Integrins Regulate the Intracellular Distribution of Eukaryotic Initiation Factor 4E in Platelets

Name: Work Video:
Duration: 3 min 30 s
Stephan Lindemann; Neal D. Tolley; Jennifer R. Eyre; Larry W. Kraiss; Tracey M. Mahoney; Andrew S. Weyrich
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3515, 3526, 3552, 3650, 3737, 3746, 3885, 3900, 3999, 4041, 4104, 4129, 4182, 4220, 4265, 4304, 4361, 4566, 4573, 4598, 4711, 4722, 4748, 4846, 4933, 4942, 5082, 5098, 5197], 'platelets': [7, 76, 260, 329, 514, 641, 712, 727, 1265, 1302, 1427, 1692, 1932, 2028, 2129, 2273, 2400, 2471, 2486, 3026, 3063, 3188, 3453, 3693, 3789, 3890, 4221, 4258, 4383, 4648, 4889, 4986, 5087], 'synthesize': [8, 261, 1266, 3027, 4222], 'numerous': [9, 262, 516, 1055, 1442, 2275, 2815, 3203, 4398], 'proteins': [10, 263, 971, 1267, 1941, 1995, 2122, 2731, 3028, 3702, 3756, 3883, 4223, 4898, 4952, 5080], 'in': [11, 75, 103, 146, 188, 264, 328, 356, 399, 441, 526, 640, 789, 839, 1034, 1143, 1219, 1268, 1425, 1436, 1587, 1739, 1776, 1868, 1883, 1946, 1980, 2015, 2027, 2042, 2128, 2152, 2211, 2223, 2239, 2267, 2285, 2399, 2548, 2598, 2794, 2904, 2980, 3029, 3186, 3197, 3348, 3500, 3537, 3629, 3644, 3707, 3741, 3776, 3788, 3803, 3889, 3913, 3972, 3984, 4000, 4028, 4098, 4174, 4224, 4381, 4392, 4543, 4695, 4733, 4825, 4840, 4903, 4937, 4972, 4985, 5000, 5086, 5111, 5170, 5182, 5198, 5226], 'a': [12, 185, 191, 265, 438, 444, 843, 891, 1172, 1195, 1269, 1608, 1627, 1647, 1742, 1788, 1819, 1844, 2036, 2602, 2651, 2933, 2956, 3030, 3369, 3388, 3408, 3503, 3549, 3580, 3605, 3797, 4127, 4150, 4225, 4564, 4583, 4603, 4698, 4745, 4776, 4801, 4994], 'signal-dependent': [13, 266, 1063, 1178, 1270, 1522, 2125, 2823, 2939, 3031, 3283, 3886, 4133, 4226, 4478, 5083], 'fashion': [14, 267, 1271, 3032, 4227], '(Pabla,': [15, 268], 'R.,': [16, 49, 52, 269, 302, 305], 'Weyrich,': [17, 42, 270, 295, 1581, 2205, 3342, 3966, 4537, 5164], 'A.': [18, 35, 43, 62, 70, 271, 288, 296, 315, 323, 574, 662, 795, 815, 1241, 1292, 1464, 1490, 1582, 2206, 2333, 2421, 2554, 2574, 3002, 3053, 3225, 3251, 3343, 3967, 4196, 4248, 4420, 4446, 4538, 5165, 5236], 'S.,': [19, 44, 272, 297, 1564, 2188, 3325, 3949, 4520, 5147], 'Dixon,': [20, 45, 273, 298, 1568, 2192, 3329, 3953, 4524, 5151], 'D.': [21, 46, 274, 299, 1476, 1569, 2193, 3237, 3330, 3954, 4432, 4525, 5152], 'A.,': [22, 47, 275, 300, 1570, 1579, 2194, 2203, 3331, 3340, 3955, 3964, 4526, 4535, 5153, 5162], 'Bray,': [23, 276], 'P.': [24, 277], 'F.,': [25, 278], 'McIntyre,': [26, 53, 279, 306, 1571, 2195, 3332, 3956, 4527, 5154], 'T.': [27, 54, 280, 307, 1572, 2196, 3333, 3957, 4528, 5155], 'M.,': [28, 31, 55, 58, 281, 284, 308, 311, 1573, 1576, 2197, 2200, 3334, 3337, 3958, 3961, 4529, 4532, 5156, 5159], 'Prescott,': [29, 56, 282, 309, 1574, 2198, 3335, 3959, 4530, 5157], 'S.': [30, 57, 69, 283, 310, 322, 573, 661, 799, 817, 1291, 1463, 1575, 1583, 2199, 2207, 2332, 2420, 2558, 2576, 3052, 3224, 3336, 3344, 3960, 3968, 4247, 4419, 4531, 4539, 5158, 5166], 'and': [32, 59, 150, 167, 229, 285, 312, 403, 420, 482, 638, 880, 890, 964, 991, 1223, 1342, 1508, 1527, 1535, 1562, 1580, 1668, 1780, 1835, 1877, 1998, 2069, 2085, 2096, 2101, 2147, 2158, 2204, 2230, 2243, 2397, 2640, 2650, 2724, 2751, 2984, 3103, 3269, 3288, 3296, 3323, 3341, 3429, 3541, 3596, 3638, 3759, 3830, 3846, 3857, 3862, 3908, 3919, 3965, 3991, 4004, 4178, 4298, 4464, 4483, 4491, 4518, 4536, 4624, 4737, 4792, 4834, 4955, 5027, 5043, 5054, 5059, 5106, 5117, 5163, 5189, 5202, 5238, 5246, 5253], 'Zimmerman,': [33, 60, 286, 313, 1577, 2201, 3338, 3962, 4533, 5160], 'G.': [34, 61, 287, 314, 1245, 1385, 1578, 2202, 3006, 3146, 3339, 3963, 4200, 4341, 4534, 5161], '(1999)': [36, 289], 'J.': [37, 290, 543, 693, 717, 758, 1551, 1678, 1702, 1708, 1710, 1723, 1913, 1962, 2176, 2302, 2452, 2476, 2517, 3312, 3439, 3463, 3469, 3471, 3484, 3674, 3723, 3937, 4507, 4634, 4658, 4664, 4666, 4679, 4870, 4919, 5135], 'Cell': [38, 291, 544, 694, 759, 978, 1008, 1552, 1585, 1680, 2177, 2209, 2303, 2453, 2518, 2738, 2768, 3313, 3346, 3441, 3938, 3970, 4508, 4541, 4636, 5136, 5168], 'Biol.': [39, 292, 545, 695, 760, 979, 1009, 1391, 1553, 1681, 1914, 1963, 2178, 2304, 2454, 2519, 2739, 2769, 3152, 3314, 3442, 3675, 3724, 3939, 4347, 4509, 4637, 4871, 4920, 5137], '144,': [40, 293], '175–184;': [41, 294], 'Pabla,': [48, 301], 'Elstad,': [50, 303], 'M.': [51, 304, 1492, 3253, 4448], '(1998)': [63, 316], 'Proc.': [64, 317, 568, 656, 1286, 1458, 2327, 2415, 3047, 3219, 4242, 4414], 'Natl.': [65, 318, 569, 657, 1287, 1459, 2328, 2416, 3048, 3220, 4243, 4415], 'Acad.': [66, 319, 570, 658, 1288, 1460, 2329, 2417, 3049, 3221, 4244, 4416], 'Sci.': [67, 320, 571, 659, 1289, 1461, 2330, 2418, 3050, 3222, 4245, 4417], 'U.': [68, 321, 572, 660, 1290, 1462, 2331, 2419, 3051, 3223, 4246, 4418], '95,': [71, 324], '5556–5561).': [72, 325], 'Protein': [73, 326], 'synthesis': [74, 327, 630, 673, 739, 852, 1435, 1652, 2127, 2161, 2389, 2432, 2498, 2611, 3196, 3413, 3888, 3922, 4391, 4608, 5085, 5120], 'is': [77, 144, 194, 199, 247, 330, 397, 447, 452, 500, 