Title: Effect of ondansetron on moderate obstructive sleep apnoea, a single night, placebo‐controlled trial
Abstract: Journal of Sleep ResearchVolume 12, Issue 2 p. 169-170 Effect of ondansetron on moderate obstructive sleep apnoea, a single night, placebo-controlled trial John Stradling, John Stradling Oxford Centre for Respiratory Medicine, Oxford University, Churchill Hospital, Oxford, UK andSearch for more papers by this authorDebbie Smith, Debbie Smith Oxford Centre for Respiratory Medicine, Oxford University, Churchill Hospital, Oxford, UK andSearch for more papers by this authorMiodrag Radulovacki, Miodrag Radulovacki Departments of Pharmacology and Medicine, University of Illinois, Chicago, IL, USASearch for more papers by this authorDavid Carley, David Carley Departments of Pharmacology and Medicine, University of Illinois, Chicago, IL, USASearch for more papers by this author John Stradling, John Stradling Oxford Centre for Respiratory Medicine, Oxford University, Churchill Hospital, Oxford, UK andSearch for more papers by this authorDebbie Smith, Debbie Smith Oxford Centre for Respiratory Medicine, Oxford University, Churchill Hospital, Oxford, UK andSearch for more papers by this authorMiodrag Radulovacki, Miodrag Radulovacki Departments of Pharmacology and Medicine, University of Illinois, Chicago, IL, USASearch for more papers by this authorDavid Carley, David Carley Departments of Pharmacology and Medicine, University of Illinois, Chicago, IL, USASearch for more papers by this author First published: 12 May 2003 https://doi.org/10.1046/j.1365-2869.2003.00342.xCitations: 31 : John Stradling, Oxford Centre for Respiratory Medicine, Oxford University, Churchill Hospital, Oxford, OX3 7LJ, UK. Tel.: 44 1865225236; fax: 44 1865225221; e-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References Anonymous. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep, 1999, 22: 667–689. Carley, D. W. and Radulovacki, M. Role of peripheral serotonin in the regulation of central sleep apneas in rats. Chest, 1999, 115: 1397–1401. Faris, P. L., Kim, S. W., Meller, W. H., Goodale, R. L., Oakman, S. A., Hofbauer, R. D., Marshall, A. M., Daughters, R. S., Banerjee-Stevens, D., Eckert, E. D. and Hartman, B. K. Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomised, double-blind trial. Lancet, 2000, 355: 792–797. Horner, R. L. Is there a rationale in modulating brainstem neurons in obstructive sleep apnea and is it clinically relevant? Sleep, 2000, 23 (Suppl. 4): S179–S181. Jelev, A., Sood, S., Liu, H., Nolan, P. and Horner, R. L. Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J. Physiol., 2001, 532: 467–481. Radulovacki, M., Trbovic, S. M. and Carley, D. W. Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats. Sleep, 1998, 21: 131–136. Sutton, P. M. The interaction between reflex apnoea and bradycardia produced by injecting 5-HT into the nodose ganglion of the cat. Pflugers Arch., 1981, 389: 181–187. Vardhan, A., Kachroo, A. and Sapru, H. N. Excitatory amino acid receptors in the nucleus tractus solitarius mediate the responses to the stimulation of cardio-pulmonary vagal afferent C fiber endings. Brain Res., 1993, 618: 23–31. Veasey, S. C., Chachkes, J., Fenik, P. and Hendricks, J. C. The effects of ondansetron on sleep-disordered breathing in the English bulldog. Sleep, 2001, 24: 155–160. Yoshioka, M., Goda, Y., Togashi, H., Matsumoto, M. and Saito, H. Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. J. Pharmacol. Exp. Ther., 1992, 260: 917–924. Citing Literature Volume12, Issue2June 2003Pages 169-170 ReferencesRelatedInformation