Title: Gas‐liquid chromatographic analysis of synovial fluid. Succinic acid and lactic acid as markers for septic arthritis
Abstract: Abstract Nonvolatile short‐chain fatty acids from 80 synovial fluids were quantified by gas‐liquid chromatography. Succinic acid was detectable in all 23 septic synovial fluids infected with either gram‐positive or gramnegative organisms and in only 5 of 57 nonseptic synovial fluids. Lactic acid was present in all of the effusions but was correlated with septic arthritis only when present in concentrations greater than 250 mg%. Neither short‐chain fatty acid was more sensitive than high white blood cell counts (>50,000 mm 3 ) or depressed glucose concentration (<40 mg/dl) in diagnosing septic arthritis before antibiotic therapy; however, the detection of succinic acid was helpful in identifying patients with septic arthritis who had been given antibiotic treatment before arthrocentesis. Thus, gas‐liquid chromatography, a rapid and sensitive method for the detection of short‐chain fatty acids, may complement the currently available methods used to diagnose septic arthritis.
Publication Year: 1982
Publication Date: 1982-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 35
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