Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2055422733', 'doi': 'https://doi.org/10.1111/j.1538-7836.2009.03620.x', 'title': 'Multi‐step binding of ADAMTS‐13 to von Willebrand factor', 'display_name': 'Multi‐step binding of ADAMTS‐13 to von Willebrand factor', 'publication_year': 2009, 'publication_date': '2009-12-01', 'ids': {'openalex': 'https://openalex.org/W2055422733', 'doi': 'https://doi.org/10.1111/j.1538-7836.2009.03620.x', 'mag': '2055422733', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19765212', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3863616'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1538-7836.2009.03620.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S164469042', 'display_name': 'Journal of Thrombosis and Haemostasis', 'issn_l': '1538-7836', 'issn': ['1538-7836', '1538-7933'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3863616?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086939300', 'display_name': 'Hendrik B. Feys', 'orcid': 'https://orcid.org/0000-0003-0052-8852'}, 'institutions': [{'id': 'https://openalex.org/I4210101017', 'display_name': 'Research Institute for Chromatography', 'ror': 'https://ror.org/00yhmjd28', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101017']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}, {'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['BE', 'US'], 'is_corresponding': False, 'raw_author_name': 'H.B. FEYS', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA', 'Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium', 'institution_ids': ['https://openalex.org/I4210101017', 'https://openalex.org/I99464096']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033221167', 'display_name': 'Patricia J. Anderson', 'orcid': 'https://orcid.org/0009-0009-8374-274X'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P.J. ANDERSON', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010065750', 'display_name': 'Karen Vanhoorelbeke', 'orcid': 'https://orcid.org/0000-0003-2288-8277'}, 'institutions': [{'id': 'https://openalex.org/I4210101017', 'display_name': 'Research Institute for Chromatography', 'ror': 'https://ror.org/00yhmjd28', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101017']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'K. VANHOORELBEKE', 'raw_affiliation_strings': ['Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium', 'institution_ids': ['https://openalex.org/I4210101017', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086883350', 'display_name': 'Elaine M. Majerus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E.M. MAJERUS', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005704032', 'display_name': 'J. Evan Sadler', 'orcid': 'https://orcid.org/0000-0001-5705-469X'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J.E. SADLER', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Department of Medicine, Washington University, School of Medicine, St Louis, MO, USA', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3750, 'currency': 'USD', 'value_usd': 3750, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.779, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 87, 'citation_normalized_percentile': {'value': 0.922106, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '7', 'issue': '12', 'first_page': '2088', 'last_page': '2095'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10993', 'display_name': 'Role of Complement System in Immune Response', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10993', 'display_name': 'Role of Complement System in Immune Response', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9903, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adamts', 'display_name': 'ADAMTS', 'score': 0.89837456}, {'id': 'https://openalex.org/keywords/adamts13', 'display_name': 'ADAMTS13', 'score': 0.53159}, {'id': 'https://openalex.org/keywords/von-willebrand-disease', 'display_name': 'Von Willebrand disease', 'score': 0.42833826}], 'concepts': [{'id': 'https://openalex.org/C2779394231', 'wikidata': 'https://www.wikidata.org/wiki/Q412310', 'display_name': 'Von Willebrand factor', 'level': 3, 'score': 0.9509525}, {'id': 'https://openalex.org/C2776224515', 'wikidata': 'https://www.wikidata.org/wiki/Q102253084', 'display_name': 'ADAMTS', 'level': 5, 'score': 0.89837456}, {'id': 'https://openalex.org/C167814343', 'wikidata': 'https://www.wikidata.org/wiki/Q419341', 'display_name': 'Thrombospondin', 'level': 4, 'score': 0.7926864}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7495487}, {'id': 'https://openalex.org/C2780921031', 'wikidata': 'https://www.wikidata.org/wiki/Q14873945', 'display_name': 'ADAMTS13', 'level': 4, 'score': 0.6550434}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.50335425}, {'id': 'https://openalex.org/C26828662', 'wikidata': 'https://www.wikidata.org/wiki/Q7202248', 'display_name': 'Platelet membrane glycoprotein', 'level': 3, 'score': 0.4644518}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.43864992}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.43611118}, {'id': 'https://openalex.org/C2778780528', 'wikidata': 'https://www.wikidata.org/wiki/Q709360', 'display_name': 'Von Willebrand disease', 'level': 4, 'score': 0.42833826}, {'id': 'https://openalex.org/C55728118', 'wikidata': 'https://www.wikidata.org/wiki/Q425402', 'display_name': 'Metalloproteinase', 'level': 3, 'score': 0.31963366}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26048315}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.2244128}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.16063845}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.10825908}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.107824564}], 'mesh': [{'descriptor_ui': 'D051722', 'descriptor_name': 'ADAM Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051722', 'descriptor_name': 'ADAM Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051722', 'descriptor_name': 'ADAM Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071120', 'descriptor_name': 'ADAMTS13 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001775', 'descriptor_name': 'Blood Circulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013314', 'descriptor_name': 'Stress, Mechanical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1538-7836.2009.03620.