Publication Information

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1242, 1641, 1948, 3367], 'kinase,': [3, 227], 'c-Jun': [4, 228, 510, 562], 'N-terminal': [5, 229, 511, 563], 'kinase': [6, 60, 61, 230, 284, 285, 526, 527, 578, 579, 618, 670, 1243, 1642, 1643], '(JNK),': [7, 231], 'has': [8, 232, 805, 1085], 'been': [9, 233, 806, 988, 1086, 1535, 3080], 'implicated': [10, 234, 785], 'in': [11, 25, 37, 65, 140, 182, 189, 202, 212, 218, 235, 249, 261, 289, 364, 406, 413, 426, 436, 442, 458, 477, 648, 700, 808, 972, 991, 999, 1150, 1166, 1172, 1184, 1328, 1369, 1438, 1457, 1477, 1488, 1493, 1505, 1742, 1943, 1959, 2258, 2266, 2275, 2531, 2613, 3268, 3271, 3280, 3330, 3371, 3398, 3464, 3545, 3565, 3572, 3581, 3591, 3613, 3623, 3626, 3637, 3649, 3775, 3887, 3893, 3965, 4138, 4148, 4163, 4212, 4221, 4236, 4245], 'the': [12, 20, 32, 78, 112, 164, 195, 219, 236, 244, 256, 302, 336, 388, 419, 443, 487, 613, 675, 682, 691, 695, 976, 994, 1027, 1067, 1126, 1137, 1151, 1163, 1365, 1468, 1528, 1635, 1655, 1689, 1755, 1762, 1765, 1854, 2008, 2080, 2101, 2111, 2204, 2207, 2227, 2231, 2267, 2341, 2469, 2539, 2757, 2965, 3095, 3109, 3194, 3331, 3391, 3470, 3529, 3578, 3638, 3826], 'process': [13, 237, 457, 489], 'of': [14, 23, 34, 54, 77, 94, 105, 114, 122, 127, 155, 168, 185, 198, 215, 221, 238, 247, 258, 278, 301, 318, 329, 338, 346, 351, 379, 392, 409, 422, 439, 445, 450, 486, 612, 620, 630, 677, 684, 705, 792, 963, 978, 996, 1002, 1020, 1026, 1059, 1066, 1128, 1140, 1143, 1162, 1321, 1461, 1467, 1480, 1509, 1517, 1521, 1531, 1764, 1853, 1922, 2071, 2163, 2199, 2206, 2230, 2326, 2330, 2352, 2355, 2389, 2422, 2473, 2582, 2742, 2810, 2949, 2952, 2977, 3086, 3121, 3196, 3253, 3266, 3278, 3327, 3336, 3347, 3393, 3403, 3419, 3440, 3449, 3486, 3556, 3562, 3587, 3621, 3633, 3640, 3781, 3801, 3834, 3838, 3847, 3850, 3857, 3885, 3906, 3928, 3932, 3946, 4049, 4114, 4144, 4159, 4167, 4179, 4204, 4209], 'cardiac': [15, 200, 216, 222, 239, 424, 440, 446, 794, 809, 973, 982, 1003, 1022, 1180, 1440, 1815, 2673, 3185], 'hypertrophy': [16, 240, 465, 810, 1453, 3518, 3642], 'and': [17, 82, 159, 176, 204, 241, 306, 383, 400, 428, 480, 633, 645, 681, 713, 796, 929, 984, 993, 1084, 1135, 1281, 1363, 1431, 1472, 1484, 1527, 1647, 1697, 1738, 1807, 1857, 1907, 1912, 1925, 1931, 1940, 1957, 1992, 2017, 2032, 2052, 2059, 2066, 2073, 2089, 2217, 2243, 2273, 2277, 2283, 2298, 2333, 2377, 2391, 2424, 2482, 2491, 2537, 2569, 2580, 2606, 2654, 2667, 2735, 2747, 2801, 2813, 2815, 2826, 2879, 2916, 2970, 3059, 3100, 3132, 3182, 3201, 3325, 3352, 3381, 3386, 3433, 3452, 3519, 3528, 3585, 3598, 3646, 3786, 3803, 3841, 3862, 3908, 3935, 3941, 4171, 4201, 4231], 'apoptosis,': [18, 242], 'yet': [19, 243, 975], 'specific': [21, 115, 153, 175, 213, 245, 339, 377, 399, 437, 484, 1018, 1507, 2063, 3004], 'roles': [22, 246], 'JNK': [24, 35, 73, 149, 210, 248, 259, 297, 373, 434, 504, 697, 786, 803, 959, 970, 979, 997, 1014, 1164, 1337, 1446, 1462, 1498, 2058, 3267, 3279, 3366, 3397, 3548, 3605, 3622], 'heart': [26, 96, 250, 320, 451, 797, 1006, 1069, 1167, 1370, 1514, 2103, 2285, 3421, 3520, 3567, 3635, 3916], 'failure': [27, 251, 452, 1007, 3521, 3636], 'are': [28, 252, 625, 2062, 2599, 2883], 'unclear.': [29, 253, 1009], 'To': [30, 254, 1222, 1946, 3540], 'determine': [31, 255], 'effects': [33, 257, 977, 1139], 'activation': [36, 150, 260, 374, 676, 980, 1015, 1161, 1447, 1460, 3197, 3277, 3346, 3402, 3606, 3620], 'intact': [38, 262, 1152, 4213], 'heart,': [39, 263, 696], 'we': [40, 146, 264, 370, 1124, 1226, 1234, 3388], 'established': [41, 265, 990, 1741, 3284], 'transgenic': [42, 266, 1157, 1175, 1850, 2656, 2812, 3273, 3318, 3442, 3783, 3889, 4169], 'animals': [43, 86, 267, 310, 1158, 1687, 2208, 2616, 2738, 4214], 'using': [44, 268, 961, 1917, 2079, 2091, 2105, 2160, 2337, 2382, 2395, 2433, 2504, 2527, 2560, 2751, 2823, 2838, 2922, 2964, 2992, 3094, 3108, 3285], 'a': [45, 102, 134, 269, 326, 358, 454, 610, 628, 703, 789, 1017, 1063, 1228, 1323, 1425, 1478, 1485, 1502, 1743, 1993, 2013, 2161, 2239, 2302, 2309, 2383, 2483, 2508, 2575, 2592, 2752, 3250, 3286, 3334, 3361, 3461, 3776, 3920, 4139, 4234, 4242], 'Cre/loxP-mediated': [46, 270, 1229, 3287], 'gene': [47, 80, 271, 304, 1230, 1756, 2978, 3288], 'switch': [48, 272, 1231, 3289, 3537], 'approach': [49, 273, 3290], 'to': [50, 71, 152, 274, 295, 376, 460, 466, 483, 674, 690, 702, 1016, 1088, 1091, 1155, 1178, 1238, 1318, 1423, 1435, 1451, 1464, 1649, 2026, 2029, 2086, 2110, 2294, 2462, 3092, 3184, 3198, 3256, 3345, 3478, 3532, 3547, 3570, 3610, 3629, 3815, 3869], 'achieve': [51, 275], 'targeted': [52, 276, 1160, 3276], 'expression': [53, 69, 120, 165, 277, 293, 344, 389, 1145, 1320, 2979, 3324, 3329, 3343], 'an': [55, 206, 279, 430, 474, 955, 1522, 2528, 2829, 3447, 4185], 'upstream': [56, 280], 'activator,': [57, 281], 'mitogen-activated': [58, 282, 524, 576, 616, 1241, 1640], '7': [62, 286, 528, 580], '(D)': [63, 287], '(MKK7D),': [64, 288], 'ventricular': [66, 186, 290, 410, 1329, 1481, 2435, 3281, 3465, 3487, 3624, 3641, 4052, 4064, 4117, 4126, 4237, 4246], 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[99, 323], 'echocardiography': [100, 324, 4225], 'revealed': [101, 125, 325, 349], 'marked': [103, 327], 'stiffening': [104, 328], 'JNK-activated': [106, 190, 330, 414, 3490, 3566, 3782, 4149, 4205, 4210], 'hearts': [107, 124, 331, 348, 1935, 2205, 2336, 2820, 3373, 3443, 3491, 3593, 3788, 3938, 4211], 'that': [108, 148, 332, 372, 624, 1182, 1445, 1475, 1497, 2225, 3571, 3604, 