Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2054670640', 'doi': 'https://doi.org/10.1016/j.ceca.2005.11.008', 'title': 'ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells', 'display_name': 'ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells', 'publication_year': 2006, 'publication_date': '2006-04-01', 'ids': {'openalex': 'https://openalex.org/W2054670640', 'doi': 'https://doi.org/10.1016/j.ceca.2005.11.008', 'mag': '2054670640', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16445977'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ceca.2005.11.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80202938', 'display_name': 'Cell Calcium', 'issn_l': '0143-4160', 'issn': ['0143-4160', '1532-1991'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024538003', 'display_name': 'Seiko Kawano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Seiko Kawano', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044814082', 'display_name': 'Keishi Otsu', 'orcid': 'https://orcid.org/0000-0002-3954-9442'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keishi Otsu', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085462187', 'display_name': 'Akinori Kuruma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akinori Kuruma', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351-0198, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}, {'raw_affiliation_string': 'Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351-0198, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041031153', 'display_name': 'Satoshi Shoji', 'orcid': 'https://orcid.org/0000-0002-2223-7215'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Shoji', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}, {'raw_affiliation_string': 'Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033761613', 'display_name': 'Eri Yanagida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eri Yanagida', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048084616', 'display_name': 'Yuko Muto', 'orcid': 'https://orcid.org/0000-0002-5694-5041'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuko Muto', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}, {'raw_affiliation_string': 'Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103642363', 'display_name': 'Fumio Yoshikawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumio Yoshikawa', 'raw_affiliation_strings': ['Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065236305', 'display_name': 'Yoshiyuki Hirayama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80188885', 'display_name': 'Nippon Medical School', 'ror': 'https://ror.org/00krab219', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I80188885']}, {'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshiyuki Hirayama', 'raw_affiliation_strings': ['Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'Department of First Internal Medicine, Nippon Medical School, Tokyo 113-8603, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of First Internal Medicine, Nippon Medical School, Tokyo 113-8603, Japan', 'institution_ids': ['https://openalex.org/I80188885']}, {'raw_affiliation_string': 'Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan', 'institution_ids': ['https://openalex.org/I125602781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035555934', 'display_name': 'Katsuhiko Mikoshiba', 'orcid': 'https://orcid.org/0000-0002-3487-6970'}, 'institutions': [{'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}, {'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Katsuhiko Mikoshiba', 'raw_affiliation_strings': ['Calcium Oscillations Project, ICORP, JST, Saitama 332-0012, Japan', 'Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan', 'Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351-0198, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan', 'institution_ids': ['https://openalex.org/I161296585']}, {'raw_affiliation_string': 'Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351-0198, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}, {'raw_affiliation_string': 'Calcium Oscillations Project, ICORP, JST, Saitama 332-0012, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081018954', 'display_name': 'Teiichi Furuichi', 'orcid': 'https://orcid.org/0000-0002-9676-1888'}, 'institutions': [{'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Teiichi Furuichi', 'raw_affiliation_strings': ['Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan'], 