Abstract: The central problem of early development of the nervous system is how different regions become determined and morphological and histological patterns are formed. Regional determination occurs as a result of cell lineage, cell position and induction1–3. Here we consider the role of cell lineage in pattern formation in the vertebrate central nervous system. The questions we ask are how lineages become different according to the positions of ancestral cells in the early embryo, how cell fates become restricted by their lineage from different ancestral cells, and how the restrictions are expressed during formation of morphological and histological patterns in the central nervous system. Clonal analysis of the frog embryo is starting to yield answers to those questions.
Publication Year: 1985
Publication Date: 1985-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 13
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