636, 887, 958, 1060, 1072, 1081, 1114, 1175, 1229, 1322, 1530, 1592, 1611, 1737, 1741, 1761, 1773, 1787, 1801, 1886, 1927, 1978, 1987, 2029, 2034, 2130, 2250, 2395, 2647, 2718, 2820, 2832, 2842, 2875, 2936, 2990, 3083, 3291, 3353, 3372, 3498, 3502, 3522, 3534, 3548, 3562, 3647, 3688, 3739, 3748, 3790, 3795, 3891, 4011, 4036, 4069, 4130, 4184, 4278, 4486, 4548, 4567, 4693, 4697, 4718, 4730, 4744, 4758, 4843, 4884, 4935, 4944, 4987, 4992, 5088, 5209], 'controlled': [78, 331, 874, 959, 1375, 2131, 2634, 2719, 3136, 3892, 4331, 5089], 'at': [79, 332, 740, 853, 875, 883, 1083, 1102, 1872, 2132, 2499, 2612, 2635, 2643, 2844, 2863, 3633, 3893, 4038, 4057, 4829, 5090, 5241], 'the': [80, 84, 124, 134, 147, 165, 180, 207, 215, 232, 242, 333, 337, 377, 387, 400, 418, 433, 460, 468, 485, 495, 633, 704, 741, 783, 854, 860, 884, 926, 1029, 1088, 1103, 1115, 1123, 1127, 1131, 1154, 1169, 1202, 1214, 1325, 1338, 1406, 1413, 1422, 1511, 1595, 1605, 1637, 1643, 1659, 1665, 1669, 1733, 1777, 1781, 1793, 1797, 1856, 1892, 1899, 1943, 1981, 2076, 2081, 2106, 2142, 2225, 2245, 2392, 2463, 2500, 2542, 2613, 2620, 2644, 2686, 2789, 2849, 2864, 2876, 2884, 2888, 2892, 2915, 2930, 2963, 2975, 3086, 3099, 3167, 3174, 3183, 3272, 3356, 3366, 3398, 3404, 3420, 3426, 3430, 3494, 3538, 3542, 3554, 3558, 3617, 3653, 3660, 3704, 3742, 3837, 3842, 3867, 3903, 3986, 4006, 4043, 4058, 4070, 4078, 4082, 4086, 4109, 4124, 4157, 4169, 4281, 4294, 4362, 4369, 4378, 4467, 4551, 4561, 4593, 4599, 4615, 4621, 4625, 4689, 4734, 4738, 4750, 4754, 4813, 4849, 4856, 4900, 4938, 5034, 5039, 5064, 5101, 5184, 5204, 5242, 5257], 'translational': [81, 236, 334, 489, 634, 742, 855, 895, 1197, 1317, 1332, 1423, 2040, 2393, 2501, 2614, 2655, 2958, 3078, 3093, 3184, 3801, 4152, 4273, 4288, 4379, 4998], 'level;': [82, 335], 'however,': [83, 336], 'mechanisms': [85, 338, 861, 1327, 2621, 3088, 4283], 'of': [86, 113, 153, 170, 177, 234, 245, 339, 366, 406, 423, 430, 487, 498, 786, 845, 929, 1032, 1038, 1058, 1076, 1079, 1099, 1130, 1133, 1157, 1204, 1207, 1217, 1233, 1340, 1408, 1421, 1524, 1597, 1619, 1634, 1662, 1757, 1796, 1803, 1874, 1894, 2005, 2022, 2025, 2078, 2083, 2108, 2112, 2120, 2145, 2155, 2227, 2248, 2258, 2545, 2604, 2689, 2792, 2798, 2818, 2836, 2840, 2860, 2891, 2894, 2918, 2965, 2968, 2978, 2994, 3101, 3169, 3182, 3285, 3358, 3380, 3395, 3423, 3518, 3557, 3564, 3635, 3655, 3766, 3783, 3786, 3839, 3844, 3869, 3873, 3881, 3906, 3916, 3988, 4009, 4019, 4034, 4054, 4085, 4088, 4112, 4159, 4162, 4172, 4188, 4296, 4364, 4377, 4480, 4553, 4575, 4590, 4618, 4714, 4753, 4760, 4831, 4851, 4962, 4979, 4983, 5036, 5041, 5066, 5070, 5078, 5104, 5114, 5186, 5207, 5217, 5256], 'regulation': [87, 340, 1100, 2024, 2861, 3785, 4055, 4982], 'are': [88, 98, 120, 206, 341, 351, 373, 459, 522, 728, 867, 872, 1151, 1303, 1314, 1410, 2281, 2487, 2627, 2632, 2912, 3064, 3075, 3171, 4106, 4259, 4270, 4366, 5232], 'not': [89, 342, 524, 868, 1695, 1748, 1938, 2030, 2116, 2283, 2628, 3456, 3509, 3699, 3791, 3877, 4651, 4705, 4895, 4988, 5074], 'known.': [90, 343, 869, 2629], 'Here': [91, 344, 1018, 1146, 2778, 2907, 4101], 'we': [92, 345, 621, 1019, 1147, 1403, 2380, 2779, 2908, 3164, 4102, 4359], 'demonstrate': [93, 346, 1020, 1213, 1753, 2780, 2974, 3514, 4168, 4710], 'translation': [95, 142, 348, 395, 785, 1141, 1523, 1663, 2072, 2265, 2544, 2902, 3284, 3424, 3833, 4026, 4096, 4479, 4619, 5030, 5224], 'initiation': [96, 130, 349, 383, 511, 885, 921, 1047, 1104, 1108, 1118, 2645, 2681, 2807, 2865, 2869, 2879, 4059, 4063, 4073], 'factors': [97, 350, 512, 993, 1109, 2753, 2870, 4064], 'redistributed': [99, 352], 'to': [100, 164, 179, 353, 417, 432, 779, 841, 901, 934, 966, 1049, 1090, 1168, 1185, 1194, 1316, 1344, 1380, 1510, 1594, 1599, 1863, 1942, 1948, 2007, 2241, 2260, 2538, 2600, 2661, 2694, 2726, 2809, 2851, 2929, 2946, 2955, 3077, 3105, 3141, 3271, 3355, 3360, 3624, 3703, 3709, 3768, 4002, 4021, 4045, 4123, 4140, 4149, 4272, 4300, 4336, 4466, 4550, 4555, 4820, 4899, 4905, 4964, 5200, 5219, 5234], 'mRNA-rich': [101, 181, 226, 354, 434, 479, 1170, 1187, 1512, 2261, 2931, 2948, 3273, 4022, 4125, 4142, 4468, 5220], 'areas': [102, 355, 2262, 4023, 5221], 'aggregated': [104, 357], 'platelets,': [105, 154, 358, 407, 1159, 1402, 1740, 1771, 2016, 2091, 2920, 3163, 3501, 3532, 3777, 3852, 4114, 4358, 4696, 4728, 4973, 5049], 'an': [106, 359, 1073, 1230, 1429, 1762, 1865, 2833, 2991, 3190, 3523, 3626, 4185, 4385, 4719, 4822], 'event': [107, 360], 'induces': [109, 362, 782, 2541], 'protein': [110, 138, 189, 363, 391, 442, 629, 672, 738, 851, 1064, 1093, 1179, 1211, 1434, 1651, 2094, 2126, 2160, 2388, 2431, 2497, 2610, 2824, 2854, 2940, 2972, 3195, 3412, 3855, 3887, 3921, 4048, 4134, 4166, 4390, 4607, 5052, 5084, 5119], 'synthesis.': [111, 364, 1180, 2941, 4135], 'Interrogation': [112, 365], 'cDNA': [114, 367], 'arrays': [115, 368], 'revealed': [116, 369], 'platelet-derived': [118, 371], 'mRNAs': [119, 372, 517, 521, 788, 933, 1150, 1379, 1409, 1529, 1602, 1635, 2276, 2280, 2547, 2693, 2911, 3140, 3170, 3290, 3363, 3396, 4105, 