Transmembrane Neuregulins Interact with LIM Kinase 1, a Cytoplasmic Protein Kinase Implicated in Development of Visuospatial Cognition

Name: Work Video:
Duration: 3 min 30 s
Jay Y. Wang; Kristen Frenzel; Duanzhi Wen; Douglas L. Falls
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'https://openalex.org/W2027838991', 'https://openalex.org/W2018674819', 'https://openalex.org/W1980792662', 'https://openalex.org/W1980141913', 'https://openalex.org/W1970446746', 'https://openalex.org/W1642220981'], 'abstract_inverted_index': {'The': [0, 189, 379, 1231, 1293, 1576, 2446, 2504, 2541, 2581, 2764, 2868, 2955, 3005, 3079, 3117, 3136, 3458, 3496, 3528, 3591, 3636, 3691, 3718, 3869, 3917, 3989, 4041, 4121, 4142, 4189, 4204, 4220, 4239, 4261, 4338, 4377, 4470, 4495, 4529], 'neuregulins': [1, 32, 116, 190, 221, 306, 380], 'are': [2, 33, 147, 191, 222, 337, 844, 1024, 1382, 1556, 1719, 1758, 1897, 2432, 2438, 2453, 2977, 3028, 3318, 3745], 'receptor': [3, 185, 192, 375, 411, 829, 1241, 1264, 1526, 1532], 'tyrosine': [4, 186, 193, 376, 397, 412, 830, 1242, 1265], 'kinase': [5, 92, 94, 187, 194, 282, 284, 377, 388, 413, 816, 831, 1786], 'ligands': [6, 195, 408, 1718], 'that': [7, 58, 77, 154, 196, 247, 267, 344, 525, 1328, 1354, 1517, 1534, 1772, 1783, 1862, 1894, 2028, 2049, 2431, 2507, 3420, 3685, 3708, 3735, 3742, 3770, 3814], 'play': [8, 159, 197, 349, 2036], 'a': [9, 49, 160, 184, 198, 238, 350, 374, 664, 847, 1155, 1226, 1525, 1531, 1547, 2037, 2514, 2623, 2740, 3045, 3063, 3125, 3186, 3202, 3227, 3231, 3279, 3287, 3444, 3507, 3550, 3556, 3571, 3588, 3609, 3631, 3634, 3660, 3668, 3682, 3764, 3811, 3942, 4082, 4096, 4200, 4233, 4419, 4457, 4557], 'critical': [10, 199], 'role': [11, 161, 200, 351, 2038], 'in': [12, 109, 162, 201, 299, 352, 405, 653, 660, 768, 1367, 1616, 1619, 1871, 1874, 1886, 1916, 2039, 2289, 2455, 2585, 2718, 2859, 2934, 2944, 2979, 3022, 3220, 3272, 3428, 3546, 3625, 3647, 3667, 3756, 3763, 3859, 3911, 4006, 4031, 4037, 4064, 4081, 4146, 4199, 4297, 4306, 4389, 4479, 4522, 4564, 4571], 'the': [13, 16, 29, 40, 43, 61, 67, 78, 84, 89, 99, 120, 132, 150, 172, 180, 202, 205, 218, 229, 232, 250, 256, 268, 274, 279, 289, 310, 322, 340, 362, 370, 410, 527, 561, 658, 661, 1038, 1078, 1083, 1223, 1240, 1255, 1258, 1269, 1283, 1358, 1378, 1393, 1397, 1535, 1550, 1570, 1591, 1623, 1626, 1631, 1709, 1745, 1752, 1764, 1775, 1784, 1856, 1865, 1887, 1900, 1904, 1917, 1920, 2026, 2029, 2040, 2059, 2065, 2069, 2292, 2428, 2433, 2443, 2509, 2587, 2591, 2610, 2614, 2619, 2663, 2667, 2695, 2700, 2727, 2935, 2965, 2970, 2980, 2990, 3016, 3025, 3031, 3039, 3074, 3085, 3143, 3181, 3192, 3198, 3223, 3236, 3251, 3267, 3275, 3293, 3310, 3334, 3361, 3371, 3386, 3394, 3423, 3435, 3465, 3469, 3474, 3504, 3510, 3516, 3519, 3547, 3561, 3567, 3585, 3653, 3673, 3689, 3714, 3721, 3757, 3771, 3776, 3781, 3788, 3791, 3794, 3798, 3801, 3816, 3820, 3840, 3847, 3878, 3912, 3937, 3964, 4025, 4057, 4093, 4102, 4113, 4179, 4305, 4318, 4358, 4526], 'development': [14, 203, 770], 'of': [15, 42, 70, 88, 119, 135, 183, 204, 231, 259, 278, 309, 325, 373, 409, 529, 563, 663, 667, 731, 735, 1020, 1041, 1237, 1257, 1272, 1287, 1296, 1301, 1357, 1377, 1384, 1389, 1392, 1578, 1622, 1712, 1744, 1778, 1907, 1919, 1925, 2031, 2042, 2046, 2287, 2291, 2295, 2427, 2435, 2442, 2520, 2613, 2666, 2742, 2812, 2878, 2883, 2891, 2899, 2973, 3030, 3177, 3197, 3239, 3296, 3315, 3422, 3434, 3518, 3587, 3611, 3633, 3650, 3720, 3790, 3819, 3852, 3905, 3914, 3940, 3975, 4035, 4073, 4099, 4129, 4149, 4166, 4172, 4236, 4249, 4332, 4357, 4392, 4413, 4525], 'heart,': [17, 206], 'nervous': [18, 207, 754, 1889], 'system,': [19, 208, 1890], 'and': [20, 103, 112, 145, 165, 209, 293, 302, 335, 355, 520, 560, 652, 738, 745, 758, 1070, 1221, 1246, 1268, 1335, 1388, 1493, 1533, 1549, 1554, 1567, 1574, 1588, 1599, 1614, 1618, 1630, 1714, 1749, 1864, 1873, 1880, 1891, 2045, 2058, 2389, 2522, 2547, 2590, 2599, 2618, 2674, 2712, 2785, 2831, 2888, 2922, 2964, 2994, 3011, 3038, 3076, 3102, 3156, 3174, 3284, 3317, 3349, 3377, 3383, 3385, 3407, 3473, 3515, 3538, 3565, 3605, 3656, 3732, 3741, 3784, 3857, 3867, 3877, 3928, 3981, 3983, 4046, 4052, 4076, 4111, 4156, 4169, 4178, 4195, 4227, 4276, 4294, 4386, 4399, 4573, 4581], 'breast.': [21, 210], 'Unlike': [22, 211], 'many': [23, 212, 3626], 'extracellular': [24, 213, 1080, 1232, 1260, 1398, 3311], 'signaling': [25, 214, 1160, 1229, 1560, 1580], 'molecules,': [26, 215], 'such': [27, 216], 'as': [28, 35, 217, 224, 521, 1026, 1154, 1222, 1524, 1530, 1546, 2804, 3443, 3883, 3909, 3993, 4314], 'neurotrophins,': [30, 219], 'most': [31, 220], 'synthesized': [34, 223, 1025], 'transmembrane': [36, 72, 225, 261, 836, 1027, 1033, 1518, 3526], 'proteins.': [37, 226, 3135, 3325], 'To': [38, 167, 227, 357, 2985, 3179, 3242, 3326, 3365], 'determine': [39, 228, 1751], 'functions': [41, 230, 730, 1376, 1743, 1757, 1906], 'highly': [44, 233], 'conserved': [45, 234], 'neuregulin': [46, 73, 79, 100, 123, 144, 235, 262, 269, 290, 313, 334, 811, 2057], 'cytoplasmic': [47, 68, 80, 101, 124, 133, 181, 236, 257, 270, 291, 314, 323, 371, 1360, 1380, 1537, 1710, 1730, 1747, 1776, 1858, 1867, 2616, 2669, 2996, 3246, 3298, 3304, 3324, 3387, 3521], 'tail,': [48, 237, 2617], 'yeast': [50, 239, 1765, 2542, 2987, 3253, 3372, 3459, 3475, 3707, 3722, 3809, 3854, 3870, 3924, 3968], 'two-hybrid': [51, 240, 1766, 2543, 3254, 3373, 3460, 3529, 3669, 3723], 'screen': [52, 75, 241, 265, 3748, 3759], 'was': [53, 106, 242, 296, 1594, 2513, 2692, 2730, 2739, 2770, 2839, 2872, 2958, 3059, 3081, 3120, 3139, 3170, 3189, 3213, 3390, 3533, 3579, 3596, 3606, 3805, 3881, 3907, 3923, 3991, 4022, 4067, 4089, 4104, 4123, 4181, 4206, 4222, 4230, 4243, 4341, 4361, 4416, 4425], 'performed': [54, 243, 3882, 3992], 'to': [55, 66, 177, 244, 255, 367, 766, 1076, 1739, 1750, 1768, 2064, 2866, 2896, 2969, 2982, 3050, 3122, 3130, 3321, 3451, 3524, 3599, 3619, 3768, 3786, 3832, 3945, 4092, 4095, 4183, 4224, 4232, 4433, 4441, 4451], 'identify': [56, 245], 'proteins': [57, 246, 1028, 1726, 