Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2055429090', 'doi': 'https://doi.org/10.1002/ddr.430340205', 'title': 'Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase', 'display_name': 'Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase', 'publication_year': 1995, 'publication_date': '1995-02-01', 'ids': {'openalex': 'https://openalex.org/W2055429090', 'doi': 'https://doi.org/10.1002/ddr.430340205', 'mag': '2055429090'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ddr.430340205', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S26306840', 'display_name': 'Drug Development Research', 'issn_l': '0272-4391', 'issn': ['0272-4391', '1098-2299'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055686899', 'display_name': 'Veeraswamy Manne', 'orcid': 'https://orcid.org/0000-0002-1179-5529'}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Veeraswamy Manne', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053151692', 'display_name': 'Carolyn S. Ricca', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Carolyn S. Ricca', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003811581', 'display_name': 'Johnni Gullo Brown', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Johnni Gullo Brown', 'raw_affiliation_strings': ['Department of Molecular Biology, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072193915', 'display_name': 'A V Tuomari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Anne V. Tuomari', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080019069', 'display_name': 'Ning Yan', 'orcid': 'https://orcid.org/0000-0002-3302-4733'}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ning Yan', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013796535', 'display_name': 'Dinesh V. Patel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dinesh Patel', 'raw_affiliation_strings': ['Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025684816', 'display_name': 'Robert J. Schmidt', 'orcid': 'https://orcid.org/0000-0003-1552-781X'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Schmidt', 'raw_affiliation_strings': ['Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022430976', 'display_name': 'Mark Lynch', 'orcid': 'https://orcid.org/0000-0002-8476-4854'}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Mark J. Lynch', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033719788', 'display_name': 'Carl P. Ciosek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Carl P. Ciosek', 'raw_affiliation_strings': ['Department of Metabolic Diseases, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Diseases, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088565265', 'display_name': 'Joan M. Carboni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Joan M. Carboni', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040854848', 'display_name': 'Simon P. Robinson', 'orcid': 'https://orcid.org/0000-0003-4812-6094'}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Simon Robinson', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013063171', 'display_name': 'Eric M. Gordon', 'orcid': 'https://orcid.org/0000-0002-8692-9456'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric M. Gordon', 'raw_affiliation_strings': ['Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056668478', 'display_name': 'Mariano Barbacid', 'orcid': 'https://orcid.org/0000-0002-1480-2624'}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Mariano Barbacid', 'raw_affiliation_strings': ['Department of Molecular Biology, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032398736', 'display_name': 'Bernd R. Seizinger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157075465', 'display_name': 'Bristol-Myers Squibb (Germany)', 'ror': 'https://ror.org/032hfv632', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I157075465', 'https://openalex.org/I4210091812']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernd R. Seizinger', 'raw_affiliation_strings': ['Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Oncology Drug Discovery, Bristol‐Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I157075465']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028076816', 'display_name': 'Scott A. Biller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott A. Biller', 'raw_affiliation_strings': ['Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey'], 'affiliations': [{'raw_affiliation_string': 'Division of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey', 