Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2056019080', 'doi': 'https://doi.org/10.2741/1839', 'title': 'VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy', 'display_name': 'VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy', 'publication_year': 2006, 'publication_date': '2006-01-01', 'ids': {'openalex': 'https://openalex.org/W2056019080', 'doi': 'https://doi.org/10.2741/1839', 'mag': '2056019080', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16146773', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1360224'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2741/1839', 'pdf_url': 'https://www.imrpress.com/journal/FBL/11/1/10.2741/1839/pdf', 'source': {'id': 'https://openalex.org/S185455647', 'display_name': 'Frontiers in bioscience', 'issn_l': '1093-4715', 'issn': ['1093-4715', '1093-9946', '1094-3935'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320848', 'host_organization_name': 'Frontiers in Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310320848'], 'host_organization_lineage_names': ['Frontiers in Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.imrpress.com/journal/FBL/11/1/10.2741/1839/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050700218', 'display_name': 'Nader Rahimi', 'orcid': 'https://orcid.org/0000-0002-6745-1725'}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Nader Rahimi', 'raw_affiliation_strings': ['Department of Ophthalmology, School of Medicine, Boston University, Boston, MA 02118, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, School of Medicine, Boston University, Boston, MA 02118, USA.', 'institution_ids': ['https://openalex.org/I111088046']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5050700218'], 'corresponding_institution_ids': ['https://openalex.org/I111088046'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.882, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 200, 'citation_normalized_percentile': {'value': 0.999677, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': '11', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.975, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11469', 'display_name': 'Lymphatic System and Diseases', 'score': 0.9484, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.8552418}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.75934845}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.66655016}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.6323726}, {'id': 'https://openalex.org/C14858245', 'wikidata': 'https://www.wikidata.org/wiki/Q18028241', 'display_name': 'Kinase insert domain receptor', 'level': 5, 'score': 0.6167564}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.579715}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.4934105}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.47132924}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46154195}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43892705}, {'id': 'https://openalex.org/C146285616', 'wikidata': 'https://www.wikidata.org/wiki/Q7916455', 'display_name': 'Vascular endothelial growth factor A', 'level': 4, 'score': 0.37025765}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.34552526}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.17036235}], 'mesh': [{'descriptor_ui': 'D040281', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040281', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040281', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2741/1839', 'pdf_url': 'https://www.imrpress.com/journal/FBL/11/1/10.2741/1839/pdf', 'source': {'id': 'https://openalex.org/S185455647', 'display_name': 'Frontiers in bioscience', 'issn_l': '1093-4715', 'issn': ['1093-4715', '1093-9946', '1094-3935'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320848', 'host_organization_name': 'Frontiers in Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310320848'], 'host_organization_lineage_names': ['Frontiers in Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1360224', 'pdf_url': 'https://europepmc.org/articles/pmc1360224?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360224', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16146773', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2741/1839', 'pdf_url': 'https://www.imrpress.com/journal/FBL/11/1/10.2741/1839/pdf', 'source': {'id': 'https://openalex.org/S185455647', 'display_name': 'Frontiers in bioscience', 'issn_l': '1093-4715', 'issn': ['1093-4715', '1093-9946', '1094-3935'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320848', 'host_organization_name': 'Frontiers in Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310320848'], 'host_organization_lineage_names': ['Frontiers in Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 82, 'referenced_works': ['https://openalex.org/W1014698510', 'https://openalex.org/W1520077451', 'https://openalex.org/W1558361583', 'https://openalex.org/W1565382746', 'https://openalex.org/W1582187753', 'https://openalex.org/W1639582946', 'https://openalex.org/W1783580437', 'https://openalex.org/W1851295704', 'https://openalex.org/W1911505241', 'https://openalex.org/W1964396270', 