Publication Information

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'abstract_inverted_index': {'Wild-type': [0, 229, 523, 1819], 'p53': [1, 14, 84, 111, 118, 169, 191, 210, 230, 243, 313, 340, 347, 398, 420, 439, 462, 511, 524, 579, 635, 689, 710, 740, 865, 875, 1007, 1057, 1072, 1086, 1149, 1153, 1174, 1276, 1297, 1369, 1379, 1388, 1394, 1406, 1560, 1639, 1763, 1788, 1795, 1808, 1862, 1889, 2042, 2128, 2168, 2211, 2230, 2242, 2285, 2289, 2314, 2318, 2330, 2446, 2523, 2653, 2829, 2839, 2938, 2975, 2986, 3014, 3030, 3034, 3097, 3129, 3141, 3150, 3152, 3160, 3179, 3193, 3195, 3203, 3265, 3322, 3351, 3354, 3372, 3375, 3383, 3387, 3412, 3426, 3429, 3445, 3482, 3495, 3513, 3550, 3581, 3619, 3626, 3628, 3631, 3634, 3646, 3672, 3695, 3713, 3736, 3760, 3762, 3766, 3802, 3815, 3841, 3855, 3869, 3954, 3959, 3976, 3994, 4024, 4062, 4083, 4115, 4128, 4149, 4194, 4217, 4234, 4247, 4293, 4314, 4328, 4342], 'is': [2, 129, 165, 231, 358, 394, 463, 505, 512, 519, 525, 531, 571, 620, 704, 1167, 1176, 1280, 1474, 1626, 1824, 1858, 2440, 3137, 3274, 3669, 3737, 3950, 4048, 4056, 4154], 'a': [3, 21, 38, 49, 61, 155, 184, 232, 250, 267, 278, 290, 384, 413, 526, 624, 629, 1136, 1409, 1450, 1610, 1646, 1729, 1848, 1878, 1884, 1970, 2251, 2449, 2529, 2604, 2968, 3155, 3198, 3225, 3237, 3252, 3258, 3338, 3462, 3658, 3789, 3825, 3833, 3902, 3983, 4131, 4259], 'conformationally': [4, 233], 'labile': [5, 234], 'protein': [6, 235, 461, 529, 2620, 2674], 'that': [7, 34, 103, 123, 141, 236, 263, 332, 352, 370, 576, 736, 1066, 1078, 1175, 1404, 1462, 1543, 1724, 1779, 1800, 1890, 2532, 3098, 3273, 3316, 3400, 3451, 3490, 3747, 4015, 4037, 4053, 4110, 4145], 'undergoes': [8, 237], 'nuclear-cytoplasmic': [9, 238], 'shuttling.': [10, 239], 'MDM2-mediated': [11, 240, 1140], 'ubiquitination': [12, 57, 81, 85, 105, 142, 177, 241, 286, 310, 314, 334, 371, 406, 1141, 1569, 1758, 1781, 1812, 1836, 1870, 3859, 3912, 3919, 3948, 4045, 4054, 4126, 4161, 4177], 'promotes': [13, 222, 242, 451, 1152, 1816], 'nuclear': [15, 22, 107, 149, 170, 192, 223, 244, 251, 336, 378, 399, 421, 452, 885, 894, 924, 1008, 1089, 1154, 1203, 1286, 1784, 1817, 1843, 1863, 1903, 3200, 3278, 3325, 3340, 3452, 3478, 3510, 3587, 3591, 3597, 3851, 3870, 3955, 3977, 3997, 4027, 4063, 4111, 4146, 4260, 4275], 'export': [16, 23, 171, 224, 245, 252, 400, 453, 886, 895, 925, 1009, 1090, 1155, 1204, 1864, 3279, 3479, 3852, 3871, 3978, 4064, 4112, 4170], 'by': [17, 131, 201, 246, 360, 430, 706, 1091, 1156, 1399, 1479, 1826, 2064, 2247, 2422, 2459, 2526, 2685, 2789, 2813, 2905, 2916, 3039, 3121, 3131, 3181, 3554, 3566, 3643, 3655, 3666, 3726, 3785, 3830, 3872, 4221, 4319], 'exposing': [18, 247, 1157], 'or': [19, 206, 248, 435, 481, 1144, 1158, 1201, 1412, 1526, 1541, 2004, 2045, 2332, 2649, 2660, 2994, 3102, 3116, 3134, 3589, 3596, 3601, 3715, 3765, 3772, 4031, 4211, 4306], 'activating': [20, 249, 1159], 'signal': [24, 253], '(NES)': [25, 254, 888], 'in': [26, 45, 89, 133, 143, 158, 172, 255, 274, 318, 362, 372, 387, 401, 465, 521, 536, 633, 687, 696, 700, 860, 871, 952, 965, 1010, 1085, 1138, 1147, 1171, 1178, 1277, 1295, 1322, 1393, 1407, 1448, 1645, 1680, 1734, 1767, 1806, 1828, 1837, 1851, 1865, 1880, 1887, 1896, 1938, 1973, 2009, 2059, 2603, 2754, 2772, 2825, 2896, 2907, 2920, 2992, 3013, 3018, 3145, 3169, 3186, 3214, 3217, 3248, 3269, 3350, 3360, 3365, 3410, 3444, 3464, 3500, 3534, 3639, 3683, 3867, 3880, 3905, 3962, 3990, 4012, 4034, 4088, 4097, 4100, 4121, 4141, 4157, 4224, 4226, 4263, 4269], 'the': [27, 46, 75, 91, 135, 173, 197, 203, 226, 256, 275, 304, 320, 364, 402, 426, 432, 455, 466, 621, 858, 880, 957, 962, 966, 1053, 1081, 1148, 1160, 1179, 1192, 1202, 1296, 1323, 1366, 1383, 1467, 1475, 1627, 1631, 1638, 1674, 1735, 1752, 1768, 1771, 1830, 1866, 1899, 1974, 2010, 2025, 2065, 2099, 2110, 2178, 2271, 2278, 2294, 2301, 2324, 2335, 2338, 2345, 2350, 2355, 2360, 2365, 2370, 2375, 2380, 2385, 2394, 2399, 2404, 2409, 2415, 2426, 2464, 2470, 2481, 2487, 2498, 2504, 2519, 2534, 2608, 2625, 2681, 2700, 2720, 2773, 2785, 2800, 2831, 2845, 2921, 2936, 2944, 2956, 3019, 3025, 3043, 3132, 3177, 3210, 3228, 3249, 3334, 3347, 3382, 3396, 3411, 3416, 3434, 3436, 3455, 3481, 3491, 3509, 3535, 3546, 3579, 3613, 3617, 3667, 3670, 3678, 3684, 3710, 3877, 3906, 3986, 4004, 4098, 4204, 4241, 4245, 4264, 4279, 4336, 4340], 'C': [28, 96, 138, 257, 325, 367, 1150, 1772, 1833, 2264, 2520, 3271, 3413, 3536, 3607], 'terminus': [29, 139, 258, 368, 968, 1151, 2521, 3272], 'of': [30, 71, 175, 214, 259, 300, 404, 443, 469, 623, 638, 685, 709, 836, 854, 882, 1056, 1080, 1142, 1181, 1275, 1289, 1368, 1373, 1387, 1452, 1489, 1496, 1530, 1536, 1612, 1634, 1677, 1747, 1761, 1813, 1868, 1962, 2040, 2049, 2067, 2072, 2085, 2105, 2161, 2177, 2237, 2277, 2283, 2312, 2522, 2551, 2560, 2619, 2643, 2652, 2673, 2708, 2728, 2757, 2763, 2775, 2923, 3029, 3128, 3140, 3176, 3232, 3320, 3329, 3403, 3425, 3454, 3474, 3494, 3512, 3527, 3578, 3625, 3677, 3734, 3744, 3795, 3800, 3853, 4113, 4148, 4171, 4266], 'p53.': [31, 260, 883, 1622, 3124, 3233], 'We': [32, 261, 3314, 3972], 'observed': [33, 262, 1061, 1723], 'cancer-derived': [35, 204, 264, 433, 1726, 3321], 'p53s': [36, 59, 73, 265, 288, 302, 1461, 1491, 1532, 1549, 1679, 1727, 1749, 2932, 2998, 3235, 3256, 3476, 3529, 3746, 4173], 'with': [37, 60, 266, 289, 478, 484, 1062, 1196, 1401, 1492, 1728, 1944, 2037, 2046, 2082, 2098, 2300, 2548, 2592, 2616, 2640, 2670, 2705, 2725, 2734, 2935, 2948, 2962, 3042, 3093, 