Differential Effects of the SR Proteins 9G8, SC35, ASF/SF2, and SRp40 on the Utilization of the A1 to A5 Splicing Sites of HIV-1 RNA

Name: Work Video:
Duration: 3 min 30 s
Delphine Ropers; Lilia Ayadi; Renata Gattoni; S. Jacquenet; Laurence Damier; Christiane Branlant; James Stévenin
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549, 564, 814, 827, 1356, 1403, 1628, 1752, 1788, 1841, 1852, 2286, 2443, 2622, 3537, 3668, 4096, 4162], 'a': [2, 42, 169, 175, 205, 283, 291, 331, 458, 464, 494, 572, 580, 1350, 2004, 2281, 2341, 2656, 2682, 2686, 2735, 3020, 3038, 3492, 3901, 4112, 4163, 4289, 4438, 4444, 4614], 'crucial': [3, 292], 'step': [4, 293], 'for': [5, 294, 583, 674, 681, 698, 1630, 1639, 1663, 1697, 1754, 1758, 1791, 1843, 1847, 2288, 2807, 3095, 3130, 3140, 3151, 3194, 3279, 3362, 3393], 'human': [6, 295, 593, 614], 'immunodeficiency': [7, 296, 594, 615], 'virus,': [8, 297, 595, 616], 'type': [9, 298, 596, 617], '1': [10, 299, 4267], '(HIV-1)': [11, 300], 'multiplication;': [12, 301], 'eight': [13, 302, 740, 2456], 'acceptor': [14, 121, 146, 303, 410, 435, 808, 953, 1278, 1626, 1895, 2151, 2458, 2500, 2795, 3661], 'sites': [15, 48, 122, 147, 304, 337, 411, 436, 723, 742, 793, 862, 891, 954, 1279, 1451, 1627, 1688, 1896, 2459, 2464, 2673, 2694, 3662, 3677, 3876, 3938, 4174, 4396], 'are': [16, 305, 654, 661, 1280, 1288, 1343, 1637, 1692, 2015, 2059, 3686, 3888, 3913, 4013, 4151], 'used': [17, 306, 590, 611, 1357, 1638, 1693, 2806, 3129, 3150, 3193, 3276, 4451, 4622], 'in': [18, 77, 125, 127, 141, 144, 307, 366, 414, 416, 430, 433, 666, 772, 1347, 1408, 1720, 1779, 1798, 1854, 1868, 2017, 2027, 2062, 2471, 2486, 2489, 2601, 2628, 2674, 2772, 2799, 3146, 3213, 3249, 3294, 3305, 3356, 3363, 3551, 3581, 3592, 3623, 3642, 3671, 3833, 3858, 3910, 3933, 3944, 3963, 3978, 3992, 3999, 4006, 4029, 4037, 4041, 4053, 4059, 4089, 4111, 4115, 4178, 4182, 4200, 4216, 4220, 4235, 4422, 4546], 'competition': [19, 308, 2453], 'to': [20, 153, 168, 212, 252, 309, 442, 457, 501, 541, 663, 670, 695, 725, 801, 806, 817, 821, 865, 893, 899, 1694, 1727, 2023, 2029, 2113, 2144, 2160, 2197, 2624, 2793, 2964, 3034, 3051, 3059, 3138, 3607, 3664, 3900, 4194, 4284, 4288, 4337, 4347, 4355, 4399, 4419, 4424, 4452, 4475, 4623], 'produce': [21, 310, 696, 1695], 'the': [22, 61, 69, 81, 91, 99, 111, 119, 128, 131, 136, 180, 209, 213, 218, 230, 256, 261, 265, 311, 350, 358, 370, 380, 388, 400, 408, 417, 420, 425, 469, 498, 502, 507, 519, 545, 550, 554, 586, 635, 640, 646, 664, 682, 685, 699, 705, 717, 804, 884, 888, 900, 957, 1359, 1446, 1619, 1624, 1644, 1682, 1698, 1721, 1728, 1759, 1766, 1770, 1780, 1848, 1858, 1893, 1903, 1908, 2038, 2044, 2053, 2056, 2063, 2129, 2150, 2155, 2161, 2169, 2173, 2177, 2186, 2192, 2198, 2274, 2277, 2289, 2314, 2318, 2368, 2374, 2446, 2452, 2455, 2492, 2611, 2660, 2667, 2692, 2741, 2770, 2782, 2791, 2810, 2892, 2921, 2958, 3017, 3026, 3052, 3096, 3100, 3197, 3207, 3214, 3280, 3288, 3295, 3311, 3497, 3507, 3531, 3543, 3552, 3555, 3577, 3582, 3585, 3602, 3608, 3624, 3636, 3639, 3651, 3655, 3660, 3848, 3851, 3863, 3870, 3891, 3895, 3908, 3916, 3920, 3927, 3945, 3971, 3979, 3983, 4002, 4028, 4034, 4060, 4065, 4068, 4090, 4116, 4124, 4133, 4136, 4154, 4158, 4170, 4179, 4187, 4195, 4198, 4201, 4204, 4217, 4243, 4285, 4303, 4312, 4330, 4338, 4348, 4358, 4365, 4371, 4377, 4391, 4410, 4454, 4547, 4562, 4568, 4572, 4609], 'vif,': [23, 312], 'vpu,': [24, 313], 'vpr,': [25, 314], 'nef,': [26, 315], 'env,': [27, 316], 'tat,': [28, 317], 'and': [29, 143, 149, 156, 167, 190, 199, 242, 248, 318, 432, 438, 445, 456, 479, 488, 531, 537, 701, 704, 739, 750, 796, 820, 1290, 1346, 1449, 1635, 1662, 1689, 1761, 1774, 1823, 1862, 1929, 1978, 2050, 2086, 2238, 2379, 2460, 2488, 2497, 2617, 2734, 2745, 2786, 2803, 2813, 3037, 3043, 3062, 3248, 3254, 3262, 3266, 3348, 3353, 3396, 3456, 3465, 3483, 3562, 3618, 3659, 3678, 3850, 3869, 3923, 3937, 3942, 3967, 4001, 4131, 4143, 4149, 4176, 4207, 4222, 4271, 4317, 4385, 4393, 4405, 4428, 4443, 4576], 'rev': [30, 319], 'mRNAs.': [31, 221, 320, 510, 4415], 'The': [32, 94, 321, 383, 689, 857, 1890, 2255, 2468, 2954, 3069, 3103, 3385, 3441, 3460, 3534, 3565, 3598, 3666, 3674, 3905, 3988, 4079, 4468, 4538], 'effects': [33, 70, 266, 322, 359, 555, 2136, 2661, 3630, 4022], 'of': [34, 45, 63, 71, 73, 84, 98, 110, 118, 133, 135, 208, 215, 217, 239, 255, 264, 267, 269, 286, 323, 334, 352, 360, 362, 373, 387, 399, 407, 422, 424, 497, 504, 506, 528, 544, 553, 556, 558, 575, 585, 645, 658, 684, 710, 720, 803, 859, 887, 951, 959, 1454, 1621, 1623, 1641, 1643, 1681, 1723, 1756, 1769, 1795, 1845, 1857, 1892, 1897, 1905, 1907, 1955, 2034, 2041, 2047, 2052, 2066, 2131, 2141, 2157, 2168, 2172, 2180, 2185, 2194, 2257, 2276, 2283, 2292, 2313, 2367, 2371, 2373, 2448, 2465, 2494, 2659, 2662, 2670, 2740, 2769, 2790, 2809, 2903, 3072, 3099, 3132, 3196, 3206, 3209, 3217, 3282, 3297, 3346, 3387, 3407, 3443, 3445, 3509, 3521, 3542, 3567, 3584, 3596, 3604, 3631, 3638, 3650, 3862, 3894, 3907, 3919, 3953, 3973, 3990, 4004, 4023, 4033, 4056, 4067, 4081, 4092, 4100, 4118, 4123, 4135, 4157, 4190, 4197, 4203, 4210, 4274, 4292, 4294, 4325, 4362, 4364, 4540, 4542, 4557, 4571, 4617], 'SR': [35, 58, 75, 138, 160, 271, 324, 347, 364, 427, 449, 560, 1909, 2013, 2057, 2105, 2124, 2133, 2142, 2174, 2258, 2271, 2315, 2375, 2449, 2612, 2664, 2747, 2765, 3199, 3211, 3400, 3571, 3587, 3633, 3955, 3976, 4025, 4069, 4101, 4125, 4213, 4277, 4544, 4573], 'proteins': [36, 59, 76, 325, 348, 365, 703, 714, 1460, 1994, 2014, 2051, 