Publication Information

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'https://openalex.org/W2401633644', 'https://openalex.org/W29946730', 'https://openalex.org/W86737493'], 'related_works': ['https://openalex.org/W4246587942', 'https://openalex.org/W2122407726', 'https://openalex.org/W2064943475', 'https://openalex.org/W2053685014', 'https://openalex.org/W2041981800', 'https://openalex.org/W2035743526', 'https://openalex.org/W2031154171', 'https://openalex.org/W2020142500', 'https://openalex.org/W1999628035', 'https://openalex.org/W1970328728'], 'abstract_inverted_index': {'Mammalian': [0, 254], 'members': [1, 255, 1819], 'related': [2, 256, 2244], 'to': [3, 77, 91, 122, 148, 172, 257, 331, 345, 376, 402, 426, 559, 1001, 1006, 1218, 1610, 1772, 1775, 1802, 1879, 1943, 2021, 2245, 2497, 2653, 2933, 2947, 2977, 3025, 3146, 3154, 3207, 3293, 3826, 3961, 4095, 4219, 4316], 'Saccharomyces': [4, 258, 1886], 'cerevisiae': [5, 259, 2015, 2111, 2247], 'serine/threonine': [6, 119, 260, 373, 1103, 2611, 2923, 2952], 'kinase': [7, 38, 83, 127, 203, 232, 242, 261, 292, 337, 381, 457, 486, 496, 510, 524, 537, 538, 541, 542, 543, 546, 549, 551, 608, 784, 902, 1029, 1033, 1189, 1403, 1813, 2017, 2032, 2033, 2037, 2169, 2181, 2300, 2327, 2926, 2929, 3505, 3605, 3635, 3827], 'STE20': [8, 231, 262, 485, 2018, 2248, 2938], 'can': [9, 236, 263, 490, 2260, 4320], 'be': [10, 92, 237, 264, 346, 491, 1773, 1803, 2261], 'divided': [11, 265, 2262], 'into': [12, 266, 2263, 3173, 3231, 3281, 3299], 'two': [13, 267, 1097, 2264], 'subfamilies': [14, 268, 2265], 'based': [15, 269], 'on': [16, 270, 1096, 2010, 2253, 3122, 3695, 4214], 'their': [17, 108, 271, 362, 560, 1026, 2254, 2391], 'structure': [18, 272], 'and': [19, 40, 49, 66, 142, 178, 184, 244, 273, 294, 303, 320, 396, 432, 438, 498, 557, 582, 675, 678, 965, 1187, 1224, 1232, 1316, 1410, 1550, 1616, 1769, 1934, 1940, 2039, 2117, 2146, 2148, 2188, 2195, 2203, 2297, 2302, 2312, 2337, 2343, 2390, 2445, 2506, 2533, 2728, 2859, 2884, 2886, 2989, 3106, 3116, 3142, 3150, 3205, 3229, 3275, 3297, 3304, 3328, 3382, 3417, 3425, 3453, 3495, 3502, 3543, 3576, 3586, 3598, 3602, 3652, 3699, 3732, 3770, 3816, 3824, 3908, 3966, 3977, 4010, 4022, 4050, 4065, 4100, 4137, 4147, 4178, 4400], 'function.': [20, 110, 274, 364, 2958], 'The': [21, 51, 162, 275, 305, 416, 585, 987, 1019, 1593, 2601, 3057, 3101, 3166, 3308, 3315, 3499, 3968, 3991, 4060, 4209, 4380], 'PAK': [22, 276, 2285, 2323, 2332], 'subfamily': [23, 277, 2936], 'is': [24, 41, 54, 105, 205, 215, 278, 295, 308, 359, 459, 469, 997, 1091, 1396, 1600, 1876, 2142, 2197, 3003, 3243, 4162, 4308], 'characterized': [25, 279], 'by': [26, 43, 56, 94, 168, 208, 240, 280, 297, 310, 348, 422, 462, 494, 1025, 1094, 1100, 1398, 1400, 1805, 3135, 3284, 3312, 3422, 3552, 3629, 3672, 3692, 3701, 3957, 4006, 4080, 4089, 4114], 'an': [27, 62, 281, 316, 2288, 2308, 3258, 3713, 4163, 4314, 4392], 'N-terminal': [28, 63, 80, 282, 317, 334, 523, 781, 2289, 2309, 3260], 'p21-binding': [29, 69, 283, 323, 2290, 2315], 'domain': [30, 65, 284, 319, 2291, 2311, 2930, 2943, 3018, 4338], '(also': [31, 285, 2292], 'known': [32, 106, 286, 360, 603, 752, 1030, 2293], 'as': [33, 287, 575, 605, 670, 753, 1031, 1222, 1932, 2294, 3039, 3133, 3189, 3509, 3659, 3843, 3845, 3928, 4168, 4341], 'CRIB': [34, 288, 2295], 'domain),': [35, 289], 'a': [36, 95, 115, 290, 349, 369, 595, 1810, 2168, 2184, 2189, 2237, 2298, 2325, 2607, 2920, 2948, 3008, 3027, 3060, 3096, 3244, 3459, 4035, 4045, 4169, 4252, 4327, 4342, 4373, 4401, 4412], 'C-terminal': [37, 291, 2299], 'domain,': [39, 293], 'regulated': [42, 239, 296, 493, 1397], 'the': [44, 57, 68, 123, 131, 137, 175, 179, 226, 230, 298, 311, 322, 377, 385, 391, 429, 433, 480, 484, 992, 1002, 1747, 1883, 1941, 2013, 2025, 2030, 2035, 2040, 2044, 2179, 2233, 2284, 2303, 2314, 2335, 2500, 2529, 2917, 2934, 2978, 2994, 2998, 3107, 3136, 3156, 3159, 3174, 3218, 3250, 3255, 3294, 3446, 3503, 3540, 3549, 3567, 3673, 3848, 3851, 3975, 3978, 4029, 4066, 4103, 4172, 4215, 4220, 4335, 4365, 4385, 4408], 'small': [45, 180, 299, 434, 2501], 'GTP-binding': [46, 181, 300, 435, 2503], 'proteins': [47, 182, 301, 436, 2504, 4318], 'Rac1': [48, 183, 302, 437, 2505], 'Cdc42Hs.': [50, 185, 304, 439], 'second': [52, 306, 2602], 'group': [53, 307, 2603], 'represented': [55, 309], 'GCK-like': [58, 124, 312, 378, 2304, 2935], 'members,': [59, 313], 'which': [60, 314, 1090, 1405, 2141, 2306, 2493], 'contain': [61, 315], 'catalytic': [64, 318, 995, 2310], 'lack': [67, 321], 'domain.': [70, 324, 2316], 'Some': [71, 325], 'of': [72, 97, 140, 164, 229, 326, 351, 394, 418, 483, 553, 597, 1004, 1595, 1749, 1777, 1874, 2024, 2029, 2240, 2330, 2531, 2604, 2610, 2919, 2937, 2956, 2980, 2997, 3007, 3162, 3178, 3222, 3234, 3257, 3262, 3302, 3415, 3437, 3569, 3634, 3643, 3649, 3655, 3675, 3678, 3724, 3736, 3832, 3839, 3970, 3999, 4015, 4028, 4212, 4223, 4339, 4367, 4376, 4384, 4404], 'them': [73, 327], 'have': [74, 88, 113, 328, 342, 367, 1893, 2114, 2249, 3330], 'been': [75, 89, 329, 343, 1307, 1894, 2115, 2250, 2320, 3331], 'demonstrated': [76, 330], 'induce': [78, 130, 332, 384, 2967], 'c-Jun': [79, 333, 522, 780], 'kinase/stress-activated': [81, 335], 'protein': [82, 336, 509, 527, 536, 540, 548, 601, 607, 783, 1028, 1229, 2326, 2340, 2964, 3015, 3186, 3658, 3835, 3842, 4166], '(JNK/SAPK)': [84, 338, 785], 'cascade,': [85, 339], 'while': [86, 340, 1799], 'others': [87, 341], 'shown': [90, 344, 1309, 1801, 2020, 2321], 'activated': [93, 347, 1093, 1215, 1804], 'subset': [96, 350], 'stress': [98, 352, 583, 1618, 2782], 'conditions': [99, 353], 'or': [100, 199, 354, 453, 1015, 1034, 3224, 3237, 3267, 3440, 3730, 3739, 3757, 3806, 3836, 3920, 4084, 4107, 4128], 'apoptotic': [101, 355], 'agents,': [102, 356], 'although': [103, 357], 'little': [104, 358], 'about': [107, 361], 'specific': [109, 363], 'Here,': [111, 365], 'we': [112, 