1771, 1896, 2066, 2281, 2297, 2307, 3027, 3053, 3306, 3421, 3657, 4447], 'interact': [59, 139, 178, 248, 329, 368, 1773, 3666], 'with': [60, 83, 117, 128, 140, 179, 249, 273, 307, 318, 330, 369, 1262, 1728, 1774, 1855, 2033, 2821, 2913, 2925, 2941, 2960, 3054, 3230, 3286, 3381, 3432, 3688, 3713, 3780, 3793, 3839, 3926, 4126, 4186, 4246, 4274, 4278, 4317, 4329, 4367, 4383, 4397, 4427, 4474, 4503, 4535, 4556], '157-amino': [62, 251], 'acid': [63, 252, 813, 1298], 'sequence': [64, 253, 1299, 3041, 3827], 'common': [65, 254, 2611, 2664, 3523], 'tails': [69, 258, 1711, 1731], 'all': [71, 260, 3525], 'isoforms.This': [74], 'revealed': [76, 266], 'tail': [81, 102, 125, 134, 182, 271, 292, 315, 324, 372, 1361, 1381, 1538, 1748, 1777, 1868, 2670, 3299, 3305, 3522], 'interacts': [82, 272, 1854, 3779], 'LIM': [85, 93, 275, 283, 390, 815, 819], 'domain': [86, 276, 391, 820, 1081, 1236, 1261, 3035, 3314, 3514, 3684, 3818, 3939, 3943], 'region': [87, 277, 821, 1286, 1304, 2612, 2665], 'nonreceptor': [90, 280, 1785], 'protein': [91, 175, 281, 365, 842, 1161, 1386, 2429, 3229, 3281, 3369, 3552, 3568, 3622, 3655, 3663, 3675, 3823, 3826, 4049, 4370], '1': [95, 285, 817, 4139, 4170, 4256, 4490], '(LIMK1).': [96, 286], 'Interaction': [97, 287], 'between': [98, 288, 1563, 1581, 1625, 3172, 3509, 3652], 'full-length': [104, 294, 2510, 3183, 3240, 3331, 3661, 3674], 'LIMK1': [105, 146, 170, 295, 336, 360, 818, 1787, 1863, 1881, 1908, 1911, 2032, 2512, 3184, 3193, 3211, 4424], 'demonstrated': [107, 297], 'by': [108, 298, 1275, 1597, 1721, 1754, 2068, 2299, 2553, 2596, 2874, 3000, 3061, 3083, 3141, 3404, 3408, 3535, 3570, 4193, 4208, 4265, 4343], 'vitro': [110, 300, 651, 1620, 1872, 4298, 4307], 'binding': [111, 301, 3034, 3513, 4299, 4308], 'co-immunoprecipitation': [113, 303], 'assays.': [114, 304], 'Transmembrane': [115, 305], 'each': [118, 308, 2860, 3297, 3433], 'three': [121, 311, 4381], 'known': [122, 312, 3830, 3944], 'isoforms': [126, 316, 843, 1023, 1289, 2430, 2452], 'interacted': [127, 317], 'LIMK1.': [129, 141, 319, 331, 3241], 'In': [130, 142, 320, 332, 650, 1277, 1877], 'contrast,': [131, 321, 1278], 'TGF-α': [136, 326, 2995], 'did': [137, 327], 'not': [138, 328, 1522, 3308, 3665], 'vivo,': [143, 333, 1878], 'co-localized': [148, 338, 1898], 'at': [149, 339, 760, 1899, 2699, 4078, 4117, 4210, 4217, 4258, 4267, 4345, 4352, 4364, 4401, 4492, 4500, 4548], 'neuromuscular': [151, 341, 1901, 2043], 'synapse,': [152, 342], 'suggesting': [153, 343], 'LIMK1,': [155, 345], 'like': [156, 346], 'neuregulin,': [157, 347], 'may': [158, 348, 1151, 1520, 2035, 3628, 3644], 'synapse': [163, 353, 736], 'formation': [164, 354, 737, 2041], 'maintenance.': [166, 356], 'our': [168, 358, 2719], 'knowledge,': [169, 359], 'is': [171, 361, 1035, 1516, 3617, 3676], 'first': [173, 363, 1595, 2070, 3592], 'identified': [174, 364, 404], 'shown': [176, 366], 'ligand.': [188, 378], 'isoforms.': [263], 'This': [264, 3168, 3209, 3577, 3615, 3825], '(NRGs)': [381], '1The': [382], 'abbreviations': [383], 'used': [384, 1763, 2693, 3121, 3501, 3725, 4295], 'are:': [385], 'NRGneuregulinCAPS3-(cyclohexylamino)-1-propanesulfonic': [386], 'acidGSTglutathioneS-transferaseLIMK1LIM': [387], '1LIMK1-ldrLIMK1': [389], 'regionPBSphosphate-buffered': [392], 'salinePCRpolymerase': [393], 'chain': [394, 825, 3002], 'reactionPVDFpolyvinylidene': [395], 'difluorideRTKreceptor': [396], 'kinaseTGF-αtransforming': [398], 'growth': [399, 567, 833, 1234, 2962], 'factor': [400, 834], 'αTMtransmembraneAbantibody.': [401], 'were': [402, 2551, 2594, 2622, 2680, 2704, 2788, 2803, 2848, 2857, 2911, 2938, 2967, 2998, 3008, 3264, 3356, 3379, 3402, 3426, 3703, 3760, 3843, 3855, 3872, 3970, 4054, 4115, 4144, 4176, 4191, 4263, 4312, 4323, 4379, 4431, 4448, 4472, 4497, 4531, 4554], 'originally': [403], 'searches': [406], 'for': [407, 1225, 1708, 2694, 2782, 2800, 2837, 2931, 2952, 3330, 3502, 3608, 3658, 3920, 4085, 4106, 4160, 4214, 4255, 4296, 4349, 4404, 4436, 4489], 'erbB2': [414], '(1Peles': [415, 2074], 'E.': [416, 446, 2075, 2105, 2517], 'Bacus': [417, 451, 2076, 2110], 'S.S.': [418, 452, 984, 2077, 2111], 'Koski': [419, 463, 936, 1434, 2078, 2122, 2489], 'R.A.': [420, 464, 937, 1435, 2079, 2123, 2490], 'Lu': [421, 465, 926, 1424, 2080, 2124, 2479], 'H.S.': [422, 466, 927, 958, 1112, 1425, 2081, 2125, 2480], 'Wen': [423, 1131, 2082], 'D.': [424, 444, 494, 612, 618, 640, 772, 866, 872, 894, 909, 931, 935, 1051, 1092, 1126, 1132, 1407, 1429, 1433, 1456, 1637, 2002, 2012, 2083, 2103, 2153, 2242, 2248, 2270, 2392, 2462, 2484, 2488, 2640], 'Ogden': [425, 2084], 'S.G.': [426, 2085], 'Levy': [427, 461, 2086, 2120], 'R.B.': [428, 462, 2087, 2121, 2752], 'Yarden': [429, 467, 683, 938, 1436, 2088, 2126, 2491], 'Y.': [430, 454, 468, 684, 915, 939, 998, 1049, 1090, 1413, 1437, 1454, 2089, 2113, 2127, 2402, 2468, 2492, 2638], 'Cell.': [431, 469, 548, 941, 1315, 1439, 1481, 1504, 1648, 1960, 2090, 2128, 2189, 2379, 2494, 2569, 3484, 3892], '1992;': [432, 470, 512, 1482, 2091, 2129, 2171], '69:': [433, 471, 2092, 2130], '205-216Abstract': [434, 2093], 'Full': [435, 473, 552, 591, 689, 691, 967, 969, 1009, 1011, 1060, 1062, 1101, 1103, 1139, 1141, 1211, 1213, 1319, 1465, 1467, 1485, 1652, 1654, 1964, 1966, 1981, 1983, 2094, 2132, 2193, 2221, 2573, 2649, 2651, 3488, 3896], 'Text': [436, 474, 553, 592, 690, 692, 968, 970, 1010, 1012, 1061, 1063, 1102, 1104, 1140, 1142, 1212, 1214, 1320, 1466, 1468, 1486, 1653, 1655, 1965, 1967, 1982, 1984, 2095, 2133, 2194, 2222, 2574, 2650, 2652, 3489, 3897], 'PDF': [437, 475, 554, 593, 693, 971, 1013, 1064, 1105, 1143, 1215, 1321, 1469, 1487, 1656, 1968, 1985, 2096, 2134, 2195, 2223, 2575, 2653, 3490, 3898], 'PubMed': [438, 476, 515, 555, 594, 645, 676, 694, 709, 724, 779, 806, 899, 946, 972, 992, 1014, 1065, 1106, 1144, 1173, 1188, 1216, 1322, 1347, 1444, 1470, 1488, 1508, 1609, 1657, 1678, 1693, 1833, 1969, 1986, 2018, 2097, 2135, 2174, 2196, 2224, 2275, 2332, 2351, 2384, 2421, 2499, 2536, 2576, 2654, 2759, 3491, 3899, 3958], 'Scopus': [439, 477, 516, 556, 