Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2054155470', 'doi': 'https://doi.org/10.1016/s0952-3278(97)90531-7', 'title': 'Differential effects of cyclo-oxygenase pathway metabolites on cytokine production by T lymphocytes', 'display_name': 'Differential effects of cyclo-oxygenase pathway metabolites on cytokine production by T lymphocytes', 'publication_year': 1997, 'publication_date': '1997-03-01', 'ids': {'openalex': 'https://openalex.org/W2054155470', 'doi': 'https://doi.org/10.1016/s0952-3278(97)90531-7', 'mag': '2054155470', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9089795'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0952-3278(97)90531-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S9307485', 'display_name': 'Prostaglandins Leukotrienes and Essential Fatty Acids', 'issn_l': '0952-3278', 'issn': ['0952-3278', '1532-2823'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050115769', 'display_name': 'Silvia Della Bella', 'orcid': 'https://orcid.org/0000-0003-0818-5049'}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210087357', 'display_name': 'Ospedale Maggiore', 'ror': 'https://ror.org/0053ctp29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087357']}, {'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'S.Della Bella', 'raw_affiliation_strings': ['Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011970616', 'display_name': 'Monica Molteni', 'orcid': 'https://orcid.org/0000-0002-5990-3971'}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210087357', 'display_name': 'Ospedale Maggiore', 'ror': 'https://ror.org/0053ctp29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087357']}, {'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'M. Molteni', 'raw_affiliation_strings': ['Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049799922', 'display_name': 'Silvana Compasso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210087357', 'display_name': 'Ospedale Maggiore', 'ror': 'https://ror.org/0053ctp29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087357']}, {'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'S. Compasso', 'raw_affiliation_strings': ['Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091307388', 'display_name': 'C Zulian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210087357', 'display_name': 'Ospedale Maggiore', 'ror': 'https://ror.org/0053ctp29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087357']}, {'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'C. Zulian', 'raw_affiliation_strings': ['Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027903185', 'display_name': 'M Vanoli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210087357', 'display_name': 'Ospedale Maggiore', 'ror': 'https://ror.org/0053ctp29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087357']}, {'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'M. Vanoli', 'raw_affiliation_strings': ['Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051318790', 'display_name': 'Roberto Scorza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210087357', 'display_name': 'Ospedale Maggiore', 'ror': 'https://ror.org/0053ctp29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087357']}, {'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'R. Scorza', 'raw_affiliation_strings': ['Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Internal Medicine, Infectious Diseases and Immunopathology, IRCCS Ospedale Maggiore di Milano, University of Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5050115769'], 'corresponding_institution_ids': ['https://openalex.org/I189158943', 'https://openalex.org/I4210087357', 'https://openalex.org/I2803066834'], 'apc_list': {'value': 3510, 'currency': 'USD', 'value_usd': 3510, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.723, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.814919, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '56', 'issue': '3', 'first_page': '177', 'last_page': '184'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy in Cardiovascular Disease', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/iloprost', 'display_name': 'Iloprost', 'score': 0.9485667}, {'id': 'https://openalex.org/keywords/cyclooxygenase-2-inhibitors', 'display_name': 'Cyclooxygenase-2 Inhibitors', 'score': 0.521039}], 'concepts': [{'id': 'https://openalex.org/C2781103887', 'wikidata': 'https://www.wikidata.org/wiki/Q20817139', 'display_name': 'Iloprost', 'level': 3, 'score': 0.9485667}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.85396546}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.64947784}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.5251134}, {'id': 'https://openalex.org/C2781024287', 'wikidata': 'https://www.wikidata.org/wiki/Q774909', 'display_name': 'Thromboxane A2', 'level': 3, 'score': 0.4713302}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45780087}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37037593}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.31132382}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3027115}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30257016}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2960189}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16318041}], 