4335, 4365, 4485, 4558, 4591], 'primarily': [121, 374, 873, 2633], 'associated': [122, 375, 1152, 1411, 1603, 2231, 2913, 3172, 3364, 3992, 4107, 4367, 4559, 5190], 'with': [123, 172, 184, 225, 376, 425, 437, 478, 1153, 1412, 1601, 1604, 1626, 1636, 1855, 1992, 2914, 3173, 3362, 3365, 3387, 3397, 3616, 3753, 4108, 4368, 4557, 4560, 4582, 4592, 4812, 4949], 'cytoskeletal': [125, 227, 378, 480, 1051, 1155, 1351, 1382, 1414, 1606, 1638, 1734, 1944, 2811, 2916, 3112, 3143, 3175, 3367, 3399, 3495, 3705, 4110, 4307, 4338, 4370, 4562, 4594, 4690, 4901], 'core.': [126, 379], 'In': [127, 380, 953, 1400, 1655, 1769, 2090, 2713, 3161, 3416, 3530, 3851, 4356, 4611, 4726, 5048], 'contrast,': [128, 381], 'eukaryotic': [129, 382, 510, 1107, 1144, 2868, 2905, 4062, 4099], 'factor': [131, 384, 922, 1048, 1119, 2682, 2808, 2880, 4074], '4E': [132, 385, 923, 2683], '(eIF4E),': [133, 386], 'essential': [135, 388], 'mRNA': [136, 173, 389, 426, 902, 1080, 1341, 1629, 2662, 2841, 3102, 3390, 4035, 4297, 4585], 'cap-binding': [137, 390], 'controls': [140, 393, 708, 1766, 2467, 3527, 4723], 'global': [141, 394, 1140, 1196, 2901, 2957, 4095, 4151], 'rates,': [143, 396], 'localized': [145, 398], 'membrane': [148, 209, 401, 462, 1782, 1785, 1857, 1895, 1982, 2008, 3543, 3546, 3618, 3656, 3743, 3769, 4739, 4742, 4814, 4852, 4939, 4965], 'skeleton': [149, 402, 1786, 1858, 1983, 3547, 3619, 3744, 4743, 4815, 4940], 'soluble': [151, 404, 1778, 3539, 4735], 'fraction': [152, 405, 1779, 3540, 4736], 'physically': [155, 408, 1160, 1416, 2921, 3177, 4115, 4372], 'separated': [156, 409, 1161, 1417, 2922, 3178, 4116, 4373], 'most': [158, 411], 'mRNAs.': [159, 412, 1056, 1136, 2816, 2897, 4091], 'Platelet': [160, 413, 1164, 2925, 4119], 'activation': [161, 414, 626, 1165, 1949, 2385, 2926, 3710, 4120, 4906], 'redistributes': [162, 415, 1166, 1505, 2927, 3266, 4121, 4461], 'eIF4E': [163, 171, 178, 213, 246, 416, 424, 431, 466, 499, 956, 1000, 1033, 1041, 1059, 1077, 1113, 1138, 1167, 1184, 1208, 1228, 1509, 1598, 1623, 1758, 1767, 1772, 1977, 2006, 2013, 2026, 2079, 2084, 2100, 2146, 2249, 2259, 2716, 2760, 2793, 2801, 2819, 2837, 2874, 2899, 2928, 2945, 2969, 2989, 3270, 3359, 3384, 3519, 3528, 3533, 3738, 3767, 3774, 3787, 3840, 3845, 3861, 3907, 4010, 4020, 4068, 4093, 4122, 4139, 4163, 4183, 4465, 4554, 4579, 4715, 4724, 4729, 4934, 4963, 4970, 4984, 5037, 5042, 5058, 5105, 5208, 5218], 'cytoskeleton': [166, 182, 419, 435, 1644, 1670, 3405, 3431, 4600, 4626], 'increases': [168, 421, 628, 2387], 'interactions': [169, 422], 'cap': [174, 427, 1128, 1630, 2889, 3391, 4083, 4586], 'structures.': [175, 428], 'Redistribution': [176, 429, 1057, 2817], 'coincides': [183, 436], 'marked': [186, 439], 'increase': [187, 440], 'synthesis,': [190, 443, 1065, 1212, 2825, 2973, 4167], 'process': [192, 445, 1173, 2934, 4128], 'blocked': [195, 448], 'when': [196, 449], 'intracellular': [197, 235, 251, 450, 488, 504, 995, 1069, 1520, 2143, 2254, 2755, 2829, 3281, 3904, 4015, 4476, 5102, 5213], 'actin': [198, 451, 1805, 3566, 4762], 'disrupted.': [200, 453], 'Additional': [201, 454], 'studies': [202, 455, 770, 1930, 2529, 3691, 4887], 'demonstrated': [203, 456, 623, 1263, 1308, 2382, 3024, 3069, 4219, 4264], 'β3integrins': [205, 458], 'primary': [208, 461, 892, 2037, 2652, 3798, 4995], 'receptor': [210, 463, 1193, 2954, 4148], 'distributes': [212, 465], 'within': [214, 467, 1759, 1898, 2019, 3520, 3659, 3780, 4716, 4855, 4976], 'cell.': [216, 469], 'These': [217, 470, 830, 2589], 'results': [218, 471, 732, 831, 1307, 2235, 2491, 2590, 3068, 3996, 4263, 5194], 'imply': [219, 472], 'integrins': [221, 474, 736, 773, 857, 1026, 1044, 1182, 1218, 1330, 1507, 2495, 2532, 2617, 2786, 2804, 2943, 2979, 3091, 3268, 4137, 4173, 4286, 4463], 'link': [222, 475], 'receptor-mediated': [223, 476], 'pathways': [224, 477, 997, 2098, 2757, 3859, 5056], 'domains': [228, 481, 1052, 1383, 2812, 3144, 4339], 'thereby': [230, 483, 1878, 2148, 3639, 3909, 4835, 5107], 'modulate': [231, 484, 737, 2496], 'organization': [233, 486], 'complexes.': [237, 490], 'They': [238, 491], 'also': [239, 492, 1027, 1373, 1640, 1830, 1887, 2011, 2236, 2787, 3134, 3401, 3591, 3648, 3772, 3997, 4329, 4596, 4787, 4844, 4968, 5195], 'indicate': [240, 493, 733, 2237, 2492, 3998, 5196], 'functional': [243, 496, 639, 1030, 2246, 2398, 2790, 4007, 5205], 'status': [244, 497, 1031, 2247, 2791, 4008, 5206], 'regulated': [248, 501, 1082, 1650, 1746, 2251, 2843, 3411, 3507, 4012, 4037, 4606, 4702, 5210], 'by': [249, 502, 677, 837, 862, 960, 1025, 1312, 1328, 1377, 1441, 1613, 1653, 1929, 2074, 2214, 2252, 2436, 2596, 2622, 2720, 2785, 3073, 3089, 3138, 3202, 3374, 3414, 3690, 3835, 3975, 4013, 4268, 4284, 4333, 4397, 4569, 4609, 4886, 5032, 5173, 5211], 'its': [250, 503, 961, 2086, 2150, 2253, 2721, 3847, 3911, 4014, 5044, 5109, 5212], 'distribution.': [252, 505, 2255, 4016, 5214], 'interleukin': [506], 'polymerase': [507], 'chain': [508], 'reaction': [509], 'Although': [513, 2272, 2616, 4704], 'retain': [515, 2274], 'megakaryocytes,': [519, 2278], 'these': [520, 