Title: Ionic Liquid–Mediated One-Pot Synthesis of 5-(Trifluoromethyl)-4,7-dihydrotetrazolo[1,5-<i>a</i>]pyrimidine Derivatives
Abstract:Abstract A facile one-pot synthesis of 5-(trifluoromethyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine derivatives is described via a three-component reaction of aldehydes with 5-aminotetrazole and ethyl 4,...Abstract A facile one-pot synthesis of 5-(trifluoromethyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine derivatives is described via a three-component reaction of aldehydes with 5-aminotetrazole and ethyl 4,4,4-trifluoro-3-oxobutanoate or 4,4,4-trifluoro-1-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, good yields, ecofriendliness, and recyclability of the solvent. Keywords: Cyclizationionic liquidtetrazolo[1,5-a]pyrimidinetrifluoromethylated ACKNOWLEDGMENTS We are grateful for financial support by the Natural Science Foundation of China (Nos. 20672090 and 200810102050), the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (09KJA430003), the Natural Science Foundation of Xuzhou City (XM09B016), the Graduate Foundation of Xuzhou Normal University (09YLB030), and the Qing Lan Project (08QLT001). Notes a [byp+][],1-butylpyridinium tetrafluoroborate, [bmim+][], 3-butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate. b Isolated yield. a [bmim+][] was used as solvent. b Isolated yield. a Isolated yield. a Isolated yield.Read More
Publication Year: 2012
Publication Date: 2012-05-29
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 23
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot