Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2055740754', 'doi': 'https://doi.org/10.1371/journal.pone.0076016', 'title': 'SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity', 'display_name': 'SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity', 'publication_year': 2013, 'publication_date': '2013-09-27', 'ids': {'openalex': 'https://openalex.org/W2055740754', 'doi': 'https://doi.org/10.1371/journal.pone.0076016', 'mag': '2055740754', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24086678', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3785417'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0076016', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076016&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076016&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071672445', 'display_name': 'Jin Yan', 'orcid': 'https://orcid.org/0000-0002-0116-7705'}, 'institutions': [{'id': 'https://openalex.org/I82497590', 'display_name': 'Auburn University', 'ror': 'https://ror.org/02v80fc35', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I82497590']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jin Yan', 'raw_affiliation_strings': ['Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.', 'institution_ids': ['https://openalex.org/I82497590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013605139', 'display_name': 'M. Lamar Seibenhener', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I82497590', 'display_name': 'Auburn University', 'ror': 'https://ror.org/02v80fc35', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I82497590']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Lamar Seibenhener', 'raw_affiliation_strings': ['Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.', 'institution_ids': ['https://openalex.org/I82497590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016459816', 'display_name': 'Luis Calderilla‐Barbosa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I82497590', 'display_name': 'Auburn University', 'ror': 'https://ror.org/02v80fc35', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I82497590']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Luis Calderilla-Barbosa', 'raw_affiliation_strings': ['Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.', 'institution_ids': ['https://openalex.org/I82497590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008277357', 'display_name': 'Marı́a T. Diaz-Meco', 'orcid': 'https://orcid.org/0000-0003-0147-0998'}, 'institutions': [{'id': 'https://openalex.org/I188891513', 'display_name': 'Sanford Burnham Prebys Medical Discovery Institute', 'ror': 'https://ror.org/03m1g2s55', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I188891513']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria-Theresa Diaz-Meco', 'raw_affiliation_strings': ['Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.', 'institution_ids': ['https://openalex.org/I188891513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037329333', 'display_name': 'Jorge Moscat', 'orcid': 'https://orcid.org/0000-0002-9442-3834'}, 'institutions': [{'id': 'https://openalex.org/I188891513', 'display_name': 'Sanford Burnham Prebys Medical Discovery Institute', 'ror': 'https://ror.org/03m1g2s55', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I188891513']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jorge Moscat', 'raw_affiliation_strings': ['Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.', 'institution_ids': ['https://openalex.org/I188891513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063483736', 'display_name': 'Jianxiong Jiang', 'orcid': 'https://orcid.org/0000-0003-3955-8928'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jianxiong Jiang', 'raw_affiliation_strings': ['Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037398931', 'display_name': 'Marie W. Wooten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I82497590', 'display_name': 'Auburn University', 'ror': 'https://ror.org/02v80fc35', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I82497590']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marie W. Wooten', 'raw_affiliation_strings': ['Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.', 'institution_ids': ['https://openalex.org/I82497590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081425117', 'display_name': 'Michael C. Wooten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I82497590', 'display_name': 'Auburn University', 'ror': 'https://ror.org/02v80fc35', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I82497590']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael C. Wooten', 'raw_affiliation_strings': ['Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America.', 'institution_ids': ['https://openalex.org/I82497590']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 5.804, 'has_fulltext': False, 'cited_by_count': 104, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '8', 