1186, 1306, 1437, 1860, 2109, 2121, 2279, 2947, 3067, 3198, 3621, 3870, 3882, 4141, 4262, 4393, 4817, 5067, 5079], 'generally': [523, 1693, 2282, 3454, 4649], 'translated': [525, 2284], 'quiescent': [527, 2286], 'cells': [528, 791, 1760, 2044, 2269, 2287, 2550, 3521, 3805, 4030, 4717, 5002, 5228], '(1Pabla': [529, 679, 744, 2162, 2288, 2438, 2503, 3923, 5121], 'R.': [530, 559, 647, 680, 745, 1277, 1449, 1538, 1672, 2163, 2289, 2318, 2406, 2439, 2504, 3038, 3210, 3299, 3433, 3924, 4233, 4405, 4494, 4628, 5122], 'Weyrich': [531, 681, 746, 1539, 2164, 2290, 2440, 2505, 3300, 3925, 4495, 5123], 'A.S.': [532, 555, 643, 682, 747, 1273, 1445, 1540, 2165, 2291, 2314, 2402, 2441, 2506, 3034, 3206, 3301, 3926, 4229, 4401, 4496, 5124], 'Dixon': [533, 556, 644, 683, 748, 1274, 1446, 1541, 2166, 2292, 2315, 2403, 2442, 2507, 3035, 3207, 3302, 3927, 4230, 4402, 4497, 5125], 'D.A.': [534, 557, 645, 684, 749, 1275, 1447, 1542, 2167, 2293, 2316, 2404, 2443, 2508, 3036, 3208, 3303, 3928, 4231, 4403, 4498, 5126], 'Bray': [535, 685, 750, 1543, 2168, 2294, 2444, 2509, 3304, 3929, 4499, 5127], 'P.F.': [536, 686, 751, 1544, 2169, 2295, 2445, 2510, 3305, 3930, 4500, 5128], 'McIntyre': [537, 562, 650, 687, 752, 1280, 1452, 1545, 2170, 2296, 2321, 2409, 2446, 2511, 3041, 3213, 3306, 3931, 4236, 4408, 4501, 5129], 'T.M.': [538, 563, 651, 688, 753, 1281, 1453, 1546, 2171, 2297, 2322, 2410, 2447, 2512, 3042, 3214, 3307, 3932, 4237, 4409, 4502, 5130], 'Prescott': [539, 564, 652, 689, 754, 1282, 1454, 1547, 2172, 2298, 2323, 2411, 2448, 2513, 3043, 3215, 3308, 3933, 4238, 4410, 4503, 5131], 'S.M.': [540, 565, 653, 690, 755, 1283, 1455, 1548, 2173, 2299, 2324, 2412, 2449, 2514, 3044, 3216, 3309, 3934, 4239, 4411, 4504, 5132], 'Zimmerman': [541, 566, 654, 691, 756, 1284, 1456, 1549, 2174, 2300, 2325, 2413, 2450, 2515, 3045, 3217, 3310, 3935, 4240, 4412, 4505, 5133, 5237], 'G.A.': [542, 567, 655, 692, 757, 1285, 1457, 1550, 2175, 2301, 2326, 2414, 2451, 2516, 3046, 3218, 3311, 3936, 4241, 4413, 4506, 5134], '1999;': [546, 696, 761, 912, 945, 1554, 2054, 2179, 2305, 2455, 2520, 2672, 2705, 3315, 3815, 3940, 4510, 5012, 5138], '144:': [547, 697, 762, 1555, 2180, 2306, 2456, 2521, 3316, 3941, 4511, 5139], '175-184Crossref': [548, 698, 763, 1556, 2181, 2307, 2457, 2522, 3317, 3942, 4512, 5140], 'PubMed': [549, 578, 595, 615, 666, 699, 723, 764, 807, 825, 915, 948, 983, 1013, 1257, 1296, 1365, 1395, 1468, 1498, 1557, 1685, 1715, 1728, 1922, 1971, 2057, 2182, 2308, 2337, 2354, 2374, 2425, 2458, 2482, 2523, 2566, 2584, 2675, 2708, 2743, 2773, 3018, 3057, 3126, 3156, 3229, 3259, 3318, 3446, 3476, 3489, 3683, 3732, 3818, 3943, 4212, 4252, 4321, 4351, 4424, 4454, 4513, 4641, 4671, 4684, 4879, 4928, 5015, 5141], 'Scopus': [550, 579, 596, 616, 667, 700, 765, 808, 826, 916, 949, 984, 1014, 1258, 1297, 1366, 1396, 1469, 1499, 1558, 1686, 1716, 1729, 2058, 2183, 2309, 2338, 2355, 2375, 2426, 2459, 2524, 2567, 2585, 2676, 2709, 2744, 2774, 3019, 3058, 3127, 3157, 3230, 3260, 3319, 3447, 3477, 3490, 3819, 3944, 4213, 4253, 4322, 4352, 4425, 4455, 4514, 4642, 4672, 4685, 5016, 5142], '(111)': [551, 701, 766, 1559, 2184, 2310, 2460, 2525, 3320, 3945, 4515, 5143], 'Google': [552, 581, 598, 618, 669, 702, 724, 767, 810, 828, 918, 951, 986, 1016, 1260, 1299, 1368, 1398, 1471, 1487, 1501, 1560, 1688, 1718, 1731, 1923, 1972, 2060, 2185, 2311, 2340, 2357, 2377, 2428, 2461, 2483, 2526, 2569, 2587, 2678, 2711, 2746, 2776, 3021, 3060, 3129, 3159, 3232, 3248, 3262, 3321, 3449, 3479, 3492, 3684, 3733, 3821, 3946, 4215, 4255, 4324, 4354, 4427, 4443, 4457, 4516, 4644, 4674, 4687, 4880, 4929, 5018, 5144], 'Scholar,': [553, 582, 599, 811, 1472, 1488, 1719, 2186, 2312, 2341, 2358, 2570, 3233, 3249, 3480, 3947, 4428, 4444, 4675, 5145], '2Weyrich': [554, 2313], 'Pabla': [558, 646, 1276, 1448, 2317, 2405, 3037, 3209, 4232, 4404], 'Elstad': [560, 648, 1278, 1450, 2319, 2407, 3039, 3211, 4234, 4406], 'M.R.': [561, 649, 1279, 1451, 2320, 2408, 3040, 3212, 4235, 4407], '1998;': [575, 663, 980, 1010, 1293, 1362, 1465, 2334, 2422, 2740, 2770, 3054, 3123, 3226, 4249, 4318, 4421], '95:': [576, 664, 1294, 1466, 2335, 2423, 3055, 3227, 4250, 4422], '5556-5561Crossref': [577, 665, 1295, 1467, 2336, 2424, 3056, 3228, 4251, 4423], '(236)': [580, 668, 1298, 1470, 2339, 2427, 3059, 3231, 4254, 4426], '3Booyse': [583, 2342], 'F.M.': [584, 1474, 2343, 3235, 4430], 'Hoveke': [585, 1477, 2344, 3238, 4433], 'T.P.': [586, 1478, 2345, 3239, 4434], 'Rafelson': [587, 1479, 2346, 3240, 4435], 'M.E.': [588, 1354, 1480, 2347, 3115, 3241, 4310, 4436], 'Biochim.': [589, 2348], 'Biophys.': [590, 609, 2349, 2368], 'Acta.': [591, 2350], '1968;': [592, 2351], '157:': [593, 2352], '660-663Crossref': [594, 2353], '(42)': [597, 2356], '4Roth': [600, 2359], 'G.J.': [601, 2360], 'Hickey': [602, 2361], 'M.J.': [603, 2362], 'Chung': [604, 2363], 'D.W.': [605, 2364], 'Hickstein': [606, 2365], 'D.D.': [607, 2366], 'Biochem.': [608, 911, 944, 1494, 1679, 1711, 2053, 2367, 2671, 2704, 3255, 3440, 3472, 3814, 4450, 4635, 4667, 5011], 'Res.': [610, 2369], 'Commun.': [611, 