3113, 3236, 3257, 3504, 3543, 3557, 3616, 3645, 3657, 3707, 3716, 3728, 3750, 3757, 3773, 3780, 3788, 3811, 3824, 3832, 4010, 4032, 4050, 4189, 4231, 4244, 4289, 4322, 4339], 'mutant': [39, 72, 110, 127, 188, 268, 301, 339, 356, 417, 1065, 1413, 1460, 1480, 1490, 1531, 1621, 1678, 1730, 1748, 1762, 1787, 1807, 1822, 2243, 2661, 3117, 3168, 3239, 3475, 3493, 3528, 3650, 3745, 3953, 4114, 4172], '(primary': [40, 64, 269, 293], 'antibody': [41, 65, 270, 294, 2646, 2656, 2663, 2834, 2840, 2848, 2852, 2940, 2951, 3560, 3679], '1620-/pAb240+)': [42, 271], 'conformation': [43, 272, 1384, 1395, 1415, 1732, 3026, 3035, 3229, 3240, 3261, 3424, 3446, 3624], 'localized': [44, 273, 1733, 3208], 'cytoplasm': [47, 276, 1180, 1736, 3213, 3250, 4005], 'to': [48, 56, 100, 109, 147, 167, 216, 277, 285, 329, 338, 376, 396, 445, 508, 849, 873, 1070, 1370, 1389, 1459, 1533, 1553, 1557, 1620, 1629, 1742, 1776, 1786, 1841, 1860, 2024, 2114, 2116, 2249, 2309, 2518, 2579, 2623, 2817, 2827, 3031, 3251, 3336, 3395, 3433, 3461, 3519, 3522, 3599, 3700, 4003, 4043, 4060, 4208, 4308], 'greater': [50, 279, 3253], 'extent': [51, 280, 3254, 3435], 'and': [52, 78, 95, 137, 140, 189, 218, 281, 307, 324, 366, 369, 418, 447, 515, 530, 580, 741, 748, 839, 857, 961, 1058, 1184, 1282, 1364, 1385, 1568, 1614, 1637, 1643, 1737, 1755, 1770, 1811, 1832, 1835, 1907, 1910, 1949, 1953, 1964, 1968, 2074, 2095, 2154, 2173, 2215, 2228, 2258, 2266, 2273, 2287, 2304, 2316, 2337, 2341, 2413, 2429, 2477, 2494, 2511, 2539, 2554, 2577, 2595, 2680, 2712, 2732, 2760, 2784, 2804, 2815, 2844, 2947, 2977, 3001, 3007, 3023, 3027, 3049, 3151, 3159, 3163, 3190, 3194, 3206, 3212, 3230, 3245, 3353, 3356, 3369, 3374, 3386, 3428, 3438, 3562, 3571, 3633, 3649, 3817, 3968, 4138, 4187, 4195, 4233, 4284, 4327], 'displayed': [53, 282, 1738, 3154, 3197, 3377, 4130, 4258], 'increased': [54, 283, 482, 1740, 3698], 'susceptibility': [55, 284, 1741, 3699], 'than': [58, 287, 3255], 'more': [62, 291, 1145, 3259, 3339], 'wild-type': [63, 124, 159, 190, 292, 353, 388, 419, 1006, 1173, 1410, 1468, 1559, 1635, 1852, 1888, 2127, 2167, 2226, 2654, 3101, 3114, 3133, 3148, 3157, 3192, 3260, 3437, 3647, 3854, 3975, 3993, 4023], '1620+/pAb240-)': [66, 295], 'conformation.': [67, 119, 296, 348, 1796, 3142, 3171, 3466], 'The': [68, 212, 297, 441, 458, 683, 851, 1744, 2582, 2627, 2749, 2768, 2797, 2982, 3125, 3610, 3662, 3732, 3793, 3837, 4238, 4297, 4333], 'cytoplasmic': [69, 298, 475, 1273, 1745, 3318, 3379, 3401, 3472, 3600, 3603, 4087, 4133], 'localization': [70, 108, 299, 337, 881, 1274, 1386, 1746, 1785, 3028, 3175, 3231, 3319, 3359, 3402, 3473, 3526, 3551, 3577, 3620, 3961, 4134, 4218, 4235, 4262, 4316, 4330], 'required': [74, 303, 1052, 3275, 3951, 4057], 'C-terminal': [76, 219, 227, 305, 448, 456, 958, 1054, 1083, 1161, 1753, 1900, 2530, 3005, 3348, 3483], 'NES': [77, 306, 1055, 1754, 1901, 2281, 3006, 3268, 3331, 3349, 3385, 3389, 3409, 3417, 3456, 3492, 3515, 3533, 3636, 3768], 'an': [79, 308, 572, 1063, 1528, 1739, 1756, 2259, 3008, 3138, 3267, 3407, 3520, 3531, 3558, 3729, 3781, 3857, 3946, 4124, 4175, 4323], 'intact': [80, 309, 1757, 3408, 3532, 3858, 3947, 4125, 4176], 'pathway.': [82, 311, 1759, 3860, 4127], 'Mutant': [83, 312, 1548, 4082], 'occurred': [86, 315, 1764], 'at': [87, 316, 533, 1765, 1935, 2002, 2089, 2107, 2254, 2262, 2454, 2467, 2484, 2501, 2597, 2600, 2637, 2690, 2781, 2794, 3431, 3876, 3914, 3921, 3965, 3979, 4018, 4040, 4091, 4103, 4119, 4135, 4151, 4166, 4184, 4303], 'lysines': [88, 220, 317, 449, 1084, 1146, 1766, 1805, 1815, 1892], 'both': [90, 134, 144, 319, 363, 373, 1014, 1829, 1838, 3980, 4136], 'DNA-binding': [92, 321, 898, 928, 1324, 3020], 'domain': [93, 322, 960, 1325, 3021], '(DBD)': [94, 323, 3022], 'terminus.': [97, 326, 1773, 3414, 3537], 'Interestingly,': [98, 327, 1774], 'Lys': [99, 328, 1775], 'Arg': [101, 330, 1777], 'mutations': [102, 331, 1294, 1317, 1380, 1778, 3012, 3418], 'inhibited': [104, 333, 1087, 1780, 3875, 4165], 'restored': [106, 335, 1783], 'but': [112, 161, 341, 390, 1789, 1854, 3917, 4001, 4094], 'had': [113, 342, 1790, 3419], 'no': [114, 343, 1791, 3420], 'apparent': [115, 344, 1792, 3421], 'effect': [116, 345, 1051, 1793, 3422], 'on': [117, 346, 1751, 1794, 1873, 2587, 2893, 3003, 3423, 4123], 'Further': [120, 349], 'studies': [121, 350, 695, 1170, 3866], 'revealed': [122, 351, 692], 'p53,': [125, 128, 160, 354, 357, 389, 953, 1636, 1820, 1823, 1853], 'like': [126, 355, 1538, 1821], 'ubiquitinated': [130, 359, 1825, 3499], 'MDM2': [132, 151, 176, 207, 361, 380, 405, 436, 488, 570, 619, 686, 701, 1004, 1064, 1092, 1198, 1827, 1845, 1869, 2052, 2227, 2851, 3873, 4011, 4033, 4059, 4196, 4257, 4271], 'DBD': [136, 217, 365, 446, 1769, 1831], 'regions': [145, 374, 1839], 'contributes': [146, 375, 1840], 'its': [148, 377, 485, 582, 639, 743, 1068, 1088, 1374, 1546, 1842, 2305, 2430, 3270], 'export.': [150, 193, 379, 422, 1818, 1844], 'binding': [152, 208, 381, 437, 1846], 'can': [153, 382, 577, 737, 877, 1396, 1463, 3036, 3441, 4163], 'induce': [154, 383], 'conformational': [156, 163, 198, 385, 392, 427, 1801, 1849, 1856, 1885], 'change': [157, 164, 199, 386, 393, 428, 1802, 1850, 1857, 1886, 3463], 'this': [162, 195, 391, 424, 517, 1164, 1720, 1855, 2630, 3330, 3863], 'insufficient': [166, 395, 1859], 'promote': [168, 397, 581, 742, 1071, 1545, 1861, 4061], 'absence': [174, 403, 1867], 'activity.': [178, 407, 1871, 4046], 'Taken': [179, 408], 'together,': [180, 409], 'these': [181, 410, 