Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2054894950', 'doi': 'https://doi.org/10.1016/j.imlet.2015.03.010', 'title': 'Characterization and clinical relevance of circulating CD4+CD28− T cells in Graves’ disease', 'display_name': 'Characterization and clinical relevance of circulating CD4+CD28− T cells in Graves’ disease', 'publication_year': 2015, 'publication_date': '2015-05-01', 'ids': {'openalex': 'https://openalex.org/W2054894950', 'doi': 'https://doi.org/10.1016/j.imlet.2015.03.010', 'mag': '2054894950', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25839128'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.imlet.2015.03.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S71256826', 'display_name': 'Immunology Letters', 'issn_l': '0165-2478', 'issn': ['0165-2478', '1879-0542'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102892693', 'display_name': 'Wang Feng-ming', 'orcid': 'https://orcid.org/0000-0001-9182-7633'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fengming Wang', 'raw_affiliation_strings': ['Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China', 'Testing Center, Center for Disease Prevention and Control, Changzhou 213000, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Testing Center, Center for Disease Prevention and Control, Changzhou 213000, Jiangsu, China', 'institution_ids': []}, {'raw_affiliation_string': 'Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002230693', 'display_name': 'Lei Chen', 'orcid': 'https://orcid.org/0000-0002-9488-1173'}, 'institutions': [{'id': 'https://openalex.org/I4210116071', 'display_name': 'Suzhou Municipal Hospital', 'ror': 'https://ror.org/02cdyrc89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116071']}, {'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Lei Chen', 'raw_affiliation_strings': ['Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China', 'institution_ids': ['https://openalex.org/I4210116071', 'https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057851288', 'display_name': 'Qiong Shen', 'orcid': 'https://orcid.org/0000-0001-6313-3642'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210116071', 'display_name': 'Suzhou Municipal Hospital', 'ror': 'https://ror.org/02cdyrc89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116071']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiong Shen', 'raw_affiliation_strings': ['Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210116071']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100392625', 'display_name': 'Tong Liu', 'orcid': 'https://orcid.org/0000-0001-9152-5264'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tong Liu', 'raw_affiliation_strings': ['Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101703513', 'display_name': 'Jiang Lian', 'orcid': 'https://orcid.org/0000-0002-2491-6246'}, 'institutions': [{'id': 'https://openalex.org/I4210116071', 'display_name': 'Suzhou Municipal Hospital', 'ror': 'https://ror.org/02cdyrc89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116071']}, {'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lian Jiang', 'raw_affiliation_strings': ['Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China', 'institution_ids': ['https://openalex.org/I4210116071', 'https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101315374', 'display_name': 'Xinhua Gu', 'orcid': 'https://orcid.org/0009-0001-1230-9342'}, 'institutions': [{'id': 'https://openalex.org/I4210116071', 'display_name': 'Suzhou Municipal Hospital', 'ror': 'https://ror.org/02cdyrc89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116071']}, {'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinhua Gu', 'raw_affiliation_strings': ['Department of Gastrointestinal Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastrointestinal Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China', 'institution_ids': ['https://openalex.org/I4210116071', 'https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043103663', 'display_name': 'Lujun Chen', 'orcid': 'https://orcid.org/0000-0002-5410-9242'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lujun Chen', 'raw_affiliation_strings': ['Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100714101', 'display_name': 'Jing Sun', 'orcid': 'https://orcid.org/0000-0002-4161-6835'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Sun', 'raw_affiliation_strings': ['Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou 215007, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101758381', 'display_name': 'Cuiping Liu', 'orcid': 'https://orcid.org/0000-0002-7383-1505'}, 'institutions': [{'id': 'https://openalex.org/I4210153519', 'display_name': 'First Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/051jg5p78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153519']}, {'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cuiping Liu', 'raw_affiliation_strings': ['Clinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215007, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Clinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215007, Jiangsu, China', 