Publication Information

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'damage': [18, 252, 2532, 2793], 'tissues': [19, 253, 3652, 3669], 'and': [20, 81, 126, 128, 136, 141, 145, 150, 160, 175, 199, 204, 207, 231, 254, 315, 360, 362, 370, 375, 379, 384, 394, 409, 433, 438, 441, 465, 578, 585, 592, 600, 627, 630, 638, 658, 665, 672, 706, 711, 722, 738, 747, 805, 810, 908, 930, 981, 997, 1046, 1053, 1080, 1082, 1091, 1138, 1148, 1311, 1562, 1571, 1601, 1685, 1693, 1702, 1712, 1734, 1812, 1841, 1904, 1963, 2044, 2099, 2105, 2112, 2198, 2265, 2346, 2369, 2386, 2417, 2440, 2474, 2481, 2483, 2496, 2541, 2553, 2615, 2641, 2654, 2657, 2678, 2699, 2773, 2783, 2794, 2820, 2847, 2852, 2892, 2932, 2939, 2947, 2984, 2997, 3010, 3029, 3043, 3073, 3109, 3142, 3189, 3201, 3217, 3237, 3243, 3250, 3281, 3326, 3333, 3360, 3404, 3438, 3453, 3484, 3501, 3520, 3555, 3625, 3634, 3641, 3650, 3662, 3765, 3772, 3792, 3830, 3851, 3873, 3901, 3927, 3936, 4131], 'cells': [21, 255, 2996, 3042], 'by': [22, 119, 256, 353, 686, 1103, 1120, 1530, 1547, 1677, 1824, 1858, 2016, 2459, 2520, 2603, 2718, 2763, 2780, 3000, 3015, 3046, 3132, 3167, 3224, 3310, 3569, 3616, 3655, 3692, 3746, 3794, 3972], 'oxidizing': [23, 257, 2545], 'virtually': [24, 258], 'all': [25, 259, 649, 3666], 'biomolecules.': [27, 261], 'Peroxiredoxin': [28, 262], '6': [29, 263], '(PRDX6)': [30, 264], '(also': [31, 265], 'called': [32, 266], 'antioxidant': [33, 224, 232, 267, 458, 466, 484, 528, 687, 725, 762, 793, 893, 895, 899, 2644, 2807, 2846, 2853, 3883, 3990], 'protein': [34, 58, 177, 268, 292, 411, 485, 529, 900, 2477, 2484], '2,': [35, 269, 3249], 'or': [36, 270, 1722, 3427, 3749], 'AOP2)': [37, 271], 'is': [38, 48, 220, 272, 282, 454, 683, 764, 797, 982, 998, 1336, 1626, 1675, 1819, 1997, 2013, 2034, 2040, 2077, 2564, 2577, 2669, 2680, 2710, 2753, 3270, 3295], 'a': [39, 221, 273, 455, 775, 973, 1008, 1321, 1611, 1639, 1646, 1853, 1994, 2378, 2382, 2425, 2623, 2711, 2795, 2893, 2919, 3032, 3252, 3258, 3288, 3334, 3551, 3558, 3573, 3718, 3773, 3849, 3909, 4062, 4107], 'novel': [40, 274], 'peroxiredoxin': [41, 275, 766, 877, 920, 940], 'family': [42, 276, 760, 878], 'member': [43, 277], 'whose': [44, 278], 'function': [45, 279, 2633], 'vivo': [47, 216, 281, 450, 2723, 2843, 3424], 'unknown.': [49, 283], 'Through': [50, 284], 'immunohistochemistry,': [51, 127, 285, 361], 'we': [52, 109, 286, 343, 1063, 2648, 3416], 'have': [53, 287, 1320, 1610, 2362, 2542], 'determined': [54, 288], 'that': [55, 99, 218, 225, 289, 333, 452, 459, 1803, 2568, 2683, 2714, 2767, 4123], 'the': [56, 116, 130, 186, 290, 350, 364, 420, 614, 650, 765, 915, 917, 927, 933, 987, 1057, 1065, 1070, 1104, 1121, 1300, 1340, 1531, 1548, 1590, 1630, 1651, 1655, 1671, 1682, 1698, 1804, 1820, 1848, 1990, 2004, 2096, 2268, 2317, 2466, 2492, 2497, 2527, 2538, 2543, 2569, 2578, 2631, 2688, 2775, 2812, 2863, 2897, 2904, 2910, 2925, 2954, 2967, 2987, 3011, 3019, 3021, 3053, 3061, 3083, 3098, 3110, 3116, 3121, 3127, 3145, 3165, 3202, 3205, 3215, 3262, 3267, 3277, 3292, 3351, 3365, 3375, 3390, 3393, 3397, 3401, 3435, 3447, 3504, 3537, 3583, 3591, 3594, 3597, 3620, 3626, 3631, 3667, 3673, 3681, 3722, 3804, 3818, 3846, 3863, 3867, 3882, 3919, 3959, 3965, 3989, 4116, 4120], 'PRDX6': [57, 219, 291, 453, 984, 1045, 1695, 2769, 2840, 4074], 'was': [59, 72, 86, 293, 306, 320, 941, 994, 1004, 1042, 1297, 1587, 2868, 2888, 2906, 2916, 2928, 2945, 2964, 2979, 3008, 3013, 3024, 3055, 3080, 3093, 3104, 3113, 3138, 3444, 3463, 3496, 3567, 3612, 3653, 3670, 3685, 3690, 3715, 3736, 3801, 3860, 3916, 3956, 4075, 4104, 4113], 'widely': [60, 294, 2670], 'expressed': [61, 88, 295, 322, 1139, 1563], 'every': [63, 90, 297, 324], 'tissue': [64, 91, 173, 298, 325, 407, 2785, 2792], 'examined,': [65, 299], 'most': [66, 300, 2539, 2570], 'abundantly': [67, 301], 'epithelial': [69, 303], 'cells.': [70, 304], 'It': [71, 305, 1801, 2421, 2709], 'found': [73, 307], 'cytosol,': [75, 309], 'but': [76, 310], 'not': [77, 311, 1967, 3271], 'membranes,': [79, 313], 'organelles,': [80, 314], 'nuclei': [82, 316], 'fractions.': [83, 317], 'Prdx6': [84, 97, 318, 331, 2866, 3206, 3219, 3264, 3377, 3538, 3723], 'mRNA': [85, 187, 319, 421, 3963], 'also': [87, 321, 769, 2069, 2422, 2815], 'examined.': [92, 326], 'The': [93, 327, 676, 792, 1306, 1596, 1708, 1839, 2454, 2809, 2886, 2914, 2971, 2989, 3003, 3035, 3057, 3089, 3101, 3134, 3226, 3514, 3601, 3610, 3712, 3732, 3782, 3828, 3878, 4099], 'widespread': [94, 328], 'expression': [95, 188, 329, 422], 'suggested': [98, 332], 'its': [100, 334, 800, 2375, 2617], 'functions': [101, 226, 335, 460, 2841], 'were': [102, 182, 336, 416, 879, 2821, 2992, 3038, 3130, 3162, 3178, 3181, 3196, 3208, 3222, 3299, 3355, 3368, 3388, 3392, 3414, 3518, 3533, 3545, 3604, 3628, 3785, 3815, 3897, 3944, 3970, 3982], 'quite': [103, 337], 'important.': [104, 338], 'To': [105, 339, 1050, 2629, 3017, 3343, 3843], 'determine': [106, 340], 'functions,': [108, 342, 886], 'generated': [110, 344, 2649, 3081, 3568, 4105], 'Prdx6-targeted': [111, 345, 2650, 2857, 3345, 3353, 3366, 3381, 3407], 'mutant': [112, 346, 2651, 3382, 3408, 3599], '(Prdx6–/–)': [113, 347, 2652], 'mice,': [114, 348, 1725, 3359], 'confirmed': [115, 349], 'gene': [117, 351, 625, 1083, 1296, 1586, 2867, 2905, 3265, 3378], 'disruption': [118, 352], 'Southern': [120, 354, 3168, 3530], 'blots,': [121, 125, 355, 359], 'PCR,': [122, 356], 'RT-PCR,': [123, 357], 'Western': [124, 358], 'compared': [129, 363], 'effects': [131, 365], 'paraquat,': [133, 367], 't-butyl': [137, 371], 'hydroperoxide': [138, 372, 807, 2200], 'on': [139, 148, 373, 382, 1107, 1313, 1534, 1603, 1909, 3347, 3384, 3410, 3550, 3840], 'Prdx6–/–': [140, 149, 153, 164, 203, 374, 383, 