Publication Information

{'id': 'https://openalex.org/W2052943010', 'doi': 'https://doi.org/10.1046/j.1471-4159.2000.0741999.x', 'title': 'Characteristics of the Calcium‐Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria', 'display_name': 'Characteristics of the Calcium‐Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria', 'publication_year': 2000, 'publication_date': '2000-05-01', 'ids': {'openalex': 'https://openalex.org/W2052943010', 'doi': 'https://doi.org/10.1046/j.1471-4159.2000.0741999.x', 'mag': '2052943010', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10800943'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1471-4159.2000.0741999.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2000.0741999.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2000.0741999.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059402016', 'display_name': 'Tibor Kristián', 'orcid': 'https://orcid.org/0000-0002-1804-8999'}, 'institutions': [{'id': 'https://openalex.org/I4210104115', 'display_name': "Queen's Medical Center", 'ror': 'https://ror.org/016gbn942', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104115']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tibor Kristián', 'raw_affiliation_strings': ["Center for the Study of Neurological Disease, The Queen's Medical Center, Honolulu, Hawaii 96813, USA."], 'affiliations': [{'raw_affiliation_string': "Center for the Study of Neurological Disease, The Queen's Medical Center, Honolulu, Hawaii 96813, USA.", 'institution_ids': ['https://openalex.org/I4210104115']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011170921', 'display_name': 'Jürg Gertsch', 'orcid': 'https://orcid.org/0000-0003-0978-1555'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jeff Gertsch', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016617654', 'display_name': 'Timothy E. Bates', 'orcid': 'https://orcid.org/0000-0001-5955-0259'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Timothy E. Bates', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113475821', 'display_name': 'Bo K. Siesjö', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bo K. Siesjö', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.898, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 120, 'citation_normalized_percentile': {'value': 0.852214, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '74', 'issue': '5', 'first_page': '1999', 'last_page': '2009'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.76617527}, {'id': 'https://openalex.org/C13591479', 'wikidata': 'https://www.wikidata.org/wiki/Q6881880', 'display_name': 'Mitochondrial permeability transition pore', 'level': 4, 'score': 0.7468569}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.60921746}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5812478}, {'id': 'https://openalex.org/C4141045', 'wikidata': 'https://www.wikidata.org/wiki/Q83183', 'display_name': 'Depolarization', 'level': 2, 'score': 0.569209}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.5434222}, {'id': 'https://openalex.org/C120882062', 'wikidata': 'https://www.wikidata.org/wiki/Q28352', 'display_name': 'Permeability (electromagnetism)', 'level': 3, 'score': 0.4294808}, {'id': 'https://openalex.org/C181911157', 'wikidata': 'https://www.wikidata.org/wiki/Q389844', 'display_name': 'Membrane potential', 'level': 2, 'score': 0.41265357}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35352343}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20159209}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.11014843}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.08504921}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008929', 'descriptor_name': 'Mitochondria, Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008929', 'descriptor_name': 'Mitochondria, Heart', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008931', 'descriptor_name': 'Mitochondria, Muscle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008931', 'descriptor_name': 'Mitochondria, Muscle', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010539', 'descriptor_name': 'Permeability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010539', 'descriptor_name': 'Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014451', 'descriptor_name': 'Ubiquinone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014451', 'descriptor_name': 'Ubiquinone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1471-4159.2000.0741999.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2000.0741999.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10800943', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1471-4159.2000.0741999.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2000.0741999.