155, 366, 409, 2915, 2960, 4325], 'identified': [114, 368, 1895, 4079, 4167], 'novel': [116, 370, 2921], 'human': [117, 149, 371, 403, 2392, 2922, 3034, 3108, 3124, 4328], 'STE20-related': [118, 372], 'kinase,': [120, 374, 2924, 2953], 'belonging': [121, 375], 'subfamily.': [125, 379], 'This': [126, 380, 1871], 'does': [128, 189, 193, 382, 443, 447, 2965], 'not': [129, 190, 206, 383, 444, 460, 1877, 2966, 4310], 'JNK/SAPK': [132, 165, 252, 386, 419, 506, 1313, 2532, 2968, 2981], 'pathway,': [133, 387], 'but,': [134, 212, 388, 466], 'instead,': [135, 389], 'inhibits': [136, 390], 'basal': [138, 392], 'activity': [139, 204, 235, 393, 458, 489, 996, 1748, 3002, 3626], 'JNK/SAPK,': [141, 395], 'diminishes': [143, 397], 'its': [144, 398, 1320, 2941, 2971, 4305], 'activation': [145, 399, 1020, 1321, 2530], 'in': [146, 400, 568, 999, 1216, 1597, 2043, 2144, 2174, 2973, 3171, 3211, 3387, 3403, 3458, 3631, 3750, 3847, 3982, 3996, 4002, 4012, 4044, 4074, 4255], 'response': [147, 401, 1000, 1217, 1942], 'epidermal': [150, 404, 515, 518, 1011, 4173], 'growth': [151, 405, 516, 519, 554, 1012, 4174], 'factor': [152, 406, 517, 520, 1013, 4175], '(EGF).': [153, 407], 'Therefore,': [154, 408], 'designated': [156, 410, 4369], 'this': [157, 411, 2913, 2963, 4224], 'molecule': [158, 412], 'JIK': [159, 169, 188, 202, 223, 413, 423, 442, 456, 477, 2987, 3102, 3163, 3223, 3542, 3625], 'forJNK/SAPK-inhibitory': [160, 414], 'kinase.': [161, 415], 'inhibition': [163, 417, 2979], 'signaling': [166, 420, 4257], 'pathway': [167, 421, 2046], 'was': [170, 424, 2019, 3023, 3059, 3120, 3131, 3169, 3187, 3420, 3627, 3926, 3972, 3980, 3994, 4031, 4042, 4062, 4157, 4217], 'found': [171, 425, 2961], 'occur': [173, 427], 'between': [174, 428, 2192], 'EGF': [176, 219, 430, 473, 2984, 3762], 'receptor': [177, 220, 431, 474, 521, 1007, 4176, 4181, 4225], 'In': [186, 440, 660, 1211, 1882, 2176, 2232, 2912], 'contrast,': [187, 441, 1212], 'activate': [191, 445], 'nor': [192, 446], 'it': [194, 214, 448, 468, 1607, 2318, 2991], 'inhibit': [195, 449], 'ERK2,': [196, 450], 'ERK6,': [197, 451, 750, 3815], 'p38,': [198, 452, 3814], 'ERK5.': [200, 454], 'Furthermore,': [201, 455, 2940, 2983, 4407], 'modulated': [207, 461], 'any': [209, 463], 'exogenous': [210, 464], 'stimuli,': [211, 465], 'interestingly,': [213, 467], 'dramatically': [216, 470], 'decreased': [217, 471], 'upon': [218, 472, 3005], 'activation.': [221, 253, 475, 507, 2982], 'Thus,': [222, 476], 'might': [224, 478], 'represent': [225, 479, 1809, 2993], 'first': [227, 481, 2995], 'member': [228, 482, 2996], 'family': [233, 487, 1818, 2328], 'whose': [234, 245, 488, 499, 994, 2928, 3001], 'negatively': [238, 492, 2985], 'tyrosine': [241, 495, 1008, 4182], 'receptors,': [243, 497], 'downstream': [246, 500], 'targets': [247, 501], 'inhibit,': [248, 502], 'rather': [249, 503], 'than': [250, 504], 'enhance,': [251, 505], 'mitogen-activated': [508, 535, 539, 606], 'hemagglutinin': [511], 'polyacrylamide': [512, 3697], 'gel': [513], 'electrophoresis': [514, 3694], 'myelin': [525, 3656, 3840], 'basic': [526, 3657, 3841], 'phosphate-buffered': [528], 'saline': [529], 'tumor': [530], 'necrosis': [531], 'factor-α': [532], 'dithiothreitol': [533], 'glutathioneS-transferase': [534], 'extracellular': [544, 671], 'signal-regulated': [545, 672], 'stress-activated': [547], 'JNK/SAPK-inhibitory': [550], 'Binding': [552], 'factors,': [555], 'hormones,': [556], 'cytokines': [558, 1234, 1612], 'receptors': [561], 'regulates': [562, 2986], 'intracellular': [563], 'signal': [564], 'transduction': [565], 'pathways,': [566], 'which,': [567, 4368], 'turn,': [569], 'control': [570], 'diverse': [571, 590, 1928], 'cellular': [572, 4306], 'functions': [573], 'such': [574, 1221, 1931], 'metabolism,': [576], 'proliferation,': [577], 'differentiation,': [578], 'programmed': [579], 'cell': [580, 1937, 2201, 3009], 'death,': [581], 'responses.': [584], 'biochemical': [586], 'routes': [587], 'mediating': [588], 'these': [589, 663, 2256], 'biological': [591, 1929], 'responses': [592], 'often': [593], 'involve': [594], 'series': [596], 'sequentially': [598], 'organized': [599], 'serine-threonine': [600, 2016], 'kinases,': [602, 1104, 1404, 2341, 2612], 'collectively': [604], '(MAPK)1': [609], 'cascades': [610], '(1Cobb': [611], 'M.H.': [612, 2214, 2216], 'Goldsmith': [613, 1076], 'E.J.': [614], 'J.': [615, 633, 715, 734, 832, 844, 846, 949, 978, 1125, 1137, 1166, 1175, 1281, 1293, 1295, 1333, 1350, 1356, 1461, 1463, 1467, 1489, 1511, 1541, 1568, 1622, 1654, 1671, 1692, 1730, 1732, 1760, 1790, 1821, 1830, 1846, 1855, 2058, 2157, 2269, 2371, 2374, 2410, 2433, 2454, 2473, 2477, 2618, 2626, 2641, 2661, 2662, 2745, 2749, 2768, 2772, 2792, 2799, 2821, 2822, 2845, 2864, 2865, 3194, 3781, 3790, 3889, 3894, 3933, 4200, 4274, 4419], 'Biol.': [616, 634, 735, 1057, 1178, 1490, 1512, 1569, 1655, 1682, 1831, 1856, 1985, 2272, 2375, 2411, 2479, 2663, 2800, 2823, 2866, 3372, 3791, 3895, 4296, 4421], 'Chem.': [617, 635, 736, 1491, 1513, 1570, 1656, 1832, 1857, 2376, 2412, 2664, 2801, 2824, 2867, 3792, 3896], '1995;': [618, 737, 1362, 1387, 1915, 1986, 2133, 2224, 2377, 2413, 2437, 2458, 2553, 2575, 2593, 2825, 2848, 3351, 3528, 3871, 4240, 4297], '270:': [619, 738, 2378, 2414, 2826], '14843-14846Abstract': [620], 'Full': [621, 623, 639, 704, 740, 742, 806, 1255, 1495, 1497, 1517, 1519, 1574, 1576, 1660, 1662, 1711, 1737, 1836, 1838, 1861, 1863, 1904, 1918, 1970, 2001, 2276, 2380, 2382, 2416, 2418, 2483, 2485, 2556, 2578, 2668, 2805, 2807, 2828, 2830, 2871, 2873, 3354, 3531, 3796, 3798, 3874, 3900], 'Text': [622, 624, 640, 705, 741, 743, 807, 1256, 1496, 1498, 1518, 1520, 1575, 1577, 1661, 1663, 1712, 1738, 1837, 1839, 1862, 1864, 1905, 1919, 1971, 2002, 2277, 2381, 2383, 2417, 2419, 2484, 2486, 2557, 2579, 2669, 2806, 2808, 2829, 2831, 2872, 2874, 3355, 3532, 3797, 3799, 3875, 3901], 'PDF': [625, 