3619], 'was': [109, 333, 1652, 2118, 2209, 2317, 2346, 2393, 2431, 2457, 2525, 2572, 2836, 2962, 2980, 3171, 3191, 3206, 3241, 3283, 3444, 3472, 3492, 3552, 3568, 4215], 'associated': [110, 334, 1512, 3516], 'remodeling': [113, 180, 217, 337, 404, 441, 456, 488, 795, 1004, 1132, 1466, 1511, 4147], 'extracellular': [116, 141, 340, 365, 517, 535, 569, 587, 1469, 4145], 'matrix': [117, 142, 341, 366, 1470, 4146], 'components.': [118, 342], 'Gene': [119, 343], 'analysis': [121, 345, 1427, 2117, 3849], 'up-regulation': [126, 350], 'transforming': [128, 352, 545, 597, 3006], 'growth': [129, 353, 546, 598, 3007], 'factor': [130, 354, 3008], 'β': [131, 355], 'signaling,': [132, 356], 'offering': [133, 357], 'potential': [135, 359, 550, 602, 1148, 3188, 3203], 'molecular': [136, 360], 'mechanism': [137, 361], 'underlying': [138, 362], 'changes': [139, 363, 3631], 'composition.': [143, 367], 'In': [144, 368, 694, 1121], 'addition,': [145, 369], 'demonstrated': [147, 371, 807, 954, 1087, 1136, 1444, 3390], 'loss': [154, 378, 962, 1142, 1479], 'connexin': [156, 380, 514, 566, 1031], '43': [157, 381, 1032], 'gap': [160, 178, 384, 402, 1028, 1060, 1473], 'junctions': [161, 385, 1061, 1474], 'without': [162, 386, 3400], 'affecting': [163, 387], 'or': [166, 390, 1454, 2477, 3405, 3643], 'localization': [167, 391], 'other': [169, 393], 'key': [170, 394, 790], 'intercalated': [171, 395, 1130], 'disc': [172, 396, 1131], 'proteins.': [173, 397], 'This': [174, 398, 1417, 1492], 'localized': [177, 401], 'junction': [179, 403, 1029], 'resulted': [181, 405, 1183], 'slowing': [184, 408], 'electrical': [187, 411], 'conduction': [188, 412, 1490], 'hearts.': [191, 415, 3784, 3844, 3890, 4150], 'These': [192, 416, 2057, 3601], 'results': [193, 417, 1443, 1476, 3602, 3942], 'represent': [194, 418], 'first': [196, 420], 'characterization': [197, 421], 'JNK-mediated': [199, 423], 'pathology': [201, 425], 'vivo': [203, 427, 1494, 3399, 3627], 'support': [205, 429], 'important': [207, 431, 475, 686, 800], 'role': [208, 432, 476, 801, 957, 995, 1504], 'for': [209, 433, 687, 802, 958, 1133, 1758, 2064, 2328, 2520, 2550, 2586, 2663, 3000, 3005, 3114, 3124, 3129, 3135, 3208, 3395], 'signaling': [211, 435, 471, 622, 787, 804, 960, 971, 998, 1499], 'aspects': [214, 438, 1001, 1508], 'pathogenesis': [220, 444], 'disease.': [223, 447], 'development': [449], 'involves': [453], 'multistep': [455], 'response': [459, 679, 701, 3546], 'pathological': [461, 706, 793, 1021, 1510], 'stressors,': [462], 'from': [463, 1864, 1938, 2100, 2203, 2319, 2322, 2730, 2807, 2956, 3178, 3489, 3830, 3836, 3854, 3924, 3930, 4229], 'compensatory': [464], 'decompensated': [467], 'chamber': [468, 4238], 'remodeling.': [469], 'Stress-induced': [470], 'pathways': [472], 'play': [473, 1501], 'these': [478], 'responses': [479], 'may': [481, 1500], 'contribute': [482, 1089], 'features': [485], '(1Sugden': [490], 'P.H.': [491, 751], 'Clerk': [492], 'A.': [493, 747, 765, 848, 878, 1249, 1272, 1346, 1398, 1567, 1590, 1706, 1729, 1875, 1898, 2128, 2151, 2187, 2629, 2768, 2791, 3033], 'Circ.': [494, 752, 1048, 1074, 1111, 1552, 2445, 2689, 3307], 'Res.': [495, 753, 772, 1049, 1075, 1112, 1553, 2446, 2690, 2864, 2906, 3160, 3308], '1998;': [496, 774, 826, 854, 1673, 1791], '83:': [497], '345-352Crossref': [498], 'PubMed': [499, 661, 731, 757, 777, 834, 857, 887, 922, 948, 1053, 1079, 1116, 1217, 1276, 1313, 1356, 1388, 1412, 1557, 1594, 1629, 1681, 1733, 1799, 1839, 1902, 2155, 2191, 2372, 2450, 2646, 2694, 2721, 2795, 2942, 3023, 3054, 3076, 3164, 3226, 3312], 'Scopus': [500, 662, 732, 758, 778, 835, 858, 888, 923, 949, 1054, 1080, 1117, 1218, 1277, 1314, 1357, 1389, 1413, 1558, 1595, 1630, 1682, 1734, 1800, 1840, 1903, 2156, 2192, 2373, 2451, 2647, 2695, 2722, 2796, 2943, 3024, 3055, 3165, 3227, 3313], '(440)': [501], 'Google': [502, 664, 734, 760, 780, 837, 860, 890, 925, 951, 1056, 1082, 1119, 1220, 1279, 1316, 1359, 1391, 1415, 1560, 1597, 1632, 1684, 1736, 1802, 1842, 1905, 2158, 2194, 2375, 2418, 2453, 2649, 2697, 2724, 2798, 2868, 2910, 2945, 3026, 3057, 3077, 3167, 3229, 3315], 'Scholar).': [503, 665, 781, 926, 1057, 1120, 1221, 1416, 1633, 1685, 1803, 1843, 2195, 2419, 2454, 2650, 2725, 2799, 2869, 2911, 2946, 3168, 3230, 3316], '1The': [505, 557], 'abbreviations': [506, 558], 'used': [507, 559, 1236, 2999, 3814], 'are:': [508, 560], 'JNK,': [509, 561, 2051, 2068], 'kinase;': [512, 537, 564, 589], 'Cx43,': [513, 565], '43;': [515, 567], 'ECM,': [516, 568], 'matrix;': [518, 570], 'GFP,': [519, 571], 'green': [520, 572], 'fluorescent': [521, 573, 3912], 'protein;': [522, 574], 'MKK7D,': [523, 575, 1322], '(D);': [529, 581], 'MLC,': [530, 582], 'myosin': [531, 583, 1766], 'light': [532, 584, 1767], 'chain;': [533, 585], 'ERK,': [534, 586, 2049, 3387], 'signal-regulated': [536, 588], 'GAPDH,': [538, 590], 'glyceraldehyde-3-phosphate': [539, 591], 'dehydrogenase;': [540, 592], 'RT,': [541, 593], 'reverse': [542, 594, 3102], 'transcriptase;': [543, 595], 'TGF,': [544, 596], 'factor;': [547, 599], 'APD,': [548, 600], 'action': [549, 601, 1147, 3202], 'duration;': [551, 603], 'TUNEL,': [552, 604], 'terminal': [553, 605], 'dUTP': [554, 606], 'nick-end': [555, 607], 'labeling.': [556, 608], 'is': [609, 698, 1062, 1448, 3607, 3825], 'member': [611], 'highly': [614, 1366], 'conserved': [615], 'family': [619, 671], 'intracellular': [621], 'molecules': [623], 'activated': [626, 699], 'by': [627, 668, 1170, 1694, 1862, 2263, 2340, 2348, 2379, 2489, 2885, 2891, 2982, 3090, 3118, 3173, 