Title: Electron-capture gas chromatographic assays of 5-nitroimidazole class of antimicrobials in blood
Abstract: Sensitive and selective electron-capture gas chromatographic methods for the determination of N-1-substituted 5-nitroimidazole class of antiprotozoals from blood are described. Metronidazole, secnidazole and ornidazole having a hydroxyl function in the N-1 substitution, were converted to their respective trimethylsilyl derivatives before chromatography on an OV-11 column. Tinidazole and satranidazole, devoid of the hydroxy group but containing a sulphur atom in the molecule, were chromatographed as such on the same stationary phase. Blood levels as low as 50 ng/ml for all the 5-nitroimidazoles have been measured with good precision. The methods can be readily utilized for pharmacokinetic studies.
Publication Year: 1984
Publication Date: 1984-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 42
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot