Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 Integrase

Name: Work Video:
Duration: 3 min 30 s
Manuel Llano; Sharon Delgado; Maria Vanegas; Eric M. Poeschla
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2382, 2402, 2413, 2471, 2625, 2816, 2824, 2915, 2936, 3019, 3060, 3093, 3137, 3173, 3255, 3324, 3338, 3367, 3445, 3489, 3549, 3783, 3794, 3847, 3851, 3908, 3931, 3940, 3996, 4031, 4038, 4070, 4086, 4092, 4112, 4136, 4149, 4161, 4212, 4291, 4379, 4399, 4422], 'much': [64, 119, 325, 380, 825, 3757, 4159], 'lower': [65, 326, 3758, 3816, 3840, 3901, 3921, 4033, 4082], 'steady': [66, 327, 2325, 3606, 3759, 3817, 3902, 3943, 4034], 'state': [67, 328, 2326, 3607, 3760, 3818, 3903, 3944, 4035], 'levels': [68, 93, 134, 329, 354, 395, 2086, 2327, 3761, 3819, 3841, 3904, 3928, 3945, 3956, 4037, 4085, 4138, 4177, 4228, 4254, 4366], 'IN': [70, 91, 113, 132, 152, 161, 179, 186, 205, 223, 232, 331, 352, 374, 393, 413, 422, 440, 447, 466, 484, 493, 876, 1039, 1151, 1249, 2009, 2036, 2078, 2332, 2357, 2367, 2665, 2700, 2712, 2744, 2752, 3136, 3216, 3272, 3486, 3557, 3592, 3608, 3614, 3633, 3766, 3823, 3844, 3855, 3906, 3922, 3926, 3941, 3954, 3981, 4036, 4083, 4122, 4142, 4167, 4220, 4253, 4323, 4329, 4347, 4368, 4375, 4391, 4395, 4408, 4418, 4461, 4469], 'protein': [71, 114, 133, 332, 375, 394, 1688, 2038, 2377, 2420, 3226, 3824, 3942, 4025, 4084, 4462], 'than': [72, 210, 333, 471, 821, 2386, 2872, 3768, 3825, 3850, 4091, 4369, 4414], 'LEDGF/p75': [75, 139, 166, 172, 197, 336, 400, 427, 433, 458, 814, 1156, 1161, 1206, 1309, 1358, 2318, 2342, 2359, 2370, 2390, 2502, 2776, 3316, 3777, 3871, 4108, 4262, 4457], 'wild': [76, 140, 198, 337, 401, 459, 549, 593, 2393], 'cells.': [78, 123, 168, 339, 384, 429, 1158, 1572, 4040], 'same': [80, 341, 748, 3990], 'LEDGF/p75-dependent': [81, 342], 'disparity': [82, 343], 'was': [83, 106, 115, 162, 344, 367, 376, 423, 1207, 2039, 2051, 2447, 2489, 2618, 2823, 2962, 2985, 3005, 3293, 3317, 3412, 3487, 3500, 3514, 3547, 3594, 3621, 3779, 3856, 3920, 4158, 4208, 4222, 4376, 4392, 4396], 'feline': [86, 347, 545, 589, 1147], 'IN.': [89, 213, 350, 474, 4301], 'However,': [90, 214, 351, 475, 1585, 1736, 2076], 'mRNA': [92, 353, 2336, 3923, 3927, 3955], 'were': [94, 355, 2538, 2659, 2683, 2707, 2810, 2829, 2850, 2876, 2886, 2929, 2969, 2990, 3017, 3053, 3058, 3091, 3106, 3150, 3161, 3171, 3194, 3238, 3263, 3333, 3365, 3424, 3443, 3458, 3523, 3569, 3655, 3706, 3845, 3929, 3965, 3987, 4042, 4307, 4317, 4348, 4385], 'equivalent': [95, 356, 2335, 3930, 3953], 'presence': [98, 359, 3998], 'absence': [100, 361, 895, 2193, 4072], 'LEDGF/p75.': [102, 363, 2395], 'A': [103, 364, 2034, 3227, 4335], 'post-translational': [104, 365], 'mechanism': [105, 366], 'confirmed': [107, 368, 1364, 4075], 'when': [108, 369, 891, 3313, 3854, 4382, 4428], 'half-life': [110, 209, 371, 470], 'found': [116, 163, 377, 424, 4420], 'to': [117, 135, 173, 378, 396, 434, 889, 1035, 1042, 1050, 1053, 1177, 1210, 1246, 1319, 1365, 1578, 1589, 1874, 2013, 2042, 2123, 2128, 2183, 2344, 2410, 2450, 2763, 2802, 2878, 3099, 3134, 3203, 3225, 3438, 3553, 3596, 3623, 3873, 3898, 4170, 4465], 'be': [118, 379, 1043, 1211, 1366, 1579, 1875, 2043, 2080, 4147, 4471], 'shorter': [120, 208, 381, 469], 'Proteasome': [124, 385, 4266], 'inhibition': [125, 386, 2055, 4245], 'fully': [126, 387], 'countered': [127, 388], 'this': [128, 389, 1313, 2006, 2694, 4264], 'extreme': [129, 390], 'instability,': [130, 391], 'increasing': [131, 392], 'those': [136, 397, 3937], 'seen': [137, 398], 'implicating': [144, 405], 'proteasomal': [145, 406, 2349], 'destruction': [146, 407], 'main': [149, 410], 'cause': [150, 411], 'instability.': [153, 414], 'Consistent': [154, 415], 'these': [156, 417, 2804, 2839], 'data,': [157, 418], 'increased': [158, 419, 4169], 'ubiquitinated': [159, 420, 4341, 4374, 4394], 'knock-down': [167, 428, 4109], 'Moreover,': [169, 430, 4226], 'restoration': [170, 431], 'knocked': [174, 435, 2315, 2415], 'down': [175, 436, 2316, 2416], 'clones': [176, 437, 2849, 2866, 3423, 3799, 3813, 4296, 4357], 'rescued': [177, 438], 'stability.': [180, 441], 'Subcellular': [181, 442], 'fractionation': [182, 443], 'showed': [183, 444, 2340], 'is': [187, 251, 448, 512, 616, 733, 815, 824, 1317, 1576, 1665, 1745, 2090, 2732, 3872, 4019, 4419], 'exclusively': [188, 449, 4421], 'cytoplasmic': [189, 203, 450, 464, 3453], 'cells,': [192, 200, 453, 461, 2048, 2691, 3703, 3750, 3935, 4215, 4459], 'but': [193, 454, 1594, 2360, 4155], 'mainly': [194, 455], 'has': [206, 467, 1032, 1362, 2010, 2759], 'using': [215, 476, 3268, 3319], 'LEDGF': [216, 477, 755], 'proteins': [217, 478, 756, 877, 899, 1040, 1152, 1173, 1372, 1610, 1978, 2120, 2137, 3262, 3292, 3593, 3767, 3907, 4168, 4221, 4232, 4384], 'defective': [218, 479], 'interaction,': [224, 485], 'further': [226, 487, 2660], 'determined': [227, 488, 4256], 'protection': [229, 490], 'from': [233, 494, 1174, 2348, 2492, 2620, 2686, 2831, 2867, 3516, 3657, 3709, 4172, 4269, 4351], 'proteasome': [235, 496, 1650, 1720, 1738, 1916, 1960, 1971, 2054, 2126, 2146, 2182, 2305, 2380, 4018, 4046, 4191, 4244, 4258], 'requires': [236, 244, 497, 505, 2354], 