Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2053713685', 'doi': 'https://doi.org/10.1097/01.lab.0000017372.76297.eb', 'title': 'Angiotensin II Angiogenic Effect In Vivo Involves Vascular Endothelial Growth Factor- and Inflammation-Related Pathways', 'display_name': 'Angiotensin II Angiogenic Effect In Vivo Involves Vascular Endothelial Growth Factor- and Inflammation-Related Pathways', 'publication_year': 2002, 'publication_date': '2002-06-01', 'ids': {'openalex': 'https://openalex.org/W2053713685', 'doi': 'https://doi.org/10.1097/01.lab.0000017372.76297.eb', 'mag': '2053713685', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12065685'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.lab.0000017372.76297.eb', 'pdf_url': 'https://www.nature.com/articles/3780472.pdf', 'source': {'id': 'https://openalex.org/S137146891', 'display_name': 'Laboratory Investigation', 'issn_l': '0023-6837', 'issn': ['0023-6837', '1530-0307'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/3780472.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5074641512', 'display_name': 'Radia Tamarat', 'orcid': 'https://orcid.org/0000-0002-7109-2593'}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Radia Tamarat', 'raw_affiliation_strings': ['INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université Paris 7-Denis Diderot, Paris, France.'], 'affiliations': [{'raw_affiliation_string': 'INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université Paris 7-Denis Diderot, Paris, France.', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089583231', 'display_name': 'Jean‐Sébastien Silvestre', 'orcid': 'https://orcid.org/0000-0003-3962-2205'}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I4210119095', 'display_name': 'Hôpital Lariboisière', 'ror': 'https://ror.org/02mqtne57', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210119095']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Sébastien Silvestre', 'raw_affiliation_strings': ['INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université, Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I4210119095', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059664767', 'display_name': 'Micheline Durie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119095', 'display_name': 'Hôpital Lariboisière', 'ror': 'https://ror.org/02mqtne57', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210119095']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Micheline Durie', 'raw_affiliation_strings': ['INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université, Paris, France', 'institution_ids': ['https://openalex.org/I4210119095', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026377797', 'display_name': 'Bernard Lévy', 'orcid': 'https://orcid.org/0000-0001-9596-5347'}, 'institutions': [{'id': 'https://openalex.org/I4210119095', 'display_name': 'Hôpital Lariboisière', 'ror': 'https://ror.org/02mqtne57', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210119095']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Bernard I Levy', 'raw_affiliation_strings': ['INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U541, Hôpital Lariboisière, IFR Circulation-Paris 7, Université, Paris, France', 'institution_ids': ['https://openalex.org/I4210119095', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4480, 'currency': 'USD', 'value_usd': 4480, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.237, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 220, 'citation_normalized_percentile': {'value': 0.970436, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '82', 'issue': '6', 'first_page': '747', 'last_page': '756'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Molecular Mechanisms of Angiogenesis and Vascular Function', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/matrigel', 'display_name': 'Matrigel', 'score': 0.8105004}, {'id': 'https://openalex.org/keywords/angiogenic-signaling', 'display_name': 'angiogenic signaling', 'score': 