Specific Phosphorylation of Exogenous Protein and Peptide Substrates by the Human Cytomegalovirus UL97 Protein Kinase

Name: Work Video:
Duration: 3 min 30 s
Moon‐Chang Baek; Paula M. Krosky; Zuwen He; Donald M. Coen
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3468, 3936, 4104, 4115, 4343, 4447], 'whose': [17, 214], 'specificity': [18, 215, 438, 524, 824, 1211, 2722, 4230, 4995, 5006, 5064, 5489], 'for': [19, 45, 216, 242, 436, 442, 793, 825, 835, 854, 990, 1019, 1104, 1200, 1214, 1227, 1262, 1324, 1635, 1792, 1820, 1840, 1905, 1956, 2105, 2134, 2254, 2447, 2486, 2521, 2550, 2588, 2855, 3123, 3325, 3334, 3362, 3381, 3525, 3578, 3720, 3799, 4231, 4315, 5113, 5179, 5192, 5212, 5307, 5519, 5525, 5560, 5685, 5695, 5701, 5709, 5718, 5726, 5743], 'exogenous': [20, 169, 217, 366, 818, 1215, 1224, 2683, 4408, 4529, 4669, 4749, 5517], 'substrates': [22, 173, 219, 370, 820, 827, 1261, 1317, 2684, 2698, 3798, 4530, 4801, 5012, 5034, 5518, 5554, 5570], 'has': [23, 220, 775, 1112, 3989, 4515, 5626], 'remained': [24, 221, 829, 3040], 'unknown.': [25, 222, 830], 'We': [26, 223, 5028, 5690], 'found': [27, 224, 1788, 3333, 3916], 'purified,': [29, 226], 'recombinant': [30, 227], 'glutathioneS-transferase-UL97': [31, 228], 'fusion': [32, 229], 'histone': [36, 233, 1232, 1687, 1734, 2710, 2735, 2778, 2972, 4410, 4931], 'H2B.': [37, 107, 234, 304, 2941, 3140], 'Phosphorylation': [38, 88, 108, 235, 285, 305, 3984, 4099, 4359], 'was': [39, 119, 140, 236, 316, 337, 712, 740, 1268, 1444, 1511, 1519, 1531, 1563, 1584, 1590, 1602, 1620, 1643, 1651, 1675, 1771, 1776, 1781, 1875, 1885, 1903, 1980, 1988, 1996, 1999, 2008, 2087, 2099, 2103, 2114, 2139, 2232, 2235, 2262, 2312, 2356, 2411, 2445, 2484, 2514, 2530, 2624, 2750, 2798, 2820, 2915, 2945, 2950, 2990, 3003, 3018, 3114, 3171, 3216, 3224, 3254, 3312, 3344, 3358, 3368, 3414, 3423, 3834, 3857, 3869, 3924, 3933, 4095, 4107, 4118, 4176, 4364, 4425, 4653, 4989], 'abrogated': [40, 237], 'by': [41, 54, 113, 129, 238, 251, 310, 326, 1271, 1449, 1653, 1658, 1689, 1727, 1828, 1850, 1868, 1877, 1894, 1982, 1990, 2001, 2116, 2131, 2237, 2288, 2319, 2358, 2367, 2381, 2476, 2489, 2494, 2516, 2532, 2636, 2716, 3016, 3020, 3025, 3038, 3067, 3169, 3212, 3226, 3252, 3317, 3346, 3425, 3528, 3581, 3695, 3927, 3982, 3987, 4091, 4102, 4113, 4174, 4188, 4257, 4278, 4317, 4381, 4402, 4427, 4431, 4751, 4773, 4930, 4998, 5079, 5104, 5272, 5574, 5619], 'substitution': [42, 239, 2874, 3023, 5284], 'of': [43, 65, 69, 75, 80, 89, 109, 126, 138, 174, 188, 191, 240, 262, 266, 272, 277, 286, 306, 323, 335, 371, 385, 388, 425, 460, 533, 539, 628, 636, 648, 899, 1122, 1176, 1212, 1239, 1265, 1283, 1295, 1297, 1308, 1318, 1337, 1344, 1569, 1575, 1608, 1613, 1667, 1684, 1731, 1744, 1763, 1795, 1831, 1854, 1898, 1944, 2020, 2036, 2041, 2127, 2376, 2439, 2455, 2464, 2498, 2503, 2527, 2685, 2696, 2699, 2723, 2732, 2756, 2785, 2793, 2803, 2810, 2826, 2833, 2849, 2907, 2910, 2940, 2958, 2971, 2981, 3001, 3054, 3107, 3128, 3133, 3137, 3139, 3143, 3161, 3167, 3209, 3304, 3308, 3321, 3330, 3352, 3398, 3410, 3440, 3464, 3478, 3480, 3496, 3503, 3513, 3536, 3586, 3623, 3662, 3682, 3706, 3727, 3730, 3778, 3782, 3838, 3942, 3955, 3968, 3985, 4049, 4071, 4082, 4088, 4100, 4126, 4172, 4349, 4360, 4377, 4388, 4406, 4413, 4456, 4470, 4521, 4526, 4536, 4667, 4747, 4757, 4762, 4771, 4776, 4802, 4954, 4986, 4996, 5005, 5013, 5017, 5019, 5035, 5065, 5070, 5082, 5098, 5285, 5296, 5319, 5328, 5337, 5339, 5369, 5388, 5393, 5486, 5490, 5496, 5507, 5516, 5523, 5528, 5540, 5548, 5563, 5566, 5582, 5621, 5631, 5697, 5715, 5728], 'glutamine': [44, 241, 2831], 'a': [46, 55, 97, 243, 252, 294, 423, 634, 718, 779, 791, 1017, 1102, 1107, 1117, 1173, 1198, 1253, 1505, 1528, 1534, 1593, 1630, 1936, 1942, 2013, 2062, 2160, 2315, 2336, 2462, 2469, 2694, 2783, 2807, 2823, 2921, 2982, 3110, 3131, 3264, 3350, 3375, 3391, 3401, 3430, 3433, 3437, 3461, 3489, 3493, 3609, 3768, 3809, 3851, 3872, 3918, 4122, 4232, 4260, 4294, 4432, 4451, 4460, 4468, 4662, 5071, 5286, 5378, 5537, 5682, 5686], 'conserved': [47, 244], 'lysine': [48, 245, 2834, 2845], 'in': [49, 78, 106, 246, 275, 303, 626, 838, 857, 891, 972, 987, 1125, 1163, 1341, 1362, 1677, 1694, 1965, 1976, 2012, 2069, 2294, 2737, 2753, 2800, 2846, 2912, 2923, 2952, 2955, 2975, 2998, 3293, 3608, 3859, 4075, 4247, 4264, 4291, 4333, 4341, 4347, 4434, 4531, 4642, 4672, 4789, 4810, 4865, 4907, 5316, 5345, 5349, 5358, 5474, 5628], 'subdomain': [50, 247, 2847, 5381], 'II': [51, 248, 2848], 'and': [52, 61, 86, 118, 171, 184, 193, 249, 258, 283, 315, 368, 381, 390, 428, 453, 455, 457, 553, 748, 790, 841, 897, 967, 1100, 1119, 1162, 1183, 1203, 1217, 1234, 1274, 1286, 1315, 1327, 1378, 1418, 1446, 1473, 1571, 1582, 1599, 1610, 1633, 1672, 1707, 1723, 1741, 1779, 1806, 1826, 1845, 1870, 1872, 1890, 1948, 1950, 1978, 1992, 2010, 2022, 2039, 2101, 2151, 2166, 2243, 2264, 2286, 2299, 2354, 2370, 2506, 2524, 2580, 2634, 2639, 2657, 2687, 2707, 2709, 2758, 2774, 2780, 2872, 2919, 2964, 3009, 3014, 3024, 3031, 3070, 3180, 3218, 3315, 3338, 3349, 3360, 3394, 3457, 3509, 3628, 3639, 3652, 3687, 3699, 3704, 3732, 3742, 3791, 3795, 3973, 4047, 4084, 4093, 4206, 4225, 4249, 4286, 4335, 4412, 4459, 4765, 4787, 4897, 4956, 5007, 5032, 5055, 5059, 5200, 5361, 5373, 5580, 5704, 5733, 5740], 'inhibited': [53, 250], 'new': [56, 189, 253, 386, 1108, 1205, 1329, 1345, 3610, 3852, 5508, 5526], 'antiviral': [57, 254, 550, 844, 1020, 1109, 1206, 5509], 'drug,': [58, 255, 1110], 'maribavir.': [59, 256, 4464], 'Sequencing': [60, 257, 2410], 'mass': [62, 259, 418, 2378, 2519, 2522, 2637, 3434, 3490, 3510], 'spectrometric': [63, 260, 3511], 'analyses': [64, 261], 'purified32P-labeled': [66, 263], 'tryptic': [67, 264, 2155, 3534, 3584], 'peptides': [68, 91, 143, 265, 288, 340, 1267, 1298, 1749, 1855, 2121, 2148, 2156, 2244, 2291, 2332, 2630, 3260, 3276, 3766, 4185, 4253, 4324, 4363, 4380, 4415, 5322, 5622], 'H2B': [70, 267, 1688, 1735, 1882, 1902, 2007, 2154, 2736, 2749, 2775, 2788, 2795, 2911, 2949, 2973, 3036, 3065, 3097, 3108, 3168, 3210, 3215, 3244, 3247, 3447, 3532, 3537, 3587, 3731, 3779, 3986, 4050, 4248, 4334, 4438], 'revealed': [71, 268, 4197], 'the': [73, 110, 155, 181, 270, 307, 352, 378, 461, 531, 534, 549, 637, 903, 1210, 1237, 1293, 1302, 1309, 1342, 1355, 1516, 1600, 1662, 1668, 1673, 1755, 1829, 1864, 1873, 1899, 1994, 2018, 2029, 2065, 2300, 2323, 2385, 2404, 2420, 2481, 2499, 2525, 2541, 2545, 2577, 2584, 2628, 2721, 2730, 2754, 2767, 2786, 2801, 2843, 2908, 2924, 2930, 2956, 2968, 2987, 2995, 2999, 3021, 3105, 3126, 3150, 3159, 3165, 3206, 3219, 3232, 3242, 3305, 3353, 3420, 3441, 3446, 3454, 3465, 3470, 3481, 3497, 3520, 3550, 3572, 3600, 3630, 3633, 3641, 3644, 3660, 3683, 3691, 3707, 3721, 3724, 3733, 3739, 3752, 3757, 3783, 3841, 3956, 3964, 3976, 4069, 4080, 4086, 4179, 4183, 4201, 4209, 4221, 4244, 4250, 4265, 4269, 4304, 4307, 4327, 4336, 4354, 4386, 4389, 4392, 4400, 4435, 4444, 4471, 4645, 4668, 4725, 4737, 4742, 4766, 4808, 4952, 4994, 5003, 5063, 5080, 5092, 5099, 5109, 5196, 5205, 5213, 5265, 5280, 5329, 5335, 5389, 5481, 5487, 5505, 5546, 5557, 5561, 5629, 5713], 