Specificity of Interactions between mDia Isoforms and Rho Proteins

Name: Work Video:
Duration: 3 min 30 s
Michael Lammers; Simon F. De Meyer; Dorothee Kühlmann; Alfred Wittinghofer
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1767, 1850, 3520, 3530, 3569, 3571, 3835, 3902, 3910, 4031, 4037, 4302], 'formation': [25, 273, 571], 'linear': [27, 275], 'cables.': [29, 277], 'A': [30, 159, 278, 407, 3922], 'subclass': [31, 279, 1890], 'formins': [33, 281, 587, 719, 1019, 1893], 'constitutes': [34, 282], 'Diaphanous-related': [36, 284, 1892, 2172], 'formins,': [37, 285, 1597], 'members': [38, 286, 3570, 3753], 'which': [40, 97, 132, 288, 345, 380, 789, 1083, 1908, 2513, 2765, 4288], 'regulated': [42, 290, 579], 'by': [43, 85, 101, 145, 291, 333, 349, 393, 580, 714, 1261, 2340, 2779, 3244, 3259, 3455, 3599, 3636, 3801, 3812, 3826, 3957, 4090, 4248, 4318, 4396], 'binding': [45, 293, 1087, 1680, 2574, 2944, 3080, 3246, 3456, 3556, 3756, 3766, 3791, 3853], 'a': [47, 149, 153, 221, 295, 397, 401, 469, 573, 796, 922, 1079, 1085, 1267, 1283, 1895, 2058, 2159, 2519, 2614, 2619, 2748, 2760, 2942, 3086, 3127, 3382, 3388, 3403, 3789, 3802, 3827, 3843, 3964, 4028, 4145, 4164, 4176, 4185, 4220, 4250, 4260, 4436, 4546, 4552], 'small': [48, 296, 2204], 'GTP-binding': [49, 297, 2205], 'protein': [50, 298, 590, 930, 2061, 2152, 2996, 3209, 3385, 3742, 3993, 4008, 4240, 4452, 4476], 'Rho': [53, 86, 186, 205, 301, 334, 434, 453, 2209, 2444, 2461, 2568, 2756, 2937, 2991, 3082, 3119, 3245, 3303, 3326, 3352, 3362, 3384, 3425, 3458, 3751, 3779, 3821, 3847, 4094, 4265], 'subfamily.': [54, 302], 'Binding': [55, 303, 2201, 2934], 'these': [57, 305, 3115], 'molecular': [58, 306], 'switch': [59, 307, 2447, 2742, 3398], 'proteins': [60, 308, 712, 1624, 2174, 2206, 2607, 2694, 2757, 2785, 3120, 3304, 3327, 3353, 3435, 3559, 3762, 3871, 4053], 'to': [61, 71, 93, 169, 309, 319, 341, 417, 569, 920, 1091, 1275, 1681, 1686, 1692, 1838, 1885, 2057, 2212, 2515, 2753, 3081, 3126, 3250, 3329, 3360, 3371, 3439, 3595, 3630, 3736, 3749, 3882, 3963, 4219, 4224, 4367, 4435, 4498], 'regulatory': [63, 311, 1896], 'N-terminal': [64, 312, 1884], 'mDiaN,': [65, 313, 4369], 'including': [66, 314], 'GTPase-binding': [68, 316, 735], 'domain,': [69, 317, 781], 'leads': [70, 318, 568, 1837, 2056, 2211], 'release': [73, 321, 1840, 2214, 3192, 3241], 'auto-inhibition.': [75, 323], 'From': [76, 324, 1239], 'three': [78, 326, 2166, 2348], 'mDia': [79, 246, 327, 494, 3079, 3776], 'isoforms,': [80, 328], 'mDia1': [81, 125, 128, 164, 200, 329, 373, 376, 412, 448, 3223, 3239, 3592, 3808], 'is': [82, 98, 106, 143, 330, 346, 354, 391, 578, 790, 918, 932, 1604, 2229, 2733, 3083, 3117, 3409, 3528, 3588, 3597, 3738, 3799, 3810, 3824, 3849], 'activated': [83, 100, 331, 348, 2203, 2440, 3454, 3598, 3635], 'only': [84, 332, 3122, 3437, 3523], '(RhoA,': [87, 335], '-B,': [88, 336, 3368, 3601], '-C),': [90, 338], 'in': [91, 163, 173, 216, 228, 339, 411, 421, 464, 476, 506, 792, 924, 1037, 1247, 1521, 1526, 1906, 2156, 2162, 2178, 2437, 2518, 2696, 2766, 2936, 2946, 3202, 3216, 3309, 3358, 3406, 3590, 3741, 3815, 3851, 3874, 3920, 3938, 4024, 4206, 4271, 4289, 4351, 4410, 4416, 4455, 4504], 'contrast': [92, 340], 'mDia2': [94, 139, 342, 387, 3626, 3816], '-3,': [96, 344], 'also': [99, 231, 347, 479, 1776, 2357, 2455, 2471, 3134, 3215, 3833], 'Rac': [102, 217, 350, 465, 3374, 3461, 3573], 'Cdc42.': [104, 352, 3914, 4041], 'Little': [105, 353], 'known': [107, 355], 'about': [108, 356], 'determinants': [110, 358], 'specificity.': [112, 360, 3855], 'Here': [113, 361, 3768], 'we': [114, 362, 3769], 'report': [115, 363], 'on': [116, 134, 364, 382, 2467, 4009, 4321, 4541], 'interactions': [118, 366, 3116], 'RhoA,': [120, 368, 3367, 3533, 3600, 3911, 3941, 4038, 4358], 'Rac1,': [121, 369, 3912, 3942, 4039], 'Cdc42': [123, 219, 371, 467, 3372, 3463, 3575, 3787, 4129], 'with': [124, 184, 204, 224, 372, 432, 452, 472, 794, 1088, 1249, 1910, 2439, 2451, 2456, 2524, 2691, 2759, 2775, 2941, 3387, 3451, 3580, 3893, 3974, 3996, 4020, 4077, 4099, 4163, 4184, 4259, 4291, 4412, 4426, 4488, 4510, 4562], 'an': [127, 375, 503, 2511, 3003, 3194, 3306, 3883], 'mutant': [129, 377, 4200], '(mDiaN-Thr-Ser-His': [130, 378], '(TSH)),': [131, 379], 'based': [133, 381, 4320], 'structural': [135, 150, 383, 398, 3088], 'information': [136, 384], 'should': [137, 385], 'mimic': [138, 386], '-3.': [141, 389, 3818], 'Specificity': [142, 390], 'analyzed': [144, 392, 3770, 4391], 'biochemical': [146, 394, 1254], 'studies': [147, 395], 'analysis': [151, 399], 'complex': [154, 402, 567, 1248, 2438, 4258, 4411], 'between': [155, 403, 2219, 2613, 3532, 3775], 'Cdc42·Gpp(NH)p': [156, 404], 'mDiaN-TSH.': [158, 406], 'triple': [160, 196, 408, 444], 'NNN': [161, 409], 'motif': [162, 172, 198, 227, 410, 420, 446, 475, 2945, 3006, 3089, 3557, 3806], '(amino': [165, 175, 413, 423], 'acids': [166, 176, 414, 424], '164-166),': [167, 415], 'corresponding': [168, 214, 416, 462], 'TSH': [171, 226, 419, 474], 'mDia2/3': [174, 422], '183-185': [177, 425], '190-192),': [179, 427], 'epitope': [182, 430], 'interacting': [183, 431], 'insert': [187, 435, 2462, 3841], 'helix': [188, 436], 'essential': [190, 438], 'high': [192, 440, 1089, 3404], 'affinity': [193, 441, 1090], 'binding.': [194, 442], 'The': [195, 443, 496, 915, 1018, 1068, 1515, 2049, 2150, 2432, 2464, 2495, 2990, 3111, 3300, 3554, 3734, 