'neither': [237, 498], 'nor': [240, 501], 'residence.': [242, 503], 'Protection': [243, 504], 'only': [245, 506, 3538], 'interaction': [246, 507, 1316, 2355, 2368, 2774], 'LEDGF/p75,': [248, 509, 731, 4240], 'it': [250, 511, 823], 'independent': [252, 513], 'subcellular': [255, 516, 2627, 2770, 3492], 'IN-LEDGF': [259, 520], 'complex.': [260, 521, 2366], 'Lens': [522], '(LEDGF/p75)': [526], '1The': [527], 'abbreviations': [528, 572], 'used': [529, 573, 2449, 2972, 3548, 3570, 3595, 3622], 'are:': [530, 574], 'LEDGF,': [531, 575], 'factor;': [535, 579], 'IN,': [536, 580], 'integrase;': [537, 581], 'HIV-1,': [538, 582, 1861], '1;': [543, 587], 'FIV,': [544, 588], 'virus;': [547, 591], 'WT,': [548, 592], 'type;': [550, 594], 'Ub,': [551, 595], 'ubiquitin;': [552, 596], 'shRNA,': [553, 597], 'short': [554, 598, 1710, 2404], 'hairpin': [555, 599, 2405], 'RNA;': [556, 600], 'RNAi,': [557, 601, 2320], 'RNA': [558, 602, 2406, 3511, 3573], 'interference;': [559, 603], 'RT,': [560, 604], 'reverse': [561, 605, 2211, 3540], 'transcriptase;': [562, 606], 'mAb,': [563, 607], 'monoclonal': [564, 608, 3115, 3278], 'antibody;': [565, 609], 'NLS,': [566, 610], 'signal;': [569, 613], 'HA,': [570, 614], 'hemagglutinin.1The': [571], 'hemagglutinin.': [615], 'interacts': [621], 'general': [624], 'machinery': [626], '(1Ge': [627, 776, 3879], 'H.': [628, 644, 777, 793, 1017, 3468, 3880], 'Si': [629, 778, 794, 3881], 'Y.': [630, 779, 795, 855, 1013, 1092, 1128, 1288, 1387, 1761, 2274, 2521, 3882], 'Roeder': [631, 645, 780, 3883], 'R.G.': [632, 646, 781, 3884], 'EMBO': [633, 782, 1622, 1791, 3885], 'J.': [634, 783, 844, 857, 914, 1000, 1020, 1070, 1090, 1098, 1129, 1194, 1232, 1264, 1289, 1335, 1388, 1465, 1494, 1496, 1498, 1522, 1537, 1554, 1623, 1792, 1806, 1997, 2023, 2060, 2108, 2171, 2435, 2522, 2590, 2644, 2791, 3688, 3736, 3886, 4446], '1998;': [635, 784, 800, 1624, 1639, 1728, 1999, 2173, 3887], '17:': [636, 785, 1625, 3888], '6723-6729Crossref': [637, 786, 3889], 'PubMed': [638, 654, 692, 710, 726, 787, 808, 849, 871, 919, 942, 962, 989, 1005, 1025, 1075, 1109, 1140, 1199, 1237, 1269, 1300, 1340, 1399, 1434, 1454, 1474, 1502, 1526, 1543, 1565, 1627, 1642, 1731, 1780, 1796, 1823, 1841, 1856, 1908, 1952, 2002, 2029, 2071, 2113, 2176, 2224, 2242, 2266, 2289, 2440, 2484, 2533, 2595, 2649, 2796, 3481, 3693, 3741, 3890, 4203, 4286, 4451], 'Scopus': [639, 655, 693, 711, 727, 788, 809, 850, 872, 920, 943, 963, 990, 1006, 1026, 1076, 1110, 1141, 1200, 1238, 1270, 1301, 1341, 1400, 1435, 1455, 1503, 1527, 1544, 1566, 1628, 1643, 1732, 1781, 1797, 1824, 1842, 1857, 1909, 1953, 2030, 2072, 2114, 2225, 2243, 2267, 2290, 2441, 2485, 2534, 2596, 2650, 2797, 3482, 3694, 3742, 3891, 4204, 4287, 4452], '(255)': [640, 789, 3892], 'Google': [641, 657, 695, 713, 729, 790, 811, 852, 874, 922, 945, 965, 992, 1008, 1028, 1078, 1112, 1143, 1202, 1240, 1272, 1303, 1343, 1402, 1437, 1457, 1475, 1505, 1529, 1546, 1568, 1630, 1645, 1734, 1783, 1799, 1826, 1844, 1859, 1911, 1955, 2003, 2032, 2074, 2116, 2177, 2227, 2245, 2269, 2292, 2443, 2487, 2536, 2598, 2652, 2799, 3484, 3696, 3744, 3893, 4206, 4289, 4454], 'Scholar,': [642, 696, 714, 791, 853, 923, 946, 966, 993, 1009, 1079, 1113, 1273, 1458, 1476, 1506, 1530, 1547, 1631, 1784, 1800, 1827, 1845, 2228, 2246, 2270], '2Ge': [643], 'Cell.': [647, 799, 1449, 1814, 1832, 2257, 4198], '1994;': [648, 1468], '78:': [649, 847, 917, 1073, 1197, 1235, 1267, 1338, 2111, 2438, 2593, 2647, 2794, 3691, 3739, 4449], '513-523Abstract': [650], 'Full': [651, 803, 805, 1104, 1106, 1135, 1137, 1295, 1297, 1394, 1396, 1471, 1560, 1562, 1818, 1820, 1836, 1838, 2066, 2068, 2261, 2263, 2528, 2530], 'Text': [652, 804, 806, 1105, 1107, 1136, 1138, 1296, 1298, 1395, 1397, 1472, 1561, 1563, 1819, 1821, 1837, 1839, 2067, 2069, 2262, 2264, 2529, 2531], 'PDF': [653, 807, 1108, 1139, 1299, 1398, 1473, 1564, 1822, 1840, 2070, 2265, 2532], '(307)': [656], 'Scholar).': [658, 730, 875, 1029, 1144, 1203, 1241, 1403, 1646, 1735, 1860, 1912, 1956, 2004, 2033, 2075, 2117, 2178, 2293, 2444, 2599, 2653, 2800, 3485, 3894, 4455], 'Roles': [659], 'regulator': [662, 4023], 'cellular': [664, 2185, 3603, 4315], 'stress': [665], 'responses': [666], 'an': [669, 1668, 2308, 2372, 2375, 2383, 2711, 2717, 3275, 4020], 'autoantigen': [670], 'have': [671, 746, 757, 1871, 2764], 'been': [672, 1033, 1363, 1872, 2011, 2761], 'proposed': [673], '(3Sharma': [674], 'P.': [675, 925, 950, 970, 1081, 1085, 1117, 1277, 1376, 1425, 1478, 1790, 2282, 2510], 'Singh': [676, 699, 858], 'D.P.': [677, 700, 859], 'Fatma': [678, 701], 'N.': [679, 702], 'Chylack': [680, 860], 'Jr.,': [681, 861], 'L.T.': [682, 862], 'Shinohara': [683, 863], 'T.': [684, 698, 718, 864, 927, 1765, 1771], 'Biochem.': [685, 1430, 1497, 1521, 1638, 1727, 1851], 'Biophys.': [686, 1852], 'Res.': [687, 706, 867, 985], 'Commun.': [688], '2000;': [689, 986, 1002, 1499, 1815, 1833, 1905, 1949, 2063, 4200], '276:': [690], '1320-1324Crossref': [691], '(61)': [694], '4Shinohara': [697], 'Prog.': [703], 'Retin.': [704], 'Eye': [705], '2002;': [707], '21:': [708], '341-358Crossref': [709], '(136)': [712], '5Ganapathy': [715], 'V.': [716, 1990], 'Daniels': [717], 