387, 398, 437, 2787, 2813], 'wild-type': [142, 376, 2658, 3394, 3419, 3428], '(Prdx6+/+)': [143, 377, 2660], 'macrophages,': [144, 378], 'paraquat': [147, 381, 2725, 3425], 'Prdx6+/+': [151, 205, 385, 439], 'mice.': [152, 386], 'macrophages': [154, 388, 2810], 'had': [155, 166, 389, 400, 2789, 2816], 'higher': [156, 176, 390, 410, 2797], 'peroxide': [158, 392, 572], 'levels,': [159, 393], 'lower': [161, 168, 395, 402], 'survival': [162, 169, 396, 403], 'rates;': [163, 397], 'mice': [165, 206, 399, 440, 2653, 3188, 3195, 3212, 3372, 3383, 3409, 3422], 'significantly': [167, 401, 2796], 'rates,': [170, 404], 'more': [171, 405, 2368, 2370, 2790, 2817, 2822], 'severe': [172, 406, 2791], 'damage,': [174, 408], 'oxidation': [178, 412], 'levels.': [179, 413, 2523], 'Additionally,': [180, 414], 'there': [181, 415, 1318, 1608, 2679], 'no': [183, 417], 'differences': [184, 418], 'levels': [189, 423, 2488], 'other': [191, 229, 425, 463, 2005, 2429, 2805, 2850, 3668], 'peroxiredoxins,': [192, 426, 1072], 'glutathione': [193, 427, 495, 539, 733, 2113], 'peroxidases,': [194, 428], 'catalase,': [195, 429], 'superoxide': [196, 430, 502, 546, 565, 728], 'dismutases,': [197, 431], 'thioredoxins,': [198, 432], 'glutaredoxins': [200, 434], 'between': [201, 435, 2042], 'normal': [202, 436], 'those': [208, 442, 3361], 'injected': [209, 443], 'with': [210, 444, 1094, 1847, 2001, 2616, 2661, 2730, 2890, 2930, 2950, 2981, 2986, 3027, 3031, 3095, 3107, 3140, 3283, 3487, 3498, 3508, 3547, 3614, 3672, 3699, 3725, 3899], 'paraquat.': [211, 445], 'Our': [212, 446, 2828], 'study': [213, 447, 2630, 2829], 'provides': [214, 448, 2830], 'evidence': [217, 451, 2682, 2831], 'unique': [222, 456, 2618, 3850], 'non-redundant': [223, 457], 'independently': [227, 461], 'peroxiredoxins': [230, 464, 1093, 2851], 'proteins.': [233, 467], 'Living': [468], 'organisms': [469], 'produce': [470, 2673, 2733], 'reactive': [471, 480, 524, 593], '(ROS),': [474], '1The': [475, 519], 'abbreviations': [476, 520], 'used': [477, 521, 1338, 1628, 2671, 3417, 3534, 3716, 3992], 'are:': [478, 522], 'ROS,': [479, 523, 664], 'species;': [482, 526], 'AOP2,': [483, 527, 996], '2;': [486, 530], 'CAT,': [487, 531], 'catalase;': [488, 532], 'DCFH-DA,': [489, 533], '2′,7′-dichlorofluorescein': [490, 534], 'diacetate;': [491, 535], 'GLRX,': [492, 536], 'glutaredoxin;': [493, 537], 'GPX,': [494, 538], 'peroxidase;': [496, 540], 'PQ2+,': [497, 541], 'paraquat;': [498, 542], 'PRDX,': [499, 543, 1691, 2602], 'peroxiredoxin;': [500, 544], 'SOD,': [501, 545], 'dismutase;': [503, 547], 'TSA,': [504, 548], 'thio-specific': [505, 549, 892], 'antioxidant;': [506, 550], 'TXN,': [507, 551], 'thioredoxin;': [508, 552], 'DMEM,': [509, 553], "Dulbecco's": [510, 554], 'modified': [511, 555, 2441], "Eagle's": [512, 556], 'medium;': [513, 557], 'MTT,': [514, 558], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [515, 559], 'bromide;': [516, 560], 'Ab,': [517, 561], 'antibody.': [518, 562], 'such': [563, 596, 612, 653, 697, 715, 727, 890, 2389, 2431], 'as': [564, 597, 613, 654, 698, 716, 771, 891, 1140, 1316, 1327, 1339, 1564, 1606, 1617, 1629, 1845, 1856, 2102, 2114, 2377, 2390, 2424, 2432, 2472, 2643, 2844, 2870, 3300, 3687, 3717, 3893], '(': [566, 576], 'O2.−),': [567], 'hydroxyl': [568, 2534], 'radicals': [569, 575, 580, 2535], '(OH•),': [570], '(H2O2),': [573], 'peroxyl': [574], 'RO2.)': [577], 'alkoxyl': [579], '(RO•)': [581], 'under': [582, 2833], 'physiological': [583], 'conditions': [584, 2834, 3298], 'response': [587], 'to': [588, 799, 802, 808, 882, 972, 986, 1054, 1658, 1687, 1727, 1807, 1814, 2007, 2465, 2531, 2566, 2672, 2732, 2755, 2824, 2849, 2952, 2961, 3198, 3210, 3357, 3370, 3535, 3557, 3578, 3720, 3958, 4115, 4127], 'external': [589], 'stimuli.': [590], 'ROS': [591, 682, 2528, 2675, 2684], 'nitrogen': [594], 'ONOO–,': [598], 'NO•,': [599], 'NO2.': [601], 'employed': [603], 'living': [605], 'systems': [606], 'for': [607, 926, 1150, 1573, 2381, 2428, 2574, 2687, 3164, 3214, 3228, 3364, 3374, 3833, 3881, 3924, 3933, 3939], 'many': [608, 617, 2525], 'biologically': [609], 'useful': [610], 'purposes,': [611], 'functioning': [615], 'enzymes,': [618], 'killing': [619], 'mechanism': [620, 2573], 'phagocytes,': [622], 'regulation': [623], 'expression,': [626], 'cell': [628, 670, 674, 2613, 2826, 3160], 'growth': [629, 2387, 2393, 2397, 2406, 2412, 3078], 'proliferation': [631], '(1Halliwell': [632, 741, 2547, 2693], 'B.': [633, 742, 781, 1015, 1164, 1398, 1490, 1518, 1738, 1981, 2057, 2320, 2338, 2548, 2694, 2880, 4087, 4091], 'Free': [634, 743, 2549, 2695], 'Radicals': [635, 744, 2550, 2696], 'Biology': [637, 746, 2552, 2698], 'Medicine.': [639, 748, 2554, 2700], '3rd.': [640, 749, 2555, 2701], 'Ed.': [641, 750, 2556, 2702], 'Oxford': [642, 751, 2557, 2703], 'University': [643, 752, 2558, 2704], 'Press,': [644, 753, 2559, 2705], 'New': [645, 754, 2560, 2706], 'York1999Google': [646, 755, 2561, 2707], 'Scholar).': [647, 756, 791, 825, 873, 1038, 1800, 1838, 1960, 1988, 2030, 2064, 2091, 2192, 2315, 2453, 2510, 2562, 2708, 2748, 2885, 4098], 'biomolecules,': [652, 2533], 'DNA,': [655], 'lipids,': [656], 'proteins,': [657], 'carbohydrates': [659], 'potential': [661, 2632, 3856], 'targets': [662], 'oxidative': [667, 2611, 2639, 2663, 2837], 'stress': [668, 2640], 'causes': [669], 'injury': [671], 'ultimately': [673], 'death.': [675, 2827], 'beneficial': [677], 'versus': [678], 'damaging': [679, 2674, 2689], 'effect': [680, 2690], 'tightly': [684], 'controlled': [685], 'defense': [688, 2645], 'systems,': [689], 'which': [690, 1674, 2012, 2727, 2934, 3221, 3588], 'comprise:': [691], '1)': [692, 1718, 3314, 3753], 'low': [693, 2442], 'molecular': [694], 'mass': [695], 