646, 677, 695, 710, 725, 780, 807, 900, 947, 973, 1015, 1066, 1107, 1145, 1174, 1189, 1217, 1323, 1348, 1445, 1471, 1489, 1509, 1610, 1658, 1679, 1694, 1834, 1970, 1987, 2019, 2098, 2136, 2175, 2197, 2276, 2333, 2352, 2385, 2422, 2500, 2537, 2577, 2655, 2760, 3492, 3900, 3959], '(478)': [440, 2099], 'Google': [441, 479, 518, 558, 595, 648, 679, 697, 712, 727, 782, 809, 902, 949, 975, 993, 1017, 1068, 1109, 1147, 1176, 1191, 1219, 1325, 1350, 1447, 1473, 1491, 1511, 1612, 1660, 1681, 1696, 1802, 1822, 1836, 1852, 1972, 1989, 2021, 2100, 2138, 2177, 2199, 2225, 2278, 2335, 2354, 2387, 2424, 2502, 2539, 2579, 2657, 2762, 3494, 3902, 3961], 'Scholar,': [442, 480, 680, 698, 713, 783, 903, 950, 976, 994, 1110, 1177, 1192, 1448, 1474, 1492, 1661, 1682, 1803, 1823, 1837, 1973, 1990, 2101, 2139, 2178, 2200, 2226, 2336, 2355], '2Wen': [443, 2102], 'Peles': [445, 2104], 'Cupples': [447, 912, 1410, 2106, 2465], 'R.': [448, 785, 1647, 1688, 1795, 1845, 2107, 2400, 4001], 'Suggs': [449, 906, 1404, 2108, 2459], 'S.V.': [450, 907, 1405, 2109, 2460], 'Luo': [453, 914, 1412, 2112, 2467], 'Trail': [455, 1121, 2114], 'G.': [456, 543, 717, 1122, 1310, 1667, 1793, 2115, 2184, 2398], 'Hu': [457, 928, 1052, 1093, 1129, 1426, 1457, 2116, 2481, 2641], 'S.': [458, 682, 801, 929, 1053, 1094, 1114, 1128, 1130, 1338, 1427, 1458, 1602, 1791, 2117, 2416, 2482, 2554, 2642, 4003], 'Silbiger': [459, 2118], 'S.M.': [460, 2119, 2566, 3481, 3889], '559-572Abstract': [472, 2131], '(526)': [478, 2137], '3Holmes': [481, 2140], 'W.E.': [482, 2141], 'Sliwkowski': [483, 2142, 2393], 'M.X.': [484, 2143, 2394], 'Akita': [485, 2144, 2399], 'R.W.': [486, 2145], 'Henzel': [487, 2146], 'W.J.': [488, 2147], 'Lee': [489, 1500, 2148], 'J.': [490, 585, 614, 868, 961, 987, 1054, 1095, 1133, 1165, 1179, 1341, 1459, 1480, 1643, 1937, 2149, 2215, 2244, 2321, 2373, 2408, 2643, 2753], 'Park': [491, 2150], 'J.W.': [492, 2151], 'Yansura': [493, 2152], 'Abadi': [495, 2154], 'N.': [496, 787, 919, 1417, 2155, 2323, 2472, 2600, 3536], 'Raab': [497, 2156], 'H.': [498, 2157, 2338], 'Lewis': [499, 2158], 'G.D.': [500, 547, 700, 1314, 1669, 2159, 2188], 'Shepard': [501, 2160], 'H.M.': [502, 2161], 'Kuang': [503, 2162], 'W.-J.': [504, 2163], 'Wood': [505, 2164], 'W.I.': [506, 2165], 'Goeddel': [507, 2166], 'D.V.': [508, 2167], 'Vandlen': [509, 2168], 'R.L.': [510, 913, 1411, 2169, 2466], 'Science.': [511, 1689, 2170], '256:': [513, 2172], '1205-1210Crossref': [514, 2173], '(925)': [517, 2176], 'Scholar)': [519, 559, 1220, 1326, 1351, 1697, 1853, 2388], 'neuronally': [522], 'produced': [523, 845, 2439, 3427], 'factors': [524], 'stimulate': [526], 'synthesis': [528, 3595], 'muscle': [530], 'acetylcholine': [531], 'receptors': [532], '(acetylcholine': [533], 'receptor-inducing': [534], 'activity;': [535], 'see': [536, 569], 'Ref.': [537, 2456], '4Falls': [538, 2179], 'D.L.': [539, 1306, 1955, 2180], 'Rosen': [540, 701, 1307, 2181], 'K.M.': [541, 702, 1308, 2182], 'Corfas': [542, 1309, 2183], 'Lane': [544, 1311, 2185], 'W.S.': [545, 1312, 2186], 'Fischbach': [546, 1313, 2187], '1993;': [549, 588, 642, 896, 1170, 1185, 1316, 2190, 2218, 2272, 2570, 3485, 3893, 3955], '72:': [550, 1317, 2191], '801-815Abstract': [551, 1318, 2192], '(554)': [557, 1324, 2198], 'proliferation': [562], 'Schwann': [564], 'cells': [565, 1043, 1564, 1568, 1582, 1589, 2802, 2847, 2856, 3430, 4311], '(glial': [566], 'factor;': [568], 'Refs.': [570, 1401], '5Goodearl': [571, 2201], 'A.': [572, 802, 956, 1181, 1478, 1604, 2202, 2417], 'Davis': [573, 625, 879, 2203, 2255], 'J.B.': [574, 626, 880, 2204, 2256], 'Mistry': [575, 2205], 'K.': [576, 616, 870, 1200, 1684, 1805, 1809, 1811, 1813, 1994, 2206, 2246, 2404, 2750], 'Minghetti': [577, 2207], 'L.': [578, 1004, 2208], 'Otsu': [579, 631, 885, 2209, 2261], 'M.': [580, 608, 622, 632, 715, 862, 876, 886, 1635, 1671, 1847, 1953, 1992, 2210, 2238, 2252, 2262, 2325, 2396, 3953], 'Waterfield': [581, 635, 889, 2211, 2265], 'M.D.': [582, 636, 890, 1118, 2212, 2266], 'Stroobant': [583, 637, 891, 2213, 2267], 'P.': [584, 638, 892, 1000, 1340, 2214, 2268], 'Biol.': [586, 942, 962, 1055, 1096, 1134, 1169, 1440, 1460, 1503, 1977, 2216, 2380, 2495, 2644, 2755], 'Chem.': [587, 963, 1056, 1097, 1135, 1461, 2217, 2645], '268:': [589, 2219], '18095-18102Abstract': [590, 2220], 'Scholar': [596], 'and6Marchionni': [597], 'M.A.': [598, 852, 1202, 1497, 2228], 'Goodearl': [599, 853, 2229, 2374], 'A.D.J.': [600, 854, 2230, 2375], 'Chen': [601, 855, 2231], 'M.S.': [602, 856, 2232], 'Bermingham-McDonogh': [603, 857, 2233], 'O.': [604, 858, 1789, 2234], 'Kirk': [605, 859, 2235], 'C.': [606, 620, 774, 860, 874, 1002, 1839, 1949, 2006, 2236, 2250, 2327, 2406, 2597, 3539], 'Hendricks': [607, 861, 2237], 'Danehy': [609, 863, 2239], 'F.': [610, 864, 2240], 'Misumi': [611, 865, 2241], 'Sudhalter': [613, 867, 2243], 'Kobayashi': [615, 869, 2245], 'Wroblewski': [617, 871, 2247], 'Lynch': [619, 873, 2249], 'Baldassare': [621, 875, 2251], 'Hiles': [623, 877, 2253], 'I.': [624, 878, 1198, 1807, 2254, 3951], 'Hsuan': [627, 881, 2257], 'J.J.': [628, 882, 2258], 'Totty': [629, 883, 2259], 'N.F.': [630, 884, 2260], 'McBurney': [633, 887, 2263], 'R.N.': [634, 888, 2264], 'Gwynne': [639, 893, 2269], 'Nature.': [641, 775, 895, 1605, 1674, 2271, 2328, 2347, 3954], '362:': [643, 897, 2273], '312-318Crossref': [644, 898, 2274], '(681)': [647, 901, 2277], 'Scholar).': [649, 728, 810, 1018, 1148, 1512, 2022, 2279, 2425, 2540, 2580, 2658, 2763, 3495, 3903, 3962, 4018], 'vivo': [654, 1617], 'studies': [655, 1251, 1621], 'now': [656, 2283], 'implicate': [657], 'NRGs': [659, 732], 'regulation': [662, 734, 1383], 'large': [665], 'number': [666, 3341, 3347, 3354], 'biological': [668, 1270, 1332, 1375, 1706], 'processes': [669], '(7Carraway': [670], 'K.L.': [671, 2315], 'BioEssays.': [672], '1996;': [673, 803, 1208, 1649, 1675, 1961, 1978, 2015], '18:': [674, 687], '263-266Crossref': [675], '(33)': [678], '8Burden': [681], 'Neuron.': [685, 1005, 1207], '1997;': [686, 706, 721, 989, 1344, 1505, 1690, 2329, 2348, 