38,': [1834, 3540], 'wild-type': [1836, 1954, 2198], 'c-Jun,': [1843, 2194], 'gift': [1845], 'Dr.': [1847], 'Gary': [1848], 'expressed': [1852], 'Escherichia': [1854], 'coli': [1855], 'purified': [1857], '(25Nick': [1861], 'Avdi': [1863, 3089, 3396, 3427], 'Gerwins': [1865, 3402, 3433], 'Immunol.': [1872, 3102], '156:': [1874], '4867-4875Google': [1875], 'Neutrophils': [1877, 2268, 2492, 2548, 3654], 'preincubated': [1879], 'promote': [1905], 'adherence-like': [1906], 'conditions.': [1907], 'Stimulation': [1908], 'lysis': [1911, 2065, 2098, 2283, 2374, 2406], 'immunoprecipitation,': [1914], 'assays': [1916, 2249], 'carried': [1919], 'out': [1920, 2969], 'MEKK1': [1946, 3802, 3835, 3998, 4019, 4107], '(50': [1947, 2414], 'ng),': [1948, 1953], 'GST-wild-type': [1950], 'MKK4/SEK1': [1951], '(250': [1952, 2345], '(1': [1956], 'μg),': [1957], '(25': [1961, 2174], 'ng)': [1962, 2132], 'incubated': [1964, 2127, 2210, 2494, 2534], '10': [1966, 2146], 'min': [1967, 2018, 2213, 2432, 2473, 3454, 3504], '30': [1969, 2017, 2020, 2134, 2170, 2215, 2434, 2474], '°C': [1970], 'assay': [1973, 2104, 2143, 2207, 2412, 2426, 2455], 'containing': [1975, 2106, 2151, 2176, 2184, 2285], '20': [1976, 1997, 2115], 'mm': [1977, 1982, 1987, 1990, 1994, 1998, 2108, 2116, 2153, 2158, 2161, 2287, 2296, 2415], 'MOPS': [1978], '7.2),': [1980], '75': [1981], 'MgCl2,': [1983], '25': [1984, 2212, 2449], 'mmβ-glycerophosphate,': [1985], '5': [1986, 2300, 2304, 2431, 3453, 3503], 'EGTA,': [1988, 2297], '1': [1989, 1993, 2110, 2167, 2195, 2927, 2940, 2966, 3166], 'vanadate,': [1992], 'dithiothreitol,': [1995], 'ATP.': [1999], 'Following': [2000], 'this,': [2001, 3358], '500': [2002], 'ng': [2003, 2192], '15': [2007, 2160, 2201, 2444, 2472], 'μCi': [2008, 2202], '[32P]ATP': [2009, 2204], '(3000': [2010], 'Ci/ml)': [2011], 'added': [2013, 2429, 2465], 'additional': [2016], '°C.': [2021, 2171, 2216, 2435, 2475], 'Reactions': [2022, 2217], 'terminated': [2024, 2219, 2546], '5×': [2026, 2221], 'Laemmli': [2027, 2222], 'sample': [2028, 2223], 'buffer;': [2029], 'samples': [2030, 3730, 3768], 'boiled;': [2032], 'proteins': [2034, 2228, 4096], 'separated': [2036, 2230], 'SDS-PAGE': [2038, 2232], 'transferred': [2040, 2179, 2234, 2452], 'nitrocellulose,': [2042], 'either': [2045, 3310], 'exposed': [2046, 3495], 'film': [2048], 'autoradiography': [2050, 2243], 'analyzed': [2052], 'phosphorimaging.': [2054, 2245], 'A-Sepharose-immunoprecipitated': [2059], 'anti-PP2A': [2061], '2': [2089, 3274], 'h.': [2090], 'beads': [2092, 2125, 2401], 'washed': [2094, 2403], 'once': [2095, 4233], 'twice': [2101], '0.1': [2107, 2157, 2295], 'EDTA,': [2109, 2159], 'mg/ml': [2111], 'bovine': [2112], 'albumin,': [2114], 'imidazole': [2117], 'HCl': [2118], '7.63),': [2120], '0.1%': [2122, 2293, 2298], 'β-mercaptoethanol.': [2123], 'PP2A-bound': [2124, 2400], '(150': [2131], 'μl': [2135, 2140, 2147, 2186, 2450, 2459], 'mixture': [2138, 2190], '(20': [2139], 