'Casiano': [719], 'C.A.': [720], 'Autoimmun.': [721], 'Rev.': [722, 1429, 1447, 1637, 1726], '2003;': [723, 1022, 1101, 1132, 1292, 1391, 1451, 1793, 1853, 2026, 2221, 2239, 2258, 2286, 2525], '2:': [724, 801], '290-297Crossref': [725], '(66)': [728], 'which': [732, 1744, 2758, 3713], '530': [734], 'amino': [735, 751, 763, 772, 2460], 'acids': [736, 764, 773, 2461], 'length,': [738], 'LEDGF/p52,': [740, 822], '333-amino': [742], 'acid': [743, 1308, 1662], 'splice': [744], 'variant,': [745], 'N-terminal': [749], '325': [750], 'acids.': [752], 'two': [754], 'wholly': [758], 'different': [759], 'C': [760, 1310, 1674, 3111, 3435], 'termini': [761], '(8': [762], 'case': [767], 'p52': [769], 'versus': [770, 4128], '205': [771], 'p75': [775], '6Ge': [792], 'Wolffe': [796], 'A.P.': [797], 'Mol.': [798, 1448, 1813, 2256, 4197], '751-759Abstract': [802], '(122)': [810], 'Scholar)).': [812], 'Although': [813, 4361], 'less': [816], 'active': [817, 1417], 'more': [826, 1702, 4210, 4237, 4377], 'abundant': [827, 4211, 4378], '(7Llano': [830, 900, 1056, 1180, 1218, 1250, 1321, 2094, 2421, 2576, 2630, 2777, 3674, 3722, 4432], 'M.': [831, 833, 841, 901, 903, 911, 1057, 1059, 1067, 1181, 1183, 1191, 1219, 1221, 1229, 1251, 1253, 1261, 1322, 1324, 1332, 1443, 1786, 1808, 1847, 2095, 2097, 2105, 2166, 2230, 2422, 2424, 2432, 2477, 2577, 2579, 2587, 2631, 2633, 2641, 2778, 2780, 2788, 3466, 3675, 3677, 3685, 3723, 3725, 3733, 4279, 4433, 4435, 4443], 'Vanegas': [832, 902, 1058, 1182, 1220, 1252, 1323, 2096, 2423, 2578, 2632, 2779, 3676, 3724, 4434], 'Fregoso': [834, 904, 1060, 1184, 1222, 1254, 1325, 2098, 2425, 2580, 2634, 2781, 3678, 3726, 4436], 'O.': [835, 905, 997, 1061, 1185, 1223, 1255, 1326, 1988, 2099, 2426, 2581, 2635, 2782, 3679, 3727, 4437], 'Saenz': [836, 906, 1062, 1186, 1224, 1256, 1327, 2100, 2427, 2582, 2636, 2783, 3680, 3728, 4438], 'D.': [837, 907, 929, 931, 952, 978, 1063, 1187, 1225, 1257, 1328, 1423, 2101, 2236, 2428, 2479, 2493, 2583, 2637, 2784, 3681, 3729, 4281, 4439], 'Chung': [838, 908, 1064, 1188, 1226, 1258, 1329, 2102, 2429, 2584, 2638, 2785, 3682, 3730, 4440], 'S.': [839, 909, 937, 982, 1065, 1189, 1227, 1259, 1330, 1484, 1512, 1763, 1767, 1849, 1903, 1947, 2103, 2162, 2430, 2585, 2639, 2786, 3476, 3683, 3731, 4441], 'Peretz': [840, 910, 1066, 1190, 1228, 1260, 1331, 2104, 2431, 2586, 2640, 2787, 3684, 3732, 4442], 'Poeschla': [842, 912, 1068, 1192, 1230, 1262, 1333, 2106, 2433, 2588, 2642, 2789, 3471, 3686, 3734, 4444], 'E.M.': [843, 913, 1069, 1193, 1231, 1263, 1334, 2107, 2434, 2589, 2643, 2790, 3472, 3687, 3735, 4445], 'Virol.': [845, 915, 1001, 1021, 1071, 1195, 1233, 1265, 1336, 1998, 2109, 2172, 2436, 2591, 2645, 2792, 3689, 3737, 4447], '2004;': [846, 916, 1072, 1196, 1234, 1266, 1337, 2110, 2437, 2592, 2646, 2793, 3478, 3690, 3738, 4448], '9524-9537Crossref': [848, 918, 1074, 1198, 1236, 1268, 1339, 2112, 2439, 2594, 2648, 2795, 3692, 3740, 4450], '(258)': [851, 921, 1077, 1201, 1239, 1271, 1342, 2115, 2442, 2597, 2651, 2798, 3695, 3743, 4453], '8Nishizawa': [854], 'Usukura': [856], 'Cell': [865, 984, 2024, 2547, 2560, 3577], 'Tissue': [866], '2001;': [868], '305:': [869], '107-114Crossref': [870], '(72)': [873, 964], 'other': [886, 897, 4230], 'lentiviruses': [887], 'localize': [888], 'nuclei': [890], 'expressed': [892, 2081, 3756, 3857, 4273], 'viral': [898, 2150, 2208], '9Gallay': [924], 'Hope': [926], 'Chin': [928], 'Trono': [930], 'Proc.': [932, 1898, 1942], 'Natl.': [933, 1899, 1943], 'Acad.': [934, 1900, 1944], 'Sci.': [935, 1901, 1945, 2025], 'U.': [936, 1881, 1889, 1902, 1946, 2154], 'A.': [938, 1508, 1534, 1621, 1633, 1635, 1722, 1724, 1775, 1904, 1935, 1948, 2020], '1997;': [939, 2481, 4283], '94:': [940], '9825-9830Crossref': [941], '(415)': [944], '10Pluymers': [947], 'W.': [948, 1119, 1279, 1378, 1427, 2253, 2280, 2512], 'Cherepanov': [949, 1116, 1276, 1375, 2509], 'Schols': [951], 'De': [953, 1093, 1122, 1282, 1381, 2515], 'Clercq': [954, 1094, 1123, 1283, 1382, 2516], 'E.': [955, 1095, 1124, 1284, 1383, 1486, 1520, 1536, 2018, 2517, 3470], 'Debyser': [956, 1096, 1125, 1285, 1384, 2518, 2543], 'Z.': [957, 1097, 1126, 1286, 1385, 2519, 2542], 'Virology.': [958, 3477], '1999;': [959, 1431, 1557], '258:': [960], '327-332Crossref': [961], '11Depienne': [967], 'C.': [968, 972, 980, 995, 2251, 3235], 'Roques': [969], 'Creminon': [971], 'Fritsch': [973], 'L.': [974], 'Casseron': [975], 'R.': [976, 1829, 1887], 'Dormont': [977], 'Dargemont': [979], 'Benichou': [981], 'Exp.': [983], '260:': [987], '387-395Crossref': [988], '(91)': [991], '12Petit': [994], 'Schwartz': [996], 'Mammano': [998], 'F.': [999, 1994], '74:': [1003], '7119-7126Crossref': [1004], '(79)': [1007], '13Woodward': [1010], 'C.L.': [1011], 'Wang': [1012], 'Dixon': [1014], 'W.J.': [1015], 'Htun': [1016], 'Chow': [1018], 'S.A.': [1019, 1553], '77:': [1023], '4516-4527Crossref': [1024], '(17)': [1027], 'Recently,': [1030], 'LEDFG/p75': [1031], 'shown': [1034, 1209, 1873, 2012, 2762], 'interact': [1036, 1247], 'lentiviral': [1038, 1171, 1215, 2346, 2696, 3632, 4141, 4166], 'directly,': [1041], 'required': [1044], 'their': [1046, 1352], 'targeting,': [1048], 'tether': [1051], 