837, 855, 1278, 1473, 1625, 1814, 1874, 3404, 3469], 'results': [182, 411, 1283, 1798, 3223, 3470, 4250, 4346], 'support': [183, 412, 3224], 'stepwise': [185, 414], 'model': [186, 415, 1137, 1879], 'for': [187, 416, 1809, 1893, 1902, 2092, 2344, 2349, 2354, 2359, 2364, 2369, 2374, 2379, 2384, 2389, 2393, 2398, 2403, 2408, 2414, 2589, 2613, 2634, 2677, 2687, 2714, 2778, 2791, 2807, 2821, 2910, 2985, 2989, 3123, 3276, 3862, 3952, 3985, 4058, 4214, 4311], 'In': [194, 423, 1163, 3083, 3467, 4021], 'model,': [196, 425], 'induced': [200, 429], 'either': [202, 431, 472, 1197, 1408, 1487, 3100, 3586, 3770, 4209, 4301], 'mutation': [205, 434, 1079, 1972, 3328, 3904], 'precedes': [209, 438], 'ubiquitination.': [211, 440, 1073, 1743, 1894, 3701], 'addition': [213, 442, 872, 2066], 'ubiquitin': [215, 444, 2055, 2182], 'then': [221, 450, 2096, 2268, 2555, 2585, 2752, 3111, 3327, 4300], 'via': [225, 454, 3480], 'NES.': [228, 457, 1162, 3484], 'tumor': [459], 'suppressor': [460], 'inactivated': [464], 'vast': [467], 'majority': [468, 4265], 'human': [470, 1290], 'cancers,': [471], 'through': [473, 693], 'mutation,': [474, 2347, 2352, 2357, 2362, 2367, 2372, 2377, 2382, 2387, 2391, 2396, 2401, 2406, 2411, 2417], 'sequestration,': [476], 'interaction': [477], 'viral': [479], 'oncoproteins,': [480], 'interactions': [483], 'negative': [486, 630], 'regulator,': [487], '(1Vousden': [489], 'K.H.': [490, 608, 1121], 'Lu': [491, 1506], 'X.': [492], 'Nat.': [493, 1022, 1039, 3286, 3303, 3889, 4071], 'Rev.': [494], 'Cancer.': [495], '2002;': [496, 1356, 2876], '2:': [497, 1026, 1043, 3290, 3307, 3893, 4075], '594-604Crossref': [498], 'PubMed': [499, 550, 565, 598, 613, 659, 678, 724, 772, 794, 828, 986, 999, 1028, 1045, 1107, 1128, 1224, 1245, 1265, 1311, 1337, 1359, 1441, 1521, 1582, 1604, 1664, 1705, 1717, 1993, 2149, 2197, 2884, 3078, 3292, 3309, 3895, 3938, 4077], 'Scopus': [500, 551, 566, 599, 614, 660, 679, 725, 773, 795, 829, 987, 1000, 1029, 1046, 1108, 1129, 1225, 1246, 1266, 1312, 1338, 1360, 1442, 1522, 1583, 1605, 1665, 1706, 1994, 2150, 2198, 2885, 3079, 3293, 3310, 3896, 3939, 4078], '(2694)': [501], 'Google': [502, 553, 568, 601, 616, 662, 681, 727, 775, 797, 831, 989, 1002, 1031, 1048, 1110, 1131, 1227, 1248, 1268, 1314, 1340, 1362, 1426, 1444, 1524, 1585, 1607, 1667, 1708, 1718, 1996, 2152, 2200, 2887, 3063, 3081, 3295, 3312, 3898, 3941, 4080], 'Scholar).': [503, 569, 617, 682, 728, 832, 1003, 1049, 1132, 1269, 1315, 1445, 1608, 1668, 1997, 2888, 3082, 3313, 3942, 4081], 'It': [504, 1074, 3485], 'therefore': [506], 'important': [507], 'determine': [509], 'how': [510, 516], 'normally': [513], 'regulated': [514], 'regulation': [518], 'altered': [520], 'cancer.': [522], 'short': [527], 'lived': [528], 'expressed': [532, 3999, 4029], 'low': [534], 'levels': [535], 'most': [537, 3215], 'normal': [538], 'cells': [539, 1011, 1932, 1956, 1999, 2029, 2034, 2115, 2545, 2583, 2890, 2991, 3088, 3216, 3501, 3540, 3615, 3704, 3754, 3808, 3882, 3910, 3964, 4014, 4036, 4090, 4102, 4158, 4181, 4205, 4225, 4243, 4283, 4286, 4298, 4338], '(2Maki': [540], 'C.G.': [541, 1021, 2872, 3285], 'Howley': [542, 2220], 'P.M.': [543], 'Mol.': [544, 559, 1101, 1122, 1260, 1987, 2143, 3932], 'Cell.': [545, 560, 652, 819, 1102, 1123, 1577, 1696, 1988, 2144, 2190, 3933], 'Biol.': [546, 561, 784, 1024, 1041, 1103, 1124, 1511, 1989, 2145, 2874, 3288, 3305, 3891, 3934, 4073], '1997;': [547, 595, 610], '17:': [548], '355-363Crossref': [549], '(298)': [552], 'Scholar,': [554, 602, 663, 776, 798, 990, 1032, 1111, 1228, 1249, 1341, 1427, 1586, 1709, 3064, 3296], '3Maltzman': [555], 'W.': [556, 804, 1230, 1507], 'Czyzyk': [557], 'L.': [558, 1096, 1234, 1503, 1594], '1984;': [562, 3935], '4:': [563, 3936], '1689-1694Crossref': [564], '(813)': [567], 'E3': [573], 'ubiquitin-protein': [574, 731], 'ligase': [575], 'bind': [578, 739], 'rapid': [583], 'ubiquitin-mediated': [584], 'proteolysis': [585], '(4Haupt': [586], 'Y.': [587, 802, 992, 994, 1238, 1501], 'Maya': [588], 'R.': [589, 715, 816, 1232, 1345, 1431, 1433, 2870, 3068, 3070, 3931], 'Kazaz': [590], 'A.': [591, 1419, 1573, 3056], 'Oren': [592], 'M.': [593, 780, 1236, 1300, 1343, 1347, 1421, 1592, 3058], 'Nature.': [594, 609, 674, 720, 768], '387:': [596, 611], '296-299Crossref': [597], '(3659)': [600], '5Kubbutat': [603], 'M.H.': [604], 'Jones': [605], 'S.N.': [606], 'Vousden': [607, 1120], '299-303Crossref': [612], '(2814)': [615], 'Importantly,': [618, 3415], 'product': [622], 'p53-inducible': [625], 'gene,': [626], 'thus': [627], 'establishing': [628], 'feedback': [631], 'loop': [632], 'which': [634, 697, 861, 1139, 1172, 1497, 1558, 1881, 3218, 3868, 3900, 4227, 4270], 'increases': [636], 'expression': [637, 1372, 1535], 'own': [640], 'inhibitor': [641, 1205], '(6Momand': [642], 'J.': [643, 782, 783, 982, 1094, 1220, 1240, 1417, 1437, 1509, 1510, 1571, 1576, 1600, 1660, 2134, 2138, 2868, 2873, 3054, 3074, 3927], 'Zambetti': [644], 'G.P.': [645], 'Olson': [646], 'D.C.': [647], 'George': [648, 670], 'D.': [649, 751, 757, 1098, 1253, 1302, 1590, 1658, 2136], 'Levine': [650], 'A.J.': [651], '1992;': [653, 675], '69:': [654], '1237-1245Abstract': [655], 'Full': [656, 789, 791, 823, 825, 1516, 1518, 1700, 1702, 2194, 2879, 2881], 'Text': [657, 790, 792, 824, 826, 1517, 1519, 1701, 1703, 2195, 2880, 2882], 'PDF': [658, 793, 827, 1520, 1704, 2196, 2883], '(2776)': [661], '7Oliner': [664], 'J.D.': [665], 'Kinzler': [666], 'K.W.': [667], 'Meltzer': [668], 