'sites': [74, 271, 1238, 1248, 3622, 3674, 3718, 3736, 3744, 4246, 4332, 4770, 5266], 'phosphorylation': [76, 105, 125, 139, 273, 302, 322, 336, 452, 1240, 1296, 1683, 1794, 2725, 2731, 2792, 2909, 2944, 3015, 3037, 3066, 3166, 3715, 3735, 3807, 3941, 3954, 3967, 4087, 4112, 4171, 4316, 4376, 4401, 4424, 4666, 4746, 4772, 4932, 4997, 5018, 5081, 5097, 5295], 'were,': [77, 274, 3419], 'order': [79, 276], 'extent,': [81, 278], 'Ser-38,': [82, 279, 3740, 4213], 'Ser-87,': [83, 280, 3741, 3932], 'Ser-6,': [84, 281], 'Ser-112,': [85, 282], 'Ser-124.': [87, 284], 'synthetic': [90, 287, 3919, 4323, 5297], 'containing': [92, 144, 289, 341, 1246, 1901, 2005, 2074, 2436, 3780, 3921, 3931, 4344], 'these': [93, 290, 1247, 1266, 2744, 2976, 3034, 3309, 3411, 3614, 4361, 4643], 'sites,': [94, 291, 3980], 'analyzed': [95, 292, 2366, 2635, 3424, 4187], 'using': [96, 293, 1252, 1420, 2428, 3542, 3592], 'new,': [98, 295, 1254], 'chimeric': [99, 296, 1255, 2538], 'gel': [100, 297, 1900, 1995, 2165, 2231, 2267, 2539, 2543, 2549, 2579, 3268, 3854, 3864, 3875, 3880], 'system,': [101, 298, 2540], 'correlated': [102, 299], 'with': [103, 142, 158, 300, 339, 355, 432, 449, 521, 1281, 1287, 1368, 1539, 1556, 1565, 1578, 1586, 1597, 1604, 1615, 1622, 1624, 1629, 1711, 1941, 1973, 2257, 2276, 2307, 2335, 2344, 2777, 2822, 3096, 3237, 3256, 3374, 3390, 3432, 3488, 3659, 3871, 3963, 4220, 4368, 4730, 4951, 5091, 5108, 5195, 5291, 5334, 5341, 5480, 5720], 'their': [104, 301, 4369], 'Ser-38': [111, 117, 308, 314, 3637, 3680, 3922, 3972], 'peptide': [112, 128, 172, 309, 325, 369, 1218, 1316, 2368, 2513, 3499, 3507, 3530, 3540, 3590, 3806, 3845, 3920, 3943, 4076, 4202, 4210, 5031, 5094, 5538, 5553, 5676, 5705], 'occurred': [115, 133, 312, 330, 5627], 'on': [116, 134, 180, 313, 331, 377, 746, 1193, 1301, 1513, 1647, 2314, 2413, 2655, 3178, 3549, 3599, 3950, 3966, 4204, 4212, 4271, 4385, 4416, 5042], 'specifically': [120, 317, 4203, 4211], 'sensitive': [121, 318, 4108, 4119, 4177], 'to': [122, 319, 716, 1026, 1115, 1190, 1241, 1289, 1503, 1533, 1789, 1952, 2033, 2143, 2304, 2341, 2398, 2403, 2408, 2468, 2472, 2765, 2842, 2917, 2992, 3057, 3176, 3269, 3364, 3436, 3460, 3492, 3677, 3776, 3804, 3844, 3910, 4109, 4120, 4178, 4716, 4734, 4744, 4768, 4807, 4859, 4902, 4990, 4993, 5001, 5008, 5045, 5102, 5216, 5366, 5534, 5577, 5584, 5623, 5731], 'maribavir,': [123, 320, 1111, 2929, 4110], 'whereas': [124, 321, 2576, 3327, 3697, 4111], 'this': [127, 161, 324, 358, 703, 1228, 2451, 2537, 2724, 2873, 3154, 3849, 3908, 4321, 4522, 4758, 4777, 4987, 5014, 5300, 5497, 5543], 'cAMP-dependent': [130, 327], 'Ser-36.': [135, 332], 'The': [136, 333, 664, 772, 1523, 1561, 1640, 1813, 1836, 1859, 1896, 2003, 2084, 2120, 2146, 2229, 2260, 2266, 2281, 2331, 2361, 3141, 3258, 3427, 3475, 3583, 3672, 3712, 3801, 4301, 4395, 4486, 5096, 5325, 5514, 5675], 'extent': [137, 334, 1294], 'greatest': [141, 338], 'Arg': [146, 343, 4263, 4350, 5276, 5288], 'or': [147, 344, 1388, 1765, 2796, 3146, 3416, 3772, 4262, 4351, 4437, 4661, 5277, 5289], 'Lys': [148, 345, 4261, 4352, 5278, 5290], 'residue': [149, 346, 1303, 2448, 2487, 2836, 3367, 3403, 3770, 4296, 4390, 5303], '5': [150, 347, 1305, 1712, 1777, 2170, 3759], 'positions': [151, 348, 1306, 3750, 5202, 5318], 'downstream': [152, 349, 1307, 3761], '(P+5)': [153, 350], 'from': [154, 351, 902, 977, 1354, 1459, 1466, 1527, 1892, 2339, 3273, 3355, 3445, 3505, 3519, 3531, 3539, 3571, 3589, 3865, 3876, 3913, 4326, 4780, 5052, 5068, 5185], 'Ser.': [156, 353], 'Substitution': [157, 354], 'Ala': [159, 356, 4346, 5292], 'at': [160, 357, 985, 1661, 1679, 1716, 1817, 1959, 2090, 2169, 2251, 2273, 2322, 2384, 2419, 2835, 3100, 3120, 3404, 3554, 3604, 3716, 3748, 3756, 4297, 4353, 4391, 5279], 'position': [162, 359, 3405, 3758, 4311, 5215, 5331], 'essentially': [163, 360, 4365, 5293], 'eliminated': [164, 361, 2938, 3004, 3019, 4665], 'activity.': [165, 362, 2985], 'These': [166, 363, 1784, 2902, 3655, 4946], 'results': [167, 364, 1312, 2903, 3615, 3656, 3661, 4302, 5261, 5502, 5729], 'identify': [168, 365, 1313, 3205, 3241, 3365, 3616], 'UL97,': [175, 372, 1690, 3696, 4085, 4103, 4117, 4752, 4999, 5541], 'reveal': [176, 373, 1328], 'dependence': [179, 376], 'P+5': [182, 379, 4266, 4298, 4310, 4355, 4393, 5214, 5281, 5287, 5330, 5482], 'position,': [183, 380, 4356], 'may': [185, 382, 5503, 5679], 'abet': [186, 383, 1322], 'discovery': [187, 384, 1343, 5506], 'inhibitors': [190, 387, 1326, 5527, 5565], 'human': [194, 391, 394, 540, 1164], 'replication.': [196, 393], 'cyclic': [396, 1275], 'AMP-dependent': [397, 1276], 'glutathione': [400, 1391], 'S-transferase': [401, 1392], 'elution': [402, 1540], 'buffer': [403, 1541, 1785, 2582, 2954], 'p-tosyl-l-phenylalanine': [404], 'chloromethyl': [405], 'ketone': [406], 'high': [407, 781, 785, 5057, 5549], 'performance': [408], 'liquid': [409, 1878, 2042, 2477], 'chromatography': [410], 'reverse': [411], 'phase-HPLC': [412], 'matrix-assisted': [413, 2371], 'laser': [414, 2372, 2517], 'desorption': [415, 2373, 2518], 'ionization': [416, 2374], 'time-of-flight': [417], 'spectrometry': [419, 2379, 2520, 2638], 'Protein': [420, 665, 1649, 4487], 'kinases': [421, 1847, 2851, 5022, 5088, 5344, 5395], 'regulate': [422], 'multitude': [424], 'biological': [426], 'processes': [427, 4925], 'accordingly': [429], 'act': [431], 'exquisite': [433], 'specificity.': [434], 'Mechanisms': [435], 'ensuring': [437], 'include': [439], 'modules': [441], 'binding': [443, 5368, 5391], 'specific': [444, 450, 1174, 1242, 3243, 4123, 4417, 4461, 4663, 5183], 'substrates,': [445, 1219, 1515], 'regulation': [446], 'via': [447, 1023], 'interactions': [448], 'ligands,': [451], 'dephosphorylation,': [454], 'sequence': [456, 3448, 5050], 'structural': [458], 'determinants': [459], 'active': [462, 1512], 'site': [463, 4270, 4340, 5392], '(1Taylor': [464], 'S.S.': [465, 912, 1135], 'Radzio-Andzelm': [466], 'E.': [467, 556, 1034, 4026, 4052, 4820, 5162], 'Hunter': [468, 2860, 5245, 5414, 5452], 'T.': [469, 2558, 2861, 4567, 4575, 4826, 4934, 5246, 5415, 5453, 5741], 'FASEB': [470, 2862, 5416], 'J.': [471, 679, 682, 694, 727, 764, 808, 876, 1408, 1494, 1926, 2199, 2554, 2673, 2863, 2891, 3087, 3196, 3997, 4013, 4031, 4057, 4136, 4155, 4158, 4503, 4542, 4545, 4595, 4611, 4624, 4626, 4631, 4683, 4696, 4698, 4703, 4827, 4839, 4976, 5165, 5244, 5402, 5417, 5451, 5594, 5652, 5699], '1995;': [472, 2864, 5418], '9:': [473, 2865, 5419], '1255-1266Crossref': [474], 'PubMed': [475, 495, 513, 565, 586, 619, 687, 699, 733, 769, 813, 881, 956, 1010, 1043, 1064, 1097, 1413, 1499, 1931, 2056, 2210, 2678, 2867, 2896, 3092, 3201, 3825, 4006, 4022, 4040, 4066, 4145, 4167, 4509, 4550, 4561, 4586, 4600, 4616, 4636, 4688, 4708, 4832, 4850, 4941, 4981, 5138, 5152, 5174, 5255, 5408, 5421, 5462, 5613, 5670], 'Scopus': [476, 496, 514, 566, 587, 734, 957, 1011, 1044, 1065, 2057, 2211, 2225, 2613, 2868, 3287, 3826, 3903, 4510, 4562, 4587, 4617, 4637, 4689, 4709, 4851, 4942, 5139, 5153, 5256, 5409, 5422, 5463, 5614, 5671], '(159)': [477], 'Google': [478, 498, 516, 568, 589, 620, 688, 700, 736, 770, 814, 882, 959, 1013, 1046, 