MicroRNA (miRNA) Transcriptome of Mouse Retina and Identification of a Sensory Organ-specific miRNA Cluster

Name: Work Video:
Duration: 3 min 30 s
Shunbin Xu; P. Dane Witmer; Stephen Lumayag; Beatrix Kovacs; David Valle
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4103, 4128, 4180, 4236, 4246, 4310, 4344], 'regulation': [9, 187, 261, 439, 650, 1199, 2149, 3643], 'gene': [11, 263, 652, 1388, 2151, 2908], 'expression,': [12, 264, 3270], 'the': [13, 17, 20, 36, 162, 189, 220, 245, 265, 269, 272, 288, 414, 441, 472, 497, 563, 713, 786, 794, 816, 821, 847, 863, 921, 929, 980, 1007, 1190, 1251, 1318, 1339, 1343, 1361, 1365, 1426, 1908, 2034, 2048, 2052, 2083, 2086, 2108, 2145, 2205, 2211, 2224, 2283, 2323, 2374, 2394, 2436, 2529, 2600, 2603, 2606, 2610, 2617, 2644, 2655, 2660, 2668, 2673, 2698, 2714, 2722, 2728, 2754, 2759, 2775, 2780, 2790, 2815, 2826, 2830, 2838, 2848, 2861, 2868, 2871, 2886, 2895, 2898, 2902, 2916, 2926, 2970, 2983, 2998, 3011, 3024, 3037, 3044, 3144, 3178, 3185, 3191, 3235, 3242, 3258, 3261, 3264, 3302, 3306, 3344, 3352, 3396, 3434, 3474, 3482, 3527, 3544, 3588, 3645, 3653, 3721, 3739, 3746, 3784, 3788, 3870, 3890, 3897, 3915, 3992, 3999, 4004, 4030, 4063, 4068, 4106, 4129, 4154, 4157, 4165, 4181, 4247, 4266, 4279], 'miRNA': [14, 44, 86, 193, 266, 296, 338, 445, 557, 970, 1063, 1081, 1198, 1247, 1694, 1776, 1844, 1897, 2025, 2035, 2045, 2352, 2531, 2622, 2633, 2662, 2674, 2724, 2729, 2755, 2907, 3017, 3049, 3083, 3158, 3188, 3423, 3529, 3575, 3722, 4241], 'transcriptome': [15, 267], 'retina': [18, 270, 2062, 2231, 2375, 3611, 3688, 3716, 3726, 3761, 3772, 3774, 3836, 3860, 3948, 4137], 'and': [19, 27, 52, 92, 121, 142, 149, 164, 176, 205, 210, 234, 271, 279, 304, 344, 373, 394, 401, 416, 428, 457, 462, 486, 567, 570, 639, 674, 1105, 1430, 1603, 1647, 1698, 1854, 1915, 1917, 2027, 2104, 2116, 2148, 2155, 2163, 2208, 2236, 2296, 2322, 2364, 2373, 2379, 2422, 2451, 2461, 2547, 2560, 2613, 2626, 2635, 2666, 2700, 2750, 2766, 2785, 2795, 2800, 2995, 3004, 3043, 3080, 3088, 3110, 3142, 3161, 3175, 3197, 3215, 3237, 3287, 3320, 3324, 3342, 3429, 3452, 3470, 3505, 3523, 3558, 3581, 3601, 3682, 3696, 3705, 3712, 3744, 3756, 3806, 3817, 3819, 3839, 3852, 3908, 3919, 3941, 3962, 3969, 3982, 4029, 4037, 4049, 4053, 4058, 4126, 4170, 4186, 4193, 4197, 4208, 4221, 4223, 4254, 4272, 4286, 4301, 4326, 4331, 4335, 4362], 'contributions': [21, 273], 'miRNAs': [23, 39, 64, 130, 181, 275, 291, 316, 382, 433, 643, 660, 845, 868, 905, 961, 1096, 1136, 1383, 1421, 2059, 2081, 2113, 2200, 2228, 2243, 2266, 2736, 3591, 3608, 3633, 3640, 3693, 3703, 3743, 3799, 3884, 3932, 4006, 4070, 4131, 4151, 4182, 4203, 4230, 4313, 4346, 4370], 'to': [24, 34, 102, 179, 276, 286, 354, 431, 716, 806, 917, 965, 1004, 1098, 1153, 1194, 1197, 1249, 1346, 1385, 1691, 1849, 1902, 1907, 2222, 2654, 2671, 2788, 2837, 2976, 3165, 3241, 3256, 3298, 3427, 3481, 3560, 3979, 4008, 4146, 4153, 4316], 'retinal': [25, 119, 167, 197, 277, 371, 419, 449, 1059, 1077, 2297, 2331, 2441, 2463, 2477, 2690, 3206, 3338, 3656, 3926, 4020, 4159, 4167, 4174, 4250], 'development': [26, 137, 278, 389, 1429, 2207, 4085], 'function': [28, 280, 2209, 2866, 3892], 'are': [29, 65, 74, 115, 236, 281, 317, 326, 367, 488, 534, 661, 671, 706, 783, 797, 813, 1137, 1148, 1192, 1317, 2244, 2253, 2268, 3055, 3621, 3833, 3854, 3862, 3944, 3971, 3984, 4162, 4256, 4314, 4337], 'largely': [30, 282], 'unknown.': [31, 283], 'To': [32, 284, 2213], 'begin': [33, 285], 'understand': [35, 287, 2215], 'functions': [37, 289, 2026, 3648], 'in': [40, 47, 67, 117, 144, 150, 184, 226, 238, 292, 299, 319, 369, 396, 402, 436, 478, 490, 542, 545, 551, 562, 574, 846, 854, 862, 1425, 1696, 1781, 1787, 2023, 2061, 2114, 2197, 2204, 2229, 2246, 2258, 2271, 2282, 2310, 2381, 2550, 2616, 2753, 2809, 3117, 3354, 3398, 3415, 3498, 3592, 3610, 3623, 3649, 3662, 3666, 3674, 3687, 3710, 3737, 3745, 3760, 3764, 3778, 3800, 3835, 3858, 3865, 3889, 3903, 3914, 3924, 3947, 3956, 3973, 3977, 3989, 4014, 4135, 4265, 4274, 4294, 4321], 'retina,': [41, 50, 70, 190, 293, 302, 322, 442, 2249, 2259, 3599, 3804, 4015], 'we': [42, 79, 191, 294, 331, 443, 2218, 2527, 2541, 2703, 3009, 3103, 3133, 3199, 3271, 3550, 3586, 3844, 4016], 'compared': [43, 295, 2233, 3734, 4115], 'expression': [45, 134, 194, 227, 246, 297, 386, 446, 479, 498, 653, 1340, 1362, 1389, 1695, 1777, 1845, 1898, 2046, 2110, 2152, 2225, 2284, 3000, 3028, 3589, 3723, 3750, 3877, 3955, 4083, 4104, 4134, 4190, 4351], 'profiles': [46, 298], 'adult': [48, 68, 145, 300, 320, 397, 2247, 2336, 2543, 3336, 3859, 3917, 4090, 4136], 'mouse': [49, 69, 95, 301, 321, 347, 2053, 2118, 2230, 2248, 2408, 2467, 2473, 2535, 2545, 2689, 3205, 3337, 3598, 3825, 4018, 4262], 'brain,': [51, 303, 1351, 2413, 3600, 3805], 'heart': [53, 305, 2701, 3667, 3675, 3713], 'by': [54, 243, 306, 495, 663, 708, 788, 799, 911, 924, 983, 1102, 1151, 2366], 'microarray': [55, 307, 2220, 2681, 2707, 3584], 'analysis.': [56, 308], 'Our': [57, 229, 309, 481], 'results': [58, 230, 310, 482], 'show': [59, 311], 'that': [60, 88, 110, 155, 232, 312, 340, 362, 407, 484, 670, 705, 782, 812, 927, 1349, 1369, 1381, 1420, 1843, 2267, 2526, 3707, 3730, 3829, 3846, 3882, 3943, 4149, 4228, 4367], 'at': [61, 200, 313, 452, 553, 2240, 2318, 2326, 2342, 2445, 2693, 2774, 2792, 3041, 3046, 3209, 3227, 3388, 3411, 3490, 3566, 3605, 3986, 4027, 4035, 4087, 4098, 4105, 4139, 4191, 4214], 'least': [62, 314, 554, 2241, 3567, 3606, 4099, 4140], '78': [63, 315, 2242, 3607], 'expressed': [66, 116, 318, 368, 2245, 2254, 2270, 3609, 3622, 3632, 3661, 3673, 3709, 3759, 3834, 3857, 3902, 3946, 3972, 3985, 4013, 4249], '21': [71, 323, 2250, 3683, 4005], 'which': [73, 325, 2252], 