Identification of Cytoplasmic Domains of hVPAC1 Receptor Required for Activation of Adenylyl Cyclase

Name: Work Video:
Duration: 3 min 30 s
Alain Couvineau; J Lacapère; Yossan‐Var Tan; Christiane Rouyer‐Fessard; Pascal Nicole; Marc Laburthe
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3797, 3803, 3814, 3827, 3848, 3859, 3870, 3881, 3964, 3982, 4058, 4092, 4200, 4274, 4285, 4307, 4318, 4341, 4352], 'pituitary': [14, 321, 635, 687], 'adenylate': [15, 322, 636, 681, 688], 'cyclase-activating': [16, 323, 637, 689], 'peptide.': [17, 324], 'It': [18, 325, 705, 1635, 3276, 4223], 'is': [19, 42, 60, 183, 196, 326, 349, 367, 490, 503, 617, 1255, 1292, 2132, 2968, 3114, 3176, 3290, 3361, 3539, 3690, 4071, 4173, 4224], 'a': [20, 73, 131, 219, 294, 327, 380, 438, 526, 601, 618, 714, 769, 988, 1105, 1408, 1859, 2448, 2580, 2587, 2625, 2777, 2794, 2929, 3115, 3521, 3675, 3696, 3742, 3759, 3997, 4098, 4208, 4249], 'class': [21, 280, 300, 328, 587, 607, 875, 990, 1286, 1299, 1325, 1335, 1350, 1361, 1381, 2801, 2847], 'II': [22, 281, 301, 329, 588, 608, 876, 991, 1287, 1326, 1362, 2802, 2848], 'G': [23, 330, 657, 879], 'protein-coupled': [24, 331, 658, 880], 'receptor-activating': [25, 332], 'adenylyl': [26, 333, 749, 1273, 1400, 1467, 1653, 2128, 2137, 2143, 3041, 3158, 3325, 3372, 3377, 3414, 3708, 3782, 3798, 3804, 3843, 4018, 4082, 4130, 4181, 4276, 4308, 4336], 'cyclase': [27, 334, 682, 750, 1274, 1401, 1468, 1654, 2059, 2129, 2138, 2144, 3042, 3159, 3326, 3378, 3415, 3709, 3752, 3783, 3799, 3805, 3844, 4083, 4131, 4182, 4277, 4309, 4337], '(AC).': [28, 335], 'role': [30, 132, 166, 254, 296, 337, 439, 473, 561, 603, 1110, 3525, 4004, 4219], 'N-terminal': [33, 340, 982, 1098, 1151, 1217, 2630], 'extracellular': [34, 341, 983, 1099, 2631], 'domain': [35, 342, 1100, 1263, 2632], 'hVPAC1': [37, 266, 344, 573, 1102, 1210, 1220, 1266, 1396, 1560, 1706, 1809, 1930, 2694, 2769, 2961, 3037, 3181, 3274, 3369, 3628, 4012], 'for': [39, 67, 248, 268, 283, 346, 374, 555, 575, 590, 621, 886, 893, 1398, 1464, 1865, 1874, 1879, 1981, 2130, 2140, 2146, 2347, 2368, 2388, 2434, 2556, 2604, 2988, 3036, 3318, 3382, 3558, 3589, 3699, 3780, 3809, 4105, 4114, 4175, 4313], 'VIP': [40, 228, 347, 535, 773, 1008, 1112, 1508, 1648, 1946, 2024, 2073, 2111, 2125, 2205, 2343, 3155, 3171, 3328, 3381, 3590, 3667, 3700, 3748, 3808, 4079, 4127, 4185, 4215, 4272, 4301, 4312], 'binding': [41, 348, 1009, 1113, 1649, 1924, 1939, 2013, 2029, 2369, 2451, 3143, 3264, 3668, 3719, 3763, 3796, 4055, 4235, 4273], 'now': [43, 350], 'established': [44, 351], '(Laburthe,': [45, 352], 'M.,': [46, 353], 'Couvineau,': [47, 354], 'A.': [48, 355, 696, 727, 754, 803, 815, 836, 855, 917, 1014, 1026, 1047, 1058, 1079, 1117, 1129, 1156, 1180, 1229, 1241, 1538, 1540, 1569, 1618, 1660, 1683, 1724, 1757, 1795, 1899, 1901, 1951, 2087, 2089, 2160, 2233, 2284, 2512, 2524, 2539, 2649, 2661, 2676, 2996, 3594], 'Marie,': [50, 357], 'J.': [51, 358, 952, 1069, 1086, 1132, 1163, 1191, 1244, 1542, 1547, 1623, 1665, 1686, 1735, 1768, 1798, 1903, 1908, 1962, 2091, 2096, 2167, 2240, 2291, 2527, 2544, 2664, 2681, 3001, 3069, 3072], 'C.': [52, 359, 731, 819, 1030, 1060, 1081, 1119, 1158, 1182, 1231, 1532, 1534, 1571, 1620, 1662, 1726, 1759, 1893, 1895, 1953, 2081, 2083, 2162, 2235, 2286, 2514, 2541, 2651, 2678, 2998], '(2002)': [53, 360], 'Recept.': [54, 361, 699, 806, 1017, 3597], 'Channels': [55, 362], '8,': [56, 363], '137–153),': [57, 364], 'but': [58, 365, 3672, 3773], 'nothing': [59, 366, 1254], 'known': [61, 368, 1256], 'regarding': [62, 369, 1257, 1380], 'cytoplasmic': [64, 371], 'domains': [65, 372, 1010, 1365, 1428, 2939, 2952, 3056, 3080], 'responsible': [66, 373, 3035], 'AC': [68, 153, 177, 210, 231, 270, 289, 375, 460, 484, 517, 538, 577, 596], 'activation.': [69, 271, 376, 578, 1275, 1402, 1469], 'Here,': [70, 377], 'we': [71, 378, 1406, 3183, 3556, 4001, 4251], 'constructed': [72, 379, 1407, 4035, 4164], 'large': [74, 381, 715, 770, 979, 1409, 3540], 'series': [75, 382, 1410], 'mutants': [77, 110, 384, 417, 1412, 2131, 3127, 3213, 3241, 3253, 3285, 3314, 3388, 3643, 3653, 3671, 3815, 4033, 4091, 4162, 4233, 4282, 4319], 'by': [78, 107, 179, 185, 212, 385, 414, 486, 492, 519, 997, 1413, 1749, 1934, 1944, 2277, 2380, 2720, 2928, 2970, 3063, 3238, 3327, 3339, 3662], 'substituting': [79, 386, 1414], 'amino': [80, 104, 201, 387, 411, 508, 1146, 1417, 1421, 1448, 2712, 3047, 3107, 3121, 3543, 3564, 3632, 4043, 4118, 4153, 4170], 'acids': [81, 105, 388, 412, 1147, 1418, 1422, 1449, 2713, 3048, 3108, 3122, 3544, 3633, 4044, 4119, 4154], 'with': [82, 198, 303, 389, 505, 610, 762, 1003, 1296, 1334, 1423, 1608, 1645, 1710, 2195, 2204, 2264, 2340, 2359, 2420, 2427, 2559, 2568, 2616, 3138, 3303, 3356, 3541, 3715, 3769, 4074, 4144, 4269], 'alanine': [83, 390, 1424, 3052, 3398, 3408, 3496, 3638, 4022, 4048, 4111, 4330], 'in': [84, 111, 123, 136, 170, 187, 224, 229, 233, 238, 258, 279, 297, 391, 418, 430, 443, 477, 494, 531, 536, 540, 