1067, 1098, 1414, 1500, 1932, 2059, 2185, 2213, 2227, 2601, 2615, 2679, 2870, 2897, 3093, 3202, 3289, 3828, 3891, 3905, 4007, 4023, 4041, 4067, 4146, 4168, 4512, 4551, 4564, 4589, 4601, 4619, 4639, 4691, 4711, 4833, 4853, 4944, 4982, 5141, 5155, 5175, 5258, 5411, 5424, 5465, 5616, 5673], 'Scholar,': [479, 499, 569, 590, 674, 689, 1047, 1068, 2186, 2214, 2602, 3892, 4008, 4024, 4147, 4496, 4552, 4565, 4590, 4602, 4620, 4692, 4834, 5142, 5156, 5425], '2Johnson': [480], 'L.N.': [481, 501], 'Noble': [482, 504], 'M.E.M.': [483, 505], 'Owen': [484, 506], 'D.J.': [485, 507, 655, 4477, 5160, 5238, 5445], 'Cell.': [486, 5250, 5457, 5604], '1996;': [487, 2053, 4829, 5252, 5459], '85:': [488], '149-158Abstract': [489], 'Full': [490, 492, 2205, 2207, 4003, 4019, 4037, 4063, 4142, 4164, 5133, 5135, 5171, 5608, 5610], 'Text': [491, 493, 2206, 2208, 4004, 4020, 4038, 4064, 4143, 4165, 5134, 5136, 5172, 5609, 5611], 'PDF': [494, 2209, 4005, 4021, 4039, 4065, 4144, 4166, 5137, 5173, 5612], '(1178)': [497], '3Johnson': [500], 'Lowe': [502], 'E.D.': [503], 'FEBS': [508], 'Lett.': [509], '1998;': [510], '430:': [511], '1-11Crossref': [512], '(184)': [515], 'Scholar).': [517, 621, 701, 737, 771, 815, 883, 960, 1014, 1437, 1501, 2060, 2228, 2680, 3203, 3290, 3829, 3906, 4042, 4169, 4513, 4640, 4854, 4945, 4983, 5176, 5259, 5466, 5674], 'A': [518, 974, 2561, 4984], 'substrate': [523, 1226, 1334, 2690, 4750, 5112, 5193, 5350, 5488, 5539], 'UL97.': [526, 1263, 3800, 4318, 4803, 5308, 5513, 5529], 'This': [527, 1588, 2137, 2942, 3960], 'enzyme,': [528, 1229], 'which': [529, 1338, 3366, 3386, 3399, 3409, 3860, 4072, 5383], 'product': [532], 'open': [536], 'reading': [537], 'frame': [538], '(HCMV),1': [542], 'analogues': [546], 'drugs': [551, 5510, 5634], 'acyclovir': [552], '(4Littler': [555, 1033], 'Stuart': [557, 1035], 'A.D.': [558, 1036], 'Chee': [559, 1037], 'M.S.': [560, 722, 1038, 4498, 5397], 'Nature.': [561, 582, 1039, 1060], '1992;': [562, 583, 684, 1040, 1061, 4547, 4558], '358:': [563, 584, 1041, 1062], '160-162Crossref': [564, 1042], '(345)': [567, 1045], '5Sullivan': [570, 1048], 'V.': [571, 1049], 'Talarico': [572, 917, 1050, 1140], 'C.L.': [573, 592, 918, 1051, 1070, 1141], 'Stanat': [574, 601, 923, 1052, 1079, 1146], 'S.C.': [575, 910, 924, 1053, 1133, 1147], 'Davis': [576, 599, 915, 1054, 1077, 1138], 'M.': [577, 962, 964, 969, 1055, 1801, 1808, 2046, 2050, 4028, 4054, 4284, 4288, 4824, 4837, 5736], 'Coen': [578, 607, 762, 806, 870, 1056, 1085, 1406, 1492, 1924, 2671, 2889, 3085, 3194, 4970], 'D.M.': [579, 608, 763, 807, 871, 1057, 1086, 1407, 1493, 1925, 2672, 2890, 3086, 3195, 4872, 4971], 'Biron': [580, 611, 760, 804, 1058, 1089, 1404, 1490, 1922, 2669, 2887, 3083, 3192, 5725], 'K.K.': [581, 612, 761, 805, 906, 1059, 1090, 1129, 1405, 1491, 1923, 2670, 2888, 3084, 3193], '162-164Crossref': [585, 1063], '(385)': [588, 1066], '6Talarico': [591, 1069], 'Burnette': [593, 1071], 'T.C.': [594, 1072], 'Miller': [595, 1073], 'W.H.': [596, 1074], 'Smith': [597, 692, 913, 1075, 1136], 'S.L.': [598, 1076], 'M.G.': [600, 916, 1078, 1139], 'S.C.,': [602, 1080], 'Ng,': [603, 1081], 'T.I.,': [604, 1082], 'He,': [605, 752, 796, 1083, 1396, 1482, 1805, 1914, 2661, 2879, 3075, 3184], 'Z.': [606, 1084, 1803, 5117, 5596], 'Roizman': [609, 998, 1087, 4881], 'B.': [610, 999, 1088, 1382, 4882, 4910], 'Antimicrob.': [613, 931, 1091, 1154], 'Agents': [614, 932, 1092, 1155], 'Chemother.': [615, 933, 1093, 1156], '1999;': [616, 878, 1094, 2202, 4597, 4978], '43:': [617, 1095], '1941-1946Crossref': [618, 1096], 'also': [624, 833, 1440, 2761, 2946, 3934, 3946, 4448], 'terms': [627], 'its': [629, 817, 823, 836, 1024, 1185, 1191, 1332, 2689, 5043, 5049, 5056], 'primary': [630], 'sequence.': [631], 'It': [632, 4514, 4791, 5530], 'member': [635, 4469, 4756, 4775], 'HvUL': [638, 4472, 5020], 'family,': [641, 704], 'which,': [642], 'although': [643], 'sharing': [644], 'many': [645], 'motifs': [646], 'typical': [647], 'kinases,': [650, 4764, 5054, 5182], 'relatively': [652, 3713], 'divergent': [653, 4755, 4760], '(7McGeoch': [654, 4476], 'Coulter': [656, 4478], 'L.J.': [657, 4479], 'Moss': [658, 4480], 'H.W.M.': [659, 4481], 'Hardie': [660, 4482], 'G.': [661, 867, 4483, 4967], 'Hanks': [662, 4484], 'S.': [663, 865, 951, 1005, 1426, 4485, 4569, 4573, 4965, 5119, 5590, 5664], 'Kinase': [666, 4488], 'Facts': [667, 4489], 'Book.': [668, 4490], '1.': [669, 4491], 'Academic': [670, 4492], 'Press,': [671, 4493], 'London1995:': [672, 4494], '391-393Google': [673, 4495], '8de': [675], 'Wind': [676, 4539], 'N.': [677, 863, 4540, 4963, 5121], 'Domen': [678, 4541], 'Berns': [680, 4543], 'A.': [681, 952, 1006, 2044, 4544, 4592, 4818, 5654, 5707], 'Virol.': [683, 695, 729, 765, 809, 877, 1409, 1495, 1927, 2674, 2892, 3088, 3197, 4505, 4546, 4596, 4612, 4632, 4684, 4704, 4828, 4977, 5404], '66:': [685, 4548], '5200-5209Crossref': [686, 4549], '9Smith': [690], 'R.F.': [691], 'T.F.': [693], '1989;': [696, 730, 4161, 4506, 5405], '63:': [697], '450-455Crossref': [698], 'Within': [702], 'diverges': [706], 'even': [707], 'further,': [708, 2726], 'so': [709], 'it': [711, 739, 1998, 4652, 5208, 5374], 'not': [713, 848, 1811, 2920, 3063, 3157, 3453, 3469, 3937, 4105, 4116, 4441, 4648, 4654, 4793, 5024, 5376], 'immediately': [714], 'assumed': [715], 'be': [717, 1116, 1790, 3947, 4313, 4798, 4928, 4949, 5217, 5556, 5572], '(10Chee': [721, 5396], 'Lawrence': [723, 4499, 5398], 'G.L.': [724, 4500, 5399], 'Barrell': [725, 4501, 5400], 'B.G.': [726, 4502, 5401], 'Gen.': [728, 4504, 5403], '70:': [731, 4507, 4830, 5406], '1151-1160Crossref': [732, 4508, 5407], '(150)': [735, 958, 4511, 5410], 'Subsequently,': [738, 1502], 'shown': [741, 1114, 3292, 4655], 'autophosphorylate': [745, 3177], 'serines': [747, 1285, 3179, 3786, 5583], 'threonines': [749, 3181], '(11He': [750, 1394, 1480, 1912, 2659, 2877, 3073, 3182], 'Z.,': [751, 795, 1395, 1481, 1913, 2660, 2878, 3074, 3183, 5220, 5427], 'Y.-S.': [753, 797, 1397, 1483, 1915, 2662, 2880, 3076, 3185], 'Kim': [754, 798, 1398, 1484, 1916, 2663, 2881, 3077, 3186], 'Y.': [755, 799, 1399, 1485, 1917, 2190, 2192, 2664, 2882, 3078, 3187, 4030, 4056, 4579, 4581], 'Chu': [756, 800, 1400, 1486, 1918, 2665, 2883, 3079, 3188], 'L.': [757, 801, 1401, 1487, 1919, 2666, 2884, 3080, 3189, 4153, 4843, 5716, 5734], 'Ohmstede': [758, 802, 1402, 1488, 1920, 2667, 2885, 3081, 3190], 'C.': [759, 803, 965, 1403, 1489, 1798, 1921, 2668, 2886, 3082, 3191, 4281, 4556, 4630, 4702, 5230, 5236, 5437, 5443, 5693], '1997;': [766, 810, 1410, 1496, 1928, 2675, 2893, 3089, 3198, 4583, 4847], '71:': [767, 811, 1411, 1497, 1929, 2676, 2894, 3090, 3199], '405-411Crossref': [768, 812, 1412, 1498, 1930, 2677, 2895, 3091, 3200], 'autophosphorylation': [773, 2876, 3072, 3837], 'activity': [774, 1180, 1187, 1509, 2857], 'uncommon': [776], 'features': [777], 'including': [778, 4533], 'rather': [780, 4308, 4429, 5301], 'optimal': [782, 786, 1791], 'pH': [783, 1546, 1960, 2305, 5058], '(9.5),': [784], 'NaCl': [787, 1559, 2988, 5060], '(1.5': [788], 'm),': [789], 'preference': [792], 'Mn2+(11He': [794], 'However,': [816, 2927, 3830, 4641], 