2058, 2106, 2143, 2259, 2272, 2316, 2450, 2495, 2613, 2665, 3447, 3572, 3634, 3977, 4026, 4070, 4126, 4214, 4545], 'have': [37, 326, 1274, 1441, 1958, 2024, 2381], 'only': [38, 327, 770, 2619], 'been': [39, 328, 1442, 1959, 2264, 2382], 'investigated': [40, 329], 'on': [41, 80, 279, 330, 369, 568, 716, 2128, 2260, 2269, 2451, 2666, 3476, 3601, 3611, 3635, 3890, 3915, 4027, 4104, 4153, 4437, 4478], 'limited': [43, 332, 1404, 4418], 'number': [44, 333, 2928], 'HIV-1': [46, 52, 64, 86, 100, 120, 335, 341, 353, 375, 389, 409, 587, 713, 774, 889, 952, 1277, 1625, 1771, 1859, 2389, 2466, 2671, 2688, 2756, 2922, 3027, 3053, 4349, 4378, 4610], 'splicing': [47, 65, 82, 92, 287, 336, 354, 371, 381, 576, 694, 2019, 2110, 2457, 2462, 2672, 2693, 2758, 2774, 3143, 3301, 3365, 3470, 3522, 3568, 3637, 3676, 3679, 3835, 3852, 3928, 4031, 4043, 4105], 'by': [49, 105, 159, 225, 237, 246, 338, 394, 448, 514, 526, 535, 1292, 1405, 1452, 2111, 2165, 2183, 2266, 2317, 2387, 2900, 3204, 3258, 3264, 3272, 3287, 3450, 3453, 3474, 3486, 3570, 3575, 3589, 3975, 4212, 4242, 4321, 4329, 4435, 4473, 4553, 4625], 'using': [50, 339, 634, 3359, 3496, 3530, 4342, 4464, 4561], 'small': [51, 340, 602, 623], 'RNA': [53, 87, 281, 342, 376, 570, 642, 1918, 1967, 1999, 2075, 2207, 2332, 2689, 2757, 2959, 3029, 3055, 3117, 3292, 3336, 3430, 3515, 3641, 3841, 4036, 4299, 4326, 4351, 4380, 4401, 4593], 'pieces.': [54, 343], 'To': [55, 344, 1950, 2890], 'understand': [56, 345], 'how': [57, 346], 'influence': [60, 349], 'use': [62, 351], 'sites,': [66, 355, 809], 'we': [67, 223, 356, 512, 2677], 'tested': [68, 137, 357, 426], 'overproduction': [72, 361], 'individual': [74, 270, 363, 559, 2663, 3632, 4024, 4543], 'HeLa': [78, 367, 2679, 3306, 4305, 4479], 'cells': [79, 368, 1870, 2680, 4234, 4306, 4480], 'pattern': [83, 372], 'an': [85, 280, 374, 569, 667, 1354, 1717, 2600, 3045, 3064, 3133, 3540], 'that': [88, 229, 274, 377, 518, 563, 653, 1276, 1444, 1783, 2190, 2684, 2737, 2780, 3590, 3682, 4012], 'contained': [89, 378, 2781], 'all': [90, 379, 655, 2691], 'sites.': [93, 288, 382, 577, 2796], 'steady': [95, 183, 384, 472], 'state': [96, 184, 385, 473], 'levels': [97, 386], 'mRNAs': [101, 390, 697, 711, 870, 1642, 1696, 1757, 1846, 1899], 'produced': [102, 391], 'were': [103, 123, 151, 392, 412, 440, 2483, 2760, 2776, 2816, 2898, 2931, 3192, 3202, 3256, 3275, 3303, 3416, 3472, 3484, 3489, 3526, 3683, 3842, 3854, 3960, 3994, 4008, 4051, 4240, 4327, 4433, 4462, 4471], 'quantified': [104, 393, 4463], 'reverse': [106, 395, 599, 620, 4386], 'transcriptase-PCR.': [107, 396], 'For': [108, 397, 2655, 2767, 3399, 3517], 'interpretation': [109, 398, 2768], 'data,': [112, 401, 2771], 'transcripts': [113, 402, 652, 660, 691, 1726, 2321, 2779], 'containing': [114, 282, 403, 571, 2007, 2690, 2920, 3025, 3063, 3654, 4376], 'one': [115, 134, 404, 423, 773, 1996, 2122, 2739, 2787, 4082], 'or': [116, 130, 405, 419, 677, 1457, 1686, 1997, 2182, 2788, 3190, 3219, 3290, 3344, 3404, 3412, 3478, 3644, 3885, 3950, 3982, 4064, 4074, 4083, 4120, 4128, 4583], 'several': [117, 406, 1622, 2789], 'spliced': [124, 413, 3510, 3874, 4110], 'vitro': [126, 415, 2487, 2602, 2773, 3300, 3364, 3834, 4030, 4042], 'presence': [129, 418, 958, 3296, 3583, 4066, 4080, 4091, 4117], 'absence': [132, 421, 3594, 4061], 'proteins.': [139, 161, 428, 450, 632, 1763, 2748, 3200, 4278], 'Both': [140, 429], 'vivo': [142, 203, 278, 431, 492, 567, 2752], 'vitro,': [145, 434], 'A2': [148, 166, 437, 455, 1840], 'A3': [150, 439, 1634, 2627, 3663, 3877, 3932, 4175], 'found': [152, 251, 441, 540, 771], 'be': [154, 253, 443, 542, 799, 2138, 2475], 'strongly': [155, 163, 195, 235, 444, 452, 484, 524], 'specifically': [157, 187, 446, 476, 2121], 'regulated': [158, 447, 1894], 'ASF/SF2': [162, 178, 247, 451, 467, 536, 2496], 'activates': [164, 453], 'site': [165, 172, 197, 454, 461, 486, 767, 812, 818, 822, 826, 1361, 1690, 1839, 2152, 2200, 2501, 2626, 2785, 3041, 3067, 3216, 3657, 3931], 'lesser': [170, 459], 'extent': [171, 460], 'A1.': [173, 462], 'As': [174, 463], 'result,': [176, 465], 'upon': [177, 466, 896, 956, 1902], 'overexpression,': [179, 468], 'vpr': [181, 470], 'mRNA': [182, 471], 'level': [185, 474, 4539], 'increased.': [188, 477], 'SC35': [189, 478, 2378, 2498, 2621, 4127], 'SRp40,': [191, 241, 480, 530, 2615, 2743], 'but': [192, 481, 2280], 'not': [193, 482, 1344, 4014], '9G8,': [194, 483, 2380, 3409, 4071], 'activate': [196, 485, 2273, 2625], 'A3,': [198, 487, 745, 1448, 3939], 'their': [200, 489, 897, 1406, 2035, 2284], 'overexpression': [201, 238, 490, 527, 3195], 'ex': [202, 277, 491, 566, 2751], 'induces': [204, 493, 1864], 'dramatic': [206, 495], 'accumulation': [207, 496], 'tat': [210, 499], 'mRNA,': [211, 500], 'detriment': [214, 503], 'most': [216, 505], 'other': [219, 508, 690, 1352], 'viral': [220, 509, 2261], 'Here': [222, 511], 'showed': [224, 513, 2608], 'Western': [226, 515, 3457, 4554], 'blot': [227, 516, 3458, 4555], 'analysis': [228, 517, 4556], 'Nef': [231, 520, 1760, 1764, 4611], 'protein': [232, 272, 521, 561, 687, 1700, 1715, 1910, 2040, 2125, 2175, 2189, 2620, 3141, 3212, 3401, 3415, 3588, 3956, 4102, 4574, 4612], 'synthesis': [233, 522], 'decreased': [236, 525], 'SC35,': [240, 529, 2614, 2742, 3411, 4073, 4582], 'ASF/SF2.': [243, 532], 'Finally,': [244, 533, 1838], 'activation': [245, 534, 3144, 3569, 3605, 3627, 3974, 3991, 4005, 4211], '9G8': [249, 538, 2746, 3142, 4584], 'was': [250, 539, 769, 3014, 3093, 3128, 3154, 3392, 3448, 3504, 3573, 3616, 4109, 4282, 4300, 