641, 706, 744, 808, 1257, 1499, 1521, 1578, 1664, 1713, 1739, 1840, 1865, 1906, 1920, 1972, 2003, 2278, 2384, 2420, 2487, 2558, 2580, 2670, 2809, 2832, 2875, 3356, 3533, 3800, 3876, 3902], 'PubMed': [626, 642, 655, 707, 722, 745, 775, 809, 826, 851, 896, 943, 960, 982, 1045, 1061, 1085, 1119, 1142, 1159, 1182, 1206, 1258, 1275, 1300, 1342, 1365, 1390, 1426, 1451, 1474, 1500, 1522, 1545, 1579, 1633, 1665, 1686, 1714, 1740, 1764, 1794, 1841, 1866, 1907, 1921, 1955, 1973, 1989, 2004, 2062, 2081, 2104, 2136, 2163, 2227, 2279, 2359, 2385, 2421, 2440, 2461, 2488, 2522, 2559, 2581, 2596, 2630, 2646, 2671, 2701, 2723, 2753, 2776, 2810, 2833, 2851, 2876, 2904, 3052, 3200, 3357, 3376, 3534, 3801, 3877, 3903, 3949, 4204, 4278, 4300, 4354, 4425], 'Scopus': [627, 656, 708, 723, 746, 776, 810, 827, 852, 897, 944, 961, 983, 1046, 1062, 1086, 1120, 1143, 1160, 1183, 1207, 1259, 1276, 1301, 1343, 1366, 1391, 1427, 1452, 1475, 1501, 1523, 1546, 1580, 1634, 1666, 1687, 1715, 1741, 1765, 1795, 1842, 1867, 1908, 1922, 1956, 1974, 1990, 2005, 2063, 2082, 2105, 2137, 2164, 2228, 2280, 2360, 2386, 2422, 2441, 2462, 2489, 2523, 2560, 2582, 2597, 2631, 2647, 2702, 2724, 2754, 2777, 2811, 2834, 2852, 2877, 2905, 3053, 3201, 3358, 3377, 3535, 3802, 3878, 3950, 4205, 4279, 4301, 4355, 4426], '(1669)': [628], 'Google': [629, 643, 658, 710, 725, 748, 778, 812, 829, 854, 899, 946, 963, 985, 1048, 1064, 1088, 1122, 1145, 1162, 1185, 1209, 1261, 1278, 1303, 1345, 1368, 1393, 1429, 1454, 1477, 1503, 1525, 1548, 1582, 1636, 1668, 1689, 1717, 1743, 1767, 1797, 1844, 1869, 1910, 1924, 1958, 1976, 1992, 2007, 2065, 2084, 2107, 2139, 2166, 2230, 2282, 2362, 2388, 2424, 2443, 2464, 2491, 2525, 2562, 2584, 2599, 2633, 2649, 2672, 2704, 2726, 2756, 2779, 2813, 2836, 2854, 2879, 2907, 3055, 3203, 3360, 3379, 3537, 3804, 3880, 3904, 3952, 4207, 4243, 4281, 4303, 4357, 4428], 'Scholar,': [630, 644, 711, 813, 830, 855, 947, 1049, 1065, 1123, 1146, 1262, 1279, 1346, 1369, 1430, 1455, 1478, 1504, 1637, 1669, 1690, 1718, 1911, 1959, 1977, 1993, 2066, 2085, 2363, 2425, 2465, 2563, 2585, 3361, 3881, 4282], '2Davis': [631], 'R.J.': [632, 801, 821, 955, 1250, 1270, 1628, 1679, 1825, 1897, 3785], '1993;': [636, 1156, 1179, 1203, 1423, 1998, 2078, 2101, 4201, 4275], '268:': [637, 1388], '14553-14556Abstract': [638], '3Su': [645], 'B.': [646, 787, 795, 817, 1150, 1236, 1244, 1266, 1348, 1440, 1677, 1981, 2739, 4284], 'Karin': [647, 798, 1247, 1384, 1445, 2572], 'M.': [648, 697, 789, 799, 842, 968, 972, 1051, 1053, 1067, 1071, 1079, 1152, 1238, 1248, 1291, 1385, 1436, 1446, 1457, 1565, 1651, 1698, 1758, 1780, 1784, 1823, 1848, 1850, 2056, 2095, 2471, 2539, 2573, 2587, 2622, 2686, 2709, 2735, 3337, 3365, 3367, 3514, 3783, 3857, 4418], 'Curr.': [649, 1054, 1948, 1982, 2478], 'Opin.': [650, 1055, 1949, 1983], 'Immunol.': [651], '1996;': [652, 772, 1082, 1492, 1542, 1571, 1657, 1683, 1833, 2480, 2720, 2750, 2773, 2901, 3793], '8:': [653, 2161], '402-411Crossref': [654], '(726)': [657], 'Scholar).': [659, 986, 1210, 1304, 1394, 1583, 1744, 1870, 1925, 2008, 2108, 2231, 2600, 3056, 3083, 3380, 3538, 3905, 3953, 4208, 4244, 4358], 'mammalian': [661, 1102, 1598, 1880, 2241, 2257], 'cells,': [662], 'kinases': [664, 673, 1009, 2113, 2242, 2259, 2605, 3000, 4183], 'include': [665, 1406, 2118], 'p44/42MAPK': [666], 'also': [667, 751], 'known,': [668], 'respectively,': [669, 3145, 3918], '1': [674, 1190, 3475, 3488, 3558, 3587, 3618, 3639, 3722, 3734, 3997, 4026], '2': [676, 2887, 3484, 3622, 3742, 4018], '(ERK-1': [677], 'ERK-2)': [679], '(4Boulton': [680], 'T.': [681, 793, 797, 838, 1242, 1246, 1287, 1352, 1459, 1531, 1675, 1704, 2348, 2403, 2511, 2549, 2717, 2743, 2770, 2788, 3068, 3347, 3524, 3867, 3939, 4193, 4267], 'Nye': [682], 'S.': [683, 691, 770, 865, 912, 1069, 1148, 1486, 1539, 1696, 1728, 2014, 2068, 2076, 2110, 2155, 2206, 2222, 2246, 2365, 2429, 2450, 2475, 2620, 2696, 2786, 2899, 3070, 3944], 'Robbins': [684, 1074, 2211], 'D.': [685, 867, 869, 914, 916, 1073, 1075, 1133, 1469, 1535, 1557, 1559, 1643, 1645, 1702, 1979, 2050, 2052, 2054, 2089, 2091, 2097, 2212, 3931, 3935], 'Ip': [686], 'N.': [687, 695, 1168, 1170, 2547, 2741, 2747, 3345, 3522, 3865, 3885], 'Radziejewska': [688], 'E.': [689, 836, 840, 1077, 1285, 1289, 1726, 2048, 2087, 2126, 2210, 2346, 2397, 2509, 2796], 'Morgenbesser': [690], 'DePinho': [692], 'R.': [693, 974, 1358, 1360, 1442, 1537, 1786, 2070, 2153, 2893], 'Panayotatos': [694], 'Cobb': [696, 1052, 2213, 2621], 'Yancopoulos': [698], 'G.': [699, 729, 1110, 1173, 1201, 1383, 1421, 1444, 1533, 1947, 1963, 2405, 2659, 2684, 3942], 'Cell.': [700, 802, 1177, 1251, 1681, 1707, 1733, 1914, 2552, 2574, 3350, 3371, 3527, 3870, 4295], '1991;': [701, 719, 1116, 3197, 3946, 4422], '65:': [702], '663-675Abstract': [703], '(1570)': [709], '5Sturgill': [712], 'T.W.': [713], 'Wu': [714, 790, 818, 1239, 1267, 1353], 'Biochim.': [716], 'Biophys.': [717], 'Acta.': [718], '1092:': [720], '350-357Crossref': [721], '(356)': [724], 'Scholar),': [726, 749, 779, 900, 964, 1089, 1163, 1186, 1526, 1549, 1768, 1798, 2140, 2167, 2389, 2492, 2526, 2673, 3805, 4304, 4429], 'ERK5': [727, 3779], '(6Zhou': [728], 'Bao': [730], 'Z.Q.': [731], 'Dixon': [732, 3193], 'J.E.': [733, 877, 924], '12665-12669Abstract': [739], '(545)': [747], 'SAPK3': [754], '(7Lechner': [755], 'C.': [756, 1193, 1195, 1379, 1413, 1415, 1438, 2124, 2399, 2407, 2680, 2715, 3045, 4347], 'Zahalka': [757], 'M.A.': [758, 2267], 'Giot': [759], 'J.F.': [760], 'Moller': [761], 'N.P.': [762], 'Ullrich': [763], 'A.': [764, 771, 970, 1039, 1154, 1197, 1371, 1373, 1417, 1432, 1434, 1529, 1700, 1706, 1752, 1782, 2077, 2208, 2223, 2565, 2567, 2571, 2589, 2591, 2697, 2737, 2766, 2900, 3937], 'Proc.': [765, 2071, 2217, 2691, 2894], 'Natl.': [766, 2072, 2218, 2692, 2895], 'Acad.': [767, 2073, 2219, 2693, 2896], 'Sci.': [768, 1900, 1966, 2074, 2220, 2694, 2897], 'U.': [769, 