3991, 4153, 4213, 4227, 4242, 4373, 4388, 4451, 4533], 'N': [197, 445], 'allows': [201, 449], 'tight': [202, 450], 'interaction': [203, 451, 2218, 3774, 4307], 'because': [206, 454, 2734], 'presence': [209, 457], 'Phe-106,': [211, 459], 'whereas': [212, 460, 3078, 3625], 'His-104': [215, 463], 'forms': [220, 468, 1084], 'complementary': [222, 470], 'interface': [223, 471, 3408], 'mDia2/3.': [229, 477], 'We': [230, 478, 3781, 3832], 'show': [232, 480, 3782], 'that': [233, 481, 1286, 1614, 2062, 2228, 2344, 2443, 2498, 2746, 3118, 3132, 3198, 3436, 3519, 3591, 3783, 3794, 3809, 3839], 'F106H': [235, 483], 'H104F': [237, 485], 'mutations': [238, 486, 4043], 'drastically': [239, 487], 'alter': [240, 488], 'affinities': [242, 490], 'thermodynamics': [244, 492], 'interactions.': [247, 495], 'dynamics': [497], 'cytoskeleton': [501, 2771, 3315], 'play': [502, 921], 'important': [504, 3307, 3529], 'role': [505, 923, 3308], 'many': [507], 'physiological': [508], 'processes,': [509], 'e.g.': [510, 3207], 'cytokinesis,': [511], 'cell': [512, 514], 'migration,': [513], 'morphology,': [515], 'phagocytosis': [517], '(1.Castrillon': [518], 'D.H.': [519], 'Wasserman': [520], 'S.A.': [521], 'Development': [522], '(Camb.).': [523], '1994;': [524], '120:': [525], '3367-3377Crossref': [526], 'PubMed': [527, 541, 559, 614, 629, 646, 664, 687, 704, 814, 832, 859, 879, 910, 953, 976, 999, 1013, 1063, 1119, 1141, 1156, 1175, 1206, 1234, 1314, 1345, 1367, 1392, 1407, 1424, 1443, 1464, 1489, 1510, 1550, 1575, 1590, 1642, 1658, 1674, 1735, 1756, 1806, 1831, 1879, 1929, 1947, 1972, 1993, 2014, 2044, 2086, 2101, 2124, 2145, 2196, 2247, 2265, 2290, 2311, 2331, 2386, 2407, 2427, 2490, 2541, 2562, 2599, 2650, 2671, 2684, 2708, 2726, 2794, 2809, 2821, 2834, 2862, 2876, 2892, 2914, 2929, 2963, 2985, 3016, 3046, 3073, 3106, 3151, 3165, 3184, 3233, 3275, 3295, 3345, 3480, 3510, 3551, 3620, 3666, 3687, 3704, 3729, 4122, 4338], 'Google': [528, 544, 562, 617, 632, 649, 667, 690, 707, 817, 835, 862, 882, 913, 956, 977, 1002, 1016, 1066, 1122, 1144, 1159, 1178, 1209, 1237, 1317, 1348, 1370, 1395, 1410, 1427, 1446, 1467, 1492, 1513, 1553, 1578, 1593, 1645, 1661, 1677, 1738, 1759, 1809, 1834, 1882, 1932, 1950, 1975, 1996, 2017, 2047, 2089, 2104, 2127, 2148, 2199, 2250, 2268, 2293, 2314, 2334, 2389, 2410, 2430, 2493, 2544, 2565, 2602, 2653, 2674, 2687, 2711, 2729, 2797, 2810, 2824, 2837, 2865, 2879, 2895, 2917, 2932, 2966, 2988, 3019, 3049, 3076, 3109, 3154, 3168, 3187, 3236, 3278, 3298, 3348, 3422, 3483, 3513, 3552, 3623, 3669, 3690, 3707, 3732, 4125, 4341, 4576], 'Scholar,': [529, 545, 618, 633, 650, 668, 691, 818, 836, 863, 883, 957, 978, 1003, 1123, 1145, 1160, 1179, 1210, 1318, 1349, 1371, 1396, 1411, 1428, 1447, 1468, 1493, 1554, 1579, 1646, 1662, 1739, 1810, 1933, 1951, 1976, 1997, 2018, 2090, 2105, 2128, 2251, 2269, 2294, 2315, 2390, 2411, 2545, 2654, 2675, 2712, 2798, 2811, 2825, 2838, 2866, 2880, 2896, 2918, 2967, 3020, 3050, 3155, 3169, 3279, 3484, 3670, 3691, 3708], '2.Pantaloni': [530], 'D.': [531, 670, 843, 847, 1187, 1220, 1298, 1302, 1534, 1538, 1790, 1794, 1863, 1867, 2971], 'Le': [532, 839, 1294, 1530, 1786, 1859], 'Clainche': [533, 840, 1295, 1531, 1787, 1860], 'C.': [534, 674, 682, 807, 841, 845, 889, 891, 1098, 1100, 1166, 1168, 1296, 1300, 1324, 1326, 1373, 1499, 1532, 1536, 1556, 1633, 1635, 1714, 1716, 1745, 1788, 1792, 1812, 1861, 1865, 1955, 2273, 2369, 3339], 'Carlier': [535, 848, 1303, 1539, 1795, 1868], 'M.F.': [536, 849, 1304, 1540, 1796, 1869], 'Science.': [537, 683, 1388, 1571, 1827, 2680, 2704, 2790], '2001;': [538, 973, 996, 1921, 2121, 2239, 2681, 2705, 2791], '292:': [539], '1502-1506Crossref': [540], 'Scopus': [542, 560, 615, 630, 647, 665, 688, 705, 815, 833, 860, 880, 911, 954, 1000, 1014, 1064, 1120, 1142, 1157, 1176, 1207, 1235, 1315, 1346, 1368, 1393, 1408, 1425, 1444, 1465, 1490, 1511, 1551, 1576, 1591, 1643, 1659, 1675, 1736, 1757, 1807, 1832, 1880, 1930, 1948, 1973, 1994, 2015, 2045, 2087, 2102, 2125, 2146, 2197, 2248, 2266, 2291, 2312, 2332, 2387, 2408, 2428, 2491, 2542, 2563, 2600, 2651, 2672, 2685, 2709, 2727, 2795, 2822, 2835, 2863, 2877, 2893, 2915, 2930, 2964, 2986, 3017, 3047, 3074, 3107, 3152, 3166, 3185, 3234, 3276, 3296, 3346, 3420, 3481, 3511, 3621, 3667, 3688, 3705, 3730, 4123, 4339, 4574], '(565)': [543], '3.Pollard': [546], 'T.D.': [547, 602, 1056, 1400, 1417, 1583], 'Borisy': [548, 603], 'G.G.': [549, 604], 'Cell.': [550, 605, 850, 994, 1059, 1152, 1197, 1225, 1305, 1420, 1541, 1797, 1870, 1963, 2097, 2281, 2377, 2853, 2885, 3064, 3546], '2003;': [551, 606, 811, 871, 902, 945, 1111, 1172, 1337, 1435, 1481, 1639, 1727, 2078, 2188, 3267, 3701], '112:': [552, 607], '453-465Abstract': [553, 608], 'Full': [554, 556, 609, 611, 827, 829, 854, 856, 874, 876, 905, 907, 948, 950, 1114, 1116, 1136, 1138, 1201, 1203, 1229, 1231, 1309, 1311, 1340, 1342, 1362, 1364, 1438, 1440, 1484, 1486, 1545, 1547, 1730, 1732, 1801, 1803, 1874, 1876, 1924, 1926, 1967, 1969, 2081, 2083, 2191, 2193, 2242, 2244, 2285, 2287, 2326, 2328, 2381, 2383, 2422, 2424, 2557, 2559, 2645, 2647, 2723, 2857, 2859, 2889, 2911, 2980, 2982, 3041, 3043, 3068, 3070, 3270, 3272, 3290, 3292], 'Text': [555, 557, 610, 612, 828, 830, 855, 857, 875, 877, 906, 908, 949, 951, 1115, 1117, 1137, 1139, 1202, 1204, 1230, 1232, 1310, 1312, 1341, 1343, 1363, 1365, 1439, 1441, 1485, 1487, 1546, 1548, 1731, 1733, 1802, 