'potentially': [75, 182, 327, 434], 'retina-specific.': [76, 328], 'Among': [77, 329], 'these,': [78, 330, 3618, 4095], 'identified': [80, 211, 332, 463, 3056, 3604, 3701], 'polycistronic,': [82, 334], 'sensory': [83, 335, 1539], 'organ-specific': [84, 336], 'paralogous': [85, 337, 2265, 4373], 'cluster': [87, 114, 222, 339, 366, 474, 2262, 4374], 'includes': [89, 341], 'miR-96,': [90, 342, 3198, 3847, 4253, 4300], 'miR-182,': [91, 343, 3848, 4120, 4255], 'miR-183': [93, 345, 4336], 'on': [94, 346, 2044, 2317, 2948, 2982, 3146, 3195, 3268, 3330, 4261], 'chromosome': [96, 104, 348, 356], '6qA3': [97, 349], 'with': [98, 125, 138, 196, 223, 350, 377, 390, 448, 475, 593, 857, 908, 972, 1000, 1139, 1245, 2234, 2315, 2359, 2388, 2675, 2683, 2709, 2957, 3051, 3123, 3177, 3280, 3293, 3347, 3502, 3508, 3534, 3735, 3878, 3951, 4084, 4116, 4132, 4329], 'conservation': [99, 351], 'synteny': [101, 353], 'human': [103, 355, 1185, 1788], '7q32.2.': [105, 357], 'In': [106, 358, 793, 903, 1372, 2997, 3308, 4062], 'situ': [107, 359], 'hybridization': [108, 360, 1152, 2980, 3355, 3402], 'showed': [109, 154, 361, 406, 4078, 4097, 4138, 4188, 4210], 'members': [111, 218, 363, 470], 'this': [113, 365, 2021], 'photoreceptors,': [118, 370], 'bipolar': [120, 372], 'amacrine': [122, 374], 'cells.': [123, 375], 'Consistent': [124, 376], 'their': [126, 378, 549, 866, 966, 3749], 'genomic': [127, 379], 'organization,': [128, 380], 'these': [129, 381, 2216, 2288, 3883, 4150, 4229, 4311, 4345, 4368], 'have': [131, 383, 559, 962, 1688, 1778, 3921, 4071, 4232, 4303, 4347], 'similar': [133, 385, 4304, 4315, 4349], 'pattern': [135, 387, 1434, 2226, 3724, 4080, 4352, 4365], 'during': [136, 388], 'abundance': [139, 391], 'increasing': [140, 392, 1840, 4082], 'postnatally': [141, 393], 'peaking': [143, 395, 4086], 'retina.': [146, 398, 2039, 2212, 3894, 3980], 'Target': [147, 399], 'prediction': [148, 400], 'vitro': [151, 403], 'functional': [152, 404, 1909], 'studies': [153, 405, 1418, 3194], 'MITF,': [156, 408], 'transcription': [158, 410, 1068, 1086], 'factor': [159, 411], 'required': [160, 412], 'for': [161, 413, 1320, 2279, 2397, 2594, 2727, 2762, 2822, 2905, 2919, 2950, 3015, 3127, 3305, 3317, 3385, 3404, 3450, 3468, 3471, 3571, 3642, 3795, 4244], 'establishment': [163, 415], 'maintenance': [165, 417, 1604], 'pigmented': [168, 420, 511, 525, 1060, 1078], 'epithelium,': [169, 421], 'is': [170, 422, 824, 1900, 2031, 2141, 2193, 3900, 4296], 'direct': [172, 424], 'target': [173, 425, 858, 909, 922, 968, 1315, 3448, 3466], 'miR-96': [175, 233, 427, 485, 3238, 3451, 3469, 4323], 'miR-182.': [177, 429], 'Additionally,': [178, 430], 'identify': [180, 432, 2954], 'involved': [183, 237, 435, 489], 'circadian': [185, 239, 437, 491, 2280, 2437, 3192, 3265], 'rhythm': [186, 240, 438, 492, 2438, 3193, 3266], 'performed': [192, 444, 2678, 2704, 3565, 3791, 4054], 'profiling': [195, 447, 1846, 1899], 'RNA': [198, 450, 664, 930, 1156, 1984, 2291, 2332, 2403, 2410, 2442, 2464, 2478, 2488, 2539, 2629, 2640, 2646, 2691, 2716, 3007, 3109, 3207, 3218, 3245, 3596, 3801, 3866, 4021], 'harvested': [199, 451], 'noon': [201, 453], '(Zeitgeber': [202, 207, 454, 459], 'time': [203, 208, 455, 460, 1065, 1083, 2455, 3099, 3115, 3229, 4001, 4108, 4155], '5)': [204, 456], 'midnight': [206, 458], '17)': [209, 461], 'subgroup': [213, 465], '12': [215, 467, 3658, 4130], 'miRNAs,': [216, 468, 3657, 3898, 4251], 'including': [217, 469, 1432, 2260], 'miR-183/96/182': [221, 473], 'diurnal': [224, 476], 'variation': [225, 477], 'pattern.': [228, 480], 'suggest': [231, 483, 1419, 4366], 'miR-182': [235, 487, 3196, 3236, 4302, 4330, 4334], 'regulation,': [241, 493], 'perhaps': [242, 494], 'modulating': [244, 496], 'adenylyl': [248, 500], 'cyclase': [249, 501], 'VI': [250, 502], '(ADCY6).': [251, 503], 'MicroRNAs': [504], '3The': [506, 520], 'abbreviations': [507, 521], 'used': [508, 522, 1690, 2219, 2528, 2659, 2721, 2769, 3089, 3104, 3134, 3154, 3248, 3288, 3325], 'are:': [509, 523], 'miRNAmicroRNARPEretinal': [510, 524], 'epitheliumpri-miRNAprimary': [512, 526], 'miRNAZTZeitgeber': [513, 527], 'timeqRTquantitative': [514, 528], 'reverse': [515, 529, 1067, 1085], 'transcriptionEembryonic': [516, 530], 'dayPpostnatal': [517, 531], 'dayUTRuntranslated': [518, 532], 'regionntnucleotide': [519, 533], 'small,': [535], 'noncoding,': [536], 'regulatory': [537, 1322], 'RNAs': [538], '18–24': [540], 'nucleotides': [541], 'length': [543], 'found': [544, 3845, 3930], 'all': [546, 2747, 2875, 2890, 2944, 3624, 3650, 3796, 3830, 3855, 4066], 'metazoans.': [547], 'Since': [548], 'discovery': [550], '1993,': [552], '100': [555, 1376], 'different': [556], 'genes': [558, 1186, 1256, 3050, 4243, 4280], 'been': [560, 1689, 1779], 'documented': [561], 'genomes': [564, 576], 'Drosophila': [566], 'Caenorhabditis': [568], 'elegans': [569], 'more': [571, 1850, 3727], 'than': [572, 974, 2855], '250': [573], 'vertebrate': [575], '(1Bartel': [577, 725, 869], 'D.P.': [578, 726, 870, 944, 1044, 1172, 1230, 1297, 1403, 1590], 'Cell.': [579, 727, 871, 889, 945, 1231, 1300, 1442, 1460, 1487, 1566, 1633, 2515], '2004;': [580, 692, 728, 872, 990, 1554, 1592, 1760, 1831, 2517], '116:': [581, 729, 873], '281-297Abstract': [582, 730, 874], 'Full': [583, 585, 731, 733, 875, 877, 893, 895, 949, 951, 1125, 1127, 1235, 1237, 1304, 1306, 1446, 1464, 1491, 1493, 1529, 1531, 1570, 1572, 1637, 1639, 1763, 1765], 'Text': [584, 586, 732, 734, 876, 878, 894, 896, 950, 952, 1126, 1128, 1236, 1238, 1305, 1307, 1447, 1465, 1492, 1494, 1530, 1532, 1571, 1573, 1638, 1640, 1764, 1766], 'PDF': [587, 735, 879, 897, 953, 1129, 1239, 1308, 1448, 1466, 1495, 1533, 1574, 1641, 1767], 'PubMed': [588, 631, 695, 736, 