1114, 1135, 2075, 2221, 2695, 2898], '93:': [773, 2902], '4355-4359Crossref': [774], '(281)': [777], 'kinases/stress-activated': [782], '(8Derijard': [786, 1235], 'Hibi': [788, 1237], 'I.H.': [791, 819, 1240, 1268], 'Barrett': [792, 1241, 1351, 1674], 'Su': [794, 1243], 'Deng': [796, 1245], 'Davis': [800, 820, 1249, 1269, 1359, 1441, 1678, 2069], '1994;': [803, 823, 848, 893, 940, 957, 1252, 1272, 1297, 1339, 1448, 1471, 1630, 1708, 1734, 1901, 1952, 1967, 2160, 2356, 2519, 2665, 3897], '76:': [804, 1253], '1025-1037Abstract': [805, 1254], '(2980)': [811, 1260], '9Galcheva-Gargova': [814, 1263], 'Z.': [815, 1264, 1567, 1653, 2690, 3043, 4229, 4345], 'Derijard': [816, 1265, 1439, 1676], 'Science.': [822, 956, 1155, 1202, 1271, 1361, 1386, 1422, 1447, 1629, 2436, 2457, 2592, 3945], '265:': [824, 958, 1273, 1631], '806-808Crossref': [825, 1274], '(538)': [828, 1277], '10Kyriakis': [831, 1280], 'Banerjee': [833, 1130, 1282], 'P.': [834, 976, 1037, 1112, 1131, 1283, 1482, 1506, 1694, 1754, 1788, 2545, 2657, 3343, 3520, 3863, 3883, 4191, 4227, 4265], 'Nikolakaki': [835, 1284], 'Dai': [837, 1286, 1458], 'Rubie': [839, 1288], 'Ahmad': [841, 1290, 1530], 'Avruch': [843, 1136, 1292, 1332], 'Woodgett': [845, 1294, 1330, 1466, 2744], 'Nature.': [847, 892, 939, 1115, 1138, 1296, 1338, 1470, 2355, 2518], '369:': [849, 1298], '156-160Crossref': [850, 1299], '(2440)': [853, 1302], '11Lee': [856], 'J.C.': [857, 904, 2541, 3339, 3516, 3859], 'Laydon': [858, 905], 'J.T.': [859, 906], 'McDonnell': [860, 907], 'P.C.': [861, 908], 'Gallagher': [862, 909], 'T.F.': [863, 910], 'Kumar': [864, 911], 'Green': [866, 913], 'McNulty': [868, 915], 'Blumenthal': [870, 917], 'M.J.': [871, 918, 3363], 'Heys': [872, 919], 'J.R.': [873, 887, 920, 934, 1331, 2128], 'Landvatter': [874, 921], 'S.W.': [875, 922], 'Strickler': [876, 923], 'McLaughlin': [878, 925], 'M.M.': [879, 926], 'Siemens': [880, 927], 'I.R.': [881, 928], 'Fisher': [882, 929], 'S.M.': [883, 930], 'Livi': [884, 931], 'G.P.': [885, 932], 'White': [886, 933], 'Adams': [888, 935], 'J.L.': [889, 936, 1480, 1508, 2467, 3887], 'Young': [890, 937], 'P.R.': [891, 938], '372:': [894, 941, 1340, 1472], '739-746Crossref': [895, 942], '(3175)': [898, 945], 'p38': [901, 1596, 1778, 2534], '(11Lee': [903], '12Han': [948], 'Lee': [950, 1623, 1828, 1851, 3788], 'J.D.': [951, 1624, 1829, 1852, 3789], 'Bibbs': [952, 1625], 'L.': [953, 1465, 1626, 1722, 2093, 2354, 2409, 2469, 2517, 2733, 2889, 4187, 4261], 'Ulevitch': [954, 1357, 1627, 1824, 3784], '808-811Crossref': [959, 1632], '(2438)': [962, 1635], 'SAPK4': [966, 1770], '(13Goedert': [967, 1779], 'Cuenda': [969, 1781], 'Craxton': [971, 1783], 'Jakes': [973, 1785], 'Cohen': [975, 1693, 1753, 1787], 'EMBO': [977, 1540, 1759, 1789, 2057, 2625, 2748, 2771, 4199, 4273], '1997;': [979, 1042, 1058, 1514, 1761, 1791, 1858, 2273, 2627, 2643, 2698, 2802, 2868, 3049, 4351], '16:': [980, 1684, 1762, 1792, 2628], '3563-3571Crossref': [981, 1793], '(360)': [984, 1796], 'best': [988], 'studied': [989], 'MAPKs': [990, 1875, 2041], 'are': [991, 1214, 1590, 2494], 'ERKs,': [993], 'elevated': [998], 'binding': [1003, 4210], 'ligands': [1005], '(i.e.': [1010], 'receptors)': [1014], 'G': [1016], 'protein-coupled': [1017], 'receptors.': [1018], 'occurs': [1021], 'after': [1022, 3444, 4092], 'phosphorylation': [1023, 1095, 1399], 'catalyzed': [1024], 'upstream': [1027, 1401, 1585, 2023], 'MAPK': [1032, 1402, 1817, 1891, 2026, 2031, 2036], 'MEK': [1035, 1188], '(14Sugden': [1036], 'Clerk': [1038], 'Cell': [1040, 1056, 1984, 2271, 4420], 'Signal.': [1041], '9:': [1043, 1059, 1999, 2134], '337-351Crossref': [1044], '(286)': [1047], '15Robinson': [1050], '180-186Crossref': [1060], '(2296)': [1063], '16Cobb': [1066], 'Xu': [1068, 2546, 2619, 3344, 3521, 3864, 3884], 'Cheng': [1070], 'Ebert': [1072], 'Robinson': [1078], 'Adv.': [1080], 'Pharmacol.': [1081], '36:': [1083], '49-65Crossref': [1084], '(24)': [1087], 'itself': [1092], 'serine': [1098], 'residues': [1099, 3021], 'several': [1101, 2331, 4179, 4246], 'including': [1105, 2334, 2613], 'Raf': [1106], '(17Kolch': [1107], 'W.': [1108, 2711, 3047, 4349], 'Heidecker': [1109], 'Lloyd': [1111], 'Rapp': [1113, 1134, 3890], '349:': [1117], '426-428Crossref': [1118], '(382)': [1121], '18Kyriakis': [1124], 'App': [1126], 'H.': [1127, 1375, 1563, 1649, 2151, 2350, 2513, 2543, 2798, 2891, 3341, 3518, 3861], 'Zhang': [1128], 'X.': [1129, 1553, 1639, 2713], 'Brautigan': [1132], '1992;': [1139, 2059], '358:': [1140], '417-421Crossref': [1141], '(1002)': [1144], '19Moodie': [1147], 'Willumsen': [1149], 'Weber': [1151], 'Wolfman': [1153], '260:': [1157, 1204, 1424], '1658-1661Crossref': [1158], '(797)': [1161], 'Mos': [1164], '(20Posada': [1165], 'Yew': [1167], 'Ahn': [1169], 'Vande': [1171, 3940], 'Woude': [1172, 3941], 'Cooper': [1174], 'Mol.': [1176, 1680, 2098, 3370, 4294], '13:': [1180], '2546-2553Crossref': [1181], '(343)': [1184], '(MEKK1)': [1191], '(21Lange-Carter': [1192, 1412], 'Pleiman': [1194, 1414], 'Gardner': [1196, 1416], 'Blumer': [1198, 1418], 'K.': [1199, 1329, 1419, 1555, 1641, 1961, 2130, 2676, 2790, 2794, 2862, 3192], 'Ohnson': [1200, 1420], '315-319Crossref': [1205, 1425], '(886)': [1208, 1428], 'JNKs/SAPKs': [1213], 'stress-inducing': [1219], 'signals,': [1220], 'osmotic': [1223], 'heat': [1225], 'shock,': [1226], 'UV': [1227], 'light,': [1228], 'synthesis': [1230], 'inhibitors,': [1231], 'proinflammatory': [1233, 1611], 'It': [1305], 'has': [1306, 2319], 'recently': [1308], 'that': [1310, 1606, 2322, 2962, 4249, 4319], 'MKK4/SAPKK/JNKK/SEK1': [1311], 'phosphorylates': [1312], 'at': [1314, 1888, 3455, 3560, 3663, 3685, 3985, 4054], 'threonine': [1315], 'tyrosine,': [1317], 'thus': [1318, 2990], 'causing': [1319], '(22Sanchez': [1322], 'I.': [1323, 1354, 1913], 'Hughes': [1324], 'R.T.': [1325], 'Mayer': [1326], 'B.J.': [1327], 'Yee': [1328], 'Kyriakis': [1334, 1462, 