Title: Identification of a Unique Nuclear Receptor for 9-Cis Retinoic Acid
Abstract:Two families of nuclear receptors (RAR and RXR) for retinoic acid have previously been identified, cloned, and shown to be intimately involved with receptor-mediated regulation of gene transcription. ...Two families of nuclear receptors (RAR and RXR) for retinoic acid have previously been identified, cloned, and shown to be intimately involved with receptor-mediated regulation of gene transcription. All-trans-retinoic acid (t-RA) has been known to be a high-affinity ligand for RAR but only a weak ligand for RXR, while the endogenous ligand for RXR was unknown. Now two laboratories have isolated and chemically characterized 9-cis-retinoic acid (c-RA) and have shown that it is a naturally occurring ligand for RXR. These results suggest that isomerization of t-RA into c-RA may play an important role in retinoic acid biology.Read More
Publication Year: 2009
Publication Date: 2009-04-27
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 8
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