'agents': [696], 'polyphenols,': [699], 'tocopherols,': [700], 'carotenoids,': [701], 'glutathione,': [702], 'bilirubin,': [703], 'ubiquinol,': [704], 'melatonin,': [705], 'lipoic': [707], 'acid;': [708], '2)': [709, 1732, 3320, 3759], 'iron': [710], 'copper': [712], 'sequestration': [713], 'proteins': [714, 1644], 'transferrin,': [717], 'lactoferrin,': [718], 'ferritin,': [719], 'hemopexin,': [720], 'albumin,': [721], 'caeruloplasmin;': [723], '3)': [724, 1735, 3327, 3766], 'enzymes': [726, 763, 3884, 3991], 'dismutases': [729], '(SOD),': [730], 'catalases': [731], '(CAT),': [732], 'peroxidases': [734, 773], '(GPX),': [735], 'thioredoxin': [736, 772, 2017, 2097], '(TXN),': [737], 'glutaredoxin': [739], '(GLRX)': [740], 'A': [757, 2957, 3049, 3172, 3564], 'relatively': [758], 'new': [759, 1640, 4063], '(PRDX)': [767], 'family,': [768], 'known': [770], '(see': [774], 'recent': [776], 'review,': [777], 'see': [778], 'Ref.': [779], '2Hofmann': [780], 'Hecht': [782], 'H.J.': [783, 837, 1888, 2158], 'Flohe': [784], 'L.': [785], 'Biol.': [786, 820, 1033, 1202, 1354, 1416, 1435, 1479, 1756, 1775, 1833, 1899, 1943, 1984, 2025, 2060, 2086, 2124, 2143, 2164, 2208, 2225, 2242, 2259, 2310], 'Chem.': [787, 821, 1034, 1203, 1355, 1417, 1436, 1480, 1757, 1776, 1834, 2026, 2087, 2125, 2144, 2165, 2209, 2226, 2243, 2260, 2311], '2002;': [788, 1957, 2189, 2295, 2312], '383:': [789], '347-364Google': [790], 'property': [794], 'PRDX': [796, 1643, 1811, 1817, 1996, 2073, 2107, 2194, 2513, 2636], 'attributed': [798], 'ability': [801, 2546], 'reduce': [803, 2267, 2774], 'H2O2': [804, 1825, 2197, 2365, 2457, 2522, 2592, 2762, 2772], 'alkyl': [806], 'water': [809], 'alcohol,': [811], 'respectively': [812], '(3Kang': [813, 1826, 2018, 2079, 2117, 2201], 'S.W.': [814, 839, 861, 956, 1425, 1446, 1765, 1786, 1827, 1890, 2019, 2080, 2118, 2133, 2202], 'Baines': [815, 1428, 1768, 1828, 2020, 2081, 2119, 2136, 2203], 'I.C.': [816, 1429, 1769, 1829, 2021, 2082, 2120, 2137, 2204], 'Rhee': [817, 840, 852, 947, 1250, 1349, 1432, 1449, 1772, 1789, 1830, 1893, 2022, 2083, 2121, 2140, 2205], 'S.G.': [818, 841, 853, 948, 1251, 1350, 1433, 1450, 1773, 1790, 1831, 1894, 2023, 2084, 2122, 2141, 2206, 2446, 2503], 'J.': [819, 1032, 1201, 1286, 1353, 1367, 1385, 1415, 1434, 1478, 1755, 1774, 1832, 1941, 1982, 2024, 2058, 2085, 2123, 2142, 2163, 2207, 2224, 2241, 2258, 2309, 2330, 4093], '1998;': [822, 1520, 1835, 1900, 2027, 2088, 2126, 2210, 2588, 2882], '273:': [823, 1836, 2028, 2089, 2127, 2211], '6303-6311Google': [824, 1837, 2029, 2090, 2128, 2212], 'There': [826, 2563], 'six': [828, 1071, 1816], 'subgroups': [829], 'PRDXs': [831, 1843], 'mammals': [833], '(4Chae': [834], 'H.Z.': [835, 855, 950, 1241, 1348, 2162], 'Kim': [836, 1178, 1233, 1426, 1443, 1766, 1783, 2134, 2153, 2157, 2159, 2303], 'Kang': [838, 860, 955, 1424, 1445, 1764, 1785, 1889, 2132], 'Diabetes': [842], 'Res.': [843, 1455, 1795, 2743], 'Clin.': [844], 'Pract.': [845], '1999;': [846, 870, 965, 1035, 1376, 1418, 1481, 1758, 1883, 2261, 2450, 2507], '45:': [847], '101-112Google': [848], 'Scholar,': [849, 1171, 1184, 1207, 1239, 1276, 1359, 1379, 1421, 1440, 1460, 1497, 1510, 1761, 1780, 1886, 1930, 1947, 2129, 2148, 2169, 2213, 2230, 2247, 2298, 2334], '5Lyu': [850], 'M.S.': [851, 946, 1423, 1763, 1932, 2131], 'Chae': [854, 949, 1347, 2161], 'Lee': [856, 951, 1430, 1447, 1770, 1787, 2138], 'T.H.': [857, 952, 1431, 1442, 1771, 1782, 2139], 'Adamson': [858, 953], 'M.C.': [859, 954], 'Jin': [862, 957], 'D.Y.': [863, 958, 1346, 1452, 1792], 'Jeang': [864, 959, 1351], 'K.T.': [865, 960, 1352], 'Kozak': [866, 961], 'C.A.': [867, 962], 'Mamm.': [868, 963], 'Genome.': [869, 964], '10:': [871, 966], '1017-1019Google': [872, 967], 'Historically,': [874], 'members': [875, 921], 'named': [880, 943, 983, 995, 1000, 1006, 1044], 'according': [881, 971, 985], 'their': [883, 1075, 1078, 1905], 'first': [884, 3025], 'discovered': [885], 'resulting': [887, 3713], 'names': [889], '(TSA),': [894], 'enzyme': [896], 'B166': [897], '(AOEB166),': [898], '2': [901, 2938, 3694], '(AOP2),': [902], 'acidic': [903], 'Ca2+-independent': [904], 'phospholipase': [905, 2479], 'A2': [906, 2480], '(aiPLA2),': [907], 'natural': [909], 'killer': [910], 'enhancing': [911], 'factor': [912, 2402, 2407], '(NKEF).': [913], 'Over': [914], 'years,': [916], 'nomenclature': [918, 975, 989, 1068, 1101, 1118, 1528, 1545], 'has': [922, 1012, 2366, 2462], 'become': [923], 'confusing,': [924], 'AOEB166': [928, 1003], 'group': [929], '1-Cys': [931, 939, 1706, 1842, 2072, 2106, 2193, 2512, 2601, 2619, 2635], 'peroxiredoxin,': [932], 'subject': [934], 'this': [936, 1061, 1295, 1585, 3255], 'report.': [937], 'Mouse': [938, 1134, 1302, 1330, 1558, 1592, 1620, 3869], 'initially': [942, 1005, 1043], 'AOP2': [944, 978], '(5Lyu': [945], 'Scholar),': [968, 1903], 'renamed': [969], 'PRDX5': [970, 1965, 2033], 'later': [974], 'standard,': [976], 're-named': [977, 1048], 'again': [979], 'later,': [980], 'current': [988, 1066], 'standard.': [990], 'Its': [991, 1039], 'human': [992, 1092, 1694, 1713, 1964, 2032, 2318], 'counterpart': [993, 1041], 'currently': [999], 'PRDX6.': [1001], 'Mammalian': [1002], 'PRDXV,': [1007], 'name': [1009], 'it': [1010, 1999, 2757, 4124], 'still': [1011], 'today': [1013], '(6Knoops': [1014, 1737], 'Clippe': [1016, 1399, 1739, 1974, 2050], 'A.': [1017, 1031, 1179, 1217, 1234, 1258, 1361, 1363, 1381, 1383, 1400, 1414, 1740, 1754, 1882, 1975, 1979, 2051, 2055, 2188, 2234, 2294], 'Bogard': [1018, 1401, 1741], 'C.': [1019, 1025, 1402, 1408, 1742, 1748, 1973, 2049, 2217, 2251], 'Arsalane': [1020, 1403, 1743], 'K.': [1021, 1196, 1243, 1278, 1404, 1427, 1744, 1767, 1867, 2135, 2160], 'Wattiez': [1022, 1405, 