'them': [1052], '14Cherepanov': [1080], 'Maertens': [1082], 'G.': [1083, 1115, 1275, 1374, 1480, 1518, 1939, 2508], 'Proost': [1084], 'Devreese': [1086], 'B.': [1087, 1933, 1992, 2276], 'Van': [1088], 'Beeumen': [1089], 'Engelborghs': [1091, 1127, 1287, 1386, 2520], 'Biol.': [1099, 1130, 1290, 1389, 1450, 1466, 1555, 2061, 2523, 4199], 'Chem.': [1100, 1131, 1291, 1390, 1467, 1556, 2062, 2524], '278:': [1102, 1133, 1293, 1392, 2526], '372-381Abstract': [1103], '(572)': [1111], '15Maertens': [1114, 1274], 'Pluymers': [1118, 1278, 1377, 2511], 'Busschots': [1120, 1280, 1379, 2513], 'K.': [1121, 1281, 1380, 1492, 1769, 1773, 2168, 2248, 2278, 2514, 3474], '33528-33539Abstract': [1134, 1294, 1393, 2527], '(419)': [1142, 1302, 1401, 2535], '(FIV)': [1150], 'precisely': [1153], 'colocalize': [1154], 'against': [1160], 'produces': [1162], 'strikingly': [1164], 'complete': [1165], 'shift': [1168], 'both': [1170, 1419, 3782, 3980, 4140, 4150, 4165, 4352, 4359, 4400], 'nucleus': [1176, 1441], 'cytoplasm': [1179, 1421, 4424], 'In': [1204, 1647, 2005, 2191, 2311, 2746, 3838, 4456], 'addition,': [1205, 2747, 3839], 'also': [1208, 1740, 1964, 2040, 2684, 3006, 3707, 3988, 4105, 4209], 'component': [1213], 'preintegration': [1216], 'complexes': [1217], 'failure': [1243], 'LEDGF/p52': [1245, 2504], 'Scholar)': [1304, 1344, 1438, 1569, 2488, 2537, 4290], 'implicates': [1305], '205-amino': [1307], 'terminus': [1311, 1675], 'specific': [1318, 2131, 3559], 'lentiretroviruses': [1320], 'suggesting': [1345, 1968], 'possibility': [1347, 3897], 'role': [1350, 3869, 4030], 'distinctive': [1353], 'biological': [1354], 'features.': [1355], 'Association': [1356], 'between': [1357, 1672], 'direct': [1367], 'experiments': [1369], 'recombinant': [1371], '(15Maertens': [1373, 2507], '26': [1404], 'S': [1405, 1715, 2657, 2690, 3039, 3720, 3852, 4153], 'proteasomes': [1406], 'are': [1407, 1652, 1705, 1755, 2121, 2754, 3957, 4255], 'multicatalytic,': [1408], 'multisubunit': [1409], 'proteases': [1410], 'comprise': [1412], 'major': [1414], 'protein-degrading': [1415], 'apparatus': [1416], '(16Voges': [1422], 'Zwickl': [1424], 'Baumeister': [1426], 'Annu.': [1428, 1636, 1725], '68:': [1432], '1015-1068Crossref': [1433], '(1592)': [1436], '(17Muratani': [1442], 'Tansey': [1444], 'W.P.': [1445], 'Nat.': [1446, 2219, 2237], '4:': [1452], '192-201Crossref': [1453], '(674)': [1456], '18Peters': [1459], 'J.M.': [1460, 1810, 1996], 'Franke': [1461], 'W.W.': [1462], 'Kleinschmidt': [1463], 'J.A.': [1464], '269:': [1469], '7709-7718Abstract': [1470], '19Brooks': [1477], 'Fuertes': [1479, 1517], 'Murray': [1481], 'R.Z.': [1482], 'Bose': [1483], 'Knecht': [1485, 1519, 1535], 'Rechsteiner': [1487], 'M.C.': [1488], 'Hendil': [1489, 1513], 'K.B.': [1490, 1514], 'Tanaka': [1491, 1772], 'Dyson': [1493], 'Rivett': [1495, 1509], '346:': [1500], '155-161Crossref': [1501], '(259)': [1504], '20Palmer': [1507], 'A.J.': [1510, 1532], 'Thomson': [1511], 'Butcher': [1515], 'G.W.': [1516], '1996;': [1523], '316:': [1524], '401-407Crossref': [1525], '(154)': [1528], '21Rivett': [1531], 'Palmer': [1533], 'Histochem.': [1538], 'Cytochem.': [1539], '1992;': [1540, 1777], '40:': [1541], '1165-1172Crossref': [1542], '(127)': [1545], '22Russell': [1548], 'S.J.': [1549], 'Steger': [1550], 'K.A.': [1551], 'Johnston': [1552], '274:': [1558], '21943-21952Abstract': [1559], '(152)': [1567], 'eukaryotic': [1571], 'This': [1573, 2445, 3776, 4144], 'selective': [1574], 'system': [1575, 2127, 2306, 3532], 'known': [1577, 2122, 4188], 'essential': [1580], 'degrading': [1582], 'misfolded': [1583], 'proteins.': [1584, 4143], 'scope': [1587], 'extends': [1588], 'fast': [1590], 'turnover': [1591], 'normal': [1593, 3868], 'short-lived': [1595], 'key': [1596], 'regulatory': [1597], 'proteins,': [1598, 3604], 'e.g.': [1599], 'regulators': [1601], '(Jun,': [1602], 'Fos,': [1603], 'p53,': [1604], 'IκB-NFκB,': [1605], 'MyoD,': [1606], 'c-Myc),': [1607], 'cell': [1608, 2135, 2312, 2673, 2884, 2988, 3192, 3456, 3520, 3617, 3659, 3788, 3812, 3836, 3963, 4295, 4356], 'cycle': [1609], '(cyclins,': [1611], 'p21Cip1),': [1612], 'rate-limiting': [1614], 'metabolic': [1615], 'pathway': [1616], 'enzymes': [1617], '(ornithine': [1618], 'decarboxylase)': [1619], '(23Ciechanover': [1620], '7151-7160Crossref': [1626], '(1192)': [1629], '24Hershko': [1632], 'Ciechanover': [1634, 1723], '67:': [1640, 1729], '425-479Crossref': [1641, 1730], '(6880)': [1644, 1733], 'most': [1648, 1747, 3938], 'cases,': [1649], 'substrates': [1651], 'modified': [1653, 3021], 'covalent': [1655], 'attachment': [1656], 'ubiquitin': [1658, 4275], '(Ub),': [1659], '76-amino': [1661], 'polypeptide.': [1663], 'Ub': [1664, 1694, 1703], 'bound': [1666], 'through': [1667, 3615, 4115], 'isopeptide': [1669], 'link': [1670], 'established': [1671, 2852], 'ϵ-NH2': [1678], 'groups': [1679], 'lysine': [1681], 'residues': [1682], 'present': [1683, 2295], 'either': [1684, 2768], 'on': [1685, 1690, 2767, 4219], 'target': [1687, 1962, 1973, 2408, 4189], 'or': [1689, 1701, 1976, 2459, 2772, 2908, 2946, 2971, 2976, 3130, 3211, 3274, 3305, 3396, 3402, 3452, 3491, 3518, 3636, 3671, 3719, 3771, 4174, 4322], 