Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2056273145', 'doi': 'https://doi.org/10.1093/cvr/cvp301', 'title': 'A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo', 'display_name': 'A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo', 'publication_year': 2009, 'publication_date': '2009-08-28', 'ids': {'openalex': 'https://openalex.org/W2056273145', 'doi': 'https://doi.org/10.1093/cvr/cvp301', 'mag': '2056273145', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19717402'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/cvr/cvp301', 'pdf_url': 'https://academic.oup.com/cardiovascres/article-pdf/85/3/542/780194/cvp301.pdf', 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/cardiovascres/article-pdf/85/3/542/780194/cvp301.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075585589', 'display_name': 'Florian Krötz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'F. Krotz', 'raw_affiliation_strings': ['Cardiology Division, Medizinische Poliklinik, Ludwigs-Maximilians-Universität, Ziemssenstr. 1, Munich 80336, Germany', 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}, {'raw_affiliation_string': 'Cardiology Division, Medizinische Poliklinik, Ludwigs-Maximilians-Universität, Ziemssenstr. 1, Munich 80336, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043675737', 'display_name': 'Nicole Hellwig', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'N. Hellwig', 'raw_affiliation_strings': ['Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070965243', 'display_name': 'Martina Bürkle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'M. A. Burkle', 'raw_affiliation_strings': ['Medizinische Poliklinik - Innenstadt, the Institute of Anesthesiology, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Poliklinik - Innenstadt, the Institute of Anesthesiology, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064474716', 'display_name': 'Sherwin S. Lehrer', 'orcid': 'https://orcid.org/0000-0002-0284-4472'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'S. Lehrer', 'raw_affiliation_strings': ['Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015539893', 'display_name': 'Tobias Riexinger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'T. Riexinger', 'raw_affiliation_strings': ['Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046908944', 'display_name': 'Hanna Mannell', 'orcid': 'https://orcid.org/0009-0007-3190-356X'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'H. Mannell', 'raw_affiliation_strings': ['Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042270926', 'display_name': 'Hae‐Young Sohn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'H.-Y. Sohn', 'raw_affiliation_strings': ['Cardiology Division, Medizinische Poliklinik, Ludwigs-Maximilians-Universität, Ziemssenstr. 1, Munich 80336, Germany'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Division, Medizinische Poliklinik, Ludwigs-Maximilians-Universität, Ziemssenstr. 1, Munich 80336, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041502706', 'display_name': 'Volker Klauß', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'V. Klauss', 'raw_affiliation_strings': ['Cardiology Division, Medizinische Poliklinik, Ludwigs-Maximilians-Universität, Ziemssenstr. 1, Munich 80336, Germany'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Division, Medizinische Poliklinik, Ludwigs-Maximilians-Universität, Ziemssenstr. 1, Munich 80336, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070560020', 'display_name': 'Ulrich Pohl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'U. Pohl', 'raw_affiliation_strings': ['Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Walter-Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5075585589'], 'corresponding_institution_ids': ['https://openalex.org/I8204097'], 'apc_list': {'value': 4177, 'currency': 'EUR', 'value_usd': 4504, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.935, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.792721, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '85', 'issue': '3', 'first_page': '542', 'last_page': '550'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Management of Primary Aldosteronism', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperpolarization', 'display_name': 'Hyperpolarization (physics)', 'score': 0.56069314}, {'id': 'https://openalex.org/keywords/endothelial-dysfunction', 'display_name': 'Endothelial Dysfunction', 'score': 0.500202}, {'id': 'https://openalex.org/keywords/cremaster-muscle', 'display_name': 'Cremaster muscle', 'score': 0.42149347}], 