Identification of the Anti-angiogenic Site within Vascular Basement Membrane-derived Tumstatin

Name: Work Video:
Duration: 3 min 30 s
Yohei Maeshima; Mark Manfredi; Corinne Reimer; Kathryn A. Holthaus; Helmut Hopfer; Babi R. Chandamuri; Surender Kharbanda; Raghu Kalluri
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'https://openalex.org/W1983067812'], 'abstract_inverted_index': {'Components': [0, 227], 'of': [1, 15, 18, 35, 72, 87, 102, 139, 185, 197, 215, 225, 228, 242, 245, 262, 299, 314, 329, 366, 412, 424, 442, 452, 494, 539, 549, 588, 599, 790, 838, 852, 944, 949, 1019, 1171, 1182, 1264, 1267, 1279, 1445, 1547, 1648, 1658, 1678, 1695, 1710, 1723, 1734, 1827, 1884, 1955, 2069, 2092, 2351, 2356, 2460, 2843, 2961, 3035, 3141, 3146, 3317, 3333, 3426, 3449, 3457, 3469, 3546, 3556, 3566, 3589, 3600, 3621, 3709, 3747, 3821, 3834, 3837, 3850, 3855, 3864, 3869, 3924, 3955, 4084, 4094, 4174, 4249, 4386, 4424, 4442, 4493], 'vascular': [2, 229, 1433, 3856], 'basement': [3, 230, 845, 950, 1013, 1192], 'membrane': [4, 231, 846, 1193], 'are': [5, 232, 566, 590, 785, 992, 1017, 3828, 4417], 'involved': [6, 233], 'in': [7, 54, 107, 114, 123, 127, 142, 147, 152, 234, 281, 334, 341, 350, 354, 369, 374, 379, 543, 864, 1069, 1179, 1281, 1440, 1443, 1502, 1609, 1636, 1720, 1830, 1897, 1973, 2030, 2099, 2336, 2358, 2366, 2452, 2467, 2592, 2644, 2755, 2759, 2963, 2986, 3004, 3019, 3032, 3119, 3246, 3275, 3344, 3423, 3581, 3700, 3741, 3829, 3900, 3907, 4117, 4136, 4310, 4437, 4462, 4471], 'regulating': [8, 235, 865], 'angiogenesis.': [9, 198, 236, 425, 1727], 'Recently,': [10, 237, 1343], 'tumstatin': [11, 36, 238, 263, 1497, 1548, 1735, 1885, 1978, 2667], '(the': [12, 239, 4208], 'NC1': [13, 240, 1169, 1262], 'domain': [14, 207, 241, 434, 1037, 1170, 1263, 1546, 1714, 1904, 4492], 'α3': [16, 243, 1265], 'chain': [17, 244, 1266, 1740], 'type': [19, 246, 1172, 1183, 1268], 'IV': [20, 247, 940, 1062, 1173, 1184, 1269], 'collagen)': [21, 248], 'was': [22, 37, 104, 249, 264, 331, 1590, 1736, 1819, 1840, 1971, 1979, 2028, 2064, 2086, 2097, 2136, 2234, 2286, 2298, 2375, 2443, 2472, 2487, 2504, 2550, 2557, 2620, 2654, 2733, 2768, 2780, 2838, 2858, 2940, 3043, 3083, 3133, 3197, 3296, 3323, 3336, 3342, 3362, 3371, 3451, 3471, 3485, 3604, 3624, 3656, 3662, 3694, 3715, 3718, 3731, 3755, 3845, 3882, 3947, 3992, 4103, 4218, 4244, 4277, 4307, 4333, 4341, 4362, 4404, 4431, 4446, 4451, 4477, 4500], 'identified': [23, 250, 1345, 1495, 1902], 'as': [24, 193, 251, 420, 787, 833, 969, 1549, 1592, 1627, 1671, 1715, 1746, 1842, 1888, 1987, 2142, 2214, 2240, 2389, 2506, 2782, 2830, 2878, 3156, 3199, 3298, 3373, 3487, 3664, 3757, 4163, 4335, 4419, 4453, 4503], 'possessing': [25, 252], 'anti-angiogenic': [26, 33, 100, 253, 260, 327, 868, 1353, 1513, 1545, 1693, 1903, 4491], 'activity.': [27, 254], 'In': [28, 172, 255, 399, 1490, 1537, 1684, 2132, 2917, 3750, 4125, 4205, 4231], 'the': [29, 32, 40, 47, 177, 183, 223, 256, 259, 267, 274, 404, 410, 450, 492, 537, 547, 796, 945, 1012, 1022, 1027, 1033, 1076, 1180, 1277, 1538, 1541, 1631, 1637, 1686, 1692, 1708, 1721, 1743, 1892, 1900, 1953, 2067, 2382, 2623, 2652, 2698, 2856, 2861, 2873, 2929, 2959, 2997, 3036, 3125, 3306, 3326, 3424, 3447, 3467, 3480, 3601, 3607, 3619, 3815, 3832, 3835, 3893, 3922, 3979, 3990, 3995, 4092, 4186, 4224, 4234, 4345, 4368, 4378, 4383, 4465, 4486], 'present': [30, 257, 1539, 1638, 1687, 2559], 'study,': [31, 258, 1540], 'activity': [34, 48, 261, 275, 1354, 1514, 1694, 3196, 4276], 'localized': [38, 265], 'to': [39, 266, 545, 594, 859, 1002, 1009, 1066, 1186, 1275, 1315, 1317, 1499, 1645, 1663, 1899, 1951, 2077, 2084, 2088, 2552, 2600, 2629, 2697, 2740, 2958, 3085, 3637, 3650, 3723, 4072, 4074, 4222, 4290, 4433, 4479, 4484], 'putative': [41, 268, 1542, 4487], '54–132-amino': [42, 269, 1543], 'acid': [43, 270, 1544], 'Tum-5': [44, 60, 82, 103, 132, 162, 271, 287, 309, 330, 359, 389, 1603, 1616, 1642, 1652, 1668, 1696, 2027, 2070, 2073, 2093, 2135, 2233, 2664, 2767, 2833, 2935, 2991, 3137, 3281, 3427, 3547, 3693, 3865, 4450, 4476], 'domain,': [45, 272, 1026, 1031], 'and': [46, 64, 69, 92, 117, 218, 273, 291, 296, 319, 344, 445, 506, 536, 602, 801, 836, 856, 867, 966, 1032, 1073, 1189, 1311, 1320, 1435, 1442, 1506, 1599, 1606, 1833, 2140, 2194, 2212, 2238, 2270, 2290, 2320, 2353, 2387, 2450, 2494, 2704, 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[59, 286, 1593, 1828, 2495, 2990, 3877], 'produced': [61, 288, 591, 4452], 'inEscherichia': [62, 289], 'coli': [63, 290, 1598, 1832, 4497], 'Pichia': [65, 292], 'Pastorisspecifically': [66, 293], 'inhibited': [67, 84, 137, 294, 311, 364], 'proliferation': [68, 295, 1072, 1278, 2625], 'caused': [70, 297], 'apoptosis': [71, 298, 3087], 'endothelial': [73, 88, 95, 300, 315, 322, 459, 463, 802, 842, 1070, 1446, 1625, 1664, 1682, 2305, 2311, 2602, 3367, 3857], 'cells': [74, 89, 301, 316, 464, 803, 840, 1434, 1626, 1986, 2306, 2312, 2462, 2609, 2638, 2682, 2750, 2822, 2862, 2923, 2943, 2962, 2971, 2998, 3010, 3061, 3109, 3151, 3240, 3265, 3310, 3318, 3354, 3432, 3623, 3977], 'with': [75, 144, 302, 371, 1011, 1431, 1654, 1961, 2035, 2104, 2275, 2296, 2343, 2455, 2478, 