2381, 2418], '847-855Abstract': [688], '(422)': [696], '9Fischbach': [699], 'Annu.': [703, 1182], 'Rev.': [704, 1183], 'Neurosci.': [705, 988], '20:': [707, 1007], '429-458Crossref': [708], '(254)': [711], '10Gassmann': [714], 'Lemke': [716], 'Curr.': [718, 1166, 1976], 'Opin.': [719, 1167], 'Neurobiol.': [720], '7:': [722], '87-92Crossref': [723], '(108)': [726], 'Known': [729], 'include': [733, 3309], 'maintenance,': [739], 'cell': [740, 1039, 4339, 4359], 'proliferation,': [741], 'apoptosis,': [742], 'differentiation': [743], 'decisions,': [744], 'neuronal': [746, 2047], 'migration.': [747], 'Transgenic': [748], 'knockout': [749], 'mice': [750], 'lacking': [751, 3739, 3863, 3977], 'NRG': [752, 841, 849, 1022, 1079, 1250, 1259, 1359, 1379, 1385, 1394, 1519, 1536, 1544, 1713, 1746, 1857, 1866, 1879, 2034, 2061, 2072, 2302, 2451, 2615, 2668, 2728, 3245, 3303, 3316, 3520], 'have': [753, 1252, 1698, 1732, 1762, 1882, 2308, 2714], 'system': [755, 1767, 3724, 4577], 'developmental': [756], 'defects': [757], 'die': [759], 'mid-embryogenesis': [761], '(embryonic': [762], 'days': [763], '10–11)': [764], 'due': [765, 3450], 'abnormalities': [767], 'heart': [769], '(11Meyer': [771], 'Birchmeier': [773], '1995;': [776, 964, 1057, 1098, 1136, 1462, 1830, 1849, 2533, 2646], '378:': [777], '386-390Crossref': [778], '(1058)': [781], '12Kramer': [784], 'Bucay': [786], 'Kane': [788], 'D.J.': [789, 1206, 2340], 'Martin': [790], 'L.E.': [791, 795], 'Tarpley': [792], 'J.E.': [793], 'Theill': [794], 'Proc.': [796, 2411], 'Natl.': [797, 2412], 'Acad.': [798, 2413], 'Sci.': [799, 2414], 'U.': [800, 2415], '93:': [804], '4833-4838Crossref': [805], '(190)': [808], '3-(cyclohexylamino)-1-propanesulfonic': [812], 'glutathioneS-transferase': [814], 'phosphate-buffered': [822], 'saline': [823], 'polymerase': [824, 3001], 'reaction': [826, 3003], 'polyvinylidene': [827, 4452], 'difluoride': [828, 4453], 'transforming': [832], 'α': [835], 'antibody.': [837], 'At': [838], 'least': [839], '15': [840, 4161, 4350, 4411], 'from': [846, 2440, 2516, 2625, 2682, 2732, 2772, 2790, 3250, 3581, 3584, 3640, 3753, 3775], 'single': [848], 'gene': [850, 2073], '(6Marchionni': [851], '13Wen': [904, 1402, 2457], 'D.Z.': [905, 1403, 2458], 'Karunagaran': [908, 1406, 2461], 'Liu': [910, 1408, 2463], 'N.L.': [911, 1409, 2464], 'Janssen': [916, 1414, 2469], 'A.M.': [917, 1415, 2470], 'Benbaruch': [918, 1416, 2471], 'Trollinger': [920, 1418, 2473], 'D.B.': [921, 1419, 2474], 'Jacobsen': [922, 1420, 2475], 'V.L.': [923, 1421, 2476], 'Meng': [924, 1422, 2477], 'S.Y.': [925, 1423, 2478], 'Chang': [930, 1428, 2483], 'Yang': [932, 1430, 2485], 'W.N.': [933, 1431, 2486], 'Yanigahara': [934, 1432, 2487], 'Mol.': [940, 1438, 1502, 2378, 2493], '1994;': [943, 1441, 1799, 1819, 2496], '14:': [944, 1442, 2497], '1909-1919Crossref': [945, 1443, 2498], '(234)': [948, 1446, 2501], '14Ho': [951], 'W.-H.': [952], 'Armanini': [953], 'M.P.': [954], 'Nuijens': [955], 'Phillips': [957], 'Osheroff': [959], 'P.L.': [960, 3997], '270:': [965, 1058, 1099, 1137, 1463, 2647], '14523-14532Abstract': [966], '(130)': [974], '15Carroll': [977], 'S.L.': [978, 1047, 1088, 1452, 2636], 'Miller': [979], 'M.L.': [980, 1499], 'Frohnert': [981], 'P.W.': [982], 'Kim': [983], 'Corbett': [985], 'J.A.': [986, 2568, 3483, 3891], '17:': [990, 2382], '1642-1659Crossref': [991], '16Yang': [995], 'X.': [996, 2010], 'Kuo': [997], 'Devay': [999], 'Yu': [1001, 2322], 'Role': [1003], '1998;': [1006], '255-270Abstract': [1008], '(123)': [1016], 'Most': [1019, 1248], 'these': [1021, 1263, 1729, 1741, 1756, 1895, 2702], '(see': [1029, 1290, 1400, 3574], 'Fig.': [1030, 1291, 2983, 3023, 3221, 3273, 3455, 3575, 3915], '1).': [1031, 1292], 'Full-length': [1032], '(TM)-NRG': [1034], 'found': [1036], 'on': [1037, 1254, 1282, 3446, 3737, 3861, 4158, 4372, 4418, 4443], 'surface': [1040], 'TM-NRG-expressing': [1042], '(17Burgess': [1044, 1085, 2633], 'T.L.': [1045, 1086, 1450, 2363, 2634], 'Ross': [1046, 1087, 1451, 2635], 'Qian': [1048, 1089, 1453, 2637], 'Brankow': [1050, 1091, 1125, 1455, 2639], '19188-19196Abstract': [1059, 1100, 1464, 2648], '(83)': [1067, 1108, 1472, 2656], 'Scholar),': [1069, 1613], 'TM-NRG': [1071, 1150, 1288, 1566], 'can': [1072, 1364], 'be': [1073, 2284, 3322, 3645], 'proteolytically': [1074], 'processed': [1075], 'release': [1077, 1391], 'into': [1082, 1396, 3013, 3067, 3191, 3216, 3266, 3358, 3393, 3705, 3807, 3972, 4056, 4070], 'medium': [1084, 2810, 2816, 2903, 2919, 2949, 2957, 3738, 3862, 3976, 4066], '18Lu': [1111], 'Hara': [1113], 'Wong': [1115], 'L.W.-I.': [1116], 'Jones': [1117, 1199], 'Katta': [1119], 'V.': [1120], 'Zou': [1123], 'A.H.': [1124], 'Cole': [1127], '4775-4783Abstract': [1138], '(38)': [1146], 'Thus,': [1149, 1703], 'act': [1152], 'both': [1153, 3932], 'juxtacrine': [1156], '(direct': [1157], 'cell-cell': [1158], 'contact)': [1159], '(19Bosenberg': [1162], 'M.W.': [1163, 1476], 'Massagué': [1164, 1479], 'Cell': [1168, 1796, 2754], '5:': [1171, 1800], '832-838Crossref': [1172], '(67)': [1175], '20Massagué': [1178], 'Pandiella': [1180, 1477], 'Biochem.': [1184], '62:': [1186], '515-541Crossref': [1187], '(600)': [1190], '21Verdi': [1193], 'J.M.': [1194, 1929], 'Groves': [1195], 'A.K.': [1196, 1825, 1931, 2528], 'Farinas': [1197], 'Marchionni': [1201], 'Reichardt': [1203], 'L.F.': [1204], 'Anderson': [1205], '16:': [1209], '515-527Abstract': [1210], '(119)': [1218], 'precursor': [1224], 'diffusible,': [1227], 'paracrine': [1228], 'molecule.': [1230], 'epidermal': [1233], 'factor-like': [1235], 'TM-NRGs': [1238, 3440], 'activates': [1239], 'kinases': [1243, 1266], 'erbB2,': [1244, 1552, 1572], 'erbB3,': [1245, 1553, 1573], 'erbB4.': [1247, 1575], 'prior': [1249, 2865, 4440], 'focused': [1253, 1281], 'interaction': [1256, 1624, 2030, 3687, 3792, 3838, 3906], '(RTKs)': [1267], 'consequences': [1271], 'erbB2/erbB3/erbB4': [1273], 'activation': [1274], 'NRG.': [1276, 1779, 3833], 'this': [1279, 1302, 1701, 2055, 2436, 3641, 3921, 4414], 'study': [1280, 2437], 'long': [1284], 