Publication Information

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5681, 5766, 5771, 5815, 5847, 5861, 5870, 5902, 6008, 6012, 6031, 6041, 6062, 6073], 'tumor': [7, 182, 535], 'suppressor': [8, 183, 536], 'proteins': [9, 184, 1157, 2296], 'have': [10, 185, 655, 1030, 1406, 1470, 1721, 3553, 4187, 4328, 5124, 5402, 5419, 5622], 'been': [11, 186, 913, 921, 1098, 1407, 1471, 2843, 3619, 4396, 4543, 4972, 5050, 5355, 5444, 5623, 5651], 'shown': [12, 187, 656, 765, 922, 1031, 1099, 2742, 2812, 2844, 3554, 3620, 4397, 4973, 5051, 5125, 5356, 5445, 5652], 'to': [13, 188, 766, 775, 923, 975, 1035, 1100, 1138, 1546, 1567, 1582, 1682, 1715, 2053, 2121, 2165, 2495, 2612, 2646, 2772, 3134, 3160, 3288, 3290, 3464, 3715, 3847, 3863, 4113, 4127, 4398, 4404, 4420, 4636, 4728, 4788, 4858, 4902, 4929, 5052, 5130, 5357, 5421, 5618, 5886, 6002, 6025, 6050], 'negatively': [14, 97, 189, 272, 1206, 3558, 5131, 6010], 'regulate': [15, 143, 190, 318, 983, 1036, 3672, 4128, 4421, 4789, 4859, 5132, 5214, 5619, 6011], 'cell': [16, 100, 123, 132, 147, 173, 191, 275, 298, 307, 322, 348, 355, 358, 455, 495, 667, 701, 935, 937, 939, 942, 984, 986, 989, 992, 1004, 1007, 1024, 1039, 1041, 1044, 1105, 1150, 1163, 1209, 1231, 1240, 2197, 2225, 2358, 3560, 3627, 3640, 3794, 3818, 3887, 3904, 4138, 4179, 4196, 4252, 4300, 4335, 4352, 4376, 4390, 4539, 4554, 4569, 4587, 4593, 4623, 4659, 4676, 4680, 4738, 4756, 4793, 4806, 4815, 4824, 4866, 4907, 4934, 4968, 4976, 5005, 5063, 5090, 5117, 5133, 5347, 5351, 5409, 5430, 5512, 5620], 'growth': [17, 192, 496, 668, 943, 4412, 5206, 5431, 5660], 'through': [18, 110, 149, 193, 285, 324, 991, 1046, 1219, 3004, 3550, 3562, 3675, 3928, 4141, 4869, 4922, 5217, 5464, 5663, 5876], 'inhibition': [19, 194, 672, 3563, 4894, 4949, 5137], 'of': [20, 24, 68, 76, 92, 106, 155, 164, 169, 195, 199, 243, 251, 267, 281, 330, 339, 344, 354, 374, 412, 482, 494, 548, 554, 666, 673, 697, 759, 808, 930, 979, 1052, 1143, 1146, 1162, 1193, 1201, 1215, 1602, 1678, 1687, 1697, 1761, 1763, 1815, 1837, 1842, 2023, 2063, 2126, 2137, 2285, 2314, 2481, 2523, 2537, 2555, 2583, 2659, 2720, 2782, 2803, 2948, 3010, 3094, 3148, 3170, 3228, 3269, 3313, 3325, 3328, 3338, 3341, 3426, 3436, 3480, 3484, 3500, 3531, 3537, 3544, 3564, 3623, 3630, 3643, 3725, 3741, 3770, 3775, 3779, 3840, 3850, 3869, 3874, 3877, 3924, 3988, 4062, 4087, 4093, 4125, 4147, 4151, 4158, 4175, 4185, 4248, 4287, 4320, 4345, 4358, 4535, 4668, 4726, 4743, 4750, 4764, 4784, 4846, 4875, 4895, 4950, 4984, 4995, 5116, 5121, 5138, 5199, 5343, 5365, 5407, 5426, 5435, 5476, 5511, 5521, 5542, 5611, 5632, 5644, 5779, 5994, 6007, 6039, 6054, 6057, 6081, 6098, 6111, 6113, 6140], 'the': [21, 74, 99, 167, 196, 249, 274, 342, 352, 378, 492, 546, 648, 695, 757, 903, 980, 1000, 1110, 1160, 1199, 1208, 1269, 1276, 1300, 1543, 1646, 1660, 1673, 1679, 1695, 1891, 1987, 2001, 2007, 2277, 2431, 2488, 2514, 2553, 2562, 2614, 2674, 2718, 2746, 2780, 2801, 3011, 3019, 3032, 3145, 3162, 3175, 3225, 3329, 3336, 3432, 3476, 3498, 3538, 3697, 3760, 3815, 3825, 3851, 3857, 3867, 3870, 3878, 3885, 3890, 3943, 3959, 3999, 4022, 4156, 4173, 4246, 4351, 4401, 4533, 4748, 4844, 4883, 4962, 4992, 5030, 5042, 5100, 5114, 5330, 5341, 5405, 5423, 5433, 5473, 5509, 5609, 5642, 5776, 5810, 5846, 5856, 5883, 5888, 5992, 6027, 6036, 6055, 6086, 6141], 'mammalian': [22, 197, 410, 1883], 'target': [23, 91, 198, 266, 411, 481, 3778], 'rapamycin': [25, 200, 483], '(mTOR)': [26, 201, 484], 'pathway.': [27, 202], 'Focal': [28, 203, 1009], 'adhesion': [29, 204, 416, 918, 993, 1005, 1010, 4180, 4253, 4338, 4540, 4910, 4977, 5348, 5352], 'kinase': [30, 36, 70, 79, 205, 211, 245, 254, 392, 395, 469, 680, 826, 831, 905, 1011, 1017, 1195, 1906, 3092, 3146, 3366, 4324, 4347, 5675], '(FAK)': [31, 206, 1012], 'is': [32, 59, 109, 129, 207, 234, 284, 304, 360, 366, 543, 997, 1013, 1218, 1237, 1590, 1689, 1699, 3096, 3236, 3535, 3667, 3927, 4091, 4664, 4767, 4812, 4891, 4897, 4944, 4959, 5079, 5097, 5506, 5613, 5768, 5782, 5882, 5916, 6000], 'a': [33, 39, 48, 119, 160, 208, 214, 223, 294, 335, 361, 551, 578, 643, 662, 928, 1014, 1020, 1102, 1170, 1228, 1591, 1637, 1834, 2020, 2273, 2633, 2664, 2850, 2989, 3027, 3316, 3351, 3415, 3460, 3637, 3832, 3848, 3864, 3881, 4066, 4109, 4183, 4386, 4550, 4563, 4597, 4802, 4822, 4988, 5002, 5197, 5337, 5359, 5363, 5448, 5517, 5638, 5684, 5989], 'cytoplasmic': [34, 209], 'tyrosine': [35, 210, 769, 904, 909, 3088, 3339, 5819, 5857, 5862, 5889], 'that': [37, 57, 66, 103, 116, 140, 212, 232, 241, 278, 291, 315, 377, 657, 982, 1018, 1032, 1179, 1191, 1212, 1225, 1658, 1717, 1737, 2708, 2833, 2845, 2941, 2985, 2998, 3086, 3113, 3144, 3231, 3265, 3281, 3309, 3396, 3411, 3494, 3529, 3555, 3621, 3633, 3669, 3768, 3838, 4040, 4060, 4085, 4121, 4132, 4189, 4299, 4343, 4383, 4547, 4559, 4592, 4622, 4652, 4730, 4780, 4799, 4833, 4843, 4863, 4942, 4957, 4974, 4982, 4998, 5126, 5196, 5333, 5446, 5508, 5630, 5653, 5814, 5869, 5912, 5973, 5984, 6004, 6069], 'plays': [38, 118, 213, 293, 487, 753, 1019, 1227, 3790, 4168, 4385, 4549, 4654, 4733, 4801, 5086, 5336, 5637, 5683], 'critical': [40, 215, 754, 5338, 5360, 5917, 6138], 'role': [41, 121, 163, 216, 296, 338, 490, 1022, 1103, 1229, 3638, 3792, 4171, 4388, 4531, 4552, 4564, 4657, 4736, 4804, 5003, 5056, 5088, 5339, 5361, 5425, 5518, 5640, 5686, 5990], 'in': [42, 122, 166, 217, 297, 341, 491, 550, 583, 694, 756, 773, 815, 927, 1023, 1104, 1159, 1186, 1230, 1559, 1608, 1768, 1824, 1849, 1862, 1872, 2014, 2031, 2038, 2123, 2133, 2290, 2311, 2338, 2419, 2436, 2478, 2580, 2617, 2632, 2717, 2735, 2743, 2779, 2808, 2813, 2819, 2839, 2853, 2936, 2960, 3014, 3044, 3185, 3196, 3234, 3304, 3420, 3491, 3497, 3639, 3734, 3781, 3793, 3843, 3866, 3884, 3889, 3906, 3948, 3974, 4036, 4068, 4072, 4078, 4155, 4172, 4306, 4389, 4532, 4553, 4565, 4576, 4600, 4603, 4616, 4630, 4642, 4658, 4675, 4737, 4758, 4769, 4805, 4953, 4964, 4991, 5004, 5041, 5057, 5089, 5113, 5340, 5362, 5415, 5432, 5460, 5519, 5641, 5687, 5991, 6030, 6043], 'integrin': [43, 218, 5438, 5468], 'signaling.': [44, 219, 5349, 5439], 'Here': [45, 220, 4721, 5866], 'we': [46, 64, 113, 221, 239, 288, 1152, 1168, 1189, 1222, 2671, 2797, 2905, 3025, 3279, 3356, 3765, 3900, 3932, 4029, 4620, 4722, 4797, 4820, 4841, 5867, 5971], 'identify': [47, 222, 4821, 5887, 6026], 'novel': [49, 224, 1171, 4823, 5107], 'interaction': [50, 151, 225, 326, 1048, 1172, 2666, 2802, 3152, 3243, 3253, 3275, 3318, 3330, 3470, 4143, 4826, 4871, 4924, 5466, 5878], 'between': [51, 226, 1173, 2667, 3319, 3331, 4025, 4827], 'FAK': [52, 69, 104, 117, 141, 227, 244, 279, 292, 316, 1033, 1095, 1144, 1174, 1185, 1194, 1213, 1226, 1267, 1279, 1830, 1905, 2310, 2660, 2668, 2678, 2736, 2753, 2805, 2816, 2838, 2908, 2919, 2942, 2961, 2970, 2986, 2999, 3015, 3037, 3040, 3078, 3095, 3099, 3109, 3114, 3125, 3149, 3163, 3172, 3219, 3255, 3284, 3320, 3323, 3332, 3365, 3407, 3419, 3427, 3441, 3449, 3454, 3468, 3487, 3534, 3542, 3634, 3670, 3689, 3727, 3742, 3771, 3789, 3807, 3841, 3871, 3891, 3907, 3922, 3963, 3989, 4006, 