545, 565, 586, 604, 713, 1111, 1149, 1269, 1346, 1367, 1425, 1456, 1521, 1565, 1604, 1632, 1852, 1870, 1948, 1987, 2003, 2016, 2061, 2065, 2126, 2181, 2209, 2272, 2302, 2321, 2334, 2394, 2410, 2447, 2463, 2466, 2477, 2491, 2628, 2945, 3053, 3126, 3179, 3194, 3196, 3224, 3255, 3287, 3291, 3329, 3344, 3364, 3389, 3399, 3409, 3497, 3520, 3529, 3605, 3626, 3647, 3657, 3666, 3677, 3713, 3750, 3762, 3794, 3816, 3996, 4014, 4023, 4028, 4036, 4072, 4080, 4085, 4109, 4120, 4128, 4136, 4157, 4165, 4207, 4211, 4320, 4331], 'intracellular': [86, 393, 665, 1262, 1364, 1427, 2706, 3055, 3531], 'loops': [87, 394], '(IL)': [88, 395], '1,': [89, 396], '2,': [90, 397], '3': [92, 399, 1821, 3533, 4040], 'proximal': [94, 193, 262, 401, 500, 569, 1438, 3087, 4007, 4292, 4321], 'C-terminal': [95, 194, 263, 402, 501, 570, 1439, 1460, 1606, 2716, 3088, 4008, 4122, 4293, 4322], 'tail': [96, 195, 264, 403, 502, 571, 1461, 2717, 3089, 4009, 4294], 'receptor.': [99, 406, 685, 1211, 3275, 4069], 'mutation': [101, 204, 408, 511, 1442], '40': [103, 410, 1447, 3046], 'followed': [106, 413], 'expression': [108, 127, 151, 245, 415, 434, 458, 552, 1482, 1776, 3197], 'chinese': [112, 419], 'hamster': [113, 420], 'ovary': [114, 421], 'cells': [115, 240, 422, 547, 1791, 1816, 1849, 1978, 2178, 2191, 2262, 2325, 2355, 2385, 2493, 2501, 2553, 3137, 3163, 3257, 3289, 3649, 3659, 4087, 4138, 4145], 'showed': [116, 423, 1095], 'following.': [118, 425], '(i)': [119, 426], 'Mutations': [120, 427], 'IL1': [121, 428, 3175, 3390], 'result': [122, 429], 'absence': [125, 432, 1871, 2464], 'mutants,': [129, 436, 3555, 3758], 'suggesting': [130, 437], 'this': [134, 441, 1385, 1404, 2903, 4029, 4140], 'loop': [135, 442, 3532, 3538], 'folding.': [138, 445], '(ii)': [139, 446], 'All': [140, 447, 3251, 3652, 3670, 4052], 'residues': [141, 160, 257, 275, 448, 467, 564, 582, 1344, 1455, 2856, 3231, 3527, 3560, 3618, 3835, 3972, 4027, 4049], 'IL2': [143, 450, 3234, 3360], 'can': [144, 451], 'be': [145, 452, 1373, 3147, 3205, 3278, 3789], 'mutated': [146, 453, 1754, 1808, 1929, 3050, 3124, 3219, 3401, 3411, 3499, 3636, 3839, 3976, 4046, 4156, 4253, 4333], 'without': [147, 241, 454, 548, 2202], 'alteration': [148, 242, 455, 549, 4100, 4299], 'response': [154, 211, 237, 461, 518, 544, 2104, 3379, 3806, 4183, 4310], 'to': [155, 163, 462, 470, 721, 873, 890, 1005, 1208, 1289, 1369, 1466, 1647, 1842, 1940, 2638, 2800, 2830, 2842, 2901, 2947, 3016, 3030, 3040, 3156, 3170, 3269, 3321, 3336, 3371, 3380, 3550, 3792, 3807, 4017, 4047, 4064, 4167, 4184, 4227, 4238, 4271, 4311], 'VIP.': [156, 180, 249, 463, 487, 556, 2011, 2472], '(iii)': [157, 464], 'Mutation': [158, 465, 4188], 'IL3': [161, 259, 468, 566, 1457, 3568, 3820, 3957], 'points': [162, 469], 'specific': [165, 472, 2028], 'lysine': [168, 475, 3623], '322': [169, 476], 'efficacy': [172, 182, 226, 479, 489, 533, 2123, 3349, 3420, 3431, 3442, 3453, 3505, 3749, 3775, 3849, 3860, 3871, 3882, 3983, 4102, 4125, 4178, 4213, 4302, 4342, 4353], 'stimulation': [175, 482, 3323], 'activity': [178, 232, 485, 539, 2060, 2139, 2145, 3160, 3753, 3784, 4084, 4132, 4278], 'This': [181, 488, 3537, 3787, 4070], 'reduced': [184, 491], '50%': [186, 493, 3744, 4209], 'K322A': [189, 496, 3692, 3734], 'mutant.': [190, 497], '(iv)': [191, 498], 'equipped': [197, 504], 'another': [199, 506], 'important': [200, 507, 4226], 'acid': [202, 207, 509, 514, 3565, 4171], 'since': [203, 510], 'glutamic': [206, 513], '394': [208, 515, 4191, 4199], 'reduces': [209, 516], '50%.': [213, 520], 'double': [215, 522], 'mutant': [216, 523, 2331, 3724, 4107, 4141, 4259], 'K322A/E394A': [217, 524, 2319, 2330], 'exhibits': [218, 525], 'drastic': [220, 527], 'reduction': [221, 528], '>85%': [223, 530], 'stimulating': [230, 537, 2127, 3751, 4081, 4129], 'membranes': [234, 541, 1943, 1970, 2062], 'cAMP': [236, 543, 1880, 1921, 2152, 2270], 'intact': [239, 546, 2384], 'or': [246, 553, 691, 774, 901, 959, 1170, 1419, 1882, 2203, 2329, 2344, 2370, 3109, 3580, 4041, 4195], 'affinity': [247, 554, 3588, 3698, 3764], 'These': [250, 557, 1093, 2837, 3352, 3630], 'data': [251, 558, 2306, 2481, 3265, 3353, 3712], 'highlight': [252, 559], 'charged': [256, 274, 563, 581, 1454], 'agonist-induced': [269, 576], 'Because': [272, 579], 'these': [273, 580, 2912, 2941, 4230], 'are': [276, 286, 583, 593, 1462, 3221, 3354, 3654, 4061], 'absolutely': [277, 584], 'conserved': [278, 585, 1343, 2855, 3559, 3617, 3834, 3971], 'receptors': [282, 302, 589, 609, 881, 885, 892, 976, 1308, 1328, 1352, 1810, 2803, 2818, 2849, 2890, 3573, 4094], 'peptides,': [284, 591], 'which': [285, 592, 883, 2623, 3113, 3694, 3736, 3836, 3973, 4037, 4110, 4169], 'all': [287, 594, 1633, 3230, 3570], 'mediating': [288, 595], 'activation,': [290, 597], 'they': [291, 598, 767], 'may': [292, 599, 3187, 3788], 'play': [293, 600], 'general': [295, 602], 'coupling': [298, 605, 720, 1283, 1368, 1465, 3039, 3367, 4016], 'Gs': [305, 612, 722], 'protein.': [306, 613], 