Title: Synthesis of some cyano-, amino- and carboxyborane adducts of amines and diamines
Abstract: The amine- and diamine-cyanoboranes, amine·nBH2CN (n = 1, amine = O(CH2CH2)2NMe and Me2NCH2CH2CN; n = 2, amine = Me2NCH2CH2NMe2 and H2NCH2CH2NH2) were prepared from the amine hydrochlorides and NaBH3CN. New amine- and diamine-carboxyboranes, amine·nBH2COOH(n = 1, amine = C5H5N and O(CH2CH2)2NMe; n = 2, amine = Me2NCH2CH2NMe2) were prepared by alkylation of the corresponding amine-cyanoborane with Et3OBF4 to the N-ethylnitrilium salts and subsequent reaction with water. In one case hydrolysis with NaOH resulted in the bis (N-ethylamidoborane), (Me2NCH2CH2NMe2)·2BH2C(O)NHEt. Preliminary results of studies of antitumor, and hypocholesterolemic activity in mice of several of these compounds are reported.
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 30
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