Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2052912430', 'doi': 'https://doi.org/10.18388/abp.2014_1871', 'title': 'Influenza viruses resistant to neuraminidase inhibitors.', 'display_name': 'Influenza viruses resistant to neuraminidase inhibitors.', 'publication_year': 2014, 'publication_date': '2014-09-08', 'ids': {'openalex': 'https://openalex.org/W2052912430', 'doi': 'https://doi.org/10.18388/abp.2014_1871', 'mag': '2052912430', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25195142'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18388/abp.2014_1871', 'pdf_url': 'https://ojs.ptbioch.edu.pl/index.php/abp/article/download/1871/504', 'source': {'id': 'https://openalex.org/S166203837', 'display_name': 'Acta Biochimica Polonica', 'issn_l': '0001-527X', 'issn': ['0001-527X', '1734-154X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800658', 'host_organization_name': 'Polish Biochemical Society', 'host_organization_lineage': ['https://openalex.org/P4320800658'], 'host_organization_lineage_names': ['Polish Biochemical Society'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://ojs.ptbioch.edu.pl/index.php/abp/article/download/1871/504', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043941690', 'display_name': 'Aneta Nitsch–Osuch', 'orcid': 'https://orcid.org/0000-0002-2622-7348'}, 'institutions': [{'id': 'https://openalex.org/I268303160', 'display_name': 'Medical University of Warsaw', 'ror': 'https://ror.org/04p2y4s44', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I268303160']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Aneta Nitsch-Osuch', 'raw_affiliation_strings': ['Department of Family Medicine, Warsaw Medical University, Warsaw, Poland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Family Medicine, Warsaw Medical University, Warsaw, Poland.', 'institution_ids': ['https://openalex.org/I268303160']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018782696', 'display_name': 'Lidia B. Brydak', 'orcid': 'https://orcid.org/0000-0003-0553-627X'}, 'institutions': [{'id': 'https://openalex.org/I4210101740', 'display_name': 'National Institute of Public Health', 'ror': 'https://ror.org/015qjap30', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101740']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Lidia Bernadeta Brydak', 'raw_affiliation_strings': ['Department of Influenza Research, National Influenza Center, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Influenza Research, National Influenza Center, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.', 'institution_ids': ['https://openalex.org/I4210101740']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 8000, 'currency': 'PLN', 'value_usd': 2588, 'provenance': 'doaj'}, 'apc_paid': {'value': 8000, 'currency': 'PLN', 'value_usd': 2588, 'provenance': 'doaj'}, 'fwci': 3.813, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.916753, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '61', 'issue': '3', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11243', 'display_name': 'Respiratory viral infections research', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10976', 'display_name': 'Viral gastroenteritis research and epidemiology', 'score': 0.9616, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/oseltamivir', 'display_name': 'Oseltamivir', 'score': 0.9720727}, {'id': 'https://openalex.org/keywords/zanamivir', 'display_name': 'Zanamivir', 'score': 0.9403895}, {'id': 'https://openalex.org/keywords/neuraminidase-inhibitor', 'display_name': 'Neuraminidase inhibitor', 'score': 0.7695271}, {'id': 'https://openalex.org/keywords/pandemic', 'display_name': 'Pandemic', 'score': 0.5262227}, {'id': 'https://openalex.org/keywords/cross-resistance', 'display_name': 'Cross-resistance', 'score': 0.41021997}], 'concepts': [{'id': 'https://openalex.org/C2780374985', 'wikidata': 'https://www.wikidata.org/wiki/Q211509', 'display_name': 'Oseltamivir', 'level': 5, 'score': 0.9720727}, {'id': 'https://openalex.org/C2781442963', 'wikidata': 'https://www.wikidata.org/wiki/Q146075', 'display_name': 'Zanamivir', 'level': 5, 'score': 0.9403895}, {'id': 