'common': [619], '1The': [626], 'abbreviations': [627], 'used': [628, 1631, 1676, 1841, 1878, 2367, 2841, 2985], 'are:': [629], 'VIP,': [630, 891, 2418], 'peptide;': [633, 638, 652, 655], 'PACAP,': [634], 'PTH,': [639, 899, 2810], 'parathyroid': [640], 'hormone;': [641], 'GRF,': [642, 2809], 'growth': [643, 789], 'hormone-releasing': [644], 'factor;': [645, 648], 'CRF,': [646, 2811], 'corticotropin-releasing': [647], 'GIP,': [649, 2815], 'Gastric': [650], 'inhibitory': [651], 'GLP,': [653], 'glucagon-like': [654], 'GPCR,': [656], 'receptor;': [659], 'GFP,': [660], 'green': [661, 1610], 'fluorescent': [662, 1611], 'protein;': [663], 'IL,': [664], 'loop;': [666], 'TM,': [667], 'transmembrane': [668, 2701, 2951], 'domain;': [669], 'HCA,': [670], 'hydrophobic': [671, 2925, 2938], 'cluster': [672, 2908], 'analysis;': [673], 'TRITC,': [674], 'tetramethylrhodamine': [675], 'isothiocyanate;': [676], 'VPAC,': [677], 'peptide/pituitary': [680], 'activating': [683], 'PACAP': [692, 775], '(1Laburthe': [693, 800, 1011, 3591], 'M.': [694, 725, 752, 801, 813, 834, 853, 906, 923, 962, 1012, 1024, 1045, 1068, 1085, 1125, 1131, 1162, 1190, 1237, 1243, 1546, 1581, 1622, 1664, 1734, 1767, 1907, 1961, 2095, 2166, 2239, 2290, 2520, 2526, 2543, 2657, 2663, 2680, 2756, 2758, 3000, 3592], 'Couvineau': [695, 726, 753, 802, 814, 835, 854, 1013, 1025, 1046, 1078, 1116, 1155, 1228, 1539, 1617, 1659, 1900, 2088, 2159, 2232, 2283, 2511, 2538, 2648, 2675, 2995, 3593], 'Marie': [697, 804, 1015, 3595], 'J.C.': [698, 805, 1016, 3596], 'Channels.': [700, 807, 1018, 3598], '2002;': [701, 757, 808, 839, 1019, 1050, 1089, 1166, 1320, 2170, 2243, 2294, 3599], '8:': [702, 809, 1020, 3600], '137-153Google': [703, 810, 1021, 3601], 'Scholar).': [704, 760, 868, 1092, 1138, 1250, 1323, 1553, 1589, 1671, 1741, 1774, 1804, 1914, 2102, 2173, 2246, 2297, 2550, 2687, 2763, 2792, 3007, 3078, 3602], 'actions': [708, 776], 'neuropeptides': [712], 'variety': [716], 'tissues': [718], 'through': [719], 'proteins': [723, 2942, 3220], '(2Laburthe': [724], 'Gaudin': [728, 816, 1027, 1063, 1185, 1729, 1762, 1956], 'P.': [729, 735, 817, 823, 929, 1028, 1034, 1064, 1066, 1083, 1121, 1160, 1186, 1188, 1233, 1528, 1536, 1614, 1656, 1730, 1732, 1763, 1765, 1889, 1897, 1957, 1959, 2077, 2085, 2164, 2237, 2288, 2516, 2535, 2653, 2672, 2992], 'Rouyer-Fessard': [730, 818, 1029, 1059, 1080, 1118, 1157, 1181, 1230, 1531, 1570, 1619, 1661, 1725, 1758, 1892, 1952, 2080, 2161, 2234, 2285, 2513, 2540, 2650, 2677, 2997], 'Maoret': [732, 820, 1031, 1061, 1122, 1183, 1234, 1574, 1615, 1657, 1727, 1760, 1954, 2517, 2536, 2654, 2673, 2993], 'J.J.': [733, 821, 1032, 1062, 1123, 1184, 1235, 1575, 1616, 1658, 1728, 1761, 1955, 2518, 2537, 2655, 2674, 2994], 'Nicole': [734, 822, 1033, 1065, 1082, 1120, 1159, 1187, 1232, 1731, 1764, 1958, 2163, 2236, 2287, 2515, 2652], 'Ann.': [736, 824, 1035], 'N.': [737, 825, 1036], 'Y.': [738, 826, 1037], 'Acad.': [739, 827, 1038], 'Sci.': [740, 828, 971, 1039], '1996;': [741, 829, 1040, 1072, 1194, 1738, 1771, 1965], '805:': [742, 830, 1041], '94-111Google': [743, 831, 1042], 'Scholar)': [744, 958, 975, 1053, 1169, 1197, 1629, 1692], 'subsequent': [746], 'activation': [747, 1651], '(3Laburthe': [751], 'Regul.': [755, 837, 1048], 'Peptides.': [756, 838, 1049], '108:': [758, 840, 1051], '165-173Google': [759, 841, 1052], 'Together': [761], 'VPAC2': [764, 3578], 'subtype,': [766], 'mediate': [768, 3322], 'array': [771], 'on': [777, 1787, 2497, 2579, 3096], 'exocrine': [778], 'secretions,': [779], 'release': [780], 'hormones,': [782], 'relaxation': [783], 'muscles,': [785], 'metabolism,': [786], 'immune': [787], 'functions,': [788], 'control': [790], 'fetuses': [792], 'tumor': [794], 'cells,': [795, 2619], 'embryonic': [797], 'brain': [798], 'development': [799], 'Scholar,': [811, 832, 842, 851, 913, 1022, 1043, 1075, 2533, 2670], '2Laburthe': [812, 1023], '3Laburthe': [833, 1044], '4Said': [843], 'S.I.': [844, 931], 'Trends': [845, 969], 'Endocrinol.': [846], 'Metab.': [847], '1991;': [848], '2:': [849], '107-112Google': [850], '5Laburthe': [852], 'Voisin': [856], 'T.': [857, 2737, 2739, 2752], 'Greeley': [858], 'G.H.': [859], 'Gastrointestinal': [860], 'Endocrinology.': [861], 'Humana': [862], 'Press': [863], 'Inc.,': [864], 'Totowa,': [865], 'NJ1999:': [866], '125-157Google': [867], 'belongs': [872], 'subfamily': [877], '(GPCR),': [882], 'includes': [884], 'peptides': [887, 895, 1207], 'structurally': [888], 'related': [889], 'other': [894, 4288], 'such': [896], 'as': [897, 1200, 1294, 1444, 1446, 1524, 1640, 1720, 1792, 1817, 1885, 1947, 2032, 2074, 2134, 2155, 2228, 2279, 2309, 2454, 2484, 2507, 2732, 2986, 3043, 3045, 3060, 3423, 3434, 3445, 3456, 3508, 3660, 3767, 3852, 3863, 3874, 3885, 3986, 4142, 4265, 4345, 4356], 'calcitonin,': [900], 'CRF': [902], '(6Ulrich': [903], 'C.D.': [904], 'Holtmann': [905], 'Miller': [907], 'L.J.': [908], 'Gastroenterology.': [909], '1998;': [910, 940, 955, 1626, 1668, 