1804, 1875, 1877, 1925, 1927, 1968, 1970, 2082, 2084, 2192, 2194, 2243, 2245, 2286, 2288, 2327, 2329, 2382, 2384, 2423, 2425, 2558, 2560, 2646, 2648, 2724, 2858, 2860, 2890, 2912, 2981, 2983, 3042, 3044, 3069, 3071, 3271, 3273, 3291, 3293], 'PDF': [558, 613, 831, 858, 878, 909, 952, 1118, 1140, 1205, 1233, 1313, 1344, 1366, 1442, 1488, 1549, 1734, 1805, 1878, 1928, 1971, 2085, 2195, 2246, 2289, 2330, 2385, 2426, 2561, 2649, 2725, 2861, 2891, 2913, 2984, 3045, 3072, 3274, 3294], '(3303)': [561, 616], 'Scholar).': [563, 708, 914, 1017, 1067, 1238, 1514, 1594, 1678, 1760, 1835, 1883, 2048, 2149, 2200, 2335, 2431, 2494, 2566, 2603, 2688, 2730, 2933, 2989, 3110, 3188, 3237, 3299, 3349, 3423, 3514, 3553, 3733, 4126], 'Although': [564], 'Arp2/3': [566], 'branched': [574], 'network': [576], 'WASP': [581], 'VASP': [583], 'others,': [585], 'Spire': [591], 'catalyze': [592], 'polymerization': [596, 1260, 3256], 'unbranched': [598], 'filaments': [600, 1281], '(3.Pollard': [601], '4.Bompard': [619], 'G.': [620, 2028, 3650], 'Caron': [621], 'E.': [622, 676, 697, 3542], 'J.': [623, 640, 808, 897, 970, 1106, 1130, 1332, 1356, 1381, 1458, 1564, 1654, 1722, 1820, 1918, 1943, 2040, 2236, 2261, 2320, 2416, 2486, 2537, 2595, 2639, 2664, 2803, 2817, 2848, 2923, 2959, 2974, 3012, 3034, 3035, 3145, 3161, 3229, 3284, 3506, 3662, 4568], 'Cell': [624, 809, 869, 943, 971, 1008, 1402, 1459, 1585, 2119, 2140, 2186, 2804, 2924, 3475, 3615, 3682, 3699], 'Biol.': [625, 642, 870, 901, 944, 995, 1009, 1058, 1110, 1131, 1151, 1336, 1357, 1403, 1419, 1434, 1460, 1480, 1586, 1726, 1919, 1987, 2077, 2096, 2120, 2141, 2187, 2237, 2321, 2417, 2640, 2872, 2975, 3036, 3147, 3266, 3285, 3476, 3547, 3616, 3683, 3700], '2004;': [626, 643, 851, 1010, 1133, 1198, 1226, 1306, 1359, 1389, 1404, 1542, 1572, 1587, 1798, 1828, 1871, 2854, 2873, 2926, 3148, 3417, 3726], '166:': [627], '957-962Crossref': [628], '(120)': [631], '5.Buck': [634], 'M.': [635, 657, 672, 803, 887, 899, 986, 1096, 1108, 1162, 1164, 1183, 1322, 1334, 1503, 1629, 1631, 1668, 1712, 1724, 1749, 1935, 1959, 1982, 2001, 2003, 2111, 2253, 2277, 2298, 2300, 2373, 2394, 2396, 2478, 2529, 2551, 2587, 2628, 2632, 2868, 3022, 3030, 3093, 3095, 3140, 3488, 3494, 3496, 3697, 3716, 4109, 4111], 'Xu': [636, 3141], 'W.': [637, 2658, 3142, 4567], 'Rosen': [638, 1452, 1504, 1750, 1960, 2278, 2374, 3143, 3172], 'M.K.': [639, 1453, 1505, 1751, 1961, 2279, 2375, 3144, 3173], 'Mol.': [641, 993, 1057, 1150, 1196, 1418, 1962, 2095, 2280, 2376, 3063, 3146, 3545], '338:': [644, 3149], '271-285Crossref': [645, 3150], '(46)': [648, 3153, 3186], '6.Eden': [651], 'S.R.': [652], 'Rohatgi': [653, 2841], 'A.V.': [654], 'Podtelejnikov': [655], 'Mann': [656], 'Kirschner': [658, 2851], 'M.W.': [659, 2852], 'Nature.': [660, 700, 1506, 1752, 2010, 2307, 2403, 2667, 2830, 3102, 3725, 4118], '2002;': [661, 684, 1671, 2098, 2806, 2831], '418:': [662], '790-793Crossref': [663], '(652)': [666], '7.Pruyne': [669], 'Evangelista': [671, 886, 1095, 1163, 1321, 1630, 1711], 'Yang': [673, 890, 1099, 1167, 1325, 1634, 1715], 'Bi': [675], 'Zigmond': [677, 804, 1169, 1636], 'S.H.': [678, 885, 1005, 1094, 1170, 1320, 1637, 1710], 'Bretscher': [679], 'A.': [680, 965, 1181, 1195, 1377, 1455, 1472, 1560, 1816, 1939, 1941, 1980, 2009, 2030, 2134, 2257, 2259, 2306, 2402, 2482, 2484, 2533, 2535, 2547, 2591, 2593, 2666, 2679, 2703, 2714, 2789, 2815, 2829, 2870, 2884, 2957, 2973, 3010, 3101, 3159, 3180, 3227, 3469, 3502, 3609, 3652, 3676, 4117], 'Boone': [681, 806, 888, 1097, 1165, 1323, 1632, 1713], '297:': [685], '612-615Crossref': [686], '(578)': [689], '8.Quinlan': [692], 'M.E.': [693], 'Heuser': [694], 'J.E.': [695], 'Kerkhoff': [696], 'Mullins': [698], 'R.D.': [699], '2005;': [701, 824, 1060, 1153, 1421, 1461, 1507, 1753, 1944, 1964, 1990, 2011, 2262, 2282, 2308, 2323, 2378, 2404, 2419, 2487, 2538, 2596, 3103, 3181, 3287, 4119], '433:': [702, 1508, 1754], '382-388Crossref': [703], '(260)': [706], 'multidomain': [711], 'characterized': [713], 'domains.': [717], 'All': [718, 3870, 4180, 4267, 4346], 'FH2': [722, 1072, 1244, 1272, 1707, 2227, 3260], '2The': [723], 'abbreviations': [724], 'used': [725, 4205, 4301], 'are:': [726], 'FH,': [727], 'homology;': [729], 'Bistris': [730, 4420], 'propane,': [731, 4421], '1,': [732], '3-bis[tris(hydroxymethyl)methylamino]propane;': [733], 'GBD,': [734], 'domain;': [736, 750, 753], 'Dia,': [737], 'Diaphanous;': [738], 'mant,': [739], 'N-methylanthraniloyl;': [740], 'Gpp(NH)p,': [741], 'guanosine': [742], '5′-(β,γ-imido)triphosphate;': [743], 'ARR,': [744], 'Armadillo': [745, 755, 2353], 'repeat': [746, 756, 2354], 'region;': [747, 761], 'DID,': [748], 'Diaphanous-inhibitory': [749], 'DAD,': [751, 4357], 'Diaphanous-autoregulatory': [752, 1913], 'ARM,': [754], 'motif;': [757], 'DCR,': [758], 'DAD': [759, 2055, 2220, 2506, 2571], 'core': [760, 2507], 'GNBP,': [762, 2609], 'guanine': [763, 2605], 'nucleotide-binding': [764, 2606], 'protein;': [765], 'PDB,': [766], 'Protein': [767], 'Data': [768, 4400, 4515, 4556], 'Bank;': [769], 'ITC,': [770], 'isothermal': [771], 'titration': [772], 'calorimetry;': [773], 'WT,': [774], 'wild': [775, 4058, 4197], 'type;': [776], 'ROCK,': [777, 3208], 'Rho-associated': [778], 'coiled-coil': [779, 3005], 'kinase.': [780], 'actual': [783], 'polymerization,': [788], 'often': [791], 'tandem': [793, 1599], 'FH1,': [795, 1687], 