'solution': [2149], '50': [2152, 2286], 'Tris-HCl': [2154], '7.0),': [2156], 'caffeine,': [2162], '1%': [2164], 'β-mercaptoethanol)': [2165], 'h': [2168, 2530], 'supernatant': [2173], 'μl)': [2175], 'clean': [2182], 'tube': [2183, 2543], '35': [2185], '(500': [2191], 'μg': [2196], 'buffer)': [2208], '100': [2226, 2419, 2458], '°C;': [2227], 'nitrocellulose;': [2236], 'changes': [2239, 2568], 'visualized': [2241], 'Two': [2246], 'different': [2247, 3294], 'employed.': [2251], 'first': [2253], 'release': [2255, 2341], '32Pifrom': [2257], '32P-labeled': [2258, 4101], 'phosphorylase': [2259], 'a,': [2260], 'preferred': [2262], 'substrate': [2263], 'PP1': [2265], 'stimulated': [2270, 2521], 'above,': [2275], 'pellets': [2278], 'lysed': [2280, 2371], 'Tris': [2288], '7.14),': [2290], '10%': [2291], 'glycerol,': [2292], 'IGEPAL,': [2294], 'β-mercaptoethanol,': [2299], 'μg/ml': [2301, 2305], 'aprotinin.': [2306], 'Lysates': [2307], 'passed': [2309], 'five': [2310], 'times': [2311], '20-gauge': [2314], 'needle': [2315], 'subjected': [2317], 'swift': [2319], 'freeze-thawing,': [2320], 'determined': [2325, 2487, 2818, 3506, 3673, 4001], 'according': [2326, 2363, 2466], "manufacturer's": [2329, 2366, 2469], 'instructions': [2330, 2470], '(Protein': [2331], 'Phosphatase': [2332, 2359, 2484], 'Assay': [2333, 2360], 'Systems,': [2334], 'Invitrogen).': [2335], 'second': [2337], 'method': [2338], 'phosphopeptide': [2344], 'μm),': [2346], 'quantified': [2349], 'using': [2350, 3511], 'malachite': [2352, 2461], 'green': [2353, 2462], 'reagent': [2354, 2463], '(Upstate': [2355], 'Inc.,': [2357], 'Kit': [2361], 'I)': [2362], 'instructions.': [2367], 'immunoprecipitated,': [2398], 'then': [2409, 2520, 3338], 'Tris-HCl,': [2416], 'pH': [2417], '7.0,': [2418], 'nm': [2420], 'CaCl2).': [2421], '250': [2422], 'μmphosphopeptide': [2423], 'Microcentrifuge': [2436], 'tubes': [2437, 2532], 'centrifuged': [2439], '5000': [2441], 'rpm': [2442], 's': [2445], 'room': [2447], 'temperature;': [2448], 'plate;': [2456], 'Changes': [2476], 'absorbance': [2478], 'measured': [2480], '630': [2482], 'nm.': [2483], 'percent': [2489], 'unstimulated': [2490, 2880, 2917], 'control.': [2491], '1.0,': [2525], '1.5,': [2526], '2.0,': [2527], '2.5': [2529], '(all': [2531], 'same': [2537, 2944], 'time': [2538], 'period': [2539, 3501, 3558], 'so': [2540], 'all': [2542, 2963, 3573, 3742, 4147], 'reactions': [2544], 'together).': [2547], 'cytocentrifuged': [2550], 'onto': [2551], 'glass': [2552], 'slides': [2553], 'stained': [2555], 'Hema': [2558], '3': [2559, 3560], 'staining': [2560], 'kit': [2561], '(Fisher),': [2562], 'assessed': [2566], 'morphology,': [2571], 'nuclear': [2573], 'cytoplasmic': [2575], 'condensation': [2576], '(27Frasch': [2577], 'S.C.': [2578], 'Fadok': [2581], 'V.A.': [2582], 'Bratton': [2583], 'D.L.': [2584], '8389-8397Google': [2594], 'it': [2597], 'particularly': [2599], 'difficult': [2600], 'gain': [2606], 'access': [2607], 