2547, 2684, 3004], '114:': [911], '382-397Google': [912], '7Harmar': [914], 'A.J.': [915, 949, 968], 'Arimura': [916], 'Gozes': [918], 'I.': [919, 1577, 2748], 'Journot': [920], 'L.': [921, 1115, 1227, 1530, 1891, 2079, 2510, 2647], 'Laburthe': [922, 1067, 1084, 1130, 1161, 1189, 1242, 1545, 1580, 1621, 1663, 1733, 1766, 1906, 1960, 2094, 2165, 2238, 2289, 2525, 2542, 2662, 2679, 2999], 'Pisegna': [924], 'J.R.': [925], 'Rawlings': [926], 'S.R.': [927], 'Robberecht': [928], 'Said': [930], 'Sreedharan': [932], 'S.P.': [933], 'Wank': [934], 'S.A.': [935], 'Washeck': [936], 'J.A.': [937], 'Pharmacol.': [938], 'Rev.': [939, 1316], '50:': [941], '265-270Google': [942], 'Scholar),': [943], 'so-called': [946], 'EGF-TM7': [947], '(8McKnight': [948], 'Gordon': [950, 965], 'S.': [951, 966], 'Leukoc.': [953], 'Biol.': [954, 1070, 1087, 1133, 1164, 1192, 1245, 1319, 1548, 1624, 1666, 1688, 1736, 1769, 1800, 1909, 1963, 2097, 2168, 2241, 2292, 2528, 2545, 2665, 2682, 3002, 3074], '63:': [956], '271-280Google': [957], 'LNB-TM7': [960], '(9Stacey': [961], 'Lin': [963], 'H-H.': [964], 'McKnight': [967], 'Biochem.': [970, 1582], '2000;': [972, 1550, 1911, 2099, 2760], '25:': [973], '284-289Google': [974], 'bearing': [977], 'unusually': [978], 'complex': [981], 'domains.': [984], 'receptor,': [987, 992, 2635, 3182, 4243], 'prototypical': [989, 1304], 'has': [993, 1222, 1636, 3235, 3695, 4260], 'been': [994, 1223, 3101, 3236, 3838, 3975], 'extensively': [995], 'studied': [996], 'site-directed': [998, 1501], 'mutagenesis': [999, 1502, 1717], 'molecular': [1001, 3033], 'chimerism': [1002], 'respect': [1004, 1646, 4270], 'determination': [1006, 1358], 'agonist': [1055], 'selectivity': [1056, 1201], '(10Couvineau': [1057, 1179, 1723, 1756], 'Chem.': [1071, 1088, 1134, 1165, 1193, 1246, 1549, 1625, 1667, 1737, 1770, 1910, 1964, 2098, 2169, 2242, 2293, 2529, 2546, 2666, 2683, 3003], '271:': [1073, 1195, 1739, 1772, 1966], '12795-12800Google': [1074, 1196, 1740, 1773, 1967], '11Du': [1076], 'K.': [1077, 1154, 2158, 2231, 2282, 2735], '277:': [1090, 1167, 2171, 2244, 2295], '37016-37022Google': [1091, 1168, 2172, 2245, 2296], 'studies': [1094, 2496, 2615], 'that': [1096, 1297, 1452, 3185, 3217, 3270, 3281, 3337, 3359, 3725, 4060, 4229], 'plays': [1104], 'crucial,': [1106], 'although': [1107], 'not': [1108, 2345, 3222, 3362, 4296], 'exclusive,': [1109], '(12Lins': [1114, 1226, 2509, 2646], 'Benhamed': [1124, 1236, 2519, 2656], 'Brasseur': [1126, 1238, 1543, 1904, 2092, 2521, 2658], 'R.': [1127, 1239, 1544, 1905, 2093, 2522, 2659, 3071], 'Thomas': [1128, 1240, 1537, 1898, 2086, 2523, 2660], '2001;': [1135, 1247, 2530, 2667], '276:': [1136, 1248, 2531, 2668], '10153-10160Google': [1137, 1249, 2532, 2669], 'Moreover,': [1139], 'microdomains': [1140], 'consisting': [1141, 2697], 'small': [1143], 'clusters': [1144, 2926], 'located': [1148], 'ectodomain': [1152, 1218], '(11Du': [1153, 2157, 2230, 2281], 'at': [1171, 1858, 1984, 2254, 2350, 2391, 2437, 2642], 'junction': [1173], 'extraloop': [1175], '1': [1176, 1875, 2225, 2265, 2360, 2421, 2469, 3247], 'TM3': [1178], 'were': [1198, 1475, 1496, 1517, 1556, 1677, 1811, 1850, 1932, 1979, 2048, 2106, 2116, 2179, 2192, 2199, 2307, 2332, 2338, 2356, 2378, 2386, 2482, 2505, 2554, 2577, 2823, 2835, 2840, 2914, 2943, 3011, 3049, 3123, 3315, 3334, 3421, 3432, 3443, 3454, 3506, 3634, 3850, 3861, 3872, 3883, 3984, 4034, 4045, 4155, 4163, 4343, 4354], 'characterized': [1199], 'filters': [1202, 2596], 'restricting': [1203], 'access': [1204], 'VIP-related': [1206], 'A': [1212, 1590, 3393, 3403, 3491, 4325], 'three-dimensional': [1213, 1702, 2690], 'model': [1214, 1703, 2691, 3025], 'recently': [1224, 2725], 'developed': [1225], 'In': [1251, 1384, 2610, 2793, 2825, 2899, 3028, 3548], 'sharp': [1252], 'contrast,': [1253], 'regions': [1259], 'involved': [1268, 1366, 3363], 'signal': [1270, 1290, 1370], 'transduction': [1271, 1291, 1371], 'e.g.': [1272], 'More': [1276], 'generally,': [1277], 'current': [1279, 1378], 'knowledge': [1280, 1379], 'mechanism': [1284], 'GPCRs': [1288, 1301, 1337], 'limited': [1293], 'compared': [1295, 2915, 3768, 4143], 'I': [1300, 1336, 1351, 1382], 'including': [1302, 1353, 1432, 2804, 4244], 'rhodopsin': [1305, 2731, 2771, 2831, 2965], 'β-adrenergic': [1307], '(13Pierce': [1309], 'K.L.': [1310], 'Premont': [1311], 'R.T.': [1312], 'Lefkowitz': [1313], 'R.J.': [1314], 'Nat.': [1315], 'Mol.': [1317, 1687, 1799, 3073], 'Cell.': [1318], '3:': [1321], '639-650Google': [1322], 'Since': [1324, 3174, 4151], 'have': [1329, 3100, 3188, 3674, 3837, 3974, 4234], 'low': [1330, 3582, 3697, 4177], 'overall': [1331], 'sequence': [1332, 1597, 3609], 'identity': [1333, 2971], 'even': [1339], 'lack': [1340], 'rigorously': [1342], 'found': [1345], 'core': [1348], '(D/E)RY': [1355], 'sequence,': [1356], 'cannot': [1372], 'simply': [1374], 'extrapolated': [1375], 'from': [1376, 1477, 1485, 1497, 1505, 1510, 1557, 1678, 1696, 1976, 2819, 2832, 3569, 3727, 