'previously': [1692, 2760, 3462, 3661], 'attached': [1693], 'molecule.': [1695], 'Proteins': [1696, 3088, 3585], 'oligomers': [1698], 'four': [1700, 2840, 3785], 'molecules': [1704], 'targeted': [1706], 'degradation': [1708, 1739, 2016, 2132, 2147, 2381, 4015, 4192, 4259], 'peptides': [1711], '20': [1714, 3376], 'catalytic': [1716], 'subunit': [1717], '(24Hershko': [1721], 'ubiquitin-independent': [1737, 1758], 'occurs.': [1741], 'Ornithine': [1742], 'transcarbamylase,': [1743], 'rapidly': [1748], 'turned': [1749], 'over': [1750], 'mammalian': [1751], 'enzyme,': [1752], 'p21cip1': [1754], 'among': [1756], 'exceptions': [1759], '(25Murakami': [1760], 'Matsufuji': [1762], 'Kameji': [1764], 'Hayashi': [1766], 'Igarashi': [1768], 'Tamura': [1770], 'Ichihara': [1774], 'Nature.': [1776], '360:': [1778], '597-599Crossref': [1779], '(670)': [1782], '26Zhang': [1785], 'Pickart': [1787], 'C.M.': [1788], 'Coffino': [1789], '22:': [1794], '1488-1496Crossref': [1795], '(180)': [1798], '27Sheaff': [1801], 'R.J.': [1802, 1831], 'Singer': [1803], 'J.D.': [1804], 'Swanger': [1805], 'Smitherman': [1807], 'Roberts': [1809], 'Clurman': [1811], 'B.E.': [1812], '5:': [1816], '403-410Abstract': [1817], '(360)': [1825], '28Verma': [1828], 'Deshaies': [1830], '101:': [1834], '341-344Abstract': [1835], '(119)': [1843], '29Orlowski': [1846], 'Wilk': [1848], 'Arch.': [1850], '415:': [1854], '1-5Crossref': [1855], '(186)': [1858], 'simian': [1862], 'virus,': [1864], 'Moloney': [1866], 'murine': [1867], 'leukemia': [1868], 'Gag': [1870, 1920], 'monoubiquitinated': [1876], 'virion': [1879, 1928, 2200], '(30Schubert': [1880], 'Ott': [1882], 'D.E.': [1883], 'Chertova': [1884], 'E.N.': [1885], 'Welker': [1886], 'Tessmer': [1888], 'Princiotta': [1890], 'M.F.': [1891], 'Bennink': [1892, 2163], 'J.R.': [1893, 2164], 'Krausslich': [1894], 'H.G.': [1895, 1941], 'Yewdell': [1896, 2169], 'J.W.': [1897, 2170], '97:': [1906, 1950], '13057-13062Crossref': [1907], '(309)': [1910], 'Inhibition': [1913, 1957], 'interferes': [1917], 'processing': [1921], 'Rous': [1925], 'sarcoma': [1926], 'release': [1929], 'maturation': [1931], '(31Strack': [1932], 'Calistri': [1934], 'Accola': [1936], 'M.A.': [1937, 2059, 4194], 'Palu': [1938], 'Gottlinger': [1940], '13063-13068Crossref': [1951], '(281)': [1954], 'enhances': [1965], 'infectivity,': [1967], 'may': [1972], 'incoming': [1974], 'virions': [1975], 'host': [1977, 2136, 4231], 'involved': [1979], 'early': [1982, 2737], 'steps': [1983], 'infection': [1986], '(32Schwartz': [1987], 'Marechal': [1989], 'Friguet': [1991], 'Arenzana-Seisdedos': [1993], 'Heard': [1995], '72:': [2000, 2174], '3845-3850Crossref': [2001], 'regard,': [2007], 'undergo': [2014], 'proteasome-mediated': [2015], '(33Devroe': [2017], 'Engelman': [2019], 'Silver': [2021], 'P.A.': [2022], '116:': [2027], '4401-4408Crossref': [2028], '(56)': [2031], 'ubiquitin-HIV-1': [2035], 'fusion': [2037], 'demonstrated': [2041], 'unstable': [2044], 'transiently': [2046, 3000, 4272], 'transfected': [2047, 2662, 2930, 3001], 'stability': [2050], 'enhanced': [2052], '(34Mulder': [2056], 'L.C.': [2057, 2156], 'Muesing': [2058], '275:': [2064, 2482, 4284], '29749-29753Abstract': [2065], '(84)': [2073], 'can': [2079, 4470], 'at': [2084, 2812, 2832, 2941, 2951, 3109, 3233, 3344, 3360, 3383, 3433, 3971], 'high': [2085], 'provided': [2087, 2540], 'Rev': [2088], 'dependence': [2089, 3778], 'taken': [2091], 'account': [2093], 'encoded': [2119], 'manipulate': [2124], 'bring': [2129], 'about': [2130], 'producer': [2134], 'inhibit': [2139], 'production': [2140], 'infectious': [2142], 'virus.': [2143], 'Vpu': [2144], 'triggers': [2145], 'receptor': [2151], 'CD4': [2152], '(35Schubert': [2153], 'Anton': [2155], 'Bacik': [2157], 'I.': [2158], 'Cox': [2159], 'J.H.': [2160], 'Bour': [2161, 3475], 'Orlowski': [2165], 'Strebel': [2167, 3473], '2280-2288Crossref': [2175], 'Vif': [2179], 'links': [2180], 'APOBEC3G,': [2187], 'facilitating': [2188], 'degradation.': [2190], 'Vif,': [2195], 'APOBEC3G': [2196], 'incorporates': [2197], 'catalyzes': [2202], 'lethal': [2203], 'point': [2204], 'mutations': [2205, 2401], 'genome': [2209], 'during': [2210], '(36Sheehy': [2213], 'A.M.': [2214, 2475, 4277], 'Gaddis': [2215], 'N.C.': [2216], 'Malim': [2217], 'M.H.': [2218], 'Med.': [2220, 2238], '9:': [2222, 2240], '1404-1407Crossref': [2223], '(808)': [2226], '37Marin': [2229], 'Rose': [2231], 'K.M.': [2232], 'Kozak': [2233], 'S.L.': [2234], 'Kabat': [2235], '1398-1403Crossref': [2241], '(683)': [2244], '38Stopak': [2247], 'de': [2249], 'Noronha': [2250], 'Yonemoto': [2252], 'Greene': [2254], 'W.C.': [2255], '12:': [2259], '591-601Abstract': [2260], '(601)': [2268], '39Yu': [2271], 'X.': [2272], 'Yu': [2273, 2283], 'Liu': [2275], 'Luo': [2277], 'Kong': [2279], 'Mao': [2281], 'X.F.': [2284], 'Science.': [2285, 2480, 4282], '302:': [2287], '1056-1060Crossref': [2288], '(999)': [2291], 'work': [2296], 'identifies': [2297], 'third': [2299], 'example': [2300, 2373], 'manipulation': [2302], 'protein.': [2310], 'lines': [2313, 2828, 2843, 2885, 2989, 3789, 3964], 'markedly': [2323, 3815], 'reduced': [2324], 'FIV': [2331, 2677, 2699, 2751, 3637, 3765, 4007, 