Title: AN fMRI EXAMINATION OF VISUAL INTEGRATION IN SCHIZOPHRENIA
Abstract: Journal of Integrative NeuroscienceVol. 08, No. 02, pp. 175-202 (2009) Research ReportsNo AccessAN fMRI EXAMINATION OF VISUAL INTEGRATION IN SCHIZOPHRENIASTEVEN M. SILVERSTEIN, SARAH BERTEN, BRIAN ESSEX, ILONA KOVÁCS, TERESA SUSMARAS, and DEBORAH M. LITTLESTEVEN M. SILVERSTEINUniversity of Medicine and Dentistry of New Jersey — University Behavioral HealthCare and Department of Psychiatry, Robert Wood Johnson Medical School, USADepartment of Psychiatry, University of Illinois at Chicago, USACorresponding author., SARAH BERTENUniversity of Medicine and Dentistry of New Jersey — University Behavioral HealthCare and Department of Psychiatry, Robert Wood Johnson Medical School, USADepartment of Psychiatry, University of Illinois at Chicago, USA, BRIAN ESSEXDepartment of Psychiatry, University of Illinois at Chicago, USA, ILONA KOVÁCSDepartment of Cognitive Science, Budapest University of Technology and Economics, Hungary, TERESA SUSMARASDepartments of Neurology and Rehabilitation, Anatomy and Cell Biology, Ophthalmology and Visual Sciences, and Psychology, University of Illinois at Chicago, USA, and DEBORAH M. LITTLEDepartment of Psychiatry, University of Illinois at Chicago, USADepartments of Neurology and Rehabilitation, Anatomy and Cell Biology, Ophthalmology and Visual Sciences, and Psychology, University of Illinois at Chicago, USAhttps://doi.org/10.1142/S0219635209002113Cited by:76 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractBehavioral and electrophysiological studies of schizophrenia have consistently demonstrated impairments in the integration of visual features into unified perceptual representations. Specific brain regions involved in this dysfunction, however, remain to be clarified. This study used functional Magnetic Resonance Imaging (fMRI) to examine the relative involvement of visual cortex areas (involved in form perception) and parietal and frontal regions (involved in attention), in the visual integration impairment in schizophrenia. Fourteen patients with schizophrenia and 14 healthy controls were compared on behavioral performance and data acquired via fMRI while completing a contour integration task that had previously been used to identify a visual integration deficit in schizophrenia. The schizophrenia patients demonstrated poorer visual integration than controls. Analyses of peak signal change indicated that while the groups were equivalent in area V1, the schizophrenia group demonstrated reduced signal in areas V2–V4, which are the earliest regions sensitive to global configurations of stimuli. Moreover, whereas the control group demonstrated greater recruitment of prefrontal and parietal areas during perception of integrated forms compared to random stimuli, the schizophrenia group demonstrated greater recruitment of frontal regions during perception of random stimuli. The two groups differed on brain regions involved in form perception even when they were matched on accuracy levels. The visual integration disturbance in schizophrenia involves both deficient basic visual processes (beginning as early as occipital region V2), as well as reduced feedback from visual attention regions that normally serves to amplify relevant visual representations relative to irrelevant information.Keywords:SchizophreniafMRIperceptioncognitionvisionoccipital lobe References C. F. Altmann, H. H. Bulthoff and Z. Kourtzi, Curr. Bio. 13, 342 (2003), DOI: 10.1016/S0960-9822(03)00052-6. Crossref, Medline, ISI, Google ScholarC. F. Altmann, A. Deubelius and Z. Kourtzi, J. Cogn. Neurosci. 16, 794 (2004), DOI: 10.1162/089892904970825. Crossref, Medline, ISI, Google ScholarP. D. Butler, S. M. Silverstein and S. Dakin, Biol. Psychiatry 64, 40 (2008), DOI: 10.1016/j.biopsych.2008.03.023. Crossref, Medline, ISI, Google ScholarV. Carr and J. Wale, Aust. N. Z. J. Psychiatry 20, 136 (1986), DOI: 10.3109/00048678609161327. Crossref, Medline, ISI, Google ScholarC. S. Carter and D. M. Barch, Schizophr. 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Nuechterlein et al.1 Jul 2010 | Biological Psychiatry, Vol. 68, No. 1Increased fusiform area activation in schizophrenia during processing of spatial frequency-degraded faces, as revealed by fMRIS. M. Silverstein, S. D. All, R. Kasi, S. Berten and B. Essex et al.9 November 2009 | Psychological Medicine, Vol. 40, No. 7Abstracts — Tutorials1 May 2010 | Learning & Perception, Vol. 2, No. Supplement 1Der Beitrag der Neuropsychologie für die PsychiatrieKarin Münzel and Josef Zihl1 Jan 2010Perceptual organization in schizophrenia: Plasticity and state-related changeSteven M. Silverstein and Brian P. Keane1 Dec 2009 | Learning & Perception, Vol. 1, No. 2 Recommended Vol. 08, No. 02 Metrics History Received 23 February 2009 Accepted 2 April 2009 KeywordsSchizophreniafMRIperceptioncognitionvisionoccipital lobePDF download
Publication Year: 2009
Publication Date: 2009-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 130
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