2489, 2633, 2656, 2661, 2688, 2701, 2746, 2840, 2919, 2928, 2984, 3055, 3077, 3136, 3251, 3268, 3435, 3543, 3563, 3585, 3626, 3720, 3733, 3831, 3847, 3972, 4264, 4295, 4325, 4358, 4426, 4457], 'no': [76, 303], 'significant': 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340, 487, 2619, 2626, 2738, 3361, 3370, 3484, 3754], 'C57BL/6': [115, 342], 'mice': [116, 343, 3799, 3889, 4187], 'human': [118, 161, 170, 345, 388, 397, 460, 1983, 2308, 2314, 2844, 3429, 3638, 3651, 4101], 'prostate': [119, 346, 2315], 'cancer': [120, 347], '(PC-3)': [121, 348, 3355], 'xenografts': [122, 349, 4252], 'nude': [124, 351, 3961], 'mice.': [125, 352, 4086], 'vivo': [128, 153, 355, 380, 1610, 3751], 'results': [129, 356, 1705], 'demonstrate': [130, 203, 357, 430], 'that': [131, 181, 204, 358, 408, 431, 585, 794, 997, 1346, 1496, 1641, 1667, 1691, 2072, 2556, 2596, 4381], 'at': [133, 158, 164, 360, 385, 391, 2381, 2679, 2852, 2966, 3013, 3046, 3349, 3443, 3553, 3614, 3745, 4108, 4301, 4364, 4370, 4377], '1': [134, 361, 455, 2932, 3050], 'mg/kg': [135, 362, 4113], 'significantly': [136, 363], 'growth': [138, 365, 505, 603, 1608, 2604, 2945, 3271, 3858, 4226], 'PC-3': [140, 367, 3976, 4250], 'tumors': [141, 368, 3983, 4069, 4194], 'association': [143, 370], 'decrease': [146, 373], 'CD31': [148, 375, 4203, 4305], 'positive': [149, 376, 3300], 'vasculature.': [150, 377], 'These': [151, 378, 564, 990, 1015, 1704, 2208, 2331], 'studies': [154, 175, 381, 402, 578, 3809], 'show': [156, 383], 'that,': [157, 384], 'molar': [159, 386, 3707], 'equivalents,': [160, 387], 'is': [163, 211, 390, 438, 501, 857, 942, 967, 1064, 1196, 1428, 1509, 1656, 1697, 2597], 'least': [165, 392], '10-fold': [166, 393], 'more': [167, 394], 'active': [168, 395], 'than': [169, 396, 1967, 2588], 'endostatin.': [171, 398, 3430], 'addition,': [173, 400, 1685, 4126], 'these': [174, 201, 401, 428, 1974], 'for': [176, 222, 403, 449, 503, 799, 1006, 1198, 1511, 1630, 2066, 2138, 2676, 2685, 2772, 2849, 2865, 2931, 2950, 3016, 3049, 3081, 3260, 3286, 3338, 3440, 3479, 3571, 3594, 3611, 3949, 4114, 4228, 4282, 4298, 4318], 'first': [178, 405, 4365], 'time': [179, 406, 2681, 2968], 'suggest': [180, 407, 1640], 'through': [182, 409, 1620], 'action': [184, 411], 'endogenous': [186, 413, 586], 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3677, 3780, 4022, 4053], 'Nat.': [510, 554], 'Med.': [511, 555], '1995;': [512, 556, 982], '1:': [513, 557], '27-31Crossref': [514, 558], 'PubMed': [515, 527, 559, 631, 665, 701, 778, 814, 918, 934, 961, 985, 1056, 1110, 1163, 1210, 1224, 1250, 1306, 1386, 1421, 1459, 1485, 1532, 1585, 1780, 1812, 1876, 1939, 2021, 2160, 2227, 2262, 2409, 2540, 2577, 2816, 2912, 3103, 3190, 3233, 3407, 3507, 3534, 3683, 3791, 4030, 4063], 'Scopus': [516, 528, 560, 632, 666, 702, 779, 815, 919, 935, 962, 986, 1057, 1111, 1164, 1211, 1225, 1251, 1307, 1387, 1422, 1460, 1486, 1533, 1586, 1781, 1877, 1940, 2022, 2228, 2263, 2410, 2541, 2578, 2817, 2913, 3104, 3191, 3234, 3408, 3508, 3535, 3684, 3792, 4031, 4064], '(7153)': [517, 561], 'Google': [518, 530, 562, 634, 668, 704, 745, 781, 817, 909, 921, 937, 964, 988, 1059, 1113, 1154, 1166, 1213, 1227, 1253, 1309, 1341, 1389, 1424, 1462, 1488, 1535, 1588, 1783, 1813, 1879, 1942, 2024, 2061, 2130, 2161, 2188, 2230, 2265, 2412, 2440, 2543, 2580, 2819, 2915, 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'orchestrate': [595], 'systematic': [597], 'regulation': [598, 1677], 'uptake': [601], "(3O'Reilly": [604, 4003], 'M.S.': [605, 637, 4004, 4035], 'Holmgren': [606, 4005], 'L.': [607, 4006], 'Shing': [608, 640, 4007, 4038], 'Y.': [609, 619, 641, 683, 713, 748, 762, 877, 1092, 1122, 1356, 1370, 1400, 1402, 1516, 1555, 1569, 1750, 1764, 1846, 1860, 1909, 1923, 1991, 2005, 2393, 2522, 2786, 2800, 2894, 3172, 3203, 3217, 3377, 3391, 3491, 3761, 3775, 4008, 4018, 4039], 'Chen': [610, 4009], 'C.': [611, 4010], 'Rosenthal': [612, 4011], 'R.A.': [613, 1452, 1471, 4012], 'Moses': [614, 4013], 'M.': [615, 727, 729, 731, 805, 891, 893, 895, 1136, 1138, 1140, 1469, 1796, 2041, 2049, 2053, 2110, 2118, 2122, 2172, 3090, 3523, 4014], 'Lane': [616, 646, 4015, 4044], 'W.S.': [617, 647, 4016, 4045], 'Cao': [618, 4017], 'Sage': [620, 4019], 'E.H.': [621, 4020], 'Folkman': [622, 654, 4021, 4052], 'Cell.': [624, 656, 956, 1219, 1478, 4023, 4054], '1994;': [625, 1456, 1479, 4024], '79:': [626, 1480, 4025], '315-328Abstract': [627, 4026], 'Full': [628, 660, 662, 696, 698, 773, 775, 1105, 1107, 1301, 1303, 1381, 1383, 1416, 1418, 1482, 1527, 1529, 1580, 1582, 1775, 1777, 1809, 1871, 1873, 1934, 1936, 2016, 2018, 2157, 2185, 2257, 2259, 2404, 2406, 2535, 2537, 2811, 2813, 2907, 2909, 3185, 3187, 3228, 3230, 3402, 3404, 3502, 3504, 3786, 3788, 4027, 4058, 4060], 'Text': [629, 661, 663, 697, 699, 774, 776, 1106, 1108, 1302, 1304, 1382, 1384, 1417, 1419, 1483, 1528, 1530, 1581, 1583, 1776, 1778, 1810, 1872, 1874, 1935, 1937, 2017, 2019, 2158, 2186, 2258, 2260, 2405, 2407, 2536, 2538, 2812, 2814, 2908, 2910, 3186, 3188, 3229, 3231, 3403, 3405, 3503, 3505, 3787, 3789, 4028, 4059, 4061], 'PDF': [630, 664, 700, 777, 1109, 1305, 1385, 1420, 1484, 1531, 1584, 1779, 1811, 1875, 