'polyproline': [797], 'domain': [798, 917, 937, 1073, 1708, 1914, 2364, 4408], 'mediating': [799], 'profilin·actin': [800], 'recruitment': [801], '(9.Evangelista': [802], 'S.': [805, 838, 969, 1191, 1293, 1385, 1529, 1568, 1666, 1785, 1824, 1858, 2038, 2117, 2138, 2626, 2634, 2827, 3028, 3058, 3179, 3473, 3613, 3660, 3680, 3693, 3710, 3718, 3724, 4328], 'Sci.': [810, 823, 972, 2719, 2805, 2907, 2925, 3177], '116:': [812, 1227], '2603-2611Crossref': [813], '(231)': [816], '10.Higgs': [819], 'H.N.': [820, 1129, 1147, 1355, 1432, 2075, 2319, 2415, 3264, 3283], 'Trends': [821, 868, 942, 2185, 2717, 2905], 'Biochem.': [822, 2718, 2816, 2906, 2958, 3011, 3160, 3228, 4334], '30:': [825], '342-353Abstract': [826], '(310)': [834, 881, 955, 2198], '11.Romero': [837], 'Didry': [842, 1297, 1533, 1789, 1862], 'Egile': [844, 1299, 1535, 1791, 1864], 'Pantaloni': [846, 1301, 1537, 1793, 1866], '119:': [852, 1307, 1543, 1799, 1872], '419-429Abstract': [853, 1308, 1544, 1800, 1873], '(440)': [861, 1316, 1552, 1808, 1881], '12.Wallar': [864], 'B.J.': [865, 939, 2182], 'Alberts': [866, 940, 2183], 'A.S.': [867, 941, 1917, 2184, 2235], '13:': [872, 903, 946, 1112, 1199, 1338, 1436, 1482, 1728, 2079, 2099, 2189, 3268], '435-446Abstract': [873, 947, 2190], '13.Zigmond': [884, 1319], 'Dar': [892, 1101, 1327, 1717], 'A.C.': [893, 1102, 1328, 1718], 'Sicheri': [894, 1103, 1329, 1719], 'F.': [895, 1104, 1127, 1218, 1330, 1353, 1379, 1430, 1562, 1720, 1818, 2073, 2317, 2413, 2549, 3262, 3281, 3712], 'Forkey': [896, 1105, 1331, 1721], 'Pring': [898, 1107, 1333, 1723], 'Curr.': [900, 1006, 1109, 1335, 1433, 1479, 1725, 2076, 3265], '1820-1823Abstract': [904, 1113, 1339, 1729], '(218)': [912, 1121, 1347, 1737, 2016, 2313, 2409, 3108, 4124], 'FH3': [916, 1903], 'believed': [919], 'subcellular': [926], 'localization': [927], 'least': [934], 'conserved': [935, 2502, 3397], 'FH': [936], '(12.Wallar': [938, 2181], '14.Kato': [958], 'T.': [959, 967, 988, 1375, 1449, 1451, 1495, 1558, 1741, 1814, 1953, 2005, 2024, 2026, 2107, 2113, 2115, 2132, 2136, 2271, 2302, 2367, 2398, 2630, 2638, 2900, 3056, 3062, 3097, 3467, 3471, 3486, 3490, 3498, 3538, 3607, 3611, 3646, 3648, 3674, 3678, 3714, 3722, 4113, 4326], 'Watanabe': [960, 1386, 1569, 1825, 2027, 3649], 'N.': [961, 1387, 1570, 1826, 2020, 2130, 3465, 3605, 3642, 3672], 'Morishima': [962, 2108], 'Y.': [963, 982, 992, 1212, 1383, 1476, 1566, 1822, 2032, 2109, 2898, 3654, 3695, 3720], 'Fujita': [964, 1376, 1559, 1815, 2133, 3468, 3608, 3675], 'Ishizaki': [966, 2004, 2025, 2135, 2301, 2397, 3096, 3470, 3610, 3647, 3677, 3721, 4112], 'Narumiya': [968, 1190, 1384, 1567, 1823, 2037, 2116, 2137, 3472, 3612, 3659, 3679, 3723], '114:': [974], '775-784Crossref': [975], '15.Ozaki-Kuroda': [979], 'K.': [980, 990, 1474, 2034, 2624, 2636, 2902, 2920, 3024, 3054, 3060, 3492, 3500, 3504, 3656], 'Yamamoto': [981, 3489], 'Nohara': [983], 'H.': [984, 2904], 'Kinoshita': [985], 'Fujiwara': [987], 'Irie': [989], 'Takai': [991], '21:': [997], '827-839Crossref': [998], '(129)': [1001], '16.Zigmond': [1004], 'Opin.': [1007], '16:': [1011, 1061, 1154, 1422, 1656, 2042, 2721, 3549, 3664], '99-105Crossref': [1012], '(205)': [1015], 'subdivided': [1021], 'into': [1022], 'seven': [1023], 'groups': [1024], 'follows:': [1026, 2351], 'Dia': [1027], '(diaphanous),': [1028], 'DAAM': [1029], '(dishevelled-associated': [1030], 'activator': [1031], 'morphogenesis),': [1033], 'FRL': [1034], '(formin-related': [1035], 'gene': [1036, 2160], 'leukocytes),': [1038], 'FHOD': [1039], '(formin': [1040], 'domain-containing': [1042, 1623], 'protein),': [1043], 'INF': [1044], '(inverted': [1045], 'formin),': [1046], 'FMN': [1047], '(formin),': [1048], 'delphilin': [1050], '(24.Kovar': [1051], 'D.R.': [1052, 1398, 1413, 1497, 1581, 1743, 1957, 2275, 2371], 'Wu': [1053, 1414], 'J.Q.': [1054, 1415], 'Pollard': [1055, 1399, 1416, 1582], '2313-2324Crossref': [1062, 1423], '(98)': [1065, 1426], 'structure': [1069, 1241, 2433, 2496], 'from': [1074, 1253, 1843, 2207, 2572, 4082, 4234], 'yeast': [1075], 'mouse': [1077], 'showed': [1078], 'doughnut-shaped': [1080], 'all-helical': [1081], 'molecule,': [1082], 'dimer': [1086, 1273], '(13.Zigmond': [1093, 1709], '17.Harris': [1124, 1350], 'E.S.': [1125, 1351], 'Li': [1126, 1352, 2847], 'Higgs': [1128, 1354, 1431, 2074, 2318, 2414, 3263, 3282], 'Chem.': [1132, 1358, 1920, 2238, 2322, 2418, 2641, 2976, 3037, 3286], '279:': [1134, 1360], '20076-20087Abstract': [1135, 1361], '(167)': [1143, 1369], '18.Higgs': [1146], 'Peterson': [1148], 'K.J.': [1149], '1-13Crossref': [1155], '(206)': [1158], '19.Pring': [1161], 'Biochemistry.': [1171, 1638], '42:': [1173, 1640], '486-496Crossref': [1174, 1641], '(190)': [1177, 1644, 1660], '20.Shimada': [1180], 'Nyitrai': [1182], 'Vetter': [1184], 'I.R.': [1185, 2677, 2701, 2787], 'Kuhlmann': [1186], 'Bugyi': [1188], 'B.': [1189], 'Geeves': [1192], 'M.A.': [1193, 1470], 'Wittinghofer': [1194, 1940, 1979, 2008, 2258, 2305, 2401, 2483, 2534, 2592, 2665, 2678, 2702, 2788, 3100, 4116], '511-522Abstract': [1200], '(118)': [1208], '21.Xu': [1211], 'Moseley': [1213], 'J.B.': [1214], 'Sagot': [1215], 'I.': [1216, 2802], 'Poy': [1217, 2548], 'Pellman': [1219], 'Goode': [1221], 'B.L.': [1222], 'Eck': [1223, 2550], 'M.J.': [1224, 1664], '711-723Abstract': [1228], '(288)': [1236], 'alone': [1245], 'tetramethylrhodamine-labeled': [1250], 'experiments,': [1255], 