2767], 'J.M.': [1335], 'Zon': [1336, 1464], 'L.I.': [1337], '794-798Crossref': [1341], '(926)': [1344], '23Derijard': [1347], 'Raingeaud': [1349], 'Han': [1355, 2617], '267:': [1363], '682-685Crossref': [1364], '(1424)': [1367], '24Lin': [1370], 'Minden': [1372], 'Martinetto': [1374], 'Claret': [1376, 2568], 'F.': [1377, 1381, 1724, 2121, 2731, 4185, 4233, 4259], 'Lange-Carter': [1378, 1437], 'Mercurio': [1380], 'Johnson': [1382, 1443, 1487, 1509, 1962], '286-290Crossref': [1389], '(717)': [1392], 'SEK1': [1395], 'MEKK1,': [1407], '-2,': [1408], '-3,': [1409], '-4': [1411], '25Minden': [1431], 'Lin': [1433, 2566], 'McMahon': [1435], '266:': [1449], '1719-1723Crossref': [1450], '(1019)': [1453], '26Yan': [1456], 'Deak': [1460], 'Templeton': [1468], '798-800Crossref': [1473], '(665)': [1476], '27Blank': [1479], 'Gerwins': [1481], 'Elliott': [1483], 'E.M.': [1484], 'Sather': [1485], 'G.L.': [1488, 1510], '271:': [1493, 1572, 1658, 1834, 3794], '5361-5368Abstract': [1494], '(207)': [1502], '28Gerwins': [1505], 'Blank': [1507], '272:': [1515, 1859, 2803, 2869], '8288-8295Abstract': [1516], '(215)': [1524], 'Tpl-2': [1527], '(29Salmeron': [1528], 'Carlile': [1532], 'Pappin': [1534], 'Narsimhan': [1536], 'Ley': [1538], '15:': [1543, 2751, 2774, 4298], '817-826Crossref': [1544], '(270)': [1547], 'MAPKKK5': [1551], '(30Wang': [1552], 'Diener': [1554, 1640], 'Jannuzzi': [1556, 1642], 'Trollinger': [1558, 1644], 'Tan': [1560, 1646, 2687, 2716], 'T.-H.': [1561, 1647], 'Lichenstein': [1562, 1648], 'Zukowski': [1564, 1650, 2685], 'Yao': [1566, 1652, 2689], '31607-31611Abstract': [1573, 1659], '(136)': [1581, 1667], 'However,': [1584], 'molecules': [1586], 'controlling': [1587], 'MEKK1': [1588], 'directly': [1589], 'currently': [1591], 'unknown.': [1592], 'function': [1594, 4307], 'cells': [1599, 2975, 3384, 3400, 3419, 3431, 3718, 3746], 'unclear,': [1601], 'but': [1602], 'recent': [1603], 'data': [1604], 'indicate': [1605], 'may': [1608, 1808, 2992], 'respond': [1609], '(interleukin-1,': [1613], 'TNF-α,': [1614], 'lipopolysaccharide)': [1615], 'environmental': [1617], '(osmotic': [1619], 'shock)': [1620], '(12Han': [1621], '30Wang': [1638], '31Raingeaud': [1670], 'Whitmarsh': [1672], 'A.J.': [1673], '1247-1255Crossref': [1685], '(1156)': [1688], '32Rouse': [1691], 'Trigon': [1695], 'Morange': [1697], 'Alonso-Llamazares': [1699], 'Zamanillo': [1701], 'Hunt': [1703], 'Nebreda': [1705], '78:': [1709, 1735], '1027-1037Abstract': [1710], '(1523)': [1716], '33Freshney': [1719], 'N.W.': [1720], 'Rawlinson': [1721], 'Guesdon': [1723], 'Jones': [1725], 'Cowley': [1727], 'Hsuan': [1729], 'Saklatvala': [1731], '1039-1049Abstract': [1736], '(786)': [1742], 'Pathways': [1745], 'regulating': [1746, 2528], 'ERK6': [1750], '(34Cuenda': [1751], 'Buee-Scherrer': [1755], 'V.': [1756, 4189, 4263], 'Goedert': [1757], '295-305Crossref': [1763], '(318)': [1766], 'appear': [1771], 'similar': [1774], 'those': [1776], 'ERK5,': [1800], 'oxidative': [1806], 'stress,': [1807], 'unique': [1811, 1878], 'redox-sensitive': [1812], 'distinct': [1814], 'from': [1815, 3033, 3063, 3158, 3273, 3548, 3974, 4141, 4151, 4159], 'other': [1816, 4180], '(35Abe': [1820, 3780], 'Kusuhara': [1822, 3782], 'Berk': [1826, 1853, 3786], 'B.C.': [1827, 1854, 3787], '16586-16590Abstract': [1835, 3795], '(388)': [1843, 3803], 'Scholar,36Abe': [1845], 'Takahashi': [1847], 'Ishida': [1849], '20389-20394Abstract': [1860], '(257)': [1868], 'unexpected': [1872], 'diversity': [1873], 'cells.': [1881], 'budding': [1884, 2145], 'yeast': [1885], 'cerevisiae,': [1887], 'least': [1889], 'six': [1890, 3268], 'pathways': [1892, 2535], '(37Davis': [1896], 'Trends': [1898, 1964, 1996, 2270], 'Biochem.': [1899, 1965, 3196], '19:': [1902, 1968, 3374], '470-473Abstract': [1903], '(929)': [1909], '38Herskowitz': [1912], '80:': [1916], '187-197Abstract': [1917], '(875)': [1923], 'They': [1926], 'regulate': [1927], 'processes,': [1930], 'mating': [1933, 2045, 2204], 'invasive': [1935], 'growth,': [1936], 'wall': [1938], 'integrity,': [1939], 'high': [1944, 2945], 'osmolarity': [1945], '(39Ammerer': [1946], 'Genet.': [1950, 1997, 2100], 'Dev.': [1951, 2132, 2159, 2719], '4:': [1953], '90-95Crossref': [1954], '(71)': [1957], '40Blumer': [1960], '236-240Abstract': [1969], '(433)': [1975], '41Levin': [1978], 'Errede': [1980], '7:': [1987, 2274], '197-202Crossref': [1988], '(218)': [1991], '42Neiman': [1994], 'A.M.': [1995], '390-394Abstract': [2000], '(86)': [2006], 'Based': [2009, 2252], 'epistasis': [2011], 'experiments,': [2012], 'act': [2022], 'module': [2027], 'consisting': [2028], 'STE11,': [2034], 'STE7,': [2038], 'FUS3/KSS1': [2042], '(43Leberer': [2047], 'Dignard': [2049, 2088], 'Harcus': [2051, 2090], 'Thomas': [2053, 2096], 'Whiteway': [2055, 2094], '11:': [2060], '4815-4824Crossref': [2061], '(349)': [2064], '44Ramer': [2067], '90:': [2079], '452-456Crossref': [2080], '(173)': [2083], '45Leberer': [2086], 'Hougan': [2092], 'Gen.': [2099], '241:': [2102], '241-254Crossref': [2103], '(52)': [2106], 'Additional': [2109], 'STE20-like': [2112, 2180, 2258, 2839, 2857, 2999], 'identified,': [2116, 4364], 'Cla4': [2119], '(46Cvrckova': [2120], 'De': [2122], 'Virgilio': [2123], 'Manser': [2125], 'Pringle': [2127], 'Nasmyth': [2129], 'Genes': [2131, 2158, 2718], '1817-1830Crossref': [2135], '(313)': [2138], 'involved': [2143], 'cytokinesis,': [2147], 'SPS1': [2149], '(47Friesen': [2150], 'Lunz': [2152], 'Doyle': [2154], 'Segall': [2156], '2162-2175Crossref': [2162], '(109)': [2165], 'required': [2170, 2198], 'for': [2171, 2199, 3087, 3318, 3557, 3666, 3688, 3708, 3765, 3768, 3775, 3778, 3810, 3813, 3850, 3913, 3988, 4057, 4171], 'late': [2172], 'events': [2173], 'sporulation.': [2175], 'fission': [2177], 'yeast,': [2178], 'Shk1': [2182], 'forms': [2183], 'complex': [2185], 'with': [2186, 2499, 3093, 3393, 3409, 3434, 3450, 3554, 3566, 3580, 3592, 