2370], '1989;': [612, 2371], '160:': [613, 2372], '705-710Crossref': [614, 2373], '(56)': [617, 2376], 'Scholar).': [619, 670, 725, 768, 829, 919, 952, 987, 1017, 1300, 1369, 1399, 1502, 1589, 1689, 1828, 1853, 1924, 1973, 2061, 2378, 2429, 2484, 2527, 2588, 2679, 2712, 2747, 2777, 3061, 3130, 3160, 3263, 3350, 3450, 3589, 3614, 3685, 3734, 3822, 4216, 4256, 4325, 4355, 4458, 4545, 4645, 4785, 4810, 4881, 4930, 5019], 'However,': [620, 1036, 1320, 2379, 2796, 3081, 4276], 'recently': [622, 2381], 'cellular': [625, 2384], 'globally': [627, 2386], 'indicating': [631, 2123, 2390, 3884, 5081], 'apparatus': [635, 2394], 'intact': [637, 2396], '(2Weyrich': [642, 1272, 1444, 2401, 3033, 3205, 4228, 4400], 'Regulated': [671, 2430], 'requires': [674, 2433], 'aggregation': [675, 1504, 1621, 2114, 2157, 2434, 3265, 3382, 3875, 3918, 4460, 4577, 5072, 5116], 'mediated': [676, 2435], 'αIIbβ3': [678, 735, 1043, 1181, 1313, 1836, 1890, 1997, 2215, 2437, 2494, 2803, 2942, 3074, 3597, 3651, 3758, 3976, 4136, 4269, 4793, 4847, 4954, 5174], 'Scholar),': [703, 1732, 2462, 3493, 4688], 'major': [705, 1116, 1660, 2464, 2877, 3421, 4071, 4616], 'integrin': [706, 2465], 'intercellular': [709, 2468], 'adhesion': [710, 778, 1346, 1861, 2469, 2537, 3107, 3622, 4302, 4818], 'among': [711, 2470], '(5Shattil': [713, 2472], 'S.J.': [714, 2473], 'Ginsberg': [715, 2474], 'M.H.': [716, 2475], 'Clin.': [718, 1493, 2477, 3254, 4449], 'Invest.': [719, 2478], '1997;': [720, 1392, 2479, 3153, 4348], '100:': [721, 2480], 'S91-S95Crossref': [722, 2481], 'Because': [726, 1301, 1690, 2485, 3062, 3451, 4257, 4646], 'anucleate': [729, 1304, 2488, 3065, 4260], 'cytoplasts,': [730, 2489], 'level': [743, 1098, 2502, 2859, 4053], 'Other': [769, 2528], 'have': [771, 2530], 'implicated': [772, 2531], 'as': [774, 1439, 1646, 2065, 2270, 2533, 3200, 3407, 3826, 4031, 4395, 4602, 5023, 5229], 'well,': [775, 2534], 'demonstrating': [776, 1616, 2535, 3377, 4572], 'extracellular': [780, 2539], 'matrix': [781, 2540], 'rapid': [784, 2543], 'preexisting': [787, 2546], 'nucleated': [790, 954, 2043, 2268, 2549, 2714, 3804, 4029, 5001, 5227], '(6Farmer': [792, 2551], 'S.R.': [793, 2552], "Ben-Ze'av": [794, 2553], 'Benecke': [796, 2555], 'B.J.': [797, 813, 2556, 2572], 'Penman': [798, 816, 2557, 2575], 'Cell.': [800, 818, 1390, 2559, 2577, 3151, 4346], '1978;': [801, 819, 2560, 2578], '15:': [802, 2561], '627-637Abstract': [803, 2562], 'Full': [804, 822, 1919, 1968, 2563, 2581, 3680, 3729, 4876, 4925], 'Text': [805, 823, 1920, 1969, 2564, 2582, 3681, 3730, 4877, 4926], 'PDF': [806, 824, 1921, 1970, 2565, 2583, 3682, 3731, 4878, 4927], '(100)': [809, 2568], '7Benecke': [812, 2571], "Ben-Ze'ev": [814, 2573], '14:': [820, 2579], '931-939Abstract': [821, 2580], '(184)': [827, 2586], 'suggest': [832, 2591], 'outside-in': [834, 1022, 2593, 2782], 'signals': [835, 1023, 1310, 2594, 2783, 3071, 4266], 'delivered': [836, 1024, 2595, 2784], 'integrins,': [838, 2597], 'addition': [840, 2240, 2599, 4001, 5199], 'regulating': [842, 2601], 'host': [844, 2603], 'other': [846, 1528, 1656, 1999, 2605, 3289, 3417, 3760, 4484, 4612, 4956, 5239], 'postligand': [847, 2606], 'binding': [848, 965, 1335, 1869, 2607, 2725, 3096, 3630, 4291, 4826], 'events,': [849, 2608], 'modulates': [850, 2609], 'level.Although': [856], 'regulate': [858, 1028, 1331, 2149, 2618, 2788, 3092, 3910, 4287, 5108], 'translation,': [859, 2619], 'which': [863, 1329, 1736, 2017, 2623, 3090, 3497, 3778, 4285, 4692, 4974], 'they': [864, 2624], 'do': [865, 1694, 1937, 2625, 3455, 3698, 4650, 4894], 'so': [866, 2626], 'Translation': [870, 2630, 4033], 'rates': [871, 1142, 2073, 2266, 2631, 2903, 3834, 4027, 4097, 5031, 5225], 'three': [876, 2636], 'steps:': [877, 2637], 'initiation,': [878, 2638], 'elongation,': [879, 2639], 'termination.': [881, 2641], 'Regulation': [882, 2642], 'phase': [886, 2646], 'considered': [888, 2035, 2648, 3796, 4993], 'predominant': [889, 2649], 'target': [893, 1045, 1183, 2038, 2653, 2805, 2944, 3799, 4138, 4996], 'for': [894, 1062, 1177, 1209, 1431, 1649, 1745, 1990, 2039, 2654, 2822, 2938, 2970, 3192, 3410, 3506, 3751, 3800, 4132, 4164, 4387, 4605, 4701, 4947, 4997, 5249], 'control': [896, 1092, 1318, 2041, 2141, 2264, 2656, 2853, 3079, 3802, 3902, 4025, 4047, 4274, 4999, 5100, 5223], 'because': [897, 1120, 2657, 2881, 4075], 'it': [898, 1121, 1986, 2033, 2658, 2882, 3747, 3794, 4076, 4943, 4991], 'recruits': [899, 2659], 'ribosomes': [900, 935, 1343, 2660, 2695, 3104, 4299], '(8Gingras': [903, 936, 2045, 2663, 2696, 3806, 5003], 'A.