'and,': [821, 1251, 3949], 'accordingly,': [822], 'have': [828, 2583, 4228, 5023, 5038, 5377, 5535], 'interesting': [834], 'role': [837], 'viral': [839, 892, 991], 'infection': [840, 4856], 'drug': [845], 'target.': [846], 'Although': [847], 'absolutely': [849], 'essential,': [850], 'critical': [853], 'HCMV': [855, 1123, 2646, 4404, 4465, 4855], 'replication': [856, 1124], 'cell': [858, 1126], 'culture': [859, 1127], '(12Prichard': [860, 4960], 'M.N.': [861, 943, 4961], 'Gao': [862, 4962], 'Jairath': [864, 4964], 'Mulamba': [866, 4966], 'Krosky': [868, 4968], 'P.': [869, 1800, 4283, 4969], 'Parker': [872, 4972], 'B.O.': [873, 4973], 'Pari': [874, 4974], 'G.S.': [875, 4975], '73:': [879, 4598, 4979], '5663-5670Crossref': [880, 4980], 'There': [884], 'evidence': [886], 'plays': [889], 'roles': [890], 'DNA': [893], 'synthesis,': [894], 'virus': [895], 'assembly,': [896], 'egress': [898], 'assembled': [900], 'nucleocapsids': [901], 'nucleus': [904, 4809], '(13Biron': [905, 1128], 'Harvey': [907, 1130], 'R.J.': [908, 1131], 'Chamberlain': [909, 1132], 'Good': [911, 1134], 'A.A.': [914, 1137], 'Ferris': [919, 1142], 'R.': [920, 1143, 1424], 'Dornsife': [921, 1144], 'R.E.': [922, 1145], 'Drach': [925, 1148], 'J.C.': [926, 1149, 5644], 'Townsend': [927, 1150], 'L.B.': [928, 1151], 'Koszalka': [929, 1152], 'G.W.': [930, 1153], '2002;': [934, 1157], '45': [935, 1158], '(in': [936, 1159], 'press)Google': [937, 1160], 'Scholar,14Wolf': [938], 'D.G.': [939], 'Courcelle': [940, 4869], 'C.T.': [941, 4870], 'Prichard': [942], 'Mocarski': [944], 'E.S.': [945, 4868], 'Proc.': [946, 1000], 'Natl.': [947, 1001], 'Acad.': [948, 1002], 'Sci.': [949, 1003], 'U.': [950, 1004], '2001;': [953, 4633, 4705, 4938], '98:': [954], '1895-1900Crossref': [955], '2P.': [961], 'Krosky,': [963, 1802, 4285, 5739], 'Baek,': [966, 1799, 4282], 'D.': [968, 1807, 4287, 4814, 4912, 5640, 5738], 'Coen,': [970, 1809, 4289], 'manuscript': [971, 4290], 'preparation.': [973, 2926], 'homologous': [975], 'another': [978], 'herpesvirus,': [979], 'herpes': [980], 'simplex': [981], 'virus,': [982], 'important,': [984], 'least': [986], 'certain': [988, 1514, 3717, 4519, 4534], 'cells,': [989], 'gene': [992, 4862], 'expression': [993, 4863], '(15Purves': [994], 'F.C.': [995], 'Ogle': [996], 'W.O.': [997], '1993;': [1007, 2182, 2598, 3888], '90:': [1008], '6701-6705Crossref': [1009], '(196)': [1012], 'target': [1018, 1103, 1199, 5512], 'drugs,': [1021], 'both': [1022, 1201, 1272, 1336, 2934, 3397, 3418, 4045, 4450, 4924, 5000, 5087], 'ability': [1025, 5044], 'activate': [1027], 'Scholar)': [1099, 1161, 1415, 2616, 2898], 'inhibition.': [1105], 'Recently,': [1106], 'been': [1113, 3250, 3990, 4516, 5026], 'potent': [1118], 'selective': [1120, 2808], 'inhibitor': [1121, 1175, 2809, 4125, 4239, 4664, 5633], 'subjects.': [1165], '3K.': [1166], 'K.': [1167, 4822, 5588, 5724], 'Biron,': [1168], 'personal': [1169], 'communication.': [1170], 'Maribavir': [1171, 1438], '(this': [1181], 'report),3': [1182], 'indeed': [1184], 'anti-HCMV': [1186, 1346], 'due': [1189, 2764, 2916, 3843], 'effects': [1192], 'UL972,3.': [1194], 'Thus,': [1195, 4218, 4375, 5299], 'established': [1202, 5110], 'promising': [1204], 'compounds.': [1207], 'To': [1208, 2016, 2681, 2719, 3103, 3204, 3240, 3407, 3847, 4078, 4319, 4420], 'investigate': [1209, 2720], 'we': [1220, 2692, 2727, 3915, 4440], 'first': [1221, 4743, 4767], 'identified': [1222, 5536], 'calf': [1230, 1685, 1732, 2733], 'thymus': [1231, 1686, 1733, 2734], 'H2B,': [1233, 2706, 3970, 4411, 4781], 'then': [1235], 'mapped': [1236], 'serine': [1243, 2656, 3402, 3619, 3754, 4234], 'residues.': [1244, 4419], 'Peptides': [1245, 2491, 3774], 'were': [1249, 1258, 1360, 1416, 1457, 1464, 1475, 1692, 1752, 1767, 1787, 1815, 1838, 1848, 1862, 1866, 1971, 2031, 2067, 2122, 2149, 2157, 2241, 2245, 2269, 2284, 2292, 2302, 2333, 2349, 2365, 2396, 2492, 2631, 2712, 3098, 3261, 3296, 3323, 3332, 3379, 3675, 3690, 3793, 3975, 4186, 4193, 4357, 4647, 4728, 5312], 'synthesized': [1250, 1445, 2493, 3794], 'electrophoresis': [1256, 1953, 3855], 'technique,': [1257], 'assayed': [1259], 'One': [1264], 'phosphorylated': [1269, 1753, 2006, 2085, 2456, 2715, 3211, 3251, 3271, 3369, 3377, 3415, 3753, 3785, 3926, 3979, 4184, 4200, 4208, 4256, 4331, 5271, 5321], 'extensively': [1270, 3991, 4255, 4276, 4330, 4338, 4446, 4650, 5270, 5320], '(PKA)': [1279], 'utilization': [1282], 'different': [1284, 1290, 3618, 4379, 5083], 'susceptibility': [1288], 'inhibitors.': [1291], 'Remarkably,': [1292], 'depended': [1299], 'critically': [1300, 4383], 'lying': [1304], 'serine.': [1310], 'Our': [1311, 5260, 5501], 'could': [1321, 1339, 3945, 4797], 'assays': [1323, 1691, 5524], 'novel': [1325, 5687], 'information': [1330], 'regarding': [1331], 'specificity,': [1335, 2691, 5194], 'aid': [1340, 4953, 5504], 'drugs.': [1347], 'Spodoptera': [1348], 'frugiperda': [1349], '9': [1350], 'cells': [1351, 4812], '(Sf9),': [1352], 'obtained': [1353, 3380], 'American': [1356], 'Type': [1357], 'Culture': [1358], 'Collection,': [1359], 'maintained': [1361, 1419], "Grace's": [1363], 'insect': [1364], 'medium': [1365], '(Invitrogen)': [1366], 'supplemented': [1367], '10%': [1369, 1554, 2308], 'fetal': [1370], 'bovine': [1371], 'serum': [1372], '(Atlanta': [1373], 'Biologicals),': [1374], '100': [1375, 1379, 1708, 2070], 'units/ml': [1376], 'penicillin,': [1377], 'μg/ml': [1380], 'streptomycin': [1381], 'Recombinant': [1383], 'baculoviruses': [1384], 'expressing': [1385], 'wild': [1386, 4370], 'type': [1387, 4371], 'mutant': [1389, 2824, 4362, 4454, 4713], 'K355Q': [1390, 2931, 3022, 4180, 4718], '(GST)-UL97': [1393], 'propagated': [1417], 'standard': [1421, 2429, 2546, 3802, 3866], 'methods': [1422], '(16Crossen': [1423], 'Gruenwald': [1425], 'Baculovirus': [1427], 'Expression': [1428], 'Vector': [1429], 'System': [1430], 'Manual.': [1431, 2563], '5th': [1432], 'Ed.': [1433, 2565, 4889], 'Pharmingen,': [1434], 'San': [1435], 'Diego1998Google': [1436], '(5,6-dichloro-2-(isopropylamino)-1-β-l-ribofuranosyl-1H-benzimidazole,': [1439], 'known': [1441, 3175, 4858, 4901, 5471], '1263W94)': [1443], 'kindly': [1447], 'provided': [1448], 'GlaxoSmithKline.': [1450], 'Unless': [1451], 'otherwise': [1452, 1721, 1824], 'noted,': [1453], 'all': [1454, 3231, 3382, 3749, 3764], 'other': [1455, 2023, 3482, 3957, 4731, 4898, 5317, 5342, 5394], 'chemicals': [1456], 'purchased': [1458, 1465], 'Sigma.': [1460], 'All': [1461], 'column': [1462, 1530, 1567, 1573, 1595, 1601, 1606, 2317], 'materials': [1463], 'AmershamBiosciences.': [1467], 'For': [1468, 1682, 2393], 'initial': [1469], 'studies,': [1470], 'baculovirus-expressed': [1471], 'GST-UL97': [1472, 1619, 1764, 1793, 1893, 2759, 2773, 2797, 2827, 2918, 2959, 3002, 3017, 3039, 3068, 3253, 3928, 4092], 'GST-UL97K355Q': [1474], 'purified': [1476, 2717, 3316, 4403, 4443, 4649], 'detailed': [1478], 'previously': [1479, 1537, 1910, 2174, 5025], 'eliminate': [1504, 3064], 'contaminating': [1506, 2983], 'previous': [1517], 'protocol': [1518, 3803], 'modified': [1520], 'follows.': [1522], 'eluted': [1526, 1585, 1621, 2334], 