Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2052335617', 'doi': 'https://doi.org/10.1016/j.febslet.2006.07.054', 'title': 'Copper complexes of (−)‐epicatechin gallate and (−)‐epigallocatechin gallate act as inhibitors of Ribonuclease A', 'display_name': 'Copper complexes of (−)‐epicatechin gallate and (−)‐epigallocatechin gallate act as inhibitors of Ribonuclease A', 'publication_year': 2006, 'publication_date': '2006-07-25', 'ids': {'openalex': 'https://openalex.org/W2052335617', 'doi': 'https://doi.org/10.1016/j.febslet.2006.07.054', 'mag': '2052335617', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16884715'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2006.07.054', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2006.07.054', 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2006.07.054', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035005408', 'display_name': 'Kalyan Sundar Ghosh', 'orcid': 'https://orcid.org/0000-0001-7220-7818'}, 'institutions': [{'id': 'https://openalex.org/I145894827', 'display_name': 'Indian Institute of Technology Kharagpur', 'ror': 'https://ror.org/03w5sq511', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I145894827']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Kalyan Sundar Ghosh', 'raw_affiliation_strings': ['Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India', 'institution_ids': ['https://openalex.org/I145894827']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086881458', 'display_name': 'Tushar Kanti Maiti', 'orcid': 'https://orcid.org/0000-0003-4721-827X'}, 'institutions': [{'id': 'https://openalex.org/I145894827', 'display_name': 'Indian Institute of Technology Kharagpur', 'ror': 'https://ror.org/03w5sq511', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I145894827']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Tushar Kanti Maiti', 'raw_affiliation_strings': ['Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India', 'institution_ids': ['https://openalex.org/I145894827']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010099982', 'display_name': 'Abhishek Mandal', 'orcid': 'https://orcid.org/0000-0002-8982-9696'}, 'institutions': [{'id': 'https://openalex.org/I145894827', 'display_name': 'Indian Institute of Technology Kharagpur', 'ror': 'https://ror.org/03w5sq511', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I145894827']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Abhishek Mandal', 'raw_affiliation_strings': ['Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India', 'institution_ids': ['https://openalex.org/I145894827']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020262211', 'display_name': 'Swagata Dasgupta', 'orcid': 'https://orcid.org/0000-0003-2074-1247'}, 'institutions': [{'id': 'https://openalex.org/I145894827', 'display_name': 'Indian Institute of Technology Kharagpur', 'ror': 'https://ror.org/03w5sq511', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I145894827']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Swagata Dasgupta', 'raw_affiliation_strings': ['Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Indian institute of Technology,Kharagpur 721302,India', 'institution_ids': ['https://openalex.org/I145894827']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.847, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.826468, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '580', 'issue': '19', 'first_page': '4703', 'last_page': '4708'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11411', 'display_name': 'Health Effects of Tea Polyphenols', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11411', 'display_name': 'Health Effects of Tea Polyphenols', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14285', 'display_name': 'Microbial Production of Polyglutamic Acid', 'score': 0.9686, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11882', 'display_name': 'Biosynthesis and Engineering of Terpenoids', 'score': 0.9614, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gallate', 'display_name': 'Gallate', 'score': 0.8222202}, {'id': 'https://openalex.org/keywords/agarose-gel-electrophoresis', 'display_name': 'Agarose gel electrophoresis', 'score': 0.5310894}, {'id': 'https://openalex.org/keywords/propyl-gallate', 'display_name': 'Propyl gallate', 'score': 0.5147693}, {'id': 'https://openalex.org/keywords/epicatechin-gallate', 'display_name': 'Epicatechin gallate', 'score': 0.4955343}, {'id': 'https://openalex.org/keywords/tea-polyphenols', 'display_name': 'Tea Polyphenols', 'score': 0.488237}, {'id': 'https://openalex.org/keywords/agarose', 'display_name': 'Agarose', 'score': 0.44600335}, {'id': 'https://openalex.org/keywords/copper-protein', 'display_name': 'Copper protein', 'score': 0.42863205}], 'concepts': [{'id': 'https://openalex.org/C2780295536', 'wikidata': 'https://www.wikidata.org/wiki/Q11682030', 'display_name': 'Gallate', 'level': 2, 'score': 0.8222202}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.79469556}, {'id': 'https://openalex.org/C2777192995', 'wikidata': 'https://www.wikidata.org/wiki/Q393339', 'display_name': 'Epigallocatechin gallate', 'level': 4, 'score': 0.76075965}, {'id': 'https://openalex.org/C70899900', 'wikidata': 'https://www.wikidata.org/wiki/Q290439', 'display_name': 'Polyphenol', 'level': 3, 'score': 0.61357194}, {'id': 'https://openalex.org/C10879258', 'wikidata': 'https://www.wikidata.org/wiki/Q76826611', 'display_name': 'RNase P', 'level': 4, 'score': 0.599563}, {'id': 'https://openalex.org/C2778976237', 'wikidata': 'https://www.wikidata.org/wiki/Q422523', 'display_name': 'Ribonuclease', 'level': 4, 'score': 0.5379513}, {'id': 