4121], 'expression': [2333, 2412, 2505, 2666, 3590, 3667, 4123], 'despite': [2334, 3586], 'levels.': [2337], 'Further': [2338], 'study': [2339], 'protect': [2345], 'INs': [2347, 4008], 'degradation,': [2350], 'process': [2352], 'not': [2361, 3791, 3862, 4003], 'residence': [2363], 'provides': [2371], 'manipulates': [2379], 'inhibitory': [2384], 'rather': [2385], 'stimulatory': [2388], 'fashion.': [2389], 'Plasmids—pLEDGF/p75siMut': [2391], 'expresses': [2392, 3714], 'cDNA': [2397, 3546], 'contains': [2398], 'seven': [2399], 'synonymous': [2400], '(shRNA)': [2407], 'site': [2409, 2815], 'permit': [2411], 'endogenous': [2419, 3602], 'plasmid': [2446], 'then': [2448, 2851, 3264, 3352, 3387], 'generate': [2451], 'mutants': [2452], 'lacking': [2453], 'signal': [2457], '(pLEDGF/p75siMut.NLS–)': [2458], '340–417': [2462], '(pLEDGF/p75siMut.Δ340–417)': [2463], 'overlap': [2465], 'extension': [2466], 'PCR.': [2467], '2M.': [2468], 'Vanegas,': [2469], 'manuscript': [2470], 'preparation.': [2472], 'pUbiquitin-HA': [2473, 3170], '(41Musti': [2474, 4276], 'Treier': [2476, 4278], 'Bohmann': [2478, 2494, 4280], '400-402Crossref': [2483, 4285], '(408)': [2486, 4288], 'gift': [2491], '(University': [2495], 'Rochester': [2497], 'Medical': [2498], 'Center).': [2499], 'Wild': [2500], 'plasmids': [2506, 2702, 2809], 'kindly': [2539], '(Rega': [2544], 'Institute,': [2545], 'Leuven).': [2546], 'Culture,': [2548], 'Transfections,': [2549], 'Generation,': [2550], 'Drug': [2552], 'Treatment': [2553], 'LH,': [2555], 'SH,': [2556, 2845, 3049], 'LF,': [2557, 2846, 3050], 'SF': [2559, 3051, 3749, 3772, 3832, 3918, 4095], 'Lines': [2561, 3578], 'Clones—si1340': [2563], '(abbreviated': [2565, 2601], '"L"': [2567], 'cells)': [2568, 2604, 3040, 3052], 'stably': [2569, 2606, 2661, 3624, 4298], 'express': [2570, 2607, 3625, 4299, 4364], 'highly': [2572], 'effective': [2573], 'anti-LEDGF/p75': [2574, 3126, 3320], 'shRNA': [2575, 2610, 3717], 'siScram': [2600], '"S"': [2603], 'control': [2609, 3517, 3711], '(the': [2611], 'Ambion': [2612], '"scramble"': [2613], 'small': [2614], 'interfering': [2615], 'RNA);': [2616], 'each': [2617, 2709], 'derived': [2619, 2685, 2830, 2883, 3656, 3708], '293T': [2621], 'use': [2624], 'previous': [2626], 'studies': [2629], 'L': [2654, 2687, 3672, 3848, 4113, 4151, 4162, 4426], 'plasmids,': [2667], 'generating': [2668, 3699, 3746], 'LH': [2670, 3700, 3752, 3803, 3909, 3932, 3992, 4087, 4294, 4353], 'SH': [2672, 3747, 3770, 3827, 3916, 3934, 3994, 4093, 4292, 4355], 'lines,': [2674, 2679], 'respectively.': [2675, 2692, 3704, 3751], 'Analogous': [2676], 'IN-expressing': [2678], 'LF': [2680, 3422, 3702, 3754, 3808, 3911, 4089], 'SF,': [2682], 'For': [2693, 2999], 'expression,': [2701], 'monocistronic': [2704, 3627, 3977], 'used,': [2708], 'containing': [2710, 3245, 3258], 'open': [2713], 'reading': [2714], 'frame': [2715], 'internal': [2718], 'ribosome': [2719, 2806, 3643], 'entry': [2720, 2807, 3644], 'site-linked': [2721], 'selectable': [2722], 'marker': [2723], 'gene': [2724, 2738, 3634, 3648], '(puromycin': [2725], 'resistance,': [2726], 'pac)': [2727], 'immediately': [2728], 'downstream.': [2729], 'promoter': [2731], 'cytomegalovirus': [2735], 'immediate': [2736], 'promoter,': [2739], 'located': [2740], 'upstream': [2741], 'cDNA.': [2745], 'cDNAs': [2753], 'C-terminally': [2755], 'Myc': [2756], 'epitope-tagged,': [2757], 'no': [2765], 'effect': [2766, 4218], 'Prior': [2801], 'transfection,': [2803], 'IN-internal': [2805], 'site-pac': [2808], 'linearized': [2811], 'restriction': [2814], 'prokaryotic': [2818], 'backbone.': [2819], 'Selection': [2820], 'maintenance': [2822], 'puromycin': [2825, 3047, 3646, 3974, 3983], '3': [2826, 3045, 3972], 'μg/ml;': [2827], 'least': [2833], '1000': [2834], 'separate': [2835], 'colonies.': [2837], 'From': [2838], 'polyclonal': [2841, 3307, 3786], 'founder': [2842, 3787], '(LH,': [2844, 3048], 'SF),': [2847], 'single-cell': [2848, 3798], 'limiting': [2854], 'dilution,': [2855], 'picked': [2856], 'randomly,': [2857], 'assigned': [2859], 'sequential': [2860], 'numbers': [2861], '(e.g.': [2862], 'LH1,': [2863], 'LH2,': [2864], 'LH3);': [2865], '96-well': [2868], 'plates': [2869], 'having': [2870], 'fewer': [2871], '15': [2873], 'positive': [2874], 'wells': [2875], 'chosen': [2877], 'assure': [2879], 'clonality.': [2880], 'Transfections': [2881], 'performed': [2887, 3294], 'calcium': [2890], 'phosphate': [2891], 'coprecipitation': [2892], 'method': [2893], 'total': [2896, 3490, 3510, 3545], '2': [2898, 2937, 3358], 'μg': [2899, 2910], 'DNA': [2901, 2912, 3411], 'per': [2902, 2913], 'well': [2903], 'six-well': [2906], 'plate': [2907], 'chamber': [2914, 2921, 3327], 'two-chamber': [2917], 'LabTek': [2918, 3325], 'II': [2919, 3326], 'glass': [2920], 'slide': [2922], '(Nalge': [2923, 3329], 'Nunc,': [2924], 'Naperville,': [2925, 3331], 'IL).': [2926], 'Briefly,': [2927], '24': [2931, 3012, 4302], 'h': [2932, 2980, 2994, 3013, 3232, 4303], 'after': [2933, 2981, 3014, 4243, 4304], 'being': [2934], 'plated': [2935], 'ml': [2938, 2948], 'medium': [2940, 2950, 3023], '0.45': [2942], '×': [2943, 2953], '106': [2944, 2954], 'cells/well': [2945], '0.8': [2952], 