1745], 'R.': [1023, 1177, 1215, 1232, 1406, 1468, 1746], 'Hermans': [1024, 1407, 1747], 'Duconseille': [1026, 1409, 1749], 'E.': [1027, 1219, 1410, 1750, 1913, 1936, 2326], 'Falmagne': [1028, 1411, 1751], 'P.': [1029, 1412, 1752, 4083], 'Bernard': [1030, 1413, 1753, 1978, 2054], '274:': [1036, 1419, 1482, 1759, 2262], '30451-30458Google': [1037, 1420, 1760], 'mouse': [1040, 1090, 1344, 1634, 1692, 1711, 1962, 2075, 2347, 2768, 2839], 'recently': [1047, 1709, 2372], 'PRDX5.': [1049], 'avoid': [1051], 'misunderstanding,': [1052], 'better': [1055], 'understand': [1056], 'literature': [1058], 'cited': [1059], 'report,': [1062], 'include': [1064], 'standard': [1067, 1095, 1100, 1117, 1527, 1544], 'positions': [1073, 3580], 'Cys': [1076, 1669, 1684], 'residues,': [1077], 'synonyms,': [1079], 'locations': [1084], 'Table': [1086, 3888], 'I.Table': [1087], 'ISubfamily': [1088], 'nomenclatureMouse': [1096], 'geneaGene': [1097], 'symbols': [1098, 1115, 1525, 1542], 'follow': [1099, 1116, 1526, 1543], 'defined': [1102, 1119, 1529, 1546], 'International': [1105, 1532], 'Committee': [1106, 1127, 1533, 1554], 'Standardized': [1108, 1535], 'Genetic': [1109, 1536], 'Nomenclature': [1110, 1126, 1537, 1553], 'Mice': [1112, 1539], '(www.informatics.jax.org/support/nomen/).Human': [1113], 'genebGene': [1114], 'Human': [1122, 1155, 1549, 1578], 'Genome': [1123, 1135, 1156, 1303, 1331, 1550, 1559, 1579, 1593, 1621, 3870], 'Organization': [1124, 1551], '(HUGO)': [1125, 1552], '(www.gene.ucl.ac.uk/nomenclature/).Conserved': [1128], 'CysCellular': [1129], 'locationMouse': [1130], 'synonymsMouse': [1131], 'ChrcRetrieved': [1132], 'from': [1133, 1144, 1299, 1329, 1557, 1567, 1589, 1619, 1681, 2626, 2811, 3065, 3076, 3151, 3185, 3261, 3446, 3503, 3648, 3665, 3964], 'Database': [1136, 1332, 1560, 1622], '(www.informatics.jax.org),': [1137, 1561], 'Chr—cM.Human': [1141], 'synonymsHuman': [1142], 'ChrdRetrieved': [1143], 'NCBI': [1145, 1568], 'LocusLink': [1146, 1569], '(www.ncbi.nlm.nih.gov/LocusLink),': [1147, 1570], 'checked': [1149, 1572, 3861], 'fine': [1151, 1574], 'position': [1152, 1293, 1323, 1335, 1342, 1575, 1583, 1613, 1625, 1632], 'Ensembl': [1154, 1301, 1577, 1591, 3868], 'Browser': [1157, 1580], '(www.ensembl.org/Homo_sapiens/).Refs.Prdx1PRDX147,': [1158], '170CytosolMSP23/OSF34-47PAG/NKEFA1p34.143Prosperi': [1159], 'M.T.': [1160], 'Apiou': [1161], 'F.': [1162], 'Dutrillaux': [1163], 'Goubin': [1165], 'G.': [1166, 1247, 1249, 2240, 2324], 'Genomics.': [1167, 1506, 1519, 2356, 2881], '1994;': [1168, 1181, 1223, 1236, 1259], '19:': [1169], '236-241Google': [1170], '44Shau': [1172], 'H.': [1173, 1190, 1228, 1462, 1477, 1503, 1871, 2353, 4089], 'Butterfield': [1174, 1229], 'L.H.': [1175, 1230], 'Chiu': [1176, 1231], 'Immunogenetics.': [1180, 1235], '40:': [1182, 1237], '129-134Google': [1183, 1238], '45Ishii': [1185], 'T.': [1186, 1264, 1365, 1873, 1875, 2173, 2279], 'Yamada': [1187], 'M.': [1188, 1192, 1213, 1270, 1284, 1369, 4085], 'Sato': [1189], 'Matsue': [1191], 'Taketani': [1193], 'S.': [1194, 1200, 1209, 1211, 1257, 1268, 1464, 1466, 1473, 1488, 1492, 1863, 1881, 2187, 2293, 2322, 2328, 2336, 2340], 'Nakayama': [1195], 'Sugita': [1197], 'Y.': [1198, 1266, 1865, 2171, 2253, 2277, 2302], 'Bannai': [1199], '1993;': [1204], '268:': [1205], '18633-18636Google': [1206], '46Kawai': [1208], 'Takeshita': [1210], 'Okazaki': [1212], 'Kikuno': [1214], 'Kudo': [1216], 'Amann': [1218], 'J': [1220, 1388], 'Biochem.': [1221, 1285, 1389, 1453, 1793, 2329, 2741, 4094], '(Tokyo).': [1222, 1390], '115:': [1224], '641-643Google': [1225], 'ScholarPrdx2PRDX247,': [1226], '170CytosolTSA8-36TSA/NKEFB13q1244Shau': [1227], '47Chae': [1240], 'Robison': [1242], 'Poole': [1244, 1950], 'L.B.': [1245, 1951], 'Church': [1246], 'Storz': [1248], 'Proc.': [1252, 1876, 2182, 2288], 'Natl.': [1253, 1877, 2183, 2289], 'Acad.': [1254, 1878, 2184, 2290], 'Sci.': [1255, 1879, 2185, 2291], 'U.': [1256, 1880, 2186, 2292], '91:': [1260], '7017-7021Google': [1261], 'ScholarPrdx3PRDX347,': [1262], '170MitochondriaMER5/AOP119-50MER5/AOP110q26.1248Yamamoto': [1263], 'Matsui': [1265], 'Natori': [1267], 'Obinata': [1269, 1283], 'Gene': [1271, 1524, 1541], '(Amst.).': [1272], '1989;': [1273], '80:': [1274], '337-343Google': [1275], '49Tsuji': [1277], 'Copeland': [1279], 'N.G.': [1280], 'Jenkins': [1281], 'N.A.': [1282], '1995;': [1287], '307:': [1288], '377-381Google': [1289], 'ScholarPrdx4PRDX447,': [1290], '170Cytosol,': [1291], 'extracellularPRDXIVX-65.4ePhysical': [1292], 'retrieved': [1298, 1328, 1588, 1618], 'Server': [1304, 1594, 3871], '(www.ensembl.org/Mus_musculus).': [1305, 1595], 'two': [1307, 1597, 1849, 3509], 'flanking': [1308, 1598], 'markers,': [1309, 1599], 'DXMit133': [1310, 1600], 'DXMit178,': [1312, 1602], 'either': [1314, 1604, 3418], 'side': [1315, 1605], 'shown': [1317, 1607, 3886], 'both': [1319, 1609, 3246], 'genetic': [1322, 1341, 1612, 1631], 'cM': [1325, 1615], '65.4': [1326, 1616], '(www.informatics.jax.org).': [1333, 1623], 'This': [1334, 1624, 2908, 2943], 'therefore': [1337, 1627, 1704], 'Prdx4.AOE372Xp22.1140Jin': [1345], '1997;': [1356, 1494, 1507, 2331, 2342, 2357], '272:': [1357], '30952-30961Google': [1358], '50Matsumoto': [1360], 'Okado': [1362], 'Fujii': [1364, 1366, 1384], 'Egashira': [1368], 'Niikawa': [1370], 'N.': [1371, 1373, 1387, 1869, 1919, 2236], 'Taniguchi': [1372, 1386], 'FEBS': [1374], 'Lett.': [1375], '443:': [1377], '246-250Google': [1378], '51Okado-Matsumoto': [1380], 'Matsumoto': [1382], '2000;': [1391, 1437, 1457, 1777, 1797, 1927, 1944, 2145, 2227, 2244], '127:': [1392], '493-501Google': [1393], 'ScholarPrdx5PRDX547,72,151Mitochondria': [1394], 'PeroxisomePMP20,': [1395], 'PRDXV19-0.5AOEB166,': [1396], 