756, 777, 838, 880, 898, 954, 993, 1026, 1053, 1130, 1178, 1220, 1240, 1285, 1309, 1412, 1449, 1467, 1496, 1511, 1534, 1557, 1575, 1595, 1621, 1642, 1682, 1722, 1768, 1834, 1890, 1953, 1969, 2001, 2015, 2135, 2187, 2520, 2589], 'Scopus': [589, 632, 696, 737, 757, 778, 839, 881, 899, 955, 994, 1027, 1054, 1131, 1179, 1221, 1241, 1286, 1310, 1413, 1450, 1468, 1497, 1535, 1558, 1576, 1596, 1622, 1643, 1683, 1723, 1769, 1835, 1891, 1954, 1970, 2002, 2016, 2136, 2188, 2521, 2590], '(26540)': [590, 738, 882], 'Google': [591, 634, 698, 739, 759, 780, 841, 883, 901, 957, 996, 1029, 1056, 1133, 1181, 1223, 1243, 1288, 1312, 1415, 1452, 1470, 1499, 1512, 1537, 1560, 1578, 1598, 1624, 1645, 1685, 1725, 1771, 1837, 1893, 1956, 1972, 2004, 2018, 2074, 2102, 2138, 2190, 2523, 2592], 'Scholar)': [592, 781, 1244, 1838, 2524, 2593], 'recent': [594, 2041], 'estimates': [595], 'as': [596, 598, 667, 723, 2196, 2232, 2481, 2491, 2630, 2738, 2825, 2857, 2864, 2915, 2929, 2961, 2965, 3018, 3057, 3093, 3184, 3733, 4039, 4041, 4172, 4319], 'high': [597, 3148, 3874], '800': [599], '(2Bentwich': [600], 'I.': [601, 1273, 1439, 2123, 2577], 'Avniel': [602], 'A.': [603, 613, 773, 1022, 1038, 1113, 1164, 1258, 1397, 1482, 1663, 1805, 1830, 1871, 1934, 2183], 'Karov': [604], 'Y.': [605, 623, 677, 742, 762, 1011, 1740, 2497, 2571], 'Aharonov': [606], 'R.': [607, 764, 1013, 1111, 1264, 1746, 1756], 'Gilad': [608], 'S.': [609, 685, 748, 772, 1021, 1166, 1543, 1550, 1742, 1807, 1829, 2127, 2182, 2495], 'Barad': [610], 'O.': [611, 1552], 'Barzilai': [612], 'Einat': [614], 'P.': [615, 1036, 1270, 1395, 1517], 'Einav': [616], 'U.': [617, 771, 1020, 1828, 2181], 'Meiri': [618], 'E.': [619, 621, 827, 1657, 1732, 1734, 1865, 1928, 2089, 2509, 2575], 'Sharon': [620], 'Spector': [622], 'Bentwich': [624], 'Z.': [625], 'Nat.': [626, 1280, 1717, 1964], 'Genet.': [627, 1281, 1718, 1965], '2005;': [628, 890, 1050, 1217, 1232, 1282, 1409, 1567, 1618, 1679, 1887, 1950, 1998, 2586], '37:': [629, 1283], '766-770Crossref': [630], '(1487)': [633], 'Scholar).': [635, 699, 842, 902, 958, 1057, 1134, 1182, 1313, 1416, 1686, 1772, 1894, 2019, 2139, 2191], 'By': [636], 'influencing': [637], 'translation': [638, 978], 'stability': [640], 'mRNAs,': [642], 'contribute': [644, 1848], 'affecting': [654], 'variety': [656], 'biological': [658], 'processes.': [659], 'transcribed': [662, 4264], 'polymerase': [665], 'II': [666], 'transcripts': [668, 1253], '(pri-miRNAs)': [669], 'capped,': [672], 'polyadenylated,': [673], 'spliced': [675], '(3Lee': [676], 'Kim': [678, 688, 747, 749], 'M.': [679, 1109, 1215, 1277, 1521, 1797, 1803, 1809, 1821, 1963, 2066, 2121, 2174], 'Han': [680], 'J.': [681, 691, 752, 1042, 1115, 1203, 1401, 1478, 1651, 1659, 1757, 1859, 1867, 1922, 1930, 1959, 1996, 2584], 'Yeom': [682], 'K.H.': [683], 'Lee': [684, 745], 'Baek': [686], 'S.H.': [687], 'V.N.': [689, 750], 'EMBO': [690, 751], '23:': [693], '4051-4060Crossref': [694], '(2932)': [697], 'pri-miRNAs': [700], 'fold': [701, 3012], 'into': [702, 815, 1335, 3473, 4164], 'hairpin': [703], 'structures': [704], 'cleaved': [707, 798], 'an': [709, 789, 984, 1140, 1330, 3111, 4275], 'RNase': [710, 802], 'III': [711, 803], 'endonuclease,': [712, 804], 'Drosha-DGCR8': [714], 'complex,': [715], 'form': [717], '60–70-nt': [718], 'stem': [719, 1600], 'loop': [720], 'intermediates': [721], 'known': [722, 2032], 'pre-miRNA': [724], 'Scholar,': [740, 760, 884, 1030, 1224, 1289, 1453, 1500, 1561, 1625, 1726, 1957, 1973, 1991, 2005], '4Lee': [741], 'Jeon': [743], 'K.': [744, 1211, 1504, 1612, 1981, 2094], 'J.T.': [746], '2002;': [753, 946, 1122, 1508], '21:': [754], '4663-4670Crossref': [755], '(1550)': [758], '5Zeng': [761], 'Yi': [763, 1012], 'Cullen': [765, 1014], 'B.R.': [766, 1015], 'Proc.': [767, 1016, 1824, 2177], 'Natl.': [768, 1017, 1825, 2178], 'Acad.': [769, 1018, 1826, 2179], 'Sci.': [770, 1019, 1827, 2131, 2180], '2003;': [774, 1023, 1175, 1301, 1488, 1526, 1634, 1988], '100:': [775, 1024], '9779-9784Crossref': [776, 1025], '(684)': [779, 1028], 'transported': [784], 'from': [785, 2082, 2303, 2335, 2412, 2433, 2465, 2643, 2687, 2713, 2718, 2973, 3086, 3220, 3322, 3597, 3803, 3867, 4022, 4042, 4144], 'nucleus': [787], 'Exportin': [790], '5-dependent': [791], 'mechanism.': [792], 'cytoplasm': [795], 'they': [796], 'second': [801], 'Dicer,': [805], 'yield': [807], 'double-stranded': [808], 'miRNA:': [809], 'miRNA*': [810, 822], 'duplexes': [811], 'loaded': [814], 'RNA-induced': [817, 850], 'silencing': [818, 851], 'complex': [819, 852], 'where': [820, 1839, 4298], 'strand': [823], 'degraded': [825], '(6Bernstein': [826], 'Caudy': [828], 'A.A.': [829, 1669, 1877, 1940], 'Hammond': [830, 1711], 'S.M.': [831, 1486, 1506, 1712, 1750], 'Hannon': [832], 'G.J.': [833], 'Nature.': [834, 989, 1049, 1216, 1408, 1553, 1617, 1678, 1886, 1949], '2001;': [835], '409:': [836], '363-366Crossref': [837], '(3517)': [840], 'Mature,': [843], 'single-stranded': [844], 'context': [848], 'engage': [853], 'base': [855, 906], 'pairing': [856], 'sites,': [859], 'located': [860, 4273], 'typically': [861], '3′-UTR': [864, 3435], 'client': [867], '7Sontheimer': [885], 'E.J.': [886, 1205, 1268], 'Carthew': [887, 1564, 1613], 'R.W.': [888, 1565, 1614], '122:': [891], '9-12Abstract': [892], '(231)': [900], 'plants,': [904], 'pair': [907], 'mRNAs': [910, 923, 1009, 1377], 'precise': [912, 915, 1851], 'or': [913, 2256, 2346, 2695, 2964, 3454, 3516, 3531, 3766, 3869, 3949, 4011, 4073, 4089, 4110, 4216], 'nearly': [914], 'complementarity': [916], 'specify': [918], 'cleavage': [919, 1005], 'mechanism': [926, 986], 'involves': [928], 'interference': [931], 'machinery': [932], '(8Rhoades': [933], 'M.W.': [934, 1168, 1295], 