Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2053443014', 'doi': 'https://doi.org/10.1038/sj.bjp.0707332', 'title': 'Function, structure and therapeutic potential of complement C5a receptors', 'display_name': 'Function, structure and therapeutic potential of complement C5a receptors', 'publication_year': 2007, 'publication_date': '2007-07-02', 'ids': {'openalex': 'https://openalex.org/W2053443014', 'doi': 'https://doi.org/10.1038/sj.bjp.0707332', 'mag': '2053443014', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17603557', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2050825'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.bjp.0707332', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707332', 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707332', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048725428', 'display_name': 'Peter N. Monk', 'orcid': 'https://orcid.org/0000-0003-4637-3059'}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'P N Monk', 'raw_affiliation_strings': ['Academic Neurology Unit, School of Medicine and Biomedical Science, University of Sheffield, Sheffield, UK'], 'affiliations': [{'raw_affiliation_string': 'Academic Neurology Unit, School of Medicine and Biomedical Science, University of Sheffield, Sheffield, UK', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113612175', 'display_name': 'A.-M. Scola', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A‐M Scola', 'raw_affiliation_strings': ['Academic Neurology Unit, School of Medicine and Biomedical Science, University of Sheffield, Sheffield, UK'], 'affiliations': [{'raw_affiliation_string': 'Academic Neurology Unit, School of Medicine and Biomedical Science, University of Sheffield, Sheffield, UK', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003946834', 'display_name': 'Praveen K. Madala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'P Madala', 'raw_affiliation_strings': ['Centre for Drug Design and Development, Institute for Molecular Bioscience University of Queensland, Brisbane, Queensland, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Drug Design and Development, Institute for Molecular Bioscience University of Queensland, Brisbane, Queensland, Australia.', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053439487', 'display_name': 'David P. Fairlie', 'orcid': 'https://orcid.org/0000-0002-7856-8566'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'D P Fairlie', 'raw_affiliation_strings': ['Centre for Drug Design and Development, Institute for Molecular Bioscience University of Queensland, Brisbane, Queensland, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Drug Design and Development, Institute for Molecular Bioscience University of Queensland, Brisbane, Queensland, Australia.', 'institution_ids': ['https://openalex.org/I165143802']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.338, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 374, 'citation_normalized_percentile': {'value': 0.998936, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '152', 'issue': '4', 'first_page': '429', 'last_page': '448'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10993', 'display_name': 'Complement system in diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10993', 'display_name': 'Complement system in diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Coagulation, Bradykinin, Polyphosphates, and Angioedema', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/c5a-receptor', 'display_name': 'C5a receptor', 'score': 0.9099201}, {'id': 'https://openalex.org/keywords/anaphylatoxin', 'display_name': 'Anaphylatoxin', 'score': 0.5797462}], 'concepts': [{'id': 'https://openalex.org/C2779499704', 'wikidata': 'https://www.wikidata.org/wiki/Q5008266', 'display_name': 'C5a receptor', 'level': 4, 'score': 0.9099201}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.68940747}, {'id': 'https://openalex.org/C111684460', 