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333], 'degenerative': [42, 337], 'cartilage': [43, 105, 150, 292, 338], 'diseases.': [44, 339], 'Introduction:': [45], 'Prostaglandin': [46], 'E2': [47], '(PGE2)': [48], 'exhibits': [49], 'pleiotropic': [50], 'effects': [51, 70, 114, 296], 'various': [53], 'types': [54, 59], 'of': [55, 60, 67, 71, 84, 106, 115, 125, 142, 158, 176, 203, 208, 235, 267, 274, 280, 297, 318, 336], 'tissue': [56], 'through': [57, 129, 301, 313], 'four': [58], 'receptors,': [61], 'EP1-4.': [62], 'We': [63], 'examined': [64, 91, 153], 'expression': [66, 83, 201], 'EPs': [68], 'agonists': [72, 116, 181], 'each': [74, 85, 118, 183], 'EP': [75, 86, 170, 184], 'on': [76, 146], 'chondrocytes.': [78], 'Materials': [79], 'Methods:': [81], 'The': [82, 139, 233], 'chondrocytes': [89, 147, 247, 260, 289], 'by': [92, 135, 149, 211, 238, 248, 291], 'immunohistochemistry': [93], 'RT-PCR.': [95], 'A': [96, 120], 'chondrocyte': [97], 'cell': [98, 282], 'line,': [99], 'MMA2,': [100], 'established': [102], 'from': [103], 'p53−/−': [107], 'mice': [108], 'used': [110], 'to': [111], 'analyze': [112], 'EP.': [119], 'search': [121], 'molecules': [123], 'downstream': [124], 'signal': [128, 300, 312], 'made': [134], 'cDNA': [136], 'microarray': [137], 'analysis.': [138, 251], 'growth-promoting': [140, 217, 295], 'effect': [141], 'surrounded': [148, 290], 'matrix': [151], 'an': [155, 262, 278], 'organ': [156, 272], 'culture': [157, 273], 'rat': [159, 275], 'femora.': [160], 'Results': [161], 'Conclusion:': [163], 'Treatment': [175], 'MMA2': [177, 204], 'cells': [178], 'with': [179, 254], 'specific': [180], 'showed': [185, 261, 277], 'that': [186, 309], 'only': [187], 'significantly': [191], 'levels': [195], 'dose-dependent': [198], 'manner.': [199], 'Gene': [200], 'profiling': [202], 'revealed': [205], 'set': [207], 'genes': [209, 220, 237], 'upregulated': [210], 'agonist,': [214, 257], 'including': [215], 'several': [216], 'apoptosis-protecting': [219], 'such': [221], 'cyclin': [224], 'D1,': [225], 'fibronectin,': [226], 'integrin': [227], 'α5,': [228], 'AP2α,': [229], '14-3-3γ': [231], 'genes.': [232], 'upregulation': [234], 'these': [236], 'confirmed': [243], 'human': [245, 258], 'quantitative': [249], 'mRNA': [250], 'On': [252], 'treatment': [253, 335], 'increase': [263, 279], 'incorporation': [266], '5-bromo-2-deoxyuracil': [268], '(BrdU),': [269], 'femora': [276], 'proliferating': [281], 'nuclear': [283], 'antigen': [284], '(PCNA)': [285], 'staining': [286], 'matrix,': [293], 'suggesting': [294], 'These': [306], 'results': [307], 'suggested': [308], 'enhances': [315], 'growth': [317], 'is': [325], 'candidate': [327], 'new': [330], 'compound': [332]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056376265', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-11T05:46:25.956060', 'created_date': '2016-06-24'}