Title: The interaction of cocaine and propranolol with catecholamines on guinea pig trachea
Abstract: Calculated log dose-response lines for isoprenaline, adrenaline and noradrenaline were obtained from several guinea pig tracheal chain preparations. Cocaine (10−2 mM) potentiated responses to noradrenaline more than adrenaline and had much less effect on isoprenaline. Propranolol (10−3nM) blocked adrenaline more than isoprenaline which was blocked more than noradrenaline but, when cocaine was also present, isoprenaline and noradrenaline were equally blocked but adrenaline was blocked to a greater extent. A cocaine-sensitive adrenergic uptake mechanism is considered to be operating in normal preparations, but, when high doses of catecholamines are used, this uptake is less important and a second uptake may operate.
Publication Year: 1967
Publication Date: 1967-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 34
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