3821, 3958], 'our': [1377, 1522, 1566, 2614], 'GPCRs.': [1383], 'context,': [1386, 3098], 'present': [1388, 2271, 3528], 'study': [1389], 'explores': [1390], 'structure-function': [1392], 'relationship': [1393], 'VIP-induced': [1399], 'For': [1403, 3756], 'purpose,': [1405], 'groups': [1415, 3105], 'individual': [1420], 'IL1,': [1433, 3082, 3112], 'IL2,': [1434, 3083], 'IL3,': [1435, 3084], 'tail.': [1440, 4123], 'many': [1445, 3044], 'provides': [1450], 'evidence': [1451], 'mandatory': [1463], 'Materials—Restriction': [1470], 'enzymes': [1471], 'culture': [1473, 2185], 'medium': [1474, 2186, 2258], 'obtained': [1476, 1748], 'Invitrogen': [1478], '(Cergy-Pontoise,': [1479], 'France).': [1480, 1513, 2922], 'Eukaryotic': [1481], 'vector': [1483], 'was': [1484, 1504, 1509, 1563, 1630, 1694, 1708, 1718, 1747, 1780, 1840, 2014, 2030, 2063, 2153, 2187, 2259, 2275, 2300, 2445, 2452, 2475, 2718, 2774, 2984, 3026, 3150, 3534, 3731, 3765, 3778, 4103, 4112, 4133], 'Clontech': [1486], '(Palo': [1487], 'Alto,': [1488], 'CA).': [1489, 2057], 'DNA': [1490, 1833], 'Sequenase': [1491], 'kit': [1492, 1503], 'radioactive': [1494], 'reagents': [1495], 'Amersham': [1498], 'Biosciences.': [1499], 'Promega.': [1506], 'Synthetic': [1507, 1554], 'Neosystem': [1511], '(Strasbourg,': [1512], '125I-VIP': [1514, 1938, 2462, 3145, 3259], '125I-cAMP': [1516], 'prepared': [1518, 1975], 'purified': [1520, 1674], 'laboratory': [1523, 1567], 'previously': [1525, 1721, 1818, 1886, 3061], 'described': [1526, 1722, 1793, 1819, 1887, 2075, 2156, 2229, 2280, 2508, 3424, 3435, 3446, 3457, 3509, 3718, 3853, 3864, 3875, 3886, 3987, 4346, 4357], '(14Nicole': [1527, 1888, 2076], 'Lins': [1529, 1890, 2078], 'Drouot': [1533, 1894, 2082], 'Fulcrand': [1535, 1896, 2084], 'Martinez': [1541, 1902, 2090], '275:': [1551, 1912, 2100], '24003-24012Google': [1552, 1913, 2101], 'oligonucleotides': [1555], 'Invitrogen.': [1558], 'cDNA': [1562], 'cloned': [1564], '(15Couvineau': [1568], 'Darmoul': [1572], 'D.': [1573], 'Carrero': [1576], 'Ogier-Denis': [1578], 'E.': [1579], 'Biophys.': [1583], 'Res.': [1584, 2788], 'Commun.': [1585], '1994;': [1586, 2789], '200:': [1587], '769-776Google': [1588], 'construct': [1592], 'containing': [1593, 1994, 2215, 2401], 'an': [1594, 2020, 3620, 3738], 'inserted': [1595, 2627], 'FLAG': [1596, 2562, 2626], 'between': [1598, 2035, 2457, 2767, 2959, 3294], 'Ala30': [1599], 'Ala31': [1601], 'fused': [1603], 'position': [1607], 'protein': [1612, 3300], '(16Gaudin': [1613, 1655, 2991], '273:': [1627, 1669, 2548, 2685, 3005], '4990-4996Google': [1628, 1670, 2549, 2686, 3006], 'studies.': [1634, 2372], 'same': [1638, 4263], 'phenotype': [1639, 4264], 'wild-type': [1642, 1927, 2147, 2327, 3166, 3273, 3308, 3341, 3383, 3683, 3729, 3771, 3810, 4068, 4093, 4147, 4242, 4267, 4314], 'native': [1643, 2072], 'Other': [1672, 4281], 'highly': [1673], 'chemicals': [1675], 'Sigma.': [1679], 'Modeler': [1680, 2989, 3018], 'v6.0': [1681, 2990], '(17Sali': [1682, 1794], 'Blundell': [1684, 1796], 'T.L.': [1685, 1797], '1993;': [1689, 1801], '234:': [1690, 1802], '779-815Google': [1691, 1803], 'software': [1693, 1712, 2052, 2918], 'downloaded': [1695], 'salilab.org/modeler/.': [1697], 'Graphical': [1698], 'representation': [1699], 'performed': [1709, 1719, 2775, 3237], 'VMD': [1711], '(www.ks.uiuc.edu/Research/vmd/).': [1713], 'Site-directed': [1714], 'Mutagenesis': [1715], 'Experiments—Oligonucleotide-directed': [1716], 'Identification': [1742], 'desired': [1745], 'mutations': [1746, 3099, 3186], 'direct': [1750, 1783], 'sequencing': [1751], 'region': [1755], 'Correct': [1775], 'each': [1778, 2858], 'construction': [1779], 'determined': [1781, 1933, 2015, 2301, 2379, 2446, 2476, 2506, 2726, 3422, 3433, 3444, 3455, 3507, 3665, 3851, 3862, 3873, 3884, 3985, 4344, 4355], 'par': [1782], 'fluorescence': [1784, 1839, 2490, 3203], 'GFP': [1786, 1838, 2489, 2605, 3202], 'living': [1788, 2492, 2618], 'transfected': [1789, 1813, 1847, 1941, 1977, 2176, 2499, 3225], 'CHO': [1790, 1815, 1848, 2177, 2322, 2324, 2500, 3136, 3162, 3256, 3288, 3648, 3658, 4086, 4137], 'Cell': [1805, 2298, 2473], 'Transfection—Wild-type': [1806], 'stably': [1812, 2175, 2498], 'into': [1814, 3051, 3637, 3840, 3977], 'using': [1820, 2050, 2118, 2502, 2586, 2723, 2776, 2916], 'μl': [1822, 2429], 'FuGENE': [1824], '6': [1825], '(Roche': [1826], 'Applied': [1827], 'Science)': [1828], '2': [1830, 2348], 'μg': [1831, 1972], 'construct.': [1834], 'After': [1835, 2353, 3133], '48': [1836], 'h,': [1837], 'check': [1843], 'expression,': [1845], 'selected': [1851], 'presence': [1854, 2005, 2018, 2067, 2412, 2467, 3396, 3406, 3494, 3613, 4328], 'Geneticin': [1856], '(G418)': [1857], 'final': [1860, 2957], 'concentration': [1861], '0.8': [1863], 'g/liter': [1864], '5': [1866, 2341], 'days,': [1867], 'then': [1868, 2200, 2567], 'grown': [1869, 2180, 2333], 'G418': [1873], 'week,': [1876], 'measurement': [1881], 'membrane': [1883, 2645, 3330], 