'intracellular': [1285, 1303], 'high': [1294], 'degree': [1295], 'amino': [1297], 'conservation': [1300], '(4Falls': [1305], 'suggests': [1327], 'it': [1329, 3680], 'has': [1330, 1913, 3828], 'important': [1331], 'functions.': [1333, 2053], 'Grimm': [1334], 'Leder': [1336, 1339], '(22Grimm': [1337], 'Exp.': [1342], 'Med.': [1343], '185:': [1345], '1137-1142Crossref': [1346], '(34)': [1349], 'recently': [1352], 'reported': [1353, 3462], 'one': [1355], 'form': [1356], '(the': [1362], 'b-tail)': [1363], 'activate': [1365], 'apoptosis': [1366], 'TM-NRG-transfected': [1368], 'HEK': [1369], '293': [1370], 'cells.': [1371, 1876], 'Two': [1372], 'other': [1373, 1715, 2301], 'potential': [1374, 1705, 1742], 'trafficking': [1387], 'proteolytic': [1390], 'ectodomain': [1395], 'space': [1399], '17Burgess': [1449], '23Bosenberg': [1475], '71:': [1483], '1157-1165Abstract': [1484], '(109)': [1490], '24Briley': [1494], 'G.P.': [1495], 'Hissong': [1496], 'Chiu': [1498], 'D.C.': [1501], '8:': [1506], '1619-1631Crossref': [1507], '(69)': [1510], 'Another': [1513], 'intriguing': [1514], 'possibility': [1515, 2027], 'function': [1521], 'only': [1523, 2063, 3630], 'ligand': [1527, 1587, 1628], 'but': [1528], 'also': [1529, 2661], 'mediates': [1539, 2050], 'outside-in': [1540], 'signal': [1541], 'transduction.': [1542], 'If': [1543], 'acts': [1545], '"receptor"': [1548], 'RTKs': [1551, 1571], 'erbB4': [1555], 'its': [1557], '"ligand,"': [1558], 'bi-directional': [1559, 1579], 'could': [1561], 'occur': [1562], 'expressing': [1565, 1569, 1583, 1590], 'idea': [1577], 'an': [1584, 1737, 3055, 3934, 4107], 'RTK': [1585, 1593, 1632, 1716], 'TM': [1586, 1627, 1717, 3313], 'cognate': [1592], 'suggested': [1596], 'Pfeffer': [1598], 'Ullrich': [1600, 1603], '(25Pfeffer': [1601], '1985;': [1606, 2756], '313:': [1607], '184Crossref': [1608], '(50)': [1611], 'recent': [1615, 2293], 'LERK-2': [1629], 'Nuk': [1633], '(26Henkemeyer': [1634], 'Orioli': [1636], 'Henderson': [1638], 'J.T.': [1639], 'Saxton': [1640], 'T.M.': [1641], 'Roder': [1642], 'Pawson': [1644, 1672], 'T.': [1645, 1673, 1815, 1817, 2626], 'Klein': [1646, 1687, 1940], '86:': [1650, 1962], '35-46Abstract': [1651], '(465)': [1659], '27Holland': [1662], 'S.J.': [1663, 1957, 2357], 'Gale': [1664], 'N.W.': [1665], 'Mbamalu': [1666], 'Yancopoulos': [1668], 'Henkemeyer': [1670], '383:': [1676], '722-725Crossref': [1677], '(462)': [1680], '28Bruckner': [1683], 'Pasquale': [1685], 'E.B.': [1686], '275:': [1691], '1640-1643Crossref': [1692], '(348)': [1695], 'strongly': [1699, 3946], 'supported': [1700, 1720], 'hypothesis.': [1702], 'several': [1704], 'roles': [1707], 'experimental': [1722], 'evidence;': [1723], 'however,': [1724], 'no': [1725, 3829, 3837], 'interacting': [1727], 'been': [1733, 1914, 2309, 3711], 'molecularly': [1734], 'identified.': [1735], 'As': [1736, 3020, 3218, 3270], 'approach': [1738], 'assessing': [1740], 'mechanism': [1753], 'which': [1755, 3659, 3931], 'carried': [1759], 'out,': [1760], 'we': [1761, 1892], 'isolate': [1769], 'brain': [1770, 2583, 3572, 3586], 'We': [1780, 1860], 'report': [1781], 'evidence': [1782], '(29Bernard': [1788], 'Ganiatsas': [1790], 'Kannourakis': [1792], 'Dringen': [1794], 'Growth': [1797], 'Differ.': [1798], '1159-1171PubMed': [1801], '30Mizuno': [1804], 'Okano': [1806], 'Ohashi': [1808], 'Nunoue': [1810], 'Kuma': [1812], 'Miyata': [1814], 'Nakamura': [1816], 'Oncogene.': [1818, 1848], '9:': [1820], '1605-1612PubMed': [1821], '31Cheng': [1824], 'Robertson': [1826, 2518, 2529], 'E.J.': [1827, 2530], 'Mech.': [1828, 2531], 'Dev.': [1829, 2532], '52:': [1831, 2534], '187-197Crossref': [1832, 2535], '(47)': [1835, 2538], '32Pröschel': [1838], 'Blouin': [1840], 'M.J.': [1841, 2319], 'Gutowski': [1842, 1950, 2007], 'N.J.': [1843, 1951, 2008], 'Ludwig': [1844], 'Noble': [1846, 1952], '11:': [1850], '1271-1281PubMed': [1851], 'tail.': [1859], 'show': [1861, 1893], 'physically': [1869], 'associate': [1870], 'cultured': [1875], 'overlapping': [1883], 'expression': [1884, 3047, 3127, 3328, 3437, 3530, 4043, 4320], 'patterns': [1885], 'mammalian': [1888, 3046, 3126, 3436], 'synapse.': [1902], 'Although': [1903], 'cellular': [1905], 'remain': [1909], 'unknown,': [1910], 'hemizygosity': [1912], 'implicated': [1915], 'pathogenesis': [1918], 'visuospatial': [1921], 'constructive': [1922], 'cognitive': [1923, 2052], 'defect': [1924], 'Williams': [1926], 'syndrome': [1927], '(33Frangiskakis': [1928], 'Ewart': [1930], 'Morris': [1932], 'C.A.': [1933, 2369], 'Mervis': [1934], 'C.B.': [1935], 'Bertrand': [1936], 'Robinson': [1938], 'B.F.': [1939], 'B.P.': [1941], 'Ensing': [1942], 'G.J.': [1943], 'Everett': [1944], 'L.A.': [1945], 'Green': [1946], 'E.D.': [1947], 'Proschel': [1948, 2005], 'Atkinson': [1954], 'Odelberg': [1956], 'Keating': [1958], 'M.T.': [1959], '59-69Abstract': [1963], '(475)': [1971], '34Monaco': [1974], 'A.P.': [1975, 2004], '6:': [1979], '1396-1398Abstract': [1980], '(17)': [1988], '35Tassabehji': [1991], 'Metcalfe': [1993], 'Fergusson': [1995], 'W.D.': [1996], 'Carette': [1997], 'M.J.A.': [1998], 'Dore': [1999], 'J.K.': [2000], 'Donnai': [2001], 'Read': [2003], 'Mao': [2009], 'Sheer': [2011], 'Nat.': [2013], 'Genet.': [2014], '13:': [2016], '272-273Crossref': [2017], '(98)': [2020], 'Our': [2023], 'findings': [2024], 'suggest': [2025], 'synapses': [2044], 'circuitry': [2048], 'specific': [2051], 'Throughout': [2054], 'paper,': [2056], 'abbreviation': [2060], 'refer': [2062], 'encoded': [2067, 2298, 3569], 'discovered': [2071], '6Marchionni': [2227], 'These': [2280, 2305, 3301], 'might': [2282], 'considered': [2285, 3746], 'forms': [2286], 'NRG1': [2288, 2444], 'light': [2290], 'discovery': [2294], 'related': [2296], 'two': [2300, 3086, 3727], 'family': [2303], 'genes.': [2304], 'NRG1-related': [2306], 'dubbed': [2310], 'NRG2': [2311], '(or': [2312], 'Don-1)': [2313], '(36Carraway': [2314], 'Weber': [2316], 'J.L.': [2317], 'Unger': [2318], 'Ledesma': [2320], 'Gassmann': [2324], 'Lai': [2326], '387:': [2330, 