4319, 4368, 4417, 4450, 4551, 4621], 'independent': [254, 543], 'RS': [257, 546, 2170, 2178, 4569], 'domain.': [258, 547], 'This': [259, 548, 1713, 2308, 2800, 4407], 'first': [262, 551, 3866], 'investigation': [263, 552], 'variations': [268, 557, 2366], 'concentrations': [273, 562, 2370], 'performed': [276, 565, 2484, 2604, 2777, 2932, 3304, 3490, 4052], 'complex': [284, 573, 2064], 'set': [285, 574, 2669], 'plays': [579, 1716], 'key': [581], 'role': [582, 1719, 1797, 2256], 'production': [584, 683, 1640, 1755, 1844, 2275, 2808, 3131, 3281], '1The': [588], 'abbreviations': [589, 610], 'are:': [591, 612], 'HIV-1,': [592, 613], '1;': [597, 618], 'RT,': [598, 619], 'transcriptase;': [600, 621], 'sn,': [601, 622], 'nuclear;': [603, 624], 'hnRNP,': [604, 625], 'heterogeneous': [605, 626], 'nuclear': [606, 627, 1855, 3308, 3349, 4038, 4057, 4093, 4113], 'ribonucleoprotein;': [607, 628], 'nt,': [608, 629], 'nucleotide.1The': [609], 'nucleotide.': [630], 'retroviral': [631], 'By': [633], 'integrated': [636], 'proviral': [637], 'genome': [638], 'as': [639, 672, 678, 1282, 1358, 2477, 2933, 3223, 3277, 3323, 3419, 3506, 3548, 3620, 3669, 3845, 3856, 3962, 4248, 4357], 'template,': [641], 'polymerase': [643, 3293], 'II': [644], 'infected': [647, 1781], 'cell': [648, 1782, 1865, 2385, 3307, 4559], 'produces': [649, 2685], 'long': [650], 'primary': [651, 1725], 'identical.': [656], 'Some': [657], 'these': [659, 860, 1616, 2750, 3446], 'transported': [662], 'cytoplasm': [665, 1729], 'intact': [668, 1724], 'form': [669], 'serve': [671], 'genomes': [673], 'new': [675], 'virions': [676], 'messenger': [679], 'RNAs': [680, 3286, 4141], 'Gag-Pol': [686], 'precursor.': [688], 'undergo': [692], 'alternative': [693, 718, 2109], 'auxiliary': [700], 'regulatory': [702, 1714, 2117, 3680], 'Env': [706], 'precursor': [707, 3864, 4140], 'protein.': [708, 1850, 2766], 'Production': [709], 'encoding': [712, 2957], 'depends': [715, 1901], 'utilization': [719, 1620], 'four': [721, 2461], '5′-splice': [722], 'D1': [724, 2783, 3658], 'D4': [726, 813, 4392], '(1Purcell': [727, 752, 829, 871, 1701], 'D.F.': [728, 753, 830, 872, 1651, 1702], 'Martin': [729, 754, 831, 873, 1652, 1703], 'M.A.': [730, 755, 832, 874, 1653, 1704], 'J.': [731, 756, 784, 833, 849, 875, 966, 1071, 1097, 1113, 1130, 1144, 1176, 1177, 1195, 1197, 1199, 1209, 1230, 1235, 1258, 1261, 1313, 1365, 1366, 1473, 1499, 1518, 1554, 1556, 1558, 1568, 1601, 1604, 1654, 1668, 1669, 1705, 1933, 2221, 2298, 2329, 2506, 2507, 2519, 2540, 2545, 2636, 2639, 2701, 2831, 2912, 2998, 3116, 3169, 3233, 3333, 3429, 3754, 3779, 3813, 3816, 4497, 4592], 'Virol.': [732, 757, 785, 834, 850, 876, 967, 1098, 1114, 1236, 1314, 1500, 1655, 1706, 1881, 2299, 2546, 2702, 2913], '1993;': [733, 758, 835, 877, 1656, 1707], '67:': [734, 759, 836, 878, 1657, 1708], '6365-6378Crossref': [735, 760, 837, 879, 1658, 1709], 'PubMed': [736, 761, 789, 838, 854, 880, 915, 971, 984, 1003, 1020, 1037, 1054, 1082, 1102, 1118, 1134, 1148, 1168, 1183, 1203, 1224, 1240, 1267, 1304, 1318, 1333, 1377, 1395, 1432, 1484, 1504, 1522, 1542, 1562, 1583, 1610, 1659, 1675, 1710, 1745, 1818, 1833, 1885, 1924, 1945, 1973, 1988, 2081, 2098, 2213, 2233, 2250, 2303, 2360, 2403, 2437, 2513, 2534, 2550, 2573, 2594, 2650, 2706, 2729, 2842, 2860, 2885, 2917, 2949, 3009, 3088, 3123, 3180, 3240, 3380, 3436, 3703, 3720, 3737, 3765, 3783, 3803, 3827, 4261, 4508, 4533, 4599], 'Google': [737, 762, 790, 839, 855, 881, 918, 972, 987, 1006, 1023, 1040, 1057, 1085, 1105, 1119, 1137, 1151, 1171, 1186, 1206, 1227, 1243, 1270, 1307, 1319, 1336, 1380, 1398, 1435, 1487, 1507, 1525, 1545, 1565, 1586, 1613, 1660, 1678, 1711, 1748, 1821, 1836, 1888, 1927, 1948, 1976, 1991, 2084, 2101, 2216, 2236, 2253, 2306, 2338, 2363, 2406, 2440, 2516, 2537, 2553, 2576, 2597, 2653, 2707, 2732, 2845, 2863, 2888, 2918, 2952, 3012, 3091, 3126, 3183, 3243, 3342, 3383, 3439, 3706, 3723, 3740, 3768, 3786, 3806, 3830, 4264, 4511, 4536, 4602], 'Scholar)': [738, 2339, 2919, 3013, 3092, 3127], '3′-splice': [741, 766, 2199], '(A1,': [743], 'A2,': [744, 1447], 'A4a,': [746, 1684, 3881, 3940], '-b,': [747, 1685], '-c,': [748], 'A5,': [749], 'A7)': [751], 'Scholar).': [763, 791, 856, 882, 1271, 1337, 1399, 1436, 1614, 1679, 1712, 1749, 1837, 1889, 1949, 1992, 2102, 2254, 2307, 2364, 2654, 2889, 2953, 3184, 3244, 3384, 3440, 3831, 4537, 4603], 'An': [764], 'additional': [765, 1777], '(A6)': [768], 'strain': [775], '(2Benko': [776], 'D.M.': [777, 842], 'Schwartz': [778, 843], 'S.': [779, 844, 1060, 1193, 1250, 1413, 1462, 1552, 1593, 1739, 2349, 2568, 2710, 2820, 2866, 3158, 3743, 4486, 4514], 'Pavlakis': [780, 845], 'G.N.': [781, 846], 'Felber': [782, 847], 'B.K.': [783, 848], '1990;': [786, 851], '64:': [787, 852], '2505-2518Crossref': [788, 853], 'Donor': [792], 'D1,': [794], 'D2,': [795], 'D3': [797], 'can': [798, 2107, 2474], 'coupled': [800, 816], 'any': [802], 'A1': [805, 1456, 2188, 2792], 'A5': [807, 1751, 2794, 3886, 3943, 4177], 'whereas': [810], 'donor': [811, 890, 2463, 2784, 3656], 'exclusively': [815], 'A7': [819, 1450, 1636, 1691, 2502, 4394], 'A6': [823], 'when': [824], 'this': [825, 1956, 2132, 2472], 'present': [828, 2469], 'Scholar,': [840, 919, 973, 988, 1007, 1024, 1041, 1058, 1086, 1106, 1120, 1138, 1152, 1172, 1187, 1207, 1228, 1244, 1308, 1320, 1381, 1488, 1508, 1526, 1546, 1566, 1587, 2217, 2237, 2407, 2517, 2538, 2554, 2577, 2708, 2846, 2864, 3707, 3724, 3741, 3769, 3787, 3807, 4512], '2Benko': [841], 'combination': [858], 'various': [861, 3675, 3871], 