-C.': [904, 937, 2046, 2664, 2697, 3807, 5004], 'Raught': [905, 938, 2047, 2665, 2698, 3808, 5005], 'B.': [906, 939, 1247, 2048, 2666, 2699, 3008, 3809, 4202, 5006], 'Sonenberg': [907, 940, 2049, 2667, 2700, 3810, 5007], 'N.': [908, 941, 973, 1003, 1566, 1700, 2050, 2190, 2668, 2701, 2733, 2763, 3327, 3461, 3811, 3951, 4522, 4656, 5008, 5149], 'Annu.': [909, 942, 2051, 2669, 2702, 3812, 5009], 'Rev.': [910, 943, 2052, 2670, 2703, 3813, 5010], '68:': [913, 946, 2055, 2673, 2706, 3816, 5013], '913-963Crossref': [914, 947, 2056, 2674, 2707, 3817, 5014], '(1740)': [917, 950, 2059, 2677, 2710, 3820, 5017], 'Eukaryotic': [920, 2680], '(eIF4E)': [924, 2684], 'executes': [925, 2685], 'pivotal': [927, 2687], 'function': [928, 1235, 2151, 2688, 2996, 3912, 4190, 5110], 'bridging': [930, 2690], 'virtually': [931, 1134, 2691, 2895, 4089], 'all': [932, 1135, 2692, 2896, 4090], 'cells,': [955, 1305, 1438, 2715, 3066, 3199, 4261, 4394], 'activity': [957, 1001, 2717, 2761], 'transcription,': [962, 2722], 'phosphorylation,': [963, 2103, 2244, 2723, 3864, 4005, 5061, 5203], '4E-BP': [967, 2727], '(eIF4E-Binding': [968, 2728], 'Protein)': [969, 2729], 'repressor': [970, 2087, 2730, 3848, 5045], '(9Sonenberg': [972, 1002, 2732, 2762], 'Gingras': [974, 1004, 2734, 2764], 'A.C.': [975, 1005, 2735, 2765], 'Curr.': [976, 1006, 1388, 2736, 2766, 3149, 4344], 'Opin.': [977, 1007, 1389, 2737, 2767, 3150, 4345], '10:': [981, 1011, 2741, 2771], '268-275Crossref': [982, 1012, 2742, 2772], '(503)': [985, 1015, 2745, 2775], 'Cellular': [988, 2748], 'stress,': [989, 2749], 'cytokines,': [990, 2750], 'growth': [992, 2067, 2752, 3828, 5025], 'evoke': [994, 2754], 'signaling': [996, 1870, 2756, 3631, 4827], 'influence': [999, 2759], 'platelets.': [1035, 1654, 1884, 2153, 2795, 3415, 3645, 3914, 4610, 4841, 5112], 'instead': [1037, 2797], 'directly': [1039, 1189, 2799, 2950, 4144], 'influencing': [1040, 2800], 'activity,': [1042, 2802], 'this': [1046, 1191, 1221, 1591, 2806, 2952, 2982, 3352, 4146, 4176, 4547], 'subcellular': [1050, 2810], 'contain': [1054, 1349, 1696, 2814, 3110, 3457, 4305, 4652], 'required': [1061, 1176, 2821, 2937, 4131], 'providing': [1066, 2826], 'spatial': [1070, 1205, 1755, 2830, 2966, 3516, 4160, 4712], 'localization': [1071, 2831], 'important': [1074, 1231, 1763, 1866, 2834, 2992, 3524, 3627, 4186, 4720, 4823], 'determinant': [1075, 1232, 2835, 2993, 4187], 'function.DISCUSSIONTranslation': [1078], 'multiple': [1084, 2133, 2845, 3894, 4039, 5091], 'checkpoints': [1085, 2846, 4040], 'allow': [1087, 2848, 4042], 'cell': [1089, 1657, 1900, 2000, 2850, 3418, 3661, 3761, 4044, 4613, 4857, 4957], 'precisely': [1091, 2852, 4046], 'synthetic': [1094, 2855, 4049], 'patterns.': [1095, 2856, 4050], 'A': [1096, 2857, 4051], 'prominent': [1097, 2858, 4052], 'occurs': [1101, 2018, 2862, 3779, 4056, 4975], 'step': [1105, 2866, 4060], 'where': [1106, 1931, 2867, 3692, 4061, 4888], '(eIFs)': [1110, 2871, 4065], 'catalyze': [1111, 2872, 4066], 'translation.': [1112, 2873, 4067, 4703], 'rate-limiting': [1117, 2878, 4072], 'docks': [1122, 2883, 4077], 'eIF4F': [1124, 2885, 4079], 'complex': [1125, 2886, 4080], 'on': [1126, 2887, 4081], 'structure': [1129, 1790, 2890, 3551, 4084, 4747], '5′-terminus': [1132, 2893, 4087], 'Thus,': [1137, 2898, 4092], 'regulates': [1139, 1891, 2900, 3652, 4094, 4848], 'cells.': [1145, 2906, 4100], 'show': [1148, 2909, 4103], 'core': [1156, 1639, 1945, 2917, 3400, 3706, 4111, 4595, 4902], 'resting': [1158, 1401, 1426, 1770, 2919, 3162, 3187, 3531, 4113, 4357, 4382, 4727], 'eIF4E.': [1163, 1419, 2924, 3180, 4118, 4375], 'cytoskeleton,': [1171, 2932, 4126], 'areas,': [1188, 2949, 4143], 'linking': [1190, 2951, 4145], 'surface': [1192, 2001, 2953, 3762, 4147, 4958], 'checkpoint.': [1198, 2959, 4153], 'Our': [1199, 2234, 2960, 3995, 4154, 5093, 5193], 'findings': [1200, 2961, 4155], 'emphasize': [1201, 2962, 4156], 'importance': [1203, 2964, 4158], 'distribution': [1206, 1893, 2144, 2967, 3654, 3905, 4161, 4850, 5103], 'optimal': [1210, 2971, 4165], 'critical': [1215, 2976, 4170, 5254], 'role': [1216, 1867, 2977, 3628, 4171, 4824], 'mediating': [1220, 2981, 4175], 'response,': [1222, 2983, 4177], 'provide': [1224, 2136, 2985, 3897, 4179, 5095], 'further': [1225, 2986, 4180], 'platelet': [1234, 2156, 2995, 3917, 4189, 5115], '(16Rosenwald': [1236, 2997, 4191], 'I.B.': [1237, 2998, 4192], 'Pechet': [1238, 2999, 4193], 'L.': [1239, 1243, 1904, 1953, 3000, 3004, 3665, 3714, 4194, 4198, 4861, 4910], 'Han': [1240, 3001, 4195], 'Lu': [1242, 3003, 4197], 'Pihan': [1244, 3005, 4199], 'Woda': [1246, 3007, 4201], 'Chen': [1248, 3009, 4203], 'J.J.': [1249, 3010, 4204], 'Szymanski': [1250, 3011, 4205], 'I.': [1251, 3012, 4206], 'Thromb.': [1252, 1481, 3013, 3242, 4207, 4437], 'Haemost.': [1253, 3014, 4208], '2001;': [1254, 3015, 4209], '85:': [1255, 3016, 4210], '142-151Crossref': [1256, 3017, 4211], '(43)': [1259, 3020, 4214], 'Scholar).We': [1261, 3022], 'previously': [1262, 1749, 3023, 3510, 4218, 4706], 'transmitted': [1311, 3072, 4267], 'linked': [1315, 3076, 4271], 'pathways.': [1319, 3080, 4275], 'little': [1321, 3082, 4277], 'known': [1323, 3084, 4279], 'about': [1324, 3085, 4280], 'exact': [1326, 3087, 4282], 'events.': [1333, 2233, 3094, 3994, 4289, 5192], 'Integrin': [1334, 3095, 4290], 'can': [1336, 1372, 3097, 3133, 4292, 4328], 'induce': [1337, 3098, 4293], 'movement': [1339, 3100, 4295], 'focal': [1345, 3106, 4301], 'complexes': [1347, 3108, 4303], 'specific': [1350, 1628, 3111, 3389, 4306, 4584], 'components': [1352, 1897, 3113, 3658, 4308, 