'interacting': [2609], 'points': [2610], 'primary': [2616], 'cannot': [2618], 'transfected,': [2620], 'delineation': [2622], 'events': [2625], 'relies': [2626], 'pharmacological': [2634], '(32Davies': [2636], 'S.P.': [2637, 3121, 4294], 'Reddy': [2638, 3122], 'Caivano': [2640, 3124], 'Cohen': [2642, 2660, 2783, 2799, 3113, 3126], '351:': [2647, 3131], '95-105Google': [2648, 3132], '42Eyers': [2650], 'P.A.': [2651], 'van': [2652], 'den': [2653], 'Ijssel': [2654], 'Quinlan': [2656], 'R.A.': [2657], 'Goedert': [2658, 3109], '451': [2665], '(.': [2666], 'P.):': [2667], '191-196IGoogle': [2668], 'Small': [2670], 'cell-permeant': [2671], 'readily': [2678], 'enters': [2679], 'provide': [2681], 'advantages': [2683], 'because': [2684, 3011], 'they': [2685], 'determine': [2690, 3581, 3974, 4081], 'only': [2692, 3256, 4126], 'roles': [2694], 'consequences': [2697], 'endogenous': [2699], 'kinases,': [2700], 'but': [2701, 2889, 3541, 4046, 4361], 'pathways.': [2710], 'Previously,': [2711], 'induces': [2717, 3258], 'adherence-dependent': [2725], 'manner': [2726], 'To': [2748, 2994, 3355, 3484, 3580, 3973], 'signaling,': [2758], 'pretreated': [2762, 2870, 3178, 3656, 3988, 4372], 'pyridinylimidazole': [2767], 'inhibits': [2769], 'p38αn': [2771], 'p38β2': [2773], '(28Goedert': [2775], 'Cuenda': [2777], 'Craxton': [2779], 'Jakes': [2781], '16:': [2788], '3563-3571Google': [2789], '29Cuenda': [2791], 'Doza': [2795], 'Y.N.': [2796], 'Meier': [2797], 'Gallagher': [2801], 'T.F.': [2802], 'P.R.': [2804], 'Lee': [2805], 'J.C.': [2806], '364:': [2810], '229-233Google': [2811], 'vitro': [2821, 3514, 4092, 4142], 'transcription': [2825], 'factor': [2826], 'c-Jun.': [2827], 'activated': [2830, 3290, 3371, 3447, 3546, 3629, 3804], 'Scholar);': [2860], 'significantly': [2865, 3455], 'augmented': [2866, 3684], 'TNFα-stimulated': [2868, 2896, 2919, 3300, 3631, 3678, 3806], '(Fig.1': [2874], 'A).': [2875, 2941, 3466, 3725], 'pretreatment': [2885, 3263, 3283, 3451], 'observed,': [2888], 'lesser': [2892], 'than': [2894], 'neutrophils.': [2897, 3679], 'Western': [2898, 3726, 3770], 'blots': [2899, 3727], 'probed': [2900, 3523], 'phospho-specific': [2903], 'directed': [2905, 2949, 3527], 'against': [2906, 2950, 3528], 'form': [2909], '(Fig.': [2926, 2939, 2965, 3165, 3273, 3559, 4025], 'B),': [2928, 2967], 'consistent': [2931], 'observed': [2934, 3303, 4389], 'increase': [2935, 2974, 4246], 'Reprobing': [2942], 'immunoblots': [2945, 3518, 3563], 'equal': [2954, 3566, 3733, 3775], 'amounts': [2955, 2985, 3567, 3734, 3776], 'had': [2959, 3176, 3369, 3738, 3780, 4125], 'immunoprecipitated': [2961, 3740, 3782], 'under': [2962, 3572, 3685, 3741], 'conditions': [2964, 3686, 3743], 'ruling': [2968], 'possibility': [2971, 4051, 4310], 'due': [2979], 'greater': [2984], 'inhibitor-pretreated': [2992], 'samples.': [2993], 'validate': [2995], 'vivo': [2998], 'specificity': [2999], 'higher': [3023], 'concentrations': [3024], '30Nick': [3083], 