3604, 3721, 3733, 3759, 3821, 4071, 4102, 4323], 'Cdc42': [2187, 2507], 'functional': [2190], 'interaction': [2191], 'Shk1,': [2193], 'Cdc42,': [2194], 'Ras1': [2196], 'normal': [2200], 'morphology': [2202], '(48Marcus': [2205], 'Polverino': [2207], 'Chang': [2209], 'Wigler': [2215], '92:': [2225], '6180-6184Crossref': [2226], '(135)': [2229], 'last': [2234], 'few': [2235], 'years,': [2236], 'large': [2238], 'number': [2239, 2609], 'closely': [2243], 'identified.': [2251], 'structure,': [2255], '(49Sells': [2266], 'Chernoff': [2268, 2370, 2432, 2453, 2820, 2844], '162-167Abstract': [2275], '(266)': [2281], 'Scholar):': [2283], 'subfamily,': [2286, 2305], 'containing': [2287, 3016, 3216, 3249, 3461, 3582, 3638, 4017, 4047], 'domain)': [2296], 'domain;': [2301], 'contains': [2307], 'lacks': [2313], 'Recently,': [2317], 'comprises': [2324, 2606], 'composed': [2329], 'isoforms,': [2333], 'rat': [2336], 'mouse': [2338, 4108], 'p21-activated': [2339], 'p65PAK': [2342], 'mPAK-3': [2344], '(50Manser': [2345, 2508], 'Leung': [2347, 2402, 2510], 'Salihuddin': [2349, 2512], 'Zhao': [2351, 2400, 2514], 'Z.S.': [2352, 2401, 2515], 'Lim': [2353, 2408, 2516], '367:': [2357, 2520], '40-46Crossref': [2358, 2521], '(1323)': [2361, 2524], '51Bagrodia': [2364], 'Taylor': [2366], 'S.J.': [2367], 'Creasy': [2368], 'C.L.': [2369, 2819, 2843], 'Cerione': [2372], 'R.A.': [2373], '22731-22737Abstract': [2379], '(334)': [2387], 'counterparts,': [2393], 'hPAK65': [2394], '(hPAK2)': [2395], '(52Manser': [2396], 'Chong': [2398], 'Michael': [2404], 'Hall': [2406, 2590], '25070-25078Abstract': [2415], '(209)': [2423], '53Knaus': [2426], 'U.G.': [2427, 2448], 'Morris': [2428, 2449], 'Dong': [2430, 2451], 'H.J.': [2431, 2452], 'Bokoch': [2434, 2455], 'G.M.': [2435, 2456], '269:': [2438, 2459, 2594, 2666, 3898], '221-223Crossref': [2439, 2460], '(365)': [2442, 2463], 'Scholar)': [2444, 2634, 2650, 2705, 2727, 2757, 2780, 2814, 2837, 2855, 2880, 2908, 3204], 'hPAK1': [2446], '(53Knaus': [2447], '54Brown': [2466], 'Stowers': [2468], 'Baer': [2470], 'Trejo': [2472], 'Coughlin': [2474], 'Chant': [2476], '6:': [2481], '598-605Abstract': [2482], '(229)': [2490], 'all': [2495], 'able': [2496], 'interact': [2498], 'p21': [2502], 'thereby': [2527], '(55Coso': [2536, 3334, 3511, 3854], 'O.A.': [2537, 3335, 3512, 3855], 'Yu': [2538, 3336, 3513, 3856], 'Chiariello': [2540, 3338, 3364, 3515, 3858], 'Teramoto': [2542, 3340, 3517, 3860], 'Crespo': [2544, 3342, 3519, 3862], 'Miki': [2548, 3066, 3346, 3523, 3866, 4192, 4266], 'Gutkind': [2550, 3348, 3368, 3525, 3868, 3892], 'J.S.': [2551, 3349, 3369, 3526, 3869, 3893], '81:': [2554, 2576, 3352, 3529, 3872], '1137-1146Abstract': [2555, 3353, 3530, 3873], '(1574)': [2561, 3359, 3536, 3879], '56Minden': [2564], 'F.X.': [2569], 'Abo': [2570], '1147-1157Abstract': [2577], '(1450)': [2583], '57Olson': [2586], 'Ashworth': [2588], '1270-1272Crossref': [2595], '(1063)': [2598], 'growing': [2608], 'mNIK': [2614], '(58Su': [2615], 'Y.C.': [2616], 'Skolnik': [2623], 'E.Y.': [2624], '1279-1290Crossref': [2629], '(221)': [2632], '(Nck-interacting': [2635], 'kinase),': [2636, 2816], 'hKHS': [2637], '(59Tung': [2638], 'R.M.': [2639], 'Blenis': [2640, 2863], 'Oncogene.': [2642, 3048, 4239, 4350], '14:': [2644, 3050, 4352], '653-659Crossref': [2645], '(68)': [2648, 4302], '(kinase': [2651], 'homologous': [2652], 'SPS1/STE20),': [2654], 'hGCK': [2655], '(60Katz': [2656], 'Whalen': [2658], 'Kehrl': [2660], '16802-16809Abstract': [2667], 'hGLK': [2674], '(61Diener': [2675], 'Wang': [2677, 2712, 2890], 'X.S.': [2678], 'Chen': [2679], 'Meyer': [2681, 2714], 'C.F.': [2682], 'Keesler': [2683], 'T.H.': [2688], '94:': [2699], '9687-9692Crossref': [2700], '(122)': [2703], '(GCK-likekinase),': [2706], 'hHPK1': [2707], '(62Hu': [2708], 'Qiu': [2710], '10:': [2721, 4241], '2251-2264Crossref': [2722], '(199)': [2725], 'mHPK1': [2729], '(63Kiefer': [2730], 'Tibbles': [2732], 'Anafi': [2734], 'Janssen': [2736], 'Zanke': [2738], 'Lassam': [2740], 'Pawson': [2742], 'Iscove': [2746], '7013-7025Crossref': [2752], '(203)': [2755], '(hematopoietic': [2758], 'progenitorkinase-1),': [2759], 'hSOK-1': [2760], '(64Pombo': [2761], 'C.M.': [2762], 'Bonventre': [2763], 'J.V.': [2764], 'Molnar': [2765], 'Force': [2769], '4537-4546Crossref': [2775], '(137)': [2778], '(STE20/oxidant': [2781], 'responsekinase-1),': [2783], 'mLOK': [2784], '(65Kuramochi': [2785], 'Moriguchi': [2787], 'Kuida': [2789], 'Endo': [2791], 'Semba': [2793], 'Nishida': [2795], 'Karasuyama': [2797], '22679-22684Abstract': [2804], '(61)': [2812], '(lymphocyte-oriented': [2815], 'hMST1': [2817], '(66Creasy': [2818], '21695-21700Abstract': [2827], '(176)': [2835], '(mammalian': [2838, 2856], 'kinase-1),': [2840], 'hMST2': [2841], '(67Creasy': [2842], 'Gene': [2846], '(Amst.).': [2847], '167:': [2849], '303-306Crossref': [2850], '(119)': [2853], 'kinase-2)': [2858], 'hMST3': [2860], '(68Schinkmann': [2861], '28695-28703Abstract': [2870], '(94)': [2878], '(ammalian': [2881], 'E20-like': [2882], 'kinase-3),': [2883], 'hKRS1': [2885], '(69Taylor': [2888], 'Erikson': [2892], '10099-10104Crossref': [2903], '(141)': [2906], '(kinases': [2909], 'responsive': [2910], 'tostress).': [2911], 'study,': [2914], 'describe': [2916], 'isolation': [2918], 'designatedJNK/SAPK-inhibitory': [2925], '(JIK),': [2927], 'shares': [2931, 2944], 'similarity': [2932], 'kinases.': [2939], 'non-catalytic': [2942, 3160], 'homology': [2946], 'Caenorhabditis': [2949], 'elegans': [2950], 'putative': [2951], 'named': [2954], 'SULU,': [2955], 'unknown': [2957], 'Interestingly,': [2959], 'pathway;': [2969], 'rather,': [2970], 'overexpression': [2972], 'COS7': [2974, 3383, 3418, 3430, 3717, 3745], 'leads': [2976], 'activity,': [2988], 'reduced': [3004], 'stimulation': [3006], 'surface': [3010], 'receptor.': [3011], 'A': [3012, 3074], 'GST': [3013, 4336], 'fusion': [3014, 3185, 3834], 