'gives': [863], 'rise': [864], 'at': [866, 2499, 3389, 3875, 3930, 4173], 'least': [867], '35': [868], 'different': [869, 2135, 2755, 2763, 4548], 'Although': [883, 2365], 'relative': [885], 'efficiencies': [886, 950, 3929, 3959], 'seem': [892, 2022], 'depend': [894, 955], 'mainly': [895], 'complementarity': [898], 'U1': [901, 2042], 'snRNA': [902], '5′-terminal': [903], 'sequence': [904, 3030, 4381], "(3O'Reilly": [905, 1294], 'M.M.': [906, 1295], 'McNally': [907, 1296], 'M.T.': [908, 1297], 'Beemon': [909, 1298], 'K.L.': [910, 1299], 'Virology.': [911, 1300], '1995;': [912, 981, 1017, 1301, 1369, 2335, 3339, 3717], '213:': [913, 1302], '373-385Crossref': [914, 1303], 'Scopus': [916, 985, 1004, 1021, 1038, 1055, 1083, 1103, 1135, 1149, 1169, 1184, 1204, 1225, 1241, 1268, 1305, 1334, 1378, 1396, 1433, 1485, 1505, 1523, 1543, 1563, 1584, 1611, 1676, 1746, 1819, 1834, 1886, 1925, 1946, 1974, 1989, 2082, 2099, 2214, 2234, 2251, 2304, 2361, 2404, 2438, 2514, 2535, 2551, 2574, 2595, 2651, 2730, 2843, 2861, 2886, 2950, 3010, 3089, 3124, 3181, 3241, 3381, 3437, 3704, 3721, 3738, 3766, 3784, 3804, 3828, 4262, 4509, 4534, 4600], '(101)': [917, 1306], '4,': [920], 'Damier,': [921], 'L.': [922, 1066, 1383, 1385, 1419, 1468, 2716, 2826, 2848, 2850, 2872, 2937, 2939, 2967, 2987, 3076, 3078, 3114, 3164, 3368, 3370, 3427, 3749, 4492, 4520, 4590], '(1997)': [923], 'Etude': [924], 'de': [925, 928, 935, 938], 'la': [926], 'Régulation': [927], "l'Épissage": [929], 'du': [930, 933], 'Transcrit': [931], 'Primaire': [932], 'Virus': [934, 2398], "l'Immunodéficience": [936], 'Humaine': [937], 'Type': [939], '1,': [940], 'HIV-1.': [941], 'Ph.D.': [942], 'thesis,': [943], 'Université': [944], 'Henri': [945], 'Poincaré,': [946], 'Nancy,': [947], 'FranceGoogle': [948], 'Scholar),': [949, 2441, 2733, 3343, 4265], 'cis-regulatory': [960, 2114], 'elements': [961, 1440, 2118, 3681], '(5Staffa': [962], 'A.': [963, 965, 975, 977, 1062, 1092, 1124, 1211, 1234, 1248, 1254, 1310, 1312, 1421, 1464, 1494, 1512, 1570, 1591, 1597, 1878, 2345, 2409, 2419, 2521, 2544, 2558, 2569, 2579, 2718, 2822, 2874, 3160, 3745, 3773, 4183, 4488, 4522, 4618], 'Cochrane': [964, 976, 1233, 1311, 2543], '1994;': [968, 1000, 1315, 3700], '68:': [969, 1316], '3071-3079Crossref': [970, 1317], '6Staffa': [974], 'Mol.': [978, 997, 1014, 1048, 1162, 1178, 1214, 1262, 1536, 1573, 1605, 1670, 2508, 2524, 2588, 3234, 3697, 3714, 3797, 4255], 'Cell.': [979, 998, 1015, 1049, 1163, 1215, 1537, 1574, 2525, 2589, 3235, 3698, 3715, 3798, 4256], 'Biol.': [980, 999, 1016, 1050, 1072, 1164, 1179, 1263, 1367, 1474, 1538, 1606, 1671, 1809, 2094, 2246, 2509, 2590, 2640, 2832, 3170, 3236, 3699, 3716, 3755, 3799, 3817, 4257, 4498], '15:': [982, 1018, 3718], '4597-4605Crossref': [983], '(152)': [986], '7Amendt': [989], 'B.A.': [990, 1009, 1028, 1324, 3690, 3709, 3728], 'Hesslein': [991, 3691], 'D.': [992, 1045, 1252, 1415, 1595, 2712, 2868, 3692, 4516], 'Chang': [993, 2999, 3693], 'L.J.': [994, 3694], 'Stoltzfus': [995, 1012, 1029, 1046, 1067, 1095, 1111, 1325, 1422, 1469, 1497, 2699, 2719, 2827, 2875, 3165, 3695, 3712, 3729, 3750, 4493, 4523], 'C.M.': [996, 1013, 1030, 1047, 1068, 1096, 1112, 1326, 1423, 1470, 1498, 2700, 2720, 2828, 2876, 3166, 3696, 3713, 3730, 3751, 4494, 4524], '14:': [1001, 3701], '3960-3970Crossref': [1002, 3702], '(125)': [1005, 3705], '8Amendt': [1008, 3708], 'Si': [1010, 3710], 'Z.H.': [1011, 1043, 3711], '4606-4615Crossref': [1019, 3719], '(123)': [1022, 3722], '9Si': [1025, 1321, 3725], 'Z.': [1026, 1322, 3726], 'Amendt': [1027, 1323, 3727], 'Nucleic': [1031, 1327, 1426, 2723, 2879, 3731, 4527], 'Acids': [1032, 1328, 1427, 2724, 2880, 3732, 4528], 'Res.': [1033, 1329, 1390, 1428, 1828, 2399, 2431, 2725, 2855, 2881, 2944, 3083, 3375, 3733, 4529], '1997;': [1034, 1330, 1392, 2857, 2946, 3085, 3377, 3734], '25:': [1035, 1331, 1938, 2226, 3735], '861-867Crossref': [1036, 1332, 3736], '(86)': [1039, 1335, 3739], '10Si': [1042], 'Rauch': [1044], '1998;': [1051, 2357, 2400], '18:': [1052, 1132, 1520, 3781], '5404-5413Crossref': [1053], '(68)': [1056], '11Jacquenet': [1059, 3742], 'Mereau': [1061, 1247, 1463, 1590, 2821, 3159, 3744, 4487], 'Bilodeau': [1063, 1416, 1465, 2713, 2823, 2869, 3161, 3746, 4489, 4517], 'P.S.': [1064, 1088, 1108, 1417, 1466, 1490, 2696, 2714, 2824, 2870, 3162, 3747, 4490, 4518], 'Damier': [1065, 1418, 1467, 2715, 2825, 2871, 3163, 3748, 4491, 4519], 'Branlant': [1069, 1259, 1386, 1424, 1471, 1602, 2721, 2829, 2851, 2877, 2940, 3079, 3167, 3371, 3752, 4495, 4525], 'C.': [1070, 1260, 1387, 1425, 1472, 1603, 2351, 2353, 2393, 2425, 2722, 2830, 2852, 2878, 2941, 3080, 3168, 3372, 3753, 4252, 4496, 4526], 'Chem.': [1073, 1368, 1475, 2641, 2833, 3171, 3756, 3818, 4499], '2001;': [1074, 1099, 1180, 1200, 1216, 1429, 1476, 1501, 1559, 1575, 1742, 2095, 2247, 2510, 2526, 2726, 2834, 2882, 3172, 3757, 4500, 4530], '276:': [1075, 1477, 2835, 3173, 3758, 4501], '40464-40475Abstract': [1076, 1478, 2836, 3174, 3759, 4502], 'Full': [1077, 1079, 1219, 1221, 1372, 1374, 1479, 1481, 1578, 1580, 1813, 1815, 1940, 1942, 2228, 2230, 2529, 2531, 2645, 2647, 2837, 2839, 3175, 3177, 3760, 3762, 3822, 3824, 4503, 4505], 'Text': [1078, 1080, 1220, 1222, 1373, 1375, 1480, 1482, 1579, 1581, 1814, 1816, 1941, 1943, 2229, 2231, 2530, 2532, 2646, 2648, 2838, 2840, 3176, 3178, 3761, 3763, 3823, 3825, 4504, 4506], 'PDF': [1081, 1223, 1376, 1483, 1582, 1817, 1944, 2232, 2533, 2649, 2841, 3179, 3764, 3826, 4507], '(110)': [1084, 1486, 2844, 3182, 3767, 4510], '12Bilodeau': [1087, 