'Reinhart': [935], 'B.J.': [936], 'Lim': [937], 'L.P.': [938, 1032, 1158, 1391], 'Burge': [939, 1169, 1227, 1298], 'C.B.': [940, 1170, 1228, 1299], 'Bartel': [941, 943, 1043, 1171, 1229, 1296, 1402, 1589], 'B.': [942, 1437, 1754], '110:': [947], '513-520Abstract': [948], '(1660)': [956], 'Most': [959, 4076], 'animal': [960], 'imperfect': [963], 'complementary': [964, 976, 1002], 'mRNA': [967, 982, 1252], 'sites.': [969], 'binding': [971, 999], 'less': [973, 2854], 'perfect': [975, 1001], 'inhibits': [977], 'targeted': [981], 'unknown': [985], '(9Ambros': [987], 'V.': [988, 1209, 1459, 2125], '431:': [991], '350-355Crossref': [992], '(8241)': [995], 'Scholar),': [997, 1471, 1513, 1538, 1579, 1599, 1646, 2075, 2103], 'whereas': [998, 1146, 1352, 4201], 'leads': [1003], 'corresponding': [1008, 3186], '(5Zeng': [1010], '10Lim': [1031], 'Lau': [1033, 1159, 1392], 'N.C.': [1034, 1160, 1393], 'Garrett-Engele': [1035, 1394], 'Grimson': [1037, 1396], 'Schelter': [1039, 1398], 'J.M.': [1040, 1048, 1399, 1407, 1706], 'Castle': [1041, 1400], 'Linsley': [1045, 1404], 'P.S.': [1046, 1405], 'Johnson': [1047, 1406], '433:': [1051, 1410], '769-773Crossref': [1052, 1411], '(3747)': [1055, 1414], 'microRNA': [1058, 1076], 'epithelium': [1061, 1079, 2486, 2537, 2604, 2611], 'primary': [1062, 1080], 'Zeitgeber': [1064, 1082], 'quantitative': [1066, 1084, 3100, 3792], 'embryonic': [1069, 1087, 2115, 2423, 3820], 'day': [1070, 1072, 1088, 1090, 2424, 3002, 3821], 'postnatal': [1071, 1089, 2117, 4045], 'untranslated': [1073, 1091], 'region': [1074, 1092, 4293], 'nucleotide': [1075, 1093], 'Expression': [1094], 'appears': [1097], 'be': [1099, 1195, 4009], 'highly': [1100, 3856, 4248], 'regulated': [1101], 'developmental': [1103, 2165, 4000, 4350, 4364], 'stage': [1104], 'tissue': [1106], 'specificity': [1107, 3880], '(11Lagos-Quintana': [1108], 'Rauhut': [1110], 'Yalcin': [1112], 'Meyer': [1114], 'Lendeckel': [1116], 'W.': [1117, 2503], 'Tuschl': [1118], 'T.': [1119, 1673, 1881, 1944], 'Curr.': [1120, 1524], 'Biol.': [1121, 1525, 1758, 2516], '12:': [1123, 2072, 2100], '735-739Abstract': [1124], '(2568)': [1132], 'Some': [1135], 'abundant': [1138, 1331, 2060], 'estimated': [1141, 1193], '10,000': [1142], 'molecules': [1143], 'per': [1144], 'cell,': [1145], 'others': [1147], 'barely': [1149], 'detectable': [1150, 3864], 'total': [1154, 2402, 2409, 2440, 2462, 2487, 2538, 2628, 2645, 2715, 3108, 3204, 3595, 4019], 'cellular': [1155, 1912, 3647], '(12Lim': [1157], 'Weinstein': [1161], 'E.G.': [1162, 1736], 'Abdelhakim': [1163], 'Yekta': [1165], 'Rhoades': [1167], 'Genes': [1173], 'Dev.': [1174, 1632], '17:': [1176], '991-1008Crossref': [1177], '(933)': [1180], 'About': [1183], '5,000': [1184], '(∼': [1187], '20%': [1188], 'total)': [1191], 'subjected': [1196], '(13Xie': [1200], 'X.': [1201, 1563, 1730, 2172], 'Lu': [1202, 2572], 'Kulbokas': [1204], 'Golub': [1206, 1676, 1884, 1947], 'T.R.': [1207, 1677, 1885, 1948], 'Mootha': [1208], 'Lindblad-Toh': [1210], 'Lander': [1212], 'E.S.': [1213], 'Kellis': [1214], '434:': [1218], '338-345Crossref': [1219], '(1478)': [1222], '14Lewis': [1225], 'B.P.': [1226, 1291], '120:': [1233], '15-20Abstract': [1234], '(9149)': [1242], 'each': [1246, 1373, 2454, 2466, 2737, 2823, 2906, 2920, 3016, 3221, 3228, 3331, 3572], 'predicted': [1248], 'regulate': [1250], '∼200': [1255], '(15Krek': [1257], 'Grun': [1259], 'D.': [1260, 1661, 1869, 1932, 2176, 2513, 2581], 'Poy': [1261, 1960], 'M.N.': [1262, 1961], 'Wolf': [1263], 'Rosenberg': [1265], 'L.': [1266, 1586, 1815, 2501], 'Epstein': [1267], 'MacMenamin': [1269], 'da': [1271], 'Piedade': [1272], 'Gunsalus': [1274], 'K.C.': [1275], 'Stoffel': [1276, 1962], 'Rajewsky': [1278], 'N.': [1279, 1799, 1994], '495-500Crossref': [1284], '(3672)': [1287], '16Lewis': [1290], 'Shih': [1292], 'I.H.': [1293], 'Jones-Rhoades': [1294], '115:': [1302], '787-798Abstract': [1303], '(3904)': [1311], 'These': [1314, 3630], 'relationships': [1316], 'basis': [1319], 'major': [1321], 'effects': [1323], 'miRNAs.': [1325, 2289], 'For': [1326, 2435, 2534, 2697, 3097, 3129, 3190, 3263], 'example,': [1327], 'introduction': [1328, 1353], 'brain': [1332, 2235, 2699, 3663, 3678, 3711, 3732, 3765, 3868], 'miRNA,': [1333, 1358], 'miR-124,': [1334], 'HeLa': [1336], 'cells': [1337, 1345, 1367, 3489, 4161], 'causes': [1338], 'profile': [1341, 1363, 1692], 'recipient': [1344, 1366], 'shift': [1347], 'toward': [1348, 1368], 'prominent': [1356], 'muscle': [1357], 'miR-1,': [1359], 'shifts': [1360], 'muscle.': [1371], 'case,': [1374], 'about': [1375, 2033], 'were': [1378, 2301, 2308, 2357, 2371, 2431, 2459, 3225, 3408, 3659, 3672, 3684, 3708], 'down-regulated,': [1379], 'suggesting': [1380, 4148, 4227], 'tissue-specific': [1382, 1387], 'help': [1384], 'define': [1386], '(10Lim': [1390], 'Functional': [1417], 'play': [1422, 2201, 3886], 'important': [1423, 2202, 3641, 3887], 'roles': [1424, 2203, 3888], 'control': [1427, 3532], 'function,': [1431], 'temporal': [1433, 2162], 'formation': [1435], '(17Wightman': [1436], 'Ha': [1438], 'Ruvkun': [1440], 'G.': [1441, 1653, 1861, 1924], '1993;': [1443, 1461], '75:': [1444, 1462], '855-862Abstract': [1445], '(2829)': [1451], '18Lee': [1454], 'R.C.': [1455], 'Feinbaum': [1456], 'R.L.': [1457], 'Ambros': [1458], '843-854Abstract': [1463], '(8545)': [1469], 'cell': [1472, 1475, 1601, 4168], 'death': [1473], 'and/or': [1474, 4176], 'proliferation': [1476], '(19Brennecke': [1477], 'Hipfner': [1479], 'D.R.': [1480, 1502], 'Stark': [1481], 'Russell': [1483], 'R.B.': [1484], 'Cohen': [1485, 1505], '113:': [1489], '25-36Abstract': [1490], '(1612)': [1498], '20Hipfner': [1501], 'Weigmann': [1503], 'Genetics.': [1507], '161:': [1509], '1527-1537Crossref': [1510], 