'preparation': [1884], 'Ligand': [1915], 'Binding,': [1916], 'Adenylyl': [1917, 2058], 'Cyclase,': [1918], 'Intracellular': [1920, 2151], 'Assays—': [1922], 'properties': [1925], 'competitive': [1935], 'inhibition': [1936], 'cell': [1942], 'unlabeled': [1945, 2010, 2023, 2417, 2471], 'Ref.': [1949], '10Couvineau': [1950], 'Scholar.': [1968], 'Briefly,': [1969, 2174, 2383, 2551, 2764, 2923], '(200': [1971], 'protein)': [1974], 'incubated': [1980, 2201, 2387, 2555], '60': [1982, 2389], 'min': [1983, 2253, 2390, 2436, 2558], '30': [1985, 2557], '°C': [1986, 2393], '20': [1988, 2395, 4026], 'mm': [1989, 2226, 2396], 'HEPES': [1990, 2397], 'buffer,': [1991, 2398], 'pH': [1992, 2399], '7.4,': [1993, 2400], '2%': [1995, 2216, 2402], '(w/v)': [1996, 2217, 2222, 2403], 'bovine': [1997, 2218, 2404, 2866, 2964], 'serum': [1998, 2219, 2405], 'albumin': [1999], '0.05': [2001, 2408], 'nm125I-VIP': [2002, 2409], 'increasing': [2007, 2069, 2414], 'concentrations': [2008, 2070, 2109, 2415], 'Nonspecific': [2012], 'excess': [2021], '(1': [2025], 'μm).': [2026], 'calculated': [2031, 2117, 2308, 2453, 2483], 'difference': [2034, 2456], '125I-peptide': [2036], 'totally': [2037], 'bound': [2038, 2461, 3258], 'nonspecific': [2041], 'binding.': [2042], 'Binding': [2043, 2373], 'parameters': [2044, 2374, 3375, 3802, 4056, 4236, 4306], '(Kd': [2045, 2375, 3701, 4057], 'Bmax)': [2047, 2377, 4059], 'analyzed': [2049, 3644], 'Prism': [2051, 2120], '(GraphPad': [2053], 'Software,': [2054], 'San': [2055], 'Diego,': [2056], 'measured': [2064, 2276], 'Dose': [2103], 'curves': [2105], 'fitted,': [2107], 'giving': [2112], 'half-maximal': [2113], 'responses': [2114, 3333], '(EC50)': [2115], 'Software.': [2121], 'defined': [2133, 3062], '(VIP': [2135], '(10–6m)-stimulated': [2136, 2142], 'mutant/VIP': [2141], 'receptor)': [2148], '×': [2149], '100.': [2150], 'assayed': [2154], '12-well': [2182], 'trays,': [2183], 'discarded,': [2188], 'adherent': [2190], 'gently': [2193], 'rinsed': [2194], 'phosphate-buffered': [2196, 2213], 'saline.': [2197], 'They': [2198], 'under': [2206, 3425, 3436, 3447, 3458, 3510, 3854, 3865, 3876, 3887, 3988, 4347, 4358], 'continuous': [2207], 'agitation': [2208], '0.5': [2210], 'ml': [2211, 2361, 2422], 'saline': [2214, 2364], 'albumin,': [2220, 2406], '0.1%': [2221], 'bacitracin,': [2223], '3-isobutyl-1-methylxanthine': [2227], 'At': [2247], 'end': [2249], 'incubation': [2251], '(30': [2252], '25': [2255, 2392, 2438], '°C)': [2256], 'removed': [2260], 'lysed': [2263], 'm': [2266, 2432], 'perchloric': [2267], 'acid.': [2268], 'lysate': [2274], 'radioimmunoassay': [2278], 'number': [2299, 2474, 2485, 3553], 'parallel': [2303, 2478], 'wells,': [2304, 2479], 'pmol': [2310], 'cAMP/106': [2312], 'cells.': [2313, 3226], 'Internalization': [2314], 'Wild-type': [2316], 'Receptor': [2317], 'Mutant': [2320], 'Cells—Subconfluent': [2323], 'expressing': [2326, 3164, 4088, 4139, 4146], '24-well': [2335], 'plates.': [2336], 'Cells': [2337], 'treated': [2339], 'nm': [2342], '(control)': [2346], 'h': [2349], '37': [2351], '°C.': [2352], 'treatment,': [2354], 'washed': [2357, 2419], 'twice': [2358], 'phosphate-buffer': [2363, 2424], 'subsequently': [2366], 'immunofluorescence': [2371, 2495], 'Scatchard': [2381, 3261], 'analysis.': [2382], 'saline,': [2425], 'solubilized': [2426], '300': [2428], '0.25': [2431], 'NaOH': [2433], '10': [2435], '°C,': [2439], 'amount': [2442, 2459], 'radioactivity': [2444], 'γ-counter.': [2449], 'Specific': [2450], 'μm': [2470], 'sites/cell.': [2487], 'anti-FLAG': [2503, 2621], 'antibodies': [2504], '16Gaudin': [2534, 2671], 'primary': [2561, 2772], 'mouse': [2563], 'monoclonal': [2564], 'antibody': [2565, 2571], 'secondary': [2570], '(TRITC-sheep': [2572], 'antimouse': [2573], 'IgG).': [2574], 'Selected': [2575], 'fields': [2576], 'examined': [2578], 'LEICA': [2581], 'inverted': [2582], 'DM': [2583], 'IRB': [2584], 'microscope': [2585], '(×40)': [2588], 'fluor': [2589], 'oil': [2590], 'immersion': [2591], 'objective': [2592, 3019], 'N2.1': [2597], '(515–590-nm': [2598], 'bandpass)': [2599, 2603], 'L5': [2601], '(480–527-nm': [2602], 'TRITC': [2607], 'fluorescence,': [2608], 'respectively.': [2609], 'conditions': [2612], 'nonpermeabilized': [2617], 'antibodies,': [2622], 'recognize': [2624], 'only': [2636, 3022, 3723], 'bind': [2637], 'constructs': [2640, 4053], 'expressed': [2641, 3223, 3254, 3286, 3656], 'plasma': [2644], 'Molecular': [2688], 'Modeling—A': [2689], '(136–411)': [2696], 'seven': [2700, 2950], 'domains,': [2702], 'three': [2703, 3240, 3252, 3313, 4117, 4152], 'extra-': [2704], 'loops,': [2707], 'first': [2710, 2795, 3024, 4025, 4116], '18': [2711], 'built': [2719], 'comparative': [2721], 'modeling': [2722], '2.8-Å': [2727], 'x-ray': [2728], 'structure': [2729, 3192], 'template': [2733], '(18Palczewski': [2734], 'Kumasaka': [2736], 'Hori': [2738], 'Behnke': [2740], 'C.A.': [2741], 'Motoshima': [2742], 'H.': [2743], 'Fox': [2744], 'B.A.': [2745], 