3243, 3263, 3358, 3446, 3896, 4155, 4217], 'variety': [629, 704], 'physical,': [631], 'chemical,': [632], 'biological': [634], 'stressors': [635], 'such': [636, 708, 1224], 'as': [637, 709, 788, 892, 894, 1699, 1867, 1928, 2120, 2246, 2359, 2399, 2426, 2428, 2437, 2517, 2554, 2601, 2622, 2661, 2760, 2848, 2889, 2959, 3144, 3193, 3211, 3235, 3291, 3333, 3356, 3919, 3944], 'ultraviolet': [638], 'radiation,': [639], 'heat': [640], 'shock,': [641], 'osmotic': [642], 'stress,': [643], 'cytokines,': [644], 'endotoxins': [646], '(reviewed': [647], 'Ref.': [649], '2Davis': [650], 'R.J.': [651, 1071, 2440], 'Cell.': [652], '2000;': [653, 728, 1214, 1353, 2415], '103:': [654], '239-252Abstract': [655], 'Full': [656, 658, 829, 831, 917, 919, 1676, 1678, 1794, 1796, 1834, 1836, 2716, 2718], 'Text': [657, 659, 830, 832, 918, 920, 1677, 1679, 1795, 1797, 1835, 1837, 2717, 2719], 'PDF': [660, 833, 921, 1680, 1798, 1838, 2720], '(3611)': [663], 'Signals': [666, 2076], 'transduced': [667], 'this': [669, 1122], 'ultimately': [672], 'lead': [673], 'stress': [678, 692], 'genes': [680, 3515], 'synthesis': [683], 'proteins': [685], 'cellular': [688], 'adaptation': [689], 'stimulus.': [693], 'insults': [707], 'hypertension,': [710], 'ischemia/reperfusion': [711], 'injury,': [712], 'myocardial': [714, 1465], 'infarction': [715], '(3Pellieux': [716], 'C.': [717, 2631], 'Sauthier': [718], 'T.': [719, 725, 850, 880, 906, 1396], 'Aubert': [720], 'J.F.': [721], 'Brunner': [722], 'H.R.': [723], 'Pedrazzini': [724], 'J.': [726, 739, 820, 823, 851, 881, 902, 911, 944, 1104, 1213, 1257, 1297, 1300, 1308, 1352, 1384, 1400, 1408, 1575, 1613, 1616, 1624, 1667, 1670, 1714, 1772, 1785, 1788, 1823, 1827, 1828, 1883, 2136, 2366, 2413, 2640, 2705, 2709, 2710, 2776, 3046, 3220], 'Hypertens.': [727], '18:': [729], '1307-1317Crossref': [730], '(44)': [733], 'Scholar,': [735, 761, 838, 861, 1392, 1561, 1598, 2698], '4Bogoyevitch': [736], 'M.A.': [737], 'Gillespie-Brown': [738], 'Ketterman': [740], 'A.J.': [741, 2639], 'Fuller': [742], 'S.J.': [743], 'Ben-Levy': [744], 'R.': [745, 842, 865, 1199, 1406, 1782], 'Ashworth': [746], 'Marshall': [748], 'C.J.': [749], 'Sugden': [750], '1996;': [754, 1409, 3020, 3223], '79:': [755], '162-173Crossref': [756], '(488)': [759], '5Li': [762], 'W.G.': [763], 'Zaheer': [764], 'Coppey': [766], 'L.': [767], 'Oskarsson': [768], 'H.J.': [769], 'Biochem.': [770, 1351, 3017], 'Biophys.': [771], 'Commun.': [773], '246:': [775], '816-820Crossref': [776], '(46)': [779], 'Several': [782], 'studies': [783], 'have': [784, 986, 1011, 1534, 1811, 2670, 3079], 'mediator': [791], 'An': [799], '(6Wang': [811, 1658], 'Y.': [812, 940, 1047, 1265, 1291, 1306, 1340, 1380, 1551, 1583, 1607, 1622, 1659, 1722, 1820, 1891, 2144, 2169, 2688, 2702, 2784, 3306], 'Su': [813, 1660], 'B.': [814, 1404, 1661], 'Sah': [815, 1662], 'V.P.': [816, 1663], 'Brown': [817, 1042, 1546, 1664, 2683, 3301], 'J.H.': [818, 1043, 1547, 1665, 2625, 2684, 3302], 'Han': [819, 1666], 'Chien': [821, 1105, 1258, 1301, 1576, 1617, 1668, 1715, 1786, 1824, 1884, 2137, 2706, 2777], 'K.R.': [822, 1106, 1302, 1618, 1669, 1787, 1825, 2707, 3217], 'Biol.': [824, 912, 1671, 1789, 1829, 2711, 3050], 'Chem.': [825, 913, 1672, 1790, 1830, 2712], '273:': [827, 1674, 1792], '5423-5426Abstract': [828, 1675], '(296)': [836, 1683], '7Choukroun': [839], 'G.': [840, 863], 'Hajjar': [841, 864], 'Kyriakis': [843], 'J.M.': [844], 'Bonventre': [845], 'J.V.': [846], 'Rosenzweig': [847, 877], 'Force': [849, 879], 'Clin.': [852, 882, 2641], 'Invest.': [853, 883, 2642], '102:': [855], '1311-1320Crossref': [856], '(179)': [859], '8Choukroun': [862], 'Fry': [866], 'S.': [867, 872, 910, 1271, 1394, 1589, 1728, 1776, 1818, 1897, 2150, 2186, 2700, 2790, 2856, 2862, 2898, 2904], 'del': [868], 'Monte': [869], 'F.': [870], 'Haq': [871], 'Guerrero': [873], 'J.L.': [874], 'Picard': [875], 'M.': [876, 908, 1251, 1284, 1295, 1348, 1569, 1600, 1611, 1708, 1877, 2130, 2633, 2770, 2860, 2902], '1999;': [884, 1831, 2643, 2713], '104:': [885, 2644], '391-398Crossref': [886], '(153)': [889], 'Scholar)': [891, 952, 1083, 1280, 1317, 1906, 2159, 2376, 3078], 'well': [893, 2427], 'cardiomyocyte': [895, 1455, 3543], 'apoptosis': [896, 1456, 2533, 3544, 3612, 3886], '(9Aoki': [897], 'H.': [898, 1098, 1108, 1255, 1402, 1573, 1712, 1881, 2134, 2774], 'Kang': [899], 'P.M.': [900], 'Hampe': [901], 'Yoshimura': [903], 'K.': [904, 1259, 1286, 1577, 1602, 1716, 1885, 2138, 2778, 2932], 'Noma': [905], 'Matsuzaki': [907], 'Izumo': [909], '2002;': [914, 1050, 1076, 1554, 2447, 2691, 2865, 2907, 2939, 3309], '277:': [915], '10244-10250Abstract': [916], '(294)': [924], 'Recently,': [927], 'Molkentin': [928, 941, 1210, 1381], 'co-workers': [930], '(10Liang': [931, 1371], 'Q.': [932, 1372], 'Bueno': [933, 1373], 'O.F.': [934, 1188, 1374], 'Wilkins': [935, 1375], 'B.J.': [936, 1376], 'Kuan': [937, 1377], 'C.