'fat': [1514], 'storage': [1515], '(21Xu': [1516], 'Vernooy': [1518], 'S.Y.': [1519], 'Guo': [1520], 'Hay': [1522], 'B.A.': [1523], '13:': [1527], '790-795Abstract': [1528], '(762)': [1536], 'neuron': [1540], 'specification': [1541], '(22Chang': [1542], 'Johnston': [1544], 'Jr.,': [1545], 'R.J.': [1546, 1744], 'Frokjaer-Jensen': [1547], 'C.': [1548, 1728, 1795], 'Lockery': [1549], 'Hobert': [1551], '430:': [1555], '785-789Crossref': [1556], '(278)': [1559], '23Li': [1562], '123:': [1568], '1267-1277Abstract': [1569], '(276)': [1577], 'hematopoietic': [1580], 'lineage': [1581], 'differentiation': [1582, 1700], '(24Chen': [1583], 'C.Z.': [1584, 1993], 'Li': [1585], 'Lodish': [1587], 'H.F.': [1588], 'Science.': [1591], '303:': [1593], '83-86Crossref': [1594], '(2608)': [1597], 'division': [1602], '(25Hatfield': [1605], 'S.D.': [1606, 2583], 'Shcherbata': [1607], 'H.R.': [1608, 1675, 1883, 1946], 'Fischer': [1609], 'K.A.': [1610], 'Nakahara': [1611], 'Ruohola-Baker': [1615], 'H.': [1616, 1813, 2499, 2507], '435:': [1619, 1680, 1888, 1951], '974-978Crossref': [1620], '(561)': [1623], '26Houbaviy': [1626], 'H.B.': [1627], 'Murray': [1628], 'M.F.': [1629], 'Sharp': [1630], 'P.A.': [1631, 2096], '5:': [1635], '351-358Abstract': [1636], '(915)': [1644], 'malignant': [1648], 'transformation': [1649], '(27Lu': [1650, 1858, 1921], 'Getz': [1652, 1860, 1923], 'Miska': [1654, 1862, 1925], 'E.A.': [1655, 1863, 1926], 'Alvarez-Saavedra': [1656, 1864, 1927], 'Lamb': [1658, 1866, 1929], 'Peck': [1660, 1868, 1931], 'Sweet-Cordero': [1662, 1870, 1933], 'Ebert': [1664, 1872, 1935], 'B.L.': [1665, 1873, 1936], 'Mak': [1666, 1874, 1937], 'R.H.': [1667, 1875, 1938], 'Ferrando': [1668, 1876, 1939], 'Downing': [1670, 1878, 1941], 'J.R.': [1671, 1879, 1942, 2091], 'Jacks': [1672, 1880, 1943], 'Horvitz': [1674, 1882, 1945], '834-838Crossref': [1681, 1889, 1952], '(7651)': [1684, 1892, 1955], 'Microarrays': [1687], 'normal': [1693, 2206, 3891], 'myoblast': [1697], 'preadipocyte': [1699], '(28Chen': [1701], 'J.F.': [1702], 'Mandel': [1703], 'E.M.': [1704], 'Thomson': [1705], 'Wu': [1707, 2580], 'Q.': [1708], 'Callis': [1709], 'T.E.': [1710], 'Conlon': [1713], 'F.L.': [1714], 'Wang': [1715, 2496], 'D.Z.': [1716], '2006;': [1719, 1966, 2012, 2071, 2099], '38:': [1720, 1967], '228-233Crossref': [1721], '(2010)': [1724], '29Esau': [1727], 'Kang': [1729], 'Peralta': [1731], 'Hanson': [1733], 'Marcusson': [1735], 'Ravichandran': [1737], 'L.V.': [1738], 'Sun': [1739], 'Koo': [1741], 'Perera': [1743], 'Jain': [1745], 'Dean': [1747], 'N.M.': [1748], 'Freier': [1749], 'Bennett': [1751], 'C.F.': [1752], 'Lollo': [1753], 'Griffey': [1755], 'Chem.': [1759], '279:': [1761], '52361-52365Abstract': [1762], '(809)': [1770], 'Abnormal': [1773], 'patterns': [1774], 'described': [1780, 2107, 2482, 2492, 2631], 'certain': [1782, 2286], 'disease': [1783, 1919, 2028], 'states,': [1784], 'most': [1785, 3990], 'notably': [1786], 'cancers': [1789], '(30Calin': [1790], 'G.A.': [1791, 2007], 'Liu': [1792], 'C.G.': [1793], 'Sevignani': [1794], 'Ferracin': [1796], 'Felli': [1798], 'Dumitru': [1800], 'C.D.': [1801], 'Shimizu': [1802], 'Cimmino': [1804], 'Zupo': [1806], 'Dono': [1808], "Dell'Aquila": [1810], 'M.L.': [1811], 'Alder': [1812], 'Rassenti': [1814], 'Kipps': [1816], 'T.J.': [1817], 'Bullrich': [1818], 'F.': [1819], 'Negrini': [1820], 'Croce': [1822, 2008], 'C.M.': [1823, 2009], '101:': [1832], '11755-11760Crossref': [1833], '(1108)': [1836], 'evidence': [1841, 2278], 'suggests': [1842, 3881], 'can': [1847], 'tumor': [1852], 'classification': [1853], 'predict': [1855], 'therapeutic': [1856], 'outcomes': [1857], 'Thus,': [1895], 'genome-wide': [1896], 'likely': [1901, 2194], 'become': [1903], 'powerful': [1905], 'addition': [1906, 3978], 'analysis': [1910, 2221, 2974, 3252], 'differentiation,': [1913], 'proliferation,': [1914], 'inherited': [1916], 'acquired': [1918], 'states': [1920], '31Krutzfeldt': [1958], '14-19Crossref': [1968], '(0)': [1971, 2137], '32Krichevsky': [1974], 'A.M.': [1975], 'King': [1976], 'K.S.': [1977, 1983, 2573], 'Donahue': [1978], 'C.P.': [1979, 2170], 'Khrapko': [1980], 'Kosik': [1982], '(Cold': [1985], 'Spring': [1986], 'Harbor).': [1987], '9:': [1989], '1274-1281Google': [1990], '33Chen': [1992], 'Engl.': [1995], 'Med.': [1997], '353:': [1999], '1768-1771Crossref': [2000], '(654)': [2003], '34Calin': [2006], 'Cancer': [2010], 'Res.': [2011], '66:': [2013], '7390-7394Crossref': [2014], '(890)': [2017], 'Despite': [2020], 'progress': [2022], 'understanding': [2024], 'associations,': [2029], 'little': [2030, 4072], 'complement': [2036], 'mammalian': [2038], 'One': [2040, 3895], 'report': [2042], 'focused': [2043], 'anterior': [2049], 'segment': [2050], 'eye': [2054, 2084, 2119, 4023], 'but': [2055, 3664, 3676, 3714, 3762, 3861, 3912], 'does': [2056], 'list': [2057], '10': [2058, 2425, 2595, 3105, 3201, 3370, 3823, 4050], '(35Ryan': [2063], 'D.G.': [2064], 'Oliveira-Fernandes': [2065], 'Lavker': [2067], 'R.M.': [2068], 'Mol.': [2069, 2097, 2514], 'Vis.': [2070, 2098, 2130], '1175-1184PubMed': [2073], 'another': [2076, 4318], 'reports': [2077], 'cloning': [2078], '9': [2080], 'newt': [2087], '(36Makarev': [2088], 'Spence': [2090], 'Del': [2092], 'Rio-Tsonis': [2093], 'Tsonis': [2095], '1386-1391PubMed': [2101], 'third': [2106], 'spatiotemporal': [2109], '7': [2112], '(37Karali': [2120], 'Peluso': [2122], 'Marigo': [2124], 'Banfi': [2126], 'Investig.': [2128], 'Ophthalmol.': [2129], '2007;': [2132], '48:': [2133], '509-515Crossref': [2134], 'Retina': [2140], 'derivative': [2143], 'forebrain': [2146], 'ectoderm,': [2147], 'through': [2153], 'intrinsic': [2154], 'extrinsic': [2156], 'factors': [2157], 