'P.S.': [669], 'D.L.': [671], 'Vogelstein': [672, 1303], 'B.': [673, 808, 1304], '358:': [676], '80-83Crossref': [677], '(1790)': [680], 'importance': [684, 853], 'regulating': [688], 'has': [690, 2129], 'been': [691, 734, 842, 868, 950, 1457, 1618, 2130], 'genetic': [694], 'embryonic': [698], 'lethality': [699], 'knockout': [702], 'mice': [703], 'rescued': [705], 'simultaneous': [707], 'knock-out': [708, 1920], '(8Montes': [711], 'de': [712], 'Oca': [713], 'Luna': [714], 'Wagner': [716], 'D.S.': [717], 'Lozano': [718, 813], 'G.': [719, 814, 1650], '1995;': [721, 2191], '378:': [722], '203-206Crossref': [723], '(1196)': [726], 'Recently,': [729], 'other': [730, 963, 1453], 'ligases': [732, 856], 'have': [733, 841, 866, 949, 1456, 1617], 'identified': [735, 843, 951], 'also': [738, 878, 1076, 1381, 1551, 1782, 2321, 3487, 3973, 4117], 'degradation,': [744, 876], 'including': [745], 'Pirh2,': [746], 'Cop1,': [747], 'Chip': [749], '(9Dornan': [750], 'Wertz': [752], 'I.': [753], 'Shimizu': [754], 'H.': [755, 765, 806, 1588], 'Arnott': [756], 'Frantz': [758], 'G.D.': [759], 'Dowd': [760], 'P.': [761, 1353, 1656], "O'Rourke": [762], 'K.': [763, 1329, 1685], 'Koeppen': [764], 'Dixit': [766], 'V.M.': [767], '2004;': [769, 1714], '429:': [770], '86-92Crossref': [771], '(585)': [774], '10Esser': [777], 'C.': [778, 1331, 1505, 1575], 'Scheffner': [779], 'Hohfeld': [781], 'Chem.': [785, 1512, 2875], '2005;': [786, 1661], '280:': [787], '27443-27448Abstract': [788], '(218)': [796], '11Leng': [799], 'R.P.': [800], 'Lin': [801], 'Ma': [803], 'Wu': [805], 'Lemmers': [807], 'Chung': [809], 'S.': [810, 818, 2187], 'Parant': [811], 'J.M.': [812, 970, 1208], 'Hakem': [815], 'Benchimol': [817], '2003;': [820, 1697], '112:': [821], '779-791Abstract': [822], '(597)': [830], 'At': [833], 'least': [834, 3432, 4120], 'some': [835, 1495], '(PirH2': [838], 'Cop1)': [840], 'as': [844, 1566, 2007, 2334, 2862, 2943, 2955, 3242, 3263, 3585, 3819, 3982], 'p53-responsive': [845], 'gene': [846, 1298], 'products,': [847], 'similar': [848], 'MDM2.': [850], 'relative': [852, 3126], 'context': [859], 'they': [862, 3219], 'may': [863, 1484, 1561, 1672], 'regulate': [864], 'not': [867, 1060, 3459, 3517, 4273], 'fully': [869], 'clarified.MDM2,': [870], 'promoting': [874], 'affect': [879, 1382], 'Two': [884], 'signals': [887], '3The': [889, 919], 'abbreviations': [890, 920], 'used': [891, 921, 2824, 3682], 'are:': [892, 922], 'NES,': [893, 923, 3630], 'signal;': [896, 926], 'DBD,': [897, 927], 'domain;': [899, 929], 'DAPI,': [900, 930], '4,6-diamidino-2-phenylindole;': [901, 931], 'pAb,': [902, 932], 'primary': [903, 933, 2945], 'antibody;': [904, 934], 'TEV,': [905, 935], 'tobacco': [906, 936], 'etch': [907, 937], 'virus;': [908, 938], 'HA,': [909, 939], 'hemagglutinin;': [910, 940], 'WT,': [911, 941], 'wild': [912, 942], 'type;': [913, 943], 'DKO,': [914, 944], 'double': [915, 945, 1919], 'knockout;': [916, 946], 'Ub,': [917, 947], 'ubiquitin.': [918, 948], 'one': [954, 1143], 'located': [955, 964], 'within': [956], 'oligomerization': [959], 'N': [967, 2256, 3593], '(12Stommel': [969, 1207], 'Marchenko': [971, 1209], 'N.D.': [972, 1210], 'Jimenez': [973, 1211], 'G.S.': [974, 1212], 'Moll': [975, 1213], 'U.M.': [976, 1214], 'Hope': [977, 1215], 'T.J.': [978, 1216], 'Wahl': [979, 1217], 'G.M.': [980, 1218], 'EMBO': [981, 1219, 1436, 3073], '1999;': [983, 1221], '18:': [984, 1222], '1660-1672Crossref': [985, 1223], '(601)': [988, 1226], '13Zhang': [991], 'Xiong': [993], 'Science.': [995, 1307], '2001;': [996, 1104, 1125, 1262, 1513], '292:': [997], '1910-1915Crossref': [998], '(310)': [1001], 'promoted': [1005], 'transiently': [1012], 'co-expressing': [1013], 'proteins': [1015, 1537, 3180, 3582], '(14Geyer': [1016, 3280], 'R.K.': [1017, 3281], 'Yu': [1018, 3282], 'Z.K.': [1019, 3283], 'Maki': [1020, 2871, 3284], 'Cell': [1023, 1040, 1712, 2119, 3287, 3304, 3890, 4072], '2000;': [1025, 1042, 1242, 1334, 2146, 3289, 3306, 3892, 4074], '569-573Crossref': [1027, 3291], '(296)': [1030, 3294], '15Boyd': [1033, 3297], 'S.D.': [1034, 3298, 3884, 4066], 'Tsai': [1035, 3299, 3885, 4067], 'K.Y.': [1036, 3300, 3886, 4068], 'Jacks': [1037, 3301, 3887, 4069], 'T.': [1038, 1327, 2866, 3302, 3888, 4070], '563-568Crossref': [1044, 3308, 3894, 4076], '(285)': [1047, 3311, 3897, 4079], 'This': [1050, 1482, 2164, 3398, 3449, 4047, 4108], 'was': [1059, 1075, 2062, 2112, 2155, 2202, 2420, 2516, 2611, 2632, 2766, 2805, 2853, 2859, 2960, 2987, 3099, 3458, 3497, 3516, 3552, 3564, 3583, 3637, 3874, 3995, 4085, 4219, 4229, 4236, 4272, 4317, 4331], 'lacks': [1067], 'ability': [1069, 1367, 1628], 'reported': [1077], 'six': [1082], '(16Gu': [1093], 'Nie': [1095], 'Wiederschain': [1097], 'Yuan': [1099, 2141, 2158], 'Z.M.': [1100, 2142], '21:': [1105, 1126], '8533-8546Crossref': [1106], '(76)': [1109], '17Lohrum': [1112], 'M.A.': [1113, 1349], 'Woods': [1114], 'D.B.': [1115], 'Ludwig': [1116], 'R.L.': [1117], 'Balint': [1118], 'E.': [1119, 1652], '8521-8532Crossref': [1127], '(194)': [1130], 'These': [1133, 1270, 1316, 1797, 1931, 3222, 3909], 'findings': [1134, 1271, 4052], 'supported': [1135], 'regard,': [1165], 'it': [1166, 4095, 4228], 'worth': [1168], 'noting': [1169], 'sequestered': [1177], 'breast,': [1182], 'liver,': [1183], 'neuroblastoma': [1185], 'cancer': [1186, 1681], 'cell': [1187, 1916, 2543, 3108, 3641], 'lines': [1188], 'shuttled': [1189], 'back': [1190], 'into': [1191, 2171, 2270, 2557], 'nucleus': [1193, 3211, 4099], 