-Y.': [938, 1378], 'Xia': [939, 1379], 'J.D.': [942, 1211, 1289, 1382, 1605], 'EMBO': [943, 1212, 1383, 1407], '2003;': [945, 1385], '22:': [946, 1386], '5079-5089Crossref': [947, 1387], '(150)': [950, 1390], 'also': [953, 3389, 3493], 'anti-hypertrophic': [956], 'function': [964, 983, 4208], 'approaches.': [965], 'Thus,': [966], 'considerable': [967], 'evidence': [968, 1495], 'implicates': [969], 'pathogenesis,': [974], 'on': [981, 1146, 1954, 2012, 2211, 2301, 2507, 3554], 'morphology': [985, 3439], 'not': [987, 1449, 3473, 3608], 'fully': [989], 'vivo,': [992], 'different': [1000], 'during': [1005], 'remains': [1008], 'We': [1010], 'previously': [1012, 1537, 1869, 2121, 2361, 2400, 2761, 2849, 3146, 3213], 'linked': [1013], 'aspect': [1019], 'remodeling,': [1023], 'stress-induced': [1024], 'down-regulation': [1025], '(Cx43)': [1033], '(11Petrich': [1034, 1538, 2675, 3293], 'B.G.': [1035, 1539, 2676, 3294], 'Gong': [1036, 1540, 2677, 3295], 'X.': [1037, 1041, 1541, 1545, 2678, 2682, 3296, 3300], 'Lerner': [1038, 1252, 1542, 1570, 1709, 1878, 2131, 2679, 2771, 3149, 3297], 'D.L.': [1039, 1543, 2680, 3150, 3298], 'Wang': [1040, 1046, 1264, 1305, 1544, 1550, 1582, 1621, 1721, 1890, 2143, 2681, 2687, 2783, 3299, 3305], 'Saffitz': [1044, 1256, 1548, 1574, 1713, 1882, 2135, 2685, 2775, 3155, 3303], 'J.E.': [1045, 1549, 2403, 2686, 3156, 3304], '91:': [1051, 1077, 1555, 2692, 3310], '640-647Crossref': [1052, 1556, 2693, 3311], '(126)': [1055, 1559, 2696, 3314], 'Loss': [1058], 'common': [1064], 'feature': [1065], 'failing': [1068], '(12Barker': [1070], 'Gourdie': [1072, 2443], 'R.G.': [1073, 2444], '556-558Crossref': [1078], '(13)': [1081], 'importantly': [1090], 'arrythmogenesis': [1092], '(13Gutstein': [1093], 'D.E.': [1094], 'Morley': [1095], 'G.E.': [1096], 'Tamaddon': [1097], 'Vaidya': [1099], 'D.': [1100, 1247, 1253, 1565, 1571, 1704, 1710, 1873, 1879, 2126, 2132, 2766, 2772, 3035], 'Schneider': [1101], 'M.D.': [1102], 'Chen': [1103, 1296, 1612, 1826, 2708], 'Stuhlmann': [1107], 'Fishman': [1109], 'G.I.': [1110], '2001;': [1113, 1273, 1591, 1730, 1899, 2152, 2792, 3051, 3073, 3161], '88:': [1114], '333-339Crossref': [1115], '(587)': [1118], 'report,': [1123], 'examined': [1125, 3790, 4154], 'specificity': [1127, 3392], 'JNK-induced': [1129, 1141], 'Cx43': [1134, 1144, 2390, 2423, 2485], 'functional': [1138, 1432], 'propagation': [1149], 'heart.': [1153], 'Efforts': [1154], 'establish': [1156], 'pathway': [1165], 'were': [1168, 1692, 1740, 1749, 1860, 1908, 1936, 1952, 2010, 2024, 2077, 2098, 2236, 2244, 2255, 2271, 2280, 2287, 2299, 2502, 2515, 2558, 2589, 2611, 2658, 2728, 2745, 2749, 2821, 2871, 2913, 3088, 3106, 3142, 3233, 3522, 3789, 3939], 'complicated': [1169], 'difficulty': [1171], 'generating': [1173], 'stable': [1174], 'lines': [1176], 'due': [1177], 'severe': [1179], 'phenotypes': [1181], 'premature': [1185], 'death': [1186], '(14Bueno': [1187], 'De': [1189], 'Windt': [1190], 'L.J.': [1191], 'Tymitz': [1192], 'K.M.': [1193], 'Witt': [1194], 'S.A.': [1195], 'Kimball': [1196], 'T.R.': [1197], 'Klevitsky': [1198], 'Hewett': [1200], 'T.E.': [1201, 3037], 'Jones': [1202], 'S.P.': [1203], 'Lefer': [1204], 'D.J.': [1205], 'Peng': [1206], 'C.-F.': [1207], 'Kitsis': [1208], 'R.N.': [1209], '19:': [1215], '6341-6350Crossref': [1216], '(640)': [1219], 'avoid': [1223], 'obstacles,': [1225], 'employed': [1227], 'strategy,': [1232], 'which': [1233], 'had': [1235, 3321, 3460], 'successfully': [1237], 'study': [1239], 'p38': [1240, 3385, 3404], '(15Liao': [1244, 1701, 1870, 2123, 2763], 'P.': [1245, 1350, 1563, 1702, 1871, 2124, 2627, 2764, 3040, 3044], 'Georgakopoulos': [1246, 1564, 1703, 1872, 2125, 2765], 'Kovacs': [1248, 1566, 1705, 1874, 2127, 2628, 2767], 'Zheng': [1250, 1568, 1707, 1876, 2129, 2769], 'Pu': [1254, 1572, 1711, 1880, 2133, 2773], 'Xiao': [1260, 1578, 1717, 1886, 2139, 2779], 'R.-P.': [1261, 1579, 1718, 1887, 2140, 2780], 'Kass': [1262, 1580, 1719, 1888, 2141, 2781], 'D.A.': [1263, 1581, 1720, 1889, 2142, 2782], 'Proc.': [1266, 1584, 1723, 1892, 2145, 2181, 2785], 'Natl.': [1267, 1585, 1724, 1893, 2146, 2182, 2786], 'Acad.': [1268, 1586, 1725, 1894, 2147, 2183, 2787], 'Sci.': [1269, 1587, 1726, 1895, 2148, 2184, 2788], 'U.': [1270, 1588, 1727, 1896, 2149, 2185, 2789], '98:': [1274, 1592, 1731, 1900, 2153, 2793], '12283-12288Crossref': [1275, 1593, 1732, 1901, 2154, 2794], '(289)': [1278, 1596, 1735, 1904, 2157, 2797], 'Ras': [1282], '(16Zheng': [1283], 'Dilly': [1285, 1601], 'Santos': [1287, 1603], 'Cruz': [1288, 1604, 2041], 'Gu': [1290, 1606, 1819, 2701], 'Ursitti': [1292, 1608], 'J.A.': [1293, 1609], 'Li': [1294, 1610], 'Ross': [1298, 1614, 1783, 1821, 2703], 'Jr.,': [1299, 1615, 1784, 1822, 2704], 'Lederer': [1303, 1619], 'J.W.': [1304, 1620], 'Am.': [1307, 1623, 2412, 3045], 'Physiol.': [1309, 1625, 2414], '2004;': [1310, 1626], '286:': [1311, 1627], 'H424-H433Crossref': [1312, 1628], '(72)': [1315, 1631], 'target': [1319, 2232], 'constutively': [1324], 'active': [1325], 'MKK7': [1326, 1331, 2039], 'mutant,': [1327], 'can': [1332], 'activate': [1333], 'all': [1334], 'three': [1335, 2331, 2334, 3839, 3842, 3933, 3936], 'known': [1336], 'isoforms': [1338, 1368], '(17Fleming': [1339], 'Armstrong': [1341], 'C.G.': [1342], 'Morrice': [1343], 'N.': [1344, 2930], 'Paterson': [1345], 'Goedert': [1347], 'Cohen': [1349], '352:': [1354], '145-154Crossref': [1355], '(169)': [1358], 'Scholar),': [1360, 1737, 3027, 3058], 'JNK1': [1362, 2072], 'JNK2': [1364], 'expressed': [1367, 2881, 3234], '18Gupta': [1393], 'Barrett': [1395], 'Whitmarsh': [1397], 'Cavanagh': [1399], 'Sluss': [1401], 'Derijard': [1403], 'Davis': [1405], '15:': [1410], '2760-2770Crossref': [1411], '(1177)': [1414], 'unique': [1418], 'animal': [1419], 'model': [1420, 3274], 'allowed': [1421], 'us': [1422], 'perform': [1424], 'comprehensive': [1426], 'at': [1428, 2005, 2019, 2222, 2739], 'morphological,': [1429], 'molecular,': [1430], 'levels.': [1433], 'Contrary': [1434], 'previous': [1436], 'reports': [1437], 'cultured': [1439], 'myocytes,': [1441], 'our': [1442, 3616, 4227], 'sufficient': [1450, 3609], 'induce': [1452, 3611], 'vivo.': [1458, 3614], 