'ensures': [2158], 'tightly': [2160], 'controlled': [2161], 'spatial': [2164], 'sequence': [2166, 3537, 4356], '(38Cepko': [2167], 'C.L.': [2168], 'Austin': [2169], 'Yang': [2171], 'Alexiades': [2173], 'Ezzeddine': [2175], '1996;': [2184], '93:': [2185], '589-595Crossref': [2186], '(790)': [2189], 'It': [2192], 'that,': [2195], 'other': [2198, 2272, 3808, 3871, 3916, 3958, 3975, 4202], 'tissues,': [2199], 'better': [2214], 'functions,': [2217], 'determine': [2223, 3257], 'heart.': [2237, 3602], 'We': [2238, 2275, 2597, 2608, 2658, 2677, 2720, 2757, 2828, 2851, 2859, 2893, 2922, 2953, 2968, 3022, 3153, 3247, 3300, 3333, 3350, 3391, 3486, 3564, 3603, 3699, 3827, 3928], 'find': [2239], 'preferentially': [2255, 3945, 4012], 'specifically': [2257, 4010], 'three': [2264, 2457, 2679, 2705, 2912, 3223, 3568, 3625, 4245, 4312, 4343, 4369], 'also': [2269, 2276, 2598, 3660, 3700, 3901, 3929], 'neurosensory': [2273], 'tissues.': [2274, 3651, 3872, 3993], 'present': [2277], 'cycling': [2281], 'Mouse': [2290, 2484, 3578], 'Samples—Wild': [2292], 'type': [2293], 'SVJ129': [2294, 2337, 2544], 'mice': [2295, 2338, 2430, 2458, 3224, 4052], 'degeneration': [2298], 'mice,': [2299], 'rd1,': [2300], 'purchased': [2302, 2432, 2717, 3061, 3311], 'The': [2304, 2369, 2804, 2811, 3048, 3231, 3406, 3574, 4291, 4308, 4355], 'Jackson': [2305], 'Laboratories.': [2306], 'Mice': [2307, 2356], 'kept': [2309], '12-h': [2311], 'light/12-h': [2312], 'dark': [2313], 'cycles': [2314], 'lights': [2316, 2324], '7:00': [2319, 2327], 'a.m.': [2320, 2348], '(ZT0)': [2321], 'off': [2325, 2612], 'p.m.': [2328, 2344], '(ZT12).': [2329], 'Total': [2330], 'was': [2333, 2376, 2404, 2443, 2468, 2479, 2489, 2807, 2820, 3239], 'prepared': [2334, 2469, 2480, 2490, 2627, 2711, 3208, 3334], '(∼3': [2339], 'months': [2340, 2475], 'old)': [2341, 2476], '12:00': [2343, 2347], '(ZT5)': [2345, 3003], '(ZT17)': [2349, 3006], 'using': [2350, 2648, 3029, 3539], 'mirVana': [2351, 2530, 2621, 2661, 2723, 3062, 3081], 'isolation': [2353, 2398, 2532, 2623], 'system': [2354, 2624, 3163, 3278], '(Ambion).': [2355, 2406], 'anesthetized': [2358], 'pentobarbital': [2360], '(75': [2361], 'mg/kg': [2362], 'intraperitoneally)': [2363], 'sacrificed': [2365], 'cervical': [2367], 'dislocation.': [2368], 'eyes': [2370], 'enucleated,': [2372], 'quickly': [2377], 'removed': [2378, 2542, 2969], 'submerged': [2380], '300': [2382, 3399], 'μl': [2383, 3400], 'lysis/binding': [2385], 'buffer,': [2386], 'homogenized': [2387], 'plastic': [2390], 'pestle': [2391], 'homogenizer.': [2392], 'Thereafter,': [2393], "manufacturer's": [2395, 2656, 3303, 3345], 'protocol': [2396, 2670, 2761, 3304, 3346], 'small': [2400, 2639, 3593], 'RNA-enriched': [2401, 3594], 'followed': [2405, 2667, 2758, 3301, 3343], 'Adult': [2407, 2471], 'samples': [2411, 2647, 3219], 'heart,': [2414, 3736], 'thymus,': [2415, 3811], 'lung,': [2416, 3812], 'liver,': [2417, 3813], 'spleen,': [2418, 3814], 'testicle,': [2419], 'ovary,': [2420], 'kidney,': [2421, 3815], 'embryos': [2426, 3905, 4026, 4034], 'Swiss': [2428], 'Webster': [2429], 'Ambion.': [2434, 2719], 'study,': [2439], 'isolated': [2444, 3802, 4017], 'ZT1,': [2446, 3210], 'ZT5,': [2447, 3211], 'ZT9,': [2448, 3212], 'ZT13,': [2449, 3213], 'ZT17,': [2450, 3214], 'ZT21.': [2452, 3216], 'At': [2453], 'point,': [2456], 'sacrificed,': [2460], 'separately.': [2470], 'rd1': [2472], '(∼4': [2474], 'above.': [2483, 2632], 'olfactory': [2485], 'previously': [2493], '(39Xu': [2494], 'Zhao': [2498], 'Zhang': [2500], 'Xiong': [2502], 'Yau': [2504], 'K.W.': [2505], 'Hiel': [2506], 'Glowatzki': [2508], 'Ryugo': [2510], 'D.K.': [2511], 'Valle': [2512], '24:': [2518], '9137-9151Crossref': [2519], '(13)': [2522], 'except': [2525, 3831], 'system.': [2533], 'tongue': [2536], 'preparation,': [2540], 'tongues': [2546], 'soaked': [2548, 2614], 'them': [2549, 3507, 3690], 'enzyme': [2551, 4288], 'mixture': [2552, 2601], '(1': [2553], 'mg/ml': [2554, 2562, 3381], 'collagenase': [2555], 'A': [2556], '(Sigma),': [2557], 'dispase': [2558], '(Invitrogen),': [2559], '1': [2561, 3386, 3695, 4047], 'trypsin': [2563], 'inhibitor': [2564], '(Roche': [2565], 'Applied': [2566], 'Science))': [2567], '(40Huang': [2568], 'Y.J.': [2569], 'Maruyama': [2570], 'Pereira': [2574], 'Plonsky': [2576], 'Baur': [2578], 'J.E.': [2579], 'Roper': [2582], 'Neurosci.': [2585], '25:': [2587], '843-847Crossref': [2588], '(150)': [2591], 'min.': [2596], 'injected': [2599], 'under': [2602], 'tongue.': [2607], 'peeled': [2609], 'it': [2615], 'lysis': [2618], 'buffer': [2619, 3356, 3403], '(Ambion)': [2625, 2652, 2665, 2726], 'Labeling': [2634], 'Microarray': [2636, 2764], 'Hybridization—We': [2637, 3310], 'purified': [2638], '(<40': [2641], 'nt)': [2642], 'FlashPAGE': [2650], 'fractionator': [2651], 'according': [2653, 2836], 'protocol.': [2657], 'labeling': [2663], 'kit': [2664, 3085, 3548], 'Ambion': [2669, 3087], 'label': [2672], 'Cy3.': [2676], 'independent': [2680, 2684, 2688, 2706, 2735, 2913, 3569], 'hybridizations': [2682, 2708, 3407], 'probes': [2685, 2712, 3316], 'labeled': [2686], 'preparations': [2692], 'ZT5': [2694, 3042], 'ZT17.': [2696, 3047], 'profiling,': [2702], 'independently': [2710], 'bioarray': [2725], 'profiling.': [2730], 'This': [2731, 3873], 'array': [2732, 2824, 2984], 'contains': [2733], '385': [2734], 'duplicate': [2740], 'feature,': [2741], 'representing': [2742], 'comprehensive': [2744], 'panel': [2745], 'human,': [2748], 'mouse,': [2749, 4322], 'rat': [2751], 'Registry.': [2756], "manufacturers'": [2760], 'hybridization.': [2763, 3405], 'Scanning': [2765], 'Data': [2767], 'Analysis—We': [2768], 'Packard': [2771], 'Biochip': [2772], 'scanner': [2773], 'Research': [2776], 