4026, 4031, 4063, 4088, 4122, 4133, 4152, 4167, 4190, 4256, 4259, 4307, 4321, 4346, 4359, 4384, 4548, 4663, 4731, 4744, 4762, 4781, 4800, 4828, 4847, 4864, 4890, 4912, 4918, 4948, 4999, 5034, 5111, 5875, 5900, 5975, 5978, 5985, 6005, 6033, 6118], 'show': [56, 65, 231, 240, 1169, 1178, 4798, 4832, 4842, 5868], 'phosphorylated': [60, 235, 1183, 1283, 3400, 4837, 5873], 'by': [61, 172, 236, 347, 369, 545, 670, 1002, 1184, 1525, 1555, 1560, 1564, 1578, 1712, 1978, 1991, 2173, 2195, 2223, 2241, 2342, 2346, 2533, 2606, 2653, 2699, 2738, 2764, 2766, 3055, 3106, 3168, 3189, 3343, 3387, 3401, 3406, 3486, 3533, 3709, 3823, 4005, 4161, 4178, 4195, 4251, 4258, 4291, 4538, 4568, 4673, 4838, 5032, 5135, 5346, 5437, 5607, 5615, 5634, 5659, 5666, 5690, 5770, 5773, 5874, 5898, 6032], 'FAK.': [62, 237, 3245, 3277, 3344, 4839, 5880], 'Furthermore,': [63, 238, 1188, 3246, 5044, 5764], 'overexpression': [67, 242, 1192, 3425, 3622, 3724, 3740, 3769, 3839, 3987, 4061, 4086, 4319, 4344, 4357, 4742, 4983, 5976], 'dead': [71, 246, 1196, 1907, 3367, 4325, 4348], 'mutant': [72, 247, 1197, 1908, 3368, 3429, 3456, 3463, 4112, 4326, 4349, 4746], 'inhibits': [73, 248, 1198, 4747, 5453], 'phosphorylation': [75, 108, 154, 250, 283, 329, 772, 910, 1051, 1200, 1217, 2125, 3090, 3340, 3352, 3416, 3434, 3478, 3483, 3530, 3674, 3733, 3755, 3774, 3926, 3978, 3993, 4004, 4071, 4130, 4146, 4177, 4203, 4250, 4303, 4333, 4364, 4374, 4423, 4557, 4575, 4602, 4629, 4641, 4749, 4874, 4905, 4932, 4952, 4966, 4980, 5216, 5345, 5631, 5665, 5682, 5767, 5772, 5781, 5822, 5863, 6006, 6028, 6042], 'ribosomal': [77, 252, 678, 824, 5673], 'S6': [78, 253, 419, 679, 825, 4626, 4638, 5674], '(S6K)': [80, 255, 681], 'eukaryotic': [82, 257, 422, 683], 'initiation': [83, 258, 423, 684], 'factor': [84, 259, 424, 685, 5661], '4E-binding': [85, 260], 'protein-1,': [86, 261], 'two': [87, 262, 1609], 'key': [88, 263, 925], 'mTOR': [89, 170, 264, 345, 674, 816, 4135, 4787, 5139, 5454], '(mammalian': [90, 265], 'rapamycin)': [93, 268], 'downstream': [94, 269, 1054], 'targets,': [95, 270], 'regulates': [98, 273, 1006, 1207, 3559, 4865, 5035, 5901], 'size': [101, 148, 276, 323, 356, 702, 1210, 2359, 2616, 2625, 3561, 3795, 3819, 3868, 3888, 3905, 4139, 4739, 4757, 4867, 5091, 5134, 5621], 'regulation': [105, 168, 280, 343, 493, 696, 758, 1145, 1161, 1214, 3923, 4174, 4534, 4682, 4763, 5115, 5342, 5434, 5643, 5689, 5993], 'S6K': [107, 125, 134, 144, 282, 300, 309, 319, 1107, 1147, 1202, 1216, 1233, 1242, 1319, 3545, 3644, 3673, 3714, 3732, 3745, 3763, 3925, 3977, 3992, 4003, 4070, 4115, 4129, 4159, 4176, 4202, 4249, 4302, 4332, 4354, 4363, 4373, 4392, 4422, 4536, 4556, 4566, 4574, 4601, 4661, 4751, 4765, 4790, 4808, 4817, 4860, 4904, 4931, 4951, 4965, 4979, 5007, 5036, 5046, 5084, 5143, 5215, 5344, 6019], 'TSC2.': [111, 286, 1176, 1220, 3008, 3102, 3154, 3322, 3481, 3676, 4148, 4876, 5894], 'Finally,': [112, 287, 1221, 3482, 4081, 4819], 'provide': [114, 159, 289, 334, 1223, 4723], 'data': [115, 290, 2983, 3879, 4880], 'positive': [120, 295, 4387, 4551, 4803], 'adhesion-induced': [124, 299, 1232, 4301, 4353, 4391, 4555, 4807], 'phosphorylation,': [126, 301, 1234, 3746, 3764, 4809, 4861], 'whereas': [127, 302, 1235, 3124, 3212, 4810, 5677], 'required': [130, 305, 1238, 3097, 3240, 3272, 4813, 4945, 4960], 'for': [131, 306, 539, 647, 907, 1154, 1239, 1983, 1997, 2040, 2060, 2160, 2175, 2206, 2232, 2243, 2282, 2320, 2456, 2475, 2500, 2570, 2599, 2609, 3098, 3241, 3273, 3354, 3418, 3469, 4284, 4814, 4946, 4961, 5329, 5860, 5918, 6059, 6085, 6104, 6117, 6137], 'suspension-induced': [133, 308, 1241, 4660, 4816], 'inactivation.': [135, 310, 1243, 4662, 4818], 'Together,': [136, 311, 2829, 4647], 'these': [137, 312, 2794, 2830, 3262, 3735, 3844, 4118, 4648], 'results': [138, 313, 2831, 3142, 3263, 4119, 4381, 4649], 'suggest': [139, 314, 2832, 2984, 3143, 3264, 4120, 4382, 4651, 4729, 4882], 'might': [142, 317, 3457, 3635, 3671, 4561, 5000, 5471, 5515, 5986, 6009], 'activation': [145, 320, 1148, 3629, 3642, 3718, 4766, 4791, 4994, 5008, 5037, 5047, 5085], 'its': [150, 325, 676, 813, 1047, 3005, 3151, 3717, 3749, 4142, 4530, 4870, 4923, 5141, 5877, 5919], 'with': [152, 327, 1049, 1533, 1539, 1542, 1650, 1725, 1771, 1826, 1852, 1865, 1875, 1882, 2056, 2078, 2086, 2150, 2199, 2227, 2247, 2254, 2307, 2334, 2349, 2365, 2424, 2468, 2490, 2509, 2520, 2575, 2642, 2661, 2679, 2694, 2702, 2712, 2726, 2774, 2788, 2793, 2837, 2912, 2927, 2945, 2975, 2992, 3002, 3007, 3031, 3050, 3058, 3071, 3077, 3101, 3122, 3153, 3174, 3191, 3210, 3218, 3244, 3254, 3276, 3361, 3383, 3390, 3444, 3466, 3471, 3685, 3696, 3712, 3748, 3759, 3802, 3831, 3856, 3898, 3911, 3958, 4095, 4105, 4144, 4265, 4294, 4311, 4852, 4855, 4872, 4925, 5099, 5467, 5879], 'also': [158, 333, 1097, 2732, 2799, 2910, 2957, 3075, 3489, 3766, 3901, 4200, 4732, 4938, 5049, 5104, 5335], 'previously': [161, 336, 1409, 1473, 1613, 1779, 1921, 2372], 'unappreciated': [162, 337], 'signaling': [171, 346, 485, 919, 1055, 4136, 4406, 5353, 5455, 5662], 'adhesion.': [174, 349, 4377], 'Cell': [350, 742, 843, 917, 1085, 1353, 1485, 1626, 1728, 1965, 2354, 2366, 2405, 2689, 3378, 3548, 3606, 3702, 4162, 4272, 4441, 4711, 4909, 5185, 5237, 5705], 'growth,': [351], 'increase': [353], 'or': [357, 1746, 1981, 1994, 2203, 2682, 2754, 2920, 2935, 3038, 3371, 3692, 3809, 3930, 3973, 4049, 4269, 4279, 4323, 4581, 4772, 6074], 'mass,': [359], 'fundamental': [362], 'biological': [363, 5366], 'process': [364], 'mainly': [367, 669], 'regulated': [368, 5658], 'protein': [370, 651, 698, 821, 1363, 2183, 2189, 2248, 3285, 3294, 3946, 5427, 5458, 5679], 'synthesis.': [371], 'Considerable': [372], 'bodies': [373], 'evidence': [375, 1224, 4727], 'indicate': [376, 5629], 'tuberous': [379, 388, 540, 5522], '(TSC)': [382], '2The': [383], 'abbreviations': [384], 'used': [385, 1919, 2132, 3159], 'are:': [386], 'TSC,': [387], 'complex;': [390], 'KD,': [391], 'domain;': [393, 473], 'kd,': [394], 'dead;': [396], 'MEF,': [397, 464], 'myocyte-specific': [398], 'enhancer': [399], 'binding': [400, 426, 687, 3021, 3133, 3164], 'factor;': [401], 'mean': [402, 404, 3826, 3852], 'FSC-H,': [403], 'forward': [405, 3827], 'scatter;': [406], 'FN,': [407], 'fibronectin;': [408], 'mTOR,': [409, 3780], 'rapamycin;': [413], 'FAK,': [414, 3024, 3211, 3355, 3363, 3403, 3688], 'focal': [415], 'kinase;': [417, 420], 'S6K,': [418, 3631, 4996], '4EBP-1,': [421, 1344, 3776], '4E': [425, 686], 'protein-1;': [427], 'GST,': [428], 'glutathione': [429], 'S-transferase;': [430], 'HA,': [431], 'hemagglutinin;': [432], 'RNAi,': [433, 1914], 'RNA-mediated': [434], 'interference;': [435], 'DMEM,': [436, 2643], "Dulbecco's": [437, 2015, 2032], 'modified': [438, 2016, 2033, 5614], "Eagle's": [439, 2017, 2034], 'medium;': [440], 'FBS,': [441, 2493, 2512, 2578], 'fetal': [442], 'bovine': [443], 'serum;': [444], 'KO,': [445], 'knock': [446], 'out;': [447], 'Ad,': [448], 'adenovirus;': [449], 'PBS,': [450, 2491, 2510, 2524, 2576], 'phosphate-buffered': [451, 2080], 'saline;': [452], 'FACS,': [453, 