2349], '512-516Crossref': [2331], '(342)': [2334], '37Chang': [2337], 'Riese': [2339], 'Gilbert': [2341], 'W.': [2342], 'Stern': [2343], 'D.F.': [2344], 'McMahan': [2345], 'U.J.': [2346], '509-512Crossref': [2350], '(256)': [2353], '38Busfield': [2356], 'Michnick': [2358], 'D.A.': [2359, 4012], 'Chickering': [2360], 'T.W.': [2361], 'Revett': [2362], 'Ma': [2364], 'J.Y.': [2365], 'Woolf': [2366, 2372], 'E.A.': [2367], 'Comrack': [2368], 'Dussault': [2370], 'B.J.': [2371], 'Gearing': [2376], 'D.P.': [2377], '4007-4014Crossref': [2383], '(106)': [2386], 'NRG3': [2390], '(39Zhang': [2391], 'Mark': [2395], 'Frantz': [2397], 'Sun': [2401], 'Hillan': [2403], 'Crowley': [2405], 'Brush': [2407], 'Godowski': [2409], 'P.J.': [2410], '94:': [2419], '9562-9567Crossref': [2420], '(328)': [2423], 'All': [2426, 2779, 3400], 'subject': [2434], 'transcripts': [2441], 'gene.': [2445], 'cDNA': [2447, 2505, 3194, 3212, 3573, 3594], 'clones': [2448], 'encoding': [2449, 3065, 3936], 'rat': [2450, 3332], 'described': [2454, 3884, 3910, 3994, 4315], 'Scholar.': [2503], 'clone': [2506], 'encodes': [2508, 3226, 3278, 3506, 3549, 3815], 'murine': [2511], 'gift': [2515, 2624, 2741], '(Department': [2519], 'Molecular': [2521], 'Cellular': [2523, 4004], 'Biology,': [2524], 'Harvard': [2525], 'University)': [2526], '(31Cheng': [2527], 'bait': [2544, 2988, 3026, 3040, 3255, 3374, 3466, 3497, 3654, 3716, 3812, 3842, 3927], 'vector': [2545, 2549, 3048, 3128, 3395, 4044], 'pBTM116': [2546, 3014], 'prey': [2548, 2593, 3470, 3544, 3638, 3662, 3772, 3803, 3835, 3929], 'pVP16': [2550], 'provided': [2552, 2595, 2978], 'Hollenberg': [2555, 2565, 3480, 3888], '(Fred': [2556], 'Hutchinson': [2557], 'Cancer': [2558], 'Research': [2559], 'Center,': [2560], 'Seattle,': [2561], 'WA)': [2562], '(40Vojtek': [2563, 3478, 3886], 'A.B.': [2564, 3479, 3887], 'Cooper': [2567, 3482, 3890], '74:': [2571, 3486, 3894], '205-214Abstract': [2572, 3487, 3895], '(1663)': [2578, 3493, 3901], 'mouse': [2582, 2676, 2766], 'library': [2584, 3505, 3531, 3548, 3578, 3692, 3701], 'pVP16,': [2586, 3472], 'PER': [2588, 2592, 3841], 'bait,': [2589, 3258, 3260, 3783], 'Weitz': [2598, 3540], 'Gekakis': [2601, 3537], '(Harvard': [2602, 2746, 3541], 'Medical': [2603, 2747], 'School).': [2604], 'Polyclonal': [2605], 'antibody': [2606, 2678, 2723, 2768, 4428], '1310,': [2607], 'raised': [2608], 'against': [2609, 2726], 'immunizing': [2620], 'peptide': [2621], 'Burgess': [2627], '(Amgen,': [2628], 'Inc.)': [2629, 2819, 2917], '(immunizing': [2630, 2671], 'peptide,': [2631, 2672], 'CNSFLRHARETPDSYRDS)': [2632], 'Antibody': [2659, 2690], 'sc-537,': [2660], 'recognizing': [2662], 'FLRHARETPDSYRDSPHSER)': [2673], 'anti-Myc': [2675], 'monoclonal': [2677, 2722, 2767], '9e10': [2679, 4507], 'purchased': [2681, 2731, 2771, 2789], 'Santa': [2683], 'Cruz': [2684], 'Biotechnology,': [2685], 'Inc.': [2686, 2775, 2794], '(Santa': [2687], 'Cruz,': [2688], 'CA).': [2689, 2735], 'sc-537': [2691, 2711], 'immunohistochemical': [2696], 'experiments': [2697, 2703, 2787], 'because': [2698, 3672, 3679], 'time': [2701], 'conducted,': [2705], 'little': [2706], 'Ab': [2707, 4506, 4512], '1310': [2708, 2713, 4513], 'remained.': [2709], 'Antibodies': [2710], 'given': [2715], 'similar': [2716], 'results': [2717], 'experiments.': [2720], 'Mouse': [2721], '7D5,': [2724], 'directed': [2725], 'ectodomain,': [2729], 'NeoMarkers': [2733], '(Fremont,': [2734], 'Anti-SV2': [2736], 'hybridoma': [2737], 'supernatant': [2738, 4221], 'Dr.': [2743], 'Kathy': [2744], 'Buckley': [2745], 'School)': [2748], '(41Buckley': [2749], 'Kelly': [2751], '100:': [2757], '1284-1294Crossref': [2758], '(576)': [2761], 'anti-FLAG': [2765], 'M2': [2769], 'International': [2773], 'Biotechnologies,': [2774], '(New': [2776], 'Haven,': [2777], 'CT).': [2778], 'secondary': [2780, 3765], 'antibodies': [2781, 4553], 'Western': [2783, 3416, 3447, 4408], 'blot': [2784, 3417, 4409], 'immunofluorescence': [2786], 'Jackson': [2791], 'ImmunoResearch': [2792], 'Laboratories,': [2793], '(West': [2795], 'Grove,': [2796], 'PA).': [2797], 'Culture': [2798], 'conditions': [2799], 'COS-7': [2801, 2846, 3429, 4310], 'follows:': [2805], '37': [2806, 4079], '°C;': [2807], '8%': [2808], 'CO2;': [2809], 'consisting': [2811, 3553], "Dulbecco's": [2813, 2900, 2946], 'modified': [2814, 2901, 2947, 3210], "Eagle's": [2815, 2902, 2948], '(Life': [2817, 2915], 'Technologies,': [2818, 2916], 'supplemented': [2820], '10%': [2822, 2905, 2942, 4173, 4420, 4464], 'fetal': [2823], 'bovine': [2824], 'serum,': [2825], '2': [2826, 3694], 'mml-glutamine,': [2827], '100': [2828, 2832, 2892, 4153, 4167, 4247], 'units/ml': [2829], 'penicillin,': [2830], 'μg/ml': [2833, 4154, 4505, 4511, 4518], 'streptomycin.': [2834], 'Plasmid': [2835, 2843], 'DNA': [2836, 2869, 2926, 3033, 3512], 'transfections': [2838], 'purified': [2840, 3010], 'using': [2841, 2850, 3015, 3073, 3201, 3360, 4024, 4456], 'Qiagen': [2842], 'Maxi': [2844], 'kits.': [2845], 'transfected': [2849, 3431, 4313], 'DEAE-dextran.': [2851], 'Briefly,': [2852], '5': [2853, 4147, 4284, 4405, 4437, 4523], '×': [2854, 3695, 4033, 4039, 4119, 4212, 4269, 4347], '105': [2855], 'plated': [2858], '100-mm': [2861, 4336], 'dish': [2862], '24': [2863], 'h': [2864, 2933, 4257, 4326, 4491], 'transfection.': [2867], 'transfection': [2870, 2927, 4328], 'solution': [2871, 2928], 'prepared': [2873, 3060, 3140, 3534, 3580], 'adding': [2875], '10': [2876, 4135, 4184, 4290], 'μg': [2877], 'plasmid': [2879, 2974, 3256, 3467, 3471, 3545, 3773, 3804, 3813], 'DNA,': [2880], '30': [2881], 'μl': [2882, 2890, 4248, 4331, 4391, 4412], '50': [2884, 4071, 4390], 'mg/ml': [2885], 'DEAE-dextran': [2886], '(Sigma),': [2887], '6': [2889, 2897, 3456], 'mm': [2893, 4133, 4140, 4285, 4288, 4462, 4483, 4539], 'chloroquine': [2894], '(Sigma)': [2895], 'ml': [2898, 3974, 4072, 4128, 4148, 4171, 4185, 4524], 'containing': [2904, 3810, 4152], 'Nu-Serum': [2906], '(Collaborative': [2907], 'Biomedical': [2908], 'Products).': [2909], 'Cells': [2910, 2937, 4322], 'rinsed': [2912], 