'Brown': [3087], 'K.K.': [3088], 'Arndt': [3091], 'P.G.': [3092], 'Suratt': [3093], 'B.T.': [3094], 'Janes': [3095], 'M.S.': [3096], '164:': [3104], '2151-2159Google': [3105], '31Hall-Jackson': [3107], 'C.A.': [3108], 'Hedge': [3111], '2047-2054Google': [3118], '32Davies': [3120], 'structurally': [3135], 'distinct': [3136], 'more': [3138], 'inhibitor,': [3142], '39,': [3144, 3668], 'parallel.': [3148], 'Pretreatment': [3149, 3236, 4008, 4344, 4398], 'similarly': [3155, 3225], 'compared': [3160, 4021], 'non-M': [3162], '39-pretreated': [3163], 'B).': [3167, 3253, 3275, 3561, 3764], 'contrast,': [3169, 3748], '202474,': [3181, 3707], 'non-active': [3183], 'analog': [3184, 3710], 'augmented.': [3190], 'can': [3193], 'DNA-damaging': [3197], 'agents': [3198], 'UV': [3201, 3232], 'irradiation': [3202, 3233], 'anisomycin,': [3210], 'addition': [3212], 'cytokine': [3216], 'TNFα.': [3217, 3354, 4397], 'Therefore,': [3218, 4326], 'questioned': [3220], 'whether': [3221, 3582, 3975, 4082], 'would': [3224], 'augment': [3226, 4364], 'anisomycin.': [3235], 'UV-induced': [3247], '(Fig.2,': [3250], 'weakly': [3257], 'anisomycin-induced': [3270], 'inhibitor': [3282, 3479], 'when': [3285], 'mechanistically': [3293], 'suggests': [3308], 'effector': [3315], 'activity.': [3323, 3579], 'if': [3327, 4369], 'pre-activation': [3339], 'should': [3346], 'cause': [3347], 'concomitant': [3349], 'decreased': [3350, 3456], 'further': [3356, 4382], 'investigate': [3357], 'studied': [3363, 3605], 'lipid': [3378], 'mediator': [3379], 'induce': [3386, 3716], 'rapid': [3387], '(33Nick': [3394, 3425], 'Knall': [3400, 3431], 'Clin.': [3409, 3440], 'Invest.': [3410, 3441], '99:': [3412, 3443], '975-986Google': [3413, 3444], 'Under': [3415], 'given': [3417], 'conditions,': [3418, 3574], 'neither': [3419, 4214], '(Fig.3': [3421, 3465], 'B)': [3422], 'nor': [3423, 4227], 'PAF.': [3449], 'PAF': [3450, 3482, 3498, 3548], '47%': [3462], 'reduction': [3468], 'could': [3469, 4030], 'reversed': [3471], 'stimulation.': [3483], 'verify': [3485], 'indeed': [3489], 'time,': [3493], 'over': [3499, 3555], 'immunoprecipitates': [3510, 3676], 'assay.': [3516, 4007], 'Additionally,': [3517], 'PAF-stimulated': [3520], 'lysates': [3521], 'MAPKs.': [3531], 'Both': [3532], 'methods': [3535], 'assessment': [3537], 'rapidly': [3545], 'sustained': [3554], '5-min': [3557], 'normalizing': [3576], 'interaction': [3583], 'level': [3594, 4043], 'itself': [3597], 'member,': [3603], 'JNK-activating': [3614], 'MKK7.': [3618], 'inhibited,': [3692], '(Fig.4': [3697, 3724, 3763], 'A)': [3698], '(data': [3703, 3744, 3783], 'shown).': [3705, 3746, 3785], 'inactive': [3709], 'failed': [3714], 'any': [3717, 4189, 4203], 'did': [3752, 4014, 4179, 4362], 'result': [3754], 'similar': [3757], 'Analysis': [3765], 'blotting': [3771], 'again': [3772], 'confirmed': [3773], 'appear': [3791, 4181], 'lie': [3793], '(34Xia': [3842], 'Makris': [3844], 'C.,': [3845], 