2561], 'fluorescence-activated': [454], 'sorter;': [456], 'IP,': [457], 'immunoprecipitate;': [458], 'NT,': [459], 'N-terminal;': [460], 'GAP,': [461], 'GTPase-activating': [462], 'protein;': [463], 'mouse': [465, 1265, 1270, 1301, 1370], 'embryo': [466], 'fibroblast;': [467], 'KC,': [468], 'domain': [470, 646, 3120, 3127, 3130, 3147, 3233, 4100], 'plus': [471], 'C-terminal': [472], 'CT,': [474], 'C-terminal;': [475], 'VEC,': [476], 'empty': [477, 1748, 2684, 2728, 2756, 2790, 2922, 3373, 3693, 3811, 3858, 4051, 6076], 'vector': [478, 1397, 1402, 1588, 1605, 1648, 1749, 2675, 2685, 2747, 2757, 2916, 2923, 3030, 3033, 3173, 3176, 3360, 3374, 3694, 3698, 3805, 3812, 3936, 3961, 3968, 4052, 6088], 'control.': [479, 4740, 5092], '-mammalian': [480], 'cascade': [486], 'an': [488, 1136, 1261, 1747, 3051, 3059, 3803, 3810, 4050, 4655, 4665, 4734, 5054, 6075], 'essential': [489, 692], '(1Fingar': [497, 5065], 'D.C.': [498, 1428, 5066], 'Blenis': [499, 859, 5067, 5721], 'J.': [500, 593, 603, 726, 736, 741, 784, 839, 860, 1119, 1437, 1481, 1503, 1625, 1964, 2404, 2863, 2873, 3517, 3590, 3600, 3605, 3649, 4227, 4489, 4501, 5013, 5068, 5169, 5179, 5184, 5285, 5297, 5565, 5701, 5722, 5793, 5829, 5929, 5939], 'Oncogene.': [501, 1067, 4214, 4693, 5069], '2004;': [502, 4521, 5070, 5317], '23:': [503, 1420, 5071], '3151-3171Crossref': [504, 5072], 'PubMed': [505, 525, 564, 616, 718, 747, 795, 848, 873, 897, 952, 968, 1071, 1090, 1130, 1422, 1448, 1490, 1514, 1631, 1796, 1941, 1970, 2389, 2410, 2886, 3521, 3582, 3611, 3660, 4218, 4238, 4446, 4466, 4495, 4524, 4697, 4716, 5024, 5073, 5161, 5190, 5242, 5262, 5291, 5320, 5378, 5394, 5500, 5555, 5599, 5710, 5735, 5759, 5804, 5840, 5952], 'Scopus': [506, 526, 565, 617, 719, 748, 796, 849, 874, 898, 953, 969, 1072, 1091, 1131, 1423, 1449, 1491, 1515, 1632, 1797, 1942, 1971, 2390, 2411, 2887, 3522, 3583, 3612, 3661, 4219, 4239, 4447, 4467, 4496, 4525, 4698, 4717, 5025, 5074, 5162, 5191, 5243, 5263, 5292, 5321, 5379, 5395, 5501, 5556, 5600, 5711, 5736, 5760, 5805, 5841, 5953], '(1070)': [507, 5075], 'Google': [508, 528, 567, 619, 632, 721, 750, 798, 851, 876, 900, 955, 971, 1074, 1093, 1133, 1425, 1451, 1493, 1517, 1634, 1799, 1944, 1973, 2392, 2413, 2889, 2902, 3524, 3585, 3614, 3663, 4221, 4241, 4449, 4469, 4498, 4527, 4700, 4719, 5027, 5076, 5164, 5193, 5245, 5265, 5294, 5323, 5381, 5397, 5503, 5558, 5577, 5602, 5713, 5738, 5762, 5807, 5843, 5955, 5968], 'Scholar,': [509, 620, 722, 852, 877, 956, 1075, 1426, 1494, 1945, 2393, 2890, 3586, 4222, 4450, 4470, 4499, 4701, 5165, 5246, 5266, 5295, 5382, 5559, 5578, 5714, 5739, 5956], '6Wullschleger': [510], 'S.': [511, 5487], 'Loewith': [512], 'R.': [513, 597, 740, 1500, 1810, 2867, 3604, 5183, 5495, 5933, 6093], 'Hall': [514], 'M.N.': [515, 858, 5720], 'Cell.': [516, 709, 864, 888, 959, 1417, 1787, 1932, 2380, 3573, 4457, 5152, 5253, 5385, 5726, 5750], '2006;': [517], '124:': [518], '471-484Abstract': [519], 'Full': [520, 522, 713, 715, 790, 792, 868, 870, 892, 894, 963, 965, 1125, 1127, 1443, 1445, 1509, 1511, 1791, 1793, 1936, 1938, 2384, 2386, 3577, 3579, 3655, 3657, 4233, 4235, 4461, 4463, 5019, 5021, 5156, 5158, 5257, 5259, 5389, 5391, 5730, 5732, 5754, 5756, 5799, 5801, 5835, 5837], 'Text': [521, 523, 714, 716, 791, 793, 869, 871, 893, 895, 964, 966, 1126, 1128, 1444, 1446, 1510, 1512, 1792, 1794, 1937, 1939, 2385, 2387, 3578, 3580, 3656, 3658, 4234, 4236, 4462, 4464, 5020, 5022, 5157, 5159, 5258, 5260, 5390, 5392, 5731, 5733, 5755, 5757, 5800, 5802, 5836, 5838], 'PDF': [524, 717, 794, 872, 896, 967, 1129, 1447, 1513, 1795, 1940, 2388, 3581, 3659, 4237, 4465, 5023, 5160, 5261, 5393, 5734, 5758, 5803, 5839], '(4745)': [527], 'Scholar).': [529, 568, 633, 751, 799, 901, 972, 1094, 1134, 1452, 1518, 1635, 1800, 1974, 2414, 2903, 3615, 3664, 4242, 4528, 4720, 5028, 5324, 5398, 5504, 5603, 5763, 5808, 5969], 'TSC1': [530, 569, 635, 2846, 2949, 2955, 2976, 2994, 3003], 'are': [533, 3271, 3495, 5544, 5852, 5904, 6048], 'both': [534, 768, 2993, 5818], 'genes': [537], 'responsible': [538, 906, 5859], 'sclerosis,': [541], 'which': [542, 690, 1003, 1572, 3202, 3861, 3939, 4198, 4927, 5033, 5470, 5543, 5608, 5891, 5899], 'characterized': [544], 'formation': [547, 5915], 'hamartomas': [549], 'wide': [552], 'range': [553], 'tissues': [555], '(4Kwiatkowski': [556, 5547], 'D.J.': [557, 4488, 5284, 5548, 5580], 'Ann.': [558, 5549], 'Hum.': [559, 610, 2880, 5550, 5593, 5946], 'Genet.': [560, 612, 2882, 5551, 5595, 5948], '2003;': [561, 1419, 1788, 2381, 4458, 4492, 5254, 5288, 5552, 5796], '67:': [562, 5553], '87-96Crossref': [563, 5554], '(295)': [566, 5557], 'contain': [572], 'coiled-coil': [573], 'regions': [574], 'can': [576, 4191, 4199, 5871, 5892], 'form': [577, 2849, 2988], 'physical': [579], 'functional': [581, 4023, 5777, 6037], 'vivo': [584, 2124, 2854, 3421], '(7Nellist': [585, 2855, 5921], 'M.': [586, 589, 728, 2856, 2859, 3592, 5171, 5588, 5922, 5925], 'van': [587, 594, 606, 2857, 2864, 2876, 5923, 5930, 5942], 'Slegtenhorst': [588, 2858, 5924], 'Nagelkerken': [590, 2860, 5926], 'B.': [591, 1434, 1616, 1926, 2395, 2861, 4437, 5233, 5927], 'Cheadle': [592, 2862, 5928], 'den': [595, 2865, 5931], 'Snell': [596, 2866, 5932], 'Ouweland': [598, 2868, 5934], 'A.': [599, 601, 724, 734, 1951, 2869, 2871, 3588, 3598, 5167, 5177, 5481, 5935, 5937], 'Reuser': [600, 2870, 5936], 'Sampson': [602, 735, 2872, 3599, 5178, 5938], 'Halley': [604, 2874, 5940], 'D.': [605, 1839, 2875, 4439, 5235, 5941, 6109], 'der': [607, 2877, 5943], 'Sluijs': [608, 2878, 5944], 'P.': [609, 885, 1813, 1957, 2879, 3515, 4429, 5225, 5747, 5790, 5945, 6096], 'Mol.': [611, 863, 1084, 1416, 2881, 4710, 5594, 5725, 5947], '1998;': [613, 629, 2883, 2899, 5949, 5965], '7:': [614, 2884, 5950], '1053-1057Crossref': [615, 2885, 5951], '(496)': [618, 2888, 5954], '8Plank': [621, 2891, 5957], 'T.L.': [622, 1413, 1430, 1947, 2892, 5958], 'Yeung': [623, 782, 1499, 2893, 4434, 5230, 5827, 5959], 'R.S.': [624, 783, 2894, 4435, 5231, 5828, 5960], 'Henske': [625, 2895, 5961], 'E.P.': [626, 2896, 5962], 'Cancer': [627, 1818, 2897, 5572, 5963, 6101], 'Res.': [628, 2898, 5573, 5964], '58:': [630, 2900, 5966], '4766-4770PubMed': [631, 2901, 5967], 'Although': [634, 5399, 5809], 'has': [636, 911, 920, 1096, 2842, 3618, 4395, 4541, 4971, 5048, 5354, 5443, 5650], 'no': [637, 3132, 3251], 'known': [638, 998], 'enzymatic': [639], 'activity,': [640], 'contains': [642, 3203], 'carboxyl-terminal': [644], 'GAP': [645, 6013], 'small': [649], 'G': [650], 'Rheb.': [652], 'Recent': [653], 'studies': [654, 802, 1029, 3552, 4186, 5123, 5401, 5418, 5628, 5910], 'TSC1·TSC2': [658, 3556, 5127, 5218, 5654, 5913, 5981, 5995], 'functions': [660, 1034, 4123, 4782, 4901, 5129], 'as': [661, 1260, 1612, 1778, 1886, 1920, 2065, 2140, 2230, 2272, 2371, 2655, 3066, 3220, 3222, 3350, 3414, 3446, 3448, 3459, 4108, 4182, 4400, 4411, 5062, 5205], 'potent': [663, 5449], 'negative': [664, 3462, 3751, 4000, 4111], 'regulator': [665], 'their': [671, 4856, 5136], 'targets': [677, 5142], 