'https://openalex.org/C2778271344', 'wikidata': 'https://www.wikidata.org/wiki/Q903395', 'display_name': 'Agarose gel electrophoresis', 'level': 3, 'score': 0.5310894}, {'id': 'https://openalex.org/C2780162734', 'wikidata': 'https://www.wikidata.org/wiki/Q608726', 'display_name': 'Propyl gallate', 'level': 3, 'score': 0.5147693}, {'id': 'https://openalex.org/C544778455', 'wikidata': 'https://www.wikidata.org/wiki/Q753', 'display_name': 'Copper', 'level': 2, 'score': 0.50499207}, {'id': 'https://openalex.org/C2777787921', 'wikidata': 'https://www.wikidata.org/wiki/Q5382492', 'display_name': 'Epicatechin gallate', 'level': 5, 'score': 0.4955343}, {'id': 'https://openalex.org/C133571119', 'wikidata': 'https://www.wikidata.org/wiki/Q899102', 'display_name': 'Circular dichroism', 'level': 2, 'score': 0.4908846}, {'id': 'https://openalex.org/C116084860', 'wikidata': 'https://www.wikidata.org/wiki/Q48255', 'display_name': 'Gel electrophoresis', 'level': 2, 'score': 0.47353977}, {'id': 'https://openalex.org/C2778476535', 'wikidata': 'https://www.wikidata.org/wiki/Q390697', 'display_name': 'Agarose', 'level': 2, 'score': 0.44600335}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.43583283}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43193328}, {'id': 'https://openalex.org/C181312439', 'wikidata': 'https://www.wikidata.org/wiki/Q909712', 'display_name': 'Copper protein', 'level': 3, 'score': 0.42863205}, {'id': 'https://openalex.org/C13965031', 'wikidata': 'https://www.wikidata.org/wiki/Q243545', 'display_name': 'Nuclear chemistry', 'level': 1, 'score': 0.22422114}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.1275546}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.12302238}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.065901816}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012259', 'descriptor_name': 'Ribonuclease, Pancreatic', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002392', 'descriptor_name': 'Catechin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012259', 'descriptor_name': 'Ribonuclease, Pancreatic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017550', 'descriptor_name': 'Spectroscopy, Fourier Transform Infrared', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2006.07.054', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2006.07.054', 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16884715', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2006.07.054', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2006.07.054', 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.51, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W121642688', 'https://openalex.org/W1565585976', 'https://openalex.org/W1614488569', 'https://openalex.org/W1644516630', 'https://openalex.org/W1964211194', 'https://openalex.org/W1970501621', 'https://openalex.org/W1977549713', 'https://openalex.org/W1984970966', 'https://openalex.org/W1991046721', 'https://openalex.org/W2001730948', 'https://openalex.org/W2009995040', 'https://openalex.org/W2027026203', 'https://openalex.org/W2039708261', 'https://openalex.org/W2042658641', 'https://openalex.org/W2045616069', 'https://openalex.org/W2046287735', 'https://openalex.org/W2059611030', 'https://openalex.org/W2062102053', 'https://openalex.org/W2066181869', 'https://openalex.org/W2066337561', 'https://openalex.org/W2068125088', 'https://openalex.org/W2076311058', 'https://openalex.org/W2079042729', 'https://openalex.org/W2088286044', 'https://openalex.org/W2106059645', 'https://openalex.org/W2117934439', 'https://openalex.org/W2140260269', 'https://openalex.org/W2151605986', 'https://openalex.org/W2158380218', 'https://openalex.org/W2159426997', 'https://openalex.org/W2212272536', 'https://openalex.org/W4211216439'], 'related_works': ['https://openalex.org/W761006901', 'https://openalex.org/W4293812010', 'https://openalex.org/W3119424115', 'https://openalex.org/W3118377884', 'https://openalex.org/W2410286516', 'https://openalex.org/W2402124306', 'https://openalex.org/W2364627196', 'https://openalex.org/W2073205682', 'https://openalex.org/W2052335617', 'https://openalex.org/W2022414076'], 'abstract_inverted_index': {'Green': [0], 'tea': [1], 'polyphenols,': [2], 'which': [3], 'have': [4], 'the': [5, 34, 71, 76, 80, 88], 'ability': [6], 'to': [7, 32, 60, 84, 87], 'inhibit': [8, 33], 'angiogenesis,': [9], 'form': [10], 'complexes': [11, 23, 57], 'with': [12, 67], 'Cu(II),': [13], 'a': [14], 'known': [15], 'potent': [16], 'stimulator': [17], 'of': [18, 24, 37, 64, 79], 'blood': [19], 'vessel': [20], 'proliferation.': [21], 'Copper': [22], '(−)‐epicatechin': [25], 'gallate': [26, 29], 'and': [27, 50, 96], '(−)‐epigallocatechin': [28], 'were': [30, 58], 'found': [31, 59, 83], 'enzymatic': [35], 'activity': [36], 'Ribonuclease': [38], 'A': [39, 66], '(RNase': [40], 'A)': [41], 'as': [42, 90], 'revealed': [43, 91], 'by': [44], 'an': [45], 'agarose': [46], 'gel': [47, 53], 'based': [48], 'assay': [49], 'urea': [51], 'denatured': [52], 'electrophoresis.': [54], 'The': [55], 'copper': [56], 'be': [61], 'non‐competitive': [62], 'inhibitors': [63], 'RNase': [65], 'inhibition': [68], 'constants': [69], 'in': [70, 75], 'micromolar': [72], 'range.': [73], 'Changes': [74], 'secondary': [77], 'structure': [78], 'protein': [81], 'are': [82], 'occur': [85], 'due': [86], 'interaction': [89], 'from': [92], 'Fourier': [93], 'transform': [94], 'infrared': [95], 'circular': [97], 'dichroism': [98], 'studies.': [99]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2052335617', 'counts_by_year': [{'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-14T00:12:26.376125', 'created_date': '2016-06-24'}