'glutathione-Sepharose': [1529], 'bound': [1532], 'Q-Sepharose': [1535, 1562], 'column,': [1536], 'equilibrated': [1538], '(EB;': [1542], '50': [1543, 1557, 1695, 2075], 'mm': [1544, 1549, 1552, 1558, 1580, 1700, 1705, 2071, 2741], 'Tris,': [1545], '8.0,': [1547], '2': [1548, 1551, 1636, 1704, 3135, 3725], 'dithiothreitol,': [1550, 1706], 'EDTA,': [1553], 'glycerol)': [1555], '(EB-50).': [1560], 'washed': [1564, 1603], '30': [1566, 1572, 1605, 1957, 2352], 'volumes': [1568, 1574, 1607, 1612], 'EB-50': [1570], 'EB-150': [1576], '(EB': [1577], '150': [1579], 'NaCl),': [1581], 'EB-500.': [1587], 'material': [1589], 'loaded': [1591, 2158], 'onto': [1592, 1935, 2159], 'phenyl-Sepharose': [1594], '(equilibrated': [1596], 'EB-1000),': [1598], 'EB-500': [1609], '10': [1611, 1702, 3703], 'EB-300': [1614], '0.1%': [1616, 1625, 2248, 2278, 2295, 2345], 'Triton': [1617, 1626], 'X-100.': [1618], 'EB-0': [1623], 'X-100,': [1627], 'concentrated': [1628], 'Centricon-30': [1631], 'concentrator,': [1632], 'dialyzed': [1634], 'h': [1637, 2256], 'against': [1638], 'EB-50.': [1639], 'resulting': [1641, 1860, 2230, 3220, 3259], 'apparently': [1644], 'homogeneous': [1645], 'based': [1646, 5041], 'SDS-PAGE.': [1648, 1852, 1895], 'concentration': [1650, 1770, 1775, 2526, 2989], 'determined': [1652, 3527, 3580], 'amino': [1654, 1728, 2533, 2640, 3207, 3221, 3234, 5710], 'acid': [1655, 1729, 1907, 1969, 2129, 2250, 2534, 2641, 3222, 3664, 5711, 5722], 'analysis': [1656, 1908, 3512, 3665, 4196], 'performed': [1657, 1693, 2313, 2412, 3099, 3115, 4426], 'Angelo': [1659], 'Dickerson': [1660, 5708], 'Molecular': [1663, 1737, 2082, 2324, 2386, 2421, 2507, 2559], 'Biology': [1664, 2325, 2387, 2422], 'Core': [1665, 2326, 2388, 2423], 'Facility': [1666, 2424, 2501], 'Dana-Farber': [1669, 2328, 2390], 'Cancer': [1670, 2329, 2391, 2426], 'Institute,': [1671], 'stored': [1676], 'aliquots': [1678], '−80': [1680], '°C.': [1681, 2092], 'mmTris-HCl': [1696], '(pH': [1697], '9.0),': [1698], '300': [1699, 1761, 2993, 3101], 'NaCl,': [1701, 3055], 'mmMgCl2,': [1703], 'μm': [1709], 'ATP),': [1710], 'μCi/sample': [1713], '[γ-32P]': [1714], 'ATP': [1715, 3145], '>5000': [1717], 'Ci/mmol': [1718], '(ICN),': [1719], 'unless': [1720, 1823], 'specified,': [1722, 1825], 'various': [1724, 4528], 'concentrations': [1725, 2019, 3053], '(determined': [1726], 'analysis)': [1730], '(Roche': [1736], 'Biochemicals;': [1738], '"electrophoretically': [1739], 'homogeneous")': [1740], 'selected': [1742], 'amounts': [1743, 2980], 'GST-UL97,': [1745, 3213], 'specified.': [1747], 'Synthetic': [1748], '(200': [1750], 'μm)': [1751], 'under': [1754, 2118], 'same': [1756, 2585, 4222, 5093], 'conditions': [1757, 1786, 2745], 'except': [1758, 2431, 2617, 3384, 3755], 'either': [1760, 2794], 'ng': [1762], 'PKA': [1766, 3988, 4043, 4083, 4094, 4127, 4199, 4226, 5105], 'used,': [1768], 'MgCl2': [1769], '20': [1772, 2135], 'mm,': [1773, 1778, 2994], 'dithiothreitol': [1774], 'there': [1780, 3295, 5311], 'no': [1782, 5313], 'NaCl.': [1783], 'peptides.': [1796, 3959, 5298], '4M.': [1797], 'W.': [1804, 4628, 4700], 'data': [1810, 3372, 3388, 3965], 'shown.': [1812], 'reactions': [1814], 'incubated': [1816, 2951], '37': [1818, 2091, 3121], '°C': [1819, 2253, 2275, 3122], '1': [1821, 2963, 3058, 3124], 'h,': [1822, 3125], 'terminated': [1827], 'addition': [1830, 3142], '6×': [1832], 'SDS': [1833, 2021], 'sample': [1834], 'buffer.': [1835], 'samples': [1837], 'boiled': [1839], '3': [1841, 2255, 3030], 'min.': [1842, 2136], 'Radiolabeled': [1843], 'histones': [1844, 2704, 4537, 4785, 4796], 'separated': [1849, 1891, 3225], '15%': [1851], 'PAGE': [1853, 2590], 'described': [1857, 1888, 1911, 2173, 2644, 4397], 'below.': [1858], 'gels': [1861], 'dried,': [1863, 1997, 2233], 'bands': [1865, 2240], 'visualized': [1867, 1972], 'autoradiography': [1869], 'excised,': [1871, 2242, 2632, 3313], 'radioactivity': [1874, 1979, 2234, 2355, 3322, 3331], 'quantified': [1876, 2531], 'scintillation': [1879, 2478], 'counting.': [1880, 2360], 'Histone': [1881], '(50': [1883], 'μg)': [1884, 2098], 'phosphorylated,': [1886, 3935], 'above,': [1889, 4243], 'portion': [1897, 2463, 2483, 3351], 'prepared': [1904], 'phosphoamino': [1906, 3663, 5721], 'Scholar);': [1933], 'spotted': [1934], 'cellulose': [1937], 'thin': [1938, 3227], 'layer': [1939, 3228], 'plate': [1940], 'mixture': [1943, 3223], 'unlabeled': [1945], 'phosphoserine,': [1946], 'phosphothreonine,': [1947], 'phosphotyrosine;': [1949], 'subjected': [1951, 2032], '(1200': [1954], 'V': [1955, 5360], 'min)': [1958], '3.0': [1961], '(acetic': [1962], 'acid/pyridine/water,': [1963], '75:5:920)': [1964], 'one': [1966, 3458, 3486], 'dimension.': [1967], 'Phosphoamino': [1968], 'standards': [1970], '0.2%': [1974], 'ninhydrin': [1975], 'acetone,': [1977], 'detected': [1981, 2000, 2236, 3324], 'autoradiography.': [1983, 2002], 'Phosphorylated': [1984], '32P-H2B': [1985], '(1': [1986], 'mg)': [1987], 'resolved': [1989, 3262], 'SDS-PAGE,': [1991], 'after': [1993, 3149], 'band': [2004, 3508], 'excised': [2009], 'placed': [2011], 'microcentrifuge': [2014], 'tube.': [2015], 'reduce': [2017], 'contaminants': [2024], 'inhibit': [2027], 'trypsin,': [2028], 'slices': [2030, 2066, 2268], 'two': [2034, 2282, 3412, 3958, 4251, 4328, 4673], 'cycles': [2035], 'dehydration,': [2037, 2064], 'rehydration,': [2038], 'removal': [2040], '(17Shevchenko': [2043], 'Wilm': [2045], 'Vorm': [2047], 'O.': [2048, 5228, 5435], 'Mann': [2049], 'Anal.': [2051, 3820], 'Chem.': [2052, 2201, 3999, 4015, 4033, 4059, 4138, 4160, 5167], '68:': [2054], '850-858Crossref': [2055], '(7822)': [2058], 'Following': [2061], 'third': [2063], 'suspended': [2068], 'ammonium': [2072, 2112], 'bicarbonate': [2073, 2113], 'μg': [2076], 'TPCK-treated': [2077], 'trypsin': [2078, 2096], '(sequencing': [2079], 'grade;': [2080], 'Roche': [2081], 'Biochemicals).': [2083], 'digested': [2088, 3255], 'overnight': [2089, 2168, 2272], 'More': [2093, 5177], 'TPCK-': [2094], 'treated': [2095], '(25': [2097], 'added,': [2100], 'incubation': [2102, 3119], 'continued': [2104], 'additional': [2107], '6': [2108], 'h.': [2109], 'Then': [2110], 'excess': [2111], 'removed': [2115, 2263], 'evaporation': [2117], 'vacuum.': [2119], 'extracted': [2123, 2147, 2246, 2271], 'into': [2124, 2247], '400': [2125], 'μl': [2126], 'acetonitrile/formic': [2128], '(1:1)': [2130], 'intermittently': [2132], 'vortexing': [2133], 'step': [2138], 'repeated': [2140], 'three': [2141, 3328, 3692, 3765, 4245, 4378], 'times': [2142], 'maximize': [2144], 'extraction.': [2145], 'pooled': [2150], 'dried.': [2152], '32P-Labeled': [2153], '40%': [2161, 3265], '(w/v)': [2162, 2441], 'alkaline': [2163, 2589, 3266, 3878], 'acrylamide': [2164, 2620, 3879], 'electrophoresed': [2167], 'mA': [2171], '(18Dadd': [2175, 2591, 3881], 'C.A.': [2176, 2188, 2592, 3882], 'Cook': [2177, 2193, 2593, 3883], 'R.G.': [2178, 2194, 2594, 3884], 'Allis': [2179, 2197, 2595, 3885, 4935], 'C.D.': [2180, 2198, 2596, 3886, 4936], 'BioTechniques.': [2181, 2597, 3887], '14:': [2183, 2599, 3889], '266-273PubMed': [2184, 2600, 3890], '19Mizzen': [2187], 'Dou': [2189], 