'concepts': [{'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.75023675}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.5865631}, {'id': 'https://openalex.org/C131453863', 'wikidata': 'https://www.wikidata.org/wiki/Q1641079', 'display_name': 'Hyperpolarization (physics)', 'level': 3, 'score': 0.56069314}, {'id': 'https://openalex.org/C2776992346', 'wikidata': 'https://www.wikidata.org/wiki/Q111140', 'display_name': 'Endothelium', 'level': 2, 'score': 0.5378489}, {'id': 'https://openalex.org/C2777411675', 'wikidata': 'https://www.wikidata.org/wiki/Q1232438', 'display_name': 'Umbilical vein', 'level': 3, 'score': 0.53291607}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49394494}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4354084}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.42978764}, {'id': 'https://openalex.org/C2776354463', 'wikidata': 'https://www.wikidata.org/wiki/Q1724194', 'display_name': 'Cremaster muscle', 'level': 3, 'score': 0.42149347}, {'id': 'https://openalex.org/C3018697912', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Platelet activation', 'level': 3, 'score': 0.4194143}, {'id': 'https://openalex.org/C83743174', 'wikidata': 'https://www.wikidata.org/wiki/Q423778', 'display_name': 'Potassium channel', 'level': 2, 'score': 0.41865396}, {'id': 'https://openalex.org/C12722491', 'wikidata': 'https://www.wikidata.org/wiki/Q1632335', 'display_name': 'Microcirculation', 'level': 2, 'score': 0.412349}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.404558}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.309205}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.30161268}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29905483}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27822638}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2681867}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.25957757}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1757217}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C66974803', 'wikidata': 'https://www.wikidata.org/wiki/Q10359898', 'display_name': 'Nuclear magnetic resonance spectroscopy', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001685', 'descriptor_name': 'Biological Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013426', 'descriptor_name': 'Sulfaphenazole', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015126', 'descriptor_name': '8,11,14-Eicosatrienoic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015126', 'descriptor_name': '8,11,14-Eicosatrienoic Acid', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D015126', 'descriptor_name': '8,11,14-Eicosatrienoic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D001685', 'descriptor_name': 'Biological Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065729', 'descriptor_name': 'Cytochrome P-450 CYP2C9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008833', 'descriptor_name': 'Microcirculation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008833', 'descriptor_name': 'Microcirculation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010973', 'descriptor_name': 'Platelet Adhesiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024681', 'descriptor_name': 'Potassium Channels, Calcium-Activated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024681', 'descriptor_name': 'Potassium Channels, Calcium-Activated', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013426', 'descriptor_name': 'Sulfaphenazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/cvr/cvp301', 'pdf_url': 'https://academic.oup.com/cardiovascres/article-pdf/85/3/542/780194/cvp301.pdf', 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19717402', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/cvr/cvp301', 'pdf_url': 'https://academic.oup.com/cardiovascres/article-pdf/85/3/542/780194/cvp301.pdf', 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1540295714', 'https://openalex.org/W1619653867', 'https://openalex.org/W1965697927', 'https://openalex.org/W1979258550', 'https://openalex.org/W1980975971', 'https://openalex.org/W1993452291', 'https://openalex.org/W2000860252', 'https://openalex.org/W2011680378', 'https://openalex.org/W2032019404', 'https://openalex.org/W2037527379', 'https://openalex.org/W2041001842', 'https://openalex.org/W2042101459', 'https://openalex.org/W2046921348', 'https://openalex.org/W2056445732', 'https://openalex.org/W2059052527', 'https://openalex.org/W2064489455', 'https://openalex.org/W2072190804', 'https://openalex.org/W2080232758', 'https://openalex.org/W2084158921', 'https://openalex.org/W2086773515', 'https://openalex.org/W2093977379', 'https://openalex.org/W2097040145', 