1938, 2020, 2159, 2187, 2261, 2408, 2539, 2815, 2911, 3189, 3232, 3406, 3506, 3790, 4029, 4062], '(3138)': [633, 4032], "4O'Reilly": [636], 'Boehm': [638, 4036], 'T.': [639, 1473, 1794, 4037], 'Fukai': [642, 4040], 'N.': [643, 1286, 4041], 'Vasios': [644, 4042], 'G.': [645, 711, 875, 1120, 1331, 1475, 2567, 2571, 4043], 'Flynn': [648, 4046], 'E.': [649, 1392, 1831, 2222, 4047, 4463, 4496], 'Birkhead': [650, 4048], 'J.R.': [651, 4049], 'Olsen': [652, 4050], 'B.R.': [653, 4051], '1997;': [657, 915, 1160, 1207, 1298, 2574, 3531, 3680, 4055], '88:': [658, 4056], '277-285Abstract': [659, 4057], '(4199)': [667, 4065], '5Kamphaus': [670], 'G.D.': [671, 1080, 2510, 2882, 3160], 'Colorado': [672, 749, 1081, 1357, 1517, 1556, 1751, 1847, 1910, 1992, 2394, 2511, 2787, 2883, 3161, 3204, 3378, 3492, 3762], 'P.C.': [673, 707, 750, 871, 1082, 1116, 1358, 1409, 1450, 1465, 1518, 1557, 1752, 1848, 1911, 1993, 2395, 2512, 2788, 2884, 3162, 3205, 3379, 3493, 3763], 'Panka': [674, 1083, 2513, 2885, 3163], 'D.J.': [675, 976, 1084, 2514, 2886, 3164], 'Hopfer': [676, 714, 759, 878, 1085, 1123, 1367, 1566, 1761, 1857, 1920, 2002, 2515, 2797, 2887, 3165, 3214, 3388, 3772], 'H.': [677, 715, 760, 879, 1042, 1047, 1086, 1124, 1368, 1567, 1762, 1858, 1921, 2003, 2425, 2433, 2516, 2798, 2888, 3166, 3215, 3389, 3773], 'Ramchandran': [678, 1087, 2042, 2111, 2517, 2889, 3167], 'R.': [679, 689, 719, 739, 766, 883, 903, 924, 953, 1040, 1088, 1098, 1128, 1148, 1216, 1374, 1520, 1573, 1768, 1788, 1864, 1927, 2009, 2043, 2045, 2112, 2114, 2164, 2220, 2244, 2397, 2518, 2528, 2563, 2804, 2890, 2900, 3168, 3178, 3221, 3395, 3495, 3668, 3779], 'Torre': [680, 708, 751, 872, 1089, 1117, 1359, 1558, 1753, 1849, 1912, 1994, 2519, 2789, 2891, 3169, 3206, 3380, 3764], 'A.': [681, 709, 752, 873, 1090, 1118, 1329, 1360, 1394, 1396, 1559, 1754, 1850, 1913, 1995, 2421, 2520, 2790, 2892, 3170, 3207, 3381, 3530, 3765], 'Maeshima': [682, 712, 876, 1091, 1121, 2521, 2893, 3171], 'Mier': [684, 1093, 2523, 2895, 3173], 'J.W.': [685, 1094, 2524, 2896, 3174], 'Sukhatme': [686, 736, 900, 925, 1095, 1145, 2054, 2123, 2525, 2897, 3175], 'V.P.': [687, 737, 901, 926, 1096, 1146, 2055, 2124, 2526, 2898, 3176], 'Kalluri': [688, 738, 765, 902, 1097, 1147, 1373, 1519, 1572, 1767, 1787, 1863, 1926, 2008, 2396, 2527, 2803, 2899, 3177, 3220, 3394, 3494, 3778], 'Biol.': [691, 768, 810, 957, 1100, 1220, 1246, 1296, 1376, 1411, 1522, 1575, 1770, 1804, 1866, 1929, 2011, 2152, 2180, 2252, 2399, 2530, 2806, 2902, 3180, 3223, 3397, 3497, 3781], 'Chem.': [692, 769, 1101, 1297, 1377, 1412, 1523, 1576, 1771, 1805, 1867, 1930, 2012, 2153, 2181, 2253, 2400, 2531, 2807, 2903, 3181, 3224, 3398, 3498, 3782], '2000;': [693, 742, 770, 906, 931, 1102, 1151, 1378, 1413, 1524, 1577, 1772, 1868, 1931, 2013, 2401, 2532, 2808, 2904, 3182, 3225, 3399, 3499, 3783], '275:': [694, 771, 1103, 1379, 1414, 1525, 1578, 1773, 1869, 1932, 2014, 2402, 2533, 2809, 2905, 3183, 3226, 3400, 3500, 3784], '1209-1215Abstract': [695, 1104, 2534, 2906, 3184], '(402)': [703, 1112, 2542, 2914, 3192], '6Colorado': [706, 1115], 'Kamphaus': [710, 874, 1119], 'Takahashi': [716, 880, 1125], 'K.': [717, 881, 1049, 1126, 2427], 'Volk': [718, 882, 1127, 2044, 2113], 'Zamborsky': [720, 884, 1129], 'E.D.': [721, 885, 1130], 'Herman': [722, 886, 1131], 'S.': [723, 887, 1132, 1288, 1327, 1792, 2148, 2166, 2561, 2565, 3529], 'Ericksen': [724, 757, 888, 1133, 1365, 1564, 1759, 1855, 1918, 2000, 2795, 3212, 3386, 3770], 'M.B.': [725, 889, 1134], 'Dhanabal': [726, 890, 1135], 'Simons': [728, 892, 1137, 2052, 2121], 'Post': [730, 894, 1139], 'Kufe': [732, 896, 1141], 'D.W.': [733, 897, 1142], 'Weichselbaum': [734, 898, 1143], 'R.R.': [735, 899, 1144], 'Cancer': [740, 904, 1149, 1336, 2056, 2125], 'Res.': [741, 905, 1150, 1337, 2057, 2126, 2436], '60:': [743, 907, 1152], '2520-2526PubMed': [744, 908, 1153], '7Maeshima': [747], 'Holthaus': [753, 1361, 1560, 1755, 1851, 1914, 1996, 2791, 3208, 3382, 3766], 'K.A.': [754, 1362, 1561, 1756, 1852, 1915, 1997, 2792, 3209, 3383, 3767], 'Grunkemeyer': [755, 1363, 1562, 1757, 1853, 1916, 1998, 2793, 3210, 3384, 3768], 'J.A.': [756, 912, 1157, 1204, 1364, 1563, 1758, 1854, 1917, 1999, 2794, 3211, 3385, 3769], 'M.D.': [758, 1366, 1565, 1760, 1856, 1919, 2001, 2796, 3213, 3387, 3771], 'Xiao': [761, 1369, 1568, 1763, 1859, 1922, 2004, 2799, 3216, 3390, 3774], 'Stillman': [763, 1371, 1570, 1765, 1861, 1924, 2006, 2046, 2115, 2801, 3218, 3392, 3776], 'I.E.': [764, 1372, 1571, 1766, 1862, 1925, 2007, 2047, 2116, 2802, 3219, 3393, 3777], '21340-21348Abstract': [772, 1380, 1579, 1774, 1870, 1933, 2015, 2810, 3227, 3401, 3785], '(327)': [780, 1388, 1587, 1782, 1878, 1941, 2023, 2818, 3235, 3409, 3793], 'Basement': [783, 819], 'membranes': [784, 820, 951], 'organized': [786], 'thin': [788], 'layers': [789], 'specialized': [791], 'extracellular': [792], 'matrix': [793], 'provide': [795, 823, 1003], 'supporting': [797], 'scaffold': [798, 1005], 'epithelial': [800], '(8Paulsson': [804], 'Crit.': [806], 'Rev.': [807, 980], 'Biochem.': [808, 981, 1052, 2573], 'Mol.': [809], '1992;': [811], '27:': [812], '93-127Crossref': [813], '(461)': [816], 'not': [821, 