'PRDXV11q12.36Knoops': [1397], '7Seo': [1422, 1762, 2130], '275:': [1438, 1778, 2146, 2228, 2245], '20346-20354Google': [1439, 1779, 2147], '8Lee': [1441, 1781], 'S.J.': [1444, 1784], 'K.K.': [1448, 1788], 'Yu': [1451, 1791], 'Biophys.': [1454, 1794, 2742], 'Commun.': [1456, 1796, 2744], '270:': [1458, 1798, 4096], '356-362Google': [1459, 1799], '52Yamashita': [1461], 'Avraham': [1463, 1476], 'Jiang': [1465], 'London': [1467], 'Van': [1469], 'Veldhoven': [1470], 'P.P.': [1471], 'Subramani': [1472], 'Rogers': [1474], 'R.A.': [1475], '29897-29904Google': [1483], 'ScholarPrdx6PRDX647CytosolAOP21-83.6AOP2,': [1484], 'ORF6,': [1485], 'PLA2,': [1486], 'NSGPX1q23.322Frank': [1487], 'Munz': [1489, 2337], 'Werner': [1491, 2327, 2339], 'Oncogene.': [1493, 2341], '14:': [1495, 2343], '915-921Google': [1496, 2344], '23Iakoubova': [1498], 'O.A.': [1499, 2349], 'Pacella': [1500, 2350], 'L.A.': [1501, 2351], 'Her': [1502, 2352], 'Beier': [1504, 1515, 2354, 2877], 'D.R.': [1505, 1516, 2355, 2878], '42:': [1508, 2358], '474-478Google': [1509, 2359], '27Phelan': [1511], 'S.A.': [1512, 2874], 'Johnson': [1513, 2875], 'K.A.': [1514, 2876], 'Paigen': [1517, 2879, 4090], '54:': [1521, 2883], '132-139Google': [1522, 2884], 'Scholara': [1523], '(www.informatics.jax.org/support/nomen/).b': [1540], '(www.gene.ucl.ac.uk/nomenclature/).c': [1555], 'Retrieved': [1556, 1566], 'Chr—cM.d': [1565], '(www.ensembl.org/Homo_sapiens/).e': [1581], 'Physical': [1582], 'Prdx4.': [1635], 'Open': [1636, 4059], 'table': [1637, 4060], 'tab': [1641, 4064], 'All': [1642, 3124, 3979], 'contain': [1645, 1665, 1696, 1715], 'conserved': [1647, 1668], 'cysteine': [1648, 1700, 4112], 'residue': [1649], 'NH2': [1652], 'termini': [1653], 'molecules,': [1656], 'corresponding': [1657, 1726, 1806, 2960, 3577], 'Cys47': [1659, 1719, 1728, 1808, 1991, 2043], 'yeast': [1661, 1690, 1730, 1810], 'PRDX.': [1662, 1707, 2628], 'Whereas': [1663, 2524], 'PRDX1–4': [1664], 'an': [1666, 2009, 2036, 2066, 2845], 'additional': [1667], 'COOH-terminal': [1672, 4117], 'region,': [1673], 'separated': [1676, 3786], '120–123': [1678], 'amino': [1679], 'acids': [1680], 'NH2-terminal-conserved': [1683, 1699], 'corresponds': [1686], 'Cys170': [1688], 'only': [1697], '(Cys47)': [1701], 'termed': [1705], 'identified': [1710], 'PRDX5s': [1714], 'three': [1716], 'cysteines:': [1717], '(in': [1720, 1724, 3423], 'humans)': [1721], 'Cys36': [1723], 'PRDX),': [1731], 'Cys72,': [1733], 'Cys151': [1736, 2045], 'appears': [1802], 'Cys47,': [1805], 'common': [1813], 'subgroups,': [1818], 'active': [1821, 2540], 'site': [1822, 3119], 'oxidized': [1823, 2078], '2-Cys': [1840, 1995, 2627], 'exist': [1844], 'homodimers,': [1846], 'monomers': [1850], 'arranged': [1851], 'head-to-tail': [1854], 'manner,': [1855], 'supported': [1857], 'crystal': [1859], 'structure': [1860], 'analysis': [1861], '(9Hirotsu': [1862], 'Abe': [1864], 'Okada': [1866], 'Nagahara': [1868], 'Hori': [1870], 'Nishino': [1872], 'Hakoshima': [1874], '96:': [1884], '12333-12338Google': [1885], '10Choi': [1887], 'Yang': [1891], 'C.H.': [1892], 'Ryu': [1895], 'S.E.': [1896], 'Nat.': [1897], 'Struct.': [1898], '5:': [1901], '400-406Google': [1902], 'activity': [1906], 'likely': [1907], 'depends': [1908], 'quaternary': [1910], 'structures': [1911], '(11Schroder': [1912], 'Littlechild': [1914], 'J.A.': [1915, 2238], 'Lebedev': [1916], 'A.A.': [1917, 1921], 'Errington': [1918], 'Vagin': [1920], 'Isupov': [1922], 'M.N.': [1923], 'Structure': [1924], 'Fold': [1925], 'Des.': [1926], '8:': [1928], '605-615Google': [1929], '12Alphey': [1931], 'Bond': [1933], 'C.S.': [1934], 'Tetaud': [1935], 'Fairlamb': [1937], 'A.H.': [1938], 'Hunter': [1939], 'W.N.': [1940], 'Mol.': [1942, 1983, 2059], '300:': [1945], '903-916Google': [1946], '13Wood': [1948], 'Z.A.': [1949], 'Hantgan': [1952], 'R.R.': [1953], 'Karplus': [1954], 'P.A.': [1955], 'Biochemistry.': [1956], '41:': [1958], '5493-5504Google': [1959], 'do': [1966], 'form': [1968, 2008], 'dimers': [1969], '(14Declercq': [1970, 2046], 'J.P.': [1971, 2047], 'Evrard': [1972, 2048], 'Stricht': [1976, 2052], 'D.V.': [1977, 2053], 'Knoops': [1980, 2056], '2001;': [1985, 2061, 2166], '311:': [1986, 2062], '751-759Google': [1987, 2063], 'When': [1989, 2031, 3380, 3406], '(Cys-SOH)': [1992], 'oxidized,': [1998, 2035], 'reacts': [2000], 'Cys170-SH': [2002], 'subunit': [2006], 'intermolecular': [2010], 'disulfide,': [2011], 'then': [2014, 2728], 'reduced': [2015, 2717], 'intramolecular': [2037, 2067], 'disulfide': [2038, 2068], 'bond': [2039], 'formed': [2041], 'Probably,': [2065], 'forms': [2070], 'when': [2071, 3266, 3291], '(including': [2074], 'PRDX6)': [2076], 'In': [2092], 'vitro,': [2093], 'PRDX1-5': [2094], 'use': [2095], 'system': [2098], 'non-physiological': [2100], 'dithiothreitol': [2101], 'electron': [2103, 2115], 'donors,': [2104], 'uses': [2108], 'cyclophilin': [2109], 'A,': [2110], 'dithiothreitol,': [2111], 'donors': [2116], '15Lee': [2149], 'S.P.': [2150], 'Hwang': [2151], 'Y.S.': [2152], 'Y.J.': [2154], 'Kwon': [2155], 'K.S.': [2156], '276:': [2167], '29826-29832Google': [2168], '16Manevich': [2170], 'Sweitzer': [2172, 2278], 'Pak': [2174, 2280], 'J.H.': [2175, 2281, 2300], 'Feinstein': [2176, 2218, 2256, 2282, 2305], 'S.I.': [2177, 2219, 2257, 2283, 2306], 'Muzykantov': [2178, 2284], 'V.': [2179, 2285], 'Fisher': [2180, 2222, 2286, 2307], 'A.B.': [2181, 2223, 2249, 2287, 2308], '99:': [2190, 2296], '11599-11604Google': [2191, 2297], 'can': [2195, 2266, 2715, 2758], 'remove': [2196], 'phospholipid': [2199, 2271], '17Chen': [2214], 'J.W.': [2215, 2255], 'Dodia': [2216, 2250], 'Jain': [2220], 'M.K.': [2221], '28421-28427Google': [2229], '18Pedrajas': [2231], 'J.R.': [2232], 