Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2056203655', 'doi': 'https://doi.org/10.1021/bm3017324', 'title': 'Intracellular Drug Release from Curcumin-Loaded PLGA Nanoparticles Induces G2/M Block in Breast Cancer Cells', 'display_name': 'Intracellular Drug Release from Curcumin-Loaded PLGA Nanoparticles Induces G2/M Block in Breast Cancer Cells', 'publication_year': 2013, 'publication_date': '2013-01-27', 'ids': {'openalex': 'https://openalex.org/W2056203655', 'doi': 'https://doi.org/10.1021/bm3017324', 'mag': '2056203655', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23350530'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bm3017324', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S11629336', 'display_name': 'Biomacromolecules', 'issn_l': '1525-7797', 'issn': ['1525-7797', '1526-4602'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011668568', 'display_name': 'Paolo Verderio', 'orcid': 'https://orcid.org/0000-0002-9231-1281'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paolo Verderio', 'raw_affiliation_strings': ["Dipartimento di Biotecnologie e Bioscienze, Universita' di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy"], 'affiliations': [{'raw_affiliation_string': "Dipartimento di Biotecnologie e Bioscienze, Universita' di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy", 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013343695', 'display_name': 'Paolo Bonetti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087773', 'display_name': 'Luigi Sacco Hospital', 'ror': 'https://ror.org/0025g8755', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087773', 'https://openalex.org/I4210156709']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paolo Bonetti', 'raw_affiliation_strings': ['Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'institution_ids': ['https://openalex.org/I4210087773']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011206324', 'display_name': 'Miriam Colombo', 'orcid': 'https://orcid.org/0000-0003-3428-5668'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}, {'id': 'https://openalex.org/I4210087773', 'display_name': 'Luigi Sacco Hospital', 'ror': 'https://ror.org/0025g8755', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087773', 'https://openalex.org/I4210156709']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Miriam Colombo', 'raw_affiliation_strings': ['Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'Dipartimento di\rBiotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, 20126 Milano,\rItaly'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di\rBiotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, 20126 Milano,\rItaly', 'institution_ids': ['https://openalex.org/I66752286']}, {'raw_affiliation_string': 'Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'institution_ids': ['https://openalex.org/I4210087773']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088698720', 'display_name': 'Laura Pandolfi', 'orcid': 'https://orcid.org/0000-0003-0485-7901'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}, {'id': 'https://openalex.org/I4210087773', 'display_name': 'Luigi Sacco Hospital', 'ror': 'https://ror.org/0025g8755', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087773', 'https://openalex.org/I4210156709']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Pandolfi', 'raw_affiliation_strings': ['Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'Dipartimento di\rBiotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, 20126 Milano,\rItaly'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di\rBiotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, 20126 Milano,\rItaly', 'institution_ids': ['https://openalex.org/I66752286']}, {'raw_affiliation_string': 'Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'institution_ids': ['https://openalex.org/I4210087773']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028842822', 'display_name': 'Davide Prosperi', 'orcid': 'https://orcid.org/0000-0003-4577-9575'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}, {'id': 'https://openalex.org/I4210087773', 'display_name': 'Luigi Sacco Hospital', 'ror': 'https://ror.org/0025g8755', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087773', 'https://openalex.org/I4210156709']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Davide Prosperi', 'raw_affiliation_strings': ['Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'Dipartimento di\rBiotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, 20126 Milano,\rItaly'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di\rBiotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, 