4854], '(18Chicurel': [1353, 3114, 4309], 'Singer': [1355, 1386, 3116, 3147, 4311, 4342], 'R.H.': [1356, 1387, 3117, 3148, 4312, 4343], 'Meyer': [1357, 3118, 4313], 'C.J.': [1358, 3119, 4314], 'Ingber': [1359, 3120, 4315], 'D.E.': [1360, 3121, 4316], 'Nature.': [1361, 3122, 4317], '392:': [1363, 3124, 4319], '730-733Crossref': [1364, 3125, 4320], '(315)': [1367, 3128, 4323], 'Gene': [1370, 3131, 4326], 'expression': [1371, 3132, 4327], 'be': [1374, 3135, 4330], 'locally': [1376, 3137, 4332], 'targeting': [1378, 1756, 2257, 3139, 3517, 4018, 4334, 4713, 5216], 'specialized': [1381, 3142, 4337], '(19Bassell': [1384, 3145, 4340], '9:': [1393, 3154, 4349], '109-115Crossref': [1394, 3155, 4350], '(202)': [1397, 3158, 4353], 'found': [1404, 1775, 1979, 3165, 3536, 3740, 4360, 4732, 4936], 'majority': [1407, 3168, 4363], 'core,': [1415, 1607, 3176, 3368, 4371, 4563], 'Segregation': [1420, 3181, 4376], 'machinery': [1424, 3185, 4380], 'provides': [1428, 3189, 4384], 'explanation': [1430, 3191, 4386], 'limited': [1432, 3193, 4388], 'constitutive': [1433, 3194, 4389], 'reported': [1440, 3201, 4396], 'investigators': [1443, 3204, 4399], '20Booyse': [1473, 3234, 4429], 'Zschocke': [1475, 3236, 4431], 'Diath.': [1482, 3243, 4438], 'Haemorrh.': [1483, 3244, 4439], '1971;': [1484, 1725, 3245, 3486, 4440, 4681], '26:': [1485, 3246, 4441], '167-176PubMed': [1486, 3247, 4442], '21Ludany': [1489, 3250, 4445], 'Kellermayer': [1491, 3252, 4447], '1988;': [1495, 3256, 4451], '21:': [1496, 3257, 4452], '107-110Crossref': [1497, 3258, 4453], '(8)': [1500, 3261, 4456], 'αIIbβ3-dependent': [1503, 1620, 2113, 3264, 3381, 3874, 4459, 4576, 5071], 'β3': [1506, 3267, 4462], 'cytoskeleton.': [1513, 3274, 4469], 'When': [1514, 3275, 4470], 'cytochalasin': [1515, 3276, 4471], 'D': [1516, 3277, 4472], 'or': [1517, 2080, 3278, 3841, 4473, 5038], 'αIIbβ3antagonists': [1518, 3279, 4474], 'disrupt': [1519, 3280, 4475], 'trafficking,': [1521, 3282, 4477], 'IL-1β,': [1525, 3286, 4481], 'Bcl-3,': [1526, 3287, 4482], 'inhibited': [1531, 3292, 4487], '(see': [1532, 3293, 4488], 'Fig.': [1533, 3294, 4489], '5': [1534, 3295, 4490], 'Refs.': [1536, 3297, 4492], '1Pabla': [1537, 3298, 4493], 'Scholar': [1561, 3322, 4517], '25Lindemann,': [1563, 2187, 3324, 3948, 4519, 5146], 'Tolley,': [1565, 2189, 3326, 3950, 4521, 5148], 'D.,': [1567, 2191, 3328, 3952, 4523, 5150], '(2001)J.': [1584, 2208, 3345, 3969, 4540, 5167], 'Biol.,': [1586, 2210, 3347, 3971, 4542, 5169], 'press.Google': [1588, 2212, 3349, 3973, 4544, 5171], 'Presumably,': [1590, 3351, 4546], 'due': [1593, 3354, 4549], 'inability': [1596, 3357, 4552], 'interact': [1600, 3361, 4556], 'hypothesis': [1609, 3370, 4565], 'supported': [1612, 1928, 3373, 3689, 4568, 4885], 'data': [1615, 1752, 2135, 3376, 3513, 3896, 4571, 4709, 5094], 'inhibition': [1618, 3379, 4574], 'prevents': [1622, 3383, 4578], 'interacting': [1625, 3386, 4581], 'homologue.': [1631, 3392, 4587], 'The': [1632, 1784, 1974, 2003, 3393, 3545, 3735, 3764, 4588, 4741, 4931, 4960], 'association': [1633, 3394, 4589], 'suggests': [1641, 1984, 3402, 3745, 4597, 4941], 'serves': [1645, 3406, 4601], 'scaffold': [1648, 3409, 4604], 'types,': [1658, 3419, 4614], 'sites': [1661, 1873, 3422, 3634, 4617, 4830], 'include': [1664, 3425, 4620], 'endoplasmic': [1666, 1697, 3427, 3458, 4622, 4653], 'reticulum': [1667, 1698, 3428, 3459, 4623, 4654], '(22Hovland': [1671, 3432, 4627], 'Hesketh': [1673, 3434, 4629], 'J.E.': [1674, 1902, 1951, 3435, 3663, 3712, 4630, 4859, 4908], 'Pryme': [1675, 3436, 4631], 'I.F.': [1676, 3437, 4632], 'Int.': [1677, 3438, 4633], '1996;': [1682, 3443, 4638], '28:': [1683, 3444, 4639], '1089-1105Crossref': [1684, 3445, 4640], '(58)': [1687, 3448, 4643], 'mature': [1691, 3452, 4647], '(23Kieffer': [1699, 3460, 4655], 'Guichard': [1701, 3462, 4657], 'Farcet': [1703, 3464, 4659], 'J.P.': [1704, 3465, 4660], 'Vainchenker': [1705, 3466, 4661], 'W.': [1706, 3467, 4662], 'Breton-Gorius': [1707, 3468, 4663], 'Eur.': [1709, 3470, 4665], '1987;': [1712, 3473, 4668], '164:': [1713, 3474, 4669], '189-195Crossref': [1714, 3475, 4670], '(180)': [1717, 3478, 4673], "24Ts'ao": [1720, 3481, 4676], 'C.H.': [1721, 3482, 4677], 'Scand.': [1722, 3483, 4678], 'Haematol.': [1724, 3485, 4680], '8:': [1726, 3487, 4682], '134-140Crossref': [1727, 3488, 4683], '(38)': [1730, 3491, 4686], 'network,': [1735, 3496, 4691], 'extensive': [1738, 3499, 4694], 'logical': [1743, 3504, 4699], 'site': [1744, 3505, 4700], 'translation.Although': [1747, 3508], 'considered,': [1750, 3511, 4707], 'mechanism': [1764, 3525, 4721], 'function.': [1768, 2838, 3529, 4725], 'topographically': [1774, 3535, 4731], 'skeleton.': [1783, 3544, 4740], 'lattice-like': [1789, 3550, 4746], 'coats': [1792, 3553, 4749], 'cytoplasmic': [1794, 3555, 4751], 'face': [1795, 3556, 4752], 'plasma': [1798, 3559, 4755], 'membrane.': [1799, 3560, 4756], 'It': [1800, 1829, 1885, 3561, 3590, 3646, 4757, 4786, 4842], 'composed': [1802, 3563, 4759], 'short': [1804, 3565, 4761], 'filaments,': [1806, 3567, 4763], 'actin-binding': [1807, 3568, 4764], 'proteins,': [1808, 