'affiliations': [{'raw_affiliation_string': 'Molecular Neurogenesis, Brain Science Institute, RIKEN, Saitama 351-0198, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5024538003'], 'corresponding_institution_ids': ['https://openalex.org/I125602781'], 'apc_list': {'value': 3660, 'currency': 'USD', 'value_usd': 3660, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.102, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 145, 'citation_normalized_percentile': {'value': 0.9318, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '39', 'issue': '4', 'first_page': '313', 'last_page': '324'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Molecular Physiology of Purinergic Signalling', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nfat', 'display_name': 'NFAT', 'score': 0.9206336}, {'id': 'https://openalex.org/keywords/calcium-channels', 'display_name': 'Calcium Channels', 'score': 0.5367}, {'id': 'https://openalex.org/keywords/extracellular-atp', 'display_name': 'Extracellular ATP', 'score': 0.533329}, {'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.51729}, {'id': 'https://openalex.org/keywords/potassium-channels', 'display_name': 'Potassium Channels', 'score': 0.510155}, {'id': 'https://openalex.org/keywords/calcium-signaling', 'display_name': 'Calcium signaling', 'score': 0.48446727}], 'concepts': [{'id': 'https://openalex.org/C189938988', 'wikidata': 'https://www.wikidata.org/wiki/Q24744925', 'display_name': 'NFAT', 'level': 4, 'score': 0.9206336}, {'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.91060555}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.9105666}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.76279885}, {'id': 'https://openalex.org/C198826908', 'wikidata': 'https://www.wikidata.org/wiki/Q1922379', 'display_name': 'Mesenchymal stem cell', 'level': 2, 'score': 0.6044641}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.49157724}, {'id': 'https://openalex.org/C201571599', 'wikidata': 'https://www.wikidata.org/wiki/Q5018840', 'display_name': 'Calcium signaling', 'level': 3, 'score': 0.48446727}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45106485}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35237762}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.25457668}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15029973}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.14161646}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019898', 'descriptor_name': 'Autocrine Communication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050778', 'descriptor_name': 'NFATC Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019899', 'descriptor_name': 'Paracrine Communication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050156', 'descriptor_name': 'Adipogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050156', 'descriptor_name': 'Adipogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019898', 'descriptor_name': 'Autocrine Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017629', 'descriptor_name': 'Gap Junctions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017629', 'descriptor_name': 'Gap Junctions', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050778', 'descriptor_name': 'NFATC Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019899', 'descriptor_name': 'Paracrine Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011983', 'descriptor_name': 'Receptors, Purinergic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011983', 'descriptor_name': 'Receptors, Purinergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ceca.2005.11.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80202938', 'display_name': 'Cell Calcium', 'issn_l': '0143-4160', 'issn': ['0143-4160', '1532-1991'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16445977', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320912', 'funder_display_name': 'Ministry of Education, Culture, Sports, Science and Technology', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1485297825', 'https://openalex.org/W1563074426', 'https://openalex.org/W1574565179', 'https://openalex.org/W1598957092', 'https://openalex.org/W1599277155', 'https://openalex.org/W1650401181', 'https://openalex.org/W1666469474', 'https://openalex.org/W1901485302', 'https://openalex.org/W1930917734', 'https://openalex.org/W1964103059', 'https://openalex.org/W1964780858', 'https://openalex.org/W1978830171', 