1698, 2598, 2606, 3875], 'only': [822], 'mechanical': [825], 'support': [826], 'but': [827], 'influence': [829], 'cellular': [830], 'behavior': [831, 1074], 'such': [832], 'differentiation,': [834], 'proliferation,': [835], 'migration': [837], 'various': [839], 'including': [841], 'Vascular': [844], 'constitutes': [847], 'insoluble': [849], 'structural': [850], 'wall': [851], 'newly': [853], 'formed': [854], 'capillaries': [855], 'speculated': [858], 'play': [860], 'important': [862, 1068, 1197], 'role': [863, 1178, 1439], 'pro-': [866], '(6Colorado': [870], '9Madri': [911, 1156], 'Transpl.': [913, 1158, 1205], 'Immunol.': [914, 1159, 1206], '5:': [916, 1161, 1208], '179-183Crossref': [917, 1162, 1209], '(58)': [920, 1165, 1212], '10Kalluri': [923], 'Curr.': [927, 954, 1217], 'Opin.': [928, 955, 1218], 'Nephrol.': [929], 'Hypertens.': [930], '9:': [932], '413-418Crossref': [933], '(81)': [936], 'Type': [939, 1061, 2328, 2447], 'collagen': [941, 1063, 1174, 1185, 1270], 'one': [943, 4137], 'major': [946], 'macromolecular': [947], 'constituents': [948], '(11Timpl': [952], '1996;': [958, 1221, 2254], '8:': [959, 1222], '618-624Crossref': [960, 1223], '(548)': [963, 1226], 'Scholar)': [965, 1310, 1589], 'expressed': [968, 1591, 1887, 1980, 2029, 2098, 4418, 4478, 4498], 'six': [970], 'distinct': [971], 'α-chains,': [972], 'namely,': [973], 'α1–α6': [974], '(12Prockop': [975], 'Kivirikko': [977], 'K.I.': [978], 'Annu.': [979], '64:': [983], '403-434Crossref': [984], '(1355)': [987], 'α-chains': [991, 1016], 'assembled': [993], 'into': [994, 1821, 2979, 3978, 4082], 'triple': [995, 1029], 'helices': [996], 'further': [998], 'form': [999, 1187], 'network': [1001], 'other': [1007], 'macromolecules': [1008], 'interact': [1010], 'membrane.': [1014], 'composed': [1018], 'three': [1020, 3364, 4375], 'domains,': [1021], 'N-terminal': [1023, 1893], '7': [1024], 'S': [1025, 2964], 'middle': [1028], 'helical': [1030], 'C-terminal': [1034, 2078, 4459], 'globular': [1035], '(NC1)1': [1038], '(13Timpl': [1039], 'Wiedemann': [1041], 'van': [1043], 'Delden': [1044], 'V.': [1045], 'Furthmayr': [1046], 'Kuhn': [1048], 'Eur.': [1050], '1981;': [1053], '120:': [1054], '203-211Crossref': [1055], '(643)': [1058], 'thought': [1065], 'be': [1067, 2075], 'during': [1075], 'process': [1078], '(5Kamphaus': [1079, 2509, 2881, 3159], 'plays': [1175, 1436], 'crucial': [1177], 'assembly': [1181], 'trimers': [1188], 'thus': [1190], 'influences': [1191], 'organization,': [1194], 'which': [1195, 1890, 2680], 'vessel': [1201], '(9Madri': [1203], '11Timpl': [1215], 'Scholar,14Tsilibary': [1228], 'E.C.': [1229], 'Reger': [1230], 'L.A.': [1231], 'Vogel': [1232], 'A.M.': [1233, 1467, 2146], 'Koliakos': [1234], 'G.G.': [1235], 'Anderson': [1236], 'S.S.': [1237], 'Charonis': [1238], 'A.S.': [1239], 'Alegre': [1240], 'J.N.': [1241], 'Furcht': [1242], 'L.T.': [1243], 'Cell': [1245, 2731], '1990;': [1247, 2437], '111:': [1248], '1583-1591Crossref': [1249], '(46)': [1252], 'Synthetic': [1255, 2190], 'peptides': [1256, 2191, 2196, 2209], '(amino': [1257], 'acids': [1258, 1882, 1896, 1948, 4482, 4489], '185–203)': [1259], '(α3(IV)NC1)': [1271], 'been': [1273, 1313], 'inhibit': [1276], 'melanoma': [1280, 2371], 'vitro': [1282], '(15Han': [1283], 'Ohno': [1285], 'Pasco': [1287, 1326], 'Monboisse': [1289, 1332], 'J.C.': [1290, 1333, 1798], 'Borel': [1291], 'J.P.': [1292], 'Kefalides': [1293, 1334], 'N.A.': [1294, 1335], '272:': [1299], '20395-20401Abstract': [1300], '(87)': [1308], 'found': [1314], 'bind': [1316], 'CD47/IAP': [1321], '(16Shahan': [1322], 'T.A.': [1323], 'Ziaie': [1324], 'Z.': [1325], 'Fawzi': [1328], 'Bellon': [1330], '1999;': [1338, 2058, 2127], '59:': [1339, 2059, 2128], '4584-4590PubMed': [1340], 'we': [1344, 1493], 'α3(IV)NC1,': [1347], 'termed': [1348], '“tumstatin,”': [1349], 'possessed': [1350], 'novel': [1352, 1712], '(7Maeshima': [1355, 1554, 1749, 1845, 1908, 1990, 2785, 3202, 3376, 3760], '17Petitclerc': [1391], 'Boutaud': [1393], 'Prestayko': [1395], 'Xu': [1397], 'Sado': [1399], 'Ninomiya': [1401], 'Sarras': [1403], 'Jr.,': [1404], 'M.P.': [1405], 'Hudson': [1406, 1801, 2177, 2247, 3673], 'B.G.': [1407, 1802, 2178, 2248, 3674], 'Brooks': [1408], '8051-8061Abstract': [1415], '(273)': [1423], 'Integrin': [1426], 'potentially': [1429], 'associated': [1430], 'critical': [1438], 'promotion': [1444], 'survival': [1448], '(18Brooks': [1449], 'Clark': [1451], 'Cheresh': [1453, 1476], 'D.A.': [1454, 1477], 'Science.': [1455, 2223], '264:': [1457], '569-571Crossref': [1458], '(2704)': [1461], '19Brooks': [1464], 'Montgomery': [1466], 'Rosenfeld': [1468], 'Reisfeld': [1470], 'Hu': [1472], 'Klier': [1474], '1157-1164Abstract': [1481], '(2161)': [1487], 'this': [1491, 1507, 1711, 2967, 4206], 'regard,': [1492], 'recently': [1494], 'binds': [1498, 1643], 'manner,': [1505], 'binding': [1508, 1662, 3710], 'essential': [1510], 'its': [1512], '(20Maeshima': [1515, 2392, 3490], '23745-23750Abstract': [1526, 2403, 3501], '(232)': [1534, 2411, 3509], 'determined': [1550, 3198, 3625], 'deletion': [1552, 1731], 'mutagenesis': [1553, 2082], 'protein': [1594, 1713, 1829, 1956, 1960, 2847, 3076, 