20126 Milano,\rItaly', 'institution_ids': ['https://openalex.org/I66752286']}, {'raw_affiliation_string': 'Dipartimento\rdi Scienze\rBiomediche e Cliniche “Luigi Sacco”, Università di Milano, Ospedale L. Sacco, via\rG.B. Grassi 74, 20157 Milano, Italy', 'institution_ids': ['https://openalex.org/I4210087773']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.496, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 149, 'citation_normalized_percentile': {'value': 0.99956, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '14', 'issue': '3', 'first_page': '672', 'last_page': '682'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10920', 'display_name': 'Advanced Drug Delivery Systems', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/plga', 'display_name': 'PLGA', 'score': 0.8102249}], 'concepts': [{'id': 'https://openalex.org/C2778250585', 'wikidata': 'https://www.wikidata.org/wiki/Q312266', 'display_name': 'Curcumin', 'level': 2, 'score': 0.86082816}, {'id': 'https://openalex.org/C2780165375', 'wikidata': 'https://www.wikidata.org/wiki/Q2102907', 'display_name': 'PLGA', 'level': 3, 'score': 0.8102249}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6194895}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.59931934}, {'id': 'https://openalex.org/C155672457', 'wikidata': 'https://www.wikidata.org/wiki/Q61231', 'display_name': 'Nanoparticle', 'level': 2, 'score': 0.5287116}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.50280595}, {'id': 'https://openalex.org/C2779178360', 'wikidata': 'https://www.wikidata.org/wiki/Q902045', 'display_name': 'Confocal microscopy', 'level': 2, 'score': 0.49259692}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.45145524}, {'id': 'https://openalex.org/C14631669', 'wikidata': 'https://www.wikidata.org/wiki/Q896108', 'display_name': 'Dynamic light scattering', 'level': 3, 'score': 0.4203751}, {'id': 'https://openalex.org/C163588942', 'wikidata': 'https://www.wikidata.org/wiki/Q5165929', 'display_name': 'Controlled release', 'level': 2, 'score': 0.41551295}, {'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.4121849}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.32673788}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.2828198}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.24205968}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.19931668}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15528724}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.11438179}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.08258283}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D019344', 'descriptor_name': 'Lactic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D053758', 'descriptor_name': 'Nanoparticles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011100', 'descriptor_name': 'Polyglycolic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001682', 'descriptor_name': 'Biological Availability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059447', 'descriptor_name': 'Cell Cycle Checkpoints', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D059447', 'descriptor_name': 'Cell Cycle Checkpoints', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019344', 'descriptor_name': 'Lactic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053758', 'descriptor_name': 'Nanoparticles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010316', 'descriptor_name': 'Particle Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011100', 'descriptor_name': 'Polyglycolic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077182', 'descriptor_name': 'Polylactic Acid-Polyglycolic Acid Copolymer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bm3017324', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S11629336', 'display_name': 'Biomacromolecules', 'issn_l': '1525-7797', 'issn': ['1525-7797', '1526-4602'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23350530', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.82, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W125106425', 'https://openalex.org/W1892905988', 'https://openalex.org/W1972179974', 'https://openalex.org/W1973509266', 'https://openalex.org/W1975770667', 'https://openalex.org/W1976194786', 'https://openalex.org/W1986826942', 'https://openalex.org/W1987029887', 'https://openalex.org/W1988652094', 'https://openalex.org/W1989905268', 'https://openalex.org/W1990351531', 'https://openalex.org/W1992015481', 'https://openalex.org/W1995997034', 'https://openalex.org/W2001964336', 