'Instead,': [1459], 'leads': [1463, 3628], '(ECM)': [1471], 'wall': [1482, 3583, 3983, 4008, 4082, 4095], 'compliance': [1483], 'decrease': [1487, 4235, 4244], 'epicardial': [1489], 'velocity.': [1491, 4042], 'suggests': [1496], 'vital': [1503], 'mediating': [1506], 'Generation': [1516], 'Transgenic': [1518, 1686, 4206], 'Animals—The': [1519], 'cloning': [1520], 'α-myosin': [1523], 'heavy': [1524, 3534], 'chain-flox-MKK7D': [1525], 'construct': [1526], 'Cre-mediated': [1529, 3337], 'removal': [1530], 'GFP': [1532, 2037, 3323], '(gene-switch)': [1533], 'described': [1536, 1700, 1868, 2122, 2360, 2401, 2438, 2518, 2623, 2762, 2850, 2884, 2960, 3081, 3145, 3212, 3292], '15Liao': [1562], '16Zheng': [1599], 'Briefly,': [1634, 2196], 'cDNA': [1636], 'fragment': [1637], 'encoding': [1638], 'human': [1639], 'D': [1644], '(MKK7D)': [1645, 1852, 3320, 3502], '(Ser271': [1646], 'Thr275': [1648], 'Asp)': [1650], 'mutant': [1651], 'inserted': [1653, 2755], 'into': [1654, 2756, 2918], 'pflox': [1656], 'vector': [1657], 'harboring': [1688], 'floxed-MKK7D': [1690, 1747, 1806, 1855, 2655, 2668], 'transgene': [1691], 'identified': [1693, 1861], 'Southern': [1695], 'blots': [1696], 'PCR': [1698, 1863], 'colonies': [1739], 'Blackswiss': [1744], 'background.': [1745], 'mice': [1748, 1753, 1810, 1856, 1859, 1939, 2657, 2669, 3411, 3459, 3867, 4170], 'then': [1750], 'bred': [1751], 'possessing': [1754], 'coding': [1757, 2228], 'Cre': [1759], 'recombinase': [1760], 'under': [1761], 'regulation': [1763], 'chain-2v': [1768], 'promoter': [1769], '(MLC-2v/Cre)': [1770], '(19Chen': [1771], 'Kubalak': [1773], 'S.W.': [1774], 'Minamisawa': [1775], 'Price': [1777, 2441], 'R.L.': [1778, 2442], 'Becker': [1779], 'K.D.': [1780, 2928], 'Hickey': [1781], '1252-1256Abstract': [1793], '(149)': [1801], 'GFP-expressing': [1805], 'Cre-expressing': [1808], 'MLC-2v/Cre': [1809, 1858], 'no': [1812, 2671], 'detectable': [1813, 2672, 3588], 'abnormal': [1814], 'phenotype': [1816], '(20Minamisawa': [1817], '274:': [1832, 2714], '10066-10070Abstract': [1833, 2715], '(36)': [1841, 2723], '2B.': [1844], 'Petrich,': [1845], 'unpublished': [1846], 'results.': [1847], 'double': [1849], 'offspring': [1851, 3319], 'tail': [1865], 'DNA': [1866, 3338], 'analyzed': [1909, 2347, 2378, 2872, 2915, 3940], 'between': [1910], '6': [1911, 2740, 3791], '8': [1913], 'age/sex-matched': [1918], 'littermates': [1919], 'genotypes': [1921], 'floxed-MKK7D,': [1923], 'MLC-2v/Cre,': [1924], 'wild': [1926, 2732], 'type': [1927, 2733], 'controls.': [1929, 2556], 'Protein': [1930, 2022], 'RNA': [1932, 2096, 2115, 2201, 2954, 3087, 3852], 'Dot-blot': [1933], 'Analysis—Whole': [1934], 'excised': [1937], 'snap': [1941], 'frozen': [1942, 2011, 2434], 'liquid': [1944], 'nitrogen.': [1945], 'obtain': [1947], 'extracts,': [1949], 'left': [1950, 2356, 2758, 2808, 2957, 3451, 3558, 3680, 3759, 3855, 3894, 3998, 4023, 4051, 4089, 4102, 4116, 4164, 4180], 'ventricles': [1951, 2809, 2958, 3332, 3856], 'pulverized': [1953], 'dry': [1955, 2014], 'ice': [1956], 'homogenized': [1958], 'cell': [1960], 'lysis': [1961], 'buffer': [1962], 'containing': [1963, 2564], '20': [1964, 3130], 'mm': [1965, 1970, 1973, 1979, 1983, 1986, 1989], 'Tris': [1966], '(pH': [1967], '7.4),': [1968], '150': [1969], 'EDTA,': [1971], '1': [1972, 1982, 1985, 1988], 'EGTA,': [1974], '1%': [1975], 'Triton': [1976], 'X-100,': [1977], '2.5': [1978], 'sodium': [1980], 'pyrophosphate,': [1981], 'β-glycerophosphate,': [1984], 'Na3VO4,': [1987], 'phenylmethylsulfonyl': [1990], 'fluoride,': [1991], 'protease': [1994], 'inhibitor': [1995], 'mixture': [1996], '(Roche': [1997], 'Applied': [1998], 'Science).': [1999], 'After': [2000], '10-min': [2001], 'microcentrifugation': [2002], '(10,000': [2003], 'rpm)': [2004], '4': [2006], '°C,': [2007], 'supernatants': [2009], 'ice/ethanol': [2015], 'bath': [2016], 'stored': [2018], '-80': [2020], '°C.': [2021], 'samples': [2023, 2097, 2806], 'subjected': [2025], 'SDS-PAGE,': [2027], 'transferred': [2028], 'nitrocellulose': [2030], 'membranes,': [2031], 'blotted': [2033, 2210], 'antibodies': [2035, 2061, 2461, 2494, 3383], 'against': [2036, 2251, 2468, 3384], '(Clontech),': [2038], '(Santa': [2040], 'Biotechnology,': [2042], 'Inc.,': [2043, 2497], 'Santa': [2044], 'Cruz,': [2045], 'CA),': [2046], 'p38,': [2047], 'phospho-p38,': [2048], 'phospho-ERK,': [2050], 'phospho-JNK': [2053, 2060, 3362], '(Cell': [2054], 'Signaling,': [2055], 'Inc.).': [2056], 'p46': [2065, 3349], 'p54': [2067, 3353], 'composed': [2069], 'primarily': [2070], 'JNK2,': [2074], 'respectively.': [2075], 'detected': [2078, 2458], 'Pico': [2081], 'West': [2082], 'System': [2083, 2969], '(Pierce),': [2084], 'exposed': [2085], 'x-ray': [2087], 'film,': [2088], 'quantified': [2090, 2237, 2981], 'Scion': [2092], 'NIH': [2093], 'Image': [2094, 3877, 3956, 4192], 'software.': [2095], 'prepared': [2099], 'same': [2102, 2268], 'tissues': [2104], 'TRIZOL': [2106], 'reagent': [2107, 2825], '(Invitrogen)': [2108], 'according': [2109], "manufacturer's": [2112, 2540], 'recommended': [2113, 2890], 'protocol.': [2114, 2541], 'dot-blot': [2116, 3848], 'performed': [2119, 2358, 2394, 2432, 2526, 2612, 2837, 2963, 3107, 3143, 3553], 'set': [2162], 'oligonucleotide': [2164, 2221], 'probes': [2165], "(21D'Angelo": [2166], 'D.D.': [2167], 'Sakata': [2168], 'Lorenz': [2170], 'J.N.': [2171], 'Boivin': [2172], 'G.P.': [2173], 'Walsh': [2174], 'R.A.': [2175], 'Liggett': [2176], 'S.B.': [2177], 'Dorn': [2178], 'II,': [2179, 4223], 