3711, 4456, 4499, 4505], '(Tum-5)': [1595, 4139], 'using': [1596, 1611, 1738, 1835, 1981, 2032, 2101, 2612, 2622, 2710, 2872, 3064, 3453, 3986, 3994, 4129, 4253, 4279, 4411, 4473], 'Escherichia': [1597], 'yeast': [1600, 2031, 2100, 4472], '(Pichia': [1601], 'pastoris).': [1602], 'inhibits': [1604, 1618], 'neovascularization': [1605], 'two': [1612, 3476], 'model': [1614], 'systems.': [1615], 'previously': [1628, 1747, 1843, 1901, 1988, 2038, 2106, 2215, 2241, 2390, 2507, 2783, 2879, 3200, 3374, 3488, 3666, 3758], 'full-length': [1632, 1977, 2666], 'tumstatin.': [1633, 4494], 'Results': [1634], 'obtained': [1635, 2325, 2376], 'study': [1639, 1688, 3950], 'predominantly': [1644, 4502], 'β3': [1646], 'subunit': [1647], 'integrin.': [1650], 'Additionally,': [1651], 'αvβ3integrin': [1655], 'independent': [1657], 'vitronectin': [1659, 3549], 'or': [1660, 2365, 2662, 2665, 2774, 2992, 3138, 3428, 3548, 3575, 3591, 3692, 3866, 4100], 'fibronectin': [1661, 2479, 2985, 3252], 'cells,': [1665], 'suggesting': [1666], 'demonstrates': [1690], 'dependent': [1699, 1725], 'disulfide': [1701], 'bond': [1702], 'linkage.': [1703], 'strongly': [1706], 'implicate': [1707], 'use': [1709, 3819], 'possible': [1717], 'drug': [1718], 'diseases': [1724], 'sequence': [1729], 'encoding': [1730], 'mutants': [1732], '(Tum-1–5)': [1733], 'amplified': [1737], 'polymerase': [1739], 'reaction': [1741], 'α3(IV)NCI/pDS': [1744], 'vector': [1745], 'described': [1748, 1844, 1989, 2039, 2107, 2143, 2216, 2242, 2391, 2508, 2784, 2831, 2880, 3157, 3201, 3375, 3489, 3665, 3759], '21Neilson': [1785], 'E.G.': [1786, 2250, 3676], 'Sun': [1789, 2245], 'M.J.': [1790, 2246], 'Gunwar': [1791, 2165], 'Danoff': [1793], 'Mariyama': [1795, 2171], 'Myers': [1797], 'Reeders': [1799, 2167], 'S.T.': [1800, 2168], '1993;': [1806], '268:': [1807], '8402-8405Abstract': [1808], 'resulting': [1816], 'cDNA': [1817], 'fragment': [1818], 'ligated': [1820], 'pET28a(+)': [1822], '(Novagen,': [1823], 'Madison,': [1824], 'WI).': [1825], 'Expression': [1826], 'purification': [1834], 'nickel-nitrilotriacetic': [1836], 'acid-agarose': [1837], 'column': [1838], '(Qiagen)': [1839], 'performed': [1841, 2505, 2871, 3372, 3486, 3663, 3756], 'Amino': [1881], '45–132': [1883, 4483], 'were': [1886, 1949, 2198, 2210, 2278, 2323, 2334, 2586, 2610, 2639, 2673, 2683, 2694, 2716, 2753, 2823, 2870, 2924, 2944, 2975, 2999, 3011, 3062, 3113, 3152, 3244, 3256, 3266, 3311, 3356, 3415, 3421, 3433, 3438, 3464, 3541, 3561, 3583, 3642, 3805, 3810, 3890, 3896, 3905, 3916, 3933, 3939, 3970, 3984, 4070, 4079, 4089, 4123, 4134, 4142, 4149, 4161, 4188, 4195, 4287, 4323, 4356], 'includes': [1891], '9': [1894, 1946], 'amino': [1895, 1906, 1947, 4481, 4488], 'addition': [1898], '(54–132': [1905], 'acids)': [1907], 'additional': [1945], 'added': [1950, 2473, 2769, 2859, 3134, 3605], 'enhance': [1952], 'efficiency': [1954], 'expression.': [1957], 'Only': [1958, 4120], 'soluble': [1959, 4121, 4504], 'low': [1963, 4371], 'endotoxin': [1964, 2555], 'level': [1965, 4441], '(less': [1966], '50': [1968, 2589, 3853], 'enzyme': [1969, 2590], 'units/mg)': [1970], 'used': [1972, 2065, 2551, 3084, 3297, 3337, 3357, 4135, 4334, 4432], 'experiments.': [1975], 'Recombinant': [1976, 2026, 2232], '293': [1982], 'embryonic': [1984], 'kidney': [1985], 'P.': [2033, 2102, 3672], 'pastoris': [2034, 2103], 'method': [2037, 2108, 2877], '(22Dhanabal': [2040, 2109], 'Lombardo': [2048, 2117], 'Iruela-Arispe': [2050, 2119], 'M.L.': [2051, 2120], '189-197PubMed': [2060, 2129], 'pPICZαA': [2063], 'subcloning': [2068], 'so': [2071], 'would': [2074], 'fused': [2076], '6-histidine': [2079, 4460], 'tag.': [2080], 'Site-directed': [2081], '(C126': [2083], 'A126)': [2085], 'facilitate': [2089], 'enhanced': [2090], 'secretion': [2091], '(Tum-5/126C-A).': [2094], 'Human': [2095, 3840], 'endostatin': [2096, 4102], 'some': [2133, 2634, 2747], 'experiments,': [2134, 4233], 'processed': [2137, 3155, 3324], 'reduction': [2139], 'alkylation': [2141], 'elsewhere': [2144, 3158], '(23Crestfield': [2145], 'Moore': [2147], 'Stein': [2149], 'W.H.': [2150], '1963;': [2154], '238:': [2155], '622-627Abstract': [2156], '24Kalluri': [2163], 'Morrison': [2169], 'K.C.': [2170], 'Ebner': [2173], 'K.E.': [2174], 'Noelken': [2175], 'M.E.': [2176], '1991;': [2182], '266:': [2183], '2424-24018Abstract': [2184], 'CDCRGDCFC': [2192], '(RGD-4C)': [2193], 'control': [2195, 3872, 4213, 4235], 'CNGRC': [2197], 'kindly': [2199], 'provided': [2200], 'ILEX': [2202], 'Oncology,': [2203], 'Inc': [2204], '(San': [2205], 'Antonio,': [2206], 'TX).': [2207], 'synthesized': [2211], 'characterized': [2213], '(25Arap': [2217], 'W.': [2218], 'Pasqualini': [2219], 'Ruoslahti': [2221], '1998;': [2224, 3100], '279:': [2225], '377-380Crossref': [2226], '(1836)': [2229], 'analyzed': [2235, 2611, 3063, 4245, 4410], 'SDS-PAGE': [2237, 4511], 'immunoblotting': [2239], '(26Kalluri': [2243], 'Neilson': [2249, 3675], '271:': [2255], '9062-9068Abstract': [2256], '(74)': [2264], 'Goat': [2267], 'anti-rabbit': [2268], 'IgG': [2269, 2272, 4332], 'anti-human': [2271], 'antibody': [2273, 2285, 2294, 2930, 3590, 3636, 3649, 3738, 4259, 4306], 