'Su,': [3846], 'Li,': [3848, 4293], 'Yang': [3850], 'Nemerow': [3852], '97:': [3864, 3901], '5243-5248Google': [3865], '35Yujiri': [3867], 'Ware': [3869], 'Widmann': [3871], 'Oyer': [3873], 'Russell': [3875], 'Chan': [3877, 3910], 'Zaitsu': [3879], 'Clarke': [3881], 'Tyler': [3883], 'Oka': [3885], 'Fanger': [3887, 3929, 3950, 3961], '7272-7277Google': [3902], '36Minamino': [3904], 'Yujiri': [3906, 3963], 'Papst': [3908], 'P.J.': [3909], 'E.D.': [3911], 'Terada': [3914], '96:': [3924], '15127-15132Google': [3925], '37Yujiri': [3927], 'Garrington': [3931], 'T.P.': [3932], 'Schlesinger': [3933], 'T.K.': [3934, 3960], 'Gibson': [3935], '274:': [3943], '12605-12610Google': [3944], '38Yujiri': [3946], 'Sather': [3948], 'Science.': [3954, 4270], '282:': [3956], '1911-1914Google': [3957], '39Schlesinger': [3959], 'Front.': [3967], 'Biosci.': [3968], 'D1181-D1186Google': [3971], 'acts': [3980], 'MEKK1,': [3985], 'vitrowith': [4003], 'coupled': [4005], 'enhance': [4016], 'non-inhibitor-pretreated': [4023], '4': [4026], 'C).': [4027], 'observation': [4029], 'interpreted': [4032], 'indicate': [4034], 'act': [4040], 'MKK4,': [4045], 'does': [4047], 'preclude': [4049], 'MEKKs': [4054], 'MKK4.': [4059, 4090], 'composed': [4063], 'recombinant': [4065, 4095, 4106], 'components,': [4066], 'members': [4071], '(MEKK1/MKK4/JNK/c-Jun),': [4077], 'developed': [4079], 'modulates': [4085], 'MEKK1-mediated': [4087], 'ATP': [4102], 'measured.': [4104], 'MKK4/JNK': [4117], 'c-Jun;': [4119], 'absence,': [4123], 'moderate': [4127], 'ability': [4128], 'activate': [4130], '(Fig.5),': [4134], 'confirming': [4136], 'showing': [4139], 'reconstitution': [4143], 'behaves': [4144], 'robustly,': [4145], 'requires': [4146], 'amplification': [4152], 'preceding': [4155], 'signal': [4156], '(67Gerwins': [4157], 'Blank': [4159], 'J.L.': [4160], '272:': [4167], '8288-8295Google': [4168], 'characteristics': [4178], 'change.': [4183], 'unable': [4186], 'detect': [4188], 'fully': [4198], 'components.': [4207], 'inclusion': [4209], 'inhibited': [4215], 'MEKK1-induced': [4216], 'sequential': [4222], 'substrates': [4223], 'reduced': [4228], 'activated.': [4234], 'fact,': [4236], 'slight': [4245], 'detected,': [4251], '(40Derijard': [4256], 'Raingeaud': [4258], 'Barrett': [4260], 'T.,': [4261], 'Wu,': [4262], 'I.H.': [4263], 'Han': [4264, 4297], 'Ulevitch': [4266], 'R.J.': [4267, 4269], 'Davis': [4268], '267:': [4272], '682-685Google': [4273], 'involvement': [4279], 'p38-regulated': [4282], 'MEK1': [4287], 'MEK2': [4289], '(41Westermarck': [4291], 'Kallunki': [4295], 'Kahari': [4299], 'V.M.': [4300], '21:': [4305], '2373-2383Google': [4306], 'raised': [4308], 'phosphatase.': [4325], 'investigated': [4328], 'PP1/PP2A': [4333], '(Fig.6': [4359], 'A),': [4360], 'exposure,': [4380]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056671431', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-11T12:45:51.081199', 'created_date': '2016-06-24'}