'protein-1': [688], '(4EBP-1),': [689], 'play': [691, 924, 1101, 3636, 4562, 5001, 5053, 5358, 5516, 5988], 'roles': [693, 755, 926, 5406], 'synthesis': [699, 5428, 5459], '(9Potter': [703, 3567, 5146], 'C.J.': [704, 3568, 5147], 'Huang': [705, 3569, 5148], 'H.': [706, 883, 1432, 1961, 3570, 4472, 4476, 5149, 5268, 5272, 5567, 5582, 5592, 5745], 'Xu': [707, 3571, 5150, 6125], 'T.': [708, 732, 837, 1479, 1784, 2377, 3572, 3596, 4433, 4454, 5151, 5175, 5229, 5250, 5561, 5571, 5699], '2001;': [710, 787, 3574, 5153, 5832], '105:': [711, 3575, 5154], '357-368Abstract': [712, 3576, 5155], '(446)': [720, 3584, 4497, 5163, 5293], '15Jaeschke': [723, 3587, 5166], 'Hartkamp': [725, 3589, 5168], 'Saitoh': [727, 3591, 5170], 'Roworth': [729, 3593, 5172], 'W.': [730, 3594, 5173], 'Nobukuni': [731, 3595, 5174], 'Hodges': [733, 3597, 5176], 'Thomas': [737, 3601, 5180], 'G.': [738, 3602, 4474, 5181, 5270], 'Lamb': [739, 3603, 5182], 'Biol.': [743, 785, 844, 1086, 1120, 1418, 1438, 1486, 1504, 1627, 1966, 2406, 3607, 3650, 4228, 4442, 4712, 5014, 5186, 5238, 5706, 5794, 5830], '2002;': [744, 845, 865, 960, 1440, 1487, 1506, 3608, 4443, 5187, 5239, 5386, 5497, 5596, 5707, 5727], '159:': [745, 3609, 5188], '217-224Crossref': [746, 3610, 5189], '(185)': [749, 3613, 5192], 'Phosphorylation': [752, 3324, 3546, 4160], 'signal': [760, 1026, 4669], 'transduction.': [761, 1027], 'initially': [763], 'was': [764, 1250, 1523, 1552, 1573, 1606, 1642, 1669, 2131, 2148, 2185, 2265, 2369, 2444, 2710, 2770, 2817, 2965, 3069, 3074, 3158, 3286, 3488, 3979, 4008, 4304, 4613, 5038], 'undergo': [767, 5817], 'serine': [771, 5821], 'response': [774], 'various': [776, 2425, 3039, 3178, 5616, 6060], 'stimuli': [777, 5617], '(16Aicher': [778, 5823], 'L.D.': [779, 5824], 'Campbell': [780, 5825], 'J.S.': [781, 5826], 'Chem.': [786, 1121, 1439, 1505, 3651, 4229, 5015, 5795, 5831], '276:': [788, 5833], '21017-21021Abstract': [789, 5834], '(80)': [797, 5842], 'Indeed,': [800], 'recent': [801, 5122, 5417], 'identified': [803, 5849], 'multiple': [804], 'serine/threonine': [805, 5853], 'kinases': [806, 3503, 5636, 5848], 'capable': [807, 4092], 'phosphorylating': [809], 'regulating': [812], 'function': [814, 3458, 4399, 4537, 5112, 5475, 5610, 5903, 5920], 'signaling,': [817, 994, 4181], 'including': [818, 934, 5368], 'Akt,': [819, 5667], 'AMP-activated': [820, 5678], 'kinase,': [822, 5670, 5890], 'p90': [823, 5672], '1,': [827, 5676], 'extracellular': [829, 5200, 5668], 'signal-regulated': [830, 5669], '(13Inoki': [832, 1474, 5694], 'K.': [833, 1475, 1498, 1782, 2375, 4452, 4480, 4503, 5248, 5276, 5299, 5485, 5695, 5788], 'Li': [834, 1476, 5696], 'Y.': [835, 1477, 1496, 1594, 1928, 4427, 5223, 5479, 5697, 5786], 'Zhu': [836, 1478, 1783, 2376, 4453, 5249, 5698], 'Wu': [838, 1480, 1619, 2398, 5700], 'Guan': [840, 1414, 1435, 1482, 1501, 1621, 1623, 1760, 1785, 1929, 1962, 2378, 2400, 2402, 4455, 5251, 5702, 5791, 6053], 'K.L.': [841, 1483, 1502, 1622, 1786, 2379, 2401, 4456, 5252, 5703, 5792], 'Nat.': [842, 1082, 1484, 4440, 4708, 5236, 5704], '4:': [846, 1488, 4444, 5240, 5708], '648-657Crossref': [847, 1489, 5709], '(2421)': [850, 1492, 5712], '17Manning': [853, 5715], 'B.D.': [854, 4507, 5303, 5716], 'Tee': [855, 5717], 'A.R.': [856, 5718], 'Logsdon': [857, 5719], 'Cantley': [861, 5723], 'L.C.': [862, 5724], '10:': [866, 5728], '151-162Abstract': [867, 5729], '(1286)': [875, 5737], '20Ma': [878, 5740], 'L.': [879, 1808, 5741, 6091], 'Chen': [880, 5742], 'Z.': [881, 5743], 'Erdjument-Bromage': [882, 5744], 'Tempst': [884, 5746], 'Pandolfi': [886, 5748], 'P.P.': [887, 5749], '2005;': [889, 1087, 1628, 1933, 1967, 2407, 4713, 5751], '121:': [890, 5752], '179-193Abstract': [891, 5753], '(1042)': [899, 5761], 'However,': [902, 2969, 4529, 5029, 5970], 'not': [912, 1720, 2715, 2777, 2826, 2972, 3207, 3301, 3405, 3729, 3738, 4077, 4098, 4103, 4371, 4542, 5039, 5080, 5783, 5905, 5987], 'reported': [914], 'so': [915, 5850], 'far.': [916], 'number': [929, 4184, 5120, 5364], 'important': [931, 4656, 4666, 4735, 5055], 'cellular': [932, 5059], 'processes,': [933, 5060, 5367], 'migration,': [936, 985, 1040, 4677], 'survival,': [938, 987, 4678, 5410], 'proliferation,': [940, 1042, 5411], '(21Giancotti': [944, 5370], 'F.G.': [945, 5371], 'Ruoslahti': [946, 5372], 'E.': [947, 4511, 5307, 5373], 'Science.': [948, 5374, 5496], '1999;': [949, 3518, 5375, 5574], '285:': [950, 5376], '1028-1032Crossref': [951, 5377], '(3829)': [954, 5380], '22Hynes': [957, 5383], 'R.O.': [958, 5384, 5493], '110:': [961, 5387], '673-687Abstract': [962, 5388], '(6955)': [970, 5396], 'In': [973, 1135, 1165, 4795, 4886], 'contrast': [974], 'our': [976, 4380, 4879, 4940, 6044, 6123], 'extensive': [977], 'understanding': [978], 'mechanisms': [981, 1001, 1142, 5606, 5897], 'proliferation': [990, 5064], 'relatively': [995], 'little': [996], 'about': [999, 5110], 'growth.': [1008, 4908, 4935], '125-kDa': [1015], 'protein-tyrosine': [1016], 'major': [1021, 5639, 5685], 'adhesion-mediated': [1025, 3628, 3641, 5006, 5513], 'Numerous': [1028], 'cytoskeleton': [1037], 'organization,': [1038], 'survival': [1045], 'other': [1053, 1155, 1726, 5058, 5635], 'molecules': [1056], '(23Parsons': [1057, 4204, 4683], 'J.T.': [1058, 1118, 3648, 4205, 4226, 4684, 5012], 'Martin': [1059, 4206, 4685], 'K.H.': [1060, 4207, 4686], 'Slack': [1061, 4208, 4687], 'J.K.': [1062, 4209, 4688], 'Taylor': [1063, 4210, 4689], 'J.M.': [1064, 4211, 4690], 'Weed': [1065, 4212, 4691], 'S.A.': [1066, 4213, 4692], '2000;': [1068, 4215, 4694], '19:': [1069, 4216, 4695], '5606-5613Crossref': [1070, 4217, 4696], '(566)': [1073, 4220, 4699], '24Mitra': [1076, 4702], 'S.K.': [1077, 4703], 'Hanson': [1078, 4704], 'D.A.': [1079, 4705], 'Schlaepfer': [1080, 4706], 'D.D.': [1081, 4707], 'Rev.': [1083, 4709], '6:': [1088, 4714], '56-68Crossref': [1089, 4715], '(1983)': [1092, 4718], 'adhesion-stimulated': [1106], 'activation,': [1108], 'although': [1109, 3723, 3986, 4368, 5775], 'underlying': [1111], 'mechanism': [1112, 5031], 'remains': [1113, 5864], 'unknown': [1114], '(25Malik': [1115, 3645, 5009], 'R.K.': [1116, 3646, 4224, 5010], 'Parsons': [1117, 3647, 4225, 5011], '1996;': [1122, 3652, 4230, 5016], '271:': [1123, 3653, 4231, 5017], '29785-29791Abstract': [1124, 3654, 4232, 5018], '(56)': [1132, 3662, 4240, 5026], 'effort': [1137], 'further': [1139, 4020, 4164, 4316], 'explore': [1140], 'potential': [1141, 2665, 5424], 'size,': [1151], 'searched': [1153], 'FAK-interacting': [1156], 'involved': [1158], 'size.': [1164, 4794, 5118], 'this': [1166, 3679, 4611, 5780], 'study': [1167, 5094, 5326, 5812, 5885, 6035], 'We': [1177, 2730, 2914, 3394, 3720, 4315, 6047, 6121], 'could': [1181, 2731, 2798, 2835, 2909, 2943, 2956, 2987, 3216, 3398, 3940, 4835, 5656, 5816], 'be': [1182, 2958, 3399, 4192, 4836, 5657, 5872, 6023], 'vivo.': [1187, 2840], 'demonstrate': [1190], '4EBP-1': [1204, 4628, 4640, 4753], 'Antibodies': [1244], 'Reagents—Affinity-purified': [1246], 'antibody': [1247, 1273, 1281, 1320, 1373, 2275, 2696, 3053, 3385, 3392], 