'mechanism': [1257], 'was': [1264, 2154, 3961, 3972, 3994, 4018, 4095, 4158, 4173, 4232, 4300, 4316, 4378, 4386, 4453, 4486, 4536], 'described': [1265, 2473, 3430, 4104], 'stair-stepping': [1268], 'mechanism,': [1269], 'where': [1270], 'binds': [1274, 2514, 3594, 3748], 'barbed': [1277, 1694, 1772], 'ends': [1278], 'leaky': [1284], 'capper': [1285], 'processively': [1287], 'catalyzes': [1288], 'barbed-end': [1289, 1845], 'assembly': [1291], '(11.Romero': [1292, 1528, 1784, 1857], '22.Higashida': [1372, 1555, 1811], 'Miyoshi': [1374, 1557, 1813], 'Oceguera-Yanez': [1378, 1561, 1817, 3711], 'Monypenny': [1380, 1563, 1819], 'Andou': [1382, 1565, 1821], '303:': [1390, 1573, 1829], '2007-2010Crossref': [1391, 1574, 1830], '(251)': [1394, 1577, 1833], '23.Kovar': [1397, 1580], 'Nat.': [1401, 1584, 2118, 2139, 3474, 3614, 3681, 3698], '6:': [1405, 1588], '1158-1159Crossref': [1406, 1589], '(42)': [1409, 1592], '24.Kovar': [1412], '25.Li': [1429], '1335-1340Abstract': [1437, 2080, 3269], '(347)': [1445, 2088, 3277], '26.Shemesh': [1448], 'Otomo': [1450, 1498, 1744, 1954, 2272, 2368], 'Bershadsky': [1454], 'Kozlov': [1456], 'M.M.': [1457], '170:': [1462], '889-893Crossref': [1463], '(45)': [1466], '27.Wear': [1469], 'Yamashita': [1471], 'Kim': [1473], 'Maéda': [1475], 'Cooper': [1477], 'J.A.': [1478], '1531-1537Abstract': [1483], '(114)': [1491], '28.Otomo': [1494, 1740], 'Tomchick': [1496, 1742, 1956, 2274, 2370], 'Panchal': [1500, 1746], 'S.C.': [1501, 1747], 'Machius': [1502, 1748, 1958, 2276, 2372], '488-494Crossref': [1509, 1755], '(290)': [1512, 1758], 'processive': [1516], 'movement': [1517], 'could': [1518], 'be': [1519, 3200, 3631], 'shown': [1520, 2339], 'vitro': [1522], 'well': [1524, 1684], 'vivo': [1527], 'For': [1595, 3238], 'most': [1596, 3795], 'arrangement': [1600], 'FH1-FH2': [1602, 1762], 'necessary': [1605], 'function.': [1607], 'FH1': [1608], 'contains': [1609, 1894], 'several': [1610], 'stretches': [1611], 'poly-l-prolines': [1613], 'targets': [1616], 'Src': [1618], '3': [1620], 'WW': [1622], 'profilin': [1627, 1688, 1842], '(19.Pring': [1628], '29.Bedford': [1647], 'M.T.': [1648], 'Chan': [1649], 'D.C.': [1650], 'Leder': [1651], 'P.': [1652, 2022, 3032, 3644], 'EMBO': [1653, 1942, 2039, 2260, 2485, 2536, 2594, 3415, 3505, 3661], '1997;': [1655, 2041, 3342, 3663], '2376-2383Crossref': [1657], '30.Macias': [1663], 'Wiesner': [1665], 'Sudol': [1667], 'FEBS': [1669], 'Lett.': [1670], '513:': [1672], '30-37Crossref': [1673], '(393)': [1676], 'By': [1679], 'G-actin': [1682, 1855], 'delivers': [1689], 'monomers': [1691, 1769], 'end': [1695], 'filament': [1698], 'increases': [1700], 'concentration': [1702, 4187], 'near': [1705], 'Therefore,': [1761], 'accelerates': [1763, 1777], 'association': [1765, 4228], 'rate': [1766, 1780, 4229, 4244], 'ATP-G-actin': [1768], 'at': [1770, 3754, 3899, 3907, 4013, 4071, 4141, 4160, 4354, 4521, 4538, 4545], 'end,': [1773], 'but': [1774, 2454, 3131, 3214, 3459, 3576], 'it': [1775], 'hydrolysis': [1779], 'actin-bound': [1782], 'ATP': [1783], 'This': [1836, 2731, 3189], 'making': [1846], 'this': [1847], 'site': [1848, 2466, 2520, 2527, 2575, 3130, 3792], 'accessible': [1849], 'next': [1852], 'round': [1853], 'incorporation': [1856], 'FH1/FH2': [1887], 'domains,': [1888], 'unit': [1897], 'consisting': [1898], 'GBD': [1901, 2053, 2453], '(mDiaN': [1905], 'short),': [1907], 'interact': [1909, 2690, 2758, 3450, 3579], 'C-terminal': [1912], '(DAD)': [1915], '(31.Alberts': [1916, 2234], '276:': [1922, 2240], '2824-2830Abstract': [1923, 2241], '(278)': [1931, 2249], '32.Lammers': [1934, 2252], 'Rose': [1936, 2254, 2479, 2530, 2588], 'R.': [1937, 1978, 1999, 2094, 2255, 2296, 2392, 2480, 2531, 2589, 2800, 2842, 3052, 3091, 3412, 4107], 'Scrima': [1938, 2256, 2481, 2532, 2590], '24:': [1945, 2263, 2488, 2539, 2597], '4176-4187Crossref': [1946, 2264, 2489, 2540, 2598], '(136)': [1949, 2267, 2492, 2543, 2601], '33.Otomo': [1952, 2270], '18:': [1965, 2283, 2379], '273-281Abstract': [1966, 2284, 2380], '(195)': [1974, 2292, 2388], '34.Rose': [1977], 'Weyand': [1981, 2000, 2297, 2393, 3092, 4108], 'Acta': [1983], 'Crystallogr.': [1984, 4570], 'F': [1985], 'Struct.': [1986], 'Crystalliz.': [1988], 'Comm.': [1989], '61:': [1991], '225-227Crossref': [1992], '(8)': [1995], '35.Rose': [1998, 2295, 2391], 'Lammers': [2002, 2299, 2395, 3094, 4110], 'Ahmadian': [2006, 2303, 2399, 3098, 3413, 4114], 'M.R.': [2007, 2304, 2400, 3099, 3414, 4115], '435:': [2012, 2309, 2405, 3104, 4120], '513-518Crossref': [2013, 2310, 2406, 3105, 4121], '36.Watanabe': [2019], 'Madaule': [2021, 3643], 'Reid': [2023, 3645], 'Kakizuka': [2029, 3651], 'Saito': [2031, 3653], 'Nakao': [2033, 3655], 'Jockusch': [2035, 3657], 'B.M.': [2036, 3658], '3044-3056Crossref': [2043, 3665], '(688)': [2046, 3668], 'deletion': [2050], 'either': [2052, 2772, 3361, 3572], 'or': [2054, 2777, 3212, 3331, 3370, 3462, 3574, 3758, 4035, 4199], 'constitutively': [2059], 'active': [2060, 2621], 'induces': [2063], 'stress': [2065], 'fibers': [2066], 'serum-response': [2068], 'factor-dependent': [2069], 'nuclear': [2070], 'transcription': [2071], '(25.Li': [2072, 3261], '37.Copeland': [2091], 'J.W.': [2092], 'Treisman': [2093], '4088-4099Crossref': [2100], '(163)': [2103], '38.Ishizaki': [2106], 'Okamoto': [2110, 3715], 'Furuyashiki': [2112], 'Kato': [2114, 2131, 2627, 3466, 3606, 3673, 