'Liu': [2191], 'Gorovsky': [2195], 'M.A.': [2196, 4880], 'Biol.': [2200, 3998, 4014, 4032, 4058, 4137, 4159, 5129, 5166, 5251, 5458], '274:': [2203], '14533-14536Abstract': [2204], '(35)': [2212], '20West': [2215, 2603, 3893], 'M.H.P.,': [2216, 2604, 3278, 3894], 'Wu,': [2217, 2605, 3279, 3895], 'R.S.': [2218, 2606, 3280, 3896], 'Bonner': [2219, 2607, 3281, 3897], 'W.M.': [2220, 2608, 3282, 3898], 'Electrophoresis.': [2221, 2609, 3283, 3899], '1984;': [2222, 2610, 3284, 3900], '5:': [2223, 2611, 3285, 3901], '133-138Crossref': [2224, 2612, 3286, 3902], '(73)': [2226, 2614, 3288, 3904], 'autoradiography,': [2238], 'radioactive': [2239, 2362, 2629, 3233, 3341, 3514, 3522, 3574], 'trifluoroacetic': [2249, 2279, 2297, 2309, 2346], '4': [2252, 2274], 'vigorous': [2258], 'shaking.': [2259], 'eluant': [2261, 3354], 'reserved.': [2265], 'further': [2270], 'fresh': [2277], 'acid.': [2280, 2310, 2347], 'eluants': [2283], 'combined': [2285, 3870], 'dried': [2287], 'evaporation.': [2289], 'Extracted': [2290], 'dissolved': [2293], '(v/v)': [2296, 2434], 'acid,': [2298], 'solutions': [2301], 'adjusted': [2303], '<2': [2306], 'RP-HPLC': [2311], 'C18': [2316], '(Vydac218TP52)': [2318], 'James': [2320, 2382], 'Lee': [2321, 2383, 5700], 'Facility,': [2327, 2389], 'Institute.': [2330, 2392], 'linear': [2337], 'gradient': [2338], '0': [2340], '70%': [2342], 'acetonitrile': [2343], 'Fractions': [2348], 'collected': [2350, 3359], 'every': [2351], 's,': [2353], 'monitored': [2357, 3361], 'Cerenkov': [2359, 3569], 'HPLC': [2363, 3342, 3483, 3504, 3515, 3523, 3575], 'fractions': [2364, 3383, 3484], 'sequencing': [2369, 2466], 'time': [2375, 3111], 'flight': [2377], '(MALDI-TOF)': [2380], 'sequencing,': [2394, 2642], 'phosphopeptides': [2395], 'coupled': [2397], 'Immobilon-AA': [2399], '(Millipore': [2400], 'Corp.)': [2401], 'according': [2402], "manufacturer's": [2405], 'instructions': [2406], 'prior': [2407, 5730], 'sequencing.': [2409], 'Applied': [2415], 'Biosystems': [2416], '477A': [2417], 'system': [2418, 3909], '(Dana-Farber': [2425], 'Institute)': [2427], 'techniques': [2430], '90%': [2433], 'methanol': [2435], '15': [2437], 'ml': [2438, 2444], '85%': [2440], 'phosphoric': [2442], 'acid/100': [2443], 'employed': [2446, 2485], 'extraction': [2449], 'because': [2450, 3836], 'gave': [2452], 'better': [2453], 'recovery': [2454], 'derivatives.': [2457], 'An': [2458], 'in-line': [2459], 'split': [2460], 'diverted': [2461], 'each': [2465, 2528, 3356, 3479, 3506, 3521, 3573, 3781, 4227], 'cycle': [2467, 3357], 'fraction': [2470, 3343, 3422], 'collector': [2471], 'determine': [2473, 3104, 3408], '32P': [2474], 'content': [2475], 'counting': [2479, 3518, 3570], 'while': [2480], 'remaining': [2482], 'identification': [2488, 5515], 'RP-HPLC.': [2490, 3318], 'Dr.': [2495], 'Charles': [2496], 'Dahl': [2497, 5694], 'Biopolymer': [2500], '(Department': [2502], 'Biological': [2504], 'Chemistry': [2505], 'Pharmacology,': [2508], 'Harvard': [2509], 'Medical': [2510], 'School).': [2511], 'Each': [2512, 3307, 3340], 'verified': [2515], 'composition,': [2523], 'solution': [2529], 'analysis.': [2535], 'In': [2536, 5309, 5352], 'stacking': [2542, 2548], '5%': [2547], 'Tris-glycine': [2551, 3867], 'SDS-PAGE': [2552, 3868], '(21Sambrook': [2553], 'Fritsch': [2555], 'E.F.': [2556], 'Maniatis': [2557], 'Cloning:': [2560], 'Laboratory': [2562], '2nd': [2564], 'Cold': [2566, 2570], 'Spring': [2567, 2571], 'Harbor': [2568], 'Laboratory,': [2569], 'Harbor,': [2572], 'NY1989:': [2573], '18.47-18.53Google': [2574], 'Scholar),': [2575, 2871, 4068, 4712, 4896, 4923, 5617], 'resolving': [2578, 3874], 'running': [2581], 'composition': [2586], 'used': [2587, 2974, 4449], '30%': [2619], '(acrylamide/bisacrylamide': [2621], '=': [2622], '30:0.037)': [2623], 'used.': [2625], 'When': [2626, 2986, 4182], 'appropriate,': [2627], 'extracted,': [2633], 'above.': [2645], 'autophosphorylates': [2654], 'threonine': [2658], 'find': [2682, 4991], 'study': [2688, 3113, 4988], 'tested': [2693, 2729, 3796, 4950], 'number': [2695, 3450], 'common': [2697], 'kinases.': [2701, 4732, 5568], 'Of': [2702], 'these,': [2703], 'H1,': [2705], 'H3': [2708, 4786], 'mixtures': [2711], 'most': [2713, 2906, 3693, 3977, 4254, 4275, 4329, 4337, 5190, 5206, 5269], 'robustly': [2714], 'GST-UL97.': [2718], 'initially': [2728], 'low': [2738], 'salt': [2739], '(<5': [2740], 'NaCl).': [2742], 'Under': [2743, 3033], '(Fig.1A,': [2746, 2899], 'lane': [2747, 2900, 3007, 3012, 3044], '1),': [2748, 3045], 'efficiently': [2751], 'radiolabeled': [2752, 2763], 'presence': [2755, 2802], '[γ-32P]ATP': [2757], '(which': [2760], 'became': [2762], 'autophosphorylation;': [2766], 'more': [2768, 3144, 3147], 'faintly': [2769], 'labeled': [2770], 'species': [2771, 3272, 3299, 3311, 3378, 3393, 3413, 3431, 3443, 3467, 3472, 3487], 'between': [2772, 3723], 'co-migrates': [2776], 'H1': [2779, 4788], 'probably': [2782], 'contaminant': [2784, 2922, 4433], 'commercial': [2787, 2969], 'preparation).': [2789], 'Much': [2790], 'less': [2791, 2818], 'observed': [2799, 2821, 2947], 'maribavir': [2804, 3026, 4955], '(lane': [2805, 2838, 2935], '2),': [2806, 2965, 3013], 'activity3': [2813], '(see': [2814], 'below).': [2815], 'Similarly,': [2816], 'much': [2817, 5387], 'radiolabeling': [2819, 2939, 2997], 'form': [2825, 3439, 3463, 3495, 4455], '(K355Q)': [2828, 4458], 'contains': [2830, 2978, 4293], 'instead': [2832], '355': [2837], '3).': [2839, 2901], 'Lys-355': [2840], 'corresponds': [2841], 'invariant': [2844], 'crucial': [2854], 'enzyme': [2856, 2925, 3148, 3912, 4436, 4445, 4726], '(22Hanks': [2858], 'S.K.': [2859, 5413], '576-596Crossref': [2866, 5420], '(2290)': [2869, 5423], 'eliminates': [2875, 5294], 'indicated': [2904], 'Fig.': [2913, 3010], '1A': [2914], 'neither': [2928], 'mutation,': [2932], 'nor': [2933], '4)': [2936], 'completely': [2937], 'residual': [2943, 2996], 'when': [2948, 5086], 'absence': [2957, 3000], '(Fig.': [2960, 3005, 3027, 3042, 3116, 3666, 4097, 4216, 4299, 4373, 5323], '1B,': [2961, 3006], 'lanes': [2962, 3029], 'indicating': [2966, 3163], 'preparation': [2970], 'experiments': [2977, 3095], 'small': [2979], 'increased': [2991], '3,': [3008], '1C,': [3011, 3028, 3043], '4).': [3032], 'conditions,': [3035], 'strong': [3041, 4229], 'being': [3046, 3632, 3643, 5204], 'reduced': [3047, 3060], 'only': [3048, 3670, 3702, 4190, 4442], 'about': [3049, 5472], '20%': [3050], '(Fig.1D).': [3051], 'Higher': [3052], 'up': [3056, 5386], 'm,': [3059], 'did': [3062, 3156], '(Fig.1D)': [3069], 'stimulated': [3071], 'Scholar).4Subsequent': [3094], 'mmNaCl.': [3102], 'stoichiometry': [3106], 'phosphorylation,': [3109], 'course': [3112], '2).': [3117], 'After': [3118], 'incorporation': [3127, 3160], 'phosphate': [3129, 3624, 3728], 'reached': [3130, 3153], 'maximum': [3132], 'nearly': [3134], 'mol': [3136, 3726], 'phosphate/mol': [3138], 'reaction': [3151], 'had': [3152, 3249], 'value': [3155], 'increase': [3158], 'phosphate,4': [3162], 'complete.': [3172], 'acid(s)': [3208], '32P-labeled': [3214], 'hydrolyzed,': [3217], 'electrophoresis.': [3229], 'Essentially': [3230], 