'cells/chamber.': [2955], 'After': [2956, 3147], '14–16': [2957], 'h,': [2958, 3010, 4313], 'transfection': [2960, 2983, 3860, 4305], 'mix': [2961, 2984], 'replaced': [2963], 'fresh': [2965], 'culture': [2966], 'medium.': [2967], 'Cells': [2968, 3016, 3322, 3442, 4041], 'harvested': [2970], 'indirect': [2974], 'immunofluorescence': [2975, 3288, 4431], 'Western': [2977, 4326], 'blotting': [2978, 4327], '40–48': [2979], 'added.': [2986], 'Stable': [2987, 3589], 'incubated': [2991, 3107, 3151, 3195, 3388], '18': [2993, 3009, 4312], 'MG132': [2996, 3246, 4048, 4074, 4131, 4310], '(50': [2997], 'μm).': [2998], 'drug': [3004, 4001], 'added': [3007, 3054], 'starting': [3011], 'transfection.': [3015], 'grown': [3018, 3323], "Dulbecco's": [3020], "Eagle's": [3022], '(Invitrogen)': [3024], 'supplemented': [3025, 3178], '10%': [3027, 3371], 'fetal': [3028, 3372], 'calf': [3029, 3373], 'serum,': [3030], 'penicillin,': [3031], 'streptomycin;': [3033], '200': [3034, 3189], 'μg/ml': [3035, 3046, 3428, 3973], 'hygromycin': [3036, 3043], '(L': [3037], 'combined': [3042], 'indicated.': [3056], 'Immunoblotting—Cells': [3057], 'lysed': [3059, 3172, 3444], 'radioimmune': [3061, 3174, 3446], 'precipitation': [3062, 3175, 3447], 'assay': [3063, 3176, 3448], 'buffer': [3064, 3177, 3244, 3257, 3449], '(150': [3065], 'mm': [3066, 3077, 3377], 'NaCl,': [3067], '0.5%': [3068], 'deoxycholate,': [3069], '0.1%': [3070], 'SDS,': [3071], '1%': [3072], 'Nonidet': [3073], 'P-40,': [3074], '150': [3076], 'Tris-HCl,': [3078], 'pH': [3079], '8.0)': [3080], 'plus': [3081, 3143, 3218], 'protease': [3082, 3187], 'inhibitors': [3083], '(Complete-mini,': [3084], 'Roche': [3085, 3282], 'Applied': [3086, 3209, 3283], 'Science).': [3087, 3284], '(30': [3089], 'μg/lane)': [3090], 'resolved': [3092], 'SDS-10%': [3094], 'polyacrylamide': [3095], 'gels': [3096], 'transferred': [3098, 3437], 'Immobilon': [3100], 'P': [3101], 'membranes': [3102, 3105, 3149], '(Millipore).': [3103], 'Blocked': [3104], 'overnight': [3108], '4°': [3110, 3234], 'anti-Myc': [3113, 3300, 3308], 'epitope': [3114, 3301], 'antibody': [3116, 3133, 3217, 3273, 3279, 3309, 3401, 3405], '(mAb,': [3117], 'clone': [3118], '9E10,': [3119], 'Covance),': [3120], 'anti-α-tubulin': [3121], 'mAb': [3122, 3127, 3207, 3302], '(clone': [3123, 3280, 3303], 'B-5-1–2,': [3124], 'Sigma),': [3125], '(BD': [3128], 'Biosciences),': [3129], 'rabbit': [3132, 3214, 3270], 'Tris-buffered': [3138], 'saline,': [3139, 3350], '5%': [3140], 'nonfat': [3141], 'milk': [3142], '0.05%': [3144], 'Tween': [3145], '20.': [3146], 'washing,': [3148], 'appropriate': [3154, 3391], 'horseradish': [3155], 'peroxidase-tagged': [3156], 'secondary': [3157], 'antibody.': [3158], 'Bound': [3159], 'antibodies': [3160, 3392], 'detected': [3162, 3318, 3488, 3846, 4148, 4398], 'ECL': [3164], '(Amersham': [3165], 'Biosciences).': [3166], 'Immunoprecipitation—Cells': [3167], 'cotransfected': [3168], '50': [3180], 'μm': [3181], 'MG132,': [3182], '10': [3183, 3342], 'mmN-ethylmaleimide': [3184], '(Sigma)': [3185], 'inhibitors.': [3188], 'μl': [3190, 3198, 3220], 'lysate': [3193], '30': [3197, 3219, 3381, 3431], 'agarose': [3200], 'beads': [3201, 3223, 3237], 'coupled': [3202, 3224], 'rat': [3205, 3277], 'anti-HA': [3206, 3276], '(Roche': [3208], 'Science)': [3210], 'anti-HIV': [3215], 'magnetic': [3222], '(Dynal': [3228], 'Biotech)': [3229], 'washed': [3239, 3347], 'three': [3240], 'times': [3241], 'lysis': [3243], 'N-ethylmaleimide': [3248], 'followed': [3249, 3393, 4324], 'boiling': [3251], '7': [3253], 'min': [3254, 3343, 3359, 3382, 3432], 'Laemmli': [3256], 'β-mercaptoethanol.': [3259], 'immunoprecipitated': [3261, 4319, 4350, 4387], 'evaluated': [3265, 4028, 4050], 'immunoblotting': [3267, 3495, 4052], 'anti-HIV-1': [3271], '3F10,': [3281], 'Confocal': [3285], 'Immunofluorescence': [3286], 'Microscopy—Indirect': [3287], 'detection': [3289], 'Myc-tagged': [3291], 'confocal': [3296], 'fluorescence': [3297], 'microscopy': [3298], '9E10)': [3304], '(Santa': [3310], 'Cruz': [3311], 'Biotechnology)': [3312], 'costained.': [3314], 'Endogenous': [3315], 'mAb.': [3321], 'slides': [3328], 'Nunc': [3330], 'IL)': [3332], 'fixed': [3334], '4%': [3336], 'formaldehyde': [3337], 'phosphate-buffered': [3339, 3349, 3368], 'saline': [3340, 3369], '37°': [3345, 3434], 'C,': [3346], 'permeabilized': [3353], 'ice-cold': [3355], 'methanol': [3356], 'room': [3361, 3384], 'temperature.': [3362], 'Fixed': [3363], 'blocked': [3366], 'serum': [3374], 'ammonium': [3378], 'chloride': [3379], 'temperature': [3385], 'Alexa-488-': [3395], 'Texas': [3397], 'Red-conjugated': [3398], 'goat': [3399, 3403], 'anti-mouse': [3400], 'anti-rabbit': [3404], '(Molecular': [3406, 3416], 'Probes,': [3407], 'Eugene,': [3408], 'OR).': [3409], 'Nuclear': [3410, 4415], 'stained': [3413], '4′,6-diamidino-2-phenylindole': [3415], 'Probes).': [3417], 'Protein': [3418], 'Half-life': [3419, 4413], 'Determination—LH': [3420], 'treated': [3425, 4043, 4308], '5': [3427], 'cycloheximide': [3429], 'ice': [3439], 'until': [3440], 'analysis.': [3441], '(total': [3450], 'fraction),': [3451], 'fractions': [3457, 3493], 'isolated': [3459], 