'https://openalex.org/W2016652483', 'https://openalex.org/W2020398834', 'https://openalex.org/W2025187028', 'https://openalex.org/W2028556682', 'https://openalex.org/W2035155408', 'https://openalex.org/W2039464784', 'https://openalex.org/W2043605108', 'https://openalex.org/W2046574646', 'https://openalex.org/W2055928970', 'https://openalex.org/W2070878775', 'https://openalex.org/W2072175441', 'https://openalex.org/W2076008642', 'https://openalex.org/W2085711772', 'https://openalex.org/W2088242076', 'https://openalex.org/W2091246708', 'https://openalex.org/W2109408781', 'https://openalex.org/W2109773265', 'https://openalex.org/W2115439624', 'https://openalex.org/W2118935736', 'https://openalex.org/W2120826143', 'https://openalex.org/W2121166735', 'https://openalex.org/W2124955356', 'https://openalex.org/W2127457668', 'https://openalex.org/W2127913359', 'https://openalex.org/W2132870913', 'https://openalex.org/W2137407924', 'https://openalex.org/W2139144983', 'https://openalex.org/W2141515673', 'https://openalex.org/W2144491599', 'https://openalex.org/W2156156861', 'https://openalex.org/W2238003553', 'https://openalex.org/W4240479615'], 'related_works': ['https://openalex.org/W3161252477', 'https://openalex.org/W3017451270', 'https://openalex.org/W2792441275', 'https://openalex.org/W2791169112', 'https://openalex.org/W2161308872', 'https://openalex.org/W2157156553', 'https://openalex.org/W2033391661', 'https://openalex.org/W2026991737', 'https://openalex.org/W2011155894', 'https://openalex.org/W1988208400'], 'abstract_inverted_index': {'PLGA': [0, 44, 64, 94, 99, 180], 'nanoparticles': [1, 45, 65, 126, 181], 'are': [2], 'among': [3], 'the': [4, 28, 118, 122, 144, 151, 196, 203], 'most': [5], 'studied': [6], 'polymer': [7], 'nanoformulations': [8], 'for': [9, 202], 'several': [10], 'drugs': [11], 'against': [12], 'different': [13], 'kinds': [14], 'of': [15, 83, 89, 104, 125, 153, 155, 171, 191, 200, 205], 'malignant': [16, 207], 'diseases,': [17], 'thanks': [18], 'to': [19, 120, 183, 194], 'their': [20], 'in': [21, 62, 70, 92, 143], 'vivo': [22], 'stability': [23], 'and': [24, 32, 175], 'tumor': [25], 'localization': [26], 'exploiting': [27], 'well-documented': [29], '"enhanced': [30], 'permeation': [31], 'retention"': [33], '(EPR)': [34], 'effect.': [35], 'In': [36], 'this': [37, 192], 'paper,': [38], 'we': [39, 115], 'have': [40, 116], 'developed': [41], 'uniform': [42], 'curcumin-bearing': [43], 'by': [46, 74, 110, 140], 'a': [47, 52, 56, 79, 129, 188], 'single-emulsion': [48], 'process,': [49], 'which': [50, 146], 'exhibited': [51], 'curcumin': [53, 105, 141, 201], 'release': [54, 142], 'following': [55], 'Fickian-law': [57], 'diffusion': [58], 'over': [59], '10': [60], 'days': [61], 'vitro.': [63], 'were': [66], 'about': [67], '120': [68], 'nm': [69], 'size,': [71], 'as': [72, 108], 'determined': [73, 109], 'dynamic': [75], 'light': [76], 'scattering,': [77], 'with': [78, 128], 'surface': [80], 'negative': [81], 'charge': [82], '-30': [84], 'mV.': [85], 'The': [86], 'loading': [87], 'ratio': [88], 'encapsulated': [90], 'drug': [91], 'our': [93, 156], 'nanoformulation': [95], 'was': [96, 160], '8': [97], 'wt%.': [98], 'encapsulation': [100], 'provided': [101, 147], 'efficient': [102], 'protection': [103], 'from': [106], 'environment,': [107], 'fluorescence': [111], 'emission': [112], 'experiments.': [113], 'Next,': [114], 'investigated': [117], 'possibility': [119], 'study': [121, 159], 'intracellular': [123], 'degradation': [124], 'associated': [127], 'specific': [130], 'G2/M': [131], 'blocking': [132], 'effect': [133], 'on': [134, 150], 'MCF7': [135], 'breast': [136, 208], 'cancer': [137], 'cells': [138], 'caused': [139], 'cytoplasm,': [145], 'direct': [148], 'evidence': [149], 'mechanism': [152], 'action': [154], 'nanocomplex.': [157], 'This': [158], 'carried': [161], 'out': [162], 'using': [163], 'Annexin': [164], 'V-based': [165], 'cell': [166], 'death': [167], 'analysis,': [168], 'MTT': [169], 'assessment': [170], 'proliferation,': [172], 'flow': [173], 'cytometry,': [174], 'confocal': [176], 'laser': [177], 'scanning': [178], 'microscopy.': [179], 'proved': [182], 'be': [184], 'completely': [185], 'safe,': [186], 'suggesting': [187], 'potential': [189], 'utilization': [190], 'nanocomplex': [193], 'improve': [195], 'intrinsically': [197], 'poor': [198], 'bioavailability': [199], 'treatment': [204], 'severe': [206], 'cancer.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056203655', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 9}], 'updated_date': '2024-12-29T19:30:37.274182', 'created_date': '2016-06-24'}