'against': [1248, 1282], 'GST': [1249, 1256, 2286, 2921, 3292, 3302], 'prepared': [1251, 3706, 4275], 'from': [1252, 1288, 1323, 1352, 1376, 1593, 1757, 1806, 2723, 2785, 2822, 4276, 4407], 'anti-GST': [1253, 2350, 3060], 'serum': [1254], 'using': [1255, 1888, 2187, 2261, 2268, 3107], 'immobilized': [1257, 2300], 'on': [1258, 2049, 2301, 2531, 2560, 3023, 3753, 3762, 3817, 4002, 4282, 4331, 5404], 'glutathione-Sepharose': [1259], 'affinity': [1262], 'matrix.': [1263], 'The': [1264, 1294, 1586, 1655, 1685, 1705, 1829, 1901, 2327, 2428, 2441, 2451, 2602, 2649, 4149, 5604, 5895], 'monoclonal': [1266, 1271, 1302, 1371], 'antibody,': [1268, 1299, 1306, 1310, 1315], 'phosphotyrosine': [1272], '(4G10),': [1274], 'rabbit': [1277, 1295, 1307, 1311, 1317, 1335, 1338, 1342, 1346], 'polyclonal': [1278, 1296, 1308, 1312, 1318, 1332, 1336, 1339, 1343, 1347], 'site-specific': [1280], 'Tyr-397': [1284], '(PY397)': [1285], 'were': [1286, 1321, 1351, 1374, 1709, 1754, 1766, 1803, 1822, 1833, 1847, 1860, 1870, 1880, 1895, 1918, 1976, 2010, 2045, 2051, 2075, 2171, 2192, 2220, 2259, 2297, 2329, 2422, 2434, 2465, 2484, 2518, 2529, 2547, 2565, 2604, 2630, 2651, 2691, 2758, 3048, 3380, 3683, 3704, 3799, 3820, 3955, 4263, 4274], 'obtained': [1287, 1322], 'Upstate': [1289], 'Biotechnology': [1290], '(Lake': [1291], 'Placid,': [1292], 'NY).': [1293], 'α-HA': [1297], '(Y11)': [1298], 'α-c-Myc': [1303], 'tag': [1304], '(9E10)': [1305], 'α-FAK': [1313], '(C20)': [1314], 'Santa': [1324], 'Cruz': [1325], 'Biotechnology,': [1326], 'Inc.': [1327, 1355], '(Santa': [1328], 'Cruz,': [1329], 'CA).': [1330], 'Rabbit': [1331], 'Thr-389': [1333], 'phospho-S6K,': [1334], 'S6,': [1337], 'Ser-240/244': [1340], 'phospho-S6,': [1341], 'Thr-37/46': [1348], 'phospho-4E-BP1': [1349], 'antibodies': [1350, 2229], 'Signaling': [1354], '(Beverly,': [1356], 'MA).': [1357, 1600], 'Anti-HA-conjugated': [1358], 'agarose': [1359, 2201], 'beads,': [1360, 1362], 'glutathione-agarose': [1361, 2204, 2302], 'A-Sepharose,': [1364], 'human': [1365], 'plasma': [1366], 'fibronectin': [1367], '(FN),': [1368], 'FLAG': [1372], 'purchased': [1375], 'Sigma.': [1377], 'Plasmid': [1378], 'DNA': [1379, 2361], 'Construction—HA-tagged': [1380], 'expression': [1381, 1396, 1401, 1884, 2426, 3499, 3804, 3960, 6063], 'vectors': [1382, 1454, 2928, 6064], 'pKH3,': [1383], 'pKH3-FAK,': [1384], 'pKH3-FAK-Y397F,': [1385], 'pKH3-FAK-kd': [1386], '(kinase': [1387, 1391, 3082, 3116], 'dead),': [1388], 'pKH3-NT-FAK,': [1389], 'pKH3-KD-FAK': [1390], 'domain),': [1392], 'pKH3-CT-FAK,': [1393], 'pKH3-KC-FAK,': [1394], 'Myc-tagged': [1395, 2677, 3171, 3362, 3364], 'pHAN,': [1398], 'pHAN-FAK,': [1399], 'GST-tagged': [1400, 2749, 2918, 3028], 'pDHGST,': [1403], 'pDHGST-FAK': [1405], 'described': [1408, 1472, 1614, 1780, 1922, 2373, 2656], '(35Cooper': [1410], 'L.A.': [1411, 4513, 5309], 'Shen': [1412, 1429], 'J.L.': [1415, 1436, 1624, 1930, 1963, 2403, 5584], '8030-8041Crossref': [1421], '(145)': [1424], '36Han': [1427], 'Miao': [1431], 'Wang': [1433], '277:': [1441, 1507], '45655-45661Abstract': [1442], '(68)': [1450], 'Expression': [1453], 'encoding': [1455, 1904, 2676, 2748, 2917, 2929, 3034, 3177, 3699, 3806, 3962], 'HA-TSC2,': [1456, 2932], 'HA-TSC2': [1457, 1459, 1461, 1463, 2713], '1–1320,': [1458], '1–1080,': [1460], '1–608,': [1462], '1080–1765,': [1464], 'GST-TSC2,': [1465], 'Myc-TSC1,': [1466], 'HA-S6K,': [1467], 'FLAG-4EBP-1': [1469], '37Li': [1495], 'Inoki': [1497, 5787], '44593-44596Abstract': [1508], '(98)': [1516], '609–1080-amino': [1520], 'acid': [1521], 'segment': [1522], 'amplified': [1524], 'primers': [1526], '5′-CCCATCGATTTAGGCCCCACGGGACACCTGCTGCCC-3′': [1527], '(forward)': [1528, 1691, 1701], '5′-CGCGGATCCAGCATCCGGCTGCAGGCCTTTGAC-3′': [1530], '(reverse),': [1531], 'digested': [1532, 1541, 1554, 1577, 1649], 'BamHI': [1534, 1565, 1579], 'EcoRI,': [1536], 'ligated': [1538, 1574], 'pKH3': [1540], 'same': [1544], 'enzymes': [1545], 'generate': [1547, 1583, 1683], 'pKH3-TSC2': [1548, 1550], '609–1080.': [1549, 1585], '609–1080': [1551, 1570, 2294, 3266, 3297, 3310], 'then': [1553, 1670, 2084, 2305, 2330, 2640, 2692, 3381, 3705, 3821, 3956, 3980, 4919], 'ClaI': [1556], 'filled': [1558], 'Klenow': [1561], 'enzyme': [1562], 'followed': [1563, 2240, 2698, 2763, 3054, 3188, 3386, 4290], 'digestion': [1566], 'release': [1568], 'segment,': [1571], 'into': [1575, 1645, 1672, 2686, 2760, 2924, 3375], 'pGEX2T': [1576], 'SmaI': [1581], 'pGEX2T-TSC2': [1584], 'RNAi': [1587, 1604, 1706, 1911, 1917, 1993, 1996, 3935, 3967, 4268, 6087], 'pBS-U6': [1589, 1647, 3937, 3969], 'gift': [1592, 1836], 'Shi': [1595, 6080], '(Harvard': [1596], 'Medical': [1597, 6083], 'School,': [1598], 'Boston,': [1599], 'Construction': [1601], 'achieved': [1607], 'separate': [1610], 'steps': [1611], '(38Gan': [1615], 'Melkoumian': [1617, 2396], 'Z.K.': [1618, 2397], 'X.': [1620, 1924, 1953, 2399, 4425, 5221], '170:': [1629, 2408], '379-389Crossref': [1630, 2409], '(77)': [1633, 2412], 'Briefly,': [1636, 2143, 2415], '22-nucleotide': [1638], 'oligo': [1639], '(oligo': [1640, 1667], '1)': [1641], 'first': [1643, 2672, 5331, 5884], 'inserted': [1644], 'ApaI': [1651], '(blunted)': [1652], 'HindIII.': [1654], 'inverted': [1656], 'motif': [1657], 'contained': [1659], '6-nucleotide': [1661], 'spacer': [1662], '5': [1664], 'T': [1665], 'residues': [1666], '2)': [1668], 'subcloned': [1671], 'HindIII': [1674], 'EcoRI': [1676], 'sites': [1677, 6029], 'intermediate': [1680], 'plasmid': [1681], 'pBS-U6-TSC2.': [1684], 'sequence': [1686, 1696, 1723], 'oligo1': [1688], '5′-GGCAGATTTGTGAAGTCGCAAA-3′': [1690], '5′-AGCTTTTGCGACTTCACAAATCTGCC-3′': [1693], '(reverse);': [1694], 'oligo2': [1698], '5′-AGCTTTTGCGACTTCACAAATCTGCCCTTTTTG-3′': [1700], '5′-AATTCAAAAAGGGCAGATTTGTGAAGTCGCAAA-3′': [1703], '(reverse).': [1704], 'targeting': [1707], 'sequences': [1708], 'all': [1710, 5541, 5845], 'analyzed': [1711, 2345, 2652, 3708], 'BLAST': [1713], 'search': [1714], 'ensure': [1716], 'they': [1718], 'did': [1719, 2971, 3206, 3728, 4370], 'significant': [1722, 4989], 'homology': [1724], 'genes.': [1727], 'Culture,': [1729], 'Transfection,': [1730], 'Adenovirus': [1732], 'Infection—The': [1733], 'TSC2–/–': [1734, 4037, 4079, 4577, 4582, 4617, 4643, 6066], 'LEF': [1735, 4038, 6067], 'cells': [1736, 1802, 1856, 1859, 1869, 2009, 2044, 2074, 2417, 2433, 2452, 2516, 2528, 2546, 2564, 2603, 2615, 2624, 2629, 2650, 2724, 2762, 2786, 2824, 2926, 3187, 3493, 3682, 3736, 3783, 3798, 3845, 3894, 3950, 3954, 4039, 4075, 4262, 4278, 4280, 4309, 4580, 4585, 4633, 4644, 4955, 5463, 6068], 'stably': [1738, 4041, 6070], 'express': [1739, 4042, 6071], 'either': [1740, 2933, 3971, 4043, 6072], '(TSC2–/–': [1742, 1750, 4045, 4053, 4606], '+': [1743, 1751, 4046, 4054, 4578, 4583, 4607], 'cells)': [1745, 1753, 4048], 'VEC': [1752, 4055, 4584], 'generous': [1755, 1804, 1835], 'gifts': [1756, 1805], 'Dr.': [1758, 1838, 6051, 6078, 6108], 'Kun-Liang': [1759, 6052], 'University': [1762, 6056, 6112], 'Michigan': [1764, 6058], 'maintained': [1767, 1823, 1848], 