Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2051268743', 'doi': 'https://doi.org/10.1016/j.nlm.2011.08.003', 'title': 'The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease', 'display_name': 'The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease', 'publication_year': 2011, 'publication_date': '2011-09-07', 'ids': {'openalex': 'https://openalex.org/W2051268743', 'doi': 'https://doi.org/10.1016/j.nlm.2011.08.003', 'mag': '2051268743', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21914486', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4390395'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.nlm.2011.08.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S78120914', 'display_name': 'Neurobiology of Learning and Memory', 'issn_l': '1074-7427', 'issn': ['1074-7427', '1095-9564'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4390395?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070851422', 'display_name': 'Sérgio T. Ferreira', 'orcid': 'https://orcid.org/0000-0001-7160-9866'}, 'institutions': [{'id': 'https://openalex.org/I122140584', 'display_name': 'Universidade Federal do Rio de Janeiro', 'ror': 'https://ror.org/03490as77', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I122140584']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Sergio T. Ferreira', 'raw_affiliation_strings': ['Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-590, Brazil.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-590, Brazil.', 'institution_ids': ['https://openalex.org/I122140584']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054687151', 'display_name': 'William L. Klein', 'orcid': 'https://orcid.org/0000-0002-3047-9978'}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William L. Klein', 'raw_affiliation_strings': ['Department of Neurobiology, Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University, Evanston, IL 60208, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University, Evanston, IL 60208, United States', 'institution_ids': ['https://openalex.org/I111979921']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3730, 'currency': 'USD', 'value_usd': 3730, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.389, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 411, 'citation_normalized_percentile': {'value': 0.704339, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '96', 'issue': '4', 'first_page': '529', 'last_page': '543'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase Inhibitors in Neurodegenerative Diseases', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.556778}, {'id': 'https://openalex.org/keywords/oligomer', 'display_name': 'Oligomer', 'score': 0.53054076}, {'id': "https://openalex.org/keywords/alzheimer's-disease", 'display_name': "Alzheimer's Disease", 'score': 0.527323}, {'id': 'https://openalex.org/keywords/aß-oligomers', 'display_name': 'Aß Oligomers', 'score': 0.511387}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.46706423}], 'concepts': [{'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.7638483}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.68208236}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.6451987}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.57480365}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.556778}, {'id': 'https://openalex.org/C2780642029', 'wikidata': 'https://www.wikidata.org/wiki/Q726004', 'display_name': 'Oligomer', 'level': 2, 'score': 0.53054076}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.52208155}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.46706423}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.4598497}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37522745}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3289476}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.32614297}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21531498}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.1679081}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.13512638}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.10581496}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058225', 'descriptor_name': 'Plaque, Amyloid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.nlm.2011.08.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S78120914', 'display_name': 'Neurobiology of Learning and Memory', 'issn_l': '1074-7427', 'issn': ['1074-7427', '1095-9564'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4390395', 'pdf_url': 'https://europepmc.org/articles/pmc4390395?