'G.W.': [2180], '1997;': [2188], '94:': [2189], '8121-8126Crossref': [2190], '(537)': [2193], '2': [2197, 2843], 'μg': [2198, 2951], 'total': [2200, 2953, 3365, 3380, 3851], 'isolated': [2202, 2955], 'cellulose': [2212], 'membrane': [2213], '(Schleicher': [2214], '&': [2215], 'Schüll)': [2216], 'hybridized': [2218], '32P-labeled': [2220], 'various': [2223], 'lengths': [2224], 'complement': [2226], 'sequence': [2229], 'mRNAs.': [2233], 'Hybridization': [2234], 'signals': [2235], 'PhosphorImager': [2240], '(Amersham': [2241], 'Biosciences)': [2242], 'presented': [2245, 2600], 'relative': [2247], 'pixel': [2248], 'value': [2249, 3252], 'normalized': [2250, 3477, 3868], 'GAPDH.': [2252], 'Histological': [2253], 'Analysis—Hearts': [2254], 'perfusion': [2256], 'fixed': [2257], '4%': [2259], 'paraformaldehyde/phosphate-buffered': [2260], 'saline': [2261], 'followed': [2262, 2488, 3117], 'overnight': [2264], 'incubation': [2265], 'fixative.': [2269], 'Hearts': [2270], 'dehydrated': [2272], 'embedded': [2274, 2397], 'paraffin,': [2276], '6-μm-thick': [2278], 'sections': [2279, 2286, 2354, 2398, 2436, 3555, 3806, 3917, 4166, 4182], 'cut.': [2281], 'Deparaffinized': [2282], 'rehydrated': [2284], 'stained': [2288, 3807, 4183], 'Alexa-568-conjugated': [2290, 2492], 'wheat': [2291, 3811], 'germ': [2292, 3812], 'agglutinin': [2293, 3813], 'outline': [2295], 'myocyte': [2296, 3817], 'membranes': [2297], 'viewed': [2300, 2573], 'Zeiss': [2303, 2384, 2509, 2576], 'IM-35': [2304, 2577], 'fluorescence': [2305, 2578, 4157], 'microscope': [2306], 'equipped': [2307], 'Spot': [2310, 2593], 'CCD': [2311, 2594], 'camera': [2312, 2342, 2595], '(Diagnostic': [2313, 2596], 'Instruments).': [2314, 2597], 'Myocyte': [2315], 'area': [2316, 3485], 'calculated': [2318, 3943], '15': [2320], 'myocytes/field': [2321], 'five': [2323, 2731], 'random': [2324, 2584, 3832, 3926], 'fields': [2325, 2585, 3833, 3927], 'view': [2327, 3835, 3929], 'each': [2329, 2587, 3837, 3931], 'control': [2335, 2819, 2888, 3652, 3787, 3804, 3843, 3863, 3937, 3968, 4172], 'software': [2338, 2924], 'supplied': [2339, 2971], 'manufacturer.': [2343], 'Collagen': [2344], 'content': [2345], 'picrosirius': [2349, 4160], 'red': [2350, 4161], 'staining': [2351, 3551, 3905, 4162], 'deparaffinized': [2353], 'ventricle': [2357, 2759, 3582, 3805, 3895, 3999, 4024, 4090, 4103, 4165, 4181], '(22Dolber': [2362], 'P.C.': [2363], 'Spach': [2364], 'M.S.': [2365], 'Histochem.': [2367], 'Cytochem.': [2368], '1993;': [2369], '41:': [2370], '465-469Crossref': [2371], '(143)': [2374], 'confocal': [2380, 2386, 2511, 4156, 4176], 'microscopy': [2381, 4158], '410': [2385, 2510], 'microscope.': [2387, 2512], 'Immunohistochemistry—Immunostaining': [2388], 'cadherins': [2392], 'paraffin': [2396], '(23Saffitz': [2402], 'Green': [2404, 2995], 'K.G.': [2405], 'Kraft': [2406], 'W.J.': [2407], 'Schechtman': [2408], 'K.B.': [2409], 'Yamada': [2410, 3151], 'K.A.': [2411, 3152], '278:': [2416], 'H1662-H1670PubMed': [2417], 'Double': [2420, 3317], 'labeling': [2421, 2524], 'ZO-1,': [2425], 'fibronectin': [2429, 2463], 'immunostaining,': [2430], '(24Barker': [2439], '90:': [2448], '317-324Crossref': [2449], '(164)': [2452], 'Immunoreactive': [2455], 'signal': [2456], 'polyclonal': [2460], '(Sigma),': [2464], 'pan': [2465], 'cadherin,': [2466], 'made': [2467], 'COOH-terminal': [2470], 'amino': [2471], 'acids': [2472], 'chicken': [2474], 'N-cadherin': [2475], '(Sigma)': [2476, 2549], 'ZO-1': [2478], '(Zymed': [2479], 'Laboratories': [2480], 'Inc.)': [2481], 'monoclonal': [2484], 'antibody': [2486], '(Chemicon)': [2487], 'Alexa-488': [2490], 'secondary': [2493], '(Molecular': [2495], 'Probes,': [2496], 'Eugene,': [2498], 'OR).': [2499], 'All': [2500, 3104], 'images': [2501, 2581, 3800], 'captured': [2503, 2590], 'identical': [2505], 'settings': [2506], 'TUNEL': [2513, 2523, 3550, 3897, 3913], 'Assay—Hearts': [2514], 'processed': [2516], 'above': [2519, 2961], 'histologic': [2521], 'analysis.': [2522], 'ApopTag': [2529], 'fluorescein': [2530], 'situ': [2532], 'detection': [2534], 'kit': [2535, 2832], '(Intergen)': [2536], 'following': [2538, 3110], 'Sections': [2542, 2557], 'incubated': [2543], '10': [2545, 2551, 3115], 'units/ml': [2546], 'deoxyribonuclease': [2547], 'I': [2548], 'min': [2552, 3116], 'served': [2553, 3918], 'positive': [2555, 3921], 'counterstained': [2559], 'antifade': [2561], 'mounting': [2562], 'medium': [2563], '0.5': [2565], 'μg/ml': [2566], 'propidium': [2567, 3903], 'iodide': [2568, 3904], 'coverslipped.': [2570], 'Staining': [2571], 'microscope,': [2579], 'six': [2583, 3831, 3925], 'sample': [2588], 'Results': [2598], 'TUNEL-positive': [2602, 3947], 'cells/total': [2603, 3948], 'nuclei.': [2604], 'Echocardiography': [2605], 'Hemodynamic': [2607, 2726], 'Measurement—Noninvasive': [2608], 'transthoracic': [2609], 'echocardiograms': [2610], '6-week-old': [2614], 'conscious': [2615], '(Sequoia,': [2617], 'Acuson,': [2618], 'Mountain': [2619], 'View,': [2620], 'CA)': [2621], '(25Rogers': [2624], 'Tamirisa': [2626], 'Weinheimer': [2630], 'Courtois': [2632], 'Blumer': [2634], 'K.J.': [2635], 'Kelly': [2636], 'D.P.': [2637], 'Muslin': [2638], '567-576Crossref': [2645], '(171)': [2648], 'Wild': [2651], 'type,': [2652], 'MLC2v/Cre,': [2653], 'grouped': [2659, 2917], 'together': [2660], 'controls': [2662, 2734, 3376, 3497, 3573], 'echocardiography,': [2664], 'since': [2665], 'MLC/2v/Cre': [2666], 'abnormalities': [2674], '20Minamisawa': [2699], 'measurements': [2727], 'obtained': [2729, 3829], 'two': [2736], 