'DMEM': [1769, 1825, 1850, 1863, 1873], 'supplemented': [1770, 1851, 1864, 1874], '10%': [1772, 1827, 1853, 1866, 1876, 2103, 2492, 2644], 'FBS': [1773, 2645], 'containing': [1774, 2019, 2585, 3295], '0.5': [1775, 2024, 2128], 'mg/ml': [1776, 2025], 'G418,': [1777], '(18Inoki': [1781, 2374], '115:': [1789, 2382, 4459, 5255], '577-590Abstract': [1790, 2383, 4460, 5256], '(3034)': [1798, 2391, 4468, 5264], 'SYF': [1801, 3492, 6105], 'Drs.': [1807, 6090], 'Cary,': [1809, 6092], 'Klinghoffer,': [1811, 6094], 'Soriano': [1814, 3514, 6097], 'Fred': [1816, 6099], 'Hutchinson': [1817, 6100], 'Research': [1819, 6102], 'Center': [1820, 6103], 'FBS.': [1828, 1854, 1867, 2526], 'KO': [1831, 3908, 6119], 'MEFs': [1832, 3909, 3913], 'Ilic': [1840, 6110], '(University': [1841], 'California,': [1843, 6114], 'San': [1844, 6115], 'Franscisco)': [1845], '293T': [1855, 2416, 2687, 2761, 2925, 3045, 3186, 3376, 3681, 3782, 3797, 3893, 3949, 3953, 4759], 'HeLa': [1858, 4261], 'cultured': [1861, 1871, 2442, 2641], 'NIH3T3': [1868, 2809], 'calf': [1877], 'serum.': [1878], 'Cells': [1879, 1975, 2047, 2483], 'transfected': [1881, 2423, 3801, 3957], 'plasmids': [1885], 'indicated': [1887, 2231, 3880, 5813], 'Lipofectamine™': [1889], 'following': [1890, 4884], "manufacturer's": [1892], 'instructions.': [1893], 'Experiments': [1894], 'conducted': [1896], '24–48': [1897], 'h': [1898, 1985, 1999, 2210, 2236, 2246, 2324, 2448], 'after': [1899, 2458], 'transfection.': [1900], 'recombinant': [1902, 2308, 3283, 3291], 'adenoviruses': [1903, 1912, 4266], '(Ad-FAK': [1909], 'kd),': [1910, 3370], 'Ad-FAK': [1913, 1979, 1992, 4267], 'Ad-Control': [1916, 1995, 4270], '(39Wu': [1923], 'Gan': [1925], 'Yoo': [1927], 'Dev.': [1931, 4520, 5316], '9:': [1934], '185-196Abstract': [1935], '(149)': [1943], '40Shen': [1946], 'Park': [1948], 'A.Y.': [1949], 'Alcaraz': [1950], 'Peng': [1952], 'Jang': [1954], 'I.': [1955], 'Koni': [1956], 'Flavell': [1958], 'R.A.': [1959, 3509], 'Gu': [1960], '169:': [1968], '941-952Crossref': [1969], '(248)': [1972], 'infected': [1977, 1990, 4264], 'kd': [1980, 3081, 3408, 3428, 3442, 3455, 3690, 3743, 3772, 3808, 3842, 3964, 3990, 4007, 4032, 4064, 4745, 4947], 'Ad-GFP': [1982], '36': [1984], 'before': [1986, 2000, 2163, 2558], 'experiments': [1988, 2072, 2120, 3105], '72': [1998], 'experiments.': [2002], 'For': [2003, 2119, 2622, 5440, 5647], 'FN': [2004, 2050, 2059], 'replating': [2005], 'experiment,': [2006], 'growing': [2008], 'briefly': [2011], 'trypsinized,': [2012], 'resuspended': [2013, 2519, 2579], 'medium': [2018, 2443], 'final': [2021, 2515], 'concentration': [2022, 2184], 'soybean': [2026], 'trypsin': [2027], 'inhibitor,': [2028, 5451], 'washed': [2029, 2076, 2331, 2466, 2507, 2573], 'twice': [2030, 2077], 'medium,': [2035], 'held': [2037], 'suspension': [2039, 4336, 4366, 4594, 4624], '60': [2041], 'min.': [2042, 2601], 'Indicated': [2043], 'lysed.': [2046], 'replated': [2048, 4281], 'added': [2052], 'plates': [2054, 2421, 2464], 'coated': [2055], '10': [2057, 2112, 2176], 'μg/ml': [2058, 2113, 2117, 2591], 'different': [2061, 4285], 'periods': [2062, 4286], 'time': [2064, 2554, 4288, 5332], 'indicated.': [2066], 'Immunoprecipitation': [2067], 'Western': [2069, 2263, 2347, 2700, 3056, 3388, 3710, 4292], 'Blotting—For': [2070], 'most': [2071, 5400], 'subconfluent': [2073], 'ice-cold': [2079], 'saline': [2081], '(PBS)': [2082], 'lysed': [2085], '1%': [2087, 2100, 2315, 2511, 2525, 2577], 'Nonidet': [2088, 2101, 2316], 'P-40': [2089, 2317], 'lysis': [2090, 2134, 2166, 2255, 2318, 2335], 'buffer': [2091, 2135, 2167, 2319], '(20': [2092], 'mm': [2093, 2098, 2106, 2109, 2129, 2145, 2152], 'Tris,': [2094], 'pH': [2095], '8.0,': [2096], '137': [2097], 'NaCl,': [2099], 'P40,': [2102], 'glycerol,': [2104], 'Na3VO4,': [2107], 'phenylmethylsulfonyl': [2110], 'fluoride,': [2111], 'aprotinin,': [2114], '2': [2116, 2476], 'leupeptin).': [2118], 'detect': [2122, 2215, 2733, 2800], 'TSC2,': [2127, 2670, 3123, 3229, 3938, 3970, 4028, 4926], 'pervanadate': [2130], 'instead': [2136], 'sodium': [2138, 2146], 'vanadate': [2139, 2147], 'phosphatase': [2141], 'inhibitor.': [2142], '500': [2144, 2151], 'mixed': [2149], 'H2O2': [2153], '(1:1)': [2154], 'incubated': [2156, 2306, 2471, 2595], 'at': [2157, 2178, 2211, 2237, 2325, 2472, 2503, 2549, 2567, 2596, 2636, 5907], 'room': [2158], 'temperature': [2159], '10–15': [2161], 'min': [2162, 2177, 2477, 2502], 'adding': [2164, 2534], '(1:250': [2168], 'dilution).': [2169], 'Lysates': [2170], 'cleared': [2172], 'centrifugation': [2174], '4': [2179, 2212, 2238, 2550], '°C,': [2180], 'total': [2182], 'determined': [2186], 'Bio-Rad': [2188], 'assay.': [2190], 'Immunoprecipitations': [2191, 3047], 'carried': [2193, 2221, 2266], 'out': [2194, 2222, 2267], 'incubating': [2196, 2224], 'lysates': [2198, 2226, 2690, 2722, 2784, 3379, 3703, 4273], 'HA-conjugated': [2200], 'beads': [2202, 2205, 2303], 'more': [2207, 2233, 2321], 'than': [2208, 2234, 2322], '3': [2209, 2235, 2245, 2323, 2501, 2535, 2571, 4016], '°C.': [2213], 'To': [2214, 2461, 3345, 3677, 3786, 3919, 4019], 'endogenous': [2216, 2804, 3467, 3944, 4069, 4255], 'protein-protein': [2217], 'interaction,': [2218, 5982], 'immunoprecipitations': [2219, 3190], 'appropriate': [2228], '°C': [2239, 2474, 2551, 2598], 'incubation': [2242], 'another': [2244, 3777], 'A-Sepharose.': [2249], 'After': [2250], 'washing': [2251], '3–5': [2252], 'times': [2253, 2333], 'buffer,': [2256, 2336, 2340], 'immune': [2257], 'complexes': [2258], 'resolved': [2260, 2341], 'SDS-PAGE.': [2262], 'blotting': [2264, 2348, 2701, 3057, 3389, 3711, 4293], 'horseradish': [2269], 'peroxidase-conjugated': [2270], 'IgG': [2271], 'secondary': [2274], 'Amersham': [2278], 'Biosciences': [2279], 'ECL': [2280], 'system': [2281], 'detection.': [2283], 'Preparation': [2284], 'Fusion': [2287], 'Proteins': [2288], 'Vitro': [2291], 'Binding': [2292, 3012], 'Assays—GST-TSC2': [2293], 'fusion': [2295, 3293], 'purified': [2298], 'His-tagged': [2309, 3282], '300': [2312], 'μl': [2313], '4°C.': [2326], 'samples': [2328], 'five': [2332], 'boiled': [2337], 'SDS': [2339], 'SDS-PAGE,': [2343], 'anti-FAK': [2352], 'antibody.': [2353, 2704, 2768, 3061], 'Size': [2355, 3549], 'Assay—To': [2356], 'determine': [2357, 2613, 3018, 3346, 3716, 3920], 'content,': [2362], 'FACS': [2363, 2610, 2654], 'analysis': [2364, 2559, 2611], 'Quest': [2367], 'software': [2368], 'performed': [2370, 3049], '38Gan': [2394], 'grown': [2418], '60-mm': [2420], 'vectors.': [2427], 'next': [2429], 'day': [2430], 'confluent': [2432, 2455], 'split': [2435], '10-cm': [2437, 2634], 'dishes': [2438], '(1:4': [2439], 'split).': [2440], 'changed': [2445], 'every': [2446], '24': [2447], 'until': [2449, 2552], 'confluent.': [2450], 'usually': [2453], 'became': [2454], 'harvest': [2457, 2462], '2–3': [2459], 'days.': [2460], 'cells,': [2463, 3860, 4888, 6106], 'once': [2467, 2508, 2574], 'PBS': [2469, 2584], '37': [2473, 2597], 'ml': [2480, 2522, 2536, 2582], 'trypsin-EDTA.': [2482], 'gently': [2485], 