'eps8-SH3': [3017], '(amino': [3019], 'acid': [3020, 3924, 4053, 4394], '531–591)': [3022], 'used': [3024, 3086, 3153, 3206], 'screen': [3026], 'pCEV-LAC': [3028], 'bacterial': [3029], 'expression': [3030, 3240, 3247, 3256, 3306, 3316, 4332], 'library': [3031, 3058, 4333], 'constructed': [3032], 'embryonic': [3035, 4329], 'fibroblast': [3036, 4330], 'M426': [3037, 4331], 'mRNAs,': [3038], 'described': [3040, 3190, 3333, 3510, 3846, 3929], 'previously': [3041], '(70Biesova': [3042, 4344], 'Piccoli': [3044, 4346], 'Wong': [3046, 4194, 4230, 4268, 4285, 4348], '233-241Crossref': [3051, 4353], '(90)': [3054, 4356], 'kind': [3061], 'gift': [3062], 'Dr.': [3064], 'Toru': [3065], '(71Miki': [3067], 'Aaronson': [3069, 3943], 'Hardy': [3071], 'K.G.': [3072], 'Plasmid:': [3073], 'Practical': [3075], 'Approach.': [3076], 'Oxford': [3077], 'University': [3078], 'Press,': [3079], 'New': [3080], 'York1993:': [3081], '177-196Google': [3082], 'DNA': [3084, 3157], 'probes': [3085], 'Northern': [3088, 3117, 3127], 'blot': [3089, 3118, 3710, 3915], 'analysis': [3090, 3119, 3711, 3916, 3925], 'were': [3091, 3112, 3152, 3227, 3279, 3310, 3385, 3401, 3432, 3448, 3507, 3545, 3564, 3670, 3683, 3706, 3719, 3747, 3754, 3819, 3911, 3955, 4069, 4078, 4087, 4112, 4139, 4149, 4363], 'labeled': [3092], '[α-32P]dCTP': [3094], 'using': [3095, 3712, 3829, 4123, 4334], 'random': [3097, 3113], 'priming': [3098], 'kit': [3099], '(Stratagene).': [3100], 'cDNA': [3103, 3214, 4361, 4374], '(nucleotides': [3104], '1100–2800)': [3105], 'glyceraldehyde': [3109], '3′-phosphate': [3110], 'dehydrogenase': [3111], 'primed': [3114], '(Stratagene),': [3115], 'performed': [3121, 3132, 3421, 3508, 3927, 4043], 'commercial': [3123], 'multiple': [3125], 'tissue': [3126], 'blots': [3128], '(CLONTECH).': [3129], 'Hybridization': [3130], 'recommended': [3134], 'manufacturer.': [3137], 'Two': [3138, 3442], 'oligonucleotide': [3139], 'primers,': [3140], '5′-CCGCGTGGATCCATGTCAGGTTATAAGCGGATGCGGCG-3′': [3141], '5′-TGAATTAAGCTTTCATCTGTAGTCCTCCTTAGGAAAATC-3′,': [3143], 'corresponding': [3144, 4104], 'amino': [3147, 3264, 3269, 4067], 'acids': [3148, 3265, 3270, 4068, 4077], '461–469': [3149], '891–898,': [3151], 'amplify': [3155], 'region': [3161, 4222], '(clone': [3164, 4135], '74).': [3165], 'resulting': [3167], 'fragment': [3168], 'cloned': [3170], 'frame': [3172, 4397], 'BamHI': [3175], 'andHindIII': [3176], 'sites': [3177, 3233, 3301], 'pGEX-KG': [3179], 'vector': [3180, 3248], '(Amersham': [3181, 3573], 'Pharmacia': [3182, 3574, 4121], 'Biotech).': [3183], 'GST-JIK': [3184], 'purified': [3188], '(72Guan': [3191], 'Anal.': [3195], '192:': [3198], '262-267Crossref': [3199], '(1662)': [3202], 'raise': [3208], 'polyclonal': [3209, 4144], 'antibodies': [3210], 'rabbit.': [3212], 'BamHI-EcoRI': [3213], 'fragments': [3215], 'either': [3217], 'entire': [3219], 'coding': [3220], 'sequence': [3221, 4383], 'JIK(A181': [3225], 'F183)': [3226], 'amplified': [3228], 'introduced': [3230, 3280], 'BglII-EcoRI': [3232], 'pCEFL': [3235, 3238, 3242], 'HA': [3236, 3274], 'AU5': [3239], 'vectors.': [3241, 3307], 'modified': [3245, 3389, 3405], 'pcDNAIII': [3246], 'elongation': [3251], 'factor-1': [3252], 'promoter': [3253], 'driving': [3254], 'in-frame': [3259], 'tag': [3261], 'nine': [3263], '(YPYDVPDYA)': [3266], '(TDFYLK)': [3271], 'derived': [3272], 'AU5,': [3276], 'respectively.': [3277, 3428, 4025], 'Mutations': [3278], 'pBluescriptII': [3282], 'SK-JIK': [3283], 'polymerase': [3285], 'chain': [3286], 'reaction': [3287, 3606, 3636], '(QuickChangeTM': [3288], 'mutagenesis': [3289], 'kit;': [3290], 'Stratagene)': [3291], 'according': [3292], "manufacturer's": [3295], 'instructions': [3296], 'subcloned': [3298], 'theBglII-EcoRI': [3300], 'pCEFL-HA': [3303], 'pCEFL-AU5': [3305], 'mutations': [3309], 'confirmed': [3311], 'automated': [3313], 'sequencing.': [3314], 'vectors': [3317], 'pCDNA3-HA-JNK,': [3319], 'pCDNA3-HA-ERK2,': [3320, 3725], 'pCEFL-HA-p38,': [3321, 3727], 'pCEFL-HA-ERK5,': [3322, 3729], 'pCEFL-HA-ERK6,': [3323, 3726], 'pCEFL-HA-SAPK4,': [3324, 3728], 'pCEFL-AU5-Rac1QL,': [3325], 'pCEFL-AU5-Cdc42QL,': [3326], 'pCEFL-AU5-MLK3,': [3327], 'pCEV29-MEKK1': [3329], 'already': [3332], '73Marinissen': [3362], 'Pallante': [3366], '1999;': [3373], '4289-4301Crossref': [3375], '(192)': [3378], 'C33A': [3381, 3416], 'grown': [3386, 3402], "Dulbecco's": [3388, 3404], "Eagle's": [3390, 3406], 'medium': [3391, 3407], 'supplemented': [3392, 3408], '10%': [3394, 3410, 4051], '(v/v)': [3395, 3411], 'fetal': [3396], 'bovine': [3397], 'serum.': [3398, 3413], 'NIH-3T3': [3399], 'calf': [3412], 'Transfection': [3414], 'calcium': [3423], 'phosphate': [3424], 'DEAE-dextran': [3426], 'methods,': [3427], 'Subconfluent': [3429, 3716], 'transfected': [3433, 3744], '10': [3435, 3467, 3807, 4013], 'μg': [3436, 3654, 3723, 3735, 3831, 3838], 'pCEFL-HA,': [3438], 'pCEFL-HA-JIK,': [3439], 'pCEFL-HA-JIK(A181F183).': [3441], 'days': [3443], 'transfection,': [3445], 'transfectants': [3447], 'washed': [3449, 3577, 3820], 'cold': [3451, 3650, 3822], 'PBS': [3452, 3581, 3823], 'lysed': [3454], '4': [3456, 3561, 3653, 3837], '°C': [3457, 3665, 3687, 3987], 'buffer': [3460, 3607, 3637, 4046], '20': [3462, 3492, 3496, 3613, 3616, 3647, 3776, 3811], 'mm': [3463, 3468, 3473, 3476, 3482, 3485, 3489, 3588, 3594, 3609, 3614, 3619, 3623], 'Hepes': [3464], '(pH': [3465, 3470, 3596], '7.5),': [3466], 'EGTA': [3469], '8),': [3471], '2.5': [3472], 'MgCl2,': [3474, 3615], 'DTT,': [3477], '1%': [3478, 3583, 4048], 'Nonidet': [3479, 3584], 'P-40,': [3480], '40': [3481], 'β-glycerophosphate,': [3483], 'sodium': [3486, 3589, 3620], 'orthovanadate,': [3487, 3621], 'phenylmethylsulfonyl': [3490], 'fluoride,': [3491], 'μg/ml': [3493, 3497, 3808], 'aprotinin,': [3494], 'leupeptin.': [3498], 'immunoprecipitation': [3500], 'procedure': [3501], 'subsequent': [3504], 'assay': [3506, 