3569, 4765], 'spectrin,': [1809, 3570, 4766], 'and,': [1810, 3571, 4767], 'vinculin': [1811, 3572, 4768], '(17Fox': [1812, 1837, 3573, 3598, 4769, 4794], 'J.E.B.': [1813, 1838, 3574, 3599, 4770, 4795], 'Watson': [1814, 1839, 3575, 3600, 4771, 4796], 'S.P.': [1815, 1840, 3576, 3601, 4772, 4797], 'Authi': [1816, 1841, 3577, 3602, 4773, 4798], 'K.S.': [1817, 1842, 3578, 3603, 4774, 4799], 'Platelets:': [1818, 1843, 3579, 3604, 4775, 4800], 'Practical': [1820, 1845, 3581, 3606, 4777, 4802], 'Approach.': [1821, 1846, 3582, 3607, 4778, 4803], 'Oxford': [1822, 1847, 3583, 3608, 4779, 4804], 'University': [1823, 1848, 3584, 3609, 4780, 4805], 'Press,': [1824, 1849, 3585, 3610, 4781, 4806], 'Oxford,': [1825, 1850, 3586, 3611, 4782, 4807], 'UK1996:': [1826, 1851, 3587, 3612, 4783, 4808], '217-233Google': [1827, 1852, 3588, 3613, 4784, 4809], 'contains': [1831, 3592, 4788], 'GPIb-IX,': [1832, 3593, 4789], 'α2β1': [1833, 3594, 4790], '(GPIa-IIa),': [1834, 3595, 4791], 'Association': [1854, 3615, 4811], 'allows': [1859, 3620, 4816], 'molecules': [1862, 1871, 3623, 3632, 4819, 4828], 'play': [1864, 3625, 4821], 'integrin-cytoskeletal': [1875, 3636, 4832], 'junctions': [1876, 3637, 4833], 'mediate': [1879, 3640, 4836], 'signal': [1880, 3641, 4837], 'transduction': [1881, 3642, 4838], 'events': [1882, 3643, 4839], 'believed': [1888, 3649, 4845], 'skeletal': [1896, 3657, 4853], '(11Fox': [1901, 1950, 3662, 3711, 4858, 4907], 'Lipfert': [1903, 1952, 3664, 3713, 4860, 4909], 'Clark': [1905, 1954, 3666, 3715, 4862, 4911], 'E.A.': [1906, 1955, 3667, 3716, 4863, 4912], 'Reynolds': [1907, 1956, 3668, 3717, 4864, 4913], 'C.C.': [1908, 1957, 3669, 3718, 4865, 4914], 'Austin': [1909, 1958, 3670, 3719, 4866, 4915], 'C.D.': [1910, 1959, 3671, 3720, 4867, 4916], 'Brugge': [1911, 1960, 3672, 3721, 4868, 4917], 'J.S.': [1912, 1961, 3673, 3722, 4869, 4918], 'Chem.': [1915, 1964, 3676, 3725, 4872, 4921], '1993;': [1916, 1965, 3677, 3726, 4873, 4922], '268:': [1917, 1966, 3678, 3727, 4874, 4923], '25973-25984Abstract': [1918, 1967, 3679, 3728, 4875, 4924], 'This': [1925, 3686, 4882], 'notion': [1926, 3687, 4883], 'Glanzmann': [1934, 3695, 4891], 'thrombasthenic': [1935, 3696, 4892], 'patients': [1936, 3697, 4893], 'effectively': [1939, 3700, 4896], 'redistribute': [1940, 3701, 4897], 'response': [1947, 3708, 4904], 'finding': [1975, 3736, 4932], 'ideally': [1988, 3749, 4945], 'positioned': [1989, 3750, 4946], 'communication': [1991, 3752, 4948], 'transmembrane': [1993, 3754, 4950], 'spanning': [1994, 3755, 4951], 'including': [1996, 3757, 4953], 'receptors.': [2002, 3763, 4959], 'proximity': [2004, 3765, 4961], 'receptors': [2009, 3770, 4966], 'may': [2010, 2217, 2263, 3771, 3978, 4024, 4967, 5176, 5222], 'facilitate': [2012, 3773, 4969], 'phosphorylation': [2014, 2082, 2119, 3775, 3843, 3880, 4971, 5040, 5077], '1': [2020, 3781, 4977], 'min': [2021, 3782, 4978], 'poststimulation.Tight': [2023, 3784], 'surprising': [2031, 3792, 4989], 'since': [2032, 3793, 4990], 'Extracellular': [2062, 3823, 5020], 'stimuli,': [2063, 3824, 5021], 'such': [2064, 3825, 5022], 'hormones,': [2066, 3827, 5024], 'factors,': [2068, 3829, 5026], 'mitogens': [2070, 3831, 5028], 'augment': [2071, 3832, 5029], 'increasing': [2075, 3836, 5033], 'transcription': [2077, 2242, 3838, 4003, 5035, 5201], 'protein,': [2088, 3849, 5046], '4E-BP1.': [2089, 3850, 5047], 'p38': [2092, 3853, 5050], 'mitogen-activated': [2093, 3854, 5051], 'kinase': [2095, 3856, 5053], 'mTOR-dependent': [2097, 3858, 5055], 'inhibit': [2099, 3860, 5057], '4E-BP1': [2102, 3863, 5060], 'respectively.': [2104, 3865, 5062], 'Under': [2105, 3866, 5063], 'conditions': [2107, 3868, 5065], 'studies,': [2110, 3871, 5068], 'interruption': [2111, 3872, 5069], 'does': [2115, 3876, 5073], 'alter': [2117, 3878, 5075], 'thrombin-induced': [2118, 3879, 5076], 'checkpoints.Our': [2134, 3895], 'new': [2137, 3898, 5096], 'αIIbβ3integrins': [2140, 3901, 5099], 'Inhibition': [2154, 3915, 5113], 'subsequent': [2159, 3920, 5118], 'Scholar)': [2213, 3974, 5172], 'antagonists': [2216, 3977, 5175], 'partially': [2218, 3979, 5177], 'explain': [2219, 3980, 5178], 'their': [2220, 3981, 5179, 5250], 'clinical': [2221, 3982, 5180], 'efficacy': [2222, 3983, 5181], 'reducing': [2224, 3985, 5183], 'severity': [2226, 3987, 5185], 'arterial': [2228, 3989, 5187], 'restenosis': [2229, 3990, 5188], 'cardiovascular': [2232, 3993, 5191], 'Spatial': [2256, 4017, 5215], 'well.': [2271, 4032, 5230], 'level.': [2615], 'DISCUSSIONTranslation': [2839], 'We': [4217, 5231], 'poststimulation.': [4980], 'Tight': [4981], 'checkpoints.': [5092], 'grateful': [5233], 'Guy': [5235], 'colleagues': [5240], 'Human': [5243], 'Molecular': [5244], 'Biology': [5245], 'Genetics': [5247], 'Program': [5248], 'helpful': [5251], 'comments': [5252], 'reading': [5255], 'manuscript.': [5258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054541525', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T05:00:37.582755', 'created_date': '2016-06-24'}
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