'conjugated': [2274, 2295], 'horseradish': [2276], 'peroxidase': [2277, 2297, 4275], 'purchased': [2279, 2287, 2299, 2444, 3643, 3657], 'Sigma.': [2281, 2301], 'Monoclonal': [2282, 3648], 'anti-polyhistidine': [2283, 2292], 'tag': [2284, 2293, 4461], 'Invitrogen,': [2289], 'monoclonal': [2291, 3635, 3721, 4258], 'Bovine': [2302], '(C-PAE),': [2307], '(HUVEC),': [2313], 'adenocarcinoma': [2316], 'line': [2318, 2373], '(PC-3),': [2319], 'NIH3T3': [2321], 'fibroblasts': [2322], 'all': [2324, 2583, 4232], 'American': [2327, 2446], 'Culture': [2329, 2448], 'Collection.': [2330], 'lines': [2333], 'maintained': [2335, 2388, 2451], 'DMEM': [2337, 2453, 2468, 2490, 2645, 2657, 2760, 3120, 3276], '(C-PAE;': [2338], 'Life': [2339, 3645], 'Technologies,': [2340, 3646], 'Inc.)': [2341], 'supplemented': [2342, 2454], '10%': [2344, 2456, 2647, 3122, 3131], '(FCS),': [2348], '100': [2349, 2354, 3564, 3598], 'units/ml': [2350, 3849], 'penicillin,': [2352], 'mg/ml': [2355, 3565], 'streptomycins;': [2357], 'EGM-2': [2359], '(HUVEC;': [2360], 'Clonetics,': [2361], 'San': [2362, 4261], 'Diego,': [2363, 4262], 'CA);': [2364], 'F12K': [2367], '(PC-3;': [2368], 'Cellgro).': [2369], 'WM-164': [2374, 2608], 'Dr.': [2378], 'Meenhard': [2379], 'Herlyn': [2380], 'Wistar': [2383], 'Institute': [2384], '(Philadelphia,': [2385], 'PA)': [2386], '27Herlyn': [2414], 'D.': [2415, 2417], 'Iliopoulos': [2416], 'Jensen': [2418], 'P.J.': [2419], 'Parmiter': [2420], 'Baird': [2422], 'Hotta': [2424], 'Adachi': [2426], 'Ross': [2428], 'A.H.': [2429], 'Jambrosic': [2430], 'Koprowski': [2432], 'et': [2434], 'al.Cancer': [2435], '50:': [2438], '2296-2302PubMed': [2439], 'DU-145': [2442], 'Collection': [2449], 'FCS.': [2457, 2648, 2763, 3123], 'A': [2458, 3330, 4440], 'suspension': [2459], 'C-PAE': [2461, 2637, 2749, 2821, 2942, 3239], '(7,000': [2463], 'cells/well,': [2464], 'passage': [2465], '2–6)': [2466], 'containing': [2469, 2491, 2646, 2658, 2761, 3021, 3121, 3130, 3280, 4313], '0.5%': [2470], 'FCS': [2471, 2493, 2660, 2988, 3023, 3132], 'onto': [2474, 2641, 2825, 2860, 3115, 3606, 3696], '96-well': [2475, 2642, 2757, 2826, 3413, 3539, 3698], 'plates': [2476, 2643, 2672, 2715, 2827, 3414, 3540, 3608], 'precoated': [2477, 3250], '(Sigma,': [2480, 2547], '10': [2481, 3544, 3587, 3867], 'μg/ml).': [2482, 3059, 3254], 'After': [2483, 2994, 3143, 3302, 3617], '24': [2484, 2773, 3261, 3287, 3303, 3441], 'h,': [2485, 2500, 2776, 2996, 3051, 3262, 3304], 'replaced': [2488, 2655], '20%': [2492], 'Tum-5.': [2496], 'Then,': [2497, 3597], 'after': [2498, 3886, 4321, 4506], '36–48': [2499], 'methylene': [2501, 2874, 3627], 'blue': [2502, 2875, 3628], 'staining': [2503, 2876, 3054, 4340], 'Polymyxin': [2545], 'B': [2546], '5': [2548, 3862], 'μg/ml)': [2549, 2837, 2939, 3042, 3283], 'inactivate': [2553], 'any': [2554], 'still': [2558], '(28Liu': [2560], 'Tobias': [2562], 'McClure': [2564], 'Styba': [2566], 'Shi': [2568], 'Q.': [2569], 'Jackowski': [2570], 'Clin': [2572], '30:': [2575], '455-463Crossref': [2576], '(295)': [2579], 'Scholar),': [2581], 'although': [2582], 'samples': [2584], 'tested': [2585], 'less': [2587], 'units/mg': [2591], 'endotoxin,': [2593], 'concentration': [2595, 3555], 'enough': [2599], 'affect': [2601], '(data': [2605], 'shown).': [2607], 'similar': [2614], 'protocol.': [2615], 'BrdUrd': [2617, 2624, 2689], 'incorporation': [2618], 'conducted': [2621], 'kit': [2627, 4350], 'according': [2628, 2739], "manufacturer's": [2630, 3327], 'instructions': [2631, 2742], '(Calbiochem)': [2632], 'modifications.': [2635, 2748], 'Briefly,': [2636, 3108, 3238], 'seeded': [2640, 3114, 3422], 'next': [2650, 2765, 3126], 'day': [2651, 4093, 4173], '2%': [2659, 3022], 'without': [2663], '(293': [2668, 3689], 'expressed).': [2670], 'then': [2674, 2695, 2708, 3002, 3028, 3264, 4080, 4288, 4373, 4390], 'incubated': [2675, 2771, 2839, 2864, 3285, 3434, 3439, 3584, 3610, 4317], '46': [2677], 'h': [2678, 2687, 2933, 2955, 3145, 3442, 4320], 'pulsed': [2684], '2': [2686, 3572, 3973, 4319], '(10': [2690, 3253, 3282], 'nm).': [2691], 'cells/DNA': [2693], 'fixed': [2696, 3003, 3009, 3899], 'wells,': [2699], 'reacted': [2700], 'anti-BrdUrd': [2702], 'primary': [2703], 'secondary': [2705, 3737], 'antibodies': [2706, 3722], 'developed': [2709, 3732], 'colorimetric': [2712], 'reaction.': [2713], 'read': [2717, 3740], 'atA450': [2718], 'nm': [2719], 'Molecular': [2722, 2744], 'Devices': [2723], 'plate': [2724, 2758, 2982, 3118, 3699, 3743], 'reader.': [2725], 'All': [2726, 3807, 3937, 4415], 'groups': [2727, 4083, 4408], 'represent': [2728], 'triplicate': [2729, 3701], 'samples.': [2730], 'viability': [2732, 2779], 'assessed': [2734, 4363], 'MTT': [2736], '(Chemicon)': [2737, 2848, 3714], 'manufacturer': [2741], '(Roche': [2743], 'Biochemicals)': [2745], '(5,000': [2751, 3419], 'cells/well)': [2752, 3420], 'plated': [2754, 2824, 2925, 2978, 3245], '5%': [2762, 2987, 4326], 'day,': [2766, 3127], '48': [2775, 2866, 2951], 'evaluated': [2781], 'serum-depleted': [2829], 'above.': [2832], '(final': [2834, 2936], 'concentration,': [2835, 2937], '20': [2836, 2938, 3848, 4115], 'varying': [2841], 'concentrations': [2842], '30': [2850, 