'wikidata': 'https://www.wikidata.org/wiki/Q334848', 'display_name': 'Complement system', 'level': 3, 'score': 0.64944816}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6035449}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5959866}, {'id': 'https://openalex.org/C90582226', 'wikidata': 'https://www.wikidata.org/wiki/Q424292', 'display_name': 'Anaphylatoxin', 'level': 4, 'score': 0.5797462}, {'id': 'https://openalex.org/C54166955', 'wikidata': 'https://www.wikidata.org/wiki/Q658145', 'display_name': 'Chemotaxis', 'level': 3, 'score': 0.44490933}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.43897825}, {'id': 'https://openalex.org/C175773311', 'wikidata': 'https://www.wikidata.org/wiki/Q5156412', 'display_name': 'Complement receptor', 'level': 4, 'score': 0.43889722}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.38880634}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3209541}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3009835}], 'mesh': [{'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D044087', 'descriptor_name': 'Receptor, Anaphylatoxin C5a', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D044087', 'descriptor_name': 'Receptor, Anaphylatoxin C5a', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D015936', 'descriptor_name': 'Complement C5a', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044087', 'descriptor_name': 'Receptor, Anaphylatoxin C5a', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044087', 'descriptor_name': 'Receptor, Anaphylatoxin C5a', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.bjp.0707332', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707332', 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2050825', 'pdf_url': 'https://europepmc.org/articles/pmc2050825?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2050825', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17603557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.bjp.0707332', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707332', 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 264, 'referenced_works': ['https://openalex.org/W135904687', 'https://openalex.org/W1484805946', 'https://openalex.org/W1485186526', 'https://openalex.org/W1496640072', 'https://openalex.org/W1498977263', 'https://openalex.org/W1501153861', 'https://openalex.org/W1506918918', 'https://openalex.org/W1510455854', 'https://openalex.org/W1519358455', 'https://openalex.org/W1522434247', 'https://openalex.org/W1525207872', 'https://openalex.org/W1529949344', 'https://openalex.org/W1541068518', 'https://openalex.org/W1546290898', 'https://openalex.org/W1547803511', 'https://openalex.org/W1549204232', 'https://openalex.org/W1553869327', 'https://openalex.org/W1555752929', 'https://openalex.org/W1558446989', 'https://openalex.org/W1562405836', 'https://openalex.org/W1563349777', 'https://openalex.org/W1569422489', 'https://openalex.org/W1570213407', 'https://openalex.org/W1580525952', 'https://openalex.org/W1582349222', 'https://openalex.org/W1584856024', 'https://openalex.org/W1586560131', 'https://openalex.org/W1592028829', 'https://openalex.org/W1597762674', 'https://openalex.org/W1602141182', 'https://openalex.org/W1626627453', 'https://openalex.org/W1634549591', 'https://openalex.org/W1751327912', 'https://openalex.org/W1765347758', 'https://openalex.org/W1776603764', 'https://openalex.org/W1800839404', 'https://openalex.org/W1839443743', 'https://openalex.org/W1847565797', 'https://openalex.org/W1852412583', 'https://openalex.org/W1863355121', 'https://openalex.org/W1864331618', 'https://openalex.org/W1867704897', 'https://openalex.org/W1882029866', 'https://openalex.org/W1895961787', 'https://openalex.org/W1904288160', 'https://openalex.org/W1919495767', 'https://openalex.org/W1934648117', 'https://openalex.org/W1965480151', 'https://openalex.org/W1966071218', 'https://openalex.org/W1966460849', 'https://openalex.org/W1967024742', 