'https://openalex.org/W1964533512', 'https://openalex.org/W1965380392', 'https://openalex.org/W1965950769', 'https://openalex.org/W1969695473', 'https://openalex.org/W1973555911', 'https://openalex.org/W1974847622', 'https://openalex.org/W1976489564', 'https://openalex.org/W1976999762', 'https://openalex.org/W1977030165', 'https://openalex.org/W1978981273', 'https://openalex.org/W1978997838', 'https://openalex.org/W1980969801', 'https://openalex.org/W1982085952', 'https://openalex.org/W1985712533', 'https://openalex.org/W1986559037', 'https://openalex.org/W1987644022', 'https://openalex.org/W1987821958', 'https://openalex.org/W1988596206', 'https://openalex.org/W1989217499', 'https://openalex.org/W1995456587', 'https://openalex.org/W1995624383', 'https://openalex.org/W1995827857', 'https://openalex.org/W1996537616', 'https://openalex.org/W2001102844', 'https://openalex.org/W2002127663', 'https://openalex.org/W2005018138', 'https://openalex.org/W2005994924', 'https://openalex.org/W2014111401', 'https://openalex.org/W2014148719', 'https://openalex.org/W2015684586', 'https://openalex.org/W2018291504', 'https://openalex.org/W2019529259', 'https://openalex.org/W2019890837', 'https://openalex.org/W2020506302', 'https://openalex.org/W2026351725', 'https://openalex.org/W2028415754', 'https://openalex.org/W2031499319', 'https://openalex.org/W2040283898', 'https://openalex.org/W2041328797', 'https://openalex.org/W2042204791', 'https://openalex.org/W2046525214', 'https://openalex.org/W2047470479', 'https://openalex.org/W2050358495', 'https://openalex.org/W2055519466', 'https://openalex.org/W2063609977', 'https://openalex.org/W2065293283', 'https://openalex.org/W2068688235', 'https://openalex.org/W2069043370', 'https://openalex.org/W2069180517', 'https://openalex.org/W2070732456', 'https://openalex.org/W2074799826', 'https://openalex.org/W2075073662', 'https://openalex.org/W2082313852', 'https://openalex.org/W2084506573', 'https://openalex.org/W2084947524', 'https://openalex.org/W2088796595', 'https://openalex.org/W2090003699', 'https://openalex.org/W2092616666', 'https://openalex.org/W2094173028', 'https://openalex.org/W2098728140', 'https://openalex.org/W2119803906', 'https://openalex.org/W2123060447', 'https://openalex.org/W2135200381', 'https://openalex.org/W2140469576', 'https://openalex.org/W2141046053', 'https://openalex.org/W2144177534', 'https://openalex.org/W2145648498', 'https://openalex.org/W2156496945', 'https://openalex.org/W2161235995', 'https://openalex.org/W2166156136', 'https://openalex.org/W2287632365', 'https://openalex.org/W4211075026'], 'related_works': ['https://openalex.org/W2955618051', 'https://openalex.org/W284991352', 'https://openalex.org/W2360943677', 'https://openalex.org/W2321063763', 'https://openalex.org/W2320148073', 'https://openalex.org/W2160930114', 'https://openalex.org/W2151772280', 'https://openalex.org/W2150814991', 'https://openalex.org/W2029323837', 'https://openalex.org/W2027911638'], 'abstract_inverted_index': {'Angiogenesis': [0], 'involves': [1], 'endothelial': [2], 'cell': [3], 'differentiation,': [4], 'proliferation,': [5], 'migration': [6], 'and': [7, 35, 43, 47, 70, 77, 89, 97, 115, 138, 140, 149], 'cord': [8], 'formation,': [9], 'which': [10], 'lead': [11], 'to': [12, 14, 111, 116], 'tubulogenesis': [13], 'form': [15], 'vessels.': [16], 'One': [17], 'group': [18], 'of': [19, 30, 94, 134, 136], 'growth': [20], 'factor': [21], 'receptors': [22], 'implicated': [23], 'in': [24, 101], 'angiogenesis': [25, 81], 'is': [26, 51, 57], 'the': [27, 132, 143], 'VEGFR': [28], 'family': [29], 'receptor': [31, 40, 87], 'tyrosine': [32, 41], 'kinases.': [33], 'VEGFR-1': [34, 50, 69, 79, 137, 148], 'VEGFR-2': [36, 56, 71, 91, 107, 150], 'are': [37, 72, 119], 'closely': [38], 'related': [39], 'kinases': [42], 'have': [44], 'both': [45, 68], 'common': [46], 'specific': [48], 'ligands.': [49], 'a': [52, 58], 'kinase-impaired': [53], 'RTK': [54], 'whereas': [55], 'highly': [59, 120], 'active': [60], 'kinase.': [61], 'Despite': [62], 'their': [63], 'differential': [64], 'kinase': [65], 'activation': [66, 135], 'potentials,': [67], 'required': [73], 'for': [74], 'normal': [75], 'development': [76], 'angiogenesis.': [78, 153], 'regulates': [80], 'by': [82, 122, 147], 'mechanisms': [83, 104], 'that': [84, 105, 151], 'involve': [85], 'ligand-trapping,': [86], 'homo-': [88], 'heterodimerization.': [90], 'stimulates': [92], 'variety': [93], 'signaling': [95, 113, 144], 'pathways': [96, 145], 'broad': [98], 'biological': [99], 'responses': [100], 'vitro.': [102], 'The': [103], 'govern': [106], 'activation,': [108], 'its': [109, 123], 'ability': [110], 'recruit': [112], 'proteins': [114], 'undergo': [117], 'downregulation': [118], 'regulated': [121], 'carboxyl': [124], 'terminus.': [125], 'This': [126], 'review': [127], 'highlights': [128], 'recent': [129], 'insights': [130], 'into': [131], 'mechanism': [133], 'VEGFR-2,': [139], 'focuses': [141], 'on': [142], 'employed': [146], 'regulate': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056019080', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-30T18:23:46.968672', 'created_date': '2016-06-24'}