1489], 'Domsic': [1089, 1109, 1491, 2697], 'J.K.': [1090, 1110, 1492, 2698], 'Mayeda': [1091, 1123, 1210, 1493, 1511, 1569, 2520, 2557, 3772], 'Krainer': [1093, 1125, 1212, 1495, 1513, 1571, 2089, 2241, 2522, 2561, 2586, 3774], 'A.R.': [1094, 1126, 1213, 1496, 1514, 1572, 2090, 2242, 2523, 2562, 2587, 3775], '75:': [1100, 1502], '8487-8497Crossref': [1101, 1503], '(99)': [1104, 1506], '13Bilodeau': [1107], '1999;': [1115, 1131, 1165, 1519, 1539, 1672, 1810, 1882, 2591, 2703, 3120, 3237, 3433, 3780, 3800, 4596], '73:': [1116, 2704], '9764-9772Crossref': [1117, 2705], '14Caputi': [1121, 1509, 3770], 'M.': [1122, 1140, 1157, 1510, 1531, 1807, 1876, 2295, 2323, 2413, 2421, 2427, 2638, 2909, 3229, 3327, 3771, 3792, 3815, 4619], 'Zahler': [1127, 1141, 1515, 3776], 'A.M.': [1128, 1142, 1516, 2632, 3777, 3809], 'EMBO': [1129, 1143, 1198, 1517, 1557, 3778], '4060-4067Crossref': [1133, 1521, 3782], '(225)': [1136, 1524, 3785], '15Caputi': [1139], '2002;': [1145, 1237, 1264, 1607, 2547], '21:': [1146], '845-855Crossref': [1147], '(103)': [1150], '16Del': [1153, 1527, 3788], 'Gatto-Konczak': [1154, 1528, 3789], 'F.': [1155, 1529, 2391, 2911, 3004, 3790], 'Olive': [1156, 1530, 3791], 'Gesnel': [1158, 1532, 3793], 'M.C.': [1159, 1533, 3794], 'Breathnach': [1160, 1534, 3795], 'R.': [1161, 1256, 1535, 1599, 1982, 2331, 2971, 3335, 3796], '19:': [1166, 1540, 2592, 3238, 3801], '251-260Crossref': [1167, 1541, 3802], '(198)': [1170, 1544, 2575, 3805], '17Tange': [1173], 'T.O.': [1174, 1189, 1548, 2504], 'Kjems': [1175, 1196, 1364, 1555, 2505, 2635, 3812], '312:': [1181, 2511], '649-662Crossref': [1182, 2512], '(50)': [1185, 2515], '18Tange': [1188, 1547], 'Damgaard': [1190, 1549, 2633, 3810], 'C.K.': [1191, 1550, 2634, 3811], 'Guth': [1192, 1551], 'Valcarcel': [1194, 1553, 1932, 2220], '20:': [1201, 1560], '5748-5758Crossref': [1202, 1561], '(133)': [1205, 1564], '19Zhu': [1208, 1567, 2518], '8:': [1217, 1576, 2527], '1351-1361Abstract': [1218, 1577, 2528], '(291)': [1226, 1585, 2536], '20Pongoski': [1229, 2539], 'Asai': [1231, 2541], 'K.': [1232, 1735, 2327, 2423, 2542, 2985, 3331], '76:': [1238, 2548], '5108-5120Crossref': [1239, 2549], '(35)': [1242, 1820, 2552], '21Marchand': [1245, 1588], 'V.': [1246, 1589], 'Jacquenet': [1249, 1592], 'Thomas': [1251, 1594], 'Mougin': [1253, 1420, 1596, 2717, 2873, 4521], 'Gattoni': [1255, 1598, 2330, 3334], 'Stevenin': [1257, 1600, 2328, 3115, 3232, 3332, 3428, 4591], '323:': [1265, 1608], '629-652Crossref': [1266, 1609], '(83)': [1269, 1612], 'Several': [1272, 1438], 'studies': [1273, 2268], 'shown': [1275, 3547, 3670, 3998, 4152, 4181, 4219], 'suboptimal': [1281], 'follows.': [1283], '(i)': [1284, 2479, 3019], 'Their': [1285, 1339, 1401], 'polypyrimidine': [1286, 2162], 'tracts': [1287], 'short': [1289], 'interrupted': [1291], 'purines': [1293], '5Staffa': [1309], '(ii)': [1338, 2599, 3044], 'branch': [1340, 1360], 'point': [1341], 'sequences': [1342, 2146], 'canonical,': [1345], 'some': [1348, 2372], 'cases,': [1349], 'residue': [1351], 'than': [1353], 'adenosine': [1355], '(22Dyhr-Mikkelsen': [1362], 'H.': [1363, 4254], '270:': [1370], '24060-24066Abstract': [1371], '(55)': [1379, 1835], '23Damier': [1382, 2847], 'Domenjoud': [1384, 2849, 2938, 3077, 3369], 'Biochem.': [1388, 1826, 1935, 2223, 2853, 2942, 3081, 3373], 'Biophys.': [1389, 1827, 2854, 2943, 3082, 3374], 'Commun.': [1391, 1829, 2856, 2945, 3084, 3376], '237:': [1393, 2858, 2947, 3086, 3378], '182-187Crossref': [1394, 2859, 2948, 3087, 3379], '(22)': [1397, 2862, 2951, 3090, 3382], '(iii)': [1400], 'accessibility': [1402], 'sequestering': [1407], 'stable': [1409], 'secondary': [1410], 'structures': [1411], '(24Jacquenet': [1412], 'Ropers': [1414, 2711, 2867, 4515], '29:': [1430, 2727, 2883, 4531], '464-478Crossref': [1431, 2728, 2884, 4532], '(66)': [1434, 2731, 2887, 4535], '(iv)': [1437], 'cis-inhibitory': [1439], 'identified': [1443, 1960, 3685, 4472], 'down-regulate': [1445], 'binding': [1453, 1904, 2112, 2159], 'hnRNP': [1455, 1458, 2187], 'H': [1459], '(11Jacquenet': [1461, 2819, 3157, 4485], 'Despite': [1615], 'numerous': [1617, 2008], 'handicaps,': [1618], 'essential': [1629, 1718, 2060], 'virus': [1631, 1785, 2388], 'multiplication.': [1632, 1786], 'Sites': [1633], 'Tat': [1645], 'transcriptional': [1646], 'activator': [1647], '(see': [1648], 'Ref.': [1649, 1666, 1733, 1874], '1Purcell': [1650], 'Scholar': [1661, 1822, 1928, 1977, 2085], 'review': [1664, 1731, 1872], 'see': [1665, 1732, 1804, 1873, 1914, 1963, 2071, 2203], '25Karn': [1667], '293:': [1673], '235-254Crossref': [1674], '(388)': [1677], 'One': [1680], 'three': [1683, 3528], '-c': [1687], 'Rev': [1699], 'transport': [1722], '(for': [1730, 1802, 1871, 1912, 1961, 2069, 2201], '26Boris-Lawrie': [1734], 'Roberts': [1736], 'T.M.': [1737], 'Hull': [1738], 'Life': [1740], 'Sci.': [1741, 1936, 2224, 2566], '69:': [1743], '2697-2709Crossref': [1744], '(30)': [1747], 'Site': [1750], 'required': [1753, 2287], 'Vpu': [1762], 'down-regulates': [1765], 'cell-surface': [1767], 'expression': [1768, 3221, 4541], 'receptor': [1772], 'glycoprotein': [1773], 'has': [1775, 2263], 'many': [1776], 'roles': [1778], 'favor': [1784], 'It': [1787], 'also': [1789, 3687], 'responsible': [1790], 'AIDS': [1792, 2430], 'pathology,': [1793], 'because': [1794], 'its': [1796, 3593], 'bystander': [1799], 'lymphocyte': [1800], 'apoptosis': [1801], 'reviews': [1803, 1913, 1962, 2070, 2202], 'Refs.': [1805, 1915, 1964, 2072, 2204], '27Harris': [1806], 'Curr.': [1808, 2091, 