'institution_ids': ['https://openalex.org/I4210153519', 'https://openalex.org/I3923682']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5002230693'], 'corresponding_institution_ids': ['https://openalex.org/I4210116071', 'https://openalex.org/I83519826'], 'apc_list': {'value': 3120, 'currency': 'USD', 'value_usd': 3120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.15, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.616799, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '165', 'issue': '1', 'first_page': '47', 'last_page': '51'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Innate Immune Recognition and Signaling Pathways', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thymic-selection', 'display_name': 'Thymic Selection', 'score': 0.480747}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.73352677}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6841517}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.63941246}, {'id': 'https://openalex.org/C148125776', 'wikidata': 'https://www.wikidata.org/wiki/Q1622348', 'display_name': 'CD28', 'level': 4, 'score': 0.5809465}, {'id': 'https://openalex.org/C137061746', 'wikidata': 'https://www.wikidata.org/wiki/Q736033', 'display_name': 'Peripheral blood mononuclear cell', 'level': 3, 'score': 0.5393524}, {'id': 'https://openalex.org/C2776652619', 'wikidata': 'https://www.wikidata.org/wiki/Q16483', 'display_name': "Graves' disease", 'level': 3, 'score': 0.53792286}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.4102638}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.38553166}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.31415474}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.25221348}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.20403585}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.1569154}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006111', 'descriptor_name': 'Graves Disease', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D006111', 'descriptor_name': 'Graves Disease', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001323', 'descriptor_name': 'Autoantibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001323', 'descriptor_name': 'Autoantibodies', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001323', 'descriptor_name': 'Autoantibodies', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018791', 'descriptor_name': 'CD4 Lymphocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019013', 'descriptor_name': 'CD40 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019013', 'descriptor_name': 'CD40 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006111', 'descriptor_name': 'Graves Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006111', 'descriptor_name': 'Graves Disease', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016130', 'descriptor_name': 'Immunophenotyping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011989', 'descriptor_name': 'Receptors, Thyrotropin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011989', 'descriptor_name': 'Receptors, Thyrotropin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060168', 'descriptor_name': 'Thymocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D060168', 'descriptor_name': 'Thymocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D060168', 'descriptor_name': 'Thymocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013972', 'descriptor_name': 'Thyrotropin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013972', 'descriptor_name': 'Thyrotropin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013974', 'descriptor_name': 'Thyroxine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013974', 'descriptor_name': 'Thyroxine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014284', 'descriptor_name': 'Triiodothyronine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014284', 'descriptor_name': 'Triiodothyronine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.imlet.2015.03.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S71256826', 'display_name': 'Immunology Letters', 'issn_l': '0165-2478', 'issn': ['0165-2478', '1879-0542'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25839128', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.75, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31170834'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31100634'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '30801023'}, {'funder': 'https://openalex.org/F4320321738', 'funder_display_name': 'Consejo de Ciencia y Tecnología del Estado de Tabasco', 'award_id': '20122008'}], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1505190407', 'https://openalex.org/W1509333421', 'https://openalex.org/W1667545291', 'https://openalex.org/W1871793426', 'https://openalex.org/W1965760510', 'https://openalex.org/W1971101894', 'https://openalex.org/W1976566016', 