'institution_ids': ['https://openalex.org/I4210091812']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.073, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 69, 'citation_normalized_percentile': {'value': 0.806154, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '34', 'issue': '2', 'first_page': '121', 'last_page': '137'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2 Signaling in Breast Cancer Treatment', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/farnesyltransferase-inhibitor', 'display_name': 'Farnesyltransferase inhibitor', 'score': 0.8190713}, {'id': 'https://openalex.org/keywords/farnesyl-pyrophosphate', 'display_name': 'Farnesyl pyrophosphate', 'score': 0.79930437}, {'id': 'https://openalex.org/keywords/farnesyl-diphosphate-farnesyltransferase', 'display_name': 'Farnesyl-diphosphate farnesyltransferase', 'score': 0.6638435}, {'id': 'https://openalex.org/keywords/ras-signaling', 'display_name': 'Ras Signaling', 'score': 0.546326}, {'id': 'https://openalex.org/keywords/geranylgeranylation', 'display_name': 'Geranylgeranylation', 'score': 0.4286101}], 'concepts': [{'id': 'https://openalex.org/C2778396349', 'wikidata': 'https://www.wikidata.org/wiki/Q410994', 'display_name': 'Farnesyltransferase', 'level': 4, 'score': 0.9915631}, {'id': 'https://openalex.org/C57790582', 'wikidata': 'https://www.wikidata.org/wiki/Q901141', 'display_name': 'Prenylation', 'level': 3, 'score': 0.94615394}, {'id': 'https://openalex.org/C2777827897', 'wikidata': 'https://www.wikidata.org/wiki/Q5436005', 'display_name': 'Farnesyltransferase inhibitor', 'level': 5, 'score': 0.8190713}, {'id': 'https://openalex.org/C2776990775', 'wikidata': 'https://www.wikidata.org/wiki/Q2699676', 'display_name': 'Farnesyl pyrophosphate', 'level': 4, 'score': 0.79930437}, {'id': 'https://openalex.org/C2779716203', 'wikidata': 'https://www.wikidata.org/wiki/Q410600', 'display_name': 'Farnesyl-diphosphate farnesyltransferase', 'level': 5, 'score': 0.6638435}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.54876065}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5099083}, {'id': 'https://openalex.org/C23167141', 'wikidata': 'https://www.wikidata.org/wiki/Q14912965', 'display_name': 'Geranylgeranylation', 'level': 4, 'score': 0.4286101}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38247252}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.34973377}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32174549}, {'id': 'https://openalex.org/C112243037', 'wikidata': 'https://www.wikidata.org/wiki/Q22327117', 'display_name': 'ATP synthase', 'level': 3, 'score': 0.14781147}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ddr.430340205', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S26306840', 'display_name': 'Drug Development Research', 'issn_l': '0272-4391', 'issn': ['0272-4391', '1098-2299'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.72, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 84, 'referenced_works': ['https://openalex.org/W1484076261', 'https://openalex.org/W1517380923', 'https://openalex.org/W1521017148', 'https://openalex.org/W1522954144', 'https://openalex.org/W1522954291', 'https://openalex.org/W1544277307', 'https://openalex.org/W1547357282', 'https://openalex.org/W1557478309', 'https://openalex.org/W1562589309', 'https://openalex.org/W1563194997', 'https://openalex.org/W1569256603', 'https://openalex.org/W1571720205', 'https://openalex.org/W1572144604', 'https://openalex.org/W1580812515', 'https://openalex.org/W158810188', 'https://openalex.org/W1591084420', 'https://openalex.org/W1602384986', 'https://openalex.org/W1639281802', 'https://openalex.org/W1784068511', 'https://openalex.org/W1799140375', 'https://openalex.org/W1970030465', 'https://openalex.org/W1972240604', 'https://openalex.org/W1975993749', 'https://openalex.org/W1977152201', 'https://openalex.org/W1980137406', 'https://openalex.org/W1985666310', 'https://openalex.org/W1987757198', 'https://openalex.org/W1987781517', 'https://openalex.org/W1989467733', 'https://openalex.org/W1991350838', 'https://openalex.org/W1991406959', 'https://openalex.org/W1992580546', 'https://openalex.org/W1995010544', 'https://openalex.org/W1998114485', 'https://openalex.org/W1998466191', 'https://openalex.org/W1999973609', 'https://openalex.org/W2003267467', 'https://openalex.org/W2004147779', 'https://openalex.org/W2010207338', 'https://openalex.org/W2010955929', 'https://openalex.org/W2018441710', 'https://openalex.org/W2036082581', 