'described': [3461, 3497], '(42Nguyen': [3463], 'K.L.': [3464], 'Llano': [3465], 'Akari': [3467], 'Miyagi': [3469], '319:': [3479], '163-175Crossref': [3480], '(140)': [3483], 'above.': [3498], 'RT-PCR—cDNA': [3499], 'prepared': [3501, 3515], 'random': [3503], 'hexamer': [3504], 'priming,': [3505], '500': [3507], 'ng': [3508], 'template': [3513], 'lines.': [3521], 'Reactions': [3522], 'carried': [3524], 'out': [3525], 'ProStar': [3528], 'Ultra': [3529], 'HF': [3530], 'RT-PCR': [3531], '(Stratagene).': [3533], 'Minus': [3534], 'RT': [3535], 'controls': [3536], 'omitted': [3537], 'transcriptase.': [3541], 'One-seventeenth': [3542], 'PCR': [3551], 'reaction': [3552], 'amplify': [3554], 'full-length': [3555], 'sense': [3560], '5′-ATATGGATCCAATGTTTTTAGATGG-3′': [3561], 'antisense': [3563], '5′-ATATACCGGTGGGTCCTCATCCTGTC-3′': [3564], 'primers.': [3565], 'Glyceraldehyde-3-phosphate': [3566], 'dehydrogenase': [3567], 'primers': [3568], 'loading': [3574], 'control.': [3575], 'Express': [3579], 'Lower': [3580], 'Levels': [3581], 'Lentiviral': [3583], 'Integrase': [3584], 'Equivalent': [3587], 'mRNA—': [3588], 'optimize': [3597], 'assessments': [3598], 'interactions': [3600], 'analyze': [3605], 'levels,': [3609, 4026], 'allow': [3611], 'tracking': [3612], 'cycle.': [3618], 'Puromycin': [3619], 'selection': [3620, 3969, 4117], 'single': [3626], 'mRNAs': [3628, 3978], 'contain': [3630], '(HIV-1': [3635], 'IN)': [3638], 'downstream': [3641], '(internal': [3642], 'site-linked)': [3645], 'resistance': [3647], '(see': [3649], '"Experimental': [3650], 'Procedures").': [3651], 'puromycin-stable': [3653], 'transfectants': [3654], 'line': [3660], 'severely': [3663], 'shRNAs': [3669], '(si1340': [3670], 'Scholar)),': [3697, 3745], 'thus': [3698], 'They': [3705], 'line,': [3712], 'scrambled': [3716], '(siScram': [3718], 'did': [3769, 3826], '(Fig.': [3774, 3800, 3946, 4053, 4097, 4124, 4178, 4224, 4246, 4333, 4372, 4388, 4404], '1A).': [3775, 3801], 'consistently': [3781], '(data': [3790, 3861, 4002], 'shown)': [3792], 'multiple': [3795], 'randomly': [3796], 'selected': [3797], 'All': [3802], '(n': [3804, 3809, 3828, 3833], '=': [3805, 3810, 3829, 3834], '5)': [3806], '6)': [3811], 'had': [3814], 'respective': [3822], '9)': [3830], '11)': [3835], 'clones.': [3837], 'transient': [3859], 'shown).': [3863, 4004], 'Available': [3864], 'data': [3865, 4077, 4249], 'suggest': [3866], 'act': [3874], 'Therefore,': [3895], 'one': [3896], 'explain': [3899], 'compared': [3914], 'production.': [3924], 'However': [3925], 'even': [3936], 'divergent': [3939], '1B),': [3947], 'indicating': [3948], 'post-transcriptional': [3950, 4022], 'mechanism.': [3951], 'consistent': [3958], 'way': [3961], 'derived,': [3966], 'uniform': [3968], 'pressure': [3970], 'encoding': [3979], 'resistance.': [3984], 'Growth': [3985], 'rates': [3986], 'Undergo': [4009], 'Proteasomal': [4010], 'Degradation': [4011], 'Are': [4013], 'Ubiquitinated—Because': [4014], 'important': [4021], 'inhibitor': [4047], '2,': [4054, 4098, 4125, 4179], 'compare': [4055, 4062, 4180], 'lanes': [4056, 4059, 4063, 4066, 4099, 4126, 4129, 4181, 4184], '1–4': [4057, 4182], '5–8': [4060], '9–11': [4064], '12–14).': [4067], 'Results': [4068], 'obtained': [4069], 'Fig.': [4079], '1A,': [4080], '1–4,': [4100], '9,': [4101], '10).': [4103], 'Note': [4104], 'remained': [4110], 'stringent': [4111], '1–8': [4127], '9–14).': [4130], 'caused': [4132], 'marked': [4134], 'increase': [4135, 4145], 'could': [4146], 'clones,': [4154, 4163], 'magnitude': [4157], 'larger': [4160, 4223], 'where': [4164], 'WT': [4171, 4458], 'undetectable': [4173], 'barely': [4175], 'detectable': [4176], '5–8).': [4185], 'c-Myc,': [4186], '(43Gregory': [4193], 'Hann': [4195], 'S.R.': [4196], '20:': [4201], '2423-2435Crossref': [4202], '(365)': [4205], 'Scholar),': [4207], 'MG132-treated': [4214], 'although': [4216, 4467], '2).': [4225, 4247], 'such': [4233], 'tubulin': [4235], 'and,': [4236], 'importantly,': [4238], 'decreased': [4241], 'slightly': [4242], 'These': [4248], 'indicate': [4250], 'regulates': [4263], 'process.': [4265], 'targeting': [4267], 'results': [4268], 'polyubiquitination.': [4270], 'HA-tagged': [4274], 'lysates': [4316], 'reciprocally': [4318], 'HA-ubiquitin': [4321], 'HA-ubiquitin,': [4331], 'respectively': [4332], '3,': [4334], 'B).': [4337], 'Higher': [4338], 'molecular': [4339], 'mass': [4340], 'forms': [4342], '(>37.1-kDa': [4343], 'marker)': [4344], 'specifically': [4349, 4397], 'approaches.': [4360], 'SH1': [4362], 'higher': [4365], 'LH4': [4370, 4380], '1A),': [4373], 'ubiquitin-modified': [4383], 'directly': [4386], '3A).': [4389], 'When': [4390], 'immunoprecipitated,': [4393], 'types': [4401], '3B).': [4405], 'Cytoplasmic': [4406], 'Has': [4409], 'Shorter': [4411], 'Cellular': [4412], 'IN—HIV-1': [4417], 'analyzed': [4429], 'localizes': [4463], 'overwhelmingly': [4464], 'nuclei,': [4466], 'some': [4468], 'immunoprecipi': [4472]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2055697700', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-07T23:54:31.812109', 'created_date': '2016-06-24'}
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