0.601139}, {'id': 'https://openalex.org/keywords/anti-angiogenic-therapy', 'display_name': 'anti-angiogenic therapy', 'score': 0.559578}, {'id': 'https://openalex.org/keywords/angiotensin', 'display_name': 'Angiotensin', 'score': 0.55709}, {'id': 'https://openalex.org/keywords/endothelial-cell-behavior', 'display_name': 'endothelial cell behavior', 'score': 0.556438}, {'id': 'https://openalex.org/keywords/angiotensin-ii-receptor', 'display_name': 'Angiotensin II Receptor', 'score': 0.55356}], 'concepts': [{'id': 'https://openalex.org/C2778608917', 'wikidata': 'https://www.wikidata.org/wiki/Q6787805', 'display_name': 'Matrigel', 'level': 3, 'score': 0.8105004}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.74740195}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.6844824}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6464816}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.60663384}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6050826}, {'id': 'https://openalex.org/C123915805', 'wikidata': 'https://www.wikidata.org/wiki/Q15332826', 'display_name': 'Angiotensin II receptor type 1', 'level': 4, 'score': 0.45445064}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4371978}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.38593683}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3502037}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3077372}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057911', 'descriptor_name': 'Angiotensin Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019331', 'descriptor_name': 'NG-Nitroarginine Methyl Ester', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019331', 'descriptor_name': 'NG-Nitroarginine Methyl Ester', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D044140', 'descriptor_name': 'Receptor, Angiotensin, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013777', 'descriptor_name': 'Tetrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013777', 'descriptor_name': 'Tetrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042442', 'descriptor_name': 'Vascular Endothelial Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.lab.0000017372.76297.eb', 'pdf_url': 'https://www.nature.com/articles/3780472.pdf', 'source': {'id': 'https://openalex.org/S137146891', 'display_name': 'Laboratory Investigation', 'issn_l': '0023-6837', 'issn': ['0023-6837', '1530-0307'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12065685', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.lab.0000017372.76297.eb', 'pdf_url': 'https://www.nature.com/articles/3780472.pdf', 'source': {'id': 'https://openalex.org/S137146891', 'display_name': 'Laboratory Investigation', 'issn_l': '0023-6837', 'issn': ['0023-6837', '1530-0307'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W125173813', 'https://openalex.org/W1506297407', 'https://openalex.org/W151723881', 'https://openalex.org/W1648957378', 'https://openalex.org/W1970017835', 'https://openalex.org/W1971006006', 'https://openalex.org/W1984584032', 'https://openalex.org/W1988403143', 'https://openalex.org/W1989049255', 'https://openalex.org/W2005961677', 'https://openalex.org/W2009029293', 'https://openalex.org/W2010031713', 'https://openalex.org/W2012505976', 'https://openalex.org/W2016207968', 'https://openalex.org/W2016411107', 'https://openalex.org/W2017658686', 'https://openalex.org/W2017800047', 'https://openalex.org/W2038545399', 'https://openalex.org/W2050991399', 'https://openalex.org/W2055769896', 'https://openalex.org/W2071062791', 'https://openalex.org/W2079825774', 'https://openalex.org/W2086719224', 'https://openalex.org/W2087221897', 'https://openalex.org/W2087848673', 'https://openalex.org/W2092171289', 'https://openalex.org/W2127558096', 'https://openalex.org/W2128635872', 'https://openalex.org/W2131033837', 'https://openalex.org/W2145879452', 'https://openalex.org/W2167186712', 'https://openalex.org/W2168981489', 'https://openalex.org/W2415928950', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W4247631657', 