'acids': [3235], 'co-migrated': [3236], 'phosphoserine': [3238], '(Fig.3A).': [3239], 'residues': [3245, 3620, 3747, 3760, 5085, 5184, 5357, 5473], 'phosphorylated,32P-labeled': [3246], 'trypsin.': [3257], 'through': [3263, 5187], 'polyacrylamide': [3267], 'separate': [3270, 3911], 'corresponding': [3274, 3435, 3459, 3491, 3775, 5101], 'nonphosphorylated': [3275, 3462], '(20West': [3277], 'As': [3291, 4241], 'Fig.3B,': [3294], 'five': [3297, 3310, 3617, 3673, 3734, 3784], 'major': [3298, 3392, 3442, 3471], '(TP1–TP5)': [3300], 'contained': [3302, 3400, 3429, 3485, 3701, 4074], '>95%': [3303], 'radioactivity.': [3306], 'eluted,': [3314], 'Single': [3319], 'peaks': [3320, 3329, 3526, 3579], 'TP1–TP4,': [3326], 'TP5': [3335], '(TP5-A,': [3336], 'TP5-B,': [3337, 3629], 'TP5-C).': [3339], 'sequenced': [3345, 3498], 'Edman': [3347], 'degradation,': [3348], 'radioactivity,': [3363, 3708], '(Fig.4).': [3370], 'Sequence': [3371, 4195], 'consistent': [3373, 3389, 3658, 5107, 5333], 'single': [3376], 'TP2,': [3385], 'yielded': [3387], 'minor': [3395, 3455, 3466], 'species,': [3396, 3456], '6.': [3406], 'whether': [3417], 'TP2': [3421], 'MALDI-TOF.': [3426], 'spectrum': [3428, 3477], 'monophosphorylated': [3438, 3494, 4191], 'predicted': [3444, 4215], '(accession': [3449], '70719),': [3451], '(Table': [3473, 3500, 3710], 'I).': [3474, 3711], 'MALDI-TOF': [3476], 'I).Table': [3501], 'ISummary': [3502], 'fractionsBandHPLC': [3516], 'fractionRadioactivity1-aCerenkov': [3517], 'fraction.Mass1-bMasses': [3524], '(MALDI-TOF).Predicted': [3529], 'sequence1-cThe': [3533], 'fragments': [3535, 3585], 'derived': [3538, 3588, 4325], 'masses': [3541, 3591], 'program': [3543, 3593], 'MS-Digest': [3544, 3594], '(ProteinProspector': [3545, 3595], 'Version': [3546, 3596], '3.2.1)': [3547, 3597], 'available': [3548, 3598], 'World': [3551, 3601], 'Wide': [3552, 3602], 'Web': [3553, 3603], 'http://prospector.ucsf.edu.mincpmTP13712,0001345.734KESYSVYVYK43+': [3555], 'phosphateTP2234,00070373IAGEASR7911731PEPAKSAPAPK11': [3556], '+': [3557, 3559, 3561, 3563, 3565, 3567], 'phosphateTP33812,5001217.935ESYSVYVYK43': [3558], 'phosphateTP41514,000744.787STITSR92': [3560], 'phosphateTP5-A136,000908.5109HAVSEGTK116': [3562], 'phosphateTP5-B115,500650.76SAPAPK11': [3564], 'phosphateTP5-C94,000666.2121YTSSK125': [3566], 'phosphate1-a': [3568], 'fraction.1-b': [3576], 'Masses': [3577], '(MALDI-TOF).1-c': [3582], 'http://prospector.ucsf.edu.': [3605], 'Open': [3606], 'table': [3607], 'tab': [3611], 'Taken': [3612], 'together,': [3613], 'incorporation:': [3625], 'Ser-6': [3626, 3688, 3743], '(TP2': [3627], 'latter': [3631, 3642, 4070], 'complete': [3634, 3645], 'digestion': [3635, 3646], 'product),': [3636, 3647], '(TP1': [3638], 'TP3,': [3640], 'Ser-87': [3648, 3685, 3974], '(TP4),': [3649], 'Ser-112': [3650, 3698], '(TP5-A),': [3651], 'Ser-124': [3653, 3700], '(TP5-C).': [3654], 'are': [3657, 4524, 4900, 5089, 5189, 5268, 5364], '3A)': [3667], 'showed': [3669], 'phosphoserine.': [3671], 'utilized': [3676, 3694], 'differing': [3678], 'extents.': [3679], '(42%': [3681], 'radioactivity),': [3684], '(24%),': [3686], '(16%)': [3689], '7%': [3705], 'respectively': [3709], 'weak': [3714, 3953], 'accounts': [3719], 'discrepancy': [3722], 'incorporated/mol': [3729], 'detected.': [3737], 'Interestingly,': [3738, 4268], 'contain': [3745, 3767, 4259, 5274], 'diverse': [3746, 5180], 'around': [3751], '(P+5),': [3762], 'where': [3763, 3971], 'basic': [3769, 4295, 5370], '(Lys': [3771], 'Arg).': [3773], 'portions': [3777], '(SP-6,': [3787], 'SP-38,': [3788, 5678], 'SP-87,': [3789, 3930], 'SP-112,': [3790], 'SP-124)': [3792], 'monitor': [3805], 'involves': [3808], 'filter-binding': [3810], 'assay': [3811, 3833], '(23Glass': [3812], 'D.B.': [3813, 3994, 4010, 4129, 4149], 'Masaracchia': [3814], 'R.A.': [3815, 4878], 'Feramisco': [3816], 'J.R.': [3817], 'Kemp': [3818, 4132, 5145], 'B.E.': [3819, 4133, 5146, 5158], 'Biochem.': [3821], '1978;': [3822], '87:': [3823], '566-575Crossref': [3824], '(248)': [3827], 'problematic,': [3835], 'obscured': [3840], 'signal': [3842], 'phosphorylation.4': [3846], 'overcome': [3848], 'problem,': [3850], '"chimeric"': [3853], 'technique': [3856], 'developed,': [3858], 'SDS-containing': [3862], '"stacking"': [3863], 'detergent-free': [3873], 'Using': [3907], 'peptide,': [3914, 4223], '(SP38)': [3923], 'readily': [3925, 5379], '(Fig.5).': [3929], 'extensively.': [3939], 'Faint': [3940], 'SP-6': [3944], 'discerned': [3948], 'longer': [3951], 'exposure,': [3952], 'correlates': [3961], 'well': [3962, 4236], 'full-length': [3969], 'highly': [3978, 5210], 'followed': [3981, 5618], 'SP6.': [3983], 'studied': [3992, 4096], '(24Glass': [3993], 'Krebs': [3995, 4011, 5163], 'E.G.': [3996, 4012, 5164], '1979;': [4000], '254:': [4001], '9728-9738Abstract': [4002], '25Glass': [4009], '1982;': [4016], '257:': [4017], '1196-1200Abstract': [4018], '26Hashimoto': [4025], 'Takeda': [4027, 4053], 'Nishizuka': [4029, 4055], '1976;': [4034, 4060], '251:': [4035, 4061], '6287-6293Abstract': [4036, 4062], 'phosphorylates': [4044], 'Ser-32': [4046], 'Ser-36': [4048, 4205, 5103], '(26Hashimoto': [4051], 'SP38.': [4077], 'compare': [4079], 'specificities': [4081], 'SP-38': [4089, 4101, 4173], '(RKESYSVYVYKV)': [4090], '6A).': [4098], 'PKA,': [4106, 4114, 5075, 5114], 'PKI,': [4121], 'pseudosubstrate': [4124], '(27Glass': [4128], 'Cheng': [4130, 4150], 'H.-C.': [4131, 4151], 'Walsh': [4134, 4156], 'D.A.': [4135, 4157, 5232, 5439, 5592], '1986;': [4139], '261:': [4140], '12166-12171Abstract': [4141], '28Glass': [4148], 'Mende-Muller': [4152], 'Reed': [4154], '264:': [4162], '8802-8810Abstract': [4163], 'Moreover,': [4170, 5552], 'substitution.': [4181], 'MALDI-TOF,': [4189, 5703], 'forms': [4192, 4714], 'observed.4': [4194], '6B).': [4217], 'presented': [4219, 4739, 5090], 'particular': [4233], 'distinct': [4238], 'specificities.': [4240], 'noted': [4242], 'H2B-derived': [4252, 4414], 'position.': [4267, 4394, 5282, 5483], 'autophosphorylated': [4277, 4339], '5M.': [4280], 'preparation.also': [4292], '5B).': [4300, 5324], 'raised': [4303], 'possibility': [4305], 'distal': [4309, 5302], 'might': [4312, 5037], 'important': [4314, 5191, 5218, 5306], 'test': [4320], 'hypothesis,': [4322], 'UL97,5': [4342], 'place': [4348], 'synthesized.': [4358], 'eliminated,': [4366], 'compared': [4367], 'counterparts': [4372], '7).': [4374], 'depends': [4384], 'identity': [4387], 'work': [4396, 4738], 'here': [4398, 4740], 'documents': [4399], 'substrate,': [4409, 5677], 'Ser': [4418, 5084, 5100], 'show': [4421], 'conclusively': [4422], 'than': [4430], 'preparation,': [4439], 'catalytically': [4452], 'inactive,': [4453], 'inhibitor,': [4463], 'family': [4475, 4523, 4761], '10Chee': [4497], 'reported': [4517], 'members': [4520], 'capable': [4525], 'phosphorylating': [4527], 'vitro,': [4532], 'preparations': [4535, 4727], '(8de': [4538], '29Ng': [4553], 'T.I.': [4554], 'Grose': [4555, 4629, 4701], 'Virology.': [4557, 4582, 4846, 4918], '191:': [4559], '9-18Crossref': [4560], '(52)': [4563], '30Daikoku': [4566], 'Shibata': [4568], 'Goshima': [4570], 'F.': [4571], 'Oshima': [4572], 'Tsurumi': [4574], 'Yamada': [4576], 'H.': [4577, 4608, 4680, 4914, 5125], 'Yamashita': [4578], 'Nishiyama': [4580], '235:': [4584], '82-93Crossref': [4585], '(45)': [4588], '31Ansari': [4591], 'Emery': [4593], 'V.C.': [4594], '3284-3291Crossref': [4599], '32Chen': [4603], 'M.