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390395', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21914486', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4390395', 'pdf_url': 'https://europepmc.org/articles/pmc4390395?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 282, 'referenced_works': ['https://openalex.org/W120784412', 'https://openalex.org/W1500301897', 'https://openalex.org/W150222691', 'https://openalex.org/W1511127813', 'https://openalex.org/W1517772582', 'https://openalex.org/W1522472244', 'https://openalex.org/W1527910050', 'https://openalex.org/W1543788907', 'https://openalex.org/W1546369396', 'https://openalex.org/W1566564316', 'https://openalex.org/W1570302318', 'https://openalex.org/W1575733811', 'https://openalex.org/W157753509', 'https://openalex.org/W1582815220', 'https://openalex.org/W1584774790', 'https://openalex.org/W1584825376', 'https://openalex.org/W1584834830', 'https://openalex.org/W1605971438', 'https://openalex.org/W1616122655', 'https://openalex.org/W1637989849', 'https://openalex.org/W1677883125', 'https://openalex.org/W1695648810', 'https://openalex.org/W1705725530', 'https://openalex.org/W1710226705', 'https://openalex.org/W1718410121', 'https://openalex.org/W17230872', 'https://openalex.org/W173047358', 'https://openalex.org/W1802455527', 'https://openalex.org/W1819107323', 'https://openalex.org/W1857351893', 'https://openalex.org/W1864791610', 'https://openalex.org/W1913141297', 'https://openalex.org/W1951083945', 'https://openalex.org/W1963640549', 'https://openalex.org/W1963687105', 'https://openalex.org/W1964741226', 'https://openalex.org/W1967464880', 'https://openalex.org/W1967466236', 'https://openalex.org/W1967564647', 'https://openalex.org/W1968530575', 'https://openalex.org/W1968973248', 'https://openalex.org/W1969880746', 'https://openalex.org/W1970164987', 'https://openalex.org/W1970874743', 'https://openalex.org/W1971116512', 'https://openalex.org/W1971402768', 'https://openalex.org/W1972609075', 'https://openalex.org/W1974823287', 'https://openalex.org/W1975897546', 'https://openalex.org/W1976568654', 'https://openalex.org/W1976599886', 'https://openalex.org/W1976602187', 'https://openalex.org/W1978554758', 'https://openalex.org/W1979008330', 'https://openalex.org/W1980750700', 'https://openalex.org/W1981205792', 'https://openalex.org/W1981570625', 'https://openalex.org/W1981698244', 'https://openalex.org/W1982373527', 'https://openalex.org/W1982810155', 'https://openalex.org/W1984924722', 'https://openalex.org/W1985323612', 'https://openalex.org/W1985747467', 'https://openalex.org/W1986635066', 'https://openalex.org/W1986686062', 'https://openalex.org/W1987416014', 'https://openalex.org/W1987922097', 'https://openalex.org/W1989948422', 'https://openalex.org/W1990729227', 'https://openalex.org/W1990752558', 'https://openalex.org/W1991241547', 'https://openalex.org/W1991988242', 'https://openalex.org/W1992674527', 'https://openalex.org/W1993019632', 'https://openalex.org/W1993274829', 'https://openalex.org/W1993465897', 'https://openalex.org/W1993712369', 'https://openalex.org/W1993759415', 'https://openalex.org/W1994497989', 'https://openalex.org/W1995491925', 'https://openalex.org/W1995580860', 'https://openalex.org/W1995648866', 'https://openalex.org/W1996132904', 'https://openalex.org/W1998553787', 'https://openalex.org/W1998751065', 'https://openalex.org/W1999486225', 'https://openalex.org/W1999514420', 'https://openalex.org/W2001688761', 'https://openalex.org/W2001900724', 'https://openalex.org/W2002280328', 'https://openalex.org/W2002364516', 'https://openalex.org/W2002617729', 'https://openalex.org/W2003655335', 'https://openalex.org/W2004968757', 'https://openalex.org/W2007495000', 'https://openalex.org/W2007849320', 'https://openalex.org/W2008337884', 'https://openalex.org/W2008917014', 'https://openalex.org/W2009174342', 'https://openalex.org/W2009755157', 'https://openalex.org/W2010037905', 'https://openalex.org/W2011335492', 'https://openalex.org/W2011430246', 'https://openalex.org/W2013333500', 'https://openalex.org/W2014496428', 'https://openalex.org/W2014577085', 'https://openalex.org/W2014898742', 'https://openalex.org/W2015227366', 'https://openalex.org/W2015426193', 'https://openalex.org/W2016351953', 'https://openalex.org/W2016928060', 'https://openalex.org/W2017563414', 'https://openalex.org/W2019455863', 'https://openalex.org/W2020497815', 'https://openalex.org/W2021181758', 