'PBS': [2914, 4275], 'or': [2918, 3261, 3312, 3678, 4516, 4566], 'without': [2920, 4301], 'serum': [2921], 'then': [2923, 2939, 3214, 4090, 4112, 4244, 4387, 4449], 'incubated': [2924, 4077, 4105, 4157, 4245, 4362, 4498], '(6': [2929, 2950], 'ml/dish)': [2930, 2951], '4': [2932, 4109, 4218, 4259, 4353, 4365, 4501], 'incubator.': [2936, 2971], 'shocked': [2940], 'Me2SO': [2943], 'serum-free': [2945], '3': [2953, 3973], 'min.': [2954, 4087, 4162, 4406], 'Me2SO-containing': [2956], 'replaced': [2959], 'normal': [2961], 'medium,': [2963], 'dishes': [2966], 'returned': [2968], 'Details': [2972], 'construct': [2975, 3225, 3277, 3498], 'structure': [2976], 'legend': [2981, 3913], '2.': [2984], 'make': [2986, 3327], 'constructs,': [2989, 3370], 'target': [2991], 'sequences': [2992, 3249, 3604], '(NRG': [2993], 'tails)': [2997], 'amplified': [2999], '(PCR).': [3004], 'PCR': [3006], 'products': [3007], 'gel': [3009], 'subcloned': [3012, 3357], 'EcoRI': [3017, 3382], 'andBamHI': [3018], 'sites.': [3019, 3078, 3364], 'illustrated': [3021, 3219, 3271], '2,': [3024, 3222, 3274], 'fusions': [3029], 'LexA': [3032, 3511], '(N-terminally': [3036], 'fused)': [3037], '(C-terminally': [3042], 'fused).': [3043], 'Myc/pcDNA3.1,': [3044], 'designed': [3049, 3129], 'express': [3051], 'recombinant': [3052, 3134], 'N-terminal': [3056, 3237, 3294], 'Myc': [3057], 'tag,': [3058], 'ligating': [3062], 'Myc-tag': [3064], 'cassette': [3066, 3080, 3138, 3169], 'pcDNA3.1(+)': [3068, 3359], '(Invitrogen,': [3069], 'San': [3070], 'Diego,': [3071], 'CA)': [3072], 'BstXI': [3075], 'NotI': [3077, 3187, 3362], 'made': [3082], 'annealing': [3084, 3142], 'oligos,': [3087], '5′-CTGGATC': [3088], 'ATG': [3089, 3146, 3200], 'GGG': [3090], 'GAA': [3091, 3097], 'CAG': [3092, 3104], 'AAA': [3093], 'CTC': [3094, 3106], 'ATC': [3095, 3105, 3160], 'TCT': [3096], 'GAG': [3098, 3110], 'GAT': [3099, 3109, 3152], 'CTG': [3100, 3112], 'GC-3′': [3101], '5′-GGCCGC': [3103], 'TTC': [3107, 3113], 'AGA': [3108], 'TTT': [3111], 'CCC': [3114], 'CAT': [3115, 3166], 'GATCCAGCACA-3′.': [3116], 'same': [3118], 'strategy': [3119, 3204], 'generate': [3123, 3366], 'flag/pcDNA3.1,': [3124], 'produce': [3131, 3743], 'N-terminally': [3132], 'FLAG-tagged': [3133, 3244, 3302], 'FLAG-encoding': [3137], 'oligos': [3144], '5′-GATCCATC': [3145], 'GAC': [3147, 3150, 3151, 3153], 'TAC': [3148], 'AAG': [3149, 3154], 'G-3′': [3155], '5′-AATTC': [3157], 'CTT': [3158, 3163], 'GTC': [3159, 3161, 3162, 3165], 'GTA': [3164], 'GATG-3′.': [3167], 'ligated': [3171, 3215, 3265, 3391], 'theEcoRI': [3173], 'BamHI': [3175], 'sites': [3176], 'pcDNA3.1(+).': [3178], 'create': [3180, 3243], 'Myc-tagged': [3182, 4423], 'construct,': [3185], 'site': [3188], 'introduced': [3190], 'immediately': [3195, 4439], 'upstream': [3196], 'initiator': [3199], 'multi-step': [3203], '(details': [3205], 'available': [3206], 'upon': [3207], 'request).': [3208], 'Myc/pcDNA3.1.': [3217], 'resulting': [3224, 3276, 3639], 'fusion': [3228, 3280, 3368, 3508, 3551, 4048, 4369], 'Myc-epitope': [3232], 'tag': [3233, 3290], 'appended': [3234, 3291], 'onto': [3235, 3292, 3874], 'end': [3238, 3295], 'tails,': [3247], 'insert': [3248, 3935], 'appropriate': [3252], '(NRGc': [3257, 3499], 'NRGb': [3259], 'NRGa': [3262], 'bait)': [3263, 3500], 'flag/pcDNA3.1': [3268], 'vector.': [3269], '(flag-NRGc-tail,': [3282], 'flag-NRGb-tail,': [3283], 'flag-NRGa-tail)': [3285], 'FLAG': [3288], 'epitope': [3289], 'form.': [3300], 'do': [3307], 'therefore': [3319], 'expected': [3320, 3424], 'soluble': [3323], 'vectors': [3329], 'NRGs,': [3333], 'cDNAs': [3335], 'R22': [3336], '(NDF': [3337, 3344, 3351], 'β2a;': [3338], 'GenBank': [3339], 'accession': [3340, 3346, 3353], 'U02318),': [3342], 'R19': [3343], 'α2b;': [3345], 'U02316),': [3348], 'R44': [3350], 'α2c;': [3352], 'U02324)': [3355], 'andEcoRV': [3363], 'GST': [3367, 4042, 4047, 4368], 'constructs': [3375, 3401, 4050], 'NRGas-bait': [3376], 'NRGc-bait': [3378], 'digested': [3380], 'SalI,': [3384], 'tail-encoding': [3388], 'fragment': [3389], 'in-frame': [3392], 'pGEX-4T-1': [3396, 4045], '(Amersham': [3397, 4252], 'Pharmacia': [3398, 4253], 'Biotech).': [3399], 'verified': [3403], 'restriction': [3405], 'digestion': [3406], 'automated': [3409], 'dye': [3410], 'terminator': [3411], 'cycle': [3412], 'sequencing': [3413], '(Applied': [3414], 'Biosystems).': [3415], 'analysis': [3418], 'confirmed': [3419], 'size': [3425, 3642], 'constructs.': [3438], 'Expressed': [3439], 'sometimes': [3441], 'appeared': [3442], 'doublet': [3445], 'blots,': [3448], 'presumably': [3449], 'heterogeneous': [3452], 'glycosylation': [3453], '(cf.': [3454], 'A).': [3457], 'screening': [3461, 3503], 'here': [3463], 'employed': [3464], 'pBTM116,': [3468], 'strain': [3476, 4059], 'L40': [3477, 3706, 3808], 'portion': [3517, 3632], 'NRGs.': [3527], 'screened': [3532], 'University).': [3542], 'Each': [3543], 'of:': [3554], '1)': [3555, 3767], 'nuclear': [3557], 'localization': [3558], 'sequence,': [3559], '2)': [3560, 3785], 'VP16': [3562], 'transactivation': [3563], 'domain,': [3564], '3)': [3566], '2).': [3576], 'mRNA': [3582], 'obtained': [3583], '3-week-old': [3589], 'mouse.': [3590], 'strand': [3593], 'random': [3597], 'primed': [3598], 'minimize': [3600], 'bias': [3601], 'toward': [3602], 'C-terminal': [3603], 'size-selected': [3607], 'length': [3610, 3616], '300–800': [3612], 'base': [3613], 'pairs.': [3614], 'sufficient': [3618], 'encompass': [3620], 'individual': [3621], 'domains': [3623], 'but,': [3624], 'cases,': [3627], 'encode': [3629], 'protein.': [3635], 'partial-length': [3637], 'selection': [3643], 'advantageous': [3646], 'allowing': [3648], 'identification': [3649], 'interactions': [3651], 'would': [3664], 'assay,': [3670, 3850, 3967, 4309], 'either': [3671], 'membrane-associated': [3677], 'contains': [3681], 'regulatory': [3683], 'blocks': [3686], 'bait.': [3690, 3796], 'had': [3693, 3709, 3933], '106': [3696], 'primary': [3697, 3747, 3758, 4552], 'recombinants.': [3698], 'For': [3699, 3797, 3846, 3963, 