'upon': [1194], 'treatment': [1195], 'antisense': [1199], 'oligonucleotides,': [1200], 'leptomycin-B': [1206], '18Lu': [1229], 'Pochampally': [1231], 'Chen': [1233, 1239, 1502, 1508, 2135], 'Traidej': [1235], 'Wang': [1237], 'Oncogene.': [1241, 1422, 3059], '19:': [1243, 1357], '232-240Crossref': [1244], '(69)': [1247], '19Rodriguez-Lopez': [1250], 'A.M.': [1251], 'Xenaki': [1252], 'Eden': [1254], 'T.O.': [1255], 'Hickman': [1256], 'J.A.': [1257], 'Chresta': [1258], 'C.M.': [1259], 'Pharmacol.': [1261], '59:': [1263], '135-143Crossref': [1264], '(46)': [1267, 2886], 'suggested': [1272, 1799], 'cancers': [1279, 1291], 'MDM2-dependent': [1281, 3277], 'from': [1284, 1466, 1486, 1527, 1926, 1958, 2156, 2203, 2218, 2233, 2629, 3865, 4251, 4278, 4347], 'excessive': [1285], 'export.Over': [1287], '50%': [1288], 'harbor': [1292, 1969, 3901], 'missense': [1293], '(20Hollstein': [1299], 'Sidransky': [1301], 'Harris': [1305, 1350], 'C.C.': [1306, 1351], '1991;': [1308], '253:': [1309], '49-53Crossref': [1310], '(7412)': [1313], 'are': [1318, 1550, 1914, 3574, 3797, 4255, 4351], 'found': [1319], 'almost': [1320, 3016, 3393], 'exclusively': [1321, 3017], '(21Soussi': [1326], 'Dehouche': [1328], 'Beroud': [1330], 'Hum.': [1332, 1354], 'Mutat.': [1333, 1355], '15:': [1335], '105-113Crossref': [1336], '(246)': [1339], '22Olivier': [1342], 'Eeles': [1344], 'Hollstein': [1346], 'Khan': [1348], 'Hainaut': [1352], '607-614Crossref': [1358], '(1015)': [1361], 'Scholar)': [1363, 2153, 2201], 'inhibit': [1365, 1630, 4044], 'activate': [1371, 1534], 'downstream': [1375, 2176, 2276], 'target': [1376], 'genes.': [1377], 'Cancer-derived': [1378], 'varying': [1390, 3032], 'extents.': [1391, 3033], 'Changes': [1392], 'be': [1397, 1562, 3037, 3488, 3523, 4164], 'monitored': [1398, 3038, 3174, 3357, 3553, 3638, 3958, 3974, 4220, 4318], 'reactivity': [1400, 3041], 'conformation-specific': [1402, 2655, 2662, 3044, 3652], 'antibodies': [1403, 3045, 3136, 3440], 'recognize': [1405, 3442], '(pAb1620)': [1411, 3115], '(pAb240)': [1414, 3118], '(23Milner': [1416, 3053], 'Cook': [1418, 3055], 'Sheldon': [1420, 3057], '1987;': [1423, 3060], '1:': [1424, 3061], '453-455PubMed': [1425, 3062], '24Gannon': [1428, 3065], 'J.V.': [1429, 3066], 'Greaves': [1430, 3067], 'Iggo': [1432, 3069], 'Lane': [1434, 3071], 'D.P.': [1435, 3072], '1990;': [1438, 3075], '9:': [1439, 3076], '1595-1602Crossref': [1440, 3077], '(936)': [1443, 3080], 'Notwithstanding': [1446], 'changes': [1447, 3443], 'conformation,': [1449, 3158], 'number': [1451, 1611], 'unique': [1454], 'properties': [1455, 1616, 1671], 'ascribed': [1458, 1619], 'distinguish': [1464], 'them': [1465], 'protein.': [1469, 3673, 3804], 'Most': [1470], 'obvious': [1471], 'among': [1472, 1624], 'pronounced': [1476], 'stability': [1477, 1483], 'exhibited': [1478], 'p53s.': [1481, 3549], 'result': [1485], 'association': [1488], 'stabilizing': [1493], 'complexes,': [1494], 'include': [1498], 'Hsp90': [1499], '(25Peng': [1500], 'Li': [1504], '276:': [1514], '40583-40590Abstract': [1515], '(138)': [1523], 'Scholar),': [1525, 3899], 'inability': [1529, 3521], 'MDM2,': [1539, 4232], 'PirH2,': [1540], 'Cop1': [1542], 'could': [1544, 1803], 'degradation.': [1547], 'susceptible': [1552], 'various': [1554], 'post-translational': [1555], 'modifications': [1556], 'relatively': [1563], 'resistant,': [1564], 'such': [1565], 'ribosylation': [1567], '(26Wesierska-Gadek': [1570], 'Bugajska-Schretter': [1572], 'Cerni': [1574], 'Biochem.': [1578, 1599, 1659], '1996;': [1579], '62:': [1580], '90-101Crossref': [1581], '(79)': [1584], '27Shimizu': [1587], 'Saliba': [1589], 'Wallace': [1591], 'Finlan': [1593], 'Langridge-Smith': [1595], 'P.R.': [1596], 'Hupp': [1597], 'T.R.': [1598], '2006;': [1601], '397:': [1602], '355-367Crossref': [1603], '(28)': [1606], 'Finally,': [1609], 'oncogenic': [1613, 1670], 'growth-promoting': [1615], 'Included': [1623], 'transcriptional': [1632], 'activity': [1633, 3913, 3920, 4055, 4162], 'family': [1640], 'members': [1641], 'p73': [1642], 'p63,': [1644], 'dominant-negative': [1647], 'fashion': [1648], '(28Koutsodontis': [1649], 'Vasilaki': [1651], 'Chou': [1653], 'W.C.': [1654, 1691], 'Papakosta': [1655], 'Kardassis': [1657], '389:': [1662], '443-455Crossref': [1663], '(61)': [1666], 'Such': [1669], 'explain': [1673], 'selective': [1675], 'retention': [1676], '(29Irwin': [1682], 'M.S.': [1683, 1711], 'Kondo': [1684], 'Marin': [1686], 'M.C.': [1687], 'Cheng': [1688], 'L.S.': [1689], 'Hahn': [1690], 'Kaelin': [1692], 'Jr.,': [1693], 'W.G.': [1694], 'Cancer': [1695], '3:': [1698, 1715], '403-410Abstract': [1699], '(360)': [1707], '30Irwin': [1710], 'Cycle.': [1713], '319-323Crossref': [1716], 'Scholar).In': [1719], 'study,': [1721], 'we': [1722, 1876, 3173, 3345, 3957], 'certain': [1725], '(pAb1620-/pAb240+)': [1731], 'depended': [1750], 'Ubiquitination': [1760, 3010], 'expose': [1804], 'ubiquitination,': [1810], 'terminus,': [1834], 'induces': [1847, 1883], 'Based': [1872], 'results,': [1875], 'suggest': [1877, 3471], 'MDM2-binding': [1882], 'exposes': [1891, 1898], 'Ubiquitination,': [1895], 'turn,': [1897], 'export.EXPERIMENTAL': [1904], 'PROCEDURESCell': [1905], 'Culture': [1906], 'Transfections—Saos-2': [1908], '(p53-null)': [1909], 'U2OS': [1911, 3539, 3703, 4142, 4285], '(p53': [1912, 3089], 'wild-type)': [1913], 'osteosarcoma': [1915], 'lines.': [1917], 'p53/MDM2': [1918, 3806], '(DKO)': [1921], 'mouse': [1922], 'embryo': [1923], 'fibroblasts': [1924], 