'https://openalex.org/C134164806', 'wikidata': 'https://www.wikidata.org/wiki/Q409485', 'display_name': 'Neuraminidase', 'level': 3, 'score': 0.9356936}, {'id': 'https://openalex.org/C2777538117', 'wikidata': 'https://www.wikidata.org/wiki/Q425196', 'display_name': 'Neuraminidase inhibitor', 'level': 5, 'score': 0.7695271}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.70360434}, {'id': 'https://openalex.org/C519248777', 'wikidata': 'https://www.wikidata.org/wiki/Q160122', 'display_name': 'Influenza A virus subtype H5N1', 'level': 3, 'score': 0.66528505}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.5288989}, {'id': 'https://openalex.org/C89623803', 'wikidata': 'https://www.wikidata.org/wiki/Q12184', 'display_name': 'Pandemic', 'level': 5, 'score': 0.5262227}, {'id': 'https://openalex.org/C2777546802', 'wikidata': 'https://www.wikidata.org/wiki/Q834390', 'display_name': 'Influenza A virus', 'level': 3, 'score': 0.49027446}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.47127908}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4429071}, {'id': 'https://openalex.org/C2778080818', 'wikidata': 'https://www.wikidata.org/wiki/Q1788422', 'display_name': 'Cross-resistance', 'level': 2, 'score': 0.41021997}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.39526412}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36185527}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.16869771}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.078582436}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.06700671}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.046967298}], 'mesh': [{'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D053124', 'descriptor_name': 'Influenza A Virus, H5N1 Subtype', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007251', 'descriptor_name': 'Influenza, Human', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009439', 'descriptor_name': 'Neuraminidase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053124', 'descriptor_name': 'Influenza A Virus, H5N1 Subtype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007251', 'descriptor_name': 'Influenza, Human', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D007251', 'descriptor_name': 'Influenza, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007251', 'descriptor_name': 'Influenza, Human', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D009439', 'descriptor_name': 'Neuraminidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053139', 'descriptor_name': 'Oseltamivir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053139', 'descriptor_name': 'Oseltamivir', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D053243', 'descriptor_name': 'Zanamivir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053243', 'descriptor_name': 'Zanamivir', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18388/abp.2014_1871', 'pdf_url': 'https://ojs.ptbioch.edu.pl/index.php/abp/article/download/1871/504', 'source': {'id': 'https://openalex.org/S166203837', 'display_name': 'Acta Biochimica Polonica', 'issn_l': '0001-527X', 'issn': ['0001-527X', '1734-154X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800658', 'host_organization_name': 'Polish Biochemical Society', 'host_organization_lineage': ['https://openalex.org/P4320800658'], 'host_organization_lineage_names': ['Polish Biochemical Society'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25195142', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18388/abp.2014_1871', 'pdf_url': 'https://ojs.ptbioch.edu.pl/index.php/abp/article/download/1871/504', 'source': {'id': 'https://openalex.org/S166203837', 'display_name': 'Acta Biochimica Polonica', 'issn_l': '0001-527X', 'issn': ['0001-527X', '1734-154X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800658', 'host_organization_name': 'Polish Biochemical Society', 'host_organization_lineage': ['https://openalex.org/P4320800658'], 'host_organization_lineage_names': ['Polish Biochemical Society'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1983513198', 'https://openalex.org/W1991335064', 'https://openalex.org/W2004554957', 'https://openalex.org/W2008617110', 