3017, 4283, 4299], 'min': [2851, 3018, 3613, 4300], 'room': [2853, 3014, 4302], 'temperature,': [2854], 'mixture': [2857, 3881], 'h.': [2867, 2952, 3288, 3573], 'Proliferation': [2868], 'assays': [2869], 'experiments': [2918], 'anti-αvβ3': [2920], 'antibody,': [2922], 'preincubated': [2927], 'before': [2934], 'added.': [2941, 3716], 'arrested': [2946], 'contact': [2948], 'inhibition': [2949, 4227], '0': [2954], 'value': [2956], 'refers': [2957], 'percentage': [2960], 'phase': [2965], 'point.': [2969], '(0.1': [2972], '×': [2973, 3111, 3242, 3320, 3578, 3974, 3999, 4001, 4216], '106/well)': [2974, 3112, 3243], 'harvested': [2976, 3000, 3153], '12-well': [2981], 'coated': [2983, 3542, 3695], 'Tum-5/126C-A.': [2993], '21': [2995], '70%': [3005], 'ice-cold': [3006], 'ethanol.': [3007], 'rehydrated': [3012], 'temperature': [3015], 'PBS': [3020, 3291], '0.1%': [3025, 4314], 'Tween-20': [3026], 'centrifuged': [3029], 'resuspended': [3031], '0.5': [3033], 'ml': [3034], 'same': [3037], 'buffer.': [3038, 3292], 'RNase': [3039], 'digestion': [3040], '(5': [3041, 3058], 'carried': [3044, 4342], 'out': [3045, 4343], '37': [3047, 3444, 3615], '°C': [3048], 'followed': [3052], 'propidium': [3056], 'iodide': [3057], 'Coulter': [3066], 'EPICS': [3067], 'XL-MCL': [3068], 'flow': [3069], 'cytometer.': [3070], 'Annexin': [3071], 'V,': [3072], 'calcium-dependent': [3074], 'phospholipid-binding': [3075], 'high': [3079, 3929], 'affinity': [3080], 'phosphatidylserine,': [3082], 'detect': [3086], '(29van': [3088], 'Engeland': [3089], 'Nieland': [3091], 'L.J.': [3092], 'Ramaekers': [3093], 'F.C.': [3094], 'Schutte': [3095], 'B.': [3096], 'Reutelingsperger': [3097], 'C.P.': [3098], 'Cytometry.': [3099], '31:': [3101], '1-9Crossref': [3102], '(1502)': [3105], '(0.5': [3110], '6-well': [3117], 'On': [3124], 'fresh': [3128], 'together': [3135], '80': [3139], 'ng/ml': [3140, 3854], 'TNF-α.': [3142], '18': [3144], 'treatment,': [3147], 'floating': [3148], 'attached': [3150, 3309, 3622], 'Caspase-3': [3195], '(0.4': [3241], '60-mm': [3247], 'Petri': [3248], 'dishes': [3249], 'Cells': [3255, 3437], 'serum-starved': [3257], '(2%': [3258, 3277], 'FCS)': [3259, 3278], 'stimulated': [3267], 'basic': [3269], 'fibroblast': [3270], '(3': [3273], 'ng/ml)': [3274, 3295], 'Controls': [3289], 'received': [3290, 4237], 'TNF-α': [3293], '(80': [3294], 'control.': [3301, 4338], 'supernatant': [3307], 'combined,': [3312], 'equal': [3315, 3706], 'number': [3316, 3448, 3468, 3620, 3923, 4385], '(4': [3319], '107': [3321], 'cells/ml)': [3322], 'following': [3325], 'instruction': [3328], '(CLONTECH).': [3329], 'specific': [3331], 'caspase-3,': [3334], 'DEVD-fmk': [3335], 'specificity.': [3339], 'absorbance': [3341, 3746], 'measured': [3343, 3985], 'microplate': [3346], 'reader': [3347, 3744], '(Bio-Rad)': [3348], '405': [3350, 3748], 'nm.': [3351, 3749], 'Similarly': [3352], 'analyzed.': [3359], 'This': [3360, 3483], 'repeated': [3363], 'times.': [3365], 'Matrigel-precoated': [3412], 'used,': [3416], 'HUVECs': [3418, 3574], 'presence': [3425], 'Control': [3431, 3630], 'PBS.': [3436, 4119], '°C,': [3445], 'tubes': [3450], 'counted': [3452, 3472, 3934], 'microscope': [3455], '(magnification': [3456], '3.3×': [3458], 'ocular,': [3459], '10×': [3460], 'objective).': [3461], 'Three': [3462], 'wells': [3463], 'viewed,': [3465], 'tubes/well': [3470], 'averaged': [3474], 'investigators': [3477], 'blinded': [3478, 3948], 'experimental': [3481], 'protocols.': [3482, 3951], '30Senger': [3512], 'D.R.': [3513], 'Claffey': [3514], 'K.P.': [3515], 'Benes': [3516], 'J.E.': [3517], 'Perruzzi': [3518], 'C.A.': [3519], 'Sergiou': [3520], 'A.P.': [3521], 'Detmar': [3522], 'Proc.': [3524], 'Natl.': [3525], 'Acad.': [3526], 'Sci.': [3527], 'U.': [3528], '94:': [3532], '13612-13617Crossref': [3533], '(451)': [3536], 'μg/ml': [3545, 3558, 3588, 3863, 3868], '(Collaborative': [3550, 3843], 'Biomedical': [3551], 'Products)': [3552], '0.5–2.5': [3557], 'overnight.': [3559], 'Plates': [3560], 'blocked': [3562, 4278, 4324], 'albumin': [3569], '(Sigma)': [3570], 'C-PAEs': [3576], '(1.5': [3577], '105': [3579], 'cells/ml,': [3580], 'M-199)': [3582], 'either': [3586], 'synthetic': [3592], 'peptide': [3593], '15': [3595], 'min.': [3596], 'μl': [3599], 'suspension/well': [3603], '45': [3612], '°C.': [3616], 'washing,': [3618], 'staining.': [3629], 'mouse': [3631, 3634], 'IgG1': [3632], 'β1integrin': [3639], '(clone': [3640, 3654, 3726], 'P4C10)': [3641], 'Inc.': [3647], 'LM609)': [3655], 'Chemicon.': [3659], 'Direct': [3660], 'ELISA': [3661, 3730], '(31Kalluri': [3667], 'Shield': [3669], 'C.F.': [3670], 'Todd': [3671], 'Clin.': [3678], 'Invest.': [3679], '99:': [3681], '2470-2478Crossref': [3682], '(258)': [3685], 'Tumstatin': [3688], 'expressed)': [3691], '(100': [3702], 'ng/well),': [3703], 'amount': [3708], 'Binding': [3717], 'established': [3719], 'LM609,': [3727], 'Chemicon).': [3728], 'alkaline': [3735], 'phosphatase': [3736], '5–6-week-old': [3796], 'male': [3797], 'C57/BL6': [3798], '(Jackson': [3800], 'Laboratories,': [3801], 'Bar': [3802], 'Harbor,': [3803], 'ME)': [3804], 'obtained.': [3806], 'animal': [3808, 