2243], '9:': [1811, 1883], 'R459-R461Abstract': [1812], '28Azad': [1824], 'A.A.': [1825], '2000;': [1830, 1921, 1937, 1970, 2078, 2210, 2225, 2300, 2434], '267:': [1831], '677-685Crossref': [1832], 'needed': [1842], 'Vpr': [1849, 1851], 'implicated': [1853], 'import': [1856], 'pre-integration': [1860], 'complex,': [1861], 'it': [1863, 4318], 'cycle': [1866], 'arrest': [1867], 'proliferating': [1869], '29Bukrinsky': [1875], 'Adzhubei': [1877], 'Rev.': [1879], 'Med.': [1880], '39-49Crossref': [1884], '(78)': [1887], 'efficiency': [1891, 2156, 3503, 4032], 'cellular': [1898, 2369, 2675, 4298], 'generally': [1900, 2119, 2153], 'members': [1906, 1954], 'family': [1911, 1957, 4575], '30Graveley': [1916, 1965, 2073, 2205], 'B.R.': [1917, 1966, 2074, 2206], '(N.': [1919, 1968, 2076, 2208, 2333, 3118, 3337, 3431, 4594], 'Y.).': [1920, 1969, 2077, 2209, 2334, 3119, 3338, 3432, 4595], '6:': [1922, 1971, 2079, 2211], '1197-1211Crossref': [1923, 1972, 2080, 2212], '(878)': [1926, 1975, 2083, 2215], '31Smith': [1930, 2218], 'C.W.': [1931, 2219], 'Trends': [1934, 2222], '381-388Abstract': [1939, 2227], '(752)': [1947, 2235], 'date,': [1951], '10': [1952], 'distinct': [1953], '32Manley': [1979], 'J.L.': [1980], 'Tacke': [1981], 'Genes': [1983], 'Dev.': [1984], '1996;': [1985], '10:': [1986], '1569-1579Crossref': [1987], '(601)': [1990], 'These': [1993, 2116, 3958], 'contain': [1995], 'two': [1998, 2895], 'recognition': [2000], 'motif(s),': [2001], 'together': [2002], 'with': [2003, 2037, 2176, 2605, 2681, 2762, 2778, 3016, 3491, 3539, 3837, 3949, 4045, 4266, 4311, 4370, 4482], 'carboxyl-terminal': [2005], 'domain': [2006, 2171, 2179, 4570], 'arginine-serine': [2009], 'amino': [2010], 'acid': [2011], 'pairs.': [2012], 'involved': [2016], 'constitutive': [2018], 'where': [2020], 'they': [2021], 'redundant': [2025], 'functions': [2026], 'assistance': [2028], 'spliceosomal': [2030, 2195], 'component': [2031], 'assembly.': [2032], 'Because': [2033], 'interactions': [2036], '70K': [2039], 'snRNP,': [2043], '35-kDa': [2045], 'subunit': [2046], 'factor': [2048, 3566, 3972], 'U2AF,': [2049], 'U4/U6.U5': [2054], 'tri-snRNP,': [2055], 'actors': [2061], 'mechanism': [2065], 'spliceosome': [2067], 'assembly': [2068], '33Hastings': [2087, 2239], 'M.L.': [2088, 2240, 2992], 'Opin.': [2092, 2244], 'Cell': [2093, 2245, 3313], '13:': [2096, 2248], '302-309Crossref': [2097, 2249], '(386)': [2100, 2252], 'In': [2103, 2749, 3245, 3299], 'addition,': [2104], 'regulate': [2108], 'elements.': [2115], 'bind': [2120], 'given': [2123, 3538], 'and,': [2126], 'depending': [2127], 'identity': [2130], 'protein,': [2134], 'may': [2137], 'generated.': [2139], 'Binding': [2140], 'specific': [2145, 4577], 'located': [2147], 'downstream': [2148], 'from': [2149, 2311, 2961, 3031, 3056, 3996, 4010, 4302, 4352, 4382, 4402], 'reinforces': [2154], 'U2AF': [2158], 'tract,': [2163], 'either': [2164], 'direct': [2166], 'interaction': [2167], 'U2AF35': [2181], 'displacement': [2184], 'blocks': [2191], 'access': [2193], 'components': [2196], 'multiplication': [2262], 'demonstrated': [2265, 2491], 'previous': [2267, 4476], 'adenovirus.': [2270], 'early': [2278], 'mRNAs,': [2279], 'limitation': [2282, 2309], 'activity': [2285], 'late': [2290, 2320], 'phase': [2291], 'infection': [2293, 2386], '(34Molin': [2294], 'Akusjarvi': [2296, 2354], 'G.': [2297, 2355, 2395, 3231], '74:': [2301], '9002-9009Crossref': [2302], '(31)': [2305], 'results': [2310], 'titration': [2312], 'major': [2319, 4427], '(35Himmelspach': [2322, 3326], 'Cavaloc': [2324, 3328], 'Y.': [2325, 2411, 3110, 3329, 3423, 4586], 'Chebli': [2326, 3330], '1:': [2336, 3340], '794-806PubMed': [2337, 3341], 'and/or': [2340], 'virus-induced': [2342], 'dephosphorylation': [2343], '(36Kanopka': [2344], 'Muhlemann': [2346], 'O.': [2347], 'Petersen-Mahrt': [2348], 'Estmer': [2350], 'Ohrmalm': [2352], 'Nature.': [2356, 3005], '393:': [2358], '185-187Crossref': [2359], '(166)': [2362], 'proteins,': [2376], 'namely': [2377], 'observed': [2383, 4215], 'after': [2384, 4309, 4456], '(37Maldarelli': [2390], 'Xiang': [2392], 'Chamoun': [2394], 'Zeichner': [2396], 'S.L.': [2397], '53:': [2401], '39-51Crossref': [2402], '(29)': [2405], '38Ryo': [2408], 'Suzuki': [2410], 'Arai': [2412], 'Kondoh': [2414], 'N.': [2415, 2429], 'Wakatsuki': [2416], 'T.': [2417, 2560], 'Hada': [2418], 'Shuda': [2420], 'Tanaka': [2422], 'Sato': [2424], 'Yamamoto': [2426, 2428], 'Hum.': [2432], 'Retroviruses.': [2433], '16:': [2435], '995-1005Crossref': [2436], '(38)': [2439], 'little': [2442], 'known': [2444], 'about': [2445], 'action': [2447, 2493], 'between': [2454], 'RNA.': [2467, 4049], 'knowledge': [2470], 'field': [2473], 'summarized': [2476], 'follows:': [2478], 'deep': [2480], 'studies,': [2481], 'which': [2482, 4389], 'both': [2485, 4426], 'vivo,': [2490], '(17Tange': [2503], '39Fu': [2555], 'X.D.': [2556, 2585], 'Maniatis': [2559], 'Proc.': [2563], 'Natl.': [2564], 'Acad.': [2565], 'U.': [2567], '1992;': [2570, 2914], '89:': [2571], '11224-11228Crossref': [2572], '40Mayeda': [2578], 'Screaton': [2580], 'G.R.': [2581], 'Chandler': [2582], 'S.D.': [2583], 'Fu': [2584], '1853-1863Crossref': [2593], '(128)': [2596], 'Scholar);': [2598], 'study': [2603, 2658], 'S100': [2606, 2629, 3320, 3347, 3643, 3934], 'extract': [2607, 2630, 3309, 3321, 3935, 4058, 4094, 4114], 'that,': [2609], 'among': [2610], 'SRp55,': [2616], 'SRp70,': [2618], 'able': [2623], '(41Zahler': [2631], 'Caputi': [2637, 3814], '2004;': [2642, 3819], '279:': [2643, 3820], '10077-10084Abstract': [2644, 