'issue': '9', 'first_page': 'e76016', 'last_page': 'e76016'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Role of Histone Deacetylases in Cellular Regulation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aggresome', 'display_name': 'Aggresome', 'score': 0.9782963}, {'id': 'https://openalex.org/keywords/hdac6', 'display_name': 'HDAC6', 'score': 0.90316695}, {'id': 'https://openalex.org/keywords/sequestosome-1', 'display_name': 'Sequestosome 1', 'score': 0.8414532}, {'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein Degradation', 'score': 0.499904}, {'id': 'https://openalex.org/keywords/cortactin', 'display_name': 'Cortactin', 'score': 0.46517894}, {'id': 'https://openalex.org/keywords/colocalization', 'display_name': 'Colocalization', 'score': 0.42386904}], 'concepts': [{'id': 'https://openalex.org/C187436293', 'wikidata': 'https://www.wikidata.org/wiki/Q4692265', 'display_name': 'Aggresome', 'level': 4, 'score': 0.9782963}, {'id': 'https://openalex.org/C23681527', 'wikidata': 'https://www.wikidata.org/wiki/Q18034953', 'display_name': 'HDAC6', 'level': 5, 'score': 0.90316695}, {'id': 'https://openalex.org/C2908656506', 'wikidata': 'https://www.wikidata.org/wiki/Q18033497', 'display_name': 'Sequestosome 1', 'level': 4, 'score': 0.8414532}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6944595}, {'id': 'https://openalex.org/C2778305200', 'wikidata': 'https://www.wikidata.org/wiki/Q174378', 'display_name': 'Histone deacetylase', 'level': 4, 'score': 0.57910824}, {'id': 'https://openalex.org/C136238340', 'wikidata': 'https://www.wikidata.org/wiki/Q7251455', 'display_name': 'Protein aggregation', 'level': 2, 'score': 0.5480745}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47817665}, {'id': 'https://openalex.org/C2776000893', 'wikidata': 'https://www.wikidata.org/wiki/Q14906154', 'display_name': 'Cortactin', 'level': 4, 'score': 0.46517894}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.46498367}, {'id': 'https://openalex.org/C40209533', 'wikidata': 'https://www.wikidata.org/wiki/Q5147828', 'display_name': 'Colocalization', 'level': 2, 'score': 0.42386904}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40508187}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.3935193}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22344047}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.192134}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.15113717}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.10024077}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D006655', 'descriptor_name': 'Histone Deacetylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D022101', 'descriptor_name': 'Microtubule-Organizing Center', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D059748', 'descriptor_name': 'Proteolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073864', 'descriptor_name': 'Histone Deacetylase 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006655', 'descriptor_name': 'Histone Deacetylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022101', 'descriptor_name': 'Microtubule-Organizing Center', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025941', 'descriptor_name': 'Protein Interaction Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071456', 'descriptor_name': 'Sequestosome-1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0076016', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076016&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/c7848073d6e94c04b38d2691bed6fb82', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3785417', 'pdf_url': 'https://europepmc.org/articles/pmc3785417?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785417', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24086678', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0076016', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076016&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1904531393', 'https://openalex.org/W1925288097', 'https://openalex.org/W1969342645', 'https://openalex.org/W1979153645', 'https://openalex.org/W1979832500', 'https://openalex.org/W1981549228', 'https://openalex.org/W1984457233', 'https://openalex.org/W1988146888', 'https://openalex.org/W1989140603', 'https://openalex.org/W1989763558', 'https://openalex.org/W1990011854', 'https://openalex.org/W1992027492', 'https://openalex.org/W1998499089', 'https://openalex.org/W2005485591', 'https://openalex.org/W2005845714', 'https://openalex.org/W2012887006', 'https://openalex.org/W2014268728', 'https://openalex.org/W2014918593', 'https://openalex.org/W2019364582', 'https://openalex.org/W2021242983', 'https://openalex.org/W2021996063', 'https://openalex.org/W2026460862', 'https://openalex.org/W2037793441', 'https://openalex.org/W2046746554', 'https://openalex.org/W2059089560', 'https://openalex.org/W2063528655', 'https://openalex.org/W2064959533', 'https://openalex.org/W2067215332', 