'https://openalex.org/W2021943859', 'https://openalex.org/W2024046612', 'https://openalex.org/W2025825556', 'https://openalex.org/W2027376281', 'https://openalex.org/W2028174194', 'https://openalex.org/W2029181104', 'https://openalex.org/W2029377385', 'https://openalex.org/W2030508474', 'https://openalex.org/W2031231661', 'https://openalex.org/W2031441539', 'https://openalex.org/W2032920422', 'https://openalex.org/W2033411034', 'https://openalex.org/W2033429522', 'https://openalex.org/W2034986487', 'https://openalex.org/W2035752811', 'https://openalex.org/W2036362108', 'https://openalex.org/W2037392168', 'https://openalex.org/W2040420412', 'https://openalex.org/W2040721710', 'https://openalex.org/W2040863516', 'https://openalex.org/W2041492570', 'https://openalex.org/W2042520955', 'https://openalex.org/W2043841065', 'https://openalex.org/W2044564411', 'https://openalex.org/W2045270516', 'https://openalex.org/W2045318822', 'https://openalex.org/W2045593157', 'https://openalex.org/W2046209489', 'https://openalex.org/W2046312724', 'https://openalex.org/W2046952010', 'https://openalex.org/W2053665966', 'https://openalex.org/W2053702542', 'https://openalex.org/W2054388625', 'https://openalex.org/W2054543840', 'https://openalex.org/W2055453151', 'https://openalex.org/W2055557113', 'https://openalex.org/W2056092494', 'https://openalex.org/W2056145172', 'https://openalex.org/W2057042201', 'https://openalex.org/W2057121506', 'https://openalex.org/W2057815562', 'https://openalex.org/W2058723245', 'https://openalex.org/W2059640473', 'https://openalex.org/W2061738346', 'https://openalex.org/W2062990728', 'https://openalex.org/W2063014525', 'https://openalex.org/W2064759294', 'https://openalex.org/W2064963539', 'https://openalex.org/W2065714966', 'https://openalex.org/W2066912813', 'https://openalex.org/W2068042361', 'https://openalex.org/W2069796133', 'https://openalex.org/W2070448139', 'https://openalex.org/W2070881916', 'https://openalex.org/W2072625029', 'https://openalex.org/W2073593094', 'https://openalex.org/W2073686561', 'https://openalex.org/W2073855709', 'https://openalex.org/W2075481535', 'https://openalex.org/W2075597274', 'https://openalex.org/W2075604126', 'https://openalex.org/W2075930760', 'https://openalex.org/W2076725316', 'https://openalex.org/W2076968916', 'https://openalex.org/W2078212921', 'https://openalex.org/W2078917784', 'https://openalex.org/W2080521700', 'https://openalex.org/W2080670841', 'https://openalex.org/W2081965230', 'https://openalex.org/W2081998222', 'https://openalex.org/W2082151254', 'https://openalex.org/W2082328452', 'https://openalex.org/W2082429191', 'https://openalex.org/W2082438248', 'https://openalex.org/W2082871116', 'https://openalex.org/W2083337622', 'https://openalex.org/W2083472480', 'https://openalex.org/W2083579642', 'https://openalex.org/W2084559483', 'https://openalex.org/W2084761782', 'https://openalex.org/W2084973310', 'https://openalex.org/W2087443596', 'https://openalex.org/W2087969945', 'https://openalex.org/W2088239473', 'https://openalex.org/W2088677347', 'https://openalex.org/W2088733194', 'https://openalex.org/W2088942395', 'https://openalex.org/W2090150925', 'https://openalex.org/W2090184064', 'https://openalex.org/W2090434536', 'https://openalex.org/W2090881453', 'https://openalex.org/W2091612053', 'https://openalex.org/W2091745370', 'https://openalex.org/W2093025761', 'https://openalex.org/W2093067743', 'https://openalex.org/W2093715230', 'https://openalex.org/W2094411486', 'https://openalex.org/W2094701828', 'https://openalex.org/W2095031277', 'https://openalex.org/W2095427358', 'https://openalex.org/W2095745901', 'https://openalex.org/W2096192426', 'https://openalex.org/W2097157695', 'https://openalex.org/W2097335530', 'https://openalex.org/W2098171772', 'https://openalex.org/W2099370040', 'https://openalex.org/W2099906733', 'https://openalex.org/W2101048381', 'https://openalex.org/W2101077392', 'https://openalex.org/W2103440561', 'https://openalex.org/W2104757313', 'https://openalex.org/W2109713145', 'https://openalex.org/W2109727228', 'https://openalex.org/W2109958697', 'https://openalex.org/W2110029042', 'https://openalex.org/W2111920180', 'https://openalex.org/W2113814333', 'https://openalex.org/W2115177689', 'https://openalex.org/W2116276594', 'https://openalex.org/W2116489922', 'https://openalex.org/W2118891894', 'https://openalex.org/W2121948289', 'https://openalex.org/W2121963977', 'https://openalex.org/W2122130235', 'https://openalex.org/W2122522567', 'https://openalex.org/W2126958454', 