'https://openalex.org/W2102447197', 'https://openalex.org/W2115475125', 'https://openalex.org/W2116763228', 'https://openalex.org/W2117061040', 'https://openalex.org/W2118584840', 'https://openalex.org/W2126730931', 'https://openalex.org/W2133501311', 'https://openalex.org/W2146430060', 'https://openalex.org/W2148959908', 'https://openalex.org/W2149991029', 'https://openalex.org/W2153470962', 'https://openalex.org/W2153819503', 'https://openalex.org/W2157959829', 'https://openalex.org/W2161953383', 'https://openalex.org/W2166936192', 'https://openalex.org/W2172030847', 'https://openalex.org/W2216083099', 'https://openalex.org/W2326417371', 'https://openalex.org/W2996998526'], 'related_works': ['https://openalex.org/W2405977168', 'https://openalex.org/W2396218635', 'https://openalex.org/W2138208164', 'https://openalex.org/W2058526712', 'https://openalex.org/W2037008180', 'https://openalex.org/W2035761112', 'https://openalex.org/W2005348832', 'https://openalex.org/W1940255321', 'https://openalex.org/W1521054430', 'https://openalex.org/W143442218'], 'abstract_inverted_index': {'A': [0], 'CYP2C9-dependent': [1], 'endothelium-derived': [2], 'hyperpolarizing': [3], 'factor': [4, 89, 192], '(EDHF)': [5], 'controls': [6], 'blood': [7], 'flow': [8], 'in': [9, 40, 60, 85, 162, 182, 208, 255], 'many': [10], 'microvascular': [11], 'beds': [12], 'of': [13, 43, 63, 70, 103, 115, 133, 137, 148, 152, 159, 197, 202, 222, 226, 231, 248, 252], 'various': [14], 'species': [15], 'by': [16, 57, 166, 220], 'targeting': [17], 'vascular': [18], 'smooth': [19], 'muscle': [20, 62], 'potassium': [21, 189], 'channels.': [22, 190], 'Since': [23], 'platelets': [24, 34, 46, 104, 153, 223], 'express': [25], 'the': [26, 48, 68, 106, 116, 249], 'same': [27], 'channels,': [28], 'we': [29, 74], 'tested': [30], 'whether': [31, 76], 'EDHF': [32, 216, 245], 'hyperpolarizes': [33], 'and': [35, 184, 229], 'exerts': [36, 217], 'an': [37], 'antithrombotic': [38, 250], 'function': [39], 'vivo.': [41, 256], 'Interaction': [42], 'injected': [44], 'human': [45, 78, 93], 'with': [47, 169], 'arteriolar': [49, 107, 206], 'wall': [50, 52], '(platelet-vessel': [51], 'interaction,': [53], 'PVWI)': [54], 'was': [55, 99, 154, 185], 'assessed': [56], 'intravital': [58], 'microscopy': [59], 'skin': [61], 'awake': [64], 'hamsters.': [65], 'To': [66], 'understand': [67], 'mechanisms': [69], 'EDHF-induced': [71], 'platelet': [72, 174, 198, 203, 232, 240], 'inhibition,': [73], 'studied': [75], 'cultured': [77], 'umbilical': [79], 'vein': [80], 'endothelial': [81, 177], 'cells': [82, 178], 'overexpressing': [83], 'CYP2C9-mRNA': [84], 'vitro': [86, 183], 'released': [87], 'a': [88, 149, 212], 'that': [90, 237, 244], 'could': [91], 'hyperpolarize': [92], 'platelets.': [94], 'Under': [95], 'control': [96], 'conditions,': [97], 'there': [98], 'no': [100], 'firm': [101, 146], 'adhesion': [102, 147, 175, 233], 'to': [105, 123, 176], 'wall,': [108], 'but': [109], 'temporary': [110], 'PVWI': [111], 'occurred.': [112], 'Local': [113], 'superfusion': [114, 168], 'CYP2C9': [117, 160], 'inhibitor': [118], 'sulfaphenazole,': [119], 'at': [120], 'doses': [121], 'known': [122], 'block': [124], 'EDHF-dependent': [125], 'dilations,': [126], 'significantly': [127], 'augmented': [128], 'PVWI,': [129], 'as': [130], 'did': [131], 'inhibition': [132, 161], 'NO': [134], 'synthase.': [135], 'Inhibition': [136], 'both': [138], 'factors': [139], 'exerted': [140], 'additive': [141], 'effects': [142, 158, 219], 'on': [143, 187], 'PVWI.': [144], 'Likewise,': [145], 'small': [150], 'fraction': [151], 'observed.': [155], 'The': [156, 191, 205], 'prothrombotic': [157], 'vivo': [163, 209], 'were': [164], 'reversed': [165], 'exogenous': [167], '11,12-epoxyeicosatrienoic': [170], 'acids.': [171], 'Hyperpolarization': [172], 'reduced': [173, 194], 'under': [179], 'static': [180], 'conditions': [181], 'dependent': [186], 'calcium-activated': [188], 'also': [193], 'ADP-induced': [195], 'expression': [196], 'P-selectin,': [199], 'indicating': [200, 236], 'reduction': [201, 230], 'activity.': [204], 'endothelium': [207, 254], 'continuously': [210], 'releases': [211], 'CYP2C9-derived': [213], 'EDHF.': [214], 'This': [215, 242], 'its': [218], 'hyperpolarization': [221, 238], 'through': [224], 'activation': [225], 'KCa': [227], 'channels': [228], 'molecule': [234], 'expression,': [235], 'reduces': [239], 'activation.': [241], 'demonstrates': [243], 'is': [246], 'part': [247], 'properties': [251], 'healthy': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056273145', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-11T14:12:55.937821', 'created_date': '2016-06-24'}