3816], 'reviewed': [3811], 'approved': [3813], 'care': [3817], 'committee': [3820], 'Beth': [3822], 'Israel': [3823], 'Deaconess': [3824], 'Medical': [3825], 'Center': [3826], 'accordance': [3830], 'guidelines': [3833], 'Department': [3836], 'Health': [3838], 'Services.': [3841], 'Biomolecules)': [3844], 'mixed': [3846], 'heparin': [3851], '(Pierce),': [3852], '(R&D),': [3860], 'Tum-1.': [3870], 'group': [3873, 3953, 4236], 'did': [3874], 'receive': [3876], 'proteins.': [3878], 'injected': [3883, 4105], 'subcutaneously,': [3884], '6': [3887, 4085], 'days': [3888, 4116], 'sacrificed,': [3891, 4191], 'plugs': [3895, 3904], 'removed': [3897], '4%': [3901], 'paraformaldehyde.': [3902], 'embedded': [3906], 'paraffin,': [3908], 'sectioned,': [3909], 'hematoxylin': [3911], 'eosin': [3913], 'stained.': [3914], 'Sections': [3915, 4355], 'light': [3919, 4200], 'microscopy,': [3920], '4–7': [3928], 'power': [3930], 'fields': [3931], '(×400)': [3932], 'averaged.': [3936], 'sections': [3938, 4248, 4322], 'coded': [3940], 'observed': [3942], 'investigator': [3945], 'who': [3946], 'Each': [3952], 'consists': [3954], 'four': [3956], 'plugs.': [3958], 'Male': [3959], 'athymic': [3960], 'NCRNU': [3962], 'mice,': [3963], '5–6': [3964], 'weeks': [3965], 'old,': [3966], 'weighing': [3967], '∼25': [3968], 'g': [3969], 'implanted': [3971, 4132], '106': [3975], 'dorsal': [3980], 'subcutis.': [3981], 'Vernier': [3987], 'calipers,': [3988], 'volume': [3991, 4171], 'calculated': [3993], 'standard': [3996, 4266], 'formula': [3997], '(width2': [3998], 'length': [4000], '0.52)': [4002], "Scholar,4O'Reilly": [4034], 'allowed': [4071], 'grow': [4073], '∼50': [4075], 'mm3,': [4076], 'animals': [4078], 'pair-matched': [4081], 'Initial': [4087], 'doses': [4088, 4109], 'given': [4090], 'pair-matching': [4095], '(Day': [4096, 4184], '1).': [4097], 'Tum-5/126C-A,': [4099], 'intraperitoneally': [4104], 'twice': [4106, 4144, 4151], 'daily': [4107], 'ranging': [4110], '1–20': [4112], 'sterile': [4118], 'proteins': [4122], 'used.': [4124], 'continuous': [4127], 'delivery': [4128], 'Alzetmini-pumps': [4130], 'surgically': [4131], 'subcutaneously': [4133], 'group.': [4140, 4230], 'Mice': [4141], 'weighed': [4143, 4189], 'weekly,': [4145, 4152], 'measurements': [4148], 'taken': [4150], 'starting': [4153], 'Day': [4155], '1.': [4156], 'Estimated': [4157], 'mean': [4158, 4209, 4401], 'volumes': [4160], 'plotted': [4162], 'ratio': [4165], '(V/Vo),': [4166], 'where': [4167], 'V': [4168], '=': [4169, 4178], 'measurement': [4175], 'Vo': [4177], 'initial': [4179], 'volume.': [4181], 'Upon': [4182], 'termination': [4183], '21),': [4185], 'their': [4193], 'excised': [4196], 'microscopy': [4201], 'immunostaining.': [4204], 'model,': [4207], 'treated': [4210], 'weight)/(mean': [4212], 'weight)': [4215], '100%': [4217, 4221], 'subtracted': [4219], 'give': [4223], 'each': [4229], 'vehicle': [4238], 'injection.': [4239], 'Intratumoral': [4240], '(MVD)': [4243], 'frozen': [4247], 'rat': [4255, 4331], 'anti-mouse': [4256], 'CD-31': [4257], '(Pharmingen,': [4260], 'CA)': [4263], 'streptavidin-biotin-peroxidase': [4267], 'detection': [4268], 'system': [4269], '(Vectastain': [4270], 'ABC': [4271, 4347], 'Elite': [4272, 4348], 'kit).': [4273], 'Endogenous': [4274], '1%': [4280], 'H2O2/methanol': [4281], 'min,': [4284], 'slides': [4286], 'subjected': [4289], 'antigen': [4291], 'retrieval': [4292], 'incubating': [4294], 'proteinase': [4296], 'K': [4297], 'temperature.': [4303], 'Anti-mouse': [4304], 'diluted': [4308], '1:20': [4309], 'PBS-T': [4311], '(PBS': [4312], 'Tween-20)': [4315], 'normal': [4327], 'goat': [4328], 'serum/PBS-T.': [4329], 'Normal': [4330], 'Immunoperoxidase': [4339], 'utilizing': [4344], 'Vectastain': [4346], 'reagent': [4349], '(Vector': [4351], 'Labs,': [4352], 'Burlingame,': [4353], 'CA).': [4354], 'counterstained': [4357], 'Methyl': [4359], 'green.': [4360], 'MVD': [4361], 'scanning': [4367], 'power,': [4372], 'identifying': [4374], 'areas': [4376], 'periphery': [4380], 'contain': [4382], 'maximum': [4384], 'discrete': [4387], 'microvessels,': [4388], 'counting': [4391], 'individual': [4392], 'microvessels': [4393], 'lower': [4396], 'magnification': [4397], '(40×)': [4398], 'field.': [4399], 'compared': [4405], 'among': [4406], "Student's": [4412, 4429], 't': [4413], 'test.': [4414], 'values': [4416], 'means': [4420], '±': [4421], 'S.E.': [4422], 'Analysis': [4423], 'variance': [4425], 'one-tailed': [4428], 'ttest': [4430], 'identify': [4434], 'differences': [4436], 'multiple': [4438], 'comparisons.': [4439], 'p': [4443], '<': [4444], '0.05': [4445], 'considered': [4447], 'statistically': [4448], 'significant.': [4449], 'fusion': [4455], 'coliusing': [4464], 'expression': [4466], 'plasmid': [4467, 4474], 'pET': [4468], '28a': [4469], 'pPICZαA.': [4475], 'encompass': [4480], 'include': [4485], '54–132': [4490], 'isolated': [4501], 'refolding': [4508], 'process,': [4509]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2052891209', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-10T04:40:06.093575', 'created_date': '2016-06-24'}
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