'were': [1925, 1933, 1957, 2000, 2013, 2030, 2035, 2080, 2121, 2217, 2232, 2245, 2267, 2291, 2320, 2457, 2474, 2491, 2508, 2546, 2584, 2668, 2683, 2702, 2722, 2751, 2770, 2787, 2811, 2891, 2900, 2914, 2933, 2965, 2980, 3091, 3110, 3165, 3220, 3391, 3541, 3705, 3724, 3748, 3755, 3777, 3809, 3822, 4016, 4038, 4182, 4206, 4276, 4287, 4299], 'Rudy': [1927], 'Alarcon': [1928], '(Stanford': [1929, 2206], 'University).': [1930, 2207], 'maintained': [1934, 2001, 4017, 4302], '37': [1936, 4185], '°C': [1937, 2599, 2639, 3916, 3923, 3967, 4042, 4105, 4140, 4153, 4186, 4213, 4305, 4310], "Dulbecco's": [1939, 2076], 'modified': [1940, 2077], "Eagle's": [1941, 2078], 'medium': [1942, 2079], 'supplemented': [1943], '10%': [1945], 'fetal': [1946], 'bovine': [1947, 2925], 'serum': [1948, 2073, 2926], '100': [1950, 2070], 'μg/ml': [1951], 'penicillin': [1952], 'streptomycin.': [1954], 'ts-20': [1955, 1998, 3881, 3963, 4013, 4035, 4089, 4101, 4180, 4282], 'Harvey': [1959], 'Ozer': [1960, 1985, 3928], '(University': [1961, 2236], 'Medicine': [1963], 'Dentistry,': [1965], 'New': [1966], 'Jersey)': [1967], 'temperature-sensitive': [1971, 3903], 'E1': [1975], 'ubiquitin-activating': [1976, 3907], 'enzyme': [1977], 'system': [1978, 3949], '(31Chowdary': [1979], 'D.R.': [1980], 'Dermody': [1981], 'J.J.': [1982], 'Jha': [1983], 'K.K.': [1984], 'H.L.': [1986, 3929], '1994;': [1990], '14:': [1991], '1997-2003Crossref': [1992], '(266)': [1995], '32': [2003, 3915, 3966, 4019, 4092, 4137, 4210, 4304], '39': [2005, 3922, 3970, 4041, 4104, 4139, 4152, 4212, 4309], '°C,': [2006, 4093], 'indicated': [2008, 3547, 3580, 3618, 3665, 3711, 4246, 4341], 'text.': [2011], 'Transfections': [2012], 'done': [2014], 'using': [2015, 2293, 2323, 2328, 2425, 2528, 2967], 'FuGENE': [2016, 2086], '6': [2017], 'transfection': [2018, 2061], 'reagent': [2019], '(Roche': [2020], 'Applied': [2021], 'Science)': [2022], 'according': [2023], "manufacturer's": [2026], 'protocol': [2027], 'when': [2028, 3502, 3998, 4008, 4028], '∼60%': [2031], 'confluent.': [2032], 'Briefly,': [2033, 2889], 'transfected': [2036, 2892, 3092, 3361, 3542, 3640, 3706, 3756, 3810, 4188, 4288], '0.5-1.0': [2038], 'μg': [2039, 2048, 3721, 4198], 'FLAG': [2041, 2179, 2279, 2284, 2288, 2313, 2317, 2329, 2846, 2931, 2974, 3659, 3712, 3790, 3814, 3826, 3834], 'DNA': [2043, 2050, 2058, 2165, 2183, 2959, 2978, 3563, 3708, 3717, 3769, 3812, 4290], 'alone': [2044, 3771, 4030], '1.0': [2047], 'encoding': [2051, 2209, 2225, 2448, 3095, 3545, 3709, 3718, 3759, 3813, 4191, 4291], 'and/or': [2053], 'Myc-tagged': [2054, 2181], '(myc-Ub).': [2056], 'Total': [2057], 'each': [2060, 3801], 'equalized': [2063], 'empty': [2068], 'plasmid.': [2069], 'μl': [2071, 2084, 2559, 2618, 2642, 2651, 2672, 2756, 2762], 'antibiotic-free': [2075], 'mixed': [2081, 2097, 2612], '3': [2083, 2779], '6,': [2087], 'incubated': [2088, 2586, 2669], 'room': [2090, 2108, 2782], 'temperature': [2091, 3879], '5': [2093], 'min,': [2094], 'appropriate': [2100], 'DNAs.': [2101], 'Following': [2102], '30': [2103, 2590, 2617, 2671], 'min': [2104, 2591], 'incubation': [2106, 2906], 'temperature,': [2109, 2783], 'mixture': [2111], 'added': [2113], 'initiate': [2117], 'transfection.': [2118], 'lysates': [2120, 3109, 3642], 'harvested': [2122], '20-24': [2123, 2902], 'h': [2124, 2615, 2636, 2780, 2903, 4201], 'later.Plasmid': [2125], 'DNAs—FLAG-tagged': [2126], 'described': [2131, 2863], 'previously': [2132, 2864], '(32Gu': [2133], 'Rosenblum': [2137], 'Rubin': [2139], 'R.M.': [2140], '20:': [2147], '1243-1253Crossref': [2148], '(53)': [2151], 'Zhi-min': [2157], '(Harvard': [2159, 2221], 'School': [2160], 'Public': [2162], 'Health).': [2163], 'contains': [2166, 3266], 'sequences': [2169], 'cloned': [2170, 2269], 'BamHI': [2172, 2252, 2272], 'XbaI': [2174], 'sites': [2175, 2275], 'epitope.': [2180, 2280], '(33Ward': [2184], 'C.L.': [2185], 'Omura': [2186], 'Kopito': [2188, 2205], 'R.R.': [2189], '83:': [2192], '121-127Abstract': [2193], '(1127)': [2199], 'Ron': [2204], 'DNAs': [2208, 2224, 2244, 2447, 3094, 3544, 3758, 4190], 'untagged': [2210], 'mutants': [2212, 2282, 2311, 3323, 3335, 3390, 3405, 3457, 3696], 'V143A,': [2213, 3205, 3243, 3430, 3632], 'R248W,': [2214], 'H179E': [2216, 3207], 'Peter': [2219], 'Medical': [2222, 2239], 'School).': [2223, 2240], 'HA-tagged': [2229], 'C135Y': [2231, 2286, 2319, 3352, 3373, 3384, 3427, 3496, 3514, 3629, 3763, 3767, 3803, 3816, 3960, 4129, 4150, 4294, 4315, 4329, 4343], 'Steve': [2234], 'Grossman': [2235], 'Massachusetts': [2238], 'Untagged': [2241], 'amplified': [2246], 'PCR': [2248, 2424, 2527], 'contain': [2250], 'site': [2253, 2261, 2439, 2453, 2466, 2483, 2500], 'their': [2255, 2263, 2342, 3170, 3358, 3465], 'termini': [2257, 2265], 'EcoRI': [2260, 2274], 'V143A': [2290, 3164, 3355, 3376, 3388, 3635], 'generated': [2292, 2322, 2421, 2458], 'QuikChange': [2295, 2325], 'site-directed': [2296], 'mutagenesis': [2297, 2326], 'kit': [2298, 2327], '(Stratagene)': [2299], 'following': [2302, 2339, 2427, 2471, 2488, 2505], 'primer': [2303, 2428, 2531], 'complement:': [2306, 2431], '5′-GAGCTGAATGAGGCCGCAGAAGCCAAGGATGCCCAGGCTG-3′.': [2307], 'Lysine': [2308], 'arginine': [2310], 'WT': [2315, 4193], '(WT': [2331], 'C135Y)': [2333], 'template': [2336], 'primers': [2340, 2473, 2490, 2507], 'complements:': [2343], 'K372R,K373R': [2346], '5′-CAGCCACCTGAAGTCCAGAAGGGGTCAGTCTACCTCC-3′;': [2348], 'K370R': [2351], '5′-CACTCCAGCCACCTGAGGTCCAGAAGGGGTCAG-3′;': [2353], 