'https://openalex.org/W1967562709', 'https://openalex.org/W1967563793', 'https://openalex.org/W1968544303', 'https://openalex.org/W1968931100', 'https://openalex.org/W1969797382', 'https://openalex.org/W1970816982', 'https://openalex.org/W1972084384', 'https://openalex.org/W1972712561', 'https://openalex.org/W1973220865', 'https://openalex.org/W1974710770', 'https://openalex.org/W1975140284', 'https://openalex.org/W1975593747', 'https://openalex.org/W1975807362', 'https://openalex.org/W1976673134', 'https://openalex.org/W1978496711', 'https://openalex.org/W1979613397', 'https://openalex.org/W1980941036', 'https://openalex.org/W1981051332', 'https://openalex.org/W1981821724', 'https://openalex.org/W1983148583', 'https://openalex.org/W1986074519', 'https://openalex.org/W1987036950', 'https://openalex.org/W1987577695', 'https://openalex.org/W1988077852', 'https://openalex.org/W1988384383', 'https://openalex.org/W1989707466', 'https://openalex.org/W1990231924', 'https://openalex.org/W1990843685', 'https://openalex.org/W1991378126', 'https://openalex.org/W1992887367', 'https://openalex.org/W1993075796', 'https://openalex.org/W1993346410', 'https://openalex.org/W1995921067', 'https://openalex.org/W1996077240', 'https://openalex.org/W1996259120', 'https://openalex.org/W1998304266', 'https://openalex.org/W1998827078', 'https://openalex.org/W1998875852', 'https://openalex.org/W2000748318', 'https://openalex.org/W2001647007', 'https://openalex.org/W2002049130', 'https://openalex.org/W2002720941', 'https://openalex.org/W2002894599', 'https://openalex.org/W2003458079', 'https://openalex.org/W2005918263', 'https://openalex.org/W2006485750', 'https://openalex.org/W2006770871', 'https://openalex.org/W2006860685', 'https://openalex.org/W2006993859', 'https://openalex.org/W2010381370', 'https://openalex.org/W2010465546', 'https://openalex.org/W2012049193', 'https://openalex.org/W2013230660', 'https://openalex.org/W2013997965', 'https://openalex.org/W2018213817', 'https://openalex.org/W2018848049', 'https://openalex.org/W2020521060', 'https://openalex.org/W2021073687', 'https://openalex.org/W2022827874', 'https://openalex.org/W2023082430', 'https://openalex.org/W2024875771', 'https://openalex.org/W2027715895', 'https://openalex.org/W2028177418', 'https://openalex.org/W2029023549', 'https://openalex.org/W2029043948', 'https://openalex.org/W2030579890', 'https://openalex.org/W2031408972', 'https://openalex.org/W2032604481', 'https://openalex.org/W2034345422', 'https://openalex.org/W2035701844', 'https://openalex.org/W2036012158', 'https://openalex.org/W2036821049', 'https://openalex.org/W2037513233', 'https://openalex.org/W2037553298', 'https://openalex.org/W2038824249', 'https://openalex.org/W2039348786', 'https://openalex.org/W2041171886', 'https://openalex.org/W2042342404', 'https://openalex.org/W2043057201', 'https://openalex.org/W2043287679', 'https://openalex.org/W2045109604', 'https://openalex.org/W2045439263', 'https://openalex.org/W2046271055', 'https://openalex.org/W2046868511', 'https://openalex.org/W2049132647', 'https://openalex.org/W2049455891', 'https://openalex.org/W2049648987', 'https://openalex.org/W2050892140', 'https://openalex.org/W2055585500', 'https://openalex.org/W2056876225', 'https://openalex.org/W2059213607', 'https://openalex.org/W2059327659', 'https://openalex.org/W2059939540', 'https://openalex.org/W2060379341', 'https://openalex.org/W2060831129', 'https://openalex.org/W2060923435', 'https://openalex.org/W2061551163', 'https://openalex.org/W2062243613', 'https://openalex.org/W2062250702', 'https://openalex.org/W2063588043', 'https://openalex.org/W2064469517', 'https://openalex.org/W2065467878', 'https://openalex.org/W2065860271', 'https://openalex.org/W2066071036', 'https://openalex.org/W2066672283', 'https://openalex.org/W2067803606', 'https://openalex.org/W2069818304', 'https://openalex.org/W2070234134', 'https://openalex.org/W2070670097', 