Title: Comparative study of cystatin C and serum creatinine in the estimative of glomerular filtration rate in children
Abstract: To compare estimated glomerular filtration rate (GFR) by Schwartz formula and cystatin C-derived formula in a large population of children with a large spectrum of renal disease. Serum creatinine, cystatin C and estimated GFR were determined in 273 children, 254 with renal disease, and a mean age of 10.0 ± 4.4 y. Nineteen children were used as control, with a mean age of 8.5 ± 4.2 y. The children had nephrotic syndrome (16.5%), glomerulonephritis (11.4%), neurogenic bladder (11.4%), hydronephrosis (9.8%), asymptomatic hematuria (11%), chronic renal disease (5.9%) and other diseases (11%). Cystatin C, creatinine, Schwartz estimated GFR and cystatin C estimated GFR (mean ± SD) were 1.30 ± 1.03 mg/dl, 0.82 ± 1.20 mg/l, 143 ± 72 ml/min/1.73 m2 and 88 ± 36 ml/min/1.73 m2, respectively. Although GFR estimated by creatinine and cystatin C had a significant correlation, the Bland–Altman analysis showed greater differences between GFR estimated by the 2 methods, with a mean difference of 50 ml/min. Besides, > 50% of the patients with a reduced cystatin C estimated GFR had a normal GFR when analyzed by the Schwartz formula. Our data shows that cystatin C-based GFR is more sensitive than previous study had demonstrated. It is important to perform studies in specific populations to determine the variability in GFR measurements.
Publication Year: 2008
Publication Date: 2008-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 25
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