'pipetted': [2486], 'off': [2487], 'plate': [2489], 'transferred': [2494], '15-ml': [2496], 'conical': [2497], 'tubes,': [2498], 'centrifuged': [2499, 2566], '1000': [2504], 'rpm,': [2505], 'pellets': [2517], 'Resuspended': [2527], 'fixed': [2530, 2563], 'ice': [2532], 'cold': [2538], '100%': [2539], 'ethanol': [2540], '(75%': [2541], 'final)': [2542], 'while': [2543], 'vortexing.': [2544], 'Fixed': [2545], 'stored': [2548], 'analysis.': [2556], 'Immediately': [2557], '1500': [2568], 'rpm': [2569], 'min,': [2572], '0.1%': [2586], 'Triton': [2587], 'X-100': [2588], '100': [2590], 'RNase': [2592], 'A,': [2593], '20–30': [2600], 'stained': [2605], 'propidium': [2607], 'iodide': [2608], 'G1-phase': [2618], 'G2/M-phase': [2620], 'populations.': [2621], 'MEF': [2623], 'analysis,': [2626], 'completely': [2627], 'trypsinized': [2628], 'seeded': [2631], 'dish': [2635], '20%': [2637], 'confluency': [2638], '90%': [2647], 'confluency.': [2648], 'above.': [2657], 'Association': [2658], 'TSC2—To': [2662, 3017], 'investigate': [2663, 3787], 'co-transfected': [2673, 2725, 2759, 2787, 2915, 3357, 3684], 'HA-tagged': [2680, 2752, 3035, 3179, 3358, 3686, 3700], 'HA': [2683, 2727, 2755, 2789], 'cells.': [2688, 2810, 2828, 3046, 3377, 3875, 4080, 4314, 4618, 4760], 'immunoprecipitated': [2693, 3382], 'anti-HA': [2695, 2767, 3052, 3192, 3384], 'anti-Myc': [2703], 'Fig.': [2705, 2744, 2814, 2938, 3062, 3197, 3452, 3835, 3982, 4057, 4082, 4296, 4340, 4589], '1A': [2706], 'shows': [2707, 2940, 3064, 3837, 3984, 4059, 4084, 4298, 4342, 4591], 'Myc-FAK': [2709], 'co-immunoprecipitated': [2711, 3070, 3076], 'but': [2714, 2776, 2825, 3300, 3404, 4076, 4097, 4634], 'detected': [2716, 2778, 2818, 2959], 'immunoprecipitates': [2719, 2737, 2781, 2821, 2962], 'control': [2721, 2783, 4312], 'vector.': [2729, 2791], 'reciprocal': [2739], 'IP.': [2740], 'As': [2741, 2811, 3194], '1B,': [2745], 'immunoprecipitation': [2765], 'GST-TSC2': [2769], 'found': [2771, 3280, 3721, 3767, 3902, 4621], 'co-immunoprecipitate': [2773], 'HA-FAK': [2775], 'Consistent': [2792, 3758, 3897], 'transfection': [2795], 'studies,': [2796], '1C,': [2815], 'anti-TSC2': [2820], 'attached': [2823], 'suspended': [2827, 4277, 4887], 'interact': [2836, 2911, 2974, 3209, 3217, 4104], 'It': [2841, 4970, 5505, 6021], 'stable': [2851], 'Thus,': [2904, 3261, 3665], 'tested': [2906], 'whether': [2907, 3347, 3788, 3921, 4166, 4318, 5082], 'TSC1.': [2913], 'Myc-TSC1': [2930], 'individually': [2934, 3972], 'combination.': [2937], '1D': [2939], 'coimmunoprecipitate': [2944], 'regardless': [2947], 'co-expression': [2950, 2979, 3169], '(lanes': [2951], '3).': [2954], 'when': [2963], 'co-expressed': [2966, 3026], '(lane': [2967, 2980], '1).': [2968], 'apparently': [2973, 3208], 'without': [2977], '2).': [2981], 'These': [2982, 3141], 'ternary': [2990], 'indirectly': [3000], 'interacts': [3001], 'association': [3006, 3100, 4845], 'Characterization': [3009], 'Regions': [3013], 'site': [3022], 'wild-type': [3036, 3687, 3726], 'mutants': [3041, 3111, 3182], '(Fig.': [3042, 3136, 3183, 3256, 3306, 3422, 3438, 3526, 3756, 3784, 3895, 3914, 3951, 4645], '2A)': [3043], '2C': [3063], 'that,': [3065, 3722, 3985], 'expected,': [3067], 'HA-FAK.': [3072], 'Y397F': [3079], 'dead)': [3083], 'mutants,': [3084], 'suggesting': [3085, 3230, 3308, 3410, 3528, 3632, 4862, 4997, 5983], 'neither': [3087, 3237, 5974], '397': [3089], 'nor': [3091, 3239, 5977], 'activity': [3093, 6014], 'Further': [3103], 'mapping': [3104], 'several': [3108, 4408, 4724, 5106], 'truncation': [3110, 3181], 'demonstrated': [3112], 'KD': [3115, 4089, 4848], 'domain)': [3117], 'KC': [3119], 'associated': [3121], 'NT': [3126, 4099, 4850], 'CT': [3129], 'showed': [3131, 3195, 3250, 4188, 5328], '2,': [3137, 3257], 'A': [3138, 3155, 5119], 'C).': [3140], 'mediates': [3150, 3315], 'similar': [3156], 'strategy': [3157], 'define': [3161], 'region': [3165], 'within': [3166], '2B)': [3184], 'antibodies.': [3193], '2D,': [3198], '1081–1765': [3200], 'fragment,': [3201], 'Rheb-GAP': [3204, 3232], 'domain,': [3205], '1–1080': [3214], 'fragment': [3215, 3227, 3249], 'well': [3221], 'full-length': [3223], '1–1320': [3226], 'sufficient': [3238, 3287], '1–608': [3248], 'obvious': [3252], 'B': [3258], 'D).': [3260], 'amino': [3267, 3298, 3311], 'acids': [3268, 3312], 'Last,': [3278], 'bind': [3289], 'acids,': [3299], 'alone,': [3303], 'vitro': [3305], '2E),': [3307], 'direct': [3317], 'TSC2—The': [3326], 'identification': [3327], 'raises': [3335], 'possibility': [3337], 'serves': [3349, 3413], 'substrate': [3353, 3417], '(FAK': [3369], 'Myc': [3372], 'anti-phosphotyrosine': [3391], '4G10.': [3393], 'observed': [3395, 3490], 'WT': [3402, 3450, 3912, 4322], 'mutant,': [3409, 3691], '3A).': [3423, 3439], 'Interestingly,': [3424, 3616, 4356], 'even': [3430], 'decreased': [3431, 3475, 3744, 3773, 3903, 3991], 'basal': [3433, 3477], 'level': [3435, 3479, 3947, 5692], 'Because': [3440], 'interacted': [3443], 'efficiently': [3447], '(see': [3451], '2B),': [3453], 'dominant': [3461, 3750, 4110], 'compete': [3465], 'and,': [3473], 'thus,': [3474, 4244, 4572, 4777], 'deficient': [3496], 'Src': [3501, 3539], 'family': [3502, 3540], 'Src,': [3504], 'Yes,': [3505], 'Fyn': [3507], '(26Klinghoffer': [3508], 'Sachsenmaier': [3510], 'C.': [3511], 'Cooper': [3512], 'J.A.': [3513], 'EMBO': [3516], '18:': [3519, 4522, 5318], '2459-2471Crossref': [3520], '(647)': [3523], 'Scholar)': [3525, 5194], '3B),': [3527], 'independent': [3536], 'kinases.': [3541], 'Regulation': [3543, 4157], 'TSC2—Recent': [3551], 'mTOR-S6K': [3565], 'pathway': [3566], 'it': [3617, 3666, 4369, 5078, 5442, 5649, 5999], 'FAK-related': [3624, 4985], 'non-kinase': [3625, 4986], 'inhibited': [3626], 'possible': [3668, 5507], 'examine': [3678], 'possibility,': [3680], 'along': [3695], 'S6K.': [3701], 'anti-Thr-389-phosphorylated': [3713], 'state.': [3719], 'significantly': [3730, 3941], 'affect': [3731, 4372], '(data': [3737], 'shown),': [3739], 'consistent': [3747, 5098], 'effect': [3752, 4001, 4247, 4330, 4612], '4A).': [3757], 'result': [3761], '4B).': [3785], 'any': [3791, 4169, 4329, 5087], 'control,': [3796, 3813], 'transiently': [3800], 'effects': [3816], 'measured': [3822], 'determining': [3824], 'scatter': [3828], '(mean': [3829], 'FSC-H)': [3830], 'flow': [3833], 'cytometer.': [3834], '4C': [3836], 'led': [3846], 'left-shift': [3849], 'FSC-H': [3853], 'distribution': [3854], 'compared': [3855, 3910, 4310, 4573], 'vector-transfected': [3859], 'corresponds': [3862], 'decrease': [3865, 3883, 4599, 4637, 4963], 'kd-transfected': [3872, 3892], 'populations': [3873], 'Quantification': [3876], '∼5%': [3882], 'average': [3886], '4D).': [3896], 'this,': [3899], '4,': [3915], 'E': [3916], 'F).': [3918], 'not,': [3931], 'generated': [3933], 'down-regulate': [3942], '5A).': [3952], 'combination,': [3975], 'tested.': [3981], '5A': [3983], '(compare': [3994, 4014], 'lanes': [3995, 4015], '2),': [3998], 'abolished': [4009, 4615, 4768], 'under': [4010, 4334, 4365], 'knock-down': [4012, 4257, 