'https://openalex.org/W2073220544', 'https://openalex.org/W2073618125', 'https://openalex.org/W2074553994', 'https://openalex.org/W2075287400', 'https://openalex.org/W2076324521', 'https://openalex.org/W2076412935', 'https://openalex.org/W2078899688', 'https://openalex.org/W2080210935', 'https://openalex.org/W2080459142', 'https://openalex.org/W2083234962', 'https://openalex.org/W2084231381', 'https://openalex.org/W2085134644', 'https://openalex.org/W2085445504', 'https://openalex.org/W2086012892', 'https://openalex.org/W2088072747', 'https://openalex.org/W2088364381', 'https://openalex.org/W2089429692', 'https://openalex.org/W2090393980', 'https://openalex.org/W2090616009', 'https://openalex.org/W2091565710', 'https://openalex.org/W2094083015', 'https://openalex.org/W2094951122', 'https://openalex.org/W2095464095', 'https://openalex.org/W2096444398', 'https://openalex.org/W2097361537', 'https://openalex.org/W2099233769', 'https://openalex.org/W2099656121', 'https://openalex.org/W2100066769', 'https://openalex.org/W2100616117', 'https://openalex.org/W2100656754', 'https://openalex.org/W2101962374', 'https://openalex.org/W2102332209', 'https://openalex.org/W2105393304', 'https://openalex.org/W2107807598', 'https://openalex.org/W2108893725', 'https://openalex.org/W2109665551', 'https://openalex.org/W2111010158', 'https://openalex.org/W2113368260', 'https://openalex.org/W2113721484', 'https://openalex.org/W2113722567', 'https://openalex.org/W2114150588', 'https://openalex.org/W2118323960', 'https://openalex.org/W2118397950', 'https://openalex.org/W2118796374', 'https://openalex.org/W2120663518', 'https://openalex.org/W2122719157', 'https://openalex.org/W2123719970', 'https://openalex.org/W2123815050', 'https://openalex.org/W2126564233', 'https://openalex.org/W2126606149', 'https://openalex.org/W2128425145', 'https://openalex.org/W2129019771', 'https://openalex.org/W2129277563', 'https://openalex.org/W2129637200', 'https://openalex.org/W2132878266', 'https://openalex.org/W2135689740', 'https://openalex.org/W2136635426', 'https://openalex.org/W2137655472', 'https://openalex.org/W2138170739', 'https://openalex.org/W2139367421', 'https://openalex.org/W2140537006', 'https://openalex.org/W2140865695', 'https://openalex.org/W2141107197', 'https://openalex.org/W2141962108', 'https://openalex.org/W2142065056', 'https://openalex.org/W2142679252', 'https://openalex.org/W2144054909', 'https://openalex.org/W2146659360', 'https://openalex.org/W2149103649', 'https://openalex.org/W2151948447', 'https://openalex.org/W2153047120', 'https://openalex.org/W2153373795', 'https://openalex.org/W2153737502', 'https://openalex.org/W2165919435', 'https://openalex.org/W2166421586', 'https://openalex.org/W2166630241', 'https://openalex.org/W2167870644', 'https://openalex.org/W2169295770', 'https://openalex.org/W2170672524', 'https://openalex.org/W2220511760', 'https://openalex.org/W22231059', 'https://openalex.org/W2260727139', 'https://openalex.org/W2334987852', 'https://openalex.org/W2336898156', 'https://openalex.org/W2406991078', 'https://openalex.org/W2409655930', 'https://openalex.org/W2413278239', 'https://openalex.org/W2419492843', 'https://openalex.org/W2426615298', 'https://openalex.org/W2465394505', 'https://openalex.org/W2485563582', 'https://openalex.org/W2536786462', 'https://openalex.org/W2614496215', 'https://openalex.org/W2949651128', 'https://openalex.org/W4210580032', 'https://openalex.org/W4236023569', 'https://openalex.org/W4239387674', 'https://openalex.org/W4240479390', 'https://openalex.org/W4253300416', 'https://openalex.org/W4313311044', 'https://openalex.org/W607595541', 'https://openalex.org/W72465559', 'https://openalex.org/W7926020', 'https://openalex.org/W91481017'], 'related_works': ['https://openalex.org/W84233676', 'https://openalex.org/W83452468', 'https://openalex.org/W4361225438', 'https://openalex.org/W4290300142', 'https://openalex.org/W3111780294', 'https://openalex.org/W3027518076', 