3821], '(112)': [2652, 3829], 'complete': [2657, 2924], 'entire': [2668], 'conditions,': [2676], 'cotransfected': [2678, 4241], 'construct': [2683], 'truncated': [2687], '(13Bilodeau': [2695], '24Jacquenet': [2709, 2865, 4513], 'plasmid': [2736, 2893, 2904, 3073, 3108, 3267, 4270, 4483], 'overexpresses': [2738], 'ASF/SF2,': [2744, 3410, 4072, 4581], 'experiments,': [2753], 'very': [2754], 'patterns': [2759], 'obtained': [2761, 3580, 3591], 'overexpressed': [2764], 'assays': [2775, 3302, 3358, 3836, 4044, 4367], 'Plasmids': [2797, 3185], 'Used': [2798], 'Study—pLD-C2,': [2801], 'pLD-C3,': [2802], 'pLD-L3-U1': [2804, 3263], 'constructs,': [2805], 'C2,': [2811, 3462, 3924], 'C3,': [2812, 3463, 4208], 'L3-U1': [2814, 3640, 3652, 3840, 4035, 4048, 4108], 'transcripts,': [2815], 'described': [2817, 2934, 3155, 3224, 3324, 3420, 3857, 4249], 'previously': [2818, 2935, 3156, 3225, 3325, 3421, 3684, 4250], 'build': [2891], 'pLD-C1,': [2894], 'DNA': [2896, 2955, 3902, 4164, 4281, 4293, 4431], 'fragments': [2897, 3909], 'generated': [2899], 'PCR': [2901, 4460], 'amplifications': [2902], 'pBRU3': [2905], '(42Charneau': [2906], 'P.': [2907], 'Alizon': [2908], 'Clavel': [2910], '66:': [2915], '2814-2820Crossref': [2916], 'BRU/LAI': [2923], 'cDNA': [2925, 3208], '(Gen-Bank™': [2926], 'accession': [2927], 'K02013).': [2929], 'Amplifications': [2930], '(23Damier': [2936, 3075, 3367], 'fragment': [2956, 3071, 3098], 'region': [2960], 'position': [2962], '4313': [2963, 3033], '4545': [2965, 3060], '(43Ratner': [2966], 'Haseltine': [2968], 'W.': [2969], 'Patarca': [2970], 'Livak': [2972], 'K.J.': [2973], 'Starcich': [2974], 'B.': [2975], 'Josephs': [2976], 'S.F.': [2977], 'Doran': [2978], 'E.R.': [2979], 'Rafalski': [2980], 'J.A.': [2981, 2994], 'Whitehorn': [2982], 'E.A.': [2983], 'Baumeister': [2984], 'Ivanoff': [2986], 'Petteway': [2988], 'Jr.,': [2989], 'S.R.': [2990], 'Pearson': [2991], 'Lautenberger': [2993], 'Papas': [2995], 'T.S.': [2996], 'Ghrayeb': [2997], 'N.T.': [3000], 'Gallo': [3001], 'R.C.': [3002], 'Wong-Staal': [3003], '1985;': [3006], '313:': [3007], '277-284Crossref': [3008], '(1727)': [3011], 'amplified': [3015, 3101, 4409], 'following:': [3018], 'sense': [3021], 'primer': [3022, 3047, 4387], 'O-756': [3023], '(5′-TATTCTAGATCTCAGGCTGAACATC-3′)': [3024], 'BRU': [3028, 3054], 'positions': [3032, 3057, 4134, 4353, 4383, 4403], '4325': [3035], '(underlined)': [3036, 3061], 'BglII': [3039], 'restriction': [3040, 3066], '(italic);': [3042], 'antisense': [3046], 'O-764': [3048], '(5′-CGGAATTCCTTTCCAGAGGAGCT-3′)': [3049], 'complementary': [3050, 4346, 4398], '4530': [3058], 'EcoRI': [3065], '(italic).': [3068], 'BglII-EcoRI': [3070, 3097], 'pLD-C2': [3074, 3255], 'substituted': [3094], 'DNA.': [3102], 'SP1': [3104], 'ex2': [3105, 3269, 3467], 'inv': [3106, 3270, 3468], '9G8–102': [3107], '(44Cavaloc': [3109, 3422, 4585], 'Bourgeois': [3111, 3424, 4587], 'C.F.': [3112, 3227, 3425, 4588], 'Kister': [3113, 3426, 4589], '5:': [3121, 3434, 4597], '468-483Crossref': [3122, 3435, 4598], '(179)': [3125, 3438, 4601], 'SP6': [3134, 3291], 'transcript': [3135], 'allowing': [3136], 'us': [3137], 'test': [3139, 4624], 'properties': [3145], 'vitro.': [3147], 'Plasmid': [3148], 'ΔPSP': [3149, 4269, 4484], 'transfection': [3152, 4310, 4549], 'experiments': [3153, 4218, 4550], 'pXJ41-ASF,': [3186], 'pXJ41-SRp40,': [3187], 'pXJ42–9G8,': [3188], 'pXJ42-SC35,': [3189], 'pXJ42-SRp20': [3191], 'corresponding': [3198], 'They': [3201, 3274], 'constructed': [3203], 'insertion': [3205], 'each': [3210, 3518, 4363], 'multicloning': [3215], 'pXJ41': [3218], 'pXJ42': [3220], 'vector,': [3222], '(45Bourgeois': [3226], 'Popielarz': [3228], 'Hildwein': [3230], '7347-7356Crossref': [3239], '(61)': [3242], 'Vitro': [3246, 3250], 'Transcription': [3247], 'Assays—Plasmids': [3252], 'pLD-C1': [3253], 'linearized': [3257], 'EcoRI,': [3259], 'plasmids': [3260, 4275], 'pLD-C3': [3261], 'PstI,': [3265], 'Sp1': [3268, 3466], '9G8-102': [3271, 3469], 'HindIII.': [3273], 'templates': [3278], 'capped,': [3283], 'uniformly': [3284, 3838, 4046], 'labeled': [3285, 3839, 4047], 'T7': [3289], '[α-32P]UTP.': [3298], '(from': [3310], 'Computer': [3312], 'Culture': [3314], 'Center': [3315], 'S.A.,': [3316], 'Belgium),': [3317], 'pure': [3318], 'cytoplasmic': [3319], 'prepared': [3322, 3418], 'mixtures': [3345], 'extracts': [3350, 4560], '(4:4': [3351], 'μl': [3352, 4055], '7:1': [3354], 'μl),': [3355], '22-μl': [3357], 'classical': [3360], 'conditions': [3361], 'reaction': [3366], 'duration': [3386], 'incubation': [3388], '30': [3390, 3397, 4420], '°C': [3391], '2': [3394], 'h': [3395, 4308], 'min.': [3398], 'assays,': [3402], '150': [3403, 4119], '300': [3405, 4121], 'ng': [3406, 4122, 4273], 'purified': [3408], 'SRp40': [3413, 4075], 'recombinant': [3414, 3586, 3954], 'used,': [3417], 'degree': [3442], 'purity': [3444], 'verified': [3449], 'electrophoresis': [3451, 3475, 3520, 4436], 'followed': [3452], 'argentic': [3454], 'staining': [3455], 'analysis.': [3459], 'C1,': [3461, 4167], 'L3-U1,': [3464], 'products': [3471, 3511, 3853, 3873, 4145, 4432, 4461], 'analyzed': [3473, 4434], '5': [3477], '6%': [3479, 4439], 'polyacrylamide': [3480, 4440], 'denaturing': [3481], 'gels': [3482], 'visualized': [3485], 'autoradiography.': [3487], 'Quantifications': [3488], 'Phosphor-Imager': [3493], '(Amersham': [3494, 4448, 4466], 'Biosciences)': [3495, 4449], 'ImageQuant': [3498, 3532, 4465], 'software': [3499], '(version': [3500], '5.2).': [3501], 'expressed': [3505], 