4304, 4407, 4579], 'screening,': [3700], 'plasmids': [3702, 3751], 'transformed': [3704, 3712, 3806, 3853, 3925, 4055], 'previously': [3710], 'NRGc': [3715, 3782, 3795], 'plasmid.': [3717], 'version': [3719], 'employs': [3726], 'independent': [3728], 'reporter': [3729], 'genes,': [3730], 'HIS3': [3731], 'LacZ.': [3733], 'Colonies': [3734], 'grow': [3736], 'histidine': [3740], 'β-galactosidase': [3744, 3848, 3879, 3966], 'positives.': [3749], 'Prey': [3750], 'isolated': [3752, 3774], 'colonies': [3754, 3851], 'positive': [3755, 3778, 3918], 'further': [3761, 3844, 4302], 'tested': [3762], 'screen:': [3766], 'confirm': [3769], 'initial': [3777], 'test': [3787], 'specificity': [3789, 3799], 'control,': [3800], 'candidate': [3802], 'PAS': [3817, 3938], 'Drosophila': [3821], 'periodic': [3822], 'PER.': [3824], 'similarity': [3831], 'Only': [3834], 'showing': [3836], 'evaluated.': [3845], 'filter': [3849], 'picked': [3856], 'patched': [3858], 'triplicate': [3860], 'tryptophan,': [3864, 3978], 'leucine,': [3865, 3979], 'uracil,': [3866, 3980], 'lysine.': [3868], 'patches': [3871], 'transferred': [3873, 4223, 4450], 'nitrocellulose': [3875], 'filters,': [3876], 'assay': [3880, 3922, 3990], 'elsewhere': [3885, 3995], 'Strength': [3904], 'scored': [3908], '3.': [3916], 'control': [3919], 'plasmids,': [3930], 'PER,': [3941], 'self-associate': [3947], '(42Huang': [3948], 'Z.J.': [3949], 'Edery': [3950], 'Rosbash': [3952], '364:': [3956], '259-262Crossref': [3957], '(417)': [3960], 'liquid': [3965], 'transformants': [3969], 'inoculated': [3971], 'lysine': [3982], 'grown': [3984], 'until': [3985], 'A600': [3986], '=': [3987, 4028], '1.0.': [3988], '(43Bartel': [3996], 'Chien': [3998], 'C.-T.': [3999], 'Sternglanz': [4000], 'Fields': [4002], 'Interactions': [4005], 'Development:': [4007], 'A': [4008], 'Practical': [4009], 'Approach.in:': [4010], 'Hartley': [4011], 'Oxford': [4013], 'University': [4014], 'Press,': [4015], 'New': [4016], 'York1993Google': [4017], 'β-Galactosidase': [4019], 'unit': [4020], 'activity': [4021, 4027], 'calculated': [4023], 'formula:': [4026], '1000': [4029], '×A420/[(time': [4030], 'min)': [4032], '(volume': [4034], 'culture': [4036, 4063, 4094, 4103], 'ml)': [4038, 4242], 'A600].': [4040], 'GST-NRGas-tail': [4051], 'GST-NRGc-tail': [4053], 'bacterial': [4058], 'BL21.': [4060], 'An': [4061], 'overnight': [4062, 4363, 4499], '2×YT': [4065, 4075], 'diluted': [4068], '1:50': [4069], 'fresh': [4074, 4225], '°C': [4080, 4366, 4403, 4435, 4502], 'shaking': [4083], 'incubator': [4084], '90': [4086], 'Isopropyl-1-thio-β-d-galactopyranoside': [4088], 'added': [4091, 4231], 'final': [4097, 4234], 'concentration': [4098, 4235], '0.1': [4100], 'mm,': [4101], 'additional': [4108], 'h,': [4110], 'bacteria': [4114, 4143, 4190], 'pelleted': [4116], '2500': [4118], 'g.': [4120], 'pellet': [4122], 'washed': [4124, 4271, 4380, 4532], 'once': [4125], '7': [4127], 'STE': [4130, 4151], 'buffer': [4131, 4280, 4334, 4385, 4396, 4460, 4481, 4537], '(150': [4132], 'NaCl,': [4134, 4289, 4486, 4542], 'mmTris-HCl,': [4136, 4291], 'pH': [4137, 4292, 4467, 4487, 4546], '8.0,': [4138], 'EDTA).': [4141], 'resuspended': [4145, 4388], 'cold': [4150, 4187], 'lysozyme': [4155], 'ice': [4159], 'Five': [4163], 'hundred': [4164], 'microliters': [4165], 'mmdithiothreitol': [4168], 'sarkosyl': [4174], 'w/v': [4175], 'added,': [4177], 'volume': [4180], 'brought': [4182], 'STE.': [4188], 'lysed': [4192, 4324], 'freezing': [4194], 'thawing': [4196], 'five': [4197], 'times': [4198, 4273, 4382, 4534], 'dry': [4201, 4477], 'ice-ethanol': [4202], 'bath.': [4203], 'lysate': [4205, 4240, 4340, 4360], 'cleared': [4207, 4342], 'centrifugation': [4209, 4266, 4344], '16,000': [4211], 'g': [4213, 4348], '20': [4215], 'min': [4216, 4351, 4438], '°C.': [4219, 4260, 4354], 'tubes,': [4226], 'Triton': [4228, 4282], 'X-100': [4229], '2%': [4237], 'v/v.': [4238], '(≈10': [4241], 'glutathione-agarose': [4250, 4373], 'beads': [4251, 4262, 4374, 4378], 'Biotech)': [4254], 'settled': [4264], '700': [4268, 4346], 'g,': [4270], 'four': [4272, 4533], 'twice': [4277], 'TENT': [4279, 4333, 4384], '(1%': [4281], 'X-100,': [4283], 'EDTA,': [4286], '150': [4287], '7.5),': [4293], 'assays': [4300], 'treatment.': [4303], 'above': [4316], 'Myc-LIMK1': [4319], 'construct.': [4321], '60': [4325], 'after': [4327], '400': [4330], 'per': [4335], 'dish.': [4337], 'One': [4355], 'milliliter': [4356], 'immobilized': [4371], '(20': [4375], 'μl).': [4376], '2×': [4393], 'SDS': [4394], 'sample': [4395, 4415], 'dithiothreitol': [4398], 'heated': [4400, 4432], '95': [4402, 4434], 'analysis,': [4410], 'loaded': [4417], 'SDS-polyacrylamide': [4421, 4444], 'gel.': [4422], 'detected': [4426], '9e10.': [4429], 'Samples': [4430], 'loading': [4442], 'minigels.': [4445], 'Resolved': [4446], 'membranes': [4454, 4471, 4496, 4530], '(Millipore)': [4455], 'CAPS': [4458], 'transfer': [4459], '(10': [4461], 'CAPS,': [4463], 'methyl': [4465], 'alcohol,': [4466], '11)': [4468], '(44).': [4469], 'blocked': [4473], '5%': [4475], 'nonfat': [4476], 'milk': [4478], 'TBS': [4480], '(100': [4482, 4538], 'Tris,': [4484, 4540], '0.9%': [4485, 4541], '7.5)': [4488, 4547], 'room': [4493, 4549], 'temperature.': [4494, 4550], '0.5': [4504, 4517], '(for': [4508, 4514, 4520], 'LIMK1),': [4509], '0.3': [4510], 'NRGs),': [4515], '7D5': [4519], 'NRGs)': [4521], 'blocking': [4527], 'solution.': [4528], 'TTBS': [4536], '0.1%': [4543], 'Tween': [4544], '20,': [4545], 'Bound': [4551], 'visualized': [4555], 'horseradish': [4558], 'peroxidase-conjugated': [4559], 'goat': [4560, 4567], 'anti-mouse': [4561], 'IgG': [4562, 4569], '(1:50,000': [4563, 4570], 'TTBS)': [4565, 4572], 'anti-rabbit': [4568], 'SuperSignal': [4574], 'chemiluminescent': [4575], 'substrate': [4576], '(Pierce).': [4578], 'stripping': [4580], 'reprobing,': [4582], 'blots': [4583]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051127447', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 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