'age.': [2743], 'Animals': [2744], 'anesthetized,': [2746], 'hemodynamics': [2748], 'measured': [2750, 3172, 3192], 'pressures-volumes': [2753], 'catheter': [2754], 'Microarray': [2800], 'Real': [2802], 'Time': [2803], 'RT-PCR': [2804, 2985], 'Analysis—RNA': [2805], 'age-': [2814], 'sex-matched': [2816], 'nontransgenic': [2817], 'littermate': [2818], 'extracted': [2822, 3853], 'Trizol': [2824], 'purified': [2827], 'Rneasy': [2830], 'Mini': [2831], '(Qiagen).': [2833], 'Transcriptional': [2834], 'profiling': [2835], 'murine': [2839], 'genome': [2840], 'U74A': [2841], 'version': [2842], 'GeneChip': [2844], 'arrays': [2845], '(Affymetrix)': [2846], 'exactly': [2847], '(26Thimmulappa': [2851, 2893], 'R.K.': [2852, 2894], 'Mai': [2853, 2895], 'K.H.': [2854, 2896], 'Srisuma': [2855, 2897], 'Kensler': [2857, 2899], 'T.W.': [2858, 2900], 'Yamamoto': [2859, 2901], 'Biswal': [2861, 2903], 'Cancer': [2863, 2905], '62:': [2866, 2908], '5196-5203PubMed': [2867, 2909], 'Data': [2870, 2874, 2912], 'Mining': [2875], 'Tool': [2876], '3.0': [2877], '(Affymetrix),': [2878], 'differentially': [2880], 'transcripts': [2882], '-fold': [2886], 'change': [2887], 'Affymetrix': [2892], 'further': [2914], 'functionally': [2919], 'related': [2920], 'groups': [2921], 'GenMAPP': [2923], '(Gladstone': [2925], 'Institutes)': [2926], '(27Dahlquist': [2927], 'Salomonis': [2929], 'Vranizan': [2931], 'Lawlor': [2933], 'S.C.': [2934], 'Conklin': [2935], 'B.R.': [2936], 'Nat.': [2937], 'Genet.': [2938], '31:': [2940], '19-20Crossref': [2941], '(804)': [2944], 'Reverse': [2947], 'transcription': [2948], '5': [2950], 'Superscript': [2966], 'First-Strand': [2967], 'Synthesis': [2968], 'oligo(dT)': [2972], 'primers': [2973, 3096], '(Invitrogen).': [2974], 'Relative': [2975], 'abundance': [2976], 'real': [2983, 2988, 3001], 'time': [2984, 2989, 3002, 3195, 3205, 4048, 4113], '(iCycler': [2986], 'iQ': [2987], 'PCR;': [2990], 'Bio-Rad)': [2991], 'IQ': [2993], 'SYBR': [2994], 'Supermix': [2996], '(Bio-Rad).': [2997], 'Primers': [2998], 'RT-PCRs': [3003], 'β1': [3009], '(TGF-β1)': [3010], '(28Shaddy': [3011], 'R.E.': [3012], 'Zhang': [3013], 'Y.L.': [3014], 'White': [3015], 'W.L.': [3016], 'Mol.': [3018, 3049, 3070], 'Med.': [3019], '57:': [3021], '10-13Crossref': [3022], '(8)': [3025], 'TGF-β2,': [3028], 'TGF-β3,': [3029], 'TGF-β': [3030, 3060], 'RII': [3031], '(29Rosendahl': [3032], 'Checchin': [3034], 'Fehniger': [3036], 'ten': [3038], 'Dijke': [3039], 'Heldin': [3041], 'C.-H.': [3042], 'Sideras': [3043], 'Respir.': [3047], 'Cell': [3048], '25:': [3052], '60-68Crossref': [3053], '(118)': [3056], 'RI': [3061], '(30Chow': [3062], 'J.F.C.': [3063], 'Lee': [3064], 'K.-F.': [3065], 'Chan': [3066], 'S.T.H.': [3067], 'Yeung': [3068], 'W.S.B.': [3069], 'Hum.': [3071], 'Reprod.': [3072], '7:': [3074, 3224], '1047-1056Crossref': [3075], 'previously.': [3082], 'Equal': [3083], 'starting': [3084], 'amounts': [3085], 'insured': [3089], 'normalizing': [3091], 'GAPDH': [3093, 3097, 3101, 3870], 'forward': [3098], '(5′-TCCTGCACCACCAACTGCTTAG-3′': [3099], '5′-GATGACCTTGCCCACAGCCTTG-3′.': [3103], 'reactions': [3105], 'parameters:': [3111], '94': [3112, 3122], '°C': [3113, 3123, 3128, 3134], '40': [3119], 'cycles': [3120], '25': [3125, 4189], 's,': [3126, 3131], '55': [3127], '72': [3133], '45': [3136], 's.': [3137], 'Optical': [3138], 'Mapping—Optical': [3139], 'mapping': [3140], 'experiments': [3141], '(31Eloff': [3147], 'B.C.': [3148], 'Schuessler': [3153], 'R.B.': [3154], 'Rosenbaum': [3157, 3218], 'D.S.': [3158, 3219], 'Cardiovasc.': [3159, 3221], '51:': [3162], '681-690Crossref': [3163], '(134)': [3166], 'Conduction': [3169], 'velocity': [3170, 3176], 'averaging': [3174], 'local': [3175], 'vectors': [3177], 'contiguous': [3179], 'sites': [3180], 'transverse': [3181], 'longitudinal': [3183], 'fibers.': [3186], 'Action': [3187], 'duration': [3189], '(APD)': [3190], '70%': [3199], 'repolarization,': [3200], 'rise': [3204], 'corrected': [3207], 'optical': [3209], 'blurring': [3210], '(32Girouard': [3214], 'S.D.': [3215, 3238, 3951], 'Laurita': [3216], 'Electrophysiol.': [3222], '1024-1038Crossref': [3225], '(186)': [3228], 'Statistical': [3231, 3239], 'Analysis—Results': [3232], 'mean': [3236], '±': [3237, 3499, 3505, 3657, 3662, 3670, 3675, 3683, 3688, 3699, 3704, 3710, 3715, 3722, 3727, 3742, 3950, 3978, 3980, 3986, 3988, 3994, 3996, 4003, 4005, 4011, 4013, 4019, 4021, 4028, 4030, 4035, 4037, 4044, 4046, 4055, 4057, 4069, 4071], 'significance': [3240], 'assessed': [3242, 3892], "Student's": [3244], 'paired': [3245], 'two-tailed': [3246], 't': [3247], 'test': [3248], 'p': [3251, 3509, 3761, 3767, 3873, 4119, 4130], '<0.05': [3254], 'considered': [3255], 'be': [3257], 'statistically': [3258, 3474], 'significant.': [3259], 'Cardiac': [3260, 3438], 'Pathology': [3261], 'Induced': [3262], 'Targeted': [3264], 'Activation': [3265], 'Ventricular': [3269], 'Myocytes': [3270], 'Vivo—A': [3272], 'myocytes': [3282, 3488, 3625], 'diminished': [3322], 'result': [3335], 'recombination': [3339], '(Fig.': [3340, 3377, 3408, 3455, 3538, 3574], '1A).': [3341], 'both': [3348, 3450], '(primarily': [3350, 3354], 'JNK1)': [3351], 'JNK2)': [3355], 'determined': [3357], 'immunoblotting': [3359], 'antibody,': [3363], 'whereas': [3364], 'levels': [3368], 'remained': [3369], 'unchanged': [3370, 3494], 'compared': [3374, 3467, 3495], '1B).': [3378, 3409], 'Using': [3379], 'phosphospecific': [3382], 'activating': [3396], 'ERK': [3406], 'activities': [3407], 'failure,': [3422], 