Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2052373655', 'doi': 'https://doi.org/10.1016/s0008-6363(01)00521-1', 'title': 'Signal transduction systems and atrial fibrillation', 'display_name': 'Signal transduction systems and atrial fibrillation', 'publication_year': 2002, 'publication_date': '2002-05-01', 'ids': {'openalex': 'https://openalex.org/W2052373655', 'doi': 'https://doi.org/10.1016/s0008-6363(01)00521-1', 'mag': '2052373655', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12062330'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0008-6363(01)00521-1', 'pdf_url': 'https://academic.oup.com/cardiovascres/article-pdf/54/2/247/757061/54-2-247.pdf', 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/cardiovascres/article-pdf/54/2/247/757061/54-2-247.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110529942', 'display_name': 'Andreas Goette', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210138551', 'display_name': 'University Hospital Magdeburg', 'ror': 'https://ror.org/03m04df46', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210138551']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'A Goette', 'raw_affiliation_strings': ['Division of Cardiology, Department of Internal Medicine, University Hospital Magdeburg, Leipzigerstr. 44, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Division of Cardiology, Department of Internal Medicine, University Hospital Magdeburg, Leipzigerstr. 44, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I4210138551']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5110529942'], 'corresponding_institution_ids': ['https://openalex.org/I4210138551'], 'apc_list': {'value': 4177, 'currency': 'EUR', 'value_usd': 4504, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.855, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 84, 'citation_normalized_percentile': {'value': 0.805104, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '54', 'issue': '2', 'first_page': '247', 'last_page': '258'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10065', 'display_name': 'Atrial Fibrillation Management and Outcomes', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10065', 'display_name': 'Atrial Fibrillation Management and Outcomes', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/second-messenger-system', 'display_name': 'Second messenger system', 'score': 0.822006}, {'id': 'https://openalex.org/keywords/transduction', 'display_name': 'Transduction (biophysics)', 'score': 0.43389574}], 'concepts': [{'id': 'https://openalex.org/C163235415', 'wikidata': 'https://www.wikidata.org/wiki/Q899814', 'display_name': 'Second messenger system', 'level': 3, 'score': 0.822006}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.77041435}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.7373283}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.61279947}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49046585}, {'id': 'https://openalex.org/C185263204', 'wikidata': 'https://www.wikidata.org/wiki/Q1154774', 'display_name': 'Electrophysiology', 'level': 2, 'score': 0.48687592}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.47625566}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.475984}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.47388074}, {'id': 'https://openalex.org/C15152581', 'wikidata': 'https://www.wikidata.org/wiki/Q7833966', 'display_name': 'Transduction (biophysics)', 'level': 2, 'score': 0.43389574}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16066608}], 'mesh': [{'descriptor_ui': 'D001281', 'descriptor_name': 'Atrial Fibrillation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001281', 'descriptor_name': 'Atrial Fibrillation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001281', 'descriptor_name': 'Atrial Fibrillation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006984', 'descriptor_name': 'Hypertrophy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015290', 'descriptor_name': 'Second Messenger Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015290', 'descriptor_name': 'Second Messenger Systems', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0008-6363(01)00521-1', 'pdf_url': 'https://academic.oup.com/cardiovascres/article-pdf/54/2/247/757061/54-2-247.pdf', 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12062330', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0008-6363(01)00521-1', 'pdf_url': 'https://academic.oup.com/cardiovascres/article-pdf/54/2/247/757061/54-2-247.pdf', 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 107, 'referenced_works': ['https://openalex.org/W106666432', 'https://openalex.org/W1547181084', 'https://openalex.org/W1661180389', 'https://openalex.org/W1763096406', 'https://openalex.org/W1764686129', 'https://openalex.org/W1769585641', 'https://openalex.org/W1821505083', 'https://openalex.org/W1849816754', 'https://openalex.org/W1963495404', 'https://openalex.org/W1970750802', 'https://openalex.org/W1972902327', 'https://openalex.org/W1974279158', 'https://openalex.org/W1978231615', 'https://openalex.org/W1978963482', 'https://openalex.org/W1984212762', 'https://openalex.org/W1984992817', 'https://openalex.org/W1993059359', 