'mesh': [{'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019796', 'descriptor_name': '15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016285', 'descriptor_name': 'Iloprost', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016285', 'descriptor_name': 'Iloprost', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011450', 'descriptor_name': 'Prostaglandin Endoperoxides, Synthetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011450', 'descriptor_name': 'Prostaglandin Endoperoxides, Synthetic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0952-3278(97)90531-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S9307485', 'display_name': 'Prostaglandins Leukotrienes and Essential Fatty Acids', 'issn_l': '0952-3278', 'issn': ['0952-3278', '1532-2823'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9089795', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1480454985', 'https://openalex.org/W1483824075', 'https://openalex.org/W1506916331', 'https://openalex.org/W1536787151', 'https://openalex.org/W1541948797', 'https://openalex.org/W1597479768', 'https://openalex.org/W1608418211', 'https://openalex.org/W1953360193', 'https://openalex.org/W1969849186', 'https://openalex.org/W1972365005', 'https://openalex.org/W1987175676', 'https://openalex.org/W2002055940', 'https://openalex.org/W2002713751', 'https://openalex.org/W2014559295', 'https://openalex.org/W2015211989', 'https://openalex.org/W2016849060', 'https://openalex.org/W2021137024', 'https://openalex.org/W2024715434', 'https://openalex.org/W2027083399', 'https://openalex.org/W2029744477', 'https://openalex.org/W2030087792', 'https://openalex.org/W2032825252', 'https://openalex.org/W2037311406', 'https://openalex.org/W2037380939', 'https://openalex.org/W2042034651', 'https://openalex.org/W2046921348', 'https://openalex.org/W2062206476', 'https://openalex.org/W2065564934', 'https://openalex.org/W2070944916', 'https://openalex.org/W2071643062', 'https://openalex.org/W2077532004', 'https://openalex.org/W2080492971', 'https://openalex.org/W2128779895', 'https://openalex.org/W2130114003', 'https://openalex.org/W2132413543', 'https://openalex.org/W2411851449', 'https://openalex.org/W2468119228', 'https://openalex.org/W2888951608', 'https://openalex.org/W397496451', 'https://openalex.org/W404210076', 'https://openalex.org/W4322388561'], 'related_works': ['https://openalex.org/W91404528', 'https://openalex.org/W648656546', 'https://openalex.org/W4248635396', 'https://openalex.org/W4238173675', 'https://openalex.org/W2399828145', 'https://openalex.org/W2397152751', 'https://openalex.org/W2039162551', 'https://openalex.org/W2030536220', 'https://openalex.org/W2025152579', 'https://openalex.org/W2021624237'], 'abstract_inverted_index': {'Cyclo-oxygenase': [0], 'pathway': [1], 'metabolites': [2], 'released': [3, 172], 'in': [4, 59, 93, 117, 121, 132, 173], 'the': [5, 18, 22, 28, 40, 60, 67, 88, 94, 97, 104, 139, 151, 174, 187], 'microenvironment': [6], 'by': [7, 48, 113, 130, 136], 'activated': [8], 'platelets': [9], 'and': [10, 46, 56, 71, 135, 168], 'endothelial': [11], 'cells': [12], 'are': [13, 143], 'potential': [14], 'local': [15], 'modulators': [16], 'of': [17, 31, 42, 62, 69, 82, 90, 99, 106, 110, 157, 166, 183, 189], 'immune': [19], 'response.': [20], 'In': [21, 124], 'present': [23], 'study,': [24], 'we': [25], 'have': [26], 'investigated': [27], 'modulatory': [29], 'role': [30], 'PGE2,': [32, 111], 'iloprost': [33, 74, 85, 114], '(prostacyclin': [34], 'analogue),': [35], 'U-46619': [36], '(thromboxane': [37], 'analogue)': [38], 'on': [39, 170, 186], 'release': [41, 68], 'IL-2,': [43], 'IFN-gamma,': [44, 72], 'TNF-alpha': [45, 91], 'IL-6': [47, 126, 171], 'T': [49], 'lymphocytes.': [50], 'Our': [51], 'results': [52, 142], 'show': [53], 'that': [54, 109], 'PGE2': [55, 65, 83, 131, 169], 'prostacyclin': [57], 'differ': [58], 'regulation': [61], 'cytokine': [63], 'production.': [64, 79], 'inhibited': [66], 'IL-2': [70], 'while': [73], 'did': [75, 177], 'not': [76, 178], 'affect': [77], 'their': [78], 'The': [80], 'addition': [81], 'or': [84], 'greatly': [86], 'decreased': [87], 'amount': [89], 'measured': [92], 'supernatants,': [95], 'although': [96], 'rates': [98], 'inhibition': [100, 112], 'differed': [101], 'according': [102], 'to': [103, 146], 'kind': [105], 'stimulation.': [107], 'Unlike': [108], 'was': [115, 128], 'stronger': [116], 'alloactivated': [118, 133], 'cultures': [119, 134], 'than': [120], 'PHA-stimulated': [122], 'ones.': [123], 'vitro': [125], 'production': [127, 188], 'stimulated': [129], 'iloprost,': [137], 'whatever': [138], 'stimulus.': [140], 'These': [141], 'probably': [144], 'due': [145], 'other': [147], 'cellular': [148], 'subsets': [149], 'contaminating': [150], 'T-lymphocyte': [152], 'preparations.': [153], 'After': [154], 'complete': [155], 'removal': [156], 'monocytes': [158], 'from': [159], 'cell': [160], 'cultures,': [161], 'there': [162], 'were': [163], 'inhibitory': [164], 'effects': [165], 'lloprost': [167], 'supernatants.': [175], 'We': [176], 'observe': [179], 'any': [180], 'significant': [181], 'effect': [182], 'thromboxane': [184], 'analogue': [185], 'either': [190], 'cytokine.': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054155470', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-13T11:31:19.520476', 'created_date': '2016-06-24'}