'Le': [2746], 'Trong': [2747], 'Teller': [2749], 'D.C.': [2750], 'Okada': [2751], 'Stenkamp': [2753], 'R.E.': [2754], 'Yamamoto': [2755], 'Miyano': [2757], 'Science.': [2759], '289:': [2761], '739-745Google': [2762], 'preliminary': [2765], 'alignment': [2766, 2958, 2983, 3610, 3818, 3955], 'sequences': [2773, 2798, 2828, 2913, 2935, 3566], 'Clustal': [2778], 'algorithm': [2779], '(19Thompson': [2780], 'J.D.': [2781], 'Higgins': [2782], 'D.G.': [2783], 'Gibson': [2784], 'T.J.': [2785], 'Nucleic': [2786], 'Acids': [2787], '22:': [2790], '4673-4680Google': [2791], 'step,': [2796], '53': [2797], 'corresponding': [2799, 2829, 3140], 'VPAC1,': [2805, 2885, 3823, 3960], 'VPAC2,': [2806, 2886, 3824, 3961], 'PAC1,': [2807, 2888, 3825, 3962], 'secretin,': [2808, 2887, 3584, 3826, 3963], 'GLP-1,': [2812], 'GLP-2,': [2813], 'glucagon,': [2814], 'calcitonin': [2817], 'several': [2820], 'species': [2821, 2834], '(www.gpcr.org/7tm/)': [2822], 'aligned.': [2824, 2836], 'parallel,': [2826], '83': [2827], 'different': [2833], 'alignments': [2839], 'select': [2843], 'five': [2844], 'members': [2845], 'opsins': [2851], 'sharing': [2852], 'highest': [2854], 'within': [2857], 'family.': [2859], 'next': [2861], 'step': [2862], 'consisted': [2863], 'aligning': [2865], 'OPSD': [2867, 2875], '(PDB': [2868, 2966], '1F88)': [2869, 2967], 'human': [2871, 2884, 3384, 3571, 3811, 3822, 3959, 4315], 'OPSB,': [2872], 'OPSG,': [2873], 'OPSR,': [2874], '(NCB': [2876, 2891], 'accession': [2877, 2892], 'P03999,': [2878], 'P04001,': [2879], 'P04000,': [2880], 'P08100,': [2881], 'respectively)': [2882], 'GRF': [2889, 3586, 3828, 3965], 'P32241,': [2893], 'P41587,': [2894], 'P47872,': [2895], 'P41586,': [2896], 'Q02643,': [2897], 'respectively).': [2898], 'order': [2900, 2946, 3029, 3549, 4166], 'refine': [2902], 'alignment,': [2904], 'HCA': [2906, 2978], '(hydrophobic': [2907], 'analysis)': [2909], 'plots': [2910, 3067], 'VisualFasta': [2917], '(Patrick': [2919], 'Durand,': [2920], 'Paris,': [2921], 'visualized': [2927], 'two-dimensional': [2930], 'helical': [2931], 'plot': [2932], 'detecting': [2936], 'aligned': [2944, 3562], 'make': [2948], 'coincident.': [2953], 'quality': [2955], 'evaluated': [2969], 'score': [2972, 2975, 2979], '(14%),': [2973], 'homology': [2974], '(61%),': [2976], '(64%).': [2980], 'resulting': [2982, 3125, 3193], 'input': [2987], 'Two': [3008], 'hundred': [3009], 'models': [3010], 'generated': [3012], 'ranked': [3014], 'according': [3015], 'function,': [3020], 'used.': [3027], 'determine': [3031, 4168], 'motif(s)': [3034], 'Kyte-Doolittle': [3065], 'hydropathicity': [3066], '(20Kyte': [3068], 'Doolittle': [3070], '1982;': [3075], '157:': [3076], '105-132Google': [3077], 'Mutated': [3079], 'include': [3081], '(Fig.': [3093, 3246], '1).': [3094, 3547], 'Depending': [3095], 'carried': [3102], 'out': [3103], 'per': [3104], 'individually.': [3110], 'Regarding': [3111], 'short': [3116, 3178], 'loop,': [3117], 'blocks': [3119, 4038], 'IL11': [3128, 3210], 'IL12': [3130, 3212], '(Table': [3131, 3172, 3310, 3350, 3650, 3685, 3754, 3785, 4050, 4095, 4149, 4186, 4246, 4279, 4303], 'I).': [3132, 3173, 3250, 3311, 3351], 'transfection': [3134, 3208, 3646], 'cDNAs,': [3141], 'no': [3142, 3201], 'could': [3146, 3204], 'detected.': [3148, 3517], 'Nor': [3149], 'there': [3151], 'any': [3152, 4298], 'ability': [3153, 3320], 'stimulate': [3157], 'whereas': [3161], 'responded': [3168], 'nicely': [3169], 'very': [3177, 3581, 4062], 'reasoned': [3184], 'grossly': [3189], 'altered': [3190], 'problems': [3195], 'mutants.': [3199], 'Indeed,': [3200, 3721], 'detected': [3206], 'after': [3207, 3645], '(not': [3214], 'shown)': [3215], 'supporting': [3216], 'Next,': [3227], 'substitution': [3228], 'constructing': [3239], 'IL21,': [3242], 'IL22,': [3243], 'IL23': [3245], 'Table': [3249, 3606], 'analysis': [3262], 'revealed': [3266], 'affinities': [3267], 'similar': [3268, 4063, 4076], 'should': [3277], 'also': [3279, 4205, 4252], 'noted': [3280], 'Bmax': [3283, 3305, 3664, 4245], 'range': [3293, 3680], '461': [3295], '580': [3297], 'fmol/mg': [3298], 'comparing': [3301], 'well': [3302], 'further': [3316, 4161], 'investigated': [3317, 3535, 4002], 'their': [3319, 3663], 'preparations.': [3331], 'identical': [3335, 4237], 'mediated': [3338], 'both': [3343, 4197], 'terms': [3345], 'EC50': [3347, 3740, 4077], 'consistent': [3355], 'fact': [3358], 'functional': [3366], 'cyclase.Table': [3373], 'IBinding': [3374], 'IL2IL1aBold': [3392], 'represents': [3394, 3404, 3492, 4326], 'receptors.IL2aBold': [3402], 'receptors.169-KHLCTRN-175wt245-AVSFFSERKY-254wt169-AAAATRN-175IL11245-AAAAFSERKY-254IL21169-KLHCAAA-175IL12245-AVSFAAAAKY-254IL22245-AVSFFSERAA-254IL23Mutants125I-VIP': [3412], 'bindingVIP-stimulated': [3413, 3842, 4335], 'activityKdbKd,': [3416, 3845, 4338], 'Bmax,': [3417, 3428, 3439, 3450, 3502, 3846, 3857, 3868, 3879, 3980, 4339, 4350], 'EC50,': [3418, 3429, 3440, 3451, 3503, 3847, 3858, 3869, 