'https://openalex.org/W2068213179', 'https://openalex.org/W2070835061', 'https://openalex.org/W2072321275', 'https://openalex.org/W2083436950', 'https://openalex.org/W2087961967', 'https://openalex.org/W2090926709', 'https://openalex.org/W2091820232', 'https://openalex.org/W2093402487', 'https://openalex.org/W2094272082', 'https://openalex.org/W2097360510', 'https://openalex.org/W2098089867', 'https://openalex.org/W2101127235', 'https://openalex.org/W2107114877', 'https://openalex.org/W2107561141', 'https://openalex.org/W2109773179', 'https://openalex.org/W2115620208', 'https://openalex.org/W2117298794', 'https://openalex.org/W2125123150', 'https://openalex.org/W2125568224', 'https://openalex.org/W2128151020', 'https://openalex.org/W2128761802', 'https://openalex.org/W2133789233', 'https://openalex.org/W2146124002', 'https://openalex.org/W2148495272', 'https://openalex.org/W2149761960', 'https://openalex.org/W2155768517', 'https://openalex.org/W2160451428', 'https://openalex.org/W2170468070', 'https://openalex.org/W2171155178'], 'related_works': ['https://openalex.org/W2763301729', 'https://openalex.org/W2395542081', 'https://openalex.org/W2365680855', 'https://openalex.org/W2170913652', 'https://openalex.org/W2170290617', 'https://openalex.org/W2148982063', 'https://openalex.org/W2055740754', 'https://openalex.org/W2032007095', 'https://openalex.org/W2005485591', 'https://openalex.org/W1480539518'], 'abstract_inverted_index': {'Protein': [0], 'aggregates': [1, 32, 118], 'can': [2, 135], 'form': [3], 'in': [4, 63, 182, 213, 251], 'the': [5, 8, 17, 48, 68, 121, 174, 186, 208, 253, 260], 'cytoplasm': [6], 'of': [7, 47, 70, 98, 106, 177, 210, 215, 219, 226, 238, 255, 273], 'cell': [9], 'and': [10, 67, 95, 108, 134, 161, 184, 191, 217, 221], 'are': [11, 24, 33, 204], 'accumulated': [12], 'at': [13, 147], 'aggresomes': [14], 'localized': [15], 'to': [16, 60, 79, 92, 110, 144, 153, 259], 'microtubule': [18], 'organizing': [19], 'center': [20], '(MTOC)': [21], 'where': [22], 'they': [23], 'subsequently': [25, 38], 'degraded': [26], 'by': [27, 138], 'autophagy.': [28], 'In': [29], 'this': [30, 165, 197], 'process,': [31], 'engulfed': [34], 'into': [35], 'autophagosomes': [36, 71], 'which': [37], 'fuse': [39], 'with': [40, 72, 120, 141, 159], 'lysosomes': [41, 73], 'for': [42, 131, 235, 269], 'protein': [43, 81, 85, 99, 117, 139, 149, 227, 274], 'degradation.': [44], 'A': [45], 'member': [46], 'class': [49], 'II': [50], 'histone': [51, 54], 'deacetylase': [52, 55, 127, 201], 'family,': [53], '6(HDAC6)': [56], 'has': [57, 88], 'been': [58, 90], 'shown': [59, 91], 'be': [61, 136], 'involved': [62], 'both': [64], 'aggresome': [65, 132], 'formation': [66, 133], 'fusion': [69], 'making': [74], 'it': [75], 'an': [76], 'attractive': [77], 'target': [78], 'regulate': [80, 93], 'aggregation.': [82], 'The': [83], 'scaffolding': [84], 'sequestosome': [86], '1(SQSTM1)/p62': [87], 'also': [89], 'accumulation': [94], 'autophagic': [96, 271], 'clearance': [97, 272], 'aggregates.': [100, 275], 'Recent': [101], 'studies': [102], 'have': [103], 'revealed': [104], 'colocalization': [105, 146], 'HDAC6': [107, 126, 160, 171, 190, 200, 216], 'p62': [109, 156, 211, 232, 246], 'ubiquitinated': [111, 116, 148], 'mitochondria,': [112], 'as': [113], 'well': [114], 'as,': [115], 'associated': [119], 'E3': [122], 'ubiquitin': [123], 'ligase': [124], 'TRIM50.': [125], 'activity': [128, 172], 'is': [129, 233, 267], 'required': [130, 234, 268], 'regulated': [137], 'interaction': [140, 166, 188, 198], 'HDAC6.': [142], 'Due': [143], 'their': [145], 'aggregates,': [150], 'we': [151, 229], 'sought': [152], 'examine': [154], 'if': [155, 162, 164], 'specifically': [157], 'interacted': [158], 'so,': [163], 'had': [167], 'any': [168], 'effect': [169], 'on': [170], 'and/or': [173], 'physiological': [175], 'function': [176, 265], 'cortactin-F-actin': [178, 239], 'assembly.': [179], 'We': [180, 193], 'succeeded': [181], 'identifying': [183], 'mapping': [185], 'direct': [187], 'between': [189], 'p62.': [192], 'further': [194], 'show': [195, 230], 'that': [196, 207, 231, 245, 266], 'regulates': [199], 'activity.': [202], 'Data': [203], 'presented': [205], 'demonstrating': [206], 'absence': [209], 'results': [212], 'hyperactivation': [214], 'deacetylation': [218], 'α-tubulin': [220], 'cortactin.': [222], 'Further,': [223], 'upon': [224], 'induction': [225], 'misfolding': [228], 'perinuclear': [236], 'co-localization': [237], 'assemblies.': [240], 'Thus,': [241], 'our': [242], 'findings': [243], 'indicate': [244], 'plays': [247], 'a': [248, 262], 'key': [249], 'role': [250], 'regulating': [252], 'recruitment': [254], 'F-actin': [256], 'network': [257], 'assemblies': [258], 'MTOC,': [261], 'critical': [263], 'cellular': [264], 'successful': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2055740754', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-18T03:21:34.139795', 'created_date': '2016-06-24'}