4771, 5979], 'condition': [4013], '4).': [4018], 'test': [4021], 'relationship': [4024], 'overexpressed': [4030], 'via': [4033], 'adenoviral': [4034], 'infection': [4035], 'cells).': [4056], '5B': [4058], 'caused': [4065, 4596, 4987], 'reduction': [4067, 4990], 'reexpressing': [4074, 4605, 4632], '5C': [4083], '(which': [4090, 4101], 'interacting': [4094], 'TSC2),': [4096, 4106], 'does': [4102], 'functioned': [4107], 'suppress': [4114, 4903], 'phosphorylation.': [4116, 4355, 4393], 'Collectively,': [4117], 'upstream': [4124, 4783], 'up-regulates': [4134], 'potentially': [4140], 'Roles': [4150], 'Adhesion—We': [4163], 'examined': [4165, 4245, 4317], 'physiological': [4170], 'potently': [4193], 'activated': [4194, 4917], 'adhesion,': [4197], 'promote': [4201], '25Malik': [4223], 'We,': [4243, 4571], 'upon': [4254, 4586, 4967], 'RNAi.': [4260, 4271], 'fibronectins': [4283], 'phospho-S6K.': [4295], '6A': [4297], 'attenuated': [4305], 'RNAi-treated': [4308, 4313], 'would': [4327, 6022], 'conditions.': [4339], '6B': [4341], 'suppressed': [4350], 'wild': [4360], 'type': [4361], 'increased': [4362, 4930], 'conditions,': [4367], 'during': [4375], 'Taken': [4378, 4877], 'together,': [4379, 4878], 'integration': [4402], 'point': [4403], 'receive': [4405], 'stimuli,': [4409], 'such': [4410, 5061, 5204], 'factors,': [4413, 5207], 'nutrients,': [4414], 'intracellular': [4415, 5202], 'energy': [4416, 5208, 5691], 'levels,': [4417], 'hypoxia,': [4419], '(11Gao': [4424, 5220], 'Zhang': [4426, 5222, 5581], 'Arrazola': [4428, 5224], 'Hino': [4430, 5226, 5568], 'O.': [4431, 5227, 5563, 5569], 'Kobayashi': [4432, 5228], 'Ru': [4436, 5232], 'Pan': [4438, 5234], '699-704Crossref': [4445, 5241], '(577)': [4448, 5244], '18Inoki': [4451, 5247], '27Zhang': [4471, 5267], 'Cicchetti': [4473, 5269], 'Onda': [4475, 5271, 5591], 'Koon': [4477, 5273], 'H.B.': [4478, 5274], 'Asrican': [4479, 5275], 'Bajraszewski': [4481, 5277], 'N.': [4482, 5278, 5491, 5590], 'Vazquez': [4483, 5279], 'F.': [4484, 5280], 'Carpenter': [4485, 5281], 'C.L.': [4486, 5282], 'Kwiatkowski': [4487, 5283], 'Clin.': [4490, 5286], 'Investig.': [4491, 5287], '112:': [4493, 5289], '1223-1233Crossref': [4494, 5290], '28Brugarolas': [4500, 5296], 'Lei': [4502, 5298], 'Hurley': [4504, 5300], 'R.L.': [4505, 5301], 'Manning': [4506, 5302], 'Reiling': [4508, 5304], 'J.H.': [4509, 5305], 'Hafen': [4510, 5306], 'Witters': [4512, 5308], 'Ellisen': [4514, 5310], 'L.W.': [4515, 5311], 'Kaelin': [4516, 5312], 'Jr.,': [4517, 5313], 'W.G.': [4518, 5314], 'Genes': [4519, 5315], '2893-2904Crossref': [4523, 5319], '(1078)': [4526, 5322], 'addressed.': [4544], 'Our': [4545, 4775, 5093, 5325], 'observation': [4546, 5102], 'suggests': [4558, 4779], 'inactivation': [4567], 'suspension.': [4570, 4588, 4969], '6C': [4590], 'treatment': [4595], 'dramatic': [4598], 'TSC2)': [4608], 'cells;': [4609], 'however,': [4610], 'largely': [4614], 'Similarly,': [4619], 'down-regulated': [4625], 'failed': [4635], '6C).': [4646], 'strongly': [4650, 4778], 'mediator': [4667], 'transduction': [4670], 'pathways': [4671, 5414], 'initiated': [4672], 'integrins': [4674], 'cycle': [4681], 'lines': [4725], 'First,': [4741], 'decreases': [4755], 'Second,': [4761], 'knock-out': [4773], 'background.': [4774], 'study,': [4776], 'addition,': [4796], 'adhesion-dependent': [4825], 'Importantly,': [4840], 'domains': [4851], 'correlated': [4854], 'ability': [4857], 'possibly': [4868], 'together': [4881], 'model.': [4885], 'because': [4889, 5045], 'inactivated,': [4892], 'FAK-mediated': [4893, 5083, 6040], 'relieved,': [4898], 'activates': [4911], 'promotes': [4914], 'FAK-TSC2': [4915], 'interaction;': [4916], 'inactivates': [4920], 'lead': [4928], 'This': [4936, 5881], 'model': [4937], 'explains': [4939], 'findings': [4941], 'adhered': [4954], 'integrin-mediated': [4975, 4993], 'stimulated': [4978], 'addressed': [5040], 'study.': [5043, 6046], 'Scholar),': [5077, 5844], 'clear': [5081, 5784, 5906], 'presented': [5095], 'here': [5096, 5327], 'previous': [5101], 'provides': [5105], 'mechanistic': [5108], 'insights': [5109], '4E-BP1': [5145], 'variety': [5198], 'signals': [5203], 'level,': [5209, 5211], 'nutrient': [5210], 'hypoxia': [5213], 'Integrin-mediated': [5350], 'angiogenesis': [5369, 5436, 5450, 5514], 'focused': [5403], 'integrin-regulated': [5408], 'migration': [5413], 'angiogenesis,': [5416], 'begun': [5420], 'reveal': [5422], 'example,': [5441, 5648], 'tumstatin,': [5447], 'specifically': [5452], 'cap-dependent': [5457], 'vascular': [5461, 5546], 'endothelial': [5462], 'tumstatin': [5465, 5477], 'αVβ3,': [5469], 'mediate': [5472], 'anti-angiogenic': [5474], '(29Maeshima': [5478], 'Sudhakar': [5480], 'Lively': [5482], 'J.C.': [5483], 'Ueki': [5484], 'Kharbanda': [5486], 'Kahn': [5488], 'C.R.': [5489], 'Sonenberg': [5490], 'Hynes': [5492], 'Kalluri': [5494], '295:': [5498], '140-143Crossref': [5499], '(397)': [5502], 'dysregulation': [5510], 'pathobiology': [5520], 'sclerosis.': [5523], 'Intriguingly,': [5524], 'TSC': [5525, 5612, 5645, 5688], 'patients': [5526], 'develop': [5527, 5538], 'cutaneous': [5528], 'angiofibromas': [5529], 'renal': [5531], 'angiomyolipomas,': [5532], 'TSC1,': [5534, 6061], 'heterozygous': [5536], 'mice': [5537], 'liver': [5539], 'hemangiomas,': [5540], 'highly': [5545], '30Kobayashi': [5560], 'Minowa': [5562], 'Kuno': [5564], 'Mitani': [5566], 'Noda': [5570], '59:': [5575], '1206-1211PubMed': [5576], '33Kwiatkowski': [5579], 'Bandura': [5583], 'Heiberger': [5585], 'K.M.': [5586], 'Glogauer': [5587], 'el-Hashemite': [5589], '11:': [5597], '525-534Crossref': [5598], '(541)': [5601], 'molecular': [5605, 5896], 'extensively': [5624], 'studied': [5625], 'recently.': [5626], 'Most': [5627], 'function.': [5646], 'kinase-mediated': [5680], 'deprivation': [5693], 'anisomycin-induced': [5765], 'mediated': [5769], 'MK2,': [5774], 'significance': [5778, 6038], '(34Li': [5785], 'Vacratsis': [5789], '278:': [5797], '13663-13671Abstract': [5798], '(138)': [5806], 'initial': [5811], 'far': [5851], 'kinases,': [5854], 'kinase(s)': [5858], 'unknown.': [5865], 'phosphorylate': [5893], 'present.': [5908], 'Previous': [5909], 'suggested': [5911], 'find': [5972], 'affects': [5980], 'formation.': [5997], 'Currently': [5998], 'tempting': [6001], 'speculate': [6003], 'toward': [6015], 'Rheb,': [6016], 'thus': [6017], 'promoting': [6018], 'activation.': [6020], 'interesting': [6024], 'future': [6045], 'grateful': [6049], 'vector,': [6077], 'Yang': [6079], 'Harvard': [6082], 'School': [6084], 'pBS-U6,': [6089], 'Franscisco': [6116], 'MEFs.': [6120], 'thank': [6122], 'colleagues': [6124], 'Peng,': [6126], 'Zara': [6127], 'Melkoumian,': [6128], 'Xiaoyang': [6129], 'Wu,': [6130], 'Dan': [6131], 'Rhoads,': [6132], 'Huei': [6134], 'Jin': [6135], 'Ho': [6136], 'reading': [6139], 'manuscript': [6142], 'helpful': [6144], 'comments.': [6145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056351159', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T17:42:09.256142', 'created_date': '2016-06-24'}