3713], '3:': [2122], '8-14Crossref': [2123], '(284)': [2126], '39.Watanabe': [2129, 3671], '1999;': [2142, 3065, 3477, 3617, 3684], '1:': [2143, 3478, 3618, 3685], '136-143Crossref': [2144, 3479, 3619, 3686], '(727)': [2147, 3482, 3622, 3689], 'Drosophila': [2151, 2157], 'Diaphanous': [2153], 'isolated': [2155], 'involved': [2161, 3850], 'cytokinesis.': [2163], 'There': [2164], 'mammalian': [2167], 'homologues': [2168, 3377], 'mDia1-3': [2169], 'two': [2171, 2739], 'Bni1p': [2175], 'Bnr1p': [2177], 'Saccharomyces': [2179], 'cerevisiae': [2180], 'family': [2210, 3426, 3752], 'inhibitory': [2217], 'mDiaN': [2222, 2345, 2436, 2468, 3903, 4032, 4063, 4201], 'activation': [2224, 3252, 3301], 'not': [2230, 2521, 3121, 3248, 3356, 3460, 3578], 'yet': [2231], 'completely': [2232], 'understood': [2233], '40.Li': [2316, 2412, 3280], '280:': [2324, 2420, 3288], '6986-6992Abstract': [2325, 2421, 3289], '(146)': [2333, 2429, 3297], 'It': [2336, 3515], 'has': [2337, 2470, 3516, 4518], 'been': [2338, 2472, 3429, 3517, 4519], 'us': [2341], 'others': [2343, 3565], 'consists': [2346], 'subdomains': [2349], 'GBDN,': [2352], 'region': [2355, 2508], '(ARR)': [2356], 'called': [2358], 'DID': [2359], '(Diaphanous-inhibitory': [2360], 'domain),': [2361], 'dimerization': [2363], '(Dim)': [2365], '(33.Otomo': [2366], 'RhoC': [2441], 'shows': [2442, 2497], 'interacts': [2445, 3386], 'via': [2446, 2459, 2576, 3002, 3085, 3325, 3394], 'I': [2448, 2743, 3399, 3444], 'II': [2450, 3401, 3446, 3522], 'ARR': [2458, 2517], 'helix.': [2463], 'DAD-binding': [2465], '(DID)': [2469], 'biochemically': [2474], 'structurally': [2476, 3391], '(32.Lammers': [2477, 2528, 2586], '16': [2500], 'highly': [2501, 3396, 3632], 'residues': [2503], '(DCR)': [2509], 'form': [2510, 2617, 2622, 2699], 'α-helix,': [2512], 'directly': [2522], 'overlapping': [2523, 3332], 'Rho-binding': [2526], '41.Nezami': [2546], 'Structure': [2552, 4403], '(Lond.).': [2553], '2006;': [2554, 3038], '14:': [2555], '257-263Abstract': [2556], '(83)': [2564], 'Nevertheless,': [2567], 'actively': [2569], 'dissociates': [2570], 'its': [2573, 3364, 3376], 'long': [2577], 'range': [2578, 2583], 'electrostatic': [2579], 'repulsion': [2580], 'short': [2582], 'steric': [2584], 'clashes': [2585], 'Small': [2604], '(small': [2608], 'G': [2610, 3761], 'proteins)': [2611, 4257], 'cycle': [2612], 'GDP-bound': [2615], 'inactive': [2616], 'GTP-bound': [2620, 2698, 3441], '(42.Ihara': [2623], 'Muraguchi': [2625], 'Shimizu': [2629, 3055], 'Shirakawa': [2631], 'Kuroda': [2633, 3057], 'Kaibuchi': [2635, 3059, 3503], 'Hakoshima': [2637, 3061], '1998;': [2642], '273:': [2643], '9656-9966Abstract': [2644], '(173)': [2652], '43.Pai': [2655], 'E.F.': [2656, 2716], 'Kabsch': [2657], 'Krengel': [2659], 'U.': [2660, 3178], 'Holmes': [2661], 'K.C.': [2662], 'John': [2663], '1989;': [2668, 4335], '341:': [2669], '209-214Crossref': [2670], '(691)': [2673], '44.Vetter': [2676], '294:': [2682, 2706, 2792], '1299-1304Crossref': [2683, 2707, 2793], '(1395)': [2686, 2710, 2796], 'their': [2692, 3124, 4499], 'effector': [2693, 3138, 3747, 3852], 'preferentially': [2695], '(44.Vetter': [2700, 2786], '45.Wittinghofer': [2713], 'Pai': [2715], '1991;': [2720], '382-387Abstract': [2722], '(238)': [2728], 'discrimination': [2732], 'conformation': [2737, 2750], 'loop': [2740], 'regions,': [2741, 3402], 'II,': [2745], 'adopt': [2747], 'defined': [2749, 3433], 'when': [2751], 'connected': [2752], 'γ-phosphate.': [2755], 'number': [2761, 3389], 'different': [2763, 3087, 3321, 3392, 3589, 3755, 3760], 'effectors,': [2764], 'turn': [2767], 'regulate': [2768], 'directly,': [2773], 'mDia,': [2776, 3585], 'indirectly': [2778], 'modifying': [2780], 'activity': [2782, 3257], 'actin-binding': [2784], '46.Arai': [2799], 'Mabuchi': [2801], '115:': [2807], '887-898Crossref': [2808], '47.Bishop': [2812, 3156], 'A.L.': [2813, 2955, 3008, 3157, 3225], 'Hall': [2814, 2828, 2869, 2883, 2956, 2972, 3009, 3158, 3226], '2000;': [2818, 2960, 3013, 3162, 3230], '348:': [2819, 2961, 3014, 3163, 3231], '241-255Crossref': [2820, 2962, 3015, 3164, 3232], '(1682)': [2823, 2965, 3018, 3167, 3235], '48.Etienne-Manneville': [2826], '420:': [2832], '629-635Crossref': [2833], '(3875)': [2836], '49.Ho': [2839], 'H.Y.': [2840], 'Lebensohn': [2843], 'A.M.': [2844], 'Ma': [2845], 'L.': [2846, 3026, 3337, 3544], 'Gygi': [2849], 'S.P.': [2850], '118:': [2855], '203-216Abstract': [2856], '(353)': [2864], '50.Raftopoulou': [2867], 'Dev.': [2871, 3341], '265:': [2874], '23-32Crossref': [2875], '(1154)': [2878], '51.Ridley': [2881], 'A.J.': [2882], '1992;': [2886], '70:': [2887], '389-399Abstract': [2888], '(3843)': [2894], '52.Takai': [2897], 'Sasaki': [2899], 'Tanaka': [2901], 'Nakanishi': [2903], '1995;': [2908, 2977], '20:': [2909], '227-231Abstract': [2910], '(367)': [2916], '53.Wennerberg': [2919], 'Der': [2921], 'C.J.': [2922], '117:': [2927], '1301-1312Crossref': [2928], '(478)': [2931], 'motifs': [2935], 'effectors': [2938, 2948, 2992, 3125, 3393, 3427, 3568], 'divergent,': [2940], 'Cdc42/Rac-interactive': [2943, 3555], 'Cdc42/Rac': [2947], 'WASP,': [2949, 3220, 3561], 'WAVE,': [2950, 3221], 'ACK,': [2951], 'PAK': [2953], '(47.Bishop': [2954, 3007, 3224], '54.Burbelo': [2968], 'P.D.': [2969], 'Drechsel': [2970], '270:': [2978], '29071-29074Abstract': [2979], '(559)': [2987], 'Rhophilin,': [2993], 'Rhotekin,': [2994], 'kinase': [2997, 