Title: A Case of Pure Acinar Cell Carcinoma of the Pancreas Suggesting the Efficacy of the Gemcitabine Adjuvant Chemotherapy
Abstract: A 50-year-old man was admitted because of weight loss and aggravation of diabetes mellitus. Contrast-enhanced computed tomography demonstrated a low density tumor measuring 30 mm in diameter in the pancreas head. ERCP showed a smooth stenosis in the main pancreatic duct. EUS-guided biopsy of the tumor was performed, and it was diagnosed as islet cell tumor by the histopathological findings. During two months, the tumor doubled in size. Pancreaticoduodenectomy was performed. The diagnosis of the tumor was pure acinar cell carcinoma on the final histopathology by immunohistochemical staining (IHC) and electoron microscopy. The availability of preoperative diagnosis with IHC is considerable. The tumor markers were not decreased to the normal range in the postoperative course. Probably, this was caused by microscopical tumor persistence, whereas the patient was free of disease for 6 months with gemcitabine adjuvant chemotherapy.