'K381R,K382R': [2356], '5′-CTACCTCCCGCCATAGGAGGCTCATGTTCAAG-3′;': [2358], 'K386R': [2361], '5′-CTCATGTTCAGGACAGAAGG-3′;': [2363], 'K357R': [2366], '5′-GCCCAGGCTGGGAGGGAGCCAGGG-3′;': [2368], 'K351R': [2371], '5′-CCTTGGAACTCAGGGATGCCCAG-3′;': [2373], 'K319R,K320R,K321R': [2376], '5′-CCTCTCCCCAGCCAAGGAGGAGACCACTGGATGGAG-3′;': [2378], 'K305R': [2381], '5′-GGAGCACTAGGCGAGCACTG-3′;': [2383], 'K292R,K293R': [2386], '5′-CTCCGCAGGAGAGGGGAGCCTC-3′;': [2388], 'K164R': [2390], '5′-GCCATCTACAGGCAGTCACAGC-3′;': [2392], 'K139R': [2395], '5′-CAACTGGCCAGGACCTGCCCTG-3′;': [2397], 'K132R': [2400], '5′-GCCCTCAACAGGATGTTTTACC-3′;': [2402], 'K120R': [2405], '5′-GGGACAGCCAGGTCTGTGACTTG-3′;': [2407], 'K101R': [2410], '5′-CCTTCCCAGAGAACCTACCAG-3′;': [2412], 'K24R': [2416], '5′-GACCTATGGAGACTACTTCCTG-3′.': [2418], 'p53-(Δ101-195)': [2419], 'two-step': [2423, 2460], '5′-GTCCCTTCCCAGCGAGTGGAAGG-3′.DNAs': [2432], 'Encoding': [2433], 'TEV-cleavable': [2434], 'p53—The': [2435], 'TEV': [2436, 2450, 2465, 2482, 2499, 2540, 2698, 2718, 2736, 2758, 2764, 2776, 2801], 'protease': [2437, 2451, 2765, 2777], 'cleavage': [2438, 2452, 2802], '7': [2441], 'amino': [2442], 'acids': [2443], 'long': [2444], '(ENLYFQG).': [2445], 'different': [2455, 3104, 3178], 'positions': [2456], 'PCR.': [2461], 'To': [2462, 2479, 2496, 3342, 3943], 'introduce': [2463, 2480, 2497], 'position': [2468, 2485, 2502, 3733], '364,': [2469], 'two': [2472, 2489, 2506, 2917, 2993, 4252, 4348], 'used:': [2475, 2492, 2509], '5′-GGGAGCAGGGCTGAGAATCTCTACTTCCAGGGACACTCCAGCCA-3′': [2476], '5′-GTGGCTGGAGTGTCCCTGGAAGTAGAGATTCTCAGCCCTGCTCCC-3′.': [2478], '294,': [2486], '5′-CGCAAGAAAGGGGAGAATCTCTACTTCCAGGGAGAGCCTCACCAC-3′': [2493], '5′-GTGGTGAGGCTCTCCCTGGAAGTAGAGATTCTCCCCTTTCTTGCG-3′.': [2495], '290,': [2503], '5′-GGAAGAGAATCTCTACTTCCAGGGACGCAAGAAAGGG-3′': [2510], '5′-CCCTTTCTTGCGTCCCTGGAAGTAGAGATTCTCTTCC-3′.': [2512], 'An': [2513], 'HA': [2514, 2535], 'tag': [2515, 2536], 'introduced': [2517], '(TEV': [2524], '290)': [2525], 'encodes': [2533], '5′-CGGAATTCCTCAAGCGTAATCTGGAACATCGTATGGGTACATGTCTGAGTCAGGCCCTTC-3′.Immunoprecipitations,': [2537], 'Immunoblotting,': [2538], 'Cleavage—To': [2541], 'harvest': [2542], 'lysates,': [2544], 'rinsed': [2547], '2': [2549, 2641], 'ml': [2550, 2707, 2727], 'phosphate-buffered': [2552, 2730], 'saline': [2553, 2731], 'scraped': [2556], '500': [2558], 'lysis': [2561, 2710], 'buffer': [2562, 2711, 2737], '(50': [2563, 2738], 'mm': [2564, 2569, 2739, 2744, 2747], 'Tris,': [2565, 2740], 'pH': [2566, 2741], '7.5,': [2567, 2742], '150': [2568], 'NaCl,': [2570], '0.5%': [2571], 'Nonidet': [2572], 'P-40,': [2573], 'phenylmethylsulfonyl': [2574], 'fluoride,': [2575], 'leupeptin)': [2576], 'transferred': [2578, 2816], 'microcentrifuge': [2580], 'tubes.': [2581], 'ice': [2588], 'occasional': [2593], 'vortexing': [2594], 'spun': [2596], '4': [2598, 2638], '14,000': [2601], 'rpm': [2602], 'microcentrifuge.': [2605], 'For': [2606, 2693, 2717], 'immunoprecipitations,': [2607], 'resulting': [2609], 'supernatant': [2610, 2628, 2798], '1': [2614, 2678, 2706, 2726, 2746, 2761], 'A-agarose': [2621, 2675], 'beads': [2622, 2676, 2682, 2701, 2721, 2750, 2769, 2786], 'pre-clear': [2624, 2631], 'lysate.': [2626], 'immunoprecipitated': [2633, 3112, 3130, 3778, 3823], '12-15': [2635], 'anti-FLAG': [2644, 2937, 3559, 3730, 4324], 'polyclonal': [2645, 2833, 2939, 3827, 4325], '(F-7145,': [2647], 'Sigma)': [2648], '1.75': [2650], '(pAb1620,': [2657], 'Ab-5,': [2658], 'Calbiochem)': [2659], '(pAb240,': [2664], 'Ab-3,': [2665], 'Calbiochem).': [2666], 'Immunoprecipitations': [2667], 'h,': [2679], 'isolated': [2684], 'centrifugation': [2686, 2790], '10': [2688, 2715, 2792, 2808], 's': [2689, 2793], '13,000': [2691, 2795], 'rpm.': [2692, 2796], 'direct': [2694], 'immunoblot': [2695], 'analysis': [2696], 'without': [2697], 'cleavage,': [2699, 2719], 'washed': [2703, 2723], 'twice': [2704, 2724], 'ice-cold': [2709, 2729, 2735], 'boiled': [2713, 2806], 'min.': [2716, 2809, 2912], 'once': [2733], '0.5': [2743], 'EDTA,': [2745], 'dithiothreitol).': [2748], 'resuspended': [2753], '25': [2755], 'buffer,': [2759], 'added.': [2767], 'rotated': [2771], 'presence': [2774, 2922], 'pelleted': [2788], 'contained': [2799], 'products': [2803], 'Products': [2810], 'resolved': [2812], 'SDS-PAGE': [2814], 'polyvinylidene': [2818], 'difluoride': [2819], 'membranes': [2820], 'immunoblotting.': [2822], 'Antibodies': [2823], 'immunoblotting': [2826, 3122, 3656, 3727, 3786, 3831], 'detect': [2828], 'included': [2830], 'sheep': [2832], 'Ab-7': [2835], '(Oncogene': [2836, 2842], 'Science),': [2837, 2843], 'monoclonal': [2838, 2847, 3660, 3791, 3835], '1801': [2841], 'Ab-5': [2849], '(Sigma).': [2850], 'SMP-14': [2854], '(Santa': [2855], 'Cruz': [2856], 'Biotechnology).Immunofluorescence—Immunofluorescence': [2857], 'staining': [2858, 2983, 3556, 3568, 4223, 4321], 'carried': [2860], 'out': [2861], '(34Inoue': [2865], 'Stuart': [2867], 'Leno': [2869], '277:': [2877], '15053-15060Abstract': [2878], 'glass': [2894], 'coverslips': [2895], '6-well': [2897], 'dishes.': [2898], 'Cells': [2899, 2913, 2964, 4268], 'fixed': [2901], 'later': [2904], '4%': [2908], 'paraformaldehyde': [2909], '45': [2911], 'blocked': [2915], '5-min': [2918], 'incubations': [2919], '1%': [2924], 'albumin,': [2927], '0.1%': [2928], 'Triton': [2929], 'X-100.': [2930], 'detected': [2934], 'F-7145': [2941], '(Sigma)': [2942], 'antibody,': [2946, 3783, 3828, 4326], 'rhodamine-conjugated': [2949], 