3210, 3743], 'N,': [2998, 3211], 'ROCK': [3000, 3443, 3521], 'bind': [3001, 3438], 'anti-parallel': [3004], '55.Jacobs': [3021], 'Hayakawa': [3023], 'Swenson': [3025], 'Bellon': [3027], 'Fleming': [3029], 'Taslimi': [3031], 'Doran': [3033], '281:': [3039], '260-268Abstract': [3040], '(209)': [3048], '56.Maesaki': [3051], 'Ihara': [3053], '4:': [3066], '793-803Abstract': [3067], '(139)': [3075], 'Scholar),': [3077, 3624], 'again': [3084], '(35.Rose': [3090, 4106], 'common': [3112], 'feature': [3113], 'recruit': [3123], 'particular': [3128, 3383], 'membrane': [3129], 'they': [3133], 'allosterically': [3135], 'activate': [3136], '(5.Buck': [3139], '57.Leung': [3170], 'D.W.': [3171], 'Proc.': [3174], 'Natl.': [3175], 'Acad.': [3176], '102:': [3182], '5685-5690Crossref': [3183], 'involves': [3190], 'intramolecular': [3195], 'autoinhibited': [3196], 'state': [3197], 'can': [3199], 'found': [3201], 'cases': [3204, 3939], 'kinases,': [3206], 'PAK,': [3213, 3560], 'case': [3218, 3583], 'autoinhibition': [3243], 'does': [3247], 'lead': [3249, 3328], 'full': [3251], 'catalyzed': [3258], 'plays': [3305], 'spatio-temporal': [3310], 'regulation': [3311], 'inside': [3316], 'cell.': [3318], 'Very': [3319], 'often,': [3320], 'signal': [3322], 'transduction': [3323], 'pathways': [3324], 'similar': [3330, 3790], 'cellular': [3333], 'responses': [3334], '(58.Van': [3335], 'Aelst': [3336], "D'Souza-Schorey": [3338], 'Gen.': [3340], '11:': [3343], '2295-2322Crossref': [3344], '(2101)': [3347], 'Effectors': [3350], 'nevertheless': [3355], 'promiscuous': [3357, 3633], 'responding': [3359], 'homologues,': [3365], 'i.e.': [3366], '-C,': [3369], 'such': [3378], 'TC10.': [3380], 'Because': [3381], 'plasticity': [3405], 'required': [3410], '(59.Dvorsky': [3411], 'Rep.': [3416], '12:': [3418], '1130-1136Crossref': [3419], '(125)': [3421], 'Numerous': [3424], 'have': [3428], 'so': [3431], 'far,': [3432], 'state.': [3442], 'Rhotekin': [3448], 'specifically': [3449, 3593], '(39.Watanabe': [3464, 3604], '60.Matsui': [3485], 'Amano': [3487], 'Chihara': [3491], 'Nakafuku': [3493], 'Ito': [3495], 'Nakano': [3497], 'Okawa': [3499], 'Iwamatsu': [3501], '1996;': [3507, 3548], '15:': [3508], '2208-2216Crossref': [3509], '(943)': [3512], 'postulated': [3518], 'residue': [3524], 'Glu-40': [3525], 'RhoA': [3527, 4292], 'discriminating': [3531], 'Cdc42,': [3534, 3638, 4359], 'Rac1': [3536, 4127, 4361], '(61.Leung': [3537], 'Chen': [3539], 'X.Q.': [3540], 'Manser': [3541], 'Lim': [3543], '5313-5327Crossref': [3550], 'containing': [3558, 3945, 4419, 4458], 'WAVE': [3563], 'specific': [3567, 3844], 'do': [3577], 'Rho.': [3581], 'In': [3582], 'situation': [3587], '-C': [3603], '-3': [3628], 'seem': [3629], 'RhoA-C,': [3637], 'RhoD': [3640], '(36.Watanabe': [3641], '62.Gasman': [3692], 'Kalaidzidis': [3694], 'Zerial': [3696], '5:': [3702], '195-204Crossref': [3703], '(178)': [3706], '63.Yasuda': [3709], 'Yonemura': [3717], 'Terada': [3719], '428:': [3727], '767-771Crossref': [3728], '(162)': [3731], 'question': [3735], 'ask': [3737], 'whether,': [3739], 'like': [3740, 4056], 'C-related': [3744], 'kinase,': [3745], 'multiple': [3750], 'sites': [3757], 'whether': [3759], 'use': [3763, 3788], 'same': [3765, 4134], 'site.': [3767], 'specificity': [3772, 3798, 3823], 'isoforms': [3777], 'proteins.': [3780, 4060], 'Rho,': [3784], 'Rac,': [3785], 'determined': [3800, 3825, 4067, 4089], 'Asn-Asn-Asn': [3803], '(triple': [3804], 'N)': [3805], 'replaced': [3811], 'Thr-Ser-His': [3813], '(TSH)': [3814], 'On': [3819], 'site,': [3822], 'Phe-His': [3828], 'substitution': [3829], 'Phe-106.': [3831], 'observe': [3834], 'first': [3837], 'time': [3838, 4383], 'helix,': [3842], 'hallmark': [3845], 'proteins,': [3848], 'Recombinant': [3856], 'Proteins—Proteins': [3857], 'were': [3858, 3872, 3880, 3916, 3955, 4044, 4054, 4066, 4088, 4130, 4139, 4182, 4204, 4217, 4246, 4269, 4348, 4365, 4390, 4414, 4496, 4557], 'expressed': [3859, 3873], 'glutathione': [3861, 4005], 'S-transferase': [3862, 4006], 'fusions': [3863], 'using': [3864, 4027, 4046, 4068, 4132, 4144, 4175, 4209, 4392, 4445, 4507, 4551], 'vector': [3866], 'pGEX-4T1': [3867], '(Amersham': [3868, 3967], 'Biosciences).': [3869], 'Escherichia': [3875], 'coli': [3876], 'BL21(DE3)': [3877], 'cells.': [3878], 'Cells': [3879, 3915, 3954], 'grown': [3881, 4415, 4497], 'A600': [3884], '0.7': [3886], '(37': [3887], '°C,': [3888], '160': [3889], 'rpm)': [3890], 'induced': [3892], '100': [3894, 3928, 3982, 4189, 4252, 4443, 4459, 4539], 'μm': [3895, 4444], 'isopropyl': [3896], 'β-d-thiogalactopyranoside': [3897], 'overnight': [3898, 4012], '20': [3900, 4142, 4355, 4462], '°C': [3901, 3909, 4143], 'mDiaN-TSH': [3905, 4034, 4065, 4370], '18': [3908], 'harvested': [3917], 'resuspended': [3919], 'buffer': [3921, 3975, 4025, 4272, 4352, 4417, 4456], '(20': [3923, 3977], 'mm': [3924, 3929, 3932, 3936, 3947, 3952, 3978, 3983, 3986, 3989, 4275, 4278, 4283, 4286, 4296, 4432, 4460, 4463, 4468, 4472], 'Tris/HCl,': [3925, 3979, 4279, 4464], 'pH': [3926, 3980, 4280, 4422, 4465], '7.5,': [3927, 3981, 4281, 4466], 'NaCl,': [3930, 3984, 4276, 4461], 'β-mercaptoethanol,': [3933, 3987, 4284, 4469], '5': [3935, 3988, 3997, 4285, 4295, 4471], 'MgCl2': [3937], 'Cdc42)': [3944], '0.1': [3946], 'phenylmethylsulfonyl': [3948], 'fluoride': [3949], 'EDTA.': [3953], 'lysed': [3956], 'microfluidizing;': [3958], 'extract': [3960], 