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.43, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1489283017', 'https://openalex.org/W1500217596', 'https://openalex.org/W1528505919', 'https://openalex.org/W1542197083', 'https://openalex.org/W1581717960', 'https://openalex.org/W1781335978', 'https://openalex.org/W1851055496', 'https://openalex.org/W1887119011', 'https://openalex.org/W1964826110', 'https://openalex.org/W1972681977', 'https://openalex.org/W1972733192', 'https://openalex.org/W1981053322', 'https://openalex.org/W1981705617', 'https://openalex.org/W1984420703', 'https://openalex.org/W1995628673', 'https://openalex.org/W1996907401', 'https://openalex.org/W2003117360', 'https://openalex.org/W2007005170', 'https://openalex.org/W2008117638', 'https://openalex.org/W2008757109', 'https://openalex.org/W2015583712', 'https://openalex.org/W2016139827', 'https://openalex.org/W2017546932', 'https://openalex.org/W2029404346', 'https://openalex.org/W2031702150', 'https://openalex.org/W2035117212', 'https://openalex.org/W2045698094', 'https://openalex.org/W2052607700', 'https://openalex.org/W2053534803', 'https://openalex.org/W2053836019', 'https://openalex.org/W2054712846', 'https://openalex.org/W2054989425', 'https://openalex.org/W2063772445', 'https://openalex.org/W2068296439', 'https://openalex.org/W2074036818', 'https://openalex.org/W2074330066', 'https://openalex.org/W2075874065', 'https://openalex.org/W2092146469', 'https://openalex.org/W2092510248', 'https://openalex.org/W2093491661', 'https://openalex.org/W2095212152', 'https://openalex.org/W2096426937', 'https://openalex.org/W2097307735', 'https://openalex.org/W2131461587', 'https://openalex.org/W2142700343', 'https://openalex.org/W2143302994', 'https://openalex.org/W2229772813', 'https://openalex.org/W2241448607'], 'related_works': ['https://openalex.org/W4225596112', 'https://openalex.org/W2804831488', 'https://openalex.org/W2371822608', 'https://openalex.org/W2060662231', 'https://openalex.org/W2055246478', 'https://openalex.org/W2039760353', 'https://openalex.org/W2026124448', 'https://openalex.org/W1991683799', 'https://openalex.org/W1535995443', 'https://openalex.org/W153215394'], 'abstract_inverted_index': {'Abstract:': [0], 'The': [1, 41, 175, 259, 284, 302], 'objective': [2], 'of': [3, 12, 43, 119, 130, 161, 199, 204, 223, 231, 243, 261, 273, 299, 309, 319], 'the': [4, 10, 106, 134, 137, 142, 150, 172, 195, 210, 224, 232, 238, 244, 249, 254, 271, 310, 326, 331], 'present': [5], 'study': [6], 'was': [7, 155, 168, 178, 197], 'to': [8, 16, 22, 28, 113, 140, 217, 330], 'assess': [9], 'capacity': [11, 112, 242], 'nonsynaptic': [13], 'brain': [14, 107, 289, 311], 'mitochondria': [15, 108, 138, 290], 'accumulate': [17, 114], 'Ca': [18, 24, 48, 115, 125, 143, 152, 162, 212, 239, 250, 256], '2+': [19, 25, 49, 96, 116, 126, 144, 153, 163, 213, 240, 251, 257], 'when': [20, 76, 123, 270], 'subjected': [21], 'repeated': [23, 124], 'loads,': [26], 'and': [27, 51, 80, 94, 185, 316, 333], 'explore': [29], 'under': [30], 'what': [31], 'conditions': [32], 'a': [33, 66, 70, 86, 110, 158, 165, 181, 221, 297, 307], 'mitochondrial': [34, 120, 225, 337], 'permeability': [35], 'transition': [36], '(MPT)': [37], 'pore': [38, 53], 'is': [39, 69, 207, 305], 'assembled.': [40], 'effects': [42, 260], 'cyclosporin': [44], 'A': [45], '(CsA)': [46], 'on': [47, 78], 'accumulation': [50], 'MPT': [52, 72, 219, 233], 'assembly': [54], 'were': [55, 263], 'compared': [56], 'with': [57, 60], 'those': [58, 294], 'obtained': [59], 'ubiquinone': [61], '0': [62, 64, 267, 275], '(Ub': [63], '),': [65, 100], 'quinone': [67], 'that': [68, 167, 200, 209, 288, 306], 'stronger': [71], 'blocker': [73, 230], 'than': [74], 'CsA,': [75, 227], 'tested': [77], 'muscle': [79], 'liver': [81], 'mitochondria.': [82, 245], 'When': [83], 'suspended': [84], 'in': [85, 147, 220], 'solution': [87], 'containing': [88], 'phosphate': [89], '(2': [90], 'm': [91, 98], 'M': [92, 99, 279], ')': [93], 'Mg': [95], '(1': [97], 'but': [101, 269, 324], 'no': [102], 'ATP': [103], 'or': [104], 'ADP,': [105], 'had': [109], 'limited': [111], '(210': [117], 'nmol/mg': [118, 129], 'protein).': [121], 'Furthermore,': [122], 'pulses': [127], '(40': [128], 'protein': [131], 'each)': [132], 'saturated': [133], 'uptake': [135], 'system,': [136], 'failed': [139], 'release': [141, 160, 166, 177, 252], 'accumulated.': [145], 'However,': [146, 193, 246], 'each': [148], 'instance,': [149], 'first': [151, 211, 255], 'pulse': [154, 214], 'accompanied': [156, 179], 'by': [157, 180, 186, 190, 265], 'moderate': [159], ',': [164, 268, 280], 'not': [169, 325], 'observed': [170, 201], 'during': [171], 'subsequent': [173], 'pulses.': [174], 'initial': [176], 'relatively': [182], 'marked': [183], 'depolarization,': [184], 'swelling,': [187], 'as': [188, 194], 'assessed': [189], 'light‐scattering': [191], 'measurements.': [192], 'swelling': [196], '<50%': [198], 'following': [202], 'addition': [203], 'alamethicin,': [205], 'it': [206, 281], 'concluded': [208], 'gives': [215], 'rise': [216], 'an': [218, 228, 320], 'subfraction': [222], 'population.': [226], 'avid': [229], 'pore,': [234], 'only': [235], 'marginally': [236], 'increased': [237], '‐sequestrating': [241], 'CsA': [247, 262], 'eliminated': [248], 'accompanying': [253], 'pulse.': [258], 'shared': [264], 'Ub': [266, 274], 'concentration': [272], 'exceeded': [276], '20': [277], 'μ': [278], 'proved': [282], 'toxic.': [283], 'results': [285], 'thus': [286], 'suggest': [287], 'are': [291], 'different': [292], 'from': [293, 296], 'derived': [295], 'variety': [298], 'other': [300], 'sources.': [301], 'major': [303], 'difference': [304], 'fraction': [308], 'mitochondria,': [312], 'studied': [313], 'presently,': [314], 'depolarized': [315], 'showed': [317], 'signs': [318], 'MPT.': [321], 'This': [322], 'fraction,': [323], 'remaining': [327], 'ones,': [328], 'contributed': [329], 'chemically': [332], 'electron': [334], 'microscopically': [335], 'verified': [336], 'swelling.': [338]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2052943010', 'counts_by_year': [{'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T00:59:36.425477', 'created_date': '2016-06-24'}