'https://openalex.org/W2128401893', 'https://openalex.org/W2128679037', 'https://openalex.org/W2129412868', 'https://openalex.org/W2129879090', 'https://openalex.org/W2129971794', 'https://openalex.org/W2131558033', 'https://openalex.org/W2133638306', 'https://openalex.org/W2135057867', 'https://openalex.org/W2136003325', 'https://openalex.org/W2136936410', 'https://openalex.org/W2140323904', 'https://openalex.org/W2140983748', 'https://openalex.org/W2142632602', 'https://openalex.org/W2144486959', 'https://openalex.org/W2146455000', 'https://openalex.org/W2148624408', 'https://openalex.org/W2150999725', 'https://openalex.org/W2152119060', 'https://openalex.org/W2152948641', 'https://openalex.org/W2157359173', 'https://openalex.org/W2158226583', 'https://openalex.org/W2158766477', 'https://openalex.org/W2159103570', 'https://openalex.org/W2159446205', 'https://openalex.org/W2161270771', 'https://openalex.org/W2162807572', 'https://openalex.org/W2163772343', 'https://openalex.org/W2164493941', 'https://openalex.org/W2165021720', 'https://openalex.org/W2167423431', 'https://openalex.org/W2167656355', 'https://openalex.org/W2168063913', 'https://openalex.org/W2169028987', 'https://openalex.org/W2170644095', 'https://openalex.org/W2171526610', 'https://openalex.org/W2241215111', 'https://openalex.org/W2406794861', 'https://openalex.org/W4211079490', 'https://openalex.org/W4243693606', 'https://openalex.org/W47487143', 'https://openalex.org/W71980671'], 'related_works': ['https://openalex.org/W383229595', 'https://openalex.org/W345422279', 'https://openalex.org/W2803925928', 'https://openalex.org/W2800250885', 'https://openalex.org/W2572847020', 'https://openalex.org/W2383441779', 'https://openalex.org/W2292512574', 'https://openalex.org/W2258142825', 'https://openalex.org/W2015435909', 'https://openalex.org/W1829912350'], 'abstract_inverted_index': {"Alzheimer's": [0, 31], 'disease': [1, 8, 32, 51], '(AD)': [2, 33], 'is': [3, 23, 34, 85, 103], 'the': [4, 10, 25, 58, 62, 68, 78, 92, 141, 150], '3rd': [5], 'most': [6], 'costly': [7], 'and': [9, 36, 48, 98, 114, 124, 134, 153], 'leading': [11, 27], 'cause': [12, 28], 'of': [13, 29, 91, 155], 'dementia.': [14], 'It': [15], 'can': [16, 39], 'linger': [17, 41], 'for': [18, 149], 'many': [19, 42], 'years,': [20], 'but': [21], 'ultimately': [22], 'fatal,': [24], '6th': [26], 'death.': [30], 'fatal': [35], 'affected': [37], 'individuals': [38], 'sometimes': [40], 'years.': [43], 'Current': [44], 'treatments': [45], 'are': [46], 'palliative': [47], 'transient,': [49], 'not': [50], 'modifying.': [52], 'This': [53], 'article': [54], 'reviews': [55], 'progress': [56], 'in': [57, 111], 'search': [59], 'to': [60, 77, 109, 118, 132], 'identify': [61], 'primary': [63], 'AD-causing': [64], 'toxins.': [65], 'We': [66], 'summarize': [67], 'shift': [69], 'from': [70, 121], 'an': [71], 'initial': [72], 'focus': [73], 'on': [74], 'amyloid': [75], 'plaques': [76], 'contemporary': [79], 'concept': [80], 'that': [81, 96, 105], 'AD': [82], 'memory': [83], 'failure': [84], 'caused': [86], 'by': [87], 'small': [88], 'soluble': [89], 'oligomers': [90, 108], 'Aβ': [93, 107], 'peptide,': [94], 'toxins': [95], 'target': [97], 'disrupt': [99], 'particular': [100], 'synapses.': [101], 'Evidence': [102], 'presented': [104], 'links': [106], 'pathogenesis': [110], 'animal': [112], 'models': [113], 'humans,': [115], 'with': [116], 'reference': [117], 'seminal': [119], 'discoveries': [120], 'cell': [122], 'biology': [123], 'new': [125, 146], 'ideas': [126], 'concerning': [127], 'pathogenic': [128], 'mechanisms,': [129], 'including': [130], 'relationships': [131], 'diabetes': [133], 'Fragile': [135], 'X.': [136], 'These': [137], 'findings': [138], 'have': [139], 'established': [140], 'oligomer': [142], 'hypothesis': [143], 'as': [144], 'a': [145], 'molecular': [147], 'basis': [148], 'cause,': [151], 'diagnosis,': [152], 'treatment': [154], 'AD.': [156]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051268743', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 30}, {'year': 2022, 'cited_by_count': 37}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 33}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 43}, {'year': 2017, 'cited_by_count': 39}, {'year': 2016, 'cited_by_count': 33}, {'year': 2015, 'cited_by_count': 39}, {'year': 2014, 'cited_by_count': 32}, {'year': 2013, 'cited_by_count': 28}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2024-09-18T15:13:24.989342', 'created_date': '2016-06-24'}