'Miranda-Vizuete': [2233], 'Javanmardy': [2235], 'Gustafsson': [2237], 'Spyrou': [2239], '16296-16301Google': [2246], '19Fisher': [2248], 'Manevich': [2252, 2301], 'Chen': [2254], '21326-21334Google': [2263], 'Scholar)': [2264, 2345, 2360], 'accumulation': [2269], 'hydroperoxides': [2272], 'plasma': [2274], 'membrane': [2275, 3561], '(16Manevich': [2276], '20Pak': [2299], 'H.S.': [2304], '277:': [2313], '49927-49934Google': [2314], 'Both': [2316], '(21Munz': [2319], 'Frank': [2321], 'Hubner': [2323], 'Olsen': [2325], '326:': [2332], '579-585Google': [2333], '22Frank': [2335], '(23Iakoubova': [2348], 'cDNAs': [2361], 'been': [2363, 2463], 'cloned.': [2364], 'gained': [2367], 'attention': [2371], 'because': [2373], 'role': [2376, 2625], 'second': [2379, 2426], 'messenger': [2380, 2427], 'variety': [2383], 'cytokines': [2385], 'factors,': [2388], 'PDGF': [2391], '(platelet-derived': [2392], 'factor),': [2394, 2398, 2413], 'EGF': [2395], '(endothelial': [2396], 'TNF-α': [2399], '(tumor': [2400], 'necrosis': [2401], 'α),': [2403], 'TGFβ': [2404], '(transforming': [2405], 'β),': [2408], 'bFGF': [2409], '(basic': [2410], 'fibroblast': [2411], 'IFNγ': [2414], '(interferon': [2415], 'γ),': [2416], 'IL-1': [2418], '(interleukin': [2419], '1).': [2420], 'acts': [2423], 'molecules': [2430, 2461], 'angiotensin': [2433], 'II,': [2434], 'thrombin,': [2435], 'lysophosphatidic': [2436], 'acid,': [2437], 'phorbol': [2438], 'ester,': [2439], 'density': [2443], 'lipoprotein': [2444], '(24Rhee': [2445, 2502], 'Exp': [2447, 2504], 'Mol': [2448, 2505], 'Med.': [2449, 2506], '31:': [2451, 2508], '53-59Google': [2452, 2509], 'generation': [2455, 4069], 'stimulated': [2458], 'related': [2464], 'activation': [2467], 'transcription': [2469], 'factors': [2470], '(such': [2471], 'NF-κB': [2473], 'AP-1,': [2475], 'mitogen-activated': [2476], 'kinase,': [2478], 'D,': [2482], 'kinase': [2485], 'C),': [2486], 'increased': [2487], 'cytosolic': [2490], 'calcium,': [2491], 'triggering': [2493], 'apoptosis,': [2495], 'inhibition': [2498], 'protein-tyrosine': [2500], 'phosphatases': [2501], 'Thus': [2511], 'might': [2514, 2606, 2621], 'influence': [2515], 'transduction': [2518], 'pathways': [2519], 'regulating': [2521], 'able': [2530], '(OH•)': [2536], 'highest': [2544], 'reason': [2565], 'believe': [2567], 'generating': [2575], 'OH•': [2576, 2778], 'Fenton': [2579, 2781], 'reaction': [2580, 3949], '(25Stadtman': [2581], 'E.R.': [2582], 'Berlett': [2583], 'B.S.': [2584], 'Drug': [2585], 'Metab.': [2586], 'Rev.': [2587], '30:': [2589], '225-243Google': [2590], 'Scholar):': [2591], '+': [2593, 2596, 2598], 'Fe2+→': [2594], 'Fe(III)': [2595], 'OH–': [2597], 'OH•.': [2599], 'So': [2600], 'eliminating': [2604], 'H2O2,': [2605], 'be': [2607, 2716, 2759, 3844], 'involved': [2608], 'protecting': [2610], 'stress-mediated': [2612], 'injury,': [2614], 'structure,': [2620], 'play': [2622], 'distinct': [2624], 'reducing': [2638], 'acting': [2642], 'vivo,': [2647], 'challenged': [2655], 'them': [2656], 'controls': [2659, 3391], 'paraquatinduced': [2662], 'stress.': [2664], 'Paraquat': [2665], '(1,1′-dimethyl-4,4′-bipyridylium': [2666], 'dichloride;': [2667], 'PQ2+)': [2668], 'within': [2676, 3126, 3276, 3593], 'cells,': [2677, 2756], 'extensive': [2681], 'responsible': [2686], 'PQ2+': [2692], 'bipyridyl': [2712], 'herbicide': [2713], 'NADPH-cytochrome': [2719], 'P-450': [2720], 'reductase': [2721], 'into': [2724, 2761, 2936, 2994, 3040, 3115, 3144, 3183, 3191], 'radicals,': [2726], 'react': [2729], 'O2': [2731], 'O2.−': [2734, 2751], '(26Bus': [2735], 'J.S.': [2736], 'Aust': [2737], 'S.D.': [2738], 'Gibson': [2739], 'J.E.': [2740], '1974;': [2745], '58:': [2746], '749-755Google': [2747], 'While': [2749], 'itself': [2752], 'harmful': [2754], 'dismutated': [2760], 'SODs.': [2764], 'We': [2765], 'hypothesized': [2766], 'would': [2770, 4125], 'eliminate': [2771], 'number': [2776], 'produced': [2779], 'reactions': [2782, 3943], 'subsequent': [2784], 'injury.': [2786], 'mutants': [2788, 2814, 3346, 3354], 'mortality': [2798], 'rate': [2799], 'than': [2800], 'did': [2801], 'controls,': [2802], 'independent': [2803], 'major': [2806], 'enzymes.': [2808, 2854], 'susceptible': [2823], 'oxidant-induced': [2825], 'that,': [2832], 'stress,': [2838], 'non-redundantly': [2848], 'Generation': [2855, 4065], 'Mutant': [2858], 'Mice—A': [2859], 'genomic': [2860, 2926, 3586], 'clone': [2861, 2887, 2927, 3005, 3018, 3050], 'containing': [2862, 2896, 3052, 3060, 3204], '129/SvJ': [2864, 3348, 3420], '(129)': [2865, 3349], 'isolated': [2869, 2917, 2946], 'previously': [2871], 'described': [2872, 4076], '(27Phelan': [2873], 'digested': [2889, 2929, 2949, 2980, 3026, 3094, 3106, 3485, 3546], 'BglI,': [2891], '5094-bp': [2894], 'fragment': [2895, 2944, 2959, 3253], 'upstream': [2898], 'regulatory': [2899], 'regions': [2900], '(position': [2901], '1606–6700)': [2902], 'isolated.': [2907], 'represented': [2909], '5′-arm': [2911, 3054, 3595], 'Prdx6.': [2913, 2970], '3′-arm': [2915, 2968, 3012], 'using': [2918, 3082, 3619, 3630, 3656, 3706, 3803, 3817, 3918, 4106], 'multiple': [2920], 'step': [2921, 3305, 3741], 'cloning': [2922, 2974, 3086], 'method.': [2923], 'First,': [2924], 'NarI': [2931], 'SacII,': [2933], 'cut': [2935], 'intron': [2937, 3248], 'exon': [2940], '5,': [2941], 'respectively.': [2942], 'partially': [2948, 3105], 'NsiI': [2951], 'obtain': [2953], 'correct': [2955, 3004, 3117], 'segment.': [2956], '4594-bp': [2958], 'nucleotides': [2962], '10,872–15,470': [2963], 'isolated,': [2965], 'representing': [2966], 'Litmus': [2972], '29': [2973], 'vector': [2975, 3087, 3269, 3294], '(New': [2976], 'England': [2977], 'Biolabs)': [2978], 'NsiI,': [2982], 