Enantioselective Conjugate Addition of Dialkylzinc Reagents to Cyclic and Acyclic Enones Catalyzed by Chiral Copper Complexes of New Phosphorus Amidites

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Duration: 3 min 30 s
Description: Monodentate phosphorus amidites like 1 and Cu(OTf)2 provide access to the first chiral complexes that catalyze the enantioselective conjugate addition of organozinc reagents to cyclic as well as acyclic enones. The ligand-accelerated process affords β-substituted ketones in excellent yields and with high ee values. Functional groups in the zinc reagent are tolerated.
André H. M. de Vries; Auke Meetsma; Ben L. Feringa
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