Publication Information

{'id': 'https://openalex.org/W2056615779', 'doi': 'https://doi.org/10.1371/journal.pone.0067431', 'title': 'LKB1 Inhibits Breast Cancer Partially through Repressing the Hedgehog Signaling Pathway', 'display_name': 'LKB1 Inhibits Breast Cancer Partially through Repressing the Hedgehog Signaling Pathway', 'publication_year': 2013, 'publication_date': '2013-07-04', 'ids': {'openalex': 'https://openalex.org/W2056615779', 'doi': 'https://doi.org/10.1371/journal.pone.0067431', 'mag': '2056615779', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23861764', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3701543'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0067431', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067431&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067431&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103127219', 'display_name': 'Zhigang Zhuang', 'orcid': 'https://orcid.org/0000-0002-7827-4402'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhigang Zhuang', 'raw_affiliation_strings': ['Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine Shanghai, China.', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100437103', 'display_name': 'Kai Wang', 'orcid': 'https://orcid.org/0000-0003-2298-4816'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Kai Wang', 'raw_affiliation_strings': ['TONGJI UNIVERSITY'], 'affiliations': [{'raw_affiliation_string': 'TONGJI UNIVERSITY', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101800547', 'display_name': 'Xiaolin Cheng', 'orcid': 'https://orcid.org/0000-0002-8420-1058'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaolin Cheng', 'raw_affiliation_strings': ['TONGJI UNIVERSITY'], 'affiliations': [{'raw_affiliation_string': 'TONGJI UNIVERSITY', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012176380', 'display_name': 'Xueying Qu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xueying Qu', 'raw_affiliation_strings': ['TONGJI UNIVERSITY'], 'affiliations': [{'raw_affiliation_string': 'TONGJI UNIVERSITY', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014876857', 'display_name': 'Beiqi Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Beiqi Jiang', 'raw_affiliation_strings': ['TONGJI UNIVERSITY'], 'affiliations': [{'raw_affiliation_string': 'TONGJI UNIVERSITY', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101808038', 'display_name': 'Zhengdong Li', 'orcid': 'https://orcid.org/0000-0001-9167-3742'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhengdong Li', 'raw_affiliation_strings': ['TONGJI UNIVERSITY'], 'affiliations': [{'raw_affiliation_string': 'TONGJI UNIVERSITY', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100538558', 'display_name': 'Jianming Luo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianming Luo', 'raw_affiliation_strings': ['Fudan University'], 'affiliations': [{'raw_affiliation_string': 'Fudan University', 'institution_ids': ['https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079128498', 'display_name': 'Zhi‐Ming Shao', 'orcid': 'https://orcid.org/0000-0001-8781-2455'}, 'institutions': [{'id': 'https://openalex.org/I4210098264', 'display_name': 'Breast Cancer Care', 'ror': 'https://ror.org/00w85kx21', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210098264']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Zhiming Shao', 'raw_affiliation_strings': ['Breast Cancer Surgery'], 'affiliations': [{'raw_affiliation_string': 'Breast Cancer Surgery', 'institution_ids': ['https://openalex.org/I4210098264']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057907715', 'display_name': 'Tao Duan', 'orcid': 'https://orcid.org/0000-0001-5320-4611'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Duan', 'raw_affiliation_strings': ['TONGJI UNIVERSITY'], 'affiliations': [{'raw_affiliation_string': 'TONGJI UNIVERSITY', 'institution_ids': ['https://openalex.org/I116953780']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 1.934, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.757854, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '7', 'first_page': 'e67431', 'last_page': 'e67431'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9726, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9586, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.9763009}, {'id': 'https://openalex.org/keywords/cyclopamine', 'display_name': 'Cyclopamine', 'score': 0.95739806}, {'id': 'https://openalex.org/keywords/gli1', 'display_name': 'GLI1', 'score': 0.9348339}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.71021116}], 'concepts': [{'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.9763009}, {'id': 'https://openalex.org/C2777605378', 'wikidata': 'https://www.wikidata.org/wiki/Q3271319', 'display_name': 'Cyclopamine', 'level': 4, 'score': 0.95739806}, {'id': 'https://openalex.org/C2779933373', 'wikidata': 'https://www.wikidata.org/wiki/Q14886430', 'display_name': 'GLI1', 'level': 4, 'score': 0.9348339}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.7661722}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.74382675}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.71021116}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6686238}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.5877915}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.54654455}, {'id': 'https://openalex.org/C2776637008', 'wikidata': 'https://www.wikidata.org/wiki/Q14860072', 'display_name': 'Sonic hedgehog', 'level': 3, 'score': 0.514997}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.51108795}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4886823}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34985352}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.31657702}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.30871856}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.30323368}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09779504}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002934', 