'https://openalex.org/W1978846938', 'https://openalex.org/W1989047764', 'https://openalex.org/W1997038940', 'https://openalex.org/W2005824184', 'https://openalex.org/W2010613687', 'https://openalex.org/W2038109343', 'https://openalex.org/W2039809463', 'https://openalex.org/W2045092834', 'https://openalex.org/W2046121936', 'https://openalex.org/W2055126519', 'https://openalex.org/W2057232267', 'https://openalex.org/W2064988794', 'https://openalex.org/W2071322539', 'https://openalex.org/W2072459093', 'https://openalex.org/W2082365979', 'https://openalex.org/W2085635882', 'https://openalex.org/W2088729275', 'https://openalex.org/W2096549360', 'https://openalex.org/W2109495864', 'https://openalex.org/W2111547035', 'https://openalex.org/W2113995373', 'https://openalex.org/W2117926778', 'https://openalex.org/W2120738384', 'https://openalex.org/W2121270780', 'https://openalex.org/W2127177109', 'https://openalex.org/W2130400575', 'https://openalex.org/W2131798248', 'https://openalex.org/W2135011583', 'https://openalex.org/W2136623476', 'https://openalex.org/W2150436014', 'https://openalex.org/W2157973267', 'https://openalex.org/W2158972964', 'https://openalex.org/W2159999899', 'https://openalex.org/W2168827068', 'https://openalex.org/W2169524467', 'https://openalex.org/W2314626866', 'https://openalex.org/W2490211911', 'https://openalex.org/W4249424055'], 'related_works': ['https://openalex.org/W3048253040', 'https://openalex.org/W3004047898', 'https://openalex.org/W2367035282', 'https://openalex.org/W2105493299', 'https://openalex.org/W2091727603', 'https://openalex.org/W2085869617', 'https://openalex.org/W2015867957', 'https://openalex.org/W1996832816', 'https://openalex.org/W1969354036', 'https://openalex.org/W1963652002'], 'abstract_inverted_index': {'Human': [0], 'bone': [1], 'marrow-derived': [2], 'mesenchymal': [3], 'stem': [4], 'cells': [5], '(hMSCs)': [6], 'have': [7, 32], 'the': [8, 25, 45, 58, 92, 107, 112, 132, 147, 153, 166, 173, 184, 189, 194, 205], 'potential': [9], 'to': [10, 116, 122, 129, 164, 180, 187], 'differentiate': [11], 'into': [12, 146, 204], 'several': [13], 'types': [14], 'of': [15, 29, 48, 62, 114, 169, 175, 196, 210], 'cells.': [16], 'Calcium': [17], 'ions': [18], '(Ca2+)': [19], 'play': [20], 'an': [21, 84, 97], 'important': [22], 'role': [23, 61], 'in': [24, 42, 66, 91, 111, 149, 213], 'differentiation': [26], 'and': [27, 60, 68, 127, 193, 207], 'proliferation': [28], 'hMSCs.': [30, 43, 151, 215], 'We': [31, 80, 119], 'demonstrated': [33], 'that': [34, 70, 83, 138, 172], 'spontaneous': [35, 63, 77], '[Ca2+]i': [36, 64, 78, 133, 139, 181, 190, 211], 'oscillations': [37, 65, 140, 191, 212], 'occur': [38], 'without': [39], 'agonist': [40], 'stimulation': [41], 'However,': [44], 'precise': [46], 'mechanism': [47, 59, 209], 'its': [49], 'generation': [50], 'remains': [51], 'unclear.': [52], 'In': [53, 94], 'this': [54, 95, 125], 'study,': [55], 'we': [56, 136], 'investigated': [57], 'hMSCs': [67, 185], 'found': [69, 82, 137], 'IP3-induced': [71], 'Ca2+': [72], 'release': [73], 'is': [74, 89, 99, 177], 'essential': [75], 'for': [76], 'oscillations.': [79, 93, 134, 182], 'also': [81], 'ATP': [85, 98, 154], 'autocrine/paracrine': [86, 155], 'signaling': [87, 156], 'pathway': [88, 157], 'involved': [90], 'pathway,': [96, 126], 'secreted': [100], 'via': [101], 'a': [102], 'hemi-gap–junction': [103], 'channel;': [104], 'it': [105, 160], 'stimulates': [106], 'P2Y1': [108], 'receptors,': [109], 'resulting': [110], 'activation': [113, 174], 'PLC-β': [115], 'produce': [117], 'IP3.': [118], 'were': [120, 141], 'able': [121], 'pharmacologically': [123], 'block': [124], 'thereby': [128], 'completely': [130], 'halt': [131], 'Furthermore,': [135], 'associated': [142], 'with': [143], 'NFAT': [144, 176, 197], 'translocation': [145, 168, 195], 'nucleus': [148], 'undifferentiated': [150, 214], 'Once': [152], 'was': [158, 161], 'blocked,': [159], 'not': [162], 'possible': [163], 'detect': [165], 'nuclear': [167], 'NFAT,': [170], 'indicating': [171], 'closely': [178], 'linked': [179], 'As': [183], 'differentiated': [186], 'adipocytes,': [188], 'disappeared': [192], 'ceased.': [198], 'These': [199], 'results': [200], 'provide': [201], 'new': [202], 'insight': [203], 'molecular': [206], 'physiological': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054670640', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-09-13T01:43:54.119600', 'created_date': '2016-06-24'}