'https://openalex.org/W2748952813', 'https://openalex.org/W2334147949', 'https://openalex.org/W2151139437', 'https://openalex.org/W2069855804', 'https://openalex.org/W2063619316', 'https://openalex.org/W2048334412', 'https://openalex.org/W2034583712', 'https://openalex.org/W2024736606', 'https://openalex.org/W1974641745'], 'abstract_inverted_index': {'Although': [0], 'accumulating': [1], 'lines': [2], 'of': [3, 9, 51, 106, 121, 131, 188, 202, 207, 268, 272], 'evidence': [4], 'indicate': [5], 'the': [6, 18, 39, 91, 104, 109, 119, 129, 193, 273], 'proangiogenic': [7, 228], 'role': [8], 'angiotensin': [10], 'II': [11, 58, 64, 76, 100, 175, 227, 259], '(Ang': [12], 'II),': [13], 'little': [14], 'is': [15], 'known': [16], 'about': [17], 'molecular': [19, 31], 'mechanisms': [20], 'associated': [21, 139], 'with': [22, 56, 62, 74, 140, 240], 'such': [23], 'an': [24, 66, 135, 141, 254], 'effect.': [25, 229], 'This': [26], 'study': [27], 'aimed': [28], 'to': [29], 'identify': [30], 'events': [32], 'involved': [33, 266], 'in': [34, 38, 42, 90, 143, 249, 253, 255], 'Ang': [35, 57, 63, 75, 99, 174, 194, 226, 232, 258], 'II-induced': [36, 195, 233], 'angiogenesis': [37, 87, 196, 261], 'Matrigel': [40, 53, 55, 110], 'model': [41], 'mice.': [43, 251], 'C57Bl/6': [44], 'female': [45], 'mice': [46], 'received': [47], 'a': [48, 215], 'subcutaneous': [49], 'injection': [50], 'either': [52], 'or': [54, 73], '(10(-7)': [59], 'M)': [60], 'alone,': [61], 'and': [65, 77, 96, 124, 128, 161, 181, 197, 217, 248, 271], 'AT1': [67, 189, 263], 'receptor': [68, 79, 190], 'antagonist': [69, 80], '(candesartan,': [70], '10(-6)': [71, 82], 'M),': [72], 'AT2': [78, 203], '(PD123319,': [81], 'M).': [83], 'After': [84], '14': [85], 'days,': [86], 'was': [88, 138, 204, 236], 'assessed': [89, 184], 'Matrigel-plug': [92], 'by': [93, 102, 170, 185, 238], 'histological': [94], 'evaluation': [95], 'cellular': [97], 'counting.': [98], 'increased': [101], '1.9-fold': [103], 'number': [105], 'cells': [107], 'within': [108], '(p': [111], '<': [112, 151, 159, 165], '0.01': [113], 'versus': [114], 'control).': [115], 'Immunohistological': [116], 'analysis': [117], 'revealed': [118], 'presence': [120], 'macrophages,': [122], 'endothelial': [123, 145, 153], 'smooth': [125], 'muscle': [126], 'cells,': [127], 'development': [130], 'vascular-like': [132], 'structure.': [133], 'Such': [134], 'angiogenic': [136], 'effect': [137], 'increase': [142], 'vascular': [144], 'growth': [146], 'factor': [147], '(VEGF)': [148], '(1.5-fold,': [149], 'p': [150, 158, 164], '0.01),': [152, 160], 'nitric': [154, 241], 'oxide': [155, 242], '(eNOS)': [156], '(1.7-fold,': [157], 'cyclooxygenase-2': [162, 218], '(1.4-fold,': [163], '0.05)': [166], 'protein': [167, 198], 'levels': [168], 'measured': [169], 'Western': [171], 'blotting.': [172], 'Conversely,': [173], 'treatment': [176, 239], 'did': [177], 'not': [178], 'affect': [179], 'MMP-9': [180], 'MMP-2': [182], 'activity,': [183], 'zymography.': [186], 'Blockade': [187], 'completely': [191], 'prevented': [192], 'regulations,': [199], 'whereas': [200], 'that': [201], 'ineffective.': [205], 'Administration': [206], 'VEGF': [208], 'neutralizing': [209], 'antibody': [210], '(2.5': [211], 'microg': [212], 'ip': [213], 'twice': [214], 'week)': [216], 'selective': [219], 'inhibitor': [220, 244], '(nimesulide,': [221], '30': [222], 'mg/L)': [223], 'also': [224], 'hampered': [225], 'In': [230], 'addition,': [231], 'cell': [234], 'ingrowth': [235], 'impaired': [237], 'synthase': [243], '(L-NAME,': [245], '10': [246], 'mg/kg/day)': [247], 'eNOS-deficient': [250], 'Therefore,': [252], 'vivo': [256], 'model,': [257], 'induced': [260], 'through': [262], 'receptor,': [264], 'which': [265], 'activation': [267], 'VEGF/eNOS-related': [269], 'pathway': [270], 'inflammatory': [274], 'process.': [275]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2053713685', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-13T03:10:28.352985', 'created_date': '2016-06-24'}