'https://openalex.org/W1977163758', 'https://openalex.org/W1980103583', 'https://openalex.org/W1987416293', 'https://openalex.org/W2008371222', 'https://openalex.org/W2009219510', 'https://openalex.org/W2032713375', 'https://openalex.org/W2033980269', 'https://openalex.org/W2045429967', 'https://openalex.org/W2048332099', 'https://openalex.org/W2053823901', 'https://openalex.org/W2056769769', 'https://openalex.org/W2059080130', 'https://openalex.org/W2060387930', 'https://openalex.org/W2078855785', 'https://openalex.org/W2082596386', 'https://openalex.org/W2086892531', 'https://openalex.org/W2094190721', 'https://openalex.org/W2145794149', 'https://openalex.org/W2149204478', 'https://openalex.org/W2162630148', 'https://openalex.org/W2171953655', 'https://openalex.org/W2173291386', 'https://openalex.org/W2181347453', 'https://openalex.org/W2267847880', 'https://openalex.org/W2286709234', 'https://openalex.org/W2440129025', 'https://openalex.org/W4236039148', 'https://openalex.org/W4239011555', 'https://openalex.org/W4254488601', 'https://openalex.org/W4256602179'], 'related_works': ['https://openalex.org/W3193529407', 'https://openalex.org/W2162856391', 'https://openalex.org/W2160124248', 'https://openalex.org/W2044402738', 'https://openalex.org/W2005978956', 'https://openalex.org/W1979841260', 'https://openalex.org/W1975332625', 'https://openalex.org/W1889753107', 'https://openalex.org/W1592696248', 'https://openalex.org/W1542374316'], 'abstract_inverted_index': {'During': [0], 'autoimmune': [1], 'disease': [2, 33, 269], 'the': [3, 10, 21, 106, 111, 127, 233, 240, 278], 'fraction': [4, 128], 'of': [5, 13, 42, 67, 93, 129, 150, 164, 194, 203, 225, 235, 242, 254, 280], 'CD4+CD28-': [6, 77, 100, 130, 165, 195, 236, 247, 262], 'T': [7, 131, 196], 'cells': [8, 78, 98, 132, 166, 197, 227, 256, 263], 'in': [9, 120, 135, 148, 169, 260, 264, 277], 'peripheral': [11, 24, 60], 'blood': [12, 25, 61], 'has': [14], 'been': [15], 'found': [16], 'to': [17], 'be': [18], 'elevated.': [19], 'In': [20], 'present': [22], 'study,': [23], 'was': [26, 72, 103, 133, 167], 'collected': [27], 'from': [28, 81], '61': [29, 151], 'patients': [30, 83, 137, 152, 170, 266], 'with': [31, 153, 171, 179, 200, 215, 268], "Graves'": [32, 154], '(GD)': [34], 'and': [35, 52, 59, 69, 87, 145, 187, 207, 246, 250, 271], '30': [36], 'healthy': [37, 139], 'control': [38], 'participants.': [39], 'Serum': [40], 'concentrations': [41], 'thyroid-stimulating': [43], 'hormone': [44], '(TSH),': [45], 'free': [46, 49], 'triiodothyronine': [47], '(FT3),': [48], 'thyroxine': [50], '(FT4)': [51], 'thyrotropin': [53], 'receptor': [54], 'autoantibody': [55], '(TRAb)': [56], 'were': [57, 79], 'measured': [58], 'mononuclear': [62], 'cell': [63, 101], '(PBMC)': [64], 'surface': [65], 'expression': [66], 'CD4': [68], 'CD28': [70], 'molecules': [71], 'detected': [73, 168], 'by': [74], 'flow': [75], 'cytometry.': [76], 'sorted': [80], 'six': [82], 'undergoing': [84], 'subtotal': [85], 'thyroidectomy': [86], 'cultured': [88], 'ex': [89], 'vivo.': [90], 'The': [91, 192, 258], 'influence': [92, 232], 'TSH': [94], 'pretreated': [95], 'thyroid': [96], 'follicular': [97], 'on': [99], 'proliferation': [102, 224, 234, 241, 253], 'evaluated': [104], 'using': [105], 'agonist': [107], 'CD40': [108], 'mAb': [109, 114, 118], '5C11,': [110], 'blocking': [112], 'CD40L': [113], '4F1': [115, 238], 'or': [116, 174, 218], 'B7-1': [117], '4E5': [119, 251], '3H-TdR': [121], 'assays.': [122], 'Our': [123], 'data': [124], 'showed': [125], 'that': [126], 'higher': [134, 162], 'GD': [136, 265], 'than': [138, 177], 'donors': [140], '(10.21%±8.56%': [141], 'vs.': [142, 158, 184, 189], '2.33%±1.94%;': [143], 'P<0.001),': [144], 'further': [146], 'elevated': [147], '24': [149], 'ophthalmopathy': [155], '(GO)': [156], '(7.00±6.57%': [157], '15.21±8.96%;': [159], 'P<0.001).': [160], 'A': [161], 'proportion': [163], 'degree': [172, 180], 'II': [173], 'III': [175], 'goiter': [176, 182], 'those': [178], 'I': [181], '(11.53±9.18%': [183], '6.11±3.97%;': [185, 190], 'P<0.05': [186], '14.50±10.41%': [188], 'P<0.01).': [191], 'percentage': [193], 'correlated': [198], 'positively': [199], 'serum': [201, 216], 'levels': [202], 'FT3': [204], '(r=0.354,': [205], 'P<0.01)': [206], 'TRAb': [208], '(r=0.304,': [209], 'P<0.05),': [210], 'but': [211, 229], 'did': [212, 230], 'not': [213, 231], 'correlate': [214], 'FT4': [217], 'TSH.': [219], 'Ex': [220], 'vivo,': [221], '5C11': [222], 'enhanced': [223], 'CD4+CD28+': [226, 244, 255], '(P<0.05),': [228], 'cells.': [237], 'inhibited': [239, 252], 'both': [243], '(P<0.05)': [245], '(P<0.01)': [248], 'cells,': [249], '(P<0.05).': [257], 'elevation': [259], 'circulating': [261], 'correlates': [267], 'severity': [270], 'maybe': [272], 'plays': [273], 'an': [274], 'important': [275], 'role': [276], 'pathogenesis': [279], 'GD.': [281]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054894950', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-13T07:50:42.501367', 'created_date': '2016-06-24'}