3853], 'Briefly,': [3539], 'epitope-tagged': [3541], 'JIK(A181F183)': [3544], 'respectively': [3546], 'immunoprecipitated': [3547], 'cleared': [3550], 'lysates': [3551], 'incubation': [3553, 3662], 'anti-HA': [3555, 3704, 3907, 4134], '(12CA5)': [3556], 'h': [3559], '°C.': [3562], 'Immunocomplexes': [3563, 4111], 'recovered': [3565], 'aid': [3568], 'Gamma-Bind': [3570], 'Sepharose': [3571], 'beads': [3572], 'Biotech)': [3575, 4122], 'three': [3578], 'times': [3579], 'P-40': [3585], 'othovanadate,': [3590], 'once': [3591, 3603], '100': [3593, 3760], 'Tris': [3595], '7.5)': [3597], '0.5': [3599], 'm': [3600], 'LiCl,': [3601], '(25': [3608], 'Hepes,': [3610], 'pH': [3611], '7.5,': [3612], 'mmβ-glycerophosphate,': [3617], 'DTT).': [3624], 'determined': [3628], 'resuspension': [3630], '30': [3632, 3664, 3667], 'μl': [3633, 3677, 4014, 4027], 'μCi': [3640], '(4500': [3641], 'Ci/mmol)': [3642], '[γ-32P]ATP': [3644], 'per': [3645], 'reaction,': [3646], 'μm': [3648, 3773], 'ATP,': [3651], 'substrate.': [3660], 'After': [3661, 3741], 'min,': [3668, 3690], 'reactions': [3669], 'terminated': [3671], 'addition': [3674], '15': [3676, 3766], '5×': [3679], "Laemmli's": [3680], 'buffer.': [3681], 'Samples': [3682], 'heated': [3684], '95': [3686], '5': [3689, 3830], 'analyzed': [3691, 4088], 'SDS': [3693], '12.5%': [3696], 'gels,': [3698], 'visualized': [3700, 4070, 4113], 'autoradiography.': [3702, 4081], 'Parallel': [3703, 3906], 'immunoprecipitates': [3705, 3910, 4086], 'processed': [3707, 3912], 'Western': [3709, 3914, 4090], 'anti-JIK-specific': [3714], 'antiserum.': [3715], 'cotransfected': [3720], 'pCDNA3-HA-JNK': [3731], 'pCEFL-AU5,': [3737], 'pCEFL-AU5-JIK,': [3738], 'pCEFL-AU5-JIK(A181F183).': [3740], 'days,': [3743], 'cultured': [3748], 'overnight': [3749], 'serum-free': [3751], 'medium.': [3752], 'Cells': [3753, 3818], 'left': [3755], 'untreated': [3756], 'stimulated': [3758], 'ng/ml': [3761], '(Upstate': [3763], 'Biotechnology)': [3764], 'min': [3767, 3777, 3812], 'ERK': [3769], 'JNK,': [3771], '200': [3772], 'H2O2': [3774], 'anisomycin': [3809], 'SAPK4.': [3817], 'subjected': [3825], 'assay,': [3828], 'GST-ATF2(96)': [3833], 'substrate,': [3844], 'method': [3849], 'autophosphorylation': [3852], '74Crespo': [3882], 'Daniotti': [3886], 'Troppmair': [3888], 'U.R.': [3891], '21103-21109Abstract': [3899], 'anti-AU5': [3909, 4138], 'using,': [3917], 'MAPK-': [3919], 'JIK-specific': [3921], 'antisera.': [3922, 4130], 'Phosphoamino': [3923, 4076], '(75Bottaro': [3930], 'Rubin': [3932], 'Faletto': [3934], 'Chan': [3936], 'Kmiecik': [3938], '251:': [3947], '802-804Crossref': [3948], '(2136)': [3951], 'Phosphoproteins': [3954], 'separated': [3956], 'SDS-PAGE,': [3958, 4093], 'transferred': [3959, 4094], 'electrophoretically': [3960], 'Immobilon': [3962, 4096], 'P': [3963, 4097], 'membranes': [3964, 4098], '(Millipore),': [3965, 4099], 'autoradiographed.': [3967], 'band': [3969], 'interest': [3971], 'excised': [3973], 'membrane,': [3976], 'phosphoprotein': [3979], 'hydrolyzed': [3981, 3992], '6n': [3983], 'HCl': [3984], '110': [3986], '90': [3989], 'min.': [3990, 4059], 'sample': [3993, 4030], 'diluted': [3995], 'ml': [3998], 'water,': [4000], 'frozen': [4001], 'dry': [4003], 'ice,': [4004], 'dried': [4005], 'centrifugation': [4007], 'under': [4008], 'vacuum,': [4009], 'resuspended': [4011], 'water': [4016], 'mg/ml': [4019], 'phosphotyrosine,': [4020], 'phosphoserine,': [4021], 'phosphothreonine': [4023], 'standard,': [4024], 'then': [4032, 4063], 'spotted': [4033], 'onto': [4034], 'cellulose': [4036], 'thin': [4037], 'layer': [4038], 'chromatography': [4039], 'plate.': [4040], 'Electrophoresis': [4041], 'pyridine': [4049], 'acetic': [4052], '800': [4055], 'V': [4056], '75': [4058], 'plates': [4061], 'air-dried,': [4064], '0.25%': [4072], 'ninhydrin': [4073], 'acetone.': [4075], 'Anti-HA,': [4082], 'anti-AU5,': [4083], 'anti-JIK': [4085], 'blotting': [4091], 'immunoblotted': [4101], 'rabbit': [4105], 'antiserum': [4106], 'monoclonal': [4109, 4132], 'antibody.': [4110], 'enhanced': [4115], 'fluoroluminescence': [4116], 'detection': [4117], '(Vistra': [4118], 'ECF,': [4119], 'Amersham': [4120], 'alkaline': [4124], 'phosphatase-linked': [4125], 'goat': [4126], 'anti-rabbit': [4127], 'anti-mouse': [4129], 'Mouse': [4131], 'antibodies,': [4133], '12CA5)': [4136], 'purchased': [4140, 4150, 4158], 'BABCO.': [4142], 'Rabbit': [4143], 'anti-JNK1,': [4145], 'anti-ERK2,': [4146], 'anti-p38': [4148], 'Santa': [4152], 'Cruz': [4153], 'Biotechnology,': [4154], 'Inc.': [4155], 'Anti-ERK5': [4156], 'Stressgen.': [4160], 'Eps8': [4161], 'SH3': [4164, 4337], 'domain-containing': [4165], 'substrate': [4170], '(EGFR)': [4177], '(76Fazioli': [4184, 4258], 'Minichiello': [4186, 4260], 'Matoska': [4188, 4262], 'Castagnino': [4190, 4264], 'W.T.': [4195, 4231, 4269, 4286], 'Di': [4196, 4236, 4270, 4291], 'Fiore': [4197, 4237, 4271, 4292], 'P.P.': [4198, 4238, 4272, 4293], '12:': [4202, 4276], '3799-3808Crossref': [4203, 4277], '(158)': [4206, 4280], 'site': [4211], 'eps8': [4213, 4250, 4340], 'EGFR': [4216], 'mapped': [4218], 'juxtamembrane': [4221], '(77Castagnino': [4226], 'Biesova': [4228], 'Fazioli': [4232], 'Gill': [4234], 'G.N.': [4235], '723-729PubMed': [4242], 'Although': [4245], 'observations': [4247], 'suggest': [4248], 'plays': [4251], 'critical': [4253], 'role': [4254], 'mitogenic': [4256], '78Matoskova': [4283], 'Salcini': [4287], 'A.E.': [4288], 'Pelicci': [4289], 'P.G.': [4290], '3805-3812Crossref': [4299], 'still': [4309], 'clearly': [4311], 'understood.': [4312], 'As': [4313], 'approach': [4315], 'identify': [4317], 'associate': [4321], 'physically': [4322], 'eps8,': [4324], 'screened': [4326], 'probe': [4343], 'Several': [4359], 'overlapping': [4360], 'clones': [4362], 'longest': [4366], 'clone': [4370, 4386, 4409], '74–10,': [4371], 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