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S164469042', 'display_name': 'Journal of Thrombosis and Haemostasis', 'issn_l': '1538-7836', 'issn': ['1538-7836', '1538-7933'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3863616', 'pdf_url': 'https://europepmc.org/articles/pmc3863616?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863616', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19765212', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3863616', 'pdf_url': 'https://europepmc.org/articles/pmc3863616?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1504674459', 'https://openalex.org/W1964738009', 'https://openalex.org/W1972595265', 'https://openalex.org/W1974758418', 'https://openalex.org/W1977024178', 'https://openalex.org/W1984795026', 'https://openalex.org/W2000111712', 'https://openalex.org/W2010754623', 'https://openalex.org/W2030337128', 'https://openalex.org/W2033568440', 'https://openalex.org/W2035454293', 'https://openalex.org/W2039852043', 'https://openalex.org/W2045969435', 'https://openalex.org/W2049826175', 'https://openalex.org/W2050360519', 'https://openalex.org/W2054326159', 'https://openalex.org/W2069743147', 'https://openalex.org/W2069779742', 'https://openalex.org/W2080297087', 'https://openalex.org/W2081075409', 'https://openalex.org/W2081382831', 'https://openalex.org/W2095299313', 'https://openalex.org/W2100189307', 'https://openalex.org/W2105300860', 'https://openalex.org/W2114480478', 'https://openalex.org/W2121859722', 'https://openalex.org/W2125023500', 'https://openalex.org/W2128727430', 'https://openalex.org/W2136259911', 'https://openalex.org/W2137827663', 'https://openalex.org/W2151187602', 'https://openalex.org/W2270564137', 'https://openalex.org/W2764868574', 'https://openalex.org/W276645119', 'https://openalex.org/W59737231'], 'related_works': ['https://openalex.org/W3186690237', 'https://openalex.org/W3144499377', 'https://openalex.org/W3030496443', 'https://openalex.org/W2989609610', 'https://openalex.org/W2941734048', 'https://openalex.org/W2463644649', 'https://openalex.org/W2392809711', 'https://openalex.org/W2063411708', 'https://openalex.org/W2026002230', 'https://openalex.org/W1971720270'], 'abstract_inverted_index': {'ADAMTS-13': [0, 37, 50, 85, 136, 152, 167], 'proteolytic': [1], 'activity': [2], 'is': [3, 30, 145, 201], 'controlled': [4], 'by': [5, 77, 203], 'the': [6, 18, 40, 151], 'conformation': [7], 'of': [8, 21, 58, 63, 92, 105, 131, 171], 'its': [9], 'substrate,': [10], 'von': [11], 'Willebrand': [12], 'factor': [13], '(VWF),': [14], 'and': [15, 55, 69, 80, 110, 123, 185], 'changes': [16], 'in': [17, 36, 51, 161], 'secondary': [19], 'structure': [20], 'VWF': [22, 52, 60, 90, 111, 117, 144, 169, 184, 199], 'are': [23, 53], 'essential': [24], 'for': [25, 49], 'efficient': [26], 'cleavage.': [27], 'Substrate': [28], 'recognition': [29], 'mediated': [31, 146], 'through': [32, 147], 'several': [33], 'non-catalytic': [34], 'domains': [35, 148], 'distant': [38], 'from': [39], 'active': [41], 'site.We': [42], 'hypothesized': [43], 'that': [44, 84, 140, 200], 'not': [45, 125], 'all': [46], 'binding': [47, 57, 107, 141], 'sites': [48], 'cryptic': [54], 'analyzed': [56], 'native': [59, 88, 116, 143], 'to': [61, 87, 115, 142, 150, 168, 182], 'ADAMTS-13.Immunoprecipiation': [62], 'VWF-ADAMTS-13': [64], 'complexes': [65], 'using': [66], 'anti-VWF': [67], 'antibodies': [68], 'magnetic': [70], 'beads': [71], 'was': [72, 75, 112, 118], 'used.': [73], 'Binding': [74, 114], 'assessed': [76], 'Western': [78], 'blotting': [79], 'immunosorbent': [81], 'assays.Co-immunoprecipitation': [82], 'demonstrated': [83], 'binds': [86, 181], 'multimeric': [89], '(K(d)': [91], '79': [93], '+/-': [94, 173, 176], '11': [95], 'nmol': [96], 'L(-1))': [97], 'with': [98, 127, 135, 165], 'no': [99], 'measurable': [100], 'proteolysis.': [101], 'Upon': [102], 'shear-induced': [103], 'unfolding': [104], 'VWF,': [106], 'increased': [108], '3-fold': [109], 'cleaved.': [113], 'saturable,': [119], 'time': [120], 'dependent,': [121], 'reversible': [122], 'did': [124], 'vary': [126], 'ionic': [128], 'strength': [129], '(I': [130], '50-200).': [132], 'Moreover,': [133], 'results': [134], 'deletion': [137], 'mutants': [138], 'indicated': [139], 'distal': [149], 'spacer,': [153], 'probably': [154], 'thrombospondin-1': [155], 'repeats.': [156], 'Interestingly,': [157], 'this': [158], 'interaction': [159], 'occurs': [160], 'normal': [162], 'human': [163], 'plasma': [164], 'an': [166], 'stoichiometry': [170], '0.0040': [172], '0.0004': [174], '(mean': [175], 'SEM,': [177], 'n': [178], '=': [179], '10).ADAMTS-13': [180], 'circulating': [183], 'may': [186], 'therefore': [187], 'be': [188], 'incorporated': [189], 'into': [190], 'a': [191], 'platelet-rich': [192], 'thrombus,': [193], 'where': [194], 'it': [195], 'can': [196], 'immediately': [197], 'cleave': [198], 'unfolded': [202], 'fluid': [204], 'shear': [205], 'stress.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2055422733', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-08-22T09:28:40.068731', 'created_date': '2016-06-24'}