'dephosphorylated,': [2983], 'ligated': [2985, 3030], '3′-arm.': [2988], 'ligation': [2990, 3036], 'products': [2991, 3037, 3784], 'transformed': [2993, 3039], 'CE4': [2995, 3041], 'colonies': [2998, 3044], 'screened': [2999, 3045, 3163, 3223], 'restriction': [3001, 3047], 'digestion.': [3002, 3048], '(named': [3006], 'p182)': [3007], 'obtained,': [3009], 'verified': [3014, 3131], 'sequencing.': [3016, 3133], '5′-arm,': [3020], 'p182': [3022], 'plasmid': [3023, 3059, 3092, 3103], 'EcoRV': [3028], 'T4-blunt-ended': [3033], '5′-arm.': [3034], '(p184)': [3051], 'obtained.': [3056], 'pSABgal': [3058, 3091], 'SA': [3062], 'splice': [3063], 'acceptor': [3064], 'adenovirus,': [3066], 'Bgal': [3067], 'gene,': [3068, 3072, 3280], 'PGK': [3069], 'promoter,': [3070], 'neomycin': [3071], 'PA': [3074], 'bovine': [3077, 4128], 'hormone': [3079], 'pXhopKS': [3084], '(–)': [3085], '(Stratagene).': [3088], '7.9-kb': [3090], 'XhoI,': [3096, 3108], 'releasing': [3097], 'Bgal-Neo': [3099, 3111], 'cassette.': [3100], 'p184': [3102], 'cassette': [3112], 'cloned': [3114], 'XhoI': [3118], 'targeted': [3122, 3135, 3216, 3376, 3398, 3598], 'construct.': [3123, 3600], 'junctions': [3125], 'targeting': [3128, 3268, 3293], 'construct': [3129, 3137, 3166, 3207], 'mutation': [3136, 3367], 'linearized': [3139], 'SwaI': [3141], 'electroporated': [3143], 'ES': [3146, 3159], 'Cell': [3147], 'Line': [3148], 'R1': [3149], '(Derived': [3150], '129': [3152, 3358, 3412], 'mice).': [3153], 'Using': [3154], '5′-and': [3155], '3′-probes,': [3156], 'over': [3157], '100': [3158, 3476, 3479], 'clones': [3161, 3177], 'blotting': [3169], '(EcoNI': [3170], 'digests).': [3171], 'total': [3173, 3663, 3697, 3910], '11': [3175], 'positive': [3176], 'identified.': [3179], 'These': [3180], 'microinjected': [3182], 'blastocysts': [3184], 'C57BL/6J': [3186], '(B6)': [3187], 'implanted': [3190], 'pseudopregnant': [3192], 'females.': [3193], 'Chimeric': [3194], 'crossed': [3197, 3356], 'B6': [3199], 'once,': [3200], 'offspring': [3203], 'intercrossed': [3209, 3369], 'generate': [3211, 3344, 3371], 'homozygous': [3213, 3373], 'non-targeted': [3218], 'alleles,': [3220], 'PCR.': [3225], 'primers': [3227, 3603, 3832, 3837, 3847, 3859, 3900], 'screening': [3229], 'were:': [3230], '0368': [3231, 3242], 'forward,': [3232, 3235, 3728], '5′-CAGGATGGAGCCTCTATGCC-3′;': [3233], '0369': [3234, 3274], '5′-TGGCTTCTGAGACGGAAAGAA-3′;': [3236], '0366': [3238, 3244], 'reverse,': [3239, 3730], '5′-CTTTGAACAGAACCAGGCAGG-3′.': [3240], 'Primers': [3241, 3814], 'amplify': [3251, 3721], 'intron,': [3256], 'giving': [3257], '199-bp': [3259], 'product': [3260, 3290, 3576], 'endogenous': [3263], 'present.': [3272, 3296], 'Primer': [3273, 3822], 'falls': [3275, 3589], 'inserted': [3278], 'Neo': [3279], 'together': [3282], 'primer': [3284, 3708, 3819, 3879], '0366,': [3285], 'they': [3286], 'give': [3287], '315-bp': [3289], 'PCR': [3297, 3570, 3575, 3644, 3734, 3800, 3915, 3942, 3955, 3980], 'follows:': [3301], 'one': [3302, 3738], '2-min': [3303], 'denaturation': [3304, 3740], 'at': [3306, 3317, 3323, 3330, 3340, 3492, 3742, 3756, 3762, 3769, 3779, 3930], '94': [3307, 3757], '°C': [3308, 3744, 3923, 3932, 3938], 'followed': [3309, 3745], '36': [3311, 3750], 'cycles': [3312, 3751, 3929], '30': [3315, 3321, 3328, 3754, 3760], 's': [3316, 3322, 3329, 3755, 3761, 3935], '92': [3318], '°C,': [3319, 3325, 3332, 3758, 3764, 3771], '55': [3324, 3493, 3763], '70': [3331], 'final': [3335, 3774, 3783], 'extension': [3336, 3775], '3': [3338], 'min': [3339, 3768, 3778], '72': [3341, 3770, 3780], '°C.': [3342, 3494, 3781], 'background,': [3350], 'chimeric': [3352], 'offsprings': [3362], 'heterozygous': [3363], 'mutation.': [3379], 'mixed': [3385, 3898], 'B6;129': [3386], 'background': [3387, 3413], 'used,': [3389, 3415], 'littermates': [3395, 3429], 'mutants,': [3399], 'same': [3402, 3436, 3966], 'age': [3403], 'sex.': [3405], 'pure': [3411], 'inbred': [3421], 'studies)': [3426], '(for': [3430], 'isolation': [3431], 'macrophages),': [3433], 'sex': [3437], 'age.': [3439], 'Preparation': [3440], 'Genomic': [3442], 'DNA—DNA': [3443], 'extracted': [3445, 3497, 3654, 3671], 'tail': [3448, 3461, 3469, 3543], 'tips': [3449], 'each': [3451, 3460, 3834, 3855], 'experimental': [3452], 'control': [3454], 'mouse.': [3455], 'Approximately': [3456], '1': [3457, 3488, 3523, 3767, 3940], 'cm': [3458], 'tip': [3462], 'placed': [3464], '500': [3466], 'μl': [3467], 'buffer': [3470], '(50': [3471], 'mm': [3472, 3477, 3480], 'Tris-Cl': [3473], 'pH': [3474], '8.0,': [3475], 'EDTA,': [3478], 'NaCl,': [3481], '1%': [3482], 'SDS)': [3483], 'overnight': [3486], 'mg/ml': [3489], 'proteinase': [3490], 'K': [3491], 'DNA': [3495, 3516, 3544], 'phenol/choloroform/isoamyl': [3499], 'alcohol': [3500], 'precipitated': [3502, 3515], 'upper': [3505], 'aqueous': [3506], 'phase': [3507], 'volumes': [3510], '100%': [3512], 'ethanol.': [3513], 'pellets': [3517], 'dried': [3519], 'resuspended': [3521], 'ml': [3524], 'Tris': [3526], 'buffer-EDTA': [3527], '(pH': [3528], '7.5–8.0).': [3529], 'Blots—Southern': [3531], 'blots': [3532, 3627], 'detect': [3536], 'gene.': [3539], '10': [3540, 3925], 'μg': [3541, 3695], 'EcoNI,': [3548], 'electrophoresed': [3549], '0.7%': [3552], 'agarose': [3553, 3789], 'gel,': [3554], 'transferred': [3556], 'Hybond': [3559], 'nylon': [3560], '(Amersham': [3562, 3623, 3636], 'Biosciences).': [3563, 3637], 'Prdx6-specific': [3565], 'probe': [3566, 3611], 'amplification': [3571], '530-bp': [3574], 'nucleotide': [3579], '663–1193': [3581], 'original': [3584], 'p165': [3585], 'sequence,': [3587], 'near': [3590], '5′-end': [3592], 'following': [3602, 3680, 3733, 3920], 'used:': [3605, 3737], 'forward': [3606, 