'anti-rabbit': [2950], '(The': [2952], 'Jackson': [2953], 'Laboratory)': [2954], 'secondary': [2957], 'antibody.': [2958, 3661, 3731, 3792, 3836], 'stained': [2961], 'DAPI.': [2963], 'visualized': [2966, 3565], 'fluorescence': [2969], 'microscope.': [2970], 'Merged': [2971, 3570], 'images': [2972], 'showing': [2973], 'localization,': [2976, 3201], 'stainings': [2979], 'obtained.': [2981], 'pattern': [2984], 'scored': [2988, 3584], '100-150': [2990], 'three': [2995], 'separate': [2996, 4253, 4349], 'experiments.RESULTSMutant': [2997], 'Are': [2999], 'Cytoplasmic': [3000], 'Dependent': [3002], 'Their': [3004], 'Intact': [3009], 'Pathway—Cancer-associated': [3011], 'occur': [3015], 'alter': [3024], 'assessing': [3040], 'pAb1620': [3046], '(wild-type': [3047], 'specific)': [3048, 3052], 'pAb240': [3050], '(mutant': [3051], 'our': [3084], 'first': [3085], 'experiment,': [3086], 'Saos-2': [3087], 'null)': [3090], 'FLAG-tagged': [3096, 3548, 3671, 4192, 4292], 'harbored': [3103], 'cancer-associated': [3105], 'mutations.': [3106], 'Transfected': [3107], 'antibodies,': [3119, 3653], 'followed': [3120, 3654, 3784, 3829], 'amount': [3127], 'mutant-specific': [3135, 3439], 'indication': [3139], 'As': [3143, 3184, 3363, 3988], 'shown': [3144, 3185, 3364, 3989], 'Fig.': [3146, 3187, 3366, 3991], '1C,': [3147], '(WT)': [3149], 'R248W': [3153, 3196], 'mostly': [3156, 3167, 3199, 3238, 3590, 3602, 3996, 4086, 4132], 'C135Y,': [3161, 3204, 3244, 3627, 3761], 'H179E,': [3162], 'all': [3166], 'Next,': [3172], 'immunofluorescence': [3182, 3555, 4222, 4320], 'staining.': [3183], '1,': [3188], 'A': [3189, 3368], 'B,': [3191, 3370, 3576, 3753, 4281], 'whereas': [3202, 3381], 'throughout': [3209], 'expressed.': [3221], 'correlation': [3226], 'between': [3227], 'Specifically,': [3234], '(such': [3241, 3262], 'H179E)': [3246], 'localize': [3247], 'R248W).Wild-type': [3264], 'reasoned': [3315], 'if': [3317], 'involves': [3324, 3477], 'export,': [3326, 3956], 'would': [3332], 'cause': [3333], 'assume': [3337], 'localization.': [3341, 4248, 4344], 'test': [3343, 3944], 'this,': [3344], 'mutated': [3346], 'cells.': [3362, 4267], '2,': [3367], 'nonmutated': [3371], 'largely': [3378, 4026], 'localizations,': [3380], 're-localized': [3392, 4002], 'completely': [3394, 4274], 'nucleus.': [3397], 'indicates': [3399, 3675, 4109], 'requires': [3406, 3530, 3856, 4174], '(Fig.': [3447, 3506, 4106], '2C).': [3448], 'suggests': [3450], 'accumulation': [3453, 3511, 4147], 'due': [3460, 3518], 'total,': [3468], 'should': [3486], 'noted': [3489], 'still': [3498], 'co-expressed': [3503, 4009, 4230], 'myc-Ub': [3505, 3719, 3751, 3774], '4B),': [3507], 'indicating': [3508, 4144], 'ubiquitinated.FIGURE': [3524], '2Cytoplasmic': [3525], 'A,': [3538, 3702, 4179], '(red)': [3561], 'DAPI': [3567], '(blue).': [3569], 'representative': [3572], 'pictures': [3573], 'shown.': [3575, 4256], 'only': [3588, 4155, 4261], '(N,': [3592], '>': [3594, 3608], 'C)': [3595], 'equal': [3598], '(N': [3604], '=': [3605], 'C,': [3606, 3623, 3805], 'N).': [3609], 'graph': [3611, 4239, 4334], 'shows': [3612, 4240, 4335], 'percent': [3614, 4242, 4337], '(±': [3621], 'S.E.).': [3622], 'immunoprecipitation': [3644], '(w)': [3648], '(m)': [3651], 'upper': [3663], 'band': [3664], 'arrow': [3668], 'Ab': [3674], 'detection': [3676], 'heavy': [3680], 'chain': [3681], 'immunoprecipitation.View': [3685], 'Large': [3686, 3843, 4353], 'Image': [3687, 3844], 'Figure': [3688, 3845], 'ViewerDownload': [3689, 3846], 'Hi-res': [3690, 3847], 'image': [3691, 3848], 'Download': [3692, 3849], '(PPT)FIGURE': [3693], '4Cancer-derived': [3694], 'display': [3697], 'alone,': [3714, 4000], '(1': [3720, 4197, 4295], 'each).': [3722, 4199], 'Lysates': [3723, 3776, 3821], 'examined': [3725], 'nonubiquitinated': [3735], 'indicated.': [3738, 3820], 'Arrows': [3739], '(right)': [3740], 'indicate': [3741, 3839], 'ubiquitin-modified': [3742, 3798, 3840], 'forms': [3743, 3799], 'evident': [3749], 'co-expression.': [3752], 'Δ42N,': [3764], 'DNA.': [3775], '(IP)': [3779], 'anti-Myc': [3782], '(IB)': [3787], 'ladder': [3794], 'bands': [3796], 'DKO': [3807], 'myc-Ub,': [3818], 'arrows': [3838], 'C135Y.View': [3842], '(PPT)MDM2-dependent': [3850], 'Support': [3861], 'comes': [3864], 'nonpermissive': [3878, 3969], '(15Boyd': [3883, 4065], 'enzyme.': [3908], 'maintain': [3911], 'lose': [3918], '(35Zeng': [3924], 'G.C.': [3925], 'Donegan': [3926], 'Hand': [3930], '1815-1822Crossref': [3937], '(16)': [3940], 'whether': [3945], '°C.': [3971, 4020], 'temperatures': [3981], 'control': [3984], 'experiment.': [3987], '3A,': [3992], '(was': [4006], 'exported)': [4007], 'contrast,': [4022], 'remained': [4025], 'grown': [4039, 4183], 'consistent': [4049], 'previous': [4051], '(C135Y)': [4084, 4116], 'accumulated': [4096], '3B).': [4107], 'depends,': [4118], 'part,': [4122], 'cells,': [4143], 'seen': [4156], '(ts-20)': [4159], 'where': [4160], 'elevated': [4167], 'temperature.FIGURE': [4168], '3Nuclear': [4169], 'system.': [4178], '3-4': [4200], 'after': [4202], 'transfection,': [4203], 'switched': [4207], '20': [4215, 4312], 'h.': [4216, 4313], 'scored.': [4237, 4332], 'Average': [4249, 4345], 'experiments': [4254, 4350], 'excluded': [4277], 'analysis.': [4280], 'μg).': [4296], 'shifted': [4307], 'shown.View': [4352]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051409222', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T02:30:03.994365', 'created_date': '2016-06-24'}