'https://openalex.org/W1993549735', 'https://openalex.org/W1994441999', 'https://openalex.org/W1998081634', 'https://openalex.org/W1999788892', 'https://openalex.org/W1999850772', 'https://openalex.org/W1999998552', 'https://openalex.org/W2000040025', 'https://openalex.org/W2005874915', 'https://openalex.org/W2006227135', 'https://openalex.org/W2010588716', 'https://openalex.org/W2010876561', 'https://openalex.org/W2015639803', 'https://openalex.org/W2017179259', 'https://openalex.org/W2020103404', 'https://openalex.org/W2024137231', 'https://openalex.org/W2024420623', 'https://openalex.org/W2026362575', 'https://openalex.org/W2029045834', 'https://openalex.org/W2029652412', 'https://openalex.org/W2029827227', 'https://openalex.org/W2033861216', 'https://openalex.org/W2034282563', 'https://openalex.org/W2036043090', 'https://openalex.org/W2036226118', 'https://openalex.org/W2038843437', 'https://openalex.org/W2041792559', 'https://openalex.org/W2042053234', 'https://openalex.org/W2042601656', 'https://openalex.org/W2043448209', 'https://openalex.org/W2044427990', 'https://openalex.org/W2047537912', 'https://openalex.org/W2050982071', 'https://openalex.org/W2051992417', 'https://openalex.org/W2058755393', 'https://openalex.org/W2059834495', 'https://openalex.org/W2064179005', 'https://openalex.org/W2066283094', 'https://openalex.org/W2067165506', 'https://openalex.org/W2067261829', 'https://openalex.org/W2067341425', 'https://openalex.org/W2067849742', 'https://openalex.org/W2068359901', 'https://openalex.org/W2073094871', 'https://openalex.org/W2074522029', 'https://openalex.org/W2077956363', 'https://openalex.org/W2079255926', 'https://openalex.org/W2081498945', 'https://openalex.org/W2082272659', 'https://openalex.org/W2084330407', 'https://openalex.org/W2085014473', 'https://openalex.org/W2088742606', 'https://openalex.org/W2089853340', 'https://openalex.org/W2089940123', 'https://openalex.org/W2091790802', 'https://openalex.org/W2095715381', 'https://openalex.org/W2096737170', 'https://openalex.org/W2096984112', 'https://openalex.org/W2097501580', 'https://openalex.org/W2099601272', 'https://openalex.org/W2101201730', 'https://openalex.org/W2101305687', 'https://openalex.org/W2101345537', 'https://openalex.org/W2101622006', 'https://openalex.org/W2102450596', 'https://openalex.org/W2104742289', 'https://openalex.org/W2106015949', 'https://openalex.org/W2109425462', 'https://openalex.org/W2119119479', 'https://openalex.org/W2119608885', 'https://openalex.org/W2119897029', 'https://openalex.org/W2122639201', 'https://openalex.org/W2126066210', 'https://openalex.org/W2137712934', 'https://openalex.org/W2146774300', 'https://openalex.org/W2151312020', 'https://openalex.org/W2152669066', 'https://openalex.org/W2157756663', 'https://openalex.org/W2164029652', 'https://openalex.org/W2164375876', 'https://openalex.org/W2171083892', 'https://openalex.org/W2316067769', 'https://openalex.org/W2321600818', 'https://openalex.org/W2324258168', 'https://openalex.org/W2331176038', 'https://openalex.org/W2411896874', 'https://openalex.org/W2429202206', 'https://openalex.org/W2614496215', 'https://openalex.org/W2793438318', 'https://openalex.org/W2886677771', 'https://openalex.org/W98960407'], 'related_works': ['https://openalex.org/W79799839', 'https://openalex.org/W3181722030', 'https://openalex.org/W3142360368', 'https://openalex.org/W2797952716', 'https://openalex.org/W2586673537', 'https://openalex.org/W2169979796', 'https://openalex.org/W2091044919', 'https://openalex.org/W2072051533', 'https://openalex.org/W2050121373', 'https://openalex.org/W1998606603'], 'abstract_inverted_index': {'Cell': [0], 'communication,': [1], 'an': [2], 'essential': [3], 'component': [4], 'of': [5, 54, 58, 67, 84], 'integrated': [6], 'physiological': [7], 'function': [8], 'in': [9, 89], 'multicellular': [10], 'organisms,': [11], 'is': [12, 46], 'mediated': [13], 'largely': [14], 'through': [15], 'informational': [16], 'molecules,': [17], 'such': [18], 'as': [19], 'hormones': [20], 'and': [21, 51, 82], 'neurotransmitters.': [22], 'After': [23], 'binding': [24], 'to': [25, 62, 65], 'specific': [26], 'receptors,': [27], 'these': [28, 59], 'first': [29], 'messengers': [30], 'activate': [31], 'intracellular': [32, 42], 'signaling': [33], 'cascades': [34], 'and,': [35], 'thereby,': [36], 'translate': [37], 'extracellular': [38], 'messenger': [39], 'levels': [40], 'into': [41], 'events.': [43], 'Atrial': [44], 'fibrillation': [45], 'associated': [47], 'with': [48], 'significant': [49], 'electrophysiological': [50], 'structural': [52], 'alterations': [53], 'atrial': [55, 74], 'tissue.': [56], 'Most': [57], 'changes': [60], 'seem': [61], 'be': [63], 'related': [64], 'activation': [66], 'signal': [68, 86], 'transduction': [69, 87], 'systems': [70, 88], 'at': [71], 'the': [72, 80], 'molecular': [73], 'level.': [75], 'This': [76], 'review': [77], 'will': [78], 'describe': [79], 'role': [81], 'regulation': [83], 'different': [85], 'fibrillating': [90], 'atria.': [91]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2052373655', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-31T12:07:59.677419', 'created_date': '2016-06-24'}