'applied': [3962], 'GSH-Sepharose': [3965], 'column': [3966, 3971, 4011], 'Biosciences),': [3968], 'washed': [3973], 'B': [3976, 4026, 4353, 4457], 'MgCl2).': [3990], 'fusion': [3992, 4007], 'digested': [3995], 'units': [3998], 'thrombin': [4000], '(Serva)': [4001], 'per': [4002, 4376], 'mg': [4003], '4': [4014], '°C.': [4015, 4356], 'Final': [4016], 'purification': [4017], 'done': [4019, 4140, 4183, 4270, 4317], 'size': [4021, 4437, 4501], 'exclusion': [4022], 'chromatography': [4023], 'Superdex': [4029], 'S200': [4030], 'S75': [4036], 'Point': [4042], 'made': [4045], 'QuikChange': [4048], 'method': [4049], 'Stratagene.': [4051], 'Mutant': [4052], 'purified': [4055, 4096, 4131], 'type': [4059, 4198], 'Concentrations': [4061], 'absorption': [4070], '280': [4072], 'nm': [4073, 4162, 4190, 4253], 'under': [4074], 'denaturing': [4075], 'conditions': [4076], 'extinction': [4079], 'coefficient': [4080], 'deduced': [4081], 'sequence,': [4084], 'RhoA/Cdc42/Rac1': [4086, 4311], 'concentrations': [4087, 4195, 4480], 'Bradford': [4092], 'assay.': [4093], 'loaded': [4098], 'Gpp(NH)p': [4100], 'mant-Gpp(NH)p': [4102], 'elsewhere': [4105], 'strategy.': [4135], 'Stopped-flow': [4136], 'Kinetics—The': [4137], 'experiments': [4138, 4208, 4290], 'SX18': [4146], 'MW': [4147], 'Applied': [4148], 'Photophysics': [4149], 'apparatus': [4150], '(Leather-head,': [4151], 'UK).': [4152], 'mant': [4154], 'fluorophore': [4155], '(Molecular': [4156], 'Probes)': [4157], 'excited': [4159], '366': [4161], 'bandpass': [4165], '6.4': [4167], 'nm.': [4168], 'Emission': [4169], '(at': [4170], '450': [4171], 'nm)': [4172], 'recorded': [4174], '408-nm': [4177], 'cutoff': [4178], 'filter.': [4179], 'measurements': [4181, 4268, 4347], 'final': [4186, 4500], 'mant-Gpp(NH)p-loaded': [4191], 'GNBP/mutated': [4192], 'GNBP.': [4193], 'Increasing': [4194], '(1-15': [4202], 'μm)': [4203], 'pseudo': [4210], 'first-order': [4211], 'conditions.': [4212], 'observed': [4214, 4379], 'fluorescence': [4215], 'transients': [4216], 'fitted': [4218], 'single': [4221], 'exponential': [4222], 'function': [4223], 'obtain': [4225], 'kobs.': [4226], 'constant': [4230], 'kon': [4231], 'derived': [4233], 'slope': [4236], 'kobs': [4238], 'versus': [4239], 'concentration.': [4241], 'dissociation': [4243], 'constants': [4245], 'obtained': [4247], 'mixing': [4249], 'preformed': [4251], 'mDiaN·RhoA·mant-Gpp(NH)p': [4254], '(or': [4255, 4362], 'mutated': [4256], '100-fold': [4261], 'excess': [4262], 'unlabeled': [4264], 'protein.': [4266], 'C': [4273], '(300': [4274], '50': [4277], 'MgCl2),': [4287], 'additionally': [4293], 'contained': [4294], 'MgCl2.': [4297], 'GraFit': [4298], '3.0-5.0': [4299], 'data': [4303, 4389, 4580], 'analysis.': [4304], 'ITC': [4305, 4319], 'Measurements—The': [4306], 'mDiaN/mDiaN-TSH': [4309], 'DAD-(1145-1200)': [4313], 'mutants': [4315], 'Wiseman': [4322], 'et': [4323], 'al.': [4324], '(64.Wiseman': [4325], 'Williston': [4327], 'Brandts': [4329], 'J.F.': [4330], 'Lin': [4331], 'L.N.': [4332], 'Anal.': [4333], '179:': [4336], '131-137Crossref': [4337], '(2447)': [4340], 'Scholar)': [4342], '(MicroCal™;': [4343], 'VP-ITC': [4344], 'MicroCalorimeter).': [4345], 'carried': [4349], 'out': [4350], 'mutants)': [4363], '(syringe)': [4364], 'stepwise-injected': [4366], 'solution': [4371, 4477, 4509], '(cell).': [4372], 'heating': [4374], 'power': [4375], 'injection': [4377], 'over': [4380], 'reaction': [4382], 'until': [4384], 'equilibrium': [4385], 'reached.': [4387], 'software': [4394], 'provided': [4395], 'manufacturer.': [4398], 'Crystallization,': [4399], 'Collection,': [4401], 'Solution—Crystals': [4404], 'mDiaN[TSH]': [4407], '(69-451)': [4409], 'Cdc42-(1-178)·Gpp(NH)p': [4413], 'D': [4418], '8.8': [4423], '(pH': [4424], 'adjusted': [4425], 'citric': [4427], 'acid),': [4428], '26%': [4429], 'PEG3350,': [4430], '250': [4431], 'sodium': [4433], 'tartrate': [4434], '∼100': [4439], '×': [4440, 4442], '200': [4441], 'hanging': [4447], 'drop/vapor': [4448], 'diffusion': [4449], 'method.': [4450], 'solved': [4454], 'MgCl2.1': [4473], 'μl': [4474], 'various': [4479], '(2.5,': [4481], '5,': [4482], '10': [4484], 'μg/μl)': [4485], 'mixed': [4487], 'reservoir': [4490, 4508], 'solution.': [4491], 'After': [4492], 'day': [4494], 'crystals': [4495], 'flash-frozen': [4503], 'liquid': [4505], 'nitrogen': [4506], '35%': [4511], 'PEG3350': [4512], 'cryoprotectant.': [4514], 'set': [4516], 'collection': [4517], 'performed': [4520], 'Swiss': [4523], 'Light': [4524], 'Source,': [4525], 'Paul': [4526], 'Scherrer': [4527], 'Institut,': [4528], 'Villigen,': [4529], 'Switzerland': [4530], '(Table': [4531], '4).': [4532], 'native': [4534], 'dataset': [4535], 'collected': [4537], 'K': [4540], 'beam': [4542], 'line': [4543], 'PXII': [4544], 'wavelength': [4547], '0.95': [4549], 'Å': [4550], 'Mar225': [4553], 'CCD': [4554], 'detector.': [4555], 'indexed,': [4558], 'integrated,': [4559], 'scaled': [4561], 'XDS': [4564], 'package': [4565], '(65.Kabsch': [4566], 'Appl.': [4569], '1993;': [4571], '26:': [4572], '795-800Crossref': [4573], '(3243)': [4575], 'Scholar).TABLE': [4577], '4Statistics': [4578], 'coll': [4581]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056211908', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-14T20:33:30.602929', 'created_date': '2016-06-24'}
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