'descriptor_name': 'Cinnamates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002934', 'descriptor_name': 'Cinnamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072079', 'descriptor_name': 'Patched Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072081', 'descriptor_name': 'Patched-1 Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072086', 'descriptor_name': 'Smoothened Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014704', 'descriptor_name': 'Veratrum Alkaloids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014704', 'descriptor_name': 'Veratrum Alkaloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071676', 'descriptor_name': 'Zinc Finger Protein GLI1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0067431', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067431&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/adfd943d0de546f2b63182ab8104525d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3701543', 'pdf_url': 'https://europepmc.org/articles/pmc3701543?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701543', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23861764', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0067431', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067431&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1573024086', 'https://openalex.org/W1619256199', 'https://openalex.org/W1918990441', 'https://openalex.org/W1975584335', 'https://openalex.org/W1999500450', 'https://openalex.org/W2007859564', 'https://openalex.org/W2026889598', 'https://openalex.org/W2030013561', 'https://openalex.org/W2030199762', 'https://openalex.org/W2043289157', 'https://openalex.org/W2058594499', 'https://openalex.org/W2059456940', 'https://openalex.org/W2063675413', 'https://openalex.org/W2085076473', 'https://openalex.org/W2091275560', 'https://openalex.org/W2100868792', 'https://openalex.org/W2101859789', 'https://openalex.org/W2128670495', 'https://openalex.org/W2138391136', 'https://openalex.org/W2138654578', 'https://openalex.org/W2327039151', 'https://openalex.org/W2422644941'], 'related_works': ['https://openalex.org/W4245412862', 'https://openalex.org/W2790444686', 'https://openalex.org/W2474599166', 'https://openalex.org/W2089766172', 'https://openalex.org/W2074863882', 'https://openalex.org/W2056615779', 'https://openalex.org/W2049817302', 'https://openalex.org/W2021390830', 'https://openalex.org/W2007859564', 'https://openalex.org/W1973523868'], 'abstract_inverted_index': {'Constitutive': [0], 'activation': [1, 40], 'of': [2, 14, 37, 76, 89, 101, 144, 153, 166, 184, 192, 205, 220, 228, 247], 'the': [3, 12, 74, 99, 112, 142, 154, 164, 176, 181, 193, 203, 245], 'Hedgehog': [4], '(Hh)': [5], 'signaling': [6, 39, 263], 'pathway': [7], 'has': [8, 51], 'been': [9, 52], 'implicated': [10], 'in': [11, 43, 61, 83, 132, 175, 189, 196, 264], 'development': [13], 'many': [15, 62], 'human': [16, 197], 'malignancies.': [17], 'Hh': [18, 38, 80, 113, 155, 185, 214, 232, 248, 262], 'targets,': [19], 'such': [20], 'as': [21, 163], 'Patched': [22], '(PTCH),': [23], 'smoothened': [24], '(SMO),': [25], 'Sonic': [26], 'hedgehog': [27], '(SHH)': [28], 'and': [29, 41, 57, 92, 116, 126, 180], 'glioma-associated': [30, 127], 'oncogene': [31, 128], 'homologue': [32, 129], '1': [33, 130], '(GLI1),': [34], 'are': [35, 241], 'markers': [36], 'expressed': [42, 225], 'most': [44], 'Hh-associated': [45], 'tumors.': [46], 'The': [47, 105], 'protein': [48, 195], 'kinase': [49], 'LKB1': [50, 72, 96, 125, 139, 161, 170, 194, 229, 240, 256], 'shown': [53, 109], 'to': [54, 79, 110], 'slow': [55], 'proliferation': [56], 'induce': [58], 'cell-cycle': [59], 'arrest': [60], 'cell': [63, 136, 145], 'lines.': [64, 137], 'In': [65, 94, 168, 234], 'this': [66, 235], 'study,': [67, 236], 'we': [68, 119, 237], 'observed': [69, 121], 'that': [70, 160, 209, 224, 239, 255], 'activated': [71], 'decreased': [73], 'expression': [75, 100, 182, 204, 219, 246], 'factors': [77, 114], 'related': [78, 249], 'reporter': [81], 'activity': [82], 'MDA-MB-231': [84], 'breast': [85, 134, 198, 210], 'cancer': [86, 135], 'cells,': [87], 'including': [88], 'SMO,': [90, 157], 'SHH': [91], 'GLI1.': [93], 'contrast,': [95], 'siRNA': [97, 140, 171], 'increased': [98, 172], 'these': [102], 'target': [103], 'genes.': [104], 'same': [106], 'results': [107, 188], 'were': [108], 'inhibit': [111, 258], 'Sufu': [115], 'Hip.': [117], 'Furthermore,': [118], 'also': [120], 'negative': [122], 'correlation': [123], 'between': [124], '(GLI1)': [131], 'three': [133], 'Meanwhile,': [138], 'rescued': [141], 'inhibition': [143], 'growth': [146, 174], 'by': [147, 260], "3-Keto-N-(aminoethyl-N'-aminocaproyldihydrocinnamoyl)": [148], 'cyclopamine': [149], '(KAAD-cyclopamine),': [150], 'an': [151], 'antagonist': [152], 'element': [156], 'which': [158], 'suggests': [159], 'acts': [162], 'downstream': [165], 'SMO.': [167], 'vivo,': [169], 'tumor': [173], 'mammary': [177], 'fat': [178], 'pad,': [179], 'levels': [183, 227], 'displayed': [186], 'similar': [187], 'vitro.': [190], 'Overexpression': [191], 'cancers': [199], 'is': [200], 'associated': [201], 'with': [202, 212, 244], 'Hh.': [206], 'We': [207], 'found': [208], 'carcinomas': [211], 'detectable': [213], 'had': [215, 230], 'weak': [216], 'or': [217], 'undetectable': [218, 231], 'LKB1,': [221], 'whereas': [222], 'tumors': [223], 'high': [226], 'signaling.': [233], 'find': [238], 'negatively': [242], 'correlated': [243], 'transcription': [250], 'factors.': [251], 'These': [252], 'findings': [253], 'suggest': [254], 'may': [257], 'tumorigenesis': [259], 'regulating': [261], 'certain': [265], 'cancers.': [266]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056615779', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 9}], 'updated_date': '2024-12-17T13:23:43.335620', 'created_date': '2016-06-24'}