-R.': [4604, 4676], 'Chang': [4605, 4677], 'S.-J.': [4606, 4678], 'Huang': [4607, 4679], 'Chen': [4609, 4681], 'J.-Y.': [4610, 4682], '2000;': [4613, 4685, 5605], '74:': [4614, 4686], '3093-3104Crossref': [4615, 4687], '(94)': [4618, 4690], '33Kenyon': [4621, 4693], 'T.K.': [4622, 4694], 'Lynch': [4623, 4695], 'Hay': [4625, 4697], 'Ruyechan': [4627, 4699], '75:': [4634, 4706], '8854-8858Crossref': [4635, 4707], '(66)': [4638, 4710, 4852], 'reports,': [4644], 'enzymes': [4646], 'and/or': [4651], 'inactivating': [4658], 'point': [4659, 5684], 'mutation': [4660], 'substrates.': [4670], 'Indeed,': [4671, 5283], 'cases': [4674], '(32Chen': [4675], 'akin': [4715], 'retained': [4719], 'substantial': [4720], 'activity,': [4722], 'suggesting': [4723], 'contaminated': [4729], 'Regardless,': [4733], 'our': [4735, 5494], 'knowledge,': [4736], 'demonstrate': [4745], 'especially': [4754, 5532], 'already': [4759], 'describe': [4769], 'any': [4774, 5475], 'family.': [4778], 'Aside': [4779], 'vitro.4': [4790], 'inconceivable': [4794], 'physiologically': [4799], 'relevant': [4800], 'localized': [4806], 'HCMV-infected': [4811], '(34Michel': [4813], 'Pavic': [4815], 'I.': [4816], 'Zimmermann': [4817], 'Haupt': [4819], 'Wunderlich': [4821], 'Heuschmid': [4823], 'Mertens': [4825], '6340-6346Crossref': [4831], '35van': [4835], 'Zeijl': [4836], 'Fairhurst': [4838], 'Baum': [4840], 'E.Z.': [4841], 'Sun': [4842], 'Jones': [4844], 'T.R.': [4845, 5234, 5441], '231:': [4848], '72-80Crossref': [4849], 'affect': [4860, 4903], 'host': [4861], '(reviewed': [4864, 4906], 'Ref.': [4866, 4908], '36Mocarski': [4867], 'Knipe': [4871], 'Howley': [4873], 'P.M.': [4874], 'Griffin': [4875], 'D.E.': [4876], 'Lamb': [4877], 'Martin': [4879, 5637], 'Straus': [4883], 'S.E.': [4884], 'Fields': [4885], 'Virology,': [4886], '2.': [4887], '4th': [4888], 'Lippincott': [4890], 'Williams': [4891], '&': [4892], 'Wilkins,': [4893], 'Philadelphia2001:': [4894], '2629-2673Google': [4895], 'herpesviruses': [4899], 'chromatin': [4904], 'condensation': [4905], '37Roizman': [4909], 'Furlong': [4911], 'Fraenkel-Contrat': [4913], 'Wagner': [4915], 'R.R.': [4916], 'Comprehensive': [4917], 'Plenum,': [4919], 'New': [4920], 'York1974:': [4921], '229-403Google': [4922], 'regulated': [4929], '(38Jenuwein': [4933], 'Science.': [4937], '293:': [4939], '1074-1080Crossref': [4940], '(7666)': [4943], 'possibilities': [4947], 'deletion': [4958], 'mutants': [4959], 'goal': [4985], 'clues': [4992], 'understand': [5002], 'mechanism': [5004], 'help': [5009], 'predict': [5010], 'intracellular': [5011], 'enzyme.': [5015], 'Sites': [5016], 'identified.': [5027], 'anticipated': [5029], 'characteristics': [5040], 'analogues,': [5048], 'divergence': [5051], 'optima.': [5061], 'That': [5062], 'differs': [5067], 'prototypic': [5072], 'kinase,': [5074], 'clearly': [5077], 'illustrated': [5078], '(SP-38).': [5095], 'consensus': [5111], '(R/K)XXS': [5115], '(39Songyang': [5116], 'Blechner': [5118], 'Hoagland': [5120], 'Hoekstra': [5122, 5241, 5448], 'M.F.': [5123, 5242, 5449], 'Piwnica-Worms': [5124], 'Cantley': [5126, 5247, 5454, 5601, 5717], 'L.C.': [5127, 5248, 5455, 5602], 'Curr.': [5128], '1994;': [5130], '4:': [5131], '973-982Abstract': [5132], '(537)': [5140], '40Pearson': [5143], 'R.B.': [5144], 'Methods': [5147], 'Enzymol.': [5148], '1991;': [5149], '200:': [5150], '62-81Crossref': [5151], '(871)': [5154], '41Kemp': [5157], 'Graves': [5159, 5237, 5444], 'Benjamini': [5161], '1977;': [5168], '252:': [5169], '4888-4894Abstract': [5170], 'generally,': [5178], 'P-3': [5186], 'P+3': [5188], 'P−3': [5197, 5371], '(e.g.': [5198], 'PKA)': [5199], 'P+1': [5201, 5390], 'usually': [5203], 'crucial;': [5207], '(42Songyang': [5219], 'Lu,': [5221, 5428], 'K.P.': [5222, 5429], 'Kwon': [5223, 5430], 'Y.T.': [5224, 5431], 'Tsai': [5225, 5432], 'L.-H.': [5226, 5433], 'Filhol': [5227, 5434], 'Cochet': [5229, 5436], 'Brickey': [5231, 5438], 'Soderling': [5233, 5440], 'Bartleson': [5235, 5442], 'Demaggio': [5239, 5446], 'A.J.': [5240, 5447], 'Blenis': [5243, 5450], 'Mol.': [5249, 5456, 5603], '16:': [5253, 5460], '6486-6493Crossref': [5254, 5461], '(489)': [5257, 5464], 'reveal,': [5262], 'however,': [5263], 'very': [5305], 'contrast,': [5310], 'obvious': [5314], 'similarities': [5315], 'importance': [5327], 'lack': [5336], 'conservation': [5338], 'subdomains': [5346, 5359], 'typically': [5347], 'involved': [5348], 'recognition.': [5351], 'particular,': [5353], 'lacks': [5355], 'acidic': [5356], 'VI': [5362], 'thought': [5365], 'stabilize': [5367], 'residues,': [5372], 'does': [5375], 'recognizable': [5380], 'VIII,': [5382], 'ordinarily': [5384], 'makes': [5385], 'Scholar,22Hanks': [5412], '42Songyang': [5426], 'At': [5467], 'present,': [5468], 'little': [5469], 'interact': [5479], 'Further': [5484], 'studies': [5485], 'should': [5492], 'advance': [5493], 'understanding': [5495], 'kinase-substrate': [5499], 'interaction.': [5500], 'permits': [5521], 'development': [5522, 5547, 5630], 'advantageous': [5533], 'since': [5542], 'facilitate': [5545], 'throughput': [5550], 'assays.': [5551], 'starting': [5558, 5683], 'points': [5559], 'design': [5562], 'peptidomimetic': [5564], 'Such': [5569], 'abetted': [5573], 'combinatorial': [5575], 'approaches': [5576], 'optimize': [5578], 'affinity': [5579], 'conversion': [5581, 5620], 'nonphosphorylatable': [5585], 'moieties': [5586], '(43Nishikawa': [5587], 'Sawasdikosol': [5589], 'Fruman': [5591], 'Lai': [5593], 'Songyang': [5595], 'Burakoff': [5597], 'S.J.': [5598], 'Yaffe': [5599], 'M.B.': [5600], '6:': [5606], '969-974Abstract': [5607], '(24)': [5615], 'peptidomimetics,': [5624], 'protease': [5632], '(44Roberts': [5635], 'N.A.': [5636], 'J.A.': [5638], 'Kinchington': [5639], 'Broadhurst': [5641], 'A.V.': [5642], 'Craig': [5643], 'Duncan': [5645], 'I.B.': [5646], 'Galpin': [5647], 'S.A.': [5648], 'Handa': [5649], 'B.K.': [5650], 'Kay': [5651], 'Krohn': [5653], 'Lambert': [5655], 'R.W.': [5656], 'Merrett': [5657], 'J.H.': [5658], 'Mills': [5659], 'J.S.': [5660], 'Parkes': [5661], 'K.E.B.': [5662], 'Redshaw': [5663], 'et': [5665], 'al.Science.': [5666], '1990;': [5667], '248:': [5668], '358-361Crossref': [5669], '(873)': [5672], 'serve': [5680], 'inhibitor.': [5689], 'gratefully': [5691], 'acknowledge': [5692], 'synthesis': [5696], 'peptides;': [5698], 'HPLC,': [5702], 'sequencing;': [5706], 'analysis;': [5712, 5723], 'laboratory': [5714], 'assistance': [5719], 'communication': [5727], 'publication;': [5732], 'Cantley,': [5735], 'Eck,': [5737], 'Roberts': [5742], 'helpful': [5744], 'discussions.': [5745]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054708202', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T19:30:23.611627', 'created_date': '2016-06-24'}
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