3829], '5′-GTGACCACGCCCCTCAGCACTC-3′;': [3607], 'reverse': [3608, 3831], '5′-CCTCGGATCAGGCTTCCCTCC-3′.': [3609], 'labeled': [3613], '32P': [3615], 'random': [3617], 'priming': [3618], 'Redi-Prime': [3621], 'kit': [3622, 3676, 3702], 'Biosciences),': [3624], 'hybridized': [3629], 'Rapid-Hybe': [3632], 'solution': [3633], 'protocol': [3635], 'Reverse': [3638], 'Transcription': [3639], '(RT)-PCR': [3640], 'Real': [3642], 'Time': [3643], 'Analysis—': [3645], 'Total': [3646], 'RNA': [3647, 3664, 3698], 'brain': [3649], 'fat': [3651], 'RNeasy': [3657, 3674], 'Lipid': [3658], 'Tissue': [3659], 'Mini': [3660, 3675], 'kit,': [3661], '(Qiagen,': [3677, 3703], 'Valencia,': [3678], 'CA),': [3679], "manufacturer's": [3682], 'instructions.': [3683], 'RT-PCR': [3684, 3895], 'performed': [3686, 3802, 3945, 3983], 'follows.': [3688], 'cDNA': [3689, 3714, 3853, 3890], 'synthesized': [3691], 'reverse-transcribing': [3693], 'Omniscript': [3700], 'RT': [3701], 'Hilden,': [3704], 'Germany),': [3705], 'oligo(dT)15': [3707], '(Promega,': [3709], 'Madison,': [3710], 'WI).': [3711], 'template': [3719], 'transcripts': [3724], 'primers:': [3727], '5′-TTGATGATAAGGGCAGGGAC-3′;': [3729], '5′-CTACCATCACGCTCTCTCCC-3′.': [3731], 'condition': [3735], '5-min': [3739], '95': [3743, 3922, 3931], '19,': [3747], '28,': [3748], '7': [3777], '2.5%': [3788], '3:1': [3790], '(Amresco)': [3791], 'visualized': [3793], 'ethidium': [3795], 'bromide': [3796], 'staining.': [3797], 'Quantitative': [3798, 3953], 'real-time': [3799, 3954, 3994], 'ABI': [3805], 'Prism': [3806], '7000': [3807], 'Sequence': [3808, 3973], 'Detection': [3809], 'System': [3810], '(PE': [3811, 3825, 3905, 3976], 'Applied': [3812, 3826, 3906, 3977], 'Biosystems).': [3813, 3827, 3952, 3978], 'designed': [3816], 'design': [3820], 'software': [3821, 3975], 'Express': [3823], '2.0': [3824], 'pair': [3835, 3857], 'located': [3839], 'different': [3841], 'exons.': [3842], 'sure': [3845], 'amplified': [3848], 'desired': [3852], 'segment,': [3854], 'BLAST': [3864], 'program': [3865], '(www.ensembl.org/Musmusculus/)': [3872], 'Celera': [3874], 'data': [3875, 3969], 'base': [3876], '(www.celera.com).': [3877], 'sequences': [3880, 3987], 'II.': [3889], 'samples,': [3891], 'prepared': [3892], 'above,': [3896], 'SYBR': [3902], 'Master': [3903], 'Mix': [3904], 'Biosystems)': [3907], 'volume': [3911], '25': [3913], 'μl.': [3914], 'conducted': [3917], 'parameters:': [3921], 'min,': [3926], '40': [3928], '15': [3934], '60': [3937], 'min.': [3941], '96-well': [3947], 'optical': [3948], 'plates': [3950], '(Applied': [3951], 'normalized': [3957], 'copies': [3960], 'β-actin': [3962], 'sample.': [3967], 'Acquired': [3968], 'analyzed': [3971], 'Detector': [3974], 'assays': [3981], 'triplicate.Table': [3985], 'IIPrimers': [3986], 'PCRGene/SymbolGene': [3995], 'namePrimersPrdx1Peroxiredoxin': [3996], '1F,': [3997, 4018, 4034, 4038, 4042, 4045, 4051], '5′-ACACCCAAGAAACAAGGAGGATT-3′R,': [3998], '5′-CAACGGGAAGATCGTTTATTGTTA-3′Prdx2Peroxiredoxin': [3999], '2F,': [4000, 4022, 4048, 4054], '5′-AACGCGCAAATCGGAAAGT-3′R,': [4001], '5′-AGTCCTCAGCATGGTCGCTAA-3′Prdx3Peroxiredoxin': [4002], '3F,': [4003, 4026], '5′-GGCCACATGAACATCACACTGT-3′R,': [4004], '5′-CAAACTGGAACGCCTTTACCA-3′Prdx4Peroxiredoxin': [4005], '4F,': [4006, 4030], '5′-TCCTGTTGCGGACCGAAT-3′R,': [4007], '5′-GATCTTGGCTTTGCTTAGATGCA-3′Prdx5Peroxiredoxin': [4008], '5F,': [4009], '5′-GAAAGAAGCAGGTTGGGAGTGT-3′R,': [4010], '5′-CCCAGGGACTCCAAACAAAA-3′Prdx6Peroxiredoxin': [4011], '6F,': [4012], '5′-TTGATGATAAGGGCAGGGAC-3′R,': [4013], '5′-CTACCATCACGCTCTCTCCC-3′CatCatalaseF,': [4014], '5′-GCGTCCAGTGCGCTGTAGA-3′R,': [4015], '5′-TCAGGGTGGACGTCAGTGAA-3′Gpx1Glutathione': [4016], 'peroxidase': [4017, 4021, 4025, 4029], '5′-GGGACTACACCGAGATGAACGA-3′R,': [4019], '5′-ACCATTCACTTCGCACTTCTCA-3′Gpx2Glutathione': [4020], '5′-GAGGAACAACTACCCGGGACTA-3′R,': [4023], '5′-ACCCCCAGGTCGGACATACT-3′Gpx3Glutathione': [4024], '5′-GCCAGCTACTGAGGTCTGACAGA-3′R,': [4027], '5′-CCACCTGGTCGAACATACTTGAG-3′Gpx4Glutathione': [4028], '5′-TCTGGCAGGCACCATGTGT-3′R,': [4031], '5′-CGGGCATGCAGATCGACTA-3′Sod1Superoxide': [4032], 'dismutase': [4033, 4037, 4041], '5′-TGGGTTCCACGTCCATCAGTA-3′R,': [4035], '5′-ACCGTCCTTTCCAGCAGTCA-3′Sod2Superoxide': [4036], '5′-ATTAACGCGCAGATCATGCA-3′R,': [4039], '5′-TGTCCCCCACCATTGAACTT-3′Sod3Superoxide': [4040], '5′-CCAGCTTCGACCTAGCAGACA-3′R,': [4043], '5′-CAGCGTGGCTGATGGTTGTA-3′Txn1Thioredoxin': [4044], '5′-TTTCCATCTGGTTCTGCTGAGA-3′R,': [4046], '5′-TGGAAGAAGGGCTTGATCATTT-3′Txn2Thioredoxin': [4047], '5′-GGACCGCGGCTAGAGAAGAT-3′R,': [4049], '5′-GCTGGTCCTCGTCCTTGATC-3′Glrx1Glutaredoxin': [4050], '5′-CAACACCAGTGCGATTCAAGA-3′R,': [4052], '5′-GCAGAGCTCCAATCTGCTTCA-3′Glrx2Glutaredoxin': [4053], '5′-TGGAATATGGCAACCAGTTTCA-3′R,': [4055], '5′-GGCGACTATCCACATCATTCAA-3′Bactβ-ActinF,': [4056], '5′-ATGGAATCCTGTGGCATCCA-3′R,': [4057], '5′-CGCTCAGGAGGAGCAATGAT-3′': [4058], 'PRDX6-specific': [4067], 'Antibodies—The': [4068], 'specific': [4071], 'antibodies': [4072], 'against': [4073], 'elsewhere': [4077], '(28Stuhlmeier': [4078], 'K.M.': [4079], 'Kao': [4080], 'J.J.': [4081], 'Wallbrandt': [4082], 'Lindberg': [4084], 'Hammarstrom': [4086], 'Broell': [4088], 'Eur.': [4092], '2003;': [4095], '334-341Google': [4097], 'polyclonal': [4100], 'antibody': [4101], '(rabbit': [4102], 'IgG)': [4103], 'synthetic': [4108], 'peptide,': [4109], 'FPKGVFTKELPSGKKYLRYC': [4110], '(a': [4111], 'added': [4114], 'end': [4118], 'peptide': [4121], 'so': [4122], 'couple': [4126], 'serum': [4129], 'albumin': [4130], 'affinity': [4132], 'ge': [4133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051343147', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-11T18:34:41.676539', 'created_date': '2016-06-24'}