3880, 3981, 4340, 4351], '"Experimental': [3426, 3437, 3448, 3459, 3511, 3855, 3866, 3877, 3888, 3989, 4348], 'Procedures."BmaxbKd,': [3427, 3856, 4349], 'Procedures."EC50bKd,': [3438, 3867], 'Procedures."EfficacybKd,': [3449, 3878], 'Procedures."nMfmoles/mg': [3460, 3889], 'prot.nM%WtcWt,': [3462, 3891], 'wild': [3463, 3514, 3892, 3992], 'type.0.36': [3464, 3893], '±': [3465, 3467, 3469, 3472, 3474, 3476, 3478, 3480, 3482, 3484, 3486, 3488, 3704, 3894, 3896, 3898, 3900, 3902, 3904, 3906, 3908, 3910, 3912, 3914, 3916, 3918, 3920, 3922, 3924, 3926, 3928, 3930, 3932, 3934, 3936, 3938, 3940, 3942, 3944, 3946, 3948, 3950, 3952], '0.02561': [3466, 3895], '950.24': [3468, 3897], '0.05100IL11NDdNot': [3470], 'detected.NDNDNDIL12NDNDNDNDIL211.05': [3471], '0.40580': [3473], '1010.18': [3475], '0.0790IL220.96': [3477], '0.29461': [3479], '930.44': [3481], '0.1389IL230.86': [3483], '0.31576': [3485], '1570.27': [3487], '0.06100a': [3489], 'Bold': [3490, 3830, 3967], 'receptors.b': [3500], 'Kd,': [3501, 3979], 'Procedures."c': [3512, 3990], 'Wt,': [3513, 3991], 'type.d': [3515], 'Not': [3516], 'Open': [3518, 3994], 'table': [3519, 3995], 'new': [3522, 3998], 'tab': [3523, 3999], 'next.': [3536], '26': [3542], '(see': [3545], 'Fig.': [3546], 'limit': [3551], 'searched': [3557], 'Gs-coupled': [3572], 'having': [3574], 'high': [3575], '(VPAC1': [3576], 'receptors)': [3579, 3587], '(PAC1,': [3583], 'As': [3603, 4248], 'shown': [3604], 'II,': [3607], 'reveals': [3611], 'eight': [3615], 'strictly': [3616, 3833, 3970], 'arginine': [3621], 'versus': [3622], 'exchange': [3624], '(Arg341': [3625], 'receptor).': [3629], 'nine': [3631], 'individually': [3635], 'phenotypes': [3641], 'II).': [3651, 3686, 3755, 3786], 'functionally': [3655], 'assessed': [3661], 'experiments.': [3669], 'one': [3673], 'Kd': [3676], 'nanomolar': [3679], 'like': [3681], 'notable': [3688], 'exception': [3689], 'mutant,': [3693, 3735], '=': [3702], '23.4': [3703], '4.0': [3705], 'nm).': [3706], 'assay': [3710], 'provided': [3711], 'agreement': [3714], 'above': [3717], 'data.': [3720], 'differed': [3726], 'again': [3732, 4225], 'exhibited': [3737, 4054], 'increased': [3739], 'significant': [3743, 4099], 'decrease': [3745, 3761, 4210], 'some': [3757], 'slight': [3760], 'observed': [3766, 4104], 'full': [3774], 'potency': [3777], 'maintained': [3779], 'VIP-stimulated': [3781, 4275], 'tentatively': [3790], 'ascribed': [3791], 'differences': [3793], 'assays.Table': [3800], 'IIBinding': [3801], 'IL3IL3aSequence': [3817], 'receptors.': [3829, 3966], 'characters': [3831, 3968], 'represent': [3832, 3969], 'alanine.317-RILLQKLRPPDIRKSDSSPYSRLARS-342hVPAC1304-RILLQKLTSPDVGGNDQSQYKRLAKS-329hVPAC2386-VILVQKLQSPDMGGNESSIYLRLARS-411hPAC1318-RILMRKLRTQETRGNEVSHYKRLARS-343hSecretin-R305-RILVRKLEPAQGSLHTQSQYWRLSKS-330hGRF-RMutants125I-VIP': [3841], '0.05100I318A3.23': [3899], '0.32656': [3901], '1730.26': [3903], '0.0395L319A5.32': [3905], '2.32555': [3907], '1370.22': [3909], '0.0390K322A23.44': [3911], '4.00828': [3913], '1742.03': [3915], '0.4052L323A1.40': [3917], '0.53677': [3919], '960.38': [3921], '0.0385Y336A2.44': [3923], '0.40486': [3925], '1010.8': [3927], '0.0790R338A4.38': [3929], '0.72309': [3931], '1300.63': [3933], '0.0484L339A1.91': [3935], '0.64238': [3937], '560.21': [3939], '0.0690R341A2.17': [3941], '0.12200': [3943], '100.32': [3945], '0.0289S342A0.77': [3947], '0.11356': [3949], '140.39': [3951], '0.1783a': [3953], 'Sequence': [3954], 'alanine.b': [3978], 'type.': [3993], 'Then,': [4000], 'cyclase.': [4019], 'We': [4020], 'substituted': [4021, 4113], 'domain.': [4030], 'First,': [4031], 'four': [4032, 4090], '4': [4042], 'III).': [4051, 4096, 4150, 4187, 4247, 4280], 'those': [4065, 4239], 'line': [4073], 'However': [4097], 'CT1': [4108, 4159], 'significantly': [4134], 'decreased': [4135], 'construct,': [4160], 'residue': [4172], 'reponsible': [4174], 'glutamate': [4190, 4198, 4221], 'alone': [4192], '(mutant': [4193, 4203], 'CT11)': [4194], 'valine': [4201], '395': [4202], 'CT12)': [4204], 'resulted': [4206], 'highlighting': [4216], 'crucial': [4218], '394.': [4222], 'notice': [4228], 'latter': [4232], 'control,': [4250], 'glutamine': [4254], '396': [4255], 'alone.': [4256], 'Q396A': [4258], 'clearly': [4261], 'CT2,': [4283], 'CT3,': [4284], 'CT4': [4286], 'exploring': [4287], 'parts': [4289], 'did': [4295], 'show': [4297], 'III).Table': [4304], 'IIIBinding': [4305], 'domainC-terminal': [4323], 'domainaBold': [4324], 'receptors.394-EVQAELRRKWRRWHLQ-409wt394-AAAAELRRKWRRWHLQ-409CT1394-EVQAAAAAKWRRWHLQ-409CT2394-EVQAELRRAAAAWHLQ-409CT3394-EVQAELRRKWRRAAAA-409CT4394-AVQAELRRKWRRWHLQ-409CT11394-AAQAELRRKWRRWHLQ-409CT12394-EVAAELRRKWRRWHLQ-409Q396AMutants125I-VIP': [4334], '"Ex': [4359]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054826751', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-16T12:22:27.259729', 'created_date': '2016-06-24'}
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