'Resource': [2777], 'Center': [2778], 'University': [2781], 'Illinois,': [2783], 'Chicago,': [2784], 'ScanArray': [2786], 'software': [2787], 'scan': [2789], 'arrays': [2791], '90–95%': [2793], 'power': [2794], 'photomultiplier': [2797], '75–80': [2799], '5': [2801, 3090, 3243, 3367, 3494], 'μm': [2802], 'resolution.': [2803], 'spot': [2805, 2843], 'intensity': [2806, 2813, 2833, 2844, 2900, 3040], 'determined': [2808], 'QuantArray.': [2810], 'average': [2812, 2869, 2896], '“empty”': [2816], 'spots': [2817, 2904], '(negative': [2818], 'controls)': [2819], 'calculated': [2821, 2829, 2894, 2923, 3010], 'background.': [2827], 'background-corrected': [2831], 'signal': [2832, 2879, 2918, 2928, 2956, 3039], '(BgCor': [2834], 'Signal)': [2835], 'formula:': [2839], 'BgCor': [2840, 2862, 2872, 2881, 2887], 'Signal': [2841, 2863, 2873, 2882, 2888], '=': [2842, 2880, 2937, 2940], '-': [2845], '(average': [2846], 'empty': [2849], 'spots).': [2850], 'reported': [2852], 'values': [2853], 'zero': [2856], 'zero.': [2858], 'normalized': [2860, 2878, 2899, 2951, 3240, 3559], 'noncontrol': [2876, 2891, 2945], 'spots:': [2877], '×': [2883, 2911, 3495], '100/average': [2884], 'spots.': [2892], 'six': [2903], '(duplicate': [2909], 'spots/array': [2910], 'arrays)': [2914], 'specific': [2917, 2927, 3019, 3038], 'miRNA.': [2921], 'significance': [2924, 3025, 3259], 'two-tailed': [2931, 3031], 'p': [2932, 2958, 3052], 'value': [2933], 'Z-test': [2935], '(X': [2936], '0,': [2938], 'σ': [2939], 'standard': [2941], 'deviation': [2942], 'feature': [2946], 'signals': [2947], 'array)': [2949], 'signals.': [2952], '<': [2959, 3053], '0.01': [2960], '“positive”': [2963], '“expressed': [2966], 'miRNA.”': [2967], 'following': [2971], 'features': [2972], 'due': [2975], 'observation': [2977], 'apparent': [2979, 3879], 'artifacts': [2981], 'images:': [2985], 'BA10458,': [2986], 'BA10440,': [2987], 'BA10339,': [2988], 'BA10333,': [2989], 'BA10283,': [2990], 'BA10442,': [2991], 'BA10376,': [2992], 'BA10245,': [2993], 'BA10479,': [2994], 'BA10351.': [2996], 'differential': [2999, 3027], 'between': [3001, 3036, 4278], 'night': [3005], 'samples,': [3008, 4065], 'change': [3014], 'signal-ZT17/specific': [3020], 'signal-ZT5.': [3021], 'evaluated': [3023], 'pairwise': [3032], "Student's": [3033], 't': [3034], 'test': [3035, 3255], 'one': [3045, 4317], '0.1': [3054], 'differentially': [3058], 'expressed.': [3059], 'RT-PCR—We': [3060], 'qRT-PCR': [3063, 3082, 3162, 4055], 'primer': [3064, 3180, 3283, 3294], 'sets': [3065], 'mmu-miR-7,': [3067], 'mmu-miR-9,': [3068], 'mmu-miR-31,': [3069], 'mmu-miR-96,': [3070], 'mmu-miR-181c,': [3071], 'mmu-miR-182,': [3072, 3318], 'mmu-miR-185,': [3073], 'mmu-miR-194,': [3074], 'mmu-miR-210,': [3075], 'mmu-miR-219,': [3076], 'mmu-miR-320,': [3077], 'mmu-miR-335,': [3078], 'mmu-miR-361,': [3079], 'detection': [3084, 3315], 'S': [3091, 3244, 3290], 'rRNA': [3092, 3291], 'normalizing': [3095], 'control.': [3096], 'real': [3098, 3114], 'PCR': [3101], '(qPCR),': [3102], 'ng': [3106, 3202, 3510, 3519], 'Opticon': [3112], '2': [3113, 3121, 3755, 3838, 3907, 3961], 'detector': [3116], 'DNA': [3119, 3136], 'engine': [3120], '(Bio-Rad)': [3122], 'SYBR': [3124, 3156, 3275], 'Green': [3125, 3157, 3276], 'I': [3126], 'detection.': [3128], 'end': [3130], 'product': [3131, 3145], 'PCR,': [3132], 'Engine': [3137], 'Dyad': [3138], 'Peltier': [3139], 'thermal': [3140], 'cycler': [3141], 'separated': [3143], '3.5%': [3147], 'resolution': [3149], 'agarose': [3150], 'electro-phoresis': [3151], 'gel.': [3152], 'NCod': [3155], 'first-strand': [3159], 'synthesis': [3160], '(Invitrogen)': [3164], 'amplify': [3166, 3428], 'mmu-miR-9-AS,': [3167], 'mmu-miR-25,': [3168], 'mmu-miR-92,': [3169], 'mmu-miR-106b,': [3170], 'mmu-miR-183,': [3171, 3319], 'mmu-miR-184,': [3172], 'mmu-miR-211,': [3173], 'mmu-miR-140-AS,': [3174], 'rno-miR151-AS': [3176], 'forward': [3179], '(Sigma': [3181], 'Genosys)': [3182], 'sequences': [3183, 4309], 'mature': [3187, 4166, 4173], 'sequences.': [3189], 'amplified': [3200, 3226, 3292], 'Three': [3217], 'point.': [3230], 'relative': [3232], 'quantity': [3233], 'quantitation.': [3246], 'nonparametric': [3250], 'one-way': [3251], 'variance': [3254], 'differences.': [3262], 'study': [3267, 3998], 'Adcy6': [3269], 'employed': [3272], 'QuantiFast': [3274], 'RT-PCR': [3277, 3426, 3793], '(Qiagen)': [3279], 'Mm_Adcy6_1_SG': [3281], 'QuantiTect': [3282], 'set': [3284, 3295, 3637], '(Qiagen,': [3285, 3296], 'QT00136850)': [3286], '18': [3289], 'QT01036875)': [3297], 'normalize.': [3299], 'qRT-PCRs.': [3307], 'Situ': [3309], '5′-digoxigenin-labeled': [3312], 'miRCURY': [3313], 'LNA': [3314], 'mmu-miR-96': [3321], 'Exiqon': [3323], '∼6': [3326, 3393], 'pmol': [3327, 3394, 3525], 'probe': [3329, 3397], 'section.': [3332], 'fresh-frozen': [3335], 'sections': [3339, 3353], '(10': [3340], 'μm)': [3341], 'minor': [3348], 'modifications.': [3349], 'prehybridized': [3351], '(50%': [3357], 'formamide,': [3358], '0.3': [3359], 'm': [3360], 'NaCl,': [3361], '20': [3362], 'mm': [3363, 3368, 3371], 'Tris-HCl,': [3364], 'pH': [3365, 3373], '8.0,': [3366, 3374], 'EDTA,': [3369], 'NaPO4,': [3372], '10%': [3375], 'dextran': [3376], 'sulfate,': [3377], '1×': [3378], "Denhardt's,": [3379], '0.5': [3380], 'baker': [3382], 'yeast': [3383], 'RNA)': [3384], 'h': [3387, 3556], 'room': [3389], 'temperature.': [3390], 'diluted': [3392], 'carried': [3409], 'out': [3410], '52': [3412, 4325], '°C': [3413], 'overnight': [3414], 'humidified': [3417], 'chamber.': [3418], 'Luciferase': [3419], 'Reporter': [3420], 'Assays': [3421], 'Targeting—We': [3424], 'utilized': [3425], 'subclone': [3430], 'fragments': [3431], '(SpeI/HindIII)': [3432], 