'https://openalex.org/W2016256501', 'https://openalex.org/W2043990443', 'https://openalex.org/W2046339130', 'https://openalex.org/W2046938649', 'https://openalex.org/W2063205025', 'https://openalex.org/W2079280754', 'https://openalex.org/W2088402140', 'https://openalex.org/W2104397822', 'https://openalex.org/W2108157089', 'https://openalex.org/W2110421864', 'https://openalex.org/W2111155300', 'https://openalex.org/W2114582344', 'https://openalex.org/W2117004115', 'https://openalex.org/W2117512155', 'https://openalex.org/W2125404577', 'https://openalex.org/W2126078732', 'https://openalex.org/W2130441728', 'https://openalex.org/W2149087734', 'https://openalex.org/W2150047295', 'https://openalex.org/W2162384187', 'https://openalex.org/W2164343098', 'https://openalex.org/W2187359559', 'https://openalex.org/W2409649694', 'https://openalex.org/W2412876393', 'https://openalex.org/W2736483456'], 'related_works': ['https://openalex.org/W4385693043', 'https://openalex.org/W3217119701', 'https://openalex.org/W2350804570', 'https://openalex.org/W2165202620', 'https://openalex.org/W2159382969', 'https://openalex.org/W2132657130', 'https://openalex.org/W2123034187', 'https://openalex.org/W2079879957', 'https://openalex.org/W2042995083', 'https://openalex.org/W1966462939'], 'abstract_inverted_index': {'Neuraminidase': [0], 'inhibitors': [1], '(NAIs)': [2], 'are': [3, 46, 124], 'antiviral': [4, 50, 197], 'drugs': [5], 'for': [6, 211], 'treatment': [7, 188, 212], 'and': [8, 65, 143, 161, 170, 213, 218], 'prophylaxis': [9, 214], 'of': [10, 16, 31, 38, 49, 88, 113, 120, 132, 141, 145, 148, 196, 202, 215], 'influenza.': [11, 220], 'By': [12], 'blocking': [13], 'the': [14, 17, 36, 43, 54, 133, 192, 208], 'activity': [15], 'enzyme': [18], 'neuraminidase,': [19], 'NAIs': [20, 32, 76, 163, 203], 'prevent': [21], 'new': [22], 'viral': [23], 'particles': [24], 'from': [25, 181], 'being': [26], 'released.': [27], 'The': [28, 129, 185, 199], 'increasing': [29, 86], 'use': [30, 201], 'brings': [33], 'into': [34], 'focus': [35], 'risk': [37], 'drug': [39], 'resistance': [40, 51, 57, 74, 134, 158, 164], 'arising': [41], 'to': [42, 53, 75, 93, 110, 127, 135, 187, 206], 'class.': [44], 'There': [45], 'three': [47], 'levels': [48], 'according': [52], 'way': [55], 'that': [56], 'can': [58], 'be': [59], 'detected': [60], 'or': [61], 'inferred:': [62], 'genotypic,': [63], 'phenotypic': [64], 'clinical': [66], 'resistance.': [67], 'For': [68], 'many': [69], 'years': [70], 'seasonal': [71, 90], 'influenza': [72, 91, 114, 121, 149, 166], 'viruses': [73, 167, 177], 'was': [77], 'low': [78], '(0.33%).': [79], 'Recently,': [80], 'there': [81, 103], 'has': [82, 152], 'been': [83, 153], 'described': [84], 'an': [85], 'number': [87], 'resistant': [89, 109, 126, 176], 'strains': [92, 112], 'oseltamivir': [94, 111, 136, 160], '(2%': [95], 'in': [96, 99, 116, 139, 165], 'adults,': [97], '5-18%': [98], 'children).': [100], 'In': [101], '2007': [102], 'were': [104, 137], 'published': [105], 'data': [106], 'describing': [107], '14%': [108], 'A/H1N1/': [115], 'Europe.': [117], 'Approximately': [118], '0.5-1.0%': [119], 'A/H1N1/pdm09': [122], 'isolates': [123, 147], 'currently': [125], 'oseltamivir.': [128], 'established': [130], 'markers': [131], 'found': [138], '2.4%': [140], 'human': [142], '0.8%': [144], 'avian': [146, 217], 'A/H5N1/.': [150], 'It': [151], 'not': [154], 'observed': [155], 'a': [156], 'cross': [157], 'among': [159], 'zanamivir.': [162], 'is': [168, 204], 'relative': [169], 'despite': [171], 'its': [172], 'presence': [173], 'patients': [174], 'with': [175, 189], 'may': [178], 'still': [179], 'benefit': [180], 'receiving': [182], 'these': [183], 'antivirals.': [184], 'response': [186], 'antivirals': [190], 'remains': [191], 'most': [193], 'important': [194], 'proof': [195], 'effectiveness.': [198], 'rational': [200], 'essential': [205], 'preserve': [207], 'best': [209], 'choice': [210], 'seasonal,': [216], 'pandemic': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2052912430', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2025-01-02T12:04:05.171766', 'created_date': '2016-06-24'}