'https://openalex.org/W2037480365', 'https://openalex.org/W2039872903', 'https://openalex.org/W2040315421', 'https://openalex.org/W2041316505', 'https://openalex.org/W2042398627', 'https://openalex.org/W2044713093', 'https://openalex.org/W2046579661', 'https://openalex.org/W2053799953', 'https://openalex.org/W2055097128', 'https://openalex.org/W2059800438', 'https://openalex.org/W2062427243', 'https://openalex.org/W2065892708', 'https://openalex.org/W2066696278', 'https://openalex.org/W2068032848', 'https://openalex.org/W2068669272', 'https://openalex.org/W2070023258', 'https://openalex.org/W2070090561', 'https://openalex.org/W207418012', 'https://openalex.org/W2085140159', 'https://openalex.org/W2089399167', 'https://openalex.org/W2090702802', 'https://openalex.org/W2091679884', 'https://openalex.org/W2095365445', 'https://openalex.org/W2098806204', 'https://openalex.org/W2102901045', 'https://openalex.org/W2120256795', 'https://openalex.org/W2133362776', 'https://openalex.org/W2144774847', 'https://openalex.org/W2149344188', 'https://openalex.org/W2158407439', 'https://openalex.org/W2159594827', 'https://openalex.org/W2162658068', 'https://openalex.org/W2167885774', 'https://openalex.org/W2168267287', 'https://openalex.org/W2417007830', 'https://openalex.org/W2497402342', 'https://openalex.org/W2619559059', 'https://openalex.org/W3118895760', 'https://openalex.org/W4232777855', 'https://openalex.org/W4236495729', 'https://openalex.org/W424947976', 'https://openalex.org/W4388277923'], 'related_works': ['https://openalex.org/W2339901706', 'https://openalex.org/W2302931308', 'https://openalex.org/W2162998993', 'https://openalex.org/W2150968221', 'https://openalex.org/W2055429090', 'https://openalex.org/W2055097128', 'https://openalex.org/W2022568662', 'https://openalex.org/W1998216249', 'https://openalex.org/W1984485872', 'https://openalex.org/W1972568498'], 'abstract_inverted_index': {'Abstract': [0], 'Protein': [1], 'prenylation': [2, 39], 'is': [3, 18, 162], 'increasingly': [4], 'recognized': [5], 'as': [6, 79, 147], 'an': [7, 167], 'important': [8], 'mechanism': [9], 'by': [10, 149, 174], 'which': [11], 'functional': [12], 'association': [13], 'of': [14, 23, 36, 55, 69, 76, 98, 110, 122, 124, 131, 151, 166], 'proteins': [15, 31, 44, 156], 'to': [16, 74, 83, 86, 116, 170], 'membranes': [17], 'mediated.': [19], 'Ras': [20], 'proteins,': [21], 'regulators': [22], 'cell': [24], 'proliferation': [25], 'and': [26, 90, 107, 140], 'differentiation,': [27], 'are': [28, 45, 105], 'among': [29], 'the': [30, 37, 72, 96, 138, 163], 'that': [32, 59, 104], 'undergo': [33], 'farnesylation,': [34], 'one': [35, 123], 'two': [38, 99], 'modifications': [40], 'known.': [41], 'Since': [42], 'ras': [43, 62, 88, 128, 145, 155, 176], 'activated': [46], 'into': [47, 154], 'hyperactive': [48], 'oncogenic': [49], 'versions': [50], 'in': [51, 157, 178], 'a': [52, 119], 'wide': [53], 'variety': [54], 'human': [56], 'cancers,': [57], 'agents': [58, 81], 'down': [60], 'modulate': [61], 'activity': [63, 173], 'could': [64], 'be': [65, 75], 'antineoplastic.': [66], 'Therefore,': [67], 'inhibitors': [68, 109, 126], 'farnesyltransferase': [70], 'have': [71], 'potential': [73], 'therapeutic': [77], 'value': [78], 'anticancer': [80], 'due': [82], 'their': [84], 'ability': [85], 'block': [87], 'processing': [89, 177], 'hence': [91], 'its': [92, 141], 'function.': [93], 'We': [94], 'describe': [95], 'identification': [97], 'farnesyl': [100], 'pyrophosphate': [101], '(FPP)': [102], 'analogs': [103], 'potent': [106], 'selective': [108], 'farnesyltransferase.': [111], 'While': [112], 'showing': [113], 'no': [114], 'toxicity': [115], 'untransformed': [117], 'cells,': [118], 'pivaloyloxymethyl': [120], 'ester': [121, 139], 'these': [125], 'blocked': [127], 'mediated': [129], 'transformation': [130], 'NIH': [132], '3T3': [133], 'cells.': [134, 159, 180], 'In': [135], 'addition,': [136], 'both': [137], 'parent': [142], 'acid': [143], 'inhibited': [144], 'farnesylation': [146], 'measured': [148], 'incorporation': [150], 'labeled': [152], 'mevalonate': [153], 'whole': [158, 179], 'Thus,': [160], 'this': [161], 'first': [164], 'report': [165], 'FPP': [168], 'analog': [169], 'show': [171], 'biological': [172], 'inhibiting': [175], '©': [181], '1995': [182], 'Wiley‐Liss,': [183], 'Inc.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2055429090', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-15T01:46:44.164956', 'created_date': '2016-06-24'}