'ADCY6': [3437], '(nt': [3438, 3456], '4206–6520': [3439], 'GenBank™': [3441, 3459], 'accession': [3442, 3460], 'number': [3443, 3461, 3740], 'NM_015270,': [3444], 'containing': [3445, 3463], 'four': [3446, 3464], 'potential': [3447, 3465], 'sites': [3449, 3467], 'miR-182)': [3453, 3472], 'MITF': [3455], '3219–4654': [3457], 'NM_198159,': [3462], 'luciferase': [3475, 3484, 3546, 3553, 3562], 'reporter': [3476, 3513], 'vector,': [3477], 'pMIR-REPORT': [3478], '(Ambion),': [3479, 3585], '3′': [3480], 'firefly': [3483, 3552], 'cassette.': [3485], 'plated': [3487], 'HEK293': [3488], 'density': [3492], '105': [3496], 'cells/well': [3497], '24-well': [3499], 'plates': [3500], 'coated': [3501], 'poly-d-lysine': [3503], '(Sigma)': [3504], 'transfected': [3506], '150': [3509], 'pMIR': [3512], 'construct': [3514], '(pMIR-REPORT-3′-UTR/Adcy6': [3515], 'pMIR-REPORT-3′-UTR/Mitf),': [3517], '15': [3518], 'hpRL-SV40': [3521], '(Promega),': [3522, 3549], '5–10': [3524], 'specified': [3528], 'mimics': [3530], 'oligonucleotide': [3533], 'scrambled': [3536], '(Dharmacon)': [3538], 'Lipofectamine': [3540], '2000': [3541], '(Invitrogen).': [3542], 'Using': [3543], 'dual': [3545], 'assay': [3547], 'measured': [3551], 'activity': [3554], '48': [3555], 'later': [3557], 'Renilla': [3561], 'activity.': [3563], 'experiments': [3570], 'assay.': [3573], 'Transcriptomes': [3576], 'Retina,': [3579], 'Brain,': [3580], 'Heart—Using': [3582], 'profiled': [3587], '(Fig.': [3612, 3694, 3751, 3837, 3906, 3960, 4056, 4091, 4195, 4218, 4306, 4340, 4353], '1)': [3613], '(supplemental': [3614, 3627, 3668, 3679, 3717, 4112], 'Table': [3615, 3628, 3669, 3680, 3697, 3718, 4060, 4113, 4199, 4225], '1).': [3616, 3698, 3842, 3965], 'Of': [3617, 3652, 4094], '40': [3619], '(∼51%)': [3620], 'tissues': [3626, 3809, 3918, 3959, 3976], '8).': [3629], 'widely': [3631], 'may': [3634, 3885, 3920, 4231], 'represent': [3635], '“housekeeping”': [3639], 'basic': [3646], 'remaining': [3654], '38': [3655], 'not': [3665, 3677, 3715, 3763, 3863, 3913], '2A);': [3670], 'five': [3671], '2B);': [3681], 'detected': [3685], 'only': [3686], 'making': [3689], 'candidate': [3691], 'retina-specific': [3692, 3798], 'two': [3702], '(miR-143': [3704], 'Ambi_miR_7029)': [3706], '7).': [3719], 'Overall,': [3720], 'closely': [3728], 'resembled': [3729], 'both': [3738], 'shared': [3742, 4363], 'levels': [3747, 3953], '1,': [3752], 'supplemental': [3753, 3840, 3909, 3963, 4059, 4198, 4224], 'Tables': [3754], '8–10).TABLE': [3757], '1miRNAs': [3758], 'heartNo.Namems': [3767], 'chr': [3768, 3770], 'locationhs': [3769], 'locationAverage': [3771], '(ZT5)Average': [3773], '(ZT17)1hsa_miR_1826qA37q32.2693.9869.62hsa_miR_1836qA37q32.2491.7583.03hsa_miR_1849qE3.315q25.1401.5380.24mmu_miR_2117qC15q13.3391.4445.65hsa_miR_2107F511q15.5368.4443.06hsa_miR_966qA37q32.2368.3416.97hsa_miR_314qC49p21.3325.6303.58hsa_miR_181c8C319p13.12325.0233.69hsa_miR_3356qA37q32.2301.9181.010rno_miR_151_AS15qE1/10?8q24.3281.3254.611mmu_miR_140_AS8qD116q22.1273.2208.112hsa_miR_255qG17q22.1263.3116.013hsa_miR_361XqDXq21.2260.0255.814hsa_miR_32014qD18q21.3249.4305.515hsa_miR_21917qB2/2qA36p21.32/9q34.11193.2194.016hsa_miR_9214/XqA513q31.3/Xq26.2192.7188.317hsa_miR_1941qH4/19qA1q41/11q13.1189.1155.618hsa_miR_9_AS9qF1/13qC3/7qD21q23.1167.1109.319hsa_miR_713qB2/7qD2/17qD9q21.33140.9161.020hsa_miR_18516qB122q11.21119.0147.121hsa_miR_106b5qG17q22.157.4188.2': [3775], 'Open': [3776], 'table': [3777], 'new': [3780], 'tab': [3781], 'Confirmation': [3782], 'Tissue': [3785], 'Specificity': [3786], 'Retinal': [3789], 'miRNAs—We': [3790], 'assays': [3794], 'apparently': [3797], 'eight': [3807], '(heart,': [3810], 'testis,': [3816], 'ovary)': [3818], '(E)': [3822], 'whole': [3824], 'embryos.': [3826], 'confirmed': [3828], 'miR-361': [3832], 'Fig.': [3841, 3910, 3964], 'Interestingly,': [3843], 'miR-183,': [3849, 4252, 4332], 'miR-184,': [3850, 4123, 4206], 'miR-210,': [3851, 3899], 'miR-140-AS': [3853], 'E10': [3904, 4064], '1),': [3911], 'role': [3923], 'early': [3925], 'development.': [3927], 'nine': [3931], '(miR-7,': [3933], 'miR-9,': [3934], 'miR-9-AS,': [3935], 'miR-31,': [3936], 'miR-181c,': [3937], 'miR-211,': [3938, 4124, 4205], 'miR-219,': [3939, 4184], 'miR-320,': [3940], 'miR-335)': [3942], 'retina/brain': [3950], 'low': [3952, 3987], 'various': [3957], 'miR-25,': [3966, 4207], 'miR-92,': [3967], 'miR-194,': [3968, 4185], 'miR-151-AS': [3970], 'several': [3974], 'miR-106b': [3981], 'miR-185': [3983], 'Developmental': [3994], 'Patterns': [3995], 'Expression—To': [3997], 'course': [4002], 'shown': [4007], 'cups': [4024], 'E10,': [4028], 'developing': [4031], 'retinas': [4032, 4043], 'E14': [4036, 4192, 4215], 'E18,': [4038], 'well': [4040], 'days': [4046], '(P1)': [4048], '(P10)': [4051], '3': [4057], '13).': [4061], 'assayed': [4069], 'no': [4074], 'expression.': [4075], '(17/21)': [4077], 'P10': [4088], '3,': [4092, 4219], 'A–C).': [4093], '14': [4096], '10-fold': [4101, 4142], 'increase': [4102, 4143, 4213], 'peak': [4107, 4133, 4189], '(adult': [4109], 'P10)': [4111], '13),': [4114, 4200, 4226], 'E10.': [4117], 'Eight': [4118], '(miR-183,': [4119], 'mir-96,': [4121], 'miR-9_AS,': [4122], 'miR-151_AS,': [4125], 'miR-140_AS)': [4127, 4209], 'P1': [4145], 'adult,': [4147], 'correspond': [4152], 'when': [4156], 'late': [4158], 'progenitor': [4160], 'differentiating': [4163], 'types': [4169], 'functioning': [4171], 'neurons': [4175], 'Muller': [4177], 'glia.': [4178], 'Four': [4179], '(miR-335,': [4183], 'miR-185)': [4187], 'E18.5': [4194], '3D': [4196], '(miR-151_AS,': [4204], 'moderate': [4212], 'E18': [4217], 'B': [4220], 'C,': [4222], 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