Title: Activation of adenylate cyclase by Guanosine 5′ α, β methylene triphosphate
Abstract: Guanosine 5′ α, β methylene triphosphate activates adenylate cyclase of pigeon erythrocyte ghosts. Activation is inhibited by GTP, persists after free guanosine 5′ α, β methylene triphosphate is removed, and proceeds more rapidly in the presence of isoproterenol. Guanosine 5′ methylene diphosphate neither activates adenylate cyclase nor inhibits activation of adenylate cyclase by guanosine 5′ α, β methylene triphosphate. These results exclude pyrophosphorylation as a mechanism by which GTP normally activates adenylate cyclase.
Publication Year: 1977
Publication Date: 1977-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 2
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