'ratio': [3508, 3579], '(M)': [3512], 'versus': [3513], 'unspliced': [3514], '(P).': [3516], 'gel': [3519, 4455], 'products,': [3523], 'M/P': [3524, 3544, 3556, 3578, 3612, 4171, 4191], 'values': [3525, 3557, 4172], 'measured': [3527], 'times': [3529], 'software.': [3533], 'mean': [3535], 'value': [3536], 'estimation': [3541], 'measurement': [3545, 4196], 'error,': [3546], 'bar': [3549, 3621], 'errors': [3550, 3600, 3610, 3622, 4189], 'histograms': [3553, 3625, 3925, 3969], 'representing': [3554, 3926], '(Figs.1,': [3558], 'E1–E4,': [3559], '2,': [3560], 'C1–C4,': [3561], '3,': [3563], 'C1–C3).': [3564], 'estimated': [3574, 3599, 3961, 4188, 4552], 'dividing': [3576], '(fold': [3595], 'activation).': [3597], 'factors': [3603, 3989, 4003, 4209], 'due': [3606], 'experimental': [3609], 'measurements': [3613], 'mentioned': [3614], 'above': [3615, 3847], 'deduced': [3617], 'represented': [3619, 3688], 'showing': [3626, 3970, 4169], 'factors.Fig.': [3628], '2Differential': [3629], 'NE/S100': [3645, 3947, 3986], 'mixtures.': [3646], 'A,': [3647, 4040], 'schematic': [3648], 'representation': [3649, 3667], 'pre-mRNA': [3653], 'A5.': [3665], 'Fig.': [3672, 3859, 3964], '1.': [3673, 3860, 3965], '(7Amendt': [3689], '41Zahler': [3808], 'B,': [3832, 4000, 4098, 4132, 4223], 'carried': [3843], 'out': [3844], 'indicated': [3846, 3889, 3914], 'lanes,': [3849], 'fractionated': [3855, 4469], 'Positions': [3861], '(P),': [3865, 4142], 'exon': [3867], '(E),': [3868], 'maturation': [3872, 4144], '(MA3),': [3878], 'A4c': [3879], '(MA4c),': [3880], 'A4b': [3882], '(MA4a,': [3883], '-b)': [3884], '(MA5)': [3887], 'left': [3892, 4155], 'side': [3893, 3918, 4156], 'panel.': [3896, 3921, 4159], 'Lane': [3897, 4160], 'M': [3898, 4161], 'corresponds': [3899], 'size': [3903, 3906, 4165, 4413], 'marker.': [3904, 4166], 'base': [3911], 'pairs': [3912], 'right': [3917], 'C1': [3922], '(C1)': [3936], 'A4b,': [3941], '4:4': [3946, 3980], 'mixture,': [3948], 'without': [3951], 'addition': [3952], '(C2).': [3957], 'C3': [3966, 3993], 'C4,': [3968], '(C3)': [3981], '1:7': [3984], '(C4)': [3985], 'mixture.': [3987], 'calculated': [3995, 4009], 'data': [3997, 4011, 4477], 'C4': [4007], 'shown.View': [4015], 'Large': [4016, 4225], 'Image': [4017, 4226], 'Figure': [4018, 4227], 'ViewerDownload': [4019, 4228], '(PPT)Fig.': [4020], '3Differential': [4021], 'extract.': [4039], 'Assays': [4050], '8': [4054, 4295], '(lane': [4062], '2)': [4063], '(lanes': [4076], '3–6,': [4077], 'respectively).': [4078], 'more': [4084], 'unidentified': [4085], 'lariat': [4086, 4137], 'compounds': [4087, 4138], 'formed': [4088], '(NE)': [4095], 'indicated.': [4097], 'effect': [4099], 'concentration': [4103], 'efficiency.': [4106], 'Transcript': [4107], 'SRp40.': [4129], 'A': [4130, 4221, 4604], '(L),': [4139], '(MA3,': [4146], 'MA4a,': [4147], 'b,': [4148], 'MA5)': [4150], 'histogram': [4168], 'experiment': [4180], 'Error': [4184], 'bars': [4185], 'represent': [4186], 'values,': [4192], 'linked': [4193], 'radioactivity': [4199], 'bands': [4202], 'gel.': [4205], 'C2': [4206], 'respectively.View': [4224], '(PPT)': [4229], 'Ex': [4230], 'Vivo': [4231], 'Assays—HeLa': [4233], '60-mm': [4236], 'plastic': [4237], 'Petri': [4238], 'dishes': [4239], 'calcium': [4244], 'phosphate': [4245], 'coprecipitation': [4246], 'technique': [4247], '(46Chen': [4251], 'Okayama': [4253], '1987;': [4258], '7:': [4259], '2745-2752Crossref': [4260], '(4816)': [4263], 'μgof': [4268], '50–400': [4272], 'overexpressing': [4276], 'Carrier': [4279], 'BSSK': [4280], 'added': [4283], 'transfections': [4286], 'up': [4287], 'total': [4290, 4558], 'amount': [4291], 'μg.': [4296], 'Total': [4297], 'isolated': [4301], 'transfected': [4304, 4481], '48': [4307], 'RNA-solv': [4313], 'Reagent': [4314], '(Omega': [4315], 'Bio-Tek),': [4316], 'treated': [4320], 'DNase.': [4322], 'Three': [4323], 'μg': [4324], 'reverse-transcribed': [4328], 'Moloney': [4331], 'murine': [4332], 'leukemia': [4333], 'virus-reverse': [4334], 'transcriptase': [4335], 'according': [4336], "supplier's": [4339], 'specifications': [4340], '(Invitrogen),': [4341], 'oligonucleotide': [4343, 4373], 'ACC15': [4344], '(5′-TTCACTAATCGAATGGATC-3′,': [4345], 'pNL4-3': [4350], '8445': [4354], '8463)': [4356], 'primer.': [4359], 'About': [4360], '10%': [4361], 'RT': [4366], 'PCR-amplified': [4369], 'forward': [4372], '2143': [4374], '(5′-GGCTTGCTGAAGCGCGCACGGCAAGAGG-3′,': [4375], 'pNL4–3': [4379, 4400], '700–727),': [4384], '2144,': [4388], 'spans': [4390], 'splice': [4395], '(5′-TTGGAGGTGGGTTGCTTTGATAGAG-3′,': [4397], '6029–6041': [4404], '8369–8381).': [4406], 'selectively': [4408], '1.8-kb': [4411], 'HIV': [4412], 'class': [4414], 'Amplification': [4416], 'cycles,': [4421], 'order': [4423], 'detect': [4425], 'minor': [4429], 'bands.': [4430], 'nondenaturing': [4441], 'gel,': [4442], 'Typhoon': [4445], '8600': [4446], 'imager': [4447], 'scan': [4453], 'ethidium': [4457], 'bromide': [4458], 'staining.': [4459], 'Biosciences).': [4467], 'cDNAs': [4470], 'reference': [4474], 'monoclonal': [4563, 4605], 'antibody': [4564, 4606], '10H3': [4565], 'directed': [4566, 4579, 4607], 'against': [4567, 4580, 4608], 'antibodies': [4578], '(MaTG0020),': [4613], 'generous': [4615], 'gift': [4616], 'Aubertin,': [4620], 'Wester': [4626]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2052135311', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T19:36:30.895702', 'created_date': '2016-06-24'}
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