'https://openalex.org/W2398398962', 'https://openalex.org/W2158443724', 'https://openalex.org/W2065760147', 'https://openalex.org/W1971102239'], 'abstract_inverted_index': {'Complement': [0], 'fragment': [1], '(C)5a': [2], 'is': [3, 73, 165], 'a': [4, 53, 74, 116, 246], '74': [5], 'residue': [6], 'pro-inflammatory': [7], 'polypeptide': [8], 'produced': [9], 'during': [10], 'activation': [11, 217], 'of': [12, 16, 56, 63, 122, 130, 133, 143, 215, 245], 'the': [13, 61, 119, 131, 209, 243], 'complement': [14], 'cascade': [15], 'serum': [17], 'proteins': [18, 98], 'in': [19, 138, 169, 226], 'response': [20], 'to': [21, 37, 94, 96], 'foreign': [22], 'surfaces': [23], 'such': [24], 'as': [25, 110, 115, 233], 'microorganisms': [26], 'and': [27, 47, 69, 85, 99, 113, 146, 150, 156, 159, 178, 182, 192, 211, 218], 'tissue': [28, 180], 'damaged': [29], 'by': [30, 242], 'physical': [31], 'or': [32], 'chemical': [33], 'injury.': [34], 'C5a': [35, 106, 134, 151, 155, 157, 164, 227, 248], 'binds': [36], 'at': [38], 'least': [39], 'two': [40], 'seven-transmembrane': [41], 'domain': [42], 'receptors,': [43], 'C5aR': [44, 72, 123, 199, 232], '(C5R1,': [45], 'CD88)': [46], 'C5L2': [48, 90], '(gpr77),': [49], 'expressed': [50], 'ubiquitously': [51], 'on': [52, 60, 198, 208], 'wide': [54], 'variety': [55], 'cells': [57, 65], 'but': [58], 'particularly': [59], 'surface': [62], 'immune': [64], 'like': [66], 'macrophages,': [67], 'neutrophils': [68], 'T': [70], 'cells.': [71], 'classical': [75], 'G': [76, 82, 86, 97], 'protein-coupled': [77], 'receptor': [78, 144, 162, 185, 210, 216, 228, 249], 'that': [79, 230], 'signals': [80], 'through': [81, 141], 'alpha': [83, 87], 'i': [84], '16,': [88], 'whereas': [89], 'does': [91], 'not': [92], 'appear': [93], 'couple': [95], 'has': [100, 135], 'no': [101], 'known': [102], 'signalling': [103], 'activity.': [104], 'Although': [105], 'was': [107], 'first': [108], 'described': [109], 'an': [111, 234], 'anaphylatoxin': [112], 'later': [114], 'leukocyte': [117], 'chemoattractant,': [118], 'widespread': [120], 'expression': [121], 'suggested': [124], 'more': [125], 'general': [126], 'functionality.': [127], 'Our': [128], 'understanding': [129], 'physiology': [132], 'improved': [136], 'significantly': [137], 'recent': [139], 'years': [140], 'exploitation': [142], 'knockout': [145], 'knocking': [147], 'mice,': [148], 'C5': [149], 'antibodies,': [152], 'soluble': [153], 'recombinant': [154], 'analogues': [158], 'newly': [160], 'developed': [161], 'antagonists.': [163], 'now': [166], 'also': [167, 251], 'implicated': [168], 'non-immunological': [170], 'functions': [171], 'associated': [172], 'with': [173], 'developmental': [174], 'biology,': [175], 'CNS': [176], 'development': [177], 'neurodegeneration,': [179], 'regeneration,': [181], 'haematopoiesis.': [183], 'Combined': [184], 'mutagenesis,': [186], 'molecular': [187], 'modelling,': [188], 'structure-activity': [189], 'relationship': [190], 'studies': [191], 'species': [193], 'dependence': [194], 'for': [195, 203, 212], 'ligand': [196, 205], 'potency': [197], 'have': [200], 'been': [201], 'helpful': [202], 'identifying': [204], 'binding': [206], 'sites': [207], 'defining': [213], 'mechanisms': [214], 'inactivation.': [219], 'This': [220], 'review': [221], 'will': [222], 'highlight': [223], 'major': [224], 'developments': [225], 'research': [229], 'support': [231], 'important': [235], 'therapeutic': [236], 'target.': [237], 'The': [238], 'intriguing': [239], 'possibilities': [240], 'raised': [241], 'existence': [244], 'non-signalling': [247], 'are': [250], 'discussed.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2053443014', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 23}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 34}, {'year': 2013, 'cited_by_count': 28}, {'year': 2012, 'cited_by_count': 28}], 'updated_date': '2024-12-10T01:06:26.038144', 'created_date': '2016-06-24'}