'including': [3423, 3524], 'increased': [3424], 'lung': [3425, 3647], 'weight/body': [3426], 'weight': [3427, 3480], 'ratio': [3428], '(Table': [3429, 3481, 3596], 'I),': [3430], 'ascites,': [3431], 'dyspnea,': [3432], 'lethargy': [3434], '(Supplemental': [3435], 'Fig.': [3436, 3512, 3599, 3779, 4142], '1).': [3437], 'characterized': [3445], 'enlargement': [3448], 'right': [3453, 3667, 3756], 'atria': [3454], '2A).': [3456], 'Although': [3457], 'modest': [3462, 3579, 4243], 'reduction': [3463], 'mass': [3466], 'controls,': [3469], 'difference': [3471], 'when': [3476], 'body': [3479, 3654, 3753], 'I).': [3482], 'cross-sectional': [3484, 3818], '(210': [3498], '70': [3500], 'μm2': [3501], 'versus': [3503, 3651, 3696, 3735, 3750, 3765, 3771, 3967, 4062, 4076, 4123, 4134], '206': [3504], '71': [3506], '(control)': [3507], 'μm2,': [3508], '>': [3510], '0.5,': [3511], '2B).': [3513], 'Marker': [3514], 'induced,': [3523], 'atrial': [3525], 'natriuretic': [3526], 'factor,': [3527], 'characteristic': [3530, 3632], 'α-': [3531], 'β-myosin': [3533], 'chain': [3535], 'isoform': [3536], '2C).': [3539], 'assess': [3541], 'possible': [3542], 'ventricle.': [3559, 3668, 3681], 'number': [3561], 'apoptotic': [3563], 'nuclei': [3564], 'similar': [3569], '3),': [3575], 'consistent': [3576], 'decreases': [3580], 'thickness': [3584], 'lack': [3586], 'replacement': [3589], 'fibrosis': [3590], '(see': [3594], 'below)': [3595], 'II': [3597], '4).': [3600], 'suggest': [3603], 'Together,': [3615], 'findings': [3617], 'indicate': [3618], 'phenotypic': [3630], 'absence': [3639], 'apoptosis.Table': [3644], 'IHeart': [3645], 'weights': [3648], 'miceControlMKK7DBWaBW,': [3653], 'weight.': [3655], '(g)22.5': [3656], '4.1': [3658], '(n': [3659, 3664, 3672, 3677, 3685, 3690, 3701, 3706, 3712, 3717, 3724, 3729, 3739, 3744, 3859, 3864, 3970, 3973], '=': [3660, 3665, 3673, 3678, 3686, 3691, 3702, 3707, 3713, 3718, 3725, 3730, 3740, 3745, 3860, 3865, 3971, 3974], '13)19.6': [3661], '4.0': [3663, 3676], '13)RVbRV,': [3666], '(mg)23.4': [3669], '4.6': [3671], '13)21.1': [3674], '13)LVcLV,': [3679], '(mg)66.9': [3682], '13.4': [3684], '13)54.8': [3687], '10.4': [3689], '13)dp': [3692], '<': [3693, 3732, 3747, 3762, 3768, 3874, 4059, 4073, 4120, 4131], '0.05,': [3694, 3763, 4060, 4121], 'control.RV/BW': [3697], '(mg/g)1.1': [3698], '0.2': [3700, 3711], '13)1.1': [3703], '0.3': [3705], '13)LV/BW': [3708], '(mg/g)3.0': [3709], '13)2.9': [3714], '0.6': [3716], '13)Lung': [3719], 'weight/BW': [3720], '(mg/g)2.3': [3721], '0.8': [3723], '11)4.7': [3726], '1.8': [3728], '12)ep': [3731], '0.001,': [3733, 3748, 3769], 'control.Average': [3736], 'lifespan': [3737], '(days)>356': [3738], '20)48': [3741], '8.8': [3743], '20)ep': [3746], 'control.a': [3751, 4077], 'BW,': [3752], 'weight.b': [3754], 'RV,': [3755], 'ventricle.c': [3757], 'LV,': [3758], 'ventricle.d': [3760], 'control.e': [3766], 'control.': [3772, 3922, 4135], 'Open': [3773, 4136], 'table': [3774, 4137], 'new': [3777, 4140], 'tab': [3778, 4141], '2Characterization': [3780], 'birth.': [3794], 'A,': [3795, 4151], 'gross': [3796], 'morphology;': [3797], 'B,': [3798, 4174], 'representative': [3799, 4175], 'fluorescently': [3809], 'labeled': [3810], 'quantify': [3816], 'diameter.': [3819, 4001, 4026], 'Bar,': [3820, 3952], '50': [3821, 3953], 'μm.': [3822], 'Shown': [3823], 'below': [3824], 'summary': [3827], 'data': [3828], 'C,': [3845], 'quantitation': [3846], '4)': [3861], '6)': [3866], 'expression.': [3871], '*,': [3872], '0.05.View': [3875], 'Large': [3876, 3955, 4191], 'Figure': [3878, 3957, 4193], 'ViewerDownload': [3879, 3958, 4194], 'Hi-res': [3880, 3959, 4195], 'image': [3881, 3960, 4178, 4196], 'Download': [3882, 3961, 4197], '(PPT)Fig.': [3883], '3Analysis': [3884], 'Apoptosis': [3891], 'staining.': [3898, 3914], 'top': [3900], 'panels': [3901, 3910], 'show': [3902, 3911], 'nuclei,': [3907], 'bottom': [3909], 'DNase-treated': [3915], 'Images': [3923], 'percentage': [3945], 'cells': [3949], 'μm.View': [3954, 4190], '(PPT)Table': [3962], 'IIEchocardiography': [3963], 'measurement': [3964], 'miceControl': [3969], '4)MKK7D': [3972], '7)M-modeechocardiographyHRaHeart': [3975], 'rate.': [3976], '(bpm)622': [3977], '64586': [3979], '72PWdbDiastolic': [3981], 'posterior': [3982, 4007, 4081, 4094], 'thickness.': [3984, 3992, 4009, 4017], '(mm)0.69': [3985], '0.080.66': [3987], '0.06IVSdcDiastolic': [3989], 'intraventricular': [3990, 4000, 4015, 4025, 4085, 4091, 4098, 4104], 'septum': [3991, 4016, 4086, 4099], '(mm)0.74': [3993], '0.090.71': [3995], '0.08LVIDddDiastolic': [3997], '(mm)2.94': [4002], '0.382.85': [4004], '0.29PWseSystolic': [4006], '(mm)1.39': [4010], '0.061.36': [4012], '0.10IVSsfSystolic': [4014], '(mm)1.44': [4018], '0.091.43': [4020], '0.07LVIDsgSystolic': [4022], '(mm)1.23': [4027], '0.231.15': [4029], '0.16FShFractional': [4031], 'shortening': [4032, 4107], '(LVIDd-LVIDs/LVIDd).': [4033], '(%)58.5': [4034], '4.459.6': [4036], '3.2Trans-mitral': [4038], 'echocardiographyEiPeak': [4040], 'ejection': [4041, 4110], '(m/s)0.77': [4043], '0.080.89': [4045], '0.20DTjDeceleration': [4047], 'early': [4050, 4115], 'filling.': [4053], '(ms)21.0': [4054], '0.814.0': [4056], '1.8kp': [4058], 'control.IVRTlLeft': [4063], 